TDMS Study 05169-01 Pathology Tables
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
Facility: Hazleton Laboratories America, Inc.
Chemical CAS #: 2429-74-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 7|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Liver | + + + + +|
Angiectasis, Focal | |
Angiectasis, Multifocal | |
Basophilic Focus | 1 2 1 2|
Clear Cell Focus | 1 |
Eosinophilic Focus | |
Granuloma | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Multifocal| 1 |
Centrilobular, Necrosis, Diffuse | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + +|
Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach | + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + +|
Acanthosis | |
Inflammation, Chronic | |
Ulcer, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + +|
Erosion, Focal | |
Erosion, Multifocal | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
Cardiomyopathy, Chronic | 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 7|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + +|
Angiectasis | 2 3|
Hyperplasia, Focal | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 3|
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | X |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + +|
Ectasia | 3 4|
Hyperplasia, Focal | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + +|
Hydrometra | |
Cervix, Cyst | |
Cervix, Fibrosis | |
Endometrium, Cyst | X |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + +|
Mediastinal, Erythrophagocytosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 7|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | |
Hyperplasia, Re Cell | 3 3 3|
__________________________________________________________________________|
Spleen | + + + + +|
Atrophy | 3|
Hematopoietic Cell Proliferation | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + +|
Ectasia | |
Galactocele | |
Hyperplasia, Multifocal | |
Duct, Ectasia | 3 3 |
__________________________________________________________________________|
Skin | + + + + +|
Hyperkeratosis, Focal | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | +|
Sternum, Osteopetrosis | 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + +|
Congestion | |
Foreign Body | |
Hyperplasia, Lymphoid | 2 2 2|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + +|
Foreign Body | |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Zymbal's Gland | + + + + +|
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 7|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 3 2 2 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + +|
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 6| 6|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 3 |
Angiectasis, Multifocal | |
Basophilic Focus | 1 1 2 1 2 1 2 2 2 2 2 3 1 1 3 2|
Clear Cell Focus | 1 1 1 |
Eosinophilic Focus | 2 |
Granuloma | 2 2 2 3 1 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | 1 |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Multifocal| 3 |
Centrilobular, Necrosis, Diffuse | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic | 3 |
Ulcer, Focal | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Erosion, Multifocal | 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 1 2 2 2 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 6| 6|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal | 2 2 |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | X X |
Pars Distalis, Cyst, Multiple | X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 |
Hyperplasia, Focal | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3|
Cervix, Cyst | |
Cervix, Fibrosis | 2 3 |
Endometrium, Cyst | X |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Erythrophagocytosis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 6| 6|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | |
Hyperplasia, Re Cell | 3 2 3 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 2 |
Pigmentation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Galactocele | X X |
Hyperplasia, Multifocal | |
Duct, Ectasia | 2 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
Sternum, Osteopetrosis | 2 2 3 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 4|
Hyperplasia, Lymphoid | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | 4|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4|
Inflammation, Acute | 2 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 6| 6|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 1 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 3 2 2 2 2 4 2|
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 8| 8| 8| 8| 0| 8| 6| 5| 2| 0| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 2| 3| 4| 9| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 50 |
Hyperkeratosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 50 |
Angiectasis, Focal | 2 | 3 2.3|
Angiectasis, Multifocal | 3 | 1 3.0|
Basophilic Focus | 2 1 2 1 1 2 1 1 1 2 1 1 1 1 | 34 1.5|
Clear Cell Focus | 1 1 1 | 7 1.0|
Eosinophilic Focus | 1 | 2 1.5|
Granuloma | 2 2 1 2 2 | 11 1.9|
Hematopoietic Cell Proliferation | 1 3 2 2 | 5 1.8|
Hepatodiaphragmatic Nodule | X X X X X X X | 10 |
Mixed Cell Focus | | 1 1.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 2 3.0|
Vacuolization Cytoplasmic, Multifocal| | 2 2.0|
Centrilobular, Necrosis, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Necrosis | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 50 |
Acanthosis | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Ulcer, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 50 |
Erosion, Focal | 2 | 1 2.0|
Erosion, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 8| 8| 8| 8| 0| 8| 6| 5| 2| 0| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 2| 3| 4| 9| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 3 2 2 1 2 2 2 | 23 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 50 |
Angiectasis | | 2 2.5|
Hyperplasia, Focal | 2 | 3 2.0|
Vacuolization Cytoplasmic, Diffuse | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 | 2 2.5|
Vacuolization Cytoplasmic, Multifocal| 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 49 |
Hemorrhage | 3 | 1 3.0|
Pars Distalis, Angiectasis, Focal | 2 2 | 2 2.0|
Pars Distalis, Cyst | X X X X X X X | 10 |
Pars Distalis, Cyst, Multiple | | 1 |
Pars Distalis, Hyperplasia, Focal | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 49 |
C-Cell, Hyperplasia, Focal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
Ectasia | 3 3 2 | 10 3.0|
Hyperplasia, Focal | 3 1 2 | 4 2.3|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 50 |
Cyst | X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 50 |
Hydrometra | | 1 3.0|
Cervix, Cyst | X X | 2 |
Cervix, Fibrosis | 3 | 3 2.7|
Endometrium, Cyst | 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 8| 8| 8| 8| 0| 8| 6| 5| 2| 0| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 2| 3| 4| 9| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | + + | 2 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 50 |
Mediastinal, Erythrophagocytosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Re Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 50 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Re Cell | 3 3 3 | 11 2.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 50 |
Atrophy | | 2 3.0|
Hematopoietic Cell Proliferation | 3 4 4 2 | 5 3.0|
Pigmentation | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + M + + + + + + + + + + + + | 47 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M | 49 |
Ectasia | | 1 3.0|
Galactocele | | 2 |
Hyperplasia, Multifocal | 2 | 1 2.0|
Duct, Ectasia | 3 3 3 2 2 | 15 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 49 |
Hyperkeratosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 13 |
Sternum, Osteopetrosis | 3 3 4 3 3 3 3 | 13 2.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 50 |
Compression | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 50 |
Congestion | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 8| 8| 8| 8| 0| 8| 6| 5| 2| 0| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 2| 3| 4| 9| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | | 1 4.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 42 2.0|
Infiltration Cellular, Histiocyte | 1 2 1 2 2 | 6 1.7|
Inflammation, Chronic | | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 50 |
Foreign Body | | 1 4.0|
Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + M + + | 49 |
Ectasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 50 |
Hydronephrosis | 2 | 1 2.0|
Nephropathy, Chronic | 3 2 2 3 1 2 2 2 4 2 3 2 2 3 2 2 3 | 45 2.2|
Renal Tubule, Pigmentation | 3 4 | 3 3.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 50 |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 7| 7| 8| 8| 5| 0| 0| 8| 8| 8| 4| 6|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 9| 6| 2| 2| 8| 6| 6| 2| 2| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.063 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis, Multifocal | 2 |
Basophilic Focus | 2 1 2 2 2 2 1 2 1 1 |
Clear Cell Focus | 1 2 |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | 1 3 |
Granuloma | 2 2 2 |
Hematopoietic Cell Proliferation | 1 2 1 2 |
Hepatodiaphragmatic Nodule | X |
Vacuolization Cytoplasmic, Diffuse | 3|
Vacuolization Cytoplasmic, Multifocal| 2 |
Bile Duct, Hyperplasia | |
Centrilobular, Degeneration, Diffuse | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Pharynx | + + + |
Palate, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Erosion, Diffuse | |
Mineralization, Diffuse | |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 1 1 1 2 2 |
Mineralization, Multifocal | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 7| 7| 8| 8| 5| 0| 0| 8| 8| 8| 4| 6|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 9| 6| 2| 2| 8| 6| 6| 2| 2| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.063 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | X 2 X |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + +|
Ectasia | 3 2 |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | |
Hyperplasia, Multifocal, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Ectasia, Focal | |
Cervix, Fibrosis | |
Endometrium, Cyst | 2 |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
Cyst | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Necrosis, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 7| 7| 8| 8| 5| 0| 0| 8| 8| 8| 4| 6|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 9| 6| 2| 2| 8| 6| 6| 2| 2| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.063 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 3 3 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 3 2 4 3 3 3 |
Hyperplasia, Reticulum Cell | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + M|
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Duct, Ectasia | 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Hair Follicle, Hyperplasia, Basal | |
Cell, Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Sternum, Osteopetrosis | 3 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 2 1 2 2 1 2 2 2 2 |
Infiltration Cellular, Histiocyte | 3 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 7| 7| 8| 8| 5| 0| 0| 8| 8| 8| 4| 6|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 9| 6| 2| 2| 8| 6| 6| 2| 2| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.063 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Retina, Degeneration | 4 3 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Ectasia | 1 1 2 3 |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Infarct, Chronic | |
Nephropathy, Chronic | 3 2 2 2 1 2 1 1 2 2 |
Cortex, Cyst | |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 6| 6| 6| 5| 5| 4| | |
DAY ON TEST | 8| 3| 3| 3| 6| 5| 4| 4| 2| 6| 8| 8| 8| 4| 8| 4| 2| 6| 0| 9| | |
| 2| 5| 5| 5| 5| 3| 7| 7| 9| 3| 2| 3| 3| 0| 3| 7| 2| 5| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.063 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 35 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 35 |
Angiectasis, Focal | 2 | 1 2.0|
Angiectasis, Multifocal | 2 | 2 2.0|
Basophilic Focus | 1 1 2 3 1 2 2 2 | 18 1.7|
Clear Cell Focus | 1 | 3 1.3|
Degeneration, Cystic, Focal | 1 | 1 1.0|
Eosinophilic Focus | | 2 2.0|
Granuloma | 2 4 2 1 | 7 2.1|
Hematopoietic Cell Proliferation | 1 | 5 1.4|
Hepatodiaphragmatic Nodule | | 1 |
Vacuolization Cytoplasmic, Diffuse | 3 3 4 3 | 5 3.2|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
Bile Duct, Hyperplasia | 3 | 1 3.0|
Centrilobular, Degeneration, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Necrosis | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 35 |
Atrophy | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 4 |
Palate, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 35 |
Acanthosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 35 |
Erosion, Diffuse | 3 | 1 3.0|
Mineralization, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 6| 6| 6| 5| 5| 4| | |
DAY ON TEST | 8| 3| 3| 3| 6| 5| 4| 4| 2| 6| 8| 8| 8| 4| 8| 4| 2| 6| 0| 9| | |
| 2| 5| 5| 5| 5| 3| 7| 7| 9| 3| 2| 3| 3| 0| 3| 7| 2| 5| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.063 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 35 |
Cardiomyopathy, Chronic | 1 2 2 2 1 2 2 2 | 14 1.7|
Mineralization, Multifocal | 3 | 1 3.0|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 35 |
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 2 2.5|
Vacuolization Cytoplasmic, Focal | 1 | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 35 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + M + + + + + | 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
Hemorrhage | 4 | 1 4.0|
Pars Distalis, Angiectasis, Focal | 2 2 2 | 4 2.0|
Pars Distalis, Cyst | X 2 X 4 X 3 | 9 2.8|
Pars Distalis, Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
C-Cell, Hyperplasia, Focal | 1 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + M M + + + + + + + + + + | 31 |
Ectasia | 3 3 | 4 2.8|
Hyperplasia, Focal | 2 2 | 2 2.0|
Hyperplasia, Focal, Squamous | 2 | 1 2.0|
Hyperplasia, Multifocal, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 35 |
Cyst | X X X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 35 |
Ectasia, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 6| 6| 6| 5| 5| 4| | |
DAY ON TEST | 8| 3| 3| 3| 6| 5| 4| 4| 2| 6| 8| 8| 8| 4| 8| 4| 2| 6| 0| 9| | |
| 2| 5| 5| 5| 5| 3| 7| 7| 9| 3| 2| 3| 3| 0| 3| 7| 2| 5| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.063 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cervix, Fibrosis | 3 | 1 3.0|
Endometrium, Cyst | X X | 3 2.0|
Endometrium, Hyperplasia, Cystic | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 35 |
Hyperplasia | 3 | 2 3.0|
Necrosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 35 |
Mediastinal, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 33 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Hyperplasia, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | 34 |
Hyperplasia, Re Cell | 3 3 2 | 7 2.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 35 |
Atrophy | 3 3 4 | 3 3.3|
Hematopoietic Cell Proliferation | 2 4 2 3 4 | 12 2.9|
Hyperplasia, Reticulum Cell | 3 | 1 3.0|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + M + + + + + + + + + + + + | 31 |
Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + | 34 |
Duct, Ectasia | 3 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 34 |
Hair Follicle, Hyperplasia, Basal | | |
Cell, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 4 |
Sternum, Osteopetrosis | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 35 |
Compression | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 6| 6| 6| 5| 5| 4| | |
DAY ON TEST | 8| 3| 3| 3| 6| 5| 4| 4| 2| 6| 8| 8| 8| 4| 8| 4| 2| 6| 0| 9| | |
| 2| 5| 5| 5| 5| 3| 7| 7| 9| 3| 2| 3| 3| 0| 3| 7| 2| 5| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.063 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 35 |
Congestion | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 3 2 2 2 2 2 2 2 2 2 2 | 22 2.0|
Infiltration Cellular, Histiocyte | 2 | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 35 |
Fungus | X 2 | 2 2.0|
Inflammation, Acute | 3 2 | 2 2.5|
Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 1 | 2 1.5|
Retina, Degeneration | 3 | 3 3.3|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
Ectasia | 3 | 5 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia, Focal, Squamous | | 2 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 35 |
Infarct, Chronic | 3 | 1 3.0|
Nephropathy, Chronic | 1 3 2 3 1 1 2 2 2 2 3 2 | 22 1.9|
Cortex, Cyst | X | 1 |
Renal Tubule, Mineralization | 3 | 1 3.0|
Renal Tubule, Pigmentation | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 6| 4| 6| 6| 6| 5| 3|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 3| 3| 5| 8| 8| 3| 2| 9| 8| 5| 5| 2| 6|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 0| 2| 3| 0| 9| 2| 2| 0| 6| 5| 2| 9| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Descending Colon, Necrosis, Focal | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | 1 2 2 2 1 3 2|
Clear Cell Focus | |
Eosinophilic Focus | 2 |
Fatty Change | 3 |
Granuloma | 3 |
Hematopoietic Cell Proliferation | 2|
Hepatodiaphragmatic Nodule | |
Necrosis, Coagulative | |
Necrosis, Multifocal | |
Pigmentation | |
Regeneration, Diffuse | 4 |
Regeneration, Focal | |
Regeneration, Multifocal | 2 4 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Cyst | 4 |
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Pharynx | + + + + + |
Palate, Hyperkeratosis, Focal | |
Palate, Hyperplasia, Focal | |
Palate, Hyperplasia, Focal, Squamous | |
Palate, Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 6| 4| 6| 6| 6| 5| 3|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 3| 3| 5| 8| 8| 3| 2| 9| 8| 5| 5| 2| 6|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 0| 2| 3| 0| 9| 2| 2| 0| 6| 5| 2| 9| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acanthosis | |
Inflammation, Chronic | |
Ulcer, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Erosion, Focal | 1 |
Erosion, Multifocal | 4 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 1 2 2 2 |
Atrium, Thrombosis | |
Endocardium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | X 4 X 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 3 |
Hyperplasia, Focal | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 6| 4| 6| 6| 6| 5| 3|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 3| 3| 5| 8| 8| 3| 2| 9| 8| 5| 5| 2| 6|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 0| 2| 3| 0| 9| 2| 2| 0| 6| 5| 2| 9| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Focal, Squamous | |
Hyperplasia, Multifocal, Squamous | |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Cyst | X X 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Ectasia, Focal | |
Hydrometra | |
Prolapse | 4 |
Cervix, Fibrosis | 3 |
Endometrium, Cyst | X X 1 |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | 3|
Mediastinal, Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 3|
Hyperplasia, Reticulum Cell | 3 3 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + +|
Galactocele | |
Duct, Ectasia | 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 6| 4| 6| 6| 6| 5| 3|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 3| 3| 5| 8| 8| 3| 2| 9| 8| 5| 5| 2| 6|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 0| 2| 3| 0| 9| 2| 2| 0| 6| 5| 2| 9| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + |
Sternum, Osteopetrosis | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 2 3 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Cornea, Inflammation, Chronic Active | 4 |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Ectasia | 2 1 2 4 |
Hyperplasia, Focal, Squamous | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Infarct, Acute | 3 |
Nephropathy, Chronic | 2 2 2 2 2 1 2 3 1 1 1 |
Cortex, Cyst | |
Renal Tubule, Degeneration | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 5| 5| 2| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 4| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 4| 9| 5| 5| 8| 8| 8| 0| 7| 8| 8| 5| 1| 6| 4| 4| 3| 2| 7| 8| 4| 2| 8| 3|
| 2| 6| 2| 5| 3| 0| 2| 2| 8| 2| 2| 2| 9| 6| 0| 6| 5| 3| 4| 9| 2| 0| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Descending Colon, Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 1 |
Basophilic Focus | 1 2 1 3 2 1 3 2 2 1 3 1 |
Clear Cell Focus | 2 |
Eosinophilic Focus | 2 |
Fatty Change | |
Granuloma | 2 2 1|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2|
Hepatodiaphragmatic Nodule | X X X X X X |
Necrosis, Coagulative | 3|
Necrosis, Multifocal | 3 1 2 |
Pigmentation | |
Regeneration, Diffuse | |
Regeneration, Focal | 3 3 |
Regeneration, Multifocal | 3 3 |
Vacuolization Cytoplasmic, Diffuse | 3 4 2 2 |
Vacuolization Cytoplasmic, Focal | 3 |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Cyst | X |
Centrilobular, Degeneration, Diffuse | 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
__________________________________________________________________________|
Pharynx | + + + + + + + |
Palate, Hyperkeratosis, Focal | |
Palate, Hyperplasia, Focal | |
Palate, Hyperplasia, Focal, Squamous | 1 |
Palate, Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 5| 5| 2| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 4| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 4| 9| 5| 5| 8| 8| 8| 0| 7| 8| 8| 5| 1| 6| 4| 4| 3| 2| 7| 8| 4| 2| 8| 3|
| 2| 6| 2| 5| 3| 0| 2| 2| 8| 2| 2| 2| 9| 6| 0| 6| 5| 3| 4| 9| 2| 0| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acanthosis | |
Inflammation, Chronic | |
Ulcer, Focal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Erosion, Multifocal | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 1 2 2 2 1 |
Atrium, Thrombosis | X X |
Endocardium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 2 1 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic, Multifocal| 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis, Focal | 1 2 3 |
Pars Distalis, Cyst | X X 2 X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | |
Ectasia | 3 3 3|
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 5| 5| 2| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 4| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 4| 9| 5| 5| 8| 8| 8| 0| 7| 8| 8| 5| 1| 6| 4| 4| 3| 2| 7| 8| 4| 2| 8| 3|
| 2| 6| 2| 5| 3| 0| 2| 2| 8| 2| 2| 2| 9| 6| 0| 6| 5| 3| 4| 9| 2| 0| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Focal, Squamous | 3 |
Hyperplasia, Multifocal, Squamous | 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Focal | |
Hydrometra | |
Prolapse | |
Cervix, Fibrosis | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
Hypoplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Re Cell | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 3 3 2 3 2 3 4 2 4 3|
Hyperplasia, Reticulum Cell | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Galactocele | X |
Duct, Ectasia | 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 5| 5| 2| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 4| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 4| 9| 5| 5| 8| 8| 8| 0| 7| 8| 8| 5| 1| 6| 4| 4| 3| 2| 7| 8| 4| 2| 8| 3|
| 2| 6| 2| 5| 3| 0| 2| 2| 8| 2| 2| 2| 9| 6| 0| 6| 5| 3| 4| 9| 2| 0| 7| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + +|
Sternum, Osteopetrosis | 3 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | 2 2 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 2 3 |
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 3 |
Cornea, Inflammation, Chronic Active | |
Retina, Degeneration | 4 3 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Ectasia | 1 3 2 |
Hyperplasia, Focal, Squamous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct, Acute | |
Nephropathy, Chronic | 2 2 1 2 1 2 1 1 2 2 1 1 1 1 2 1 2 |
Cortex, Cyst | |
Renal Tubule, Degeneration | 3 |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
DAY ON TEST | 8| 7| 4| 8| 3| 8| 8| 8| 6| 3| 8| 2| 2| 5| 4| 8| 8| 8| 5| 2| 8| 8| 8| 8| 9| |
| 3| 3| 0| 9| 2| 3| 3| 3| 6| 8| 3| 5| 5| 9| 9| 3| 3| 3| 9| 0| 3| 3| 3| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Descending Colon, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Angiectasis, Focal | 1 | 2 1.0|
Basophilic Focus | 2 3 2 4 2 2 3 3 2 2 2 1 2 3 | 33 2.1|
Clear Cell Focus | | 1 2.0|
Eosinophilic Focus | 2 | 3 2.0|
Fatty Change | | 1 3.0|
Granuloma | 2 | 5 2.0|
Hematopoietic Cell Proliferation | 2 2 2 1 2 | 14 1.9|
Hepatodiaphragmatic Nodule | X X X | 9 |
Necrosis, Coagulative | 4 | 2 3.5|
Necrosis, Multifocal | | 3 2.0|
Pigmentation | 2 | 1 2.0|
Regeneration, Diffuse | | 1 4.0|
Regeneration, Focal | | 2 3.0|
Regeneration, Multifocal | 3 3 3 | 7 3.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 6 2.7|
Vacuolization Cytoplasmic, Focal | 3 | 2 3.0|
Vacuolization Cytoplasmic, Multifocal| 2 | 1 2.0|
Bile Duct, Cyst | | 2 4.0|
Centrilobular, Degeneration, Diffuse | 2 2 | 3 2.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Fat, Necrosis | 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Atrophy | 2 1 2 | 6 2.0|
__________________________________________________________________________|____________|
Pharynx | + + + + + + + + +| 21 |
Palate, Hyperkeratosis, Focal | 4 | 1 4.0|
Palate, Hyperplasia, Focal | 3 2| 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
DAY ON TEST | 8| 7| 4| 8| 3| 8| 8| 8| 6| 3| 8| 2| 2| 5| 4| 8| 8| 8| 5| 2| 8| 8| 8| 8| 9| |
| 3| 3| 0| 9| 2| 3| 3| 3| 6| 8| 3| 5| 5| 9| 9| 3| 3| 3| 9| 0| 3| 3| 3| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Palate, Hyperplasia, Focal, Squamous | | 1 1.0|
Palate, Hyperplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Acanthosis | 2 3 3 2| 4 2.5|
Inflammation, Chronic | 3 | 1 3.0|
Ulcer, Focal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Erosion, Focal | | 1 1.0|
Erosion, Multifocal | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + + | 6 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Cardiomyopathy, Chronic | 2 2 1 2 2 2 2 1 2 2 2 2 2 | 29 1.8|
Atrium, Thrombosis | X | 3 |
Endocardium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Congestion | | 1 3.0|
Hyperplasia, Focal | 3 | 2 2.5|
Hyperplasia, Multifocal | | 2 1.5|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +| 62 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Hemorrhage | 3 | 1 3.0|
Pars Distalis, Angiectasis, Focal | 2 3 | 6 2.2|
Pars Distalis, Cyst | X X X X X X | 15 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
DAY ON TEST | 8| 7| 4| 8| 3| 8| 8| 8| 6| 3| 8| 2| 2| 5| 4| 8| 8| 8| 5| 2| 8| 8| 8| 8| 9| |
| 3| 3| 0| 9| 2| 3| 3| 3| 6| 8| 3| 5| 5| 9| 9| 3| 3| 3| 9| 0| 3| 3| 3| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia, Focal | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Atrophy | 3 | 1 3.0|
Ectasia | 3 3 2 3 3 3| 10 2.9|
Hyperplasia, Focal | | 4 2.0|
Hyperplasia, Focal, Squamous | 2 | 2 2.5|
Hyperplasia, Multifocal, Squamous | 2 | 2 2.5|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Cyst | X X | 6 3.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Ectasia, Focal | 2 | 1 2.0|
Hydrometra | 3 | 1 3.0|
Prolapse | | 1 4.0|
Cervix, Fibrosis | 3 | 2 3.0|
Endometrium, Cyst | X X X | 6 1.0|
Endometrium, Hyperplasia, Cystic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Hyperplasia | | 2 2.5|
Hypoplasia | 3 3 | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Re Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Angiectasis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Re Cell | 3 3 3 | 5 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
DAY ON TEST | 8| 7| 4| 8| 3| 8| 8| 8| 6| 3| 8| 2| 2| 5| 4| 8| 8| 8| 5| 2| 8| 8| 8| 8| 9| |
| 3| 3| 0| 9| 2| 3| 3| 3| 6| 8| 3| 5| 5| 9| 9| 3| 3| 3| 9| 0| 3| 3| 3| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 3 3 2 3 3 | 20 2.9|
Hyperplasia, Reticulum Cell | 3 | 3 3.0|
Pigmentation | 3 3 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 63 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 63 |
Galactocele | X | 2 |
Duct, Ectasia | 3 3 3 3 3 3 | 11 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Necrosis, Focal | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 12 |
Sternum, Osteopetrosis | 2 2 4 3 2 | 10 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Compression | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 | 41 2.0|
Infiltration Cellular, Histiocyte | 2 1 2 2 4 | 11 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Fungus | 2 | 2 2.0|
Inflammation, Acute | 2 2 | 4 2.3|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| |
DAY ON TEST | 8| 7| 4| 8| 3| 8| 8| 8| 6| 3| 8| 2| 2| 5| 4| 8| 8| 8| 5| 2| 8| 8| 8| 8| 9| |
| 3| 3| 0| 9| 2| 3| 3| 3| 6| 8| 3| 5| 5| 9| 9| 3| 3| 3| 9| 0| 3| 3| 3| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cornea, Inflammation, Chronic Active | | 1 4.0|
Retina, Degeneration | | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Ectasia | 2 2 3 3 2 2 | 13 2.2|
Hyperplasia, Focal, Squamous | 2 1 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Hydronephrosis | | 1 2.0|
Infarct, Acute | | 1 3.0|
Nephropathy, Chronic | 2 2 2 2 1 1 2 1 3 2 2 3 1 3 2 2 2 2 2 1 | 48 1.7|
Cortex, Cyst | X | 1 |
Renal Tubule, Degeneration | | 1 3.0|
Renal Tubule, Pigmentation | 3 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 0| 5| 5| 5| 7| 1| 9| 5| 5| 5| 5|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 3| 8| 9| 9| 9| 2| 6| 5| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
Inflammation, Acute | |
Necrosis, Focal | |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
Inflammation, Acute | |
Necrosis, Focal | |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
__________________________________________________________________________|
Liver | + + + + + |
Basophilic Focus | 1 1 1 |
Clear Cell Focus | |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | 1 |
Erythrophagocytosis | 3 |
Granuloma | |
Hematopoietic Cell Proliferation | 1 2 2 |
Hepatodiaphragmatic Nodule | X |
Necrosis, Multifocal | |
Regeneration, Focal | 3 |
Regeneration, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Necrosis, Diffuse | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + |
__________________________________________________________________________|
Pharynx | + + |
Palate, Hyperkeratosis, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + |
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
Acanthosis | |
Ulcer, Focal | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 0| 5| 5| 5| 7| 1| 9| 5| 5| 5| 5|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 3| 8| 9| 9| 9| 2| 6| 5| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
Erosion, Multifocal | |
Ulcer, Focal | |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis, Focal | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Tooth | |
Gingiva, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
Cardiomyopathy, Chronic | 1 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + |
Hypertrophy, Focal | |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + |
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
Cyst | |
C-Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + |
Ectasia | 3 |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 0| 5| 5| 5| 7| 1| 9| 5| 5| 5| 5|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 3| 8| 9| 9| 9| 2| 6| 5| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + |
Endometrium, Cyst | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Congestion | 1 |
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hemorrhage | |
Hyperplasia, Re Cell | |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + |
Atrophy | |
Hematopoietic Cell Proliferation | 3 3 2 3 |
Necrosis, Multifocal | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + |
Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + |
Galactocele | |
Hyperplasia, Diffuse | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + |
Epidermis, Hypoplasia, Focal | |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Sternum, Osteopetrosis | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
Compression | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 0| 5| 5| 5| 7| 1| 9| 5| 5| 5| 5|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 3| 8| 9| 9| 9| 2| 6| 5| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + |
Congestion | 3 |
Hyperplasia, Lymphoid | 2 2 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + |
Fungus | |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + |
Ectasia | |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Hydronephrosis | 2 |
Nephropathy, Chronic | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 5| 6| 5| 5| 5| 4| 6| 6| 4| 4| 4|
DAY ON TEST | 8| 4| 1| 0| 6| 2| 0| 7| 2| 0| 8| 4| 2| 8| 8| 4| 8| 6| 1| 0| 4| 3| 7| 6| 0|
| 2| 5| 9| 0| 6| 4| 7| 8| 7| 2| 2| 6| 3| 5| 5| 6| 5| 4| 3| 8| 6| 5| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.25 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Necrosis, Focal | |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 4 1 2 2 2 1 1 3 2 2 |
Clear Cell Focus | |
Degeneration, Cystic, Focal | 3 |
Eosinophilic Focus | 1 1 4 4 |
Erythrophagocytosis | |
Granuloma | 3 |
Hematopoietic Cell Proliferation | 3 2 3 2 2 |
Hepatodiaphragmatic Nodule | X |
Necrosis, Multifocal | 1 |
Regeneration, Focal | |
Regeneration, Multifocal | 3 4 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic, Multifocal| |
Centrilobular, Degeneration, Diffuse | 3 |
Centrilobular, Necrosis, Diffuse | 3 3 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | + + + + + + |
Palate, Hyperkeratosis, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Ulcer, Focal | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 5| 6| 5| 5| 5| 4| 6| 6| 4| 4| 4|
DAY ON TEST | 8| 4| 1| 0| 6| 2| 0| 7| 2| 0| 8| 4| 2| 8| 8| 4| 8| 6| 1| 0| 4| 3| 7| 6| 0|
| 2| 5| 9| 0| 6| 4| 7| 8| 7| 2| 2| 6| 3| 5| 5| 6| 5| 4| 3| 8| 6| 5| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.25 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multifocal | 2 |
Ulcer, Focal | |
__________________________________________________________________________|
Tongue | + + + + |
Hyperkeratosis, Focal | |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Tooth | + |
Gingiva, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 2 |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | X 3 |
Pars Distalis, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 4 3 3 |
Hyperplasia, Focal | 2 3 |
Hyperplasia, Focal, Squamous | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 5| 6| 5| 5| 5| 4| 6| 6| 4| 4| 4|
DAY ON TEST | 8| 4| 1| 0| 6| 2| 0| 7| 2| 0| 8| 4| 2| 8| 8| 4| 8| 6| 1| 0| 4| 3| 7| 6| 0|
| 2| 5| 9| 0| 6| 4| 7| 8| 7| 2| 2| 6| 3| 5| 5| 6| 5| 4| 3| 8| 6| 5| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.25 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Cyst | X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 |
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Re Cell | 3 3 3 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 3 4 3 4 4 3 3 2 4 |
Necrosis, Multifocal | |
Pigmentation | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + M + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Galactocele | X |
Hyperplasia, Diffuse | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hypoplasia, Focal | 3 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Sternum, Osteopetrosis | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 5| 6| 5| 5| 5| 4| 6| 6| 4| 4| 4|
DAY ON TEST | 8| 4| 1| 0| 6| 2| 0| 7| 2| 0| 8| 4| 2| 8| 8| 4| 8| 6| 1| 0| 4| 3| 7| 6| 0|
| 2| 5| 9| 0| 6| 4| 7| 8| 7| 2| 2| 6| 3| 5| 5| 6| 5| 4| 3| 8| 6| 5| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.25 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 2 3 3 |
Hyperplasia, Focal | 2 |
Hyperplasia, Focal, Squamous | 1 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 2 3 1 1 2 2 2 2 2 2 1 2 3 2 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Pigmentation | 3 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 5| 5| 3| 2| 6| 6| 6| 4| 3| 6| 5| 5| 4| 4| | |
DAY ON TEST | 8| 8| 8| 1| 0| 0| 9| 3| 3| 9| 4| 2| 1| 9| 5| 2| 9| 4| 8| 8| | |
| 2| 2| 1| 3| 2| 0| 2| 4| 9| 6| 6| 0| 3| 5| 9| 4| 2| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 50 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Necrosis, Focal | 3 | 1 3.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Acute | | 1 1.0|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 50 |
Basophilic Focus | 2 4 2 4 1 3 2 2 2 | 23 2.0|
Clear Cell Focus | 2 | 1 2.0|
Degeneration, Cystic, Focal | | 1 3.0|
Eosinophilic Focus | 3 | 6 2.3|
Erythrophagocytosis | | 1 3.0|
Granuloma | 3 | 2 3.0|
Hematopoietic Cell Proliferation | 2 3 3 2 1 | 13 2.2|
Hepatodiaphragmatic Nodule | | 2 |
Necrosis, Multifocal | 3 | 2 2.0|
Regeneration, Focal | 3 4 | 3 3.3|
Regeneration, Multifocal | 4 3 | 4 3.5|
Vacuolization Cytoplasmic, Diffuse | 3 4 3 3 2 | 6 2.8|
Vacuolization Cytoplasmic, Focal | 4 | 2 3.0|
Vacuolization Cytoplasmic, Multifocal| 2 | 1 2.0|
Centrilobular, Degeneration, Diffuse | 2 1 | 3 2.0|
Centrilobular, Necrosis, Diffuse | | 2 3.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Pharynx | + + + + M | 12 |
Palate, Hyperkeratosis, Focal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 5| 5| 3| 2| 6| 6| 6| 4| 3| 6| 5| 5| 4| 4| | |
DAY ON TEST | 8| 8| 8| 1| 0| 0| 9| 3| 3| 9| 4| 2| 1| 9| 5| 2| 9| 4| 8| 8| | |
| 2| 2| 1| 3| 2| 0| 2| 4| 9| 6| 6| 0| 3| 5| 9| 4| 2| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 50 |
Acanthosis | 3 | 3 2.3|
Ulcer, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 50 |
Erosion, Multifocal | | 1 2.0|
Ulcer, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + + + | 9 |
Hyperkeratosis, Focal | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 2 1 2 | 20 1.9|
Atrium, Thrombosis | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 50 |
Hypertrophy, Focal | | 1 2.0|
Necrosis, Multifocal | 3 | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 49 |
Pars Distalis, Angiectasis, Focal | 3 2 2 | 4 2.3|
Pars Distalis, Cyst | 2 2 3 | 6 2.6|
Pars Distalis, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
Cyst | 2 | 1 2.0|
C-Cell, Hyperplasia, Focal | 1 1 | 2 1.0|
Follicular Cell, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 5| 5| 3| 2| 6| 6| 6| 4| 3| 6| 5| 5| 4| 4| | |
DAY ON TEST | 8| 8| 8| 1| 0| 0| 9| 3| 3| 9| 4| 2| 1| 9| 5| 2| 9| 4| 8| 8| | |
| 2| 2| 1| 3| 2| 0| 2| 4| 9| 6| 6| 0| 3| 5| 9| 4| 2| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
Ectasia | 2 4 4 3 3 3 | 12 3.1|
Hyperplasia, Focal | 2 | 3 2.3|
Hyperplasia, Focal, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 50 |
Cyst | X X | 3 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 50 |
Endometrium, Cyst | 3 | 2 3.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | | 2 3.0|
Myelofibrosis | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 50 |
Mediastinal, Congestion | | 2 2.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 1 2.0|
Hyperplasia, Re Cell | | 4 2.8|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 50 |
Atrophy | 3 | 2 3.0|
Hematopoietic Cell Proliferation | 3 3 3 3 4 | 18 3.2|
Necrosis, Multifocal | 4 | 1 4.0|
Pigmentation | 3 | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M + + + + + + + + + + M + | 45 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + M + + + + + M + + + M + + M + | 44 |
Galactocele | X | 2 |
Hyperplasia, Diffuse | 2 | 1 2.0|
Duct, Ectasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 50 |
Epidermis, Hypoplasia, Focal | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 5| 5| 3| 2| 6| 6| 6| 4| 3| 6| 5| 5| 4| 4| | |
DAY ON TEST | 8| 8| 8| 1| 0| 0| 9| 3| 3| 9| 4| 2| 1| 9| 5| 2| 9| 4| 8| 8| | |
| 2| 2| 1| 3| 2| 0| 2| 4| 9| 6| 6| 0| 3| 5| 9| 4| 2| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acute | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 7 |
Sternum, Osteopetrosis | 4 3 3 | 6 3.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 50 |
Compression | | 2 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 50 |
Congestion | 3 | 2 3.0|
Hyperplasia, Lymphoid | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 35 1.9|
Infiltration Cellular, Histiocyte | 2 2 2 2 2 1 | 6 1.8|
Inflammation, Chronic | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 50 |
Fungus | 3 | 2 2.5|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
Ectasia | 4 4 2 2 | 9 2.8|
Hyperplasia, Focal | 2 | 2 2.0|
Hyperplasia, Focal, Squamous | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 50 |
Hydronephrosis | | 1 2.0|
Nephropathy, Chronic | 3 2 2 1 2 1 1 2 2 2 2 1 2 | 29 1.8|
Renal Tubule, Dilatation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 5| 5| 3| 2| 6| 6| 6| 4| 3| 6| 5| 5| 4| 4| | |
DAY ON TEST | 8| 8| 8| 1| 0| 0| 9| 3| 3| 9| 4| 2| 1| 9| 5| 2| 9| 4| 8| 8| | |
| 2| 2| 1| 3| 2| 0| 2| 4| 9| 6| 6| 0| 3| 5| 9| 4| 2| 7| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Pigmentation | 3 | 2 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Liver | + + + + +|
Basophilic Focus | 1 1 |
Clear Cell Focus | |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | |
Granuloma | |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | |
Necrosis, Coagulative | |
Necrosis, Focal | |
Pigmentation | |
Regeneration, Multifocal | 3|
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| 2 |
Bile Duct, Hyperplasia | 2 2|
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Necrosis, Diffuse | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic, Diffuse | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + +|
Accessory Spleen | |
Atrophy | |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach | + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + +|
Acanthosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + +|
Atrophy | |
Ectasia | 3 |
Granuloma | |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Prostate | + + + + +|
Hemorrhage | |
Hyperplasia, Focal, Glandular | 1 2 |
Hyperplasia, Glandular, Multifocal | 2|
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + +|
Dilatation | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + +|
Atrophy | 3 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + +|
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
Angiectasis | |
Hemorrhage | |
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 4|
Hyperplasia, Focal, Reticulum Cell | |
Necrosis, Multifocal | 4|
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + +|
__________________________________________________________________________|
Skin | + + + + +|
Hemorrhage, Focal | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Carpal, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 2|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Nose | + + + + +|
Fungus | |
Hyperkeratosis | |
Hyperplasia, Glandular | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 1 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Necrosis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Synechia | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | + + + + +|
Abscess | |
Ectasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 3 3 3 3 3|
Cortex, Cyst | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + +|
Hemorrhage | |
Inflammation, Acute | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 6| 5| 3| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|
DAY ON TEST | 8| 8| 8| 8| 9| 8| 8| 5| 8| 3| 8| 8| 8| 3| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0|
| 0| 0| 0| 1| 5| 1| 1| 9| 9| 3| 1| 1| 1| 7| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | 1 |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | |
Granuloma | 2|
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 3 4 |
Necrosis, Focal | |
Pigmentation | 1 |
Regeneration, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia | 2 4 2 2|
Centrilobular, Degeneration, Diffuse | 2 |
Centrilobular, Necrosis, Diffuse | 2 |
__________________________________________________________________________|
Mesentery | + + +|
Inflammation, Chronic, Diffuse | 3 |
Fat, Necrosis | 3 3|
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Atrophy | 2 2 2 2 1 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +|
Acanthosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 6| 5| 3| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|
DAY ON TEST | 8| 8| 8| 8| 9| 8| 8| 5| 8| 3| 8| 8| 8| 3| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0|
| 0| 0| 0| 1| 5| 1| 1| 9| 9| 3| 1| 1| 1| 7| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 3 2 2 2 1 2 2 2 4 3 2 2 3 2 2|
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 3 3 3 3|
Ectasia | 4 3 3 |
Granuloma | 2 |
Hyperplasia, Focal | 3 |
Hyperplasia, Focal, Squamous | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Focal, Glandular | 1 |
Hyperplasia, Glandular, Multifocal | 1 |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + + + + + + + + + + + + M|
Dilatation | |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | 2 1|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 6| 5| 3| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|
DAY ON TEST | 8| 8| 8| 8| 9| 8| 8| 5| 8| 3| 8| 8| 8| 3| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0|
| 0| 0| 0| 1| 5| 1| 1| 9| 9| 3| 1| 1| 1| 7| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hemorrhage | 2 |
Hyperplasia, Re Cell | 2 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | |
Hyperplasia, Focal, Reticulum Cell | |
Necrosis, Multifocal | |
Pigmentation | |
__________________________________________________________________________|
Thymus | M + + + + + + M + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Carpal, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 3 4 X 3 X 2 2 |
Hyperkeratosis | |
Hyperplasia, Glandular | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 6| 5| 3| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|
DAY ON TEST | 8| 8| 8| 8| 9| 8| 8| 5| 8| 3| 8| 8| 8| 3| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0|
| 0| 0| 0| 1| 5| 1| 1| 9| 9| 3| 1| 1| 1| 7| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 3 3 3 3 3 3 3 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Necrosis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Synechia | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Ectasia | 3 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 3 3 3 3 2 2 2 3 2 3 2 1 1 3 3 2 2 3 2 3 3 3 1|
Cortex, Cyst | 4|
Pelvis, Inflammation, Acute | |
Renal Tubule, Pigmentation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Acute | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 5| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
DAY ON TEST | 8| 8| 8| 6| 8| 8| 8| 4| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 5| 4| | |
| 1| 1| 1| 3| 1| 1| 1| 2| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 50 |
Necrosis, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 50 |
Basophilic Focus | 1 1 1 1 2 1 1 1 1 2 1 1 1 | 27 1.1|
Clear Cell Focus | | 1 1.0|
Degeneration, Cystic, Focal | 1 | 1 1.0|
Eosinophilic Focus | 1 2 | 2 1.5|
Granuloma | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 7 |
Mixed Cell Focus | | 1 1.0|
Necrosis, Coagulative | | 2 3.5|
Necrosis, Focal | 1 | 1 1.0|
Pigmentation | | 1 1.0|
Regeneration, Multifocal | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 | 1 1.0|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
Bile Duct, Hyperplasia | | 6 2.3|
Centrilobular, Degeneration, Diffuse | | 1 2.0|
Centrilobular, Necrosis, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Inflammation, Chronic, Diffuse | | 1 3.0|
Fat, Necrosis | 3 3 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 49 |
Accessory Spleen | | 1 |
Atrophy | 2 2 | 7 1.9|
Acinus, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 5| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
DAY ON TEST | 8| 8| 8| 6| 8| 8| 8| 4| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 5| 4| | |
| 1| 1| 1| 3| 1| 1| 1| 2| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 3 2 1 1 2 1 | 35 2.1|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Focal | | 1 1.0|
Hypertrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Focal | 1 | 2 1.0|
Hyperplasia, Multifocal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 49 |
Pars Distalis, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia, Focal | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 3 3 3 | 10 3.1|
Ectasia | 3 | 5 3.2|
Granuloma | | 1 2.0|
Hyperplasia, Focal | 2 | 2 2.5|
Hyperplasia, Focal, Squamous | 1 | 3 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Focal, Glandular | 2 1 1 1 | 7 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 5| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
DAY ON TEST | 8| 8| 8| 6| 8| 8| 8| 4| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 5| 4| | |
| 1| 1| 1| 3| 1| 1| 1| 2| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Glandular, Multifocal | 2 | 3 1.7|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + M | 47 |
Dilatation | 4 | 1 4.0|
Inflammation, Chronic Active | 3 | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 50 |
Atrophy | 4 4 | 3 3.7|
Interstitial Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | | 1 2.0|
Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 50 |
Angiectasis | | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Re Cell | 3 3 3 3 3 3 | 10 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 50 |
Atrophy | | 1 4.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Focal, Reticulum Cell | 2 | 1 2.0|
Necrosis, Multifocal | | 1 4.0|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + M M + M | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage, Focal | 2 | 1 2.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 5| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
DAY ON TEST | 8| 8| 8| 6| 8| 8| 8| 4| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 5| 4| | |
| 1| 1| 1| 3| 1| 1| 1| 2| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Carpal, Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 50 |
Congestion | 4 3 | 4 3.3|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 1 3 2 2 3 2 | 36 2.1|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 50 |
Fungus | 4 4 2 3 1 | 13 2.8|
Hyperkeratosis | 4 3 | 2 3.5|
Hyperplasia, Glandular | 3 | 1 3.0|
Inflammation, Acute | 3 3 4 1 3 2 | 16 2.6|
Metaplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Necrosis | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 4.0|
Synechia | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
Abscess | 3 | 1 3.0|
Ectasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 50 |
Hydronephrosis | 2 | 1 2.0|
Nephropathy, Chronic | 3 3 2 3 4 3 2 2 2 2 3 2 2 3 2 3 | 44 2.5|
Cortex, Cyst | | 1 4.0|
Pelvis, Inflammation, Acute | 3 | 1 3.0|
Renal Tubule, Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 5| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
DAY ON TEST | 8| 8| 8| 6| 8| 8| 8| 4| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 5| 4| | |
| 1| 1| 1| 3| 1| 1| 1| 2| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hemorrhage | 3 | 2 3.5|
Inflammation, Acute | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 3|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 4| 8| 1| 8| 8| 8| 4| 7| 8| 2| 2| 1| 1|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 1| 6| 3| 3| 1| 0| 0| 6| 8| 0| 6| 4| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.063 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | 3 2 1 3 1 1 |
Clear Cell Focus | 2 |
Congestion | |
Degeneration, Cystic, Focal | 2 1 3 |
Degeneration, Cystic, Multifocal | 2 |
Eosinophilic Focus | 1 3 1 2 1 |
Granuloma | 2 |
Hematopoietic Cell Proliferation | 1 2 2 1 |
Infarct, Acute | |
Regeneration, Focal | |
Regeneration, Multifocal | |
Bile Duct, Hyperplasia | 2 2 |
Centrilobular, Degeneration, Diffuse | 2 |
Centrilobular, Necrosis, Diffuse | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
__________________________________________________________________________|
Pharynx | + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 2 2 2 3 3 2 2 2 2|
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 3|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 4| 8| 1| 8| 8| 8| 4| 7| 8| 2| 2| 1| 1|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 1| 6| 3| 3| 1| 0| 0| 6| 8| 0| 6| 4| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.063 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 4 3 |
Hyperplasia, Focal, Squamous | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 2 |
Hyperplasia, Glandular, Multifocal | 2 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + M|
Hyperplasia, Diffuse, Glandular | |
Hyperplasia, Focal, Glandular | 2 |
Hyperplasia, Glandular, Multifocal | |
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 3 |
Pancreatic, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 3|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 4| 8| 1| 8| 8| 8| 4| 7| 8| 2| 2| 1| 1|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 1| 6| 3| 3| 1| 0| 0| 6| 8| 0| 6| 4| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.063 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Hemorrhage | |
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Atrophy | 3 4|
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Diffuse, Reticulum Cell | 3 |
Hyperplasia, Focal, Reticulum Cell | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Compression | X |
Cerebellum, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 4|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 3 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | 4|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Fungus | 2 3 1 1 2 |
Hyperkeratosis | 3 3 4 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 3|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 4| 8| 1| 8| 8| 8| 4| 7| 8| 2| 2| 1| 1|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 1| 6| 3| 3| 1| 0| 0| 6| 8| 0| 6| 4| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.063 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 2 1 3 |
Metaplasia, Squamous | 4 |
Necrosis, Multifocal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Ectasia | 1 1 2 2 3 |
Hyperplasia, Focal, Squamous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 4 1 1 3 3 2 3 3 2 2 2 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Pigmentation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Hemorrhage | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 4| 6| 6| 5| 5| 2| 6| 6| 6| 5| 4| | |
DAY ON TEST | 8| 6| 3| 6| 1| 8| 4| 9| 7| 3| 6| 2| 9| 7| 9| 4| 4| 1| 4| 2| | |
| 0| 8| 2| 6| 2| 0| 6| 2| 9| 5| 0| 0| 1| 8| 3| 6| 6| 4| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.063 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 35 |
Inflammation, Acute | 4 | 1 4.0|
Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 35 |
Basophilic Focus | 2 2 1 | 9 1.8|
Clear Cell Focus | 1 | 2 1.5|
Congestion | 4 | 1 4.0|
Degeneration, Cystic, Focal | | 3 2.0|
Degeneration, Cystic, Multifocal | 1 | 2 1.5|
Eosinophilic Focus | 1 3 | 7 1.7|
Granuloma | | 1 2.0|
Hematopoietic Cell Proliferation | | 4 1.5|
Infarct, Acute | 4 | 1 4.0|
Regeneration, Focal | 3 3 | 2 3.0|
Regeneration, Multifocal | 4 3 3 | 3 3.3|
Bile Duct, Hyperplasia | | 2 2.0|
Centrilobular, Degeneration, Diffuse | | 1 2.0|
Centrilobular, Necrosis, Diffuse | 3 2 4 | 3 3.0|
Centrilobular, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 6 |
Fat, Necrosis | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 35 |
Atrophy | 2 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Pharynx | + + + + + + | 9 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 34 |
__________________________________________________________________________|____________|
Tongue | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 4| 6| 6| 5| 5| 2| 6| 6| 6| 5| 4| | |
DAY ON TEST | 8| 6| 3| 6| 1| 8| 4| 9| 7| 3| 6| 2| 9| 7| 9| 4| 4| 1| 4| 2| | |
| 0| 8| 2| 6| 2| 0| 6| 2| 9| 5| 0| 0| 1| 8| 3| 6| 6| 4| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.063 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 35 |
Cardiomyopathy, Chronic | 3 2 2 2 2 2 3 2 2 2 2 2 2 2 | 25 2.2|
Atrium, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 35 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 35 |
Hyperplasia, Focal | 2 2 | 2 2.0|
Hyperplasia, Multifocal | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 34 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
Follicular Cell, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
Atrophy | 3 3 3 3 3 | 6 3.0|
Ectasia | 4 2 | 4 3.3|
Hyperplasia, Focal, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 35 |
Hyperplasia, Focal, Glandular | 2 1 1 | 4 1.5|
Hyperplasia, Glandular, Multifocal | 2 | 3 2.0|
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + M + + + + M + + + + + | 32 |
Hyperplasia, Diffuse, Glandular | 3 | 1 3.0|
Hyperplasia, Focal, Glandular | | 1 2.0|
Hyperplasia, Glandular, Multifocal | 2 | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 35 |
Atrophy | 4 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 4| 6| 6| 5| 5| 2| 6| 6| 6| 5| 4| | |
DAY ON TEST | 8| 6| 3| 6| 1| 8| 4| 9| 7| 3| 6| 2| 9| 7| 9| 4| 4| 1| 4| 2| | |
| 0| 8| 2| 6| 2| 0| 6| 2| 9| 5| 0| 0| 1| 8| 3| 6| 6| 4| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.063 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 35 |
Hyperplasia | 3 3 2 3 2 2 3 3 3 | 14 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 35 |
Mediastinal, Angiectasis | 4 | 1 4.0|
Mediastinal, Hemorrhage | 3 | 1 3.0|
Mediastinal, Pigmentation | | 1 3.0|
Pancreatic, Angiectasis | 4 | 1 4.0|
Renal, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 35 |
Angiectasis | 4 | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 35 |
Angiectasis | 4 | 1 4.0|
Atrophy | 3 | 1 3.0|
Hemorrhage | 3 4 | 2 3.5|
Hyperplasia, Re Cell | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 35 |
Atrophy | 3 | 3 3.3|
Hematopoietic Cell Proliferation | 2 | 3 2.7|
Hyperplasia, Diffuse, Reticulum Cell | | 1 3.0|
Hyperplasia, Focal, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + + | 34 |
Atrophy | 3 | 1 3.0|
Congestion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + | 34 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 35 |
Cyst Epithelial Inclusion | | 1 |
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | 1 | 1 1.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 4| 6| 6| 5| 5| 2| 6| 6| 6| 5| 4| | |
DAY ON TEST | 8| 6| 3| 6| 1| 8| 4| 9| 7| 3| 6| 2| 9| 7| 9| 4| 4| 1| 4| 2| | |
| 0| 8| 2| 6| 2| 0| 6| 2| 9| 5| 0| 0| 1| 8| 3| 6| 6| 4| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.063 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 35 |
Compression | | 1 |
Cerebellum, Necrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 35 |
Congestion | 3 | 2 3.5|
Hyperplasia, Lymphoid | 2 2 2 2 3 1 2 2 2 | 18 2.1|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 35 |
Fungus | 2 2 4 4 | 9 2.3|
Hyperkeratosis | 4 | 4 3.5|
Inflammation, Acute | 4 3 4 4 | 8 2.9|
Metaplasia, Squamous | 3 2 | 3 3.0|
Necrosis, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 35 |
Ectasia | 1 3 3 1 1 3 | 11 1.9|
Hyperplasia, Focal, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 35 |
Nephropathy, Chronic | 3 2 2 3 3 3 2 2 3 2 1 1 3 2 2 | 28 2.4|
Renal Tubule, Hyperplasia, Focal | 1 | 1 1.0|
Renal Tubule, Pigmentation | 3 3 | 3 3.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 35 |
Hemorrhage | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 0| 2| 8| 4| 3| 5| 5| 8| 4| 4| 3| 0| 4| 4| 2| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 3| 1| 1| 0| 8| 8| 1| 6| 0| 8| 5| 6| 0| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + +|
Erosion | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 1 |
Clear Cell Focus | 3 |
Congestion | |
Degeneration, Cystic, Focal | 2 |
Degeneration, Cystic, Multifocal | 3 1 |
Eosinophilic Focus | 4 3 |
Granuloma | |
Hematopoietic Cell Proliferation | 2 |
Infarct, Acute | |
Mixed Cell Focus | |
Necrosis, Coagulative | |
Necrosis, Focal | 2 2 |
Necrosis, Multifocal | |
Pigmentation | 2 |
Regeneration, Diffuse | 4 |
Regeneration, Focal | |
Regeneration, Multifocal | 3 |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | 1 |
Vacuolization Cytoplasmic, Multifocal| 2 |
Bile Duct, Hyperplasia | 2|
Centrilobular, Degeneration, Diffuse | 3 4 |
Centrilobular, Necrosis, Diffuse | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Thrombosis | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Pharynx | + + + +|
Palate, Hyperkeratosis, Diffuse | |
Palate, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 0| 2| 8| 4| 3| 5| 5| 8| 4| 4| 3| 0| 4| 4| 2| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 3| 1| 1| 0| 8| 8| 1| 6| 0| 8| 5| 6| 0| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Acanthosis | |
Erosion, Focal | |
Erosion, Multifocal | 3 |
Inflammation, Multifocal, Membranous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Erosion, Focal | |
Erosion, Multifocal | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 3 2 2 2 3 2 2 3|
Atrium, Thrombosis | X X X |
Epicardium, Hemorrhage, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
Necrosis, Acute | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 0| 2| 8| 4| 3| 5| 5| 8| 4| 4| 3| 0| 4| 4| 2| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 3| 1| 1| 0| 8| 8| 1| 6| 0| 8| 5| 6| 0| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 2 |
Ectasia | 3 4 3 3 3 2 |
Hyperplasia, Focal, Squamous | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + M + + + + + +|
Hyperplasia, Focal, Glandular | 2 |
Hyperplasia, Glandular, Multifocal | 2 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 2|
__________________________________________________________________________|
Seminal Vesicle | + M + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Glandular | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Atrophy | 1 3 |
Interstitial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 |
Hypoplasia | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 3 |
Mediastinal, Hemorrhage | 4 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + M +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Re Cell | 3 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Atrophy | 3 3|
Congestion | |
Fibrosis, Multifocal | 2 |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Focal, Reticulum Cell | 3 |
Hyperplasia, Multifocal, Reticulum | |
Cell | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + M M + M + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 0| 2| 8| 4| 3| 5| 5| 8| 4| 4| 3| 0| 4| 4| 2| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 3| 1| 1| 0| 8| 8| 1| 6| 0| 8| 5| 6| 0| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + +|
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | 4 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 3 3|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Fungus | 4 4 |
Hyperkeratosis | 4 4 |
Hyperplasia, Glandular | |
Inflammation, Acute | 3 4 4 4 |
Metaplasia, Squamous | 3 |
Necrosis, Diffuse | |
Necrosis, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | +|
Atrophy | 4|
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 6| 6| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 0| 2| 8| 4| 3| 5| 5| 8| 4| 4| 3| 0| 4| 4| 2| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 2| 3| 1| 1| 0| 8| 8| 1| 6| 0| 8| 5| 6| 0| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Ectasia | 2 3 |
Hyperplasia, Focal, Squamous | |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 3 2 2 3 3 2 1 2 3 3 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Hemorrhage | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 6| 6| 6| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 8| 7| 7| 6| 7| 8| 4| 7| 0| 3| 2| 9| 0| 7| 8| 8| 3| 3| 2| 4| 1| 5| 0| 7|
| 1| 1| 0| 4| 0| 9| 1| 6| 0| 6| 7| 8| 5| 5| 2| 1| 0| 3| 2| 6| 6| 7| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + A + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + A + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 1 2 2 1|
Clear Cell Focus | 2 1 |
Congestion | 3 4 |
Degeneration, Cystic, Focal | 4 |
Degeneration, Cystic, Multifocal | 1 2 2 1 |
Eosinophilic Focus | 2 1 2 1 1 |
Granuloma | 1 |
Hematopoietic Cell Proliferation | 2 |
Infarct, Acute | |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 4 3 |
Necrosis, Focal | |
Necrosis, Multifocal | 3 |
Pigmentation | |
Regeneration, Diffuse | |
Regeneration, Focal | |
Regeneration, Multifocal | 2 4 |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia | 3 |
Centrilobular, Degeneration, Diffuse | 3 |
Centrilobular, Necrosis, Diffuse | 4 2 |
__________________________________________________________________________|
Mesentery | + + + |
Thrombosis | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
__________________________________________________________________________|
Pharynx | + + + + + + + + |
Palate, Hyperkeratosis, Diffuse | |
Palate, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 6| 6| 6| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 8| 7| 7| 6| 7| 8| 4| 7| 0| 3| 2| 9| 0| 7| 8| 8| 3| 3| 2| 4| 1| 5| 0| 7|
| 1| 1| 0| 4| 0| 9| 1| 6| 0| 6| 7| 8| 5| 5| 2| 1| 0| 3| 2| 6| 6| 7| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Erosion, Focal | |
Erosion, Multifocal | |
Inflammation, Multifocal, Membranous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 1 |
Erosion, Multifocal | 3 |
__________________________________________________________________________|
Tongue | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 2 2 3 3 2 3 2 2 2 3 2 2 2 3 2 3 2 2|
Atrium, Thrombosis | X X X X X |
Epicardium, Hemorrhage, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Necrosis, Acute | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 6| 6| 6| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 8| 7| 7| 6| 7| 8| 4| 7| 0| 3| 2| 9| 0| 7| 8| 8| 3| 3| 2| 4| 1| 5| 0| 7|
| 1| 1| 0| 4| 0| 9| 1| 6| 0| 6| 7| 8| 5| 5| 2| 1| 0| 3| 2| 6| 6| 7| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 3 3 |
Ectasia | 4 3 4 3 3|
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 2 1 1 2 |
Hyperplasia, Glandular, Multifocal | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + M + M + M + + + + + + + + M M|
Hyperplasia, Diffuse, Glandular | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 3 4 |
Interstitial Cell, Hyperplasia | 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + A + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 2 3 3 3 2 3 3 |
Hypoplasia | |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + A + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | 4 |
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + A + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Re Cell | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | 4 3 |
Congestion | |
Fibrosis, Multifocal | |
Hematopoietic Cell Proliferation | 4 2 3 |
Hyperplasia, Focal, Reticulum Cell | |
Hyperplasia, Multifocal, Reticulum | |
Cell | |
__________________________________________________________________________|
Thymus | + + + M + M + + + M M + + + + M + + + M + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 6| 6| 6| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 8| 7| 7| 6| 7| 8| 4| 7| 0| 3| 2| 9| 0| 7| 8| 8| 3| 3| 2| 4| 1| 5| 0| 7|
| 1| 1| 0| 4| 0| 9| 1| 6| 0| 6| 7| 8| 5| 5| 2| 1| 0| 3| 2| 6| 6| 7| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M + + + + + M + + + + + + + + + + + + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | 2 |
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 2 4 2 1 2 2 2 2 2 2 3 3 2 2 2|
Infiltration Cellular, Histiocyte | 2 2 2 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 4 2 2 3 4 |
Hyperkeratosis | |
Hyperplasia, Glandular | |
Inflammation, Acute | 2 3 4 3 2 2 3 3|
Metaplasia, Squamous | |
Necrosis, Diffuse | |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 6| 6| 6| 6| 6| 5| 5| 4|
DAY ON TEST | 8| 8| 7| 7| 6| 7| 8| 4| 7| 0| 3| 2| 9| 0| 7| 8| 8| 3| 3| 2| 4| 1| 5| 0| 7|
| 1| 1| 0| 4| 0| 9| 1| 6| 0| 6| 7| 8| 5| 5| 2| 1| 0| 3| 2| 6| 6| 7| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.125 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Ectasia | 3 3 |
Hyperplasia, Focal, Squamous | 1 2 1 1 |
Hyperplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 2 2 3 3 3 2 1 3 2 2 3 3 1 2 3 3 3 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3|
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 1| 8| 7| 5| 7| 7| 3| 7| 7| 8| 3| 0| 8| 7| 8| 2| 2| 1| 0| 8| 8| 7| 4| 4| |
| 2| 1| 3| 7| 1| 3| 2| 2| 9| 2| 0| 3| 6| 5| 5| 0| 6| 3| 9| 5| 0| 0| 0| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 62 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 61 |
Erosion | 2 | 1 2.0|
Inflammation, Acute | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 62 |
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| 61 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Basophilic Focus | 1 1 2 3 3 2 2 2 2 2 | 19 1.8|
Clear Cell Focus | 1 | 4 1.8|
Congestion | 4 | 3 3.7|
Degeneration, Cystic, Focal | | 2 3.0|
Degeneration, Cystic, Multifocal | 2 2| 8 1.8|
Eosinophilic Focus | 1 2 3 3 3 2 3 2| 15 2.2|
Granuloma | | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 1 2| 6 1.5|
Infarct, Acute | 4 | 1 4.0|
Mixed Cell Focus | | 1 1.0|
Necrosis, Coagulative | | 2 3.5|
Necrosis, Focal | 1 | 3 1.7|
Necrosis, Multifocal | | 1 3.0|
Pigmentation | | 1 2.0|
Regeneration, Diffuse | | 1 4.0|
Regeneration, Focal | 3 | 1 3.0|
Regeneration, Multifocal | | 3 3.0|
Thrombosis | X X | 2 |
Vacuolization Cytoplasmic, Focal | 2 3 | 3 2.0|
Vacuolization Cytoplasmic, Multifocal| 1 2 | 3 1.7|
Bile Duct, Hyperplasia | | 2 2.5|
Centrilobular, Degeneration, Diffuse | 2 3 2 3| 7 2.9|
Centrilobular, Necrosis, Diffuse | 4 | 4 3.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Thrombosis | X | 1 |
Fat, Necrosis | 3 3 3 | 7 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 1| 8| 7| 5| 7| 7| 3| 7| 7| 8| 3| 0| 8| 7| 8| 2| 2| 1| 0| 8| 8| 7| 4| 4| |
| 2| 1| 3| 7| 1| 3| 2| 2| 9| 2| 0| 3| 6| 5| 5| 0| 6| 3| 9| 5| 0| 0| 0| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Atrophy | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + +| 23 |
Palate, Hyperkeratosis, Diffuse | 4 | 1 4.0|
Palate, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Acanthosis | | 1 2.0|
Erosion, Focal | 2 | 1 2.0|
Erosion, Multifocal | | 1 3.0|
Inflammation, Multifocal, Membranous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Erosion, Focal | 2 | 3 1.7|
Erosion, Multifocal | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Tongue | + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Cardiomyopathy, Chronic | 2 2 2 2 2 3 2 2 3 2 3 3 2 2 2 2 2 2 2| 49 2.3|
Atrium, Thrombosis | X X X X X X X X X| 17 |
Epicardium, Hemorrhage, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Hyperplasia, Focal | 2 4 | 2 3.0|
Hypertrophy, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia, Multifocal | | 1 2.0|
Necrosis, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 63 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 63 |
Pars Distalis, Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 1| 8| 7| 5| 7| 7| 3| 7| 7| 8| 3| 0| 8| 7| 8| 2| 2| 1| 0| 8| 8| 7| 4| 4| |
| 2| 1| 3| 7| 1| 3| 2| 2| 9| 2| 0| 3| 6| 5| 5| 0| 6| 3| 9| 5| 0| 0| 0| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
C-Cell, Hyperplasia, Focal | 3 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Atrophy | 3 3 3 3 3 3 3| 12 2.9|
Ectasia | 2 3 3 3 | 15 3.1|
Hyperplasia, Focal, Squamous | 2 | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Hyperplasia, Focal, Glandular | 2| 6 1.7|
Hyperplasia, Glandular, Multifocal | | 2 1.5|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | | 4 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + M + + + + + + + + + + + + + + + +| 57 |
Hyperplasia, Diffuse, Glandular | 3 | 2 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Atrophy | 3 | 8 3.1|
Interstitial Cell, Hyperplasia | 1 | 9 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 63 |
Hyperplasia | 3 2 3 3 2 | 20 2.8|
Hypoplasia | 4 | 2 3.5|
Myelofibrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Mediastinal, Congestion | | 2 3.0|
Mediastinal, Hemorrhage | | 2 4.0|
Mediastinal, Pigmentation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 62 |
Angiectasis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 1| 8| 7| 5| 7| 7| 3| 7| 7| 8| 3| 0| 8| 7| 8| 2| 2| 1| 0| 8| 8| 7| 4| 4| |
| 2| 1| 3| 7| 1| 3| 2| 2| 9| 2| 0| 3| 6| 5| 5| 0| 6| 3| 9| 5| 0| 0| 0| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Re Cell | 2 3 | 7 2.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Atrophy | | 4 3.3|
Congestion | 3 | 1 3.0|
Fibrosis, Multifocal | | 1 2.0|
Hematopoietic Cell Proliferation | 3 4 3 3 3| 10 3.1|
Hyperplasia, Focal, Reticulum Cell | | 1 3.0|
Hyperplasia, Multifocal, Reticulum | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + + M + + + + + + M + + + +| 51 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 59 |
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Cyst Epithelial Inclusion | X X | 4 |
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | 2 | 3 2.7|
Subcutaneous Tissue, Edema | 3 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Congestion | | 3 3.3|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 39 2.1|
Infiltration Cellular, Histiocyte | 2 | 4 2.0|
Inflammation, Acute | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 1| 8| 7| 5| 7| 7| 3| 7| 7| 8| 3| 0| 8| 7| 8| 2| 2| 1| 0| 8| 8| 7| 4| 4| |
| 2| 1| 3| 7| 1| 3| 2| 2| 9| 2| 0| 3| 6| 5| 5| 0| 6| 3| 9| 5| 0| 0| 0| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.125 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Fungus | 2 4 2 3 4 | 13 3.1|
Hyperkeratosis | | 2 4.0|
Hyperplasia, Glandular | 3 | 1 3.0|
Inflammation, Acute | 1 4 4 2 3 2 | 18 2.9|
Metaplasia, Squamous | | 1 3.0|
Necrosis, Diffuse | 4 | 1 4.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 64 |
Ectasia | 1 3 2 2 | 8 2.4|
Hyperplasia, Focal, Squamous | 1 | 5 1.2|
Hyperplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Nephropathy, Chronic | 2 3 1 3 1 2 3 2 3 2 2 2 3 2 2 3 2 3 3 2 3 3| 56 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Hemorrhage | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 5| 4| 3| 0| 0|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 3| 8| 8| 8| 8| 8| 8| 8| 1| 8| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
Necrosis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
Inflammation, Acute, Multifocal | |
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
Diverticulum | |
__________________________________________________________________________|
Liver | + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 2 |
Degeneration, Cystic, Focal | |
Degeneration, Cystic, Multifocal | |
Eosinophilic Focus | 2 2 |
Granuloma | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Infarct, Focal | |
Infarct, Subacute | |
Mixed Cell Focus | |
Necrosis, Focal | |
Necrosis | |
Necrosis, Multifocal | |
Regeneration, Diffuse | |
Regeneration, Focal | |
Regeneration, Multifocal | |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic | |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Cyst | |
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Necrosis, Diffuse | 4 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + +|
Atrophy | |
Acinus, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 5| 4| 3| 0| 0|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 3| 8| 8| 8| 8| 8| 8| 8| 1| 8| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pharynx | + |
Palate, Hyperkeratosis, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + +|
Acanthosis | |
Hyperplasia, Focal | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + +|
Erosion, Focal | |
Erosion, Multifocal | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
Cardiomyopathy, Chronic | 2 2 2 1 |
Embolus | |
Inflammation, Acute, Multifocal | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + +|
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + +|
Pars Distalis, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 5| 4| 3| 0| 0|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 3| 8| 8| 8| 8| 8| 8| 8| 1| 8| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ectasia | 3 3 |
Hyperplasia, Focal | 1 |
Hyperplasia, Focal, Squamous | |
Hyperplasia | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + +|
Hyperplasia, Focal, Glandular | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | M + M M M|
Hyperplasia, Diffuse, Glandular | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + +|
Hyperplasia | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + +|
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
Hemorrhage | 3 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 2 |
__________________________________________________________________________|
Thymus | + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + +|
__________________________________________________________________________|
Skin | + + + + +|
Cyst Epithelial Inclusion | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Multifocal | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 5| 4| 3| 0| 0|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 3| 8| 8| 8| 8| 8| 8| 8| 1| 8| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Gliosis, Focal | |
Inflammation, Acute, Multifocal | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + +|
Congestion | |
Hemorrhage | 2 2|
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + +|
Fungus | |
Hyperkeratosis | |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + +|
Ectasia | 3 |
Hyperplasia, Focal, Squamous | |
Hypertrophy, Diffuse | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + +|
Inflammation, Acute, Multifocal | |
Nephropathy, Chronic | 2 3 2 |
Renal Tubule, Degeneration | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 3| 6| 6| 4| 4| 3| 6| 5| 6| 5| 4| 5| 5| 5| 4| 4| 6| 6| 5| 5| 4|
DAY ON TEST | 4| 4| 4| 5| 1| 4| 2| 6| 0| 7| 8| 4| 0| 2| 6| 3| 0| 0| 9| 7| 8| 1| 7| 9| 9|
| 6| 6| 6| 6| 7| 5| 1| 3| 8| 2| 0| 7| 0| 1| 0| 5| 6| 5| 5| 9| 0| 2| 9| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 4 1 1 1 2 3 2 2 1 4 2 2 |
Clear Cell Focus | 2 |
Degeneration, Cystic, Focal | 2 3 |
Degeneration, Cystic, Multifocal | 3 3 |
Eosinophilic Focus | 3 2 4 1 1 4 1 1 2 2 2 3 |
Granuloma | 3 |
Hematopoietic Cell Proliferation | 1 2 1 1 2 |
Hepatodiaphragmatic Nodule | X |
Infarct, Focal | |
Infarct, Subacute | |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Necrosis | |
Necrosis, Multifocal | |
Regeneration, Diffuse | 3 |
Regeneration, Focal | |
Regeneration, Multifocal | 3 3 3 4 3 4 4|
Thrombosis | X |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic | 3 |
Vacuolization Cytoplasmic, Multifocal| 1 2 3 |
Bile Duct, Cyst | |
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Necrosis, Diffuse | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinus, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 3| 6| 6| 4| 4| 3| 6| 5| 6| 5| 4| 5| 5| 5| 4| 4| 6| 6| 5| 5| 4|
DAY ON TEST | 4| 4| 4| 5| 1| 4| 2| 6| 0| 7| 8| 4| 0| 2| 6| 3| 0| 0| 9| 7| 8| 1| 7| 9| 9|
| 6| 6| 6| 6| 7| 5| 1| 3| 8| 2| 0| 7| 0| 1| 0| 5| 6| 5| 5| 9| 0| 2| 9| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pharynx | + + + + + + + + + |
Palate, Hyperkeratosis, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperplasia, Focal | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Erosion, Multifocal | 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 1|
Embolus | |
Inflammation, Acute, Multifocal | |
Atrium, Thrombosis | X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | M + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 3| 6| 6| 4| 4| 3| 6| 5| 6| 5| 4| 5| 5| 5| 4| 4| 6| 6| 5| 5| 4|
DAY ON TEST | 4| 4| 4| 5| 1| 4| 2| 6| 0| 7| 8| 4| 0| 2| 6| 3| 0| 0| 9| 7| 8| 1| 7| 9| 9|
| 6| 6| 6| 6| 7| 5| 1| 3| 8| 2| 0| 7| 0| 1| 0| 5| 6| 5| 5| 9| 0| 2| 9| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ectasia | 3 3 3 3 3 3 |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | |
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 1 |
Inflammation, Chronic Active | 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + M M + + + M + + + + + + + + + + +|
Hyperplasia, Diffuse, Glandular | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 1 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 3 3 |
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Re Cell | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Hematopoietic Cell Proliferation | 3 3 2 3 2 3 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M + + + + + M + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M + + + + + + + M + + + + + + M + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Multifocal | 1 1|
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Fibrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 3| 6| 6| 4| 4| 3| 6| 5| 6| 5| 4| 5| 5| 5| 4| 4| 6| 6| 5| 5| 4|
DAY ON TEST | 4| 4| 4| 5| 1| 4| 2| 6| 0| 7| 8| 4| 0| 2| 6| 3| 0| 0| 9| 7| 8| 1| 7| 9| 9|
| 6| 6| 6| 6| 7| 5| 1| 3| 8| 2| 0| 7| 0| 1| 0| 5| 6| 5| 5| 9| 0| 2| 9| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis, Focal | 2 |
Inflammation, Acute, Multifocal | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 2 4 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Hyperkeratosis | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 4 4 3 |
Hyperplasia, Focal, Squamous | 2 1 |
Hypertrophy, Diffuse | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
Nephropathy, Chronic | 2 3 3 3 3 3 2 1 2 4 1 3 1 3 2 1 2 2 3 2 3 4 3|
Renal Tubule, Degeneration | 4 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Pigmentation | 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 6| 4| 5| 3| 5| 5| 4| 4| 4| 5| 5| 5| 5| 5| | |
DAY ON TEST | 2| 1| 8| 6| 6| 5| 5| 5| 0| 7| 7| 0| 6| 6| 4| 4| 3| 6| 6| 2| | |
| 4| 3| 3| 5| 1| 9| 6| 2| 2| 2| 0| 6| 5| 0| 9| 3| 9| 5| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 50 |
Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 50 |
Necrosis | 3 | 1 3.0|
Parasite Metazoan | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Acute, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 50 |
Diverticulum | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 50 |
Basophilic Focus | 2 2 2 1 1 2 4 | 21 2.0|
Clear Cell Focus | 2 | 3 2.0|
Degeneration, Cystic, Focal | 3 3 3 | 5 2.8|
Degeneration, Cystic, Multifocal | | 2 3.0|
Eosinophilic Focus | 1 2 2 1 2 3 1 2 1 | 23 2.0|
Granuloma | 1 | 3 2.0|
Hematopoietic Cell Proliferation | 1 1 2 3 1 2 3 2 | 13 1.7|
Hepatodiaphragmatic Nodule | | 2 |
Infarct, Focal | 2 | 1 2.0|
Infarct, Subacute | 4 | 1 4.0|
Mixed Cell Focus | 4 | 1 4.0|
Necrosis, Focal | 1 | 2 1.5|
Necrosis | 2 | 1 2.0|
Necrosis, Multifocal | 3 | 1 3.0|
Regeneration, Diffuse | 3 3 | 3 3.0|
Regeneration, Focal | 3 | 1 3.0|
Regeneration, Multifocal | 4 3 4 4 | 11 3.5|
Thrombosis | | 1 |
Vacuolization Cytoplasmic, Focal | 1 | 1 1.0|
Vacuolization Cytoplasmic | | 1 3.0|
Vacuolization Cytoplasmic, Multifocal| 1 3 2 | 6 2.0|
Bile Duct, Cyst | X | 1 |
Centrilobular, Degeneration, Diffuse | 3 3 2 3 | 4 2.8|
Centrilobular, Necrosis, Diffuse | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 6| 4| 5| 3| 5| 5| 4| 4| 4| 5| 5| 5| 5| 5| | |
DAY ON TEST | 2| 1| 8| 6| 6| 5| 5| 5| 0| 7| 7| 0| 6| 6| 4| 4| 3| 6| 6| 2| | |
| 4| 3| 3| 5| 1| 9| 6| 2| 2| 2| 0| 6| 5| 0| 9| 3| 9| 5| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Necrosis | 3 3 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 50 |
Atrophy | 2 2 | 3 2.0|
Acinus, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + | 20 |
Palate, Hyperkeratosis, Focal | 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 50 |
Acanthosis | 3 | 1 3.0|
Hyperplasia, Focal | 3 | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 50 |
Erosion, Focal | 2 | 1 2.0|
Erosion, Multifocal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 2 3 2 2 2 1 1 2 2 1 2 3 3 | 39 1.9|
Embolus | 3 | 1 3.0|
Inflammation, Acute, Multifocal | 2 | 1 2.0|
Atrium, Thrombosis | X X X X X X | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 50 |
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Focal | 2 2 | 2 2.0|
Hyperplasia, Multifocal | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
Pars Distalis, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 6| 4| 5| 3| 5| 5| 4| 4| 4| 5| 5| 5| 5| 5| | |
DAY ON TEST | 2| 1| 8| 6| 6| 5| 5| 5| 0| 7| 7| 0| 6| 6| 4| 4| 3| 6| 6| 2| | |
| 4| 3| 3| 5| 1| 9| 6| 2| 2| 2| 0| 6| 5| 0| 9| 3| 9| 5| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia, Focal | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 3 3 3 3 3 | 10 3.0|
Ectasia | 3 3 3 3 3 3 | 14 3.0|
Hyperplasia, Focal | 3 | 2 2.0|
Hyperplasia, Focal, Squamous | 3 3 | 2 3.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + M + + + + + + + + + | 49 |
Hyperplasia, Focal, Glandular | | 1 1.0|
Inflammation, Chronic Active | 3 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + M + + + + + + + + + + | 42 |
Hyperplasia, Diffuse, Glandular | | 1 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 50 |
Atrophy | 4 4 | 4 4.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 | 9 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 3 3 3 2 3 3 3 3 | 16 2.9|
Myelofibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 50 |
Mediastinal, Hemorrhage | 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Hyperplasia, Re Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 6| 4| 5| 3| 5| 5| 4| 4| 4| 5| 5| 5| 5| 5| | |
DAY ON TEST | 2| 1| 8| 6| 6| 5| 5| 5| 0| 7| 7| 0| 6| 6| 4| 4| 3| 6| 6| 2| | |
| 4| 3| 3| 5| 1| 9| 6| 2| 2| 2| 0| 6| 5| 0| 9| 3| 9| 5| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Re Cell | 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 50 |
Atrophy | 3 | 3 3.0|
Hematopoietic Cell Proliferation | 2 3 4 3 3 4 4 3 | 17 2.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + M + + + + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + | 42 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 50 |
Cyst Epithelial Inclusion | 4 | 1 4.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Multifocal | 1 | 3 1.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
Subcutaneous Tissue, Fibrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 50 |
Gliosis, Focal | | 1 2.0|
Inflammation, Acute, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 50 |
Congestion | | 1 3.0|
Hemorrhage | 3 | 3 2.3|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 3 2 2 | 26 2.1|
Infiltration Cellular, Histiocyte | 2 4 2 2 | 8 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + M + + + + + + + + + + + + + | 49 |
Fungus | 3 3 3 | 4 3.3|
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Acute | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05169-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 04/29/97
Route: DOSED WATER Time: 08:43:54
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 5| 6| 6| 4| 5| 3| 5| 5| 4| 4| 4| 5| 5| 5| 5| 5| | |
DAY ON TEST | 2| 1| 8| 6| 6| 5| 5| 5| 0| 7| 7| 0| 6| 6| 4| 4| 3| 6| 6| 2| | |
| 4| 3| 3| 5| 1| 9| 6| 2| 2| 2| 0| 6| 5| 0| 9| 3| 9| 5| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 50 |
Ectasia | 3 2 3 4 3 2 | 12 3.0|
Hyperplasia, Focal, Squamous | 1 1 1 | 5 1.2|
Hypertrophy, Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Acute, Multifocal | 3 | 1 3.0|
Nephropathy, Chronic | 3 3 3 3 2 3 3 2 1 4 2 1 2 3 2 | 41 2.4|
Renal Tubule, Degeneration | 3 | 2 3.5|
Renal Tubule, Hyperplasia, Focal | 1 | 1 1.0|
Renal Tubule, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 50 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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