TDMS Study 05172-01 Pathology Tables
NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 Facility: Hazleton Laboratories America, Inc. Chemical CAS #: 20325400 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + +| Peyer's Patch, Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + +| Peyer's Patch, Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Mesentery | | Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Pharynx | + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X | Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | Bilateral, Adenoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | | Polyp Stromal, Multiple | | Sarcoma Stromal | X | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + +| Iliac, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Thymus | + + M + + + + M + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X X X | Fibroadenoma, Multiple | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Cerebrum, Carcinoma, Metastatic, | | Pituitary Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + +| Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Lipoma | | __________________________________________________________________________| Ureter | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| DAY ON TEST | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4| | 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Leukemia Mononuclear | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Pharynx | | Palate, Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Pheochromocytoma Benign | X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| DAY ON TEST | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4| | 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X | Pars Distalis, Carcinoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X| C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | Bilateral, Adenoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | X | Polyp Stromal, Multiple | | Sarcoma Stromal | | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Leukemia Mononuclear | X| Mediastinal, Leukemia Mononuclear | X X X X X| Pancreatic, Leukemia Mononuclear | X X X| __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + M + + + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Fibroadenoma | X X X X | Fibroadenoma, Multiple | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| DAY ON TEST | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4| | 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Cerebrum, Carcinoma, Metastatic, | | Pituitary Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Lipoma | | __________________________________________________________________________| Ureter | + + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5| | | | 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 60 | Peyer's Patch, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 60 | Peyer's Patch, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X X X X X X | 20 | __________________________________________________________________________|____________| Mesentery | + + | 6 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Pharynx | | 1 | Palate, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 9 | Pheochromocytoma Benign | X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5| | | | 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 60 | Adenoma | X | 1 | Leukemia Mononuclear | X X | 2 | Pars Distalis, Adenoma | X X X X | 14 | Pars Distalis, Carcinoma | X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 | C-Cell, Adenoma | X | 4 | C-Cell, Carcinoma | | 1 | Follicular Cell, Carcinoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + M M + + + + + + | 58 | Adenoma | X X | 4 | Carcinoma | | 2 | Bilateral, Adenoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 1 | Polyp Stromal | X X X X | 5 | Polyp Stromal, Multiple | X | 1 | Sarcoma Stromal | | 1 | __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 | Iliac, Leukemia Mononuclear | | 1 | Mediastinal, Leukemia Mononuclear | X X | 7 | Pancreatic, Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 59 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5| | | | 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X X X X X X | 21 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + M | 53 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 59 | Adenocarcinoma | | 1 | Fibroadenoma | X X X X X | 12 | Fibroadenoma, Multiple | X X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 3 | Cerebrum, Carcinoma, Metastatic, | | | Pituitary Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 60 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 5 | Lipoma | X X | 2 | __________________________________________________________________________|____________| Ureter | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5| | | | 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X | 21 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5| DAY ON TEST | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7| | 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 80 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| Descending Colon, Adenocarcinoma | X | __________________________________________________________________________| Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| Adenocarcinoma, Cystic, Mucinous | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + A| Carcinoma, Metastatic, Uterus | X | Leukemia Mononuclear | X X X X X X | Neoplastic Nodule | X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Carcinosarcoma | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5| DAY ON TEST | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7| | 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 80 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X X | Carcinoma | X X X X X X X | Bilateral, Adenoma | X X | Bilateral, Carcinoma | X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Oviduct | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Leukemia Mononuclear | | Polyp Stromal | X X | Polyp Stromal, Multiple | X | Sarcoma Stromal | X | Cervix, Carcinoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X X | Adenoma | | Fibroadenoma | X X X X | Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X | Basal Cell Carcinoma | | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5| DAY ON TEST | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7| | 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 80 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + | Cranium, Carcinoma, Metastatic, | | Zymbal's Gland | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Astrocytoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Leukemia Mononuclear | X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | __________________________________________________________________________| Harderian Gland | + + | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X X X X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | | DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | | | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 44 | Descending Colon, Adenocarcinoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 43 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + A + | 43 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 43 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 43 | Adenocarcinoma, Cystic, Mucinous | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 44 | Carcinoma, Metastatic, Uterus | | 1 | Leukemia Mononuclear | X X X X X X X X | 14 | Neoplastic Nodule | | 1 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + A + | 43 | __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + M + | 44 | Bilateral, Carcinosarcoma | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + A + | 44 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + | 44 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + | 44 | __________________________________________________________________________|____________| Tongue | + | 2 | Squamous Cell Papilloma | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 45 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 45 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 45 | Leukemia Mononuclear | X X | 4 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + | 43 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + M + | 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | | DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | | | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 2 | Pars Distalis, Adenoma | X X X X X | 9 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + | 44 | C-Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + M + + + + + + + + + + + + + + + + | 44 | Adenoma | X X X X X X X | 13 | Carcinoma | X X X X X | 12 | Bilateral, Adenoma | | 2 | Bilateral, Carcinoma | X X X | 5 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Oviduct | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 45 | Adenoma | | 3 | Leukemia Mononuclear | X | 1 | Polyp Stromal | X X X | 5 | Polyp Stromal, Multiple | X X | 3 | Sarcoma Stromal | | 1 | Cervix, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 45 | Iliac, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X X | 3 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + | 44 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 44 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + A + | 44 | Leukemia Mononuclear | X X X X X X X X | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | | DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | | | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + M + + + M + | 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + M + | 43 | Adenocarcinoma | | 2 | Adenoma | X | 1 | Fibroadenoma | X X X X X | 9 | Fibroadenoma, Multiple | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 45 | Basal Cell Adenoma | X | 3 | Basal Cell Carcinoma | X | 1 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + | 5 | Cranium, Carcinoma, Metastatic, | | | Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 45 | Cerebrum, Astrocytoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 45 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 45 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | __________________________________________________________________________|____________| Harderian Gland | | 2 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 45 | Adenoma | X X | 3 | Carcinoma | X X X | 10 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | | DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | | | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 45 | Leukemia Mononuclear | X | 1 | Renal Tubule, Adenoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 45 | Leukemia Mononuclear | X X X X X X X X | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2| DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8| | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma Stromal, Metastatic, Uterus | | Descending Colon, Polyp Adenomatous | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Cystic, Mucinous | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Multiple, Metastatic, | | Uterus | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + | Carcinoma, Multiple, Metastatic, | | Uterus | | Sarcoma Stromal, Metastatic, Uterus | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Pharynx | + | Palate, Squamous Cell Carcinoma | | Palate, Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Benign | X | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2| DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8| | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Carcinoma, Metastatic, Uterus | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X X X X X X X X | Bilateral, Adenoma | | Bilateral, Carcinoma | X X X X X X| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Polyp Stromal | X | Polyp Stromal, Multiple | X | Sarcoma Stromal | | Cervix, Adenoma, Papillary | | __________________________________________________________________________| Vagina | | Mucosa, Polyp | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X | Renal, Carcinoma, Metastatic, Uterus | | Thoracic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Axillary, Renal, Carcinoma, | | Metastatic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2| DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8| | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + M + + M + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X X X X | Adenocarcinoma, Multiple | | Fibroadenoma | X X X | Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Squamous Cell Papilloma | X | Squamous Cell Papilloma, Multiple | | Subcutaneous Tissue, Carcinoma, | | Metastatic | | Subcutaneous Tissue, Squamous Cell | | Carcinoma, Metastatic, Pharynx | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + | __________________________________________________________________________| Skeletal Muscle | | Intercostal, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebellum, Astrocytoma Malignant | X | Meninges, Cerebrum, Nerve, Carcinoma,| | Metastatic, Zymbal's Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Multiple, Metastatic,| | Mammary Gland | | Alveolar/Bronchiolar Adenoma | | Carcinoma, Multiple, Metastatic, | | Uterus | | Carcinoma, Multiple, Metastatic, | | Zymbal's Gland | X | Carcinoma, Metastatic, Clitoral Gland| | Carcinoma, Metastatic, Metastatic | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2| DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8| | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Squamous Cell Carcinoma, Metastatic, | | Pharynx | | Mediastinum, Sarcoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X X X X X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Ureter | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3| DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7| | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma Stromal, Metastatic, Uterus | | Descending Colon, Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + A + + + + + + + + + + +| Adenocarcinoma, Cystic, Mucinous | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Multiple, Metastatic, | | Uterus | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Mesentery | + +| Carcinoma, Multiple, Metastatic, | | Uterus | | Sarcoma Stromal, Metastatic, Uterus | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Pharynx | + + | Palate, Squamous Cell Carcinoma | | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Benign | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3| DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7| | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Carcinoma, Metastatic, Uterus | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X | Carcinoma | X X X X X X X X X X X X| Bilateral, Adenoma | X | Bilateral, Carcinoma | X X X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Polyp Stromal | X X X | Polyp Stromal, Multiple | | Sarcoma Stromal | | Cervix, Adenoma, Papillary | | __________________________________________________________________________| Vagina | | Mucosa, Polyp | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Carcinoma, Metastatic, Uterus | | Thoracic, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Axillary, Renal, Carcinoma, | | Metastatic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3| DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7| | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + M M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X X | Adenocarcinoma, Multiple | X | Fibroadenoma | X X X | Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X | Squamous Cell Papilloma | X | Squamous Cell Papilloma, Multiple | X | Subcutaneous Tissue, Carcinoma, | | Metastatic | X | Subcutaneous Tissue, Squamous Cell | | Carcinoma, Metastatic, Pharynx | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + | __________________________________________________________________________| Skeletal Muscle | + | Intercostal, Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebellum, Astrocytoma Malignant | | Meninges, Cerebrum, Nerve, Carcinoma,| | Metastatic, Zymbal's Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Multiple, Metastatic,| | Mammary Gland | | Alveolar/Bronchiolar Adenoma | | Carcinoma, Multiple, Metastatic, | | Uterus | | Carcinoma, Multiple, Metastatic, | | Zymbal's Gland | | Carcinoma, Metastatic, Clitoral Gland| X | Carcinoma, Metastatic, Metastatic | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3| DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7| | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Squamous Cell Carcinoma, Metastatic, | | Pharynx | | Mediastinum, Sarcoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X X X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Ureter | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| | DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| | | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Sarcoma Stromal, Metastatic, Uterus | X | 1 | Descending Colon, Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + + +| 73 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +| 72 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 72 | Adenocarcinoma, Cystic, Mucinous | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Carcinoma, Multiple, Metastatic, | | | Uterus | X | 1 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Mesentery | + + + + + | 8 | Carcinoma, Multiple, Metastatic, | | | Uterus | X | 1 | Sarcoma Stromal, Metastatic, Uterus | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pharynx | + + + | 6 | Palate, Squamous Cell Carcinoma | X | 1 | Palate, Squamous Cell Papilloma | X X | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Tongue | + + +| 5 | Squamous Cell Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| | DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| | | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | X | 3 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + M + +| 70 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X | 5 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | C-Cell, Adenoma | | 2 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | Carcinoma, Metastatic, Uterus | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Adenoma | X X X X | 12 | Carcinoma | X X X X X X | 27 | Bilateral, Adenoma | | 1 | Bilateral, Carcinoma | X X X X | 14 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Carcinoma | X | 1 | Polyp Stromal | X X | 6 | Polyp Stromal, Multiple | | 1 | Sarcoma Stromal | X X | 2 | Cervix, Adenoma, Papillary | X | 1 | __________________________________________________________________________|____________| Vagina | +| 1 | Mucosa, Polyp | X| 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Lumbar, Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| | DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| | | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Mediastinal, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | | 2 | Renal, Carcinoma, Metastatic, Uterus | X | 1 | Thoracic, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | X | 4 | Axillary, Renal, Carcinoma, | | | Metastatic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + M + + + M + + + + + + + + +| 68 | Leukemia Mononuclear | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Adenocarcinoma | X X X X X X X| 13 | Adenocarcinoma, Multiple | | 1 | Fibroadenoma | X X | 8 | Fibroadenoma, Multiple | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Basal Cell Adenoma | | 3 | Squamous Cell Papilloma | | 2 | Squamous Cell Papilloma, Multiple | | 1 | Subcutaneous Tissue, Carcinoma, | | | Metastatic | | 1 | Subcutaneous Tissue, Squamous Cell | | | Carcinoma, Metastatic, Pharynx | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 8 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Intercostal, Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Cerebellum, Astrocytoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| | DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| | | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Meninges, Cerebrum, Nerve, Carcinoma,| | | Metastatic, Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Adenocarcinoma, Multiple, Metastatic,| | | Mammary Gland | X | 1 | Alveolar/Bronchiolar Adenoma | X | 1 | Carcinoma, Multiple, Metastatic, | | | Uterus | X | 1 | Carcinoma, Multiple, Metastatic, | | | Zymbal's Gland | | 1 | Carcinoma, Metastatic, Clitoral Gland| | 1 | Carcinoma, Metastatic, Metastatic | | 1 | Leukemia Mononuclear | X | 4 | Squamous Cell Carcinoma, Metastatic, | | | Pharynx | X | 1 | Mediastinum, Sarcoma | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 5 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Adenoma | X | 4 | Carcinoma | X X X | 17 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Ureter | + + | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | X | 12 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + +| Descending Colon, Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + A + + + + +| Adenocarcinoma | | Polyp Adenomatous | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + +| Adenocarcinoma, Cystic, Mucinous | | Carcinoma, Metastatic, Urinary | | Bladder | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + +| Adenocarcinoma, Cystic, Mucinous | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Urinary | | Bladder | X | Hepatocellular Carcinoma | | Leukemia Mononuclear | | Neoplastic Nodule, Multiple | X | __________________________________________________________________________| Mesentery | + + | Carcinoma, Multiple, Metastatic, | | Urinary Bladder | X | Sarcoma Stromal, Metastatic, Uterus | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Urinary | | Bladder | X | __________________________________________________________________________| Pharynx | | Palate, Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + A + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + A + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Carcinoma | X | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + A + + + + +| C-Cell, Adenoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + + + M + + + + +| Adenoma | X X X X | Carcinoma | X X X X X| Carcinoma, Metastatic, Clitoral Gland| X | Bilateral, Adenoma | X | Bilateral, Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + A + + + + +| Carcinoma, Metastatic, Urinary | | Bladder | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + +| Adenoma | | Deciduoma Benign | | Polyp Stromal | | Sarcoma Stromal | | Cervix, Sarcoma Stromal, Metastatic, | | Uterus | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + A + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + +| Adenocarcinoma | X X X X| Adenocarcinoma, Multiple | | Adenoma | X X | Fibroadenoma | | Mixed Tumor Malignant | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | | __________________________________________________________________________| Skeletal Muscle | + | Diaphragm, Carcinoma, Metastatic, | | Urinary Bladder | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Urinary | | Bladder | X | Leukemia Mononuclear | | Mixed Tumor Malignant, Multiple, | | Metastatic, Mammary Gland | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X X X X | Bilateral, Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + +| Renal Tubule, Carcinoma, Metastatic, | | Urinary Bladder | X | Transitional Epithelium, Carcinoma | X | __________________________________________________________________________| Ureter | + | Carcinoma, Metastatic, Urinary | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Bladder | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + +| Sarcoma Stromal, Metastatic, Uterus | | Transitional Epithelium, Carcinoma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3| DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0| | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Descending Colon, Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Polyp Adenomatous | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| Adenocarcinoma, Cystic, Mucinous | | Carcinoma, Metastatic, Urinary | | Bladder | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + + + + + + +| Adenocarcinoma, Cystic, Mucinous | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Urinary | | Bladder | | Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X | Neoplastic Nodule, Multiple | X | __________________________________________________________________________| Mesentery | + + + | Carcinoma, Multiple, Metastatic, | | Urinary Bladder | | Sarcoma Stromal, Metastatic, Uterus | X | __________________________________________________________________________| Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Urinary | | Bladder | | __________________________________________________________________________| Pharynx | + + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3| DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0| | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + M M + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X X X X X X X X X X| Carcinoma, Metastatic, Clitoral Gland| | Bilateral, Adenoma | X X | Bilateral, Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Urinary | | Bladder | | __________________________________________________________________________| Uterus | + + + + + + + A + + + + + + + + + + + + + + + + +| Adenoma | | Deciduoma Benign | | Polyp Stromal | X | Sarcoma Stromal | X | Cervix, Sarcoma Stromal, Metastatic, | | Uterus | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3| DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0| | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X X X X X X | Adenocarcinoma, Multiple | X | Adenoma | | Fibroadenoma | X X | Mixed Tumor Malignant | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + | __________________________________________________________________________| Skeletal Muscle | | Diaphragm, Carcinoma, Metastatic, | | Urinary Bladder | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Urinary | | Bladder | | Leukemia Mononuclear | X | Mixed Tumor Malignant, Multiple, | | Metastatic, Mammary Gland | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X | Bilateral, Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Carcinoma, Metastatic, | | Urinary Bladder | | Transitional Epithelium, Carcinoma | | __________________________________________________________________________| Ureter | | Carcinoma, Metastatic, Urinary | | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3| DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0| | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Bladder | | __________________________________________________________________________| Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +| Sarcoma Stromal, Metastatic, Uterus | X | Transitional Epithelium, Carcinoma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | | DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | | | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 59 | Descending Colon, Polyp Adenomatous | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 59 | Adenocarcinoma | X | 1 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 58 | Adenocarcinoma, Cystic, Mucinous | X | 1 | Carcinoma, Metastatic, Urinary | | | Bladder | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 58 | Adenocarcinoma, Cystic, Mucinous | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 60 | Carcinoma, Metastatic, Urinary | | | Bladder | | 1 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X | 4 | Neoplastic Nodule, Multiple | | 2 | __________________________________________________________________________|____________| Mesentery | + + | 7 | Carcinoma, Multiple, Metastatic, | | | Urinary Bladder | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 59 | Carcinoma, Metastatic, Urinary | | | Bladder | | 1 | __________________________________________________________________________|____________| Pharynx | | 2 | Palate, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Tongue | + + | 4 | Squamous Cell Carcinoma | X | 2 | Squamous Cell Papilloma | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | | DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | | | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 59 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X | 8 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 59 | C-Cell, Adenoma | X | 1 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 55 | Adenoma | X X X X X X | 13 | Carcinoma | X X X X X X X X X X | 26 | Carcinoma, Metastatic, Clitoral Gland| | 1 | Bilateral, Adenoma | | 3 | Bilateral, Carcinoma | X X | 4 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 58 | Carcinoma, Metastatic, Urinary | | | Bladder | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 59 | Adenoma | X X | 2 | Deciduoma Benign | X | 1 | Polyp Stromal | X X X X | 5 | Sarcoma Stromal | | 1 | Cervix, Sarcoma Stromal, Metastatic, | | | Uterus | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | | DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | | | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 58 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Thymus | + + M + + M + + + + + + + M + + + + + M | 54 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 59 | Adenocarcinoma | X X X X X X X X | 18 | Adenocarcinoma, Multiple | X | 2 | Adenoma | | 2 | Fibroadenoma | X X | 4 | Mixed Tumor Malignant | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 60 | Basal Cell Adenoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + | 4 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Diaphragm, Carcinoma, Metastatic, | | | Urinary Bladder | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Urinary | | | Bladder | | 1 | Leukemia Mononuclear | | 1 | Mixed Tumor Malignant, Multiple, | | | Metastatic, Mammary Gland | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | | DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | | | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 60 | Adenoma | X | 3 | Carcinoma | X X X | 10 | Bilateral, Carcinoma | X X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 60 | Renal Tubule, Carcinoma, Metastatic, | | | Urinary Bladder | | 1 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________|____________| Ureter | | 1 | Carcinoma, Metastatic, Urinary | | | Bladder | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 59 | Sarcoma Stromal, Metastatic, Uterus | | 1 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + +| Rectum, Mesothelioma Malignant, | | Metastatic | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + +| Ileum, Jejunum, Mesothelioma | | Malignant, Metastatic, Testes | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Mesentery | + + + + + | Mesothelioma Malignant, Multiple, | | Metastatic, Testes | X | Mesothelioma Malignant, Metastatic, | | Testes | X | Sarcoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Pharynx | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + +| Glandular, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | Parenchyma, Carcinoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + +| C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | X | Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | Leukemia Mononuclear | | Bilateral, Adenoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Seminal Vesicle | + + + + M + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant, Metastatic, | | Testes | X | Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant | X X | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X | Interstitial Cell, Adenoma | X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + A| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + + M + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Basal Cell Carcinoma | X | Keratoacanthoma | | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant, Metastatic, | | Testes | X | Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant, Metastatic, | | Testes | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Malignant | X X | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| DAY ON TEST | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4| | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Rectum, Mesothelioma Malignant, | | Metastatic | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ileum, Jejunum, Mesothelioma | | Malignant, Metastatic, Testes | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Leukemia Mononuclear | X X X X X X X X | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Mesentery | + + + + + + + + + +| Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | | Sarcoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Glandular, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | Parenchyma, Carcinoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| DAY ON TEST | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4| | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | X X | Pheochromocytoma Benign | X X X X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | | Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X X| Carcinoma | | Leukemia Mononuclear | | Bilateral, Adenoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant, Metastatic, | | Testes | | Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| DAY ON TEST | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4| | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + M + + M M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Basal Cell Carcinoma | | Keratoacanthoma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| DAY ON TEST | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4| | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant, Metastatic, | | Testes | | Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant, Metastatic, | | Testes | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| | | | 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 60 | Rectum, Mesothelioma Malignant, | | | Metastatic | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 60 | Ileum, Jejunum, Mesothelioma | | | Malignant, Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 60 | Hepatocellular Carcinoma | | 1 | Leukemia Mononuclear | X X X X X X X X | 19 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + + | 22 | Mesothelioma Malignant, Multiple, | | | Metastatic, Testes | | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | Sarcoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach | + + + + + + + + M + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + | 59 | Glandular, Mesothelioma Malignant, | | | Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Tongue | + | 2 | Squamous Cell Papilloma | | 1 | Parenchyma, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| | | | 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 6 | Bilateral, Mesothelioma Malignant, | | | Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 6 | Pheochromocytoma Malignant | | 2 | Pheochromocytoma Benign | X X X | 12 | Bilateral, Pheochromocytoma Benign | X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + | 58 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 | C-Cell, Adenoma | X X X | 6 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 60 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | Bilateral, Mesothelioma Malignant, | | | Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 60 | Adenoma | X X X X X | 13 | Carcinoma | X X | 2 | Leukemia Mononuclear | X | 1 | Bilateral, Adenoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| | | | 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 58 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | Bilateral, Mesothelioma Malignant, | | | Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 60 | Bilateral, Mesothelioma Malignant | | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X | 49 | Interstitial Cell, Adenoma | X X X X | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 | Mediastinal, Leukemia Mononuclear | X X X | 4 | Pancreatic, Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 59 | Leukemia Mononuclear | X X X X | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X X X X X | 19 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + M + + + + + + | 53 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + + + + M + + + + + + | 56 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 60 | Basal Cell Adenoma | | 1 | Basal Cell Carcinoma | | 1 | Keratoacanthoma | | 1 | Subcutaneous Tissue, Sarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| | | | 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 9 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 4 | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + + + M + + + + + + + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 4 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | Bilateral, Mesothelioma Malignant, | | | Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X X X X X | 19 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4| DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8| | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| Ascending Colon, Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| Adenocarcinoma, Cystic, Mucinous | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + M + + + + + + + + + + + A + + + + + + + + + + +| Adenocarcinoma, Cystic, Mucinous | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X X X X X | Neoplastic Nodule | X X | __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| Adenocarcinoma, Multiple, Metastatic,| | Intestine Small | | Acinus, Adenoma | X | __________________________________________________________________________| Pharynx | + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + A + + + + + + + + + + +| Schwannoma Malignant | X X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + + + | Squamous Cell Carcinoma | X | Squamous Cell Papilloma | X X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4| DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8| | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Preputial Gland | + + + M + + + + + + + + + A + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X X | Bilateral, Adenoma | X X | Bilateral, Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + M + + + + + + + + + M + + + + + + + + + +| Adenocarcinoma, Multiple, Metastatic,| | Intestine Small | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + A + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Squamous Cell Carcinoma, Metastatic, | | Skin | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mediastinal, Pancreatic, | | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4| DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8| | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Adenocarcinoma, Metastatic, | | Intestine Small | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Thymus | + M M + + M M + + + + + M A + + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X X X X X| Basal Cell Adenoma, Multiple | X X X X X X X X X X | Basal Cell Carcinoma | X | Basal Cell Carcinoma, Multiple | X | Keratoacanthoma | X X X | Squamous Cell Carcinoma | X X X X | Squamous Cell Carcinoma, Multiple | | Squamous Cell Papilloma | X X X | Squamous Cell Papilloma, Multiple | X | Sebaceous Gland, Adenoma | X | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Neurofibroma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | +| Chordoma | | Cranium, Carcinoma, Metastatic, | | Zymbal's Gland | X| Cranium, Squamous Cell Carcinoma, | | Metastatic, Skin | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Cerebellum, Astrocytoma Malignant | | Cerebrum, Astrocytoma Malignant | | Meninges, Cerebrum, Perivascular, | | Squamous Cell Carcinoma, | | Metastatic, Skin | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + A + + + + + + + + + + +| Adenocarcinoma, Multiple, Metastatic,| | Intestine Small | | Basal Cell Carcinoma, Multiple, | | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4| DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8| | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Metastatic, Skin | | Carcinoma, Multiple, Metastatic, | | Zymbal's Gland | X| Carcinoma, Metastatic, Zymbal's Gland| X | Leukemia Mononuclear | X X X X X | Squamous Cell Carcinoma, Multiple, | | Metastatic, Skin | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + A + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Skin | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + +| Choroid, Conjunctiva, Retrobulbar, | | Squamous Cell Carcinoma, | | Metastatic, Skin | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X| Carcinoma | X X X X X X| Bilateral, Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +| Adenocarcinoma, Metastatic, | | Intestine Small | | Leukemia Mononuclear | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | | | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + A + + + + + | 43 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + A A + + + + + | 42 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + | 43 | Ascending Colon, Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + A A + + + + + | 42 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + A A + + + + + | 42 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + A A + + + + + | 42 | Adenocarcinoma, Cystic, Mucinous | X | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A A + + + + + | 42 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + A A + + + + + | 41 | Adenocarcinoma, Cystic, Mucinous | X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 45 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X | 16 | Neoplastic Nodule | X | 3 | __________________________________________________________________________|____________| Mesentery | + + + + + | 9 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 44 | Adenocarcinoma, Multiple, Metastatic,| | | Intestine Small | X | 1 | Acinus, Adenoma | X | 2 | __________________________________________________________________________|____________| Pharynx | + + + | 4 | Palate, Squamous Cell Papilloma | X X X | 4 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 44 | Schwannoma Malignant | | 2 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Tongue | | 4 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 44 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | | | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 44 | Leukemia Mononuclear | X X X | 6 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X X X X | 10 | Bilateral, Pheochromocytoma Benign | X X X X | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 44 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + | 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + | 43 | Leukemia Mononuclear | X | 2 | Pars Distalis, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 44 | C-Cell, Adenoma | X X X | 6 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 45 | Bilateral, Mesothelioma Malignant, | | | Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 43 | Adenoma | X | 4 | Carcinoma | X X | 5 | Bilateral, Adenoma | | 2 | Bilateral, Carcinoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + M + + + + + + + + + + | 42 | Adenocarcinoma, Multiple, Metastatic,| | | Intestine Small | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 45 | Bilateral, Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X | 35 | Interstitial Cell, Adenoma | X | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | | | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + | 43 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 43 | Mediastinal, Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 43 | Leukemia Mononuclear | X | 5 | Squamous Cell Carcinoma, Metastatic, | | | Skin | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + | 42 | Leukemia Mononuclear | | 3 | Mediastinal, Pancreatic, | | | Adenocarcinoma, Metastatic, | | | Intestine Small | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + A A + + + + + | 42 | Leukemia Mononuclear | X X X X X X X X | 16 | __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + M + M + + + + + M | 34 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 42 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 45 | Basal Cell Adenoma | X X X X X X X X X | 15 | Basal Cell Adenoma, Multiple | X X X X X X | 16 | Basal Cell Carcinoma | X X | 3 | Basal Cell Carcinoma, Multiple | | 1 | Keratoacanthoma | X X | 5 | Squamous Cell Carcinoma | X X X X | 8 | Squamous Cell Carcinoma, Multiple | X | 1 | Squamous Cell Papilloma | | 3 | Squamous Cell Papilloma, Multiple | X | 2 | Sebaceous Gland, Adenoma | X | 2 | Subcutaneous Tissue, Fibroma | X X | 4 | Subcutaneous Tissue, Neurofibroma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + | 3 | Chordoma | X | 1 | Cranium, Carcinoma, Metastatic, | | | Zymbal's Gland | | 1 | Cranium, Squamous Cell Carcinoma, | | | Metastatic, Skin | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | | | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + | 44 | Leukemia Mononuclear | | 1 | Cerebellum, Astrocytoma Malignant | X | 1 | Cerebrum, Astrocytoma Malignant | X | 1 | Meninges, Cerebrum, Perivascular, | | | Squamous Cell Carcinoma, | | | Metastatic, Skin | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 44 | Adenocarcinoma, Multiple, Metastatic,| | | Intestine Small | X | 1 | Basal Cell Carcinoma, Multiple, | | | Metastatic, Skin | X | 1 | Carcinoma, Multiple, Metastatic, | | | Zymbal's Gland | | 1 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | Leukemia Mononuclear | X X X X X | 10 | Squamous Cell Carcinoma, Multiple, | | | Metastatic, Skin | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 44 | Squamous Cell Carcinoma, Metastatic, | | | Skin | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + | 43 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 3 | Choroid, Conjunctiva, Retrobulbar, | | | Squamous Cell Carcinoma, | | | Metastatic, Skin | X | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 45 | Adenoma | | 3 | Carcinoma | X | 7 | Bilateral, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | | DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | | | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Adenocarcinoma, Metastatic, | | | Intestine Small | X | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 44 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 45 | Leukemia Mononuclear | X X X X X X X X X | 17 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4| DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2| | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Descending Colon, Adenocarcinoma | X | Descending Colon, Polyp Adenomatous | X X | Descending Colon, Polyp Adenomatous, | | Multiple | | __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + A + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + A + + + + + +| Adenocarcinoma | | Adenocarcinoma, Cystic, Mucinous | | Jejunum, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + A + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + A + + + + + +| Adenocarcinoma | | Adenocarcinoma, Cystic, Mucinous | X X X | __________________________________________________________________________| Liver | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Lymphoma Malignant Histiocytic | | Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Neoplastic Nodule | X X X | __________________________________________________________________________| Mesentery | + + + + + + + + + +| Mesothelioma Malignant, Multiple, | | Metastatic, Testes | X | Schwannoma Malignant | X| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Pharynx | | Palate, Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + A + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + A + + + + + + + + + + + + + + A + + + + + +| Leiomyosarcoma | X | Glandular, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4| DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2| | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | Schwannoma Benign | | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| Capsule, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Mesothelioma Malignant, Metastatic, | | Testes | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | X X X | __________________________________________________________________________| Preputial Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X X X X | Carcinoma | X X | Bilateral, Adenoma | | Bilateral, Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4| DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2| | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Seminal Vesicle | + + + M M + + + + + + + + M M + + M M M + + + + M| Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant | X X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Fibrous Histiocytoma, | | Metastatic, Skin | | Mediastinal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Lymphoma Malignant Histiocytic | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Thymus | + + + + + + M + M M + M + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Basal Cell Adenoma, Multiple | X X X X X X X X X X X X X | Basal Cell Carcinoma | X X X | Basal Cell Carcinoma, Multiple | X X | Keratoacanthoma | X X | Squamous Cell Carcinoma | X X X X X X | Squamous Cell Carcinoma, Multiple | X X X | Squamous Cell Papilloma | X X | Sebaceous Gland, Adenoma | X | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4| DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2| | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Sebaceous Gland, Carcinoma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Neurofibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | | __________________________________________________________________________| Skeletal Muscle | +| Abdominal, Schwannoma Malignant, | | Metastatic, Mesentery | X| Thoracic, Fibrous Histiocytoma, | | Metastatic, Skin | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | Cerebellum, Cerebrum, Astrocytoma | | Malignant | X | Cerebrum, Astrocytoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Carcinoma, Metastatic, Preputial | | Gland | | Carcinoma, Metastatic, Zymbal's Gland| | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X | Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Nose | + + + A + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Carcinoma | X X X X | Bilateral, Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4| DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2| | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Lymphoma Malignant Histiocytic | | Mesothelioma Malignant | X X X | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4| DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8| | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| Adenocarcinoma | X | Descending Colon, Adenocarcinoma | | Descending Colon, Polyp Adenomatous | X | Descending Colon, Polyp Adenomatous, | | Multiple | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + A + + A A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + + A A + + + + + + + + + + + +| Adenocarcinoma | X | Adenocarcinoma, Cystic, Mucinous | X | Jejunum, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + A A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + A A + + + + + + + + + + + +| Adenocarcinoma | X | Adenocarcinoma, Cystic, Mucinous | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Lymphoma Malignant Histiocytic | | Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Neoplastic Nodule | X | __________________________________________________________________________| Mesentery | + + + + + + + | Mesothelioma Malignant, Multiple, | | Metastatic, Testes | X | Schwannoma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Pharynx | + + | Palate, Squamous Cell Papilloma | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | Glandular, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4| DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8| | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | Schwannoma Benign | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Mesothelioma Malignant, Metastatic, | | Testes | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Carcinoma | X X X X X X X | Bilateral, Adenoma | X | Bilateral, Carcinoma | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4| DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8| | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Seminal Vesicle | + + + + M + + + M M + + + + + + + + + M + + + + +| Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Fibrous Histiocytoma, | | Metastatic, Skin | X | Mediastinal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Lymphoma Malignant Histiocytic | | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Thymus | + + M + + M + M + + + M M + + + + + + + + + + M M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + + + + + + + + + + + + + M + + M + + +| Fibroadenoma | X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X X X X X | Basal Cell Adenoma, Multiple | X X X X X X X X X X | Basal Cell Carcinoma | X X X X X | Basal Cell Carcinoma, Multiple | | Keratoacanthoma | X X X | Squamous Cell Carcinoma | X X X X X X | Squamous Cell Carcinoma, Multiple | X X X X | Squamous Cell Papilloma | X X | Sebaceous Gland, Adenoma | X | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4| DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8| | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Sebaceous Gland, Carcinoma | | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Fibrous | | Histiocytoma | X | Subcutaneous Tissue, Neurofibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | | __________________________________________________________________________| Skeletal Muscle | + | Abdominal, Schwannoma Malignant, | | Metastatic, Mesentery | | Thoracic, Fibrous Histiocytoma, | | Metastatic, Skin | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Cerebellum, Cerebrum, Astrocytoma | | Malignant | | Cerebrum, Astrocytoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Preputial | | Gland | X | Carcinoma, Metastatic, Zymbal's Gland| | Fibrous Histiocytoma, Metastatic, | | Skin | X | Leukemia Mononuclear | X X X | Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X X X X X X| Bilateral, Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4| DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8| | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant, Multiple, | | Metastatic, Testes | | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Lymphoma Malignant Histiocytic | | Mesothelioma Malignant | X X | _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| | DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| | | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 72 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 | Adenocarcinoma | | 2 | Descending Colon, Adenocarcinoma | X | 2 | Descending Colon, Polyp Adenomatous | | 3 | Descending Colon, Polyp Adenomatous, | | | Multiple | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 70 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 70 | Adenocarcinoma | | 1 | Adenocarcinoma, Cystic, Mucinous | | 1 | Jejunum, Mesothelioma Malignant, | | | Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 69 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 69 | Adenocarcinoma | | 1 | Adenocarcinoma, Cystic, Mucinous | X | 4 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | X X X X | 14 | Lymphoma Malignant Histiocytic | X | 1 | Mesothelioma Malignant, Multiple, | | | Metastatic, Testes | X | 1 | Neoplastic Nodule | X X X | 7 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + | 28 | Mesothelioma Malignant, Multiple, | | | Metastatic, Testes | X | 3 | Schwannoma Malignant | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Mesothelioma Malignant, Multiple, | | | Metastatic, Testes | X | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Pharynx | + + + + + | 7 | Palate, Squamous Cell Papilloma | X X X | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| | DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| | | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 | Leiomyosarcoma | | 1 | Glandular, Mesothelioma Malignant, | | | Metastatic, Testes | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 72 | __________________________________________________________________________|____________| Tongue | + + + + | 6 | Squamous Cell Papilloma | X X X X | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | Schwannoma Benign | X | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Capsule, Mesothelioma Malignant, | | | Metastatic, Testes | X | 2 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | | 2 | Pheochromocytoma Malignant | X | 3 | Pheochromocytoma Benign | X X X X | 16 | Bilateral, Pheochromocytoma Benign | X X X X | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | C-Cell, Adenoma | X | 5 | C-Cell, Carcinoma | X| 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| | DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| | | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Bilateral, Mesothelioma Malignant, | | | Metastatic, Testes | X X | 6 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 | Adenoma | X X X X X | 17 | Carcinoma | X X X | 12 | Bilateral, Adenoma | X | 2 | Bilateral, Carcinoma | X | 3 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Adenoma | X | 1 | Mesothelioma Malignant, Multiple, | | | Metastatic, Testes | X | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + M + + + + + + + + M M + + + + + + + + M M| 58 | Mesothelioma Malignant, Multiple, | | | Metastatic, Testes | X | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 2 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Bilateral, Mesothelioma Malignant | X X | 7 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X | 51 | Interstitial Cell, Adenoma | X X X X X X | 17 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Mediastinal, Fibrous Histiocytoma, | | | Metastatic, Skin | | 1 | Mediastinal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | X X X X X | 17 | Lymphoma Malignant Histiocytic | X | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| | DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| | | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + M + M M + + M M + + + + + + + M + M + + M + + +| 55 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + M + + + + + M + + + + + M + + + + + +| 68 | Fibroadenoma | | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Basal Cell Adenoma | X X X X X | 12 | Basal Cell Adenoma, Multiple | X X X X X X X X X X X X | 35 | Basal Cell Carcinoma | X X X X X X | 14 | Basal Cell Carcinoma, Multiple | X X | 4 | Keratoacanthoma | X X | 7 | Squamous Cell Carcinoma | X X X | 15 | Squamous Cell Carcinoma, Multiple | X X | 9 | Squamous Cell Papilloma | X X X | 7 | Sebaceous Gland, Adenoma | | 2 | Sebaceous Gland, Carcinoma | X | 1 | Subcutaneous Tissue, Fibroma | | 4 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | | 1 | Subcutaneous Tissue, Neurofibroma | X X| 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 3 | Abdominal, Schwannoma Malignant, | | | Metastatic, Mesentery | X | 2 | Thoracic, Fibrous Histiocytoma, | | | Metastatic, Skin | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Astrocytoma Malignant | | 1 | Cerebellum, Cerebrum, Astrocytoma | | | Malignant | | 1 | Cerebrum, Astrocytoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Alveolar/Bronchiolar Adenoma | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| | DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| | | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Carcinoma, Metastatic, Preputial | | | Gland | | 1 | Carcinoma, Metastatic, Zymbal's Gland| X | 1 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | Leukemia Mononuclear | X | 8 | Lymphoma Malignant Histiocytic | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Adenoma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + M | 3 | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Adenoma | X X X X X X | 11 | Carcinoma | X X | 13 | Bilateral, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 | Leukemia Mononuclear | X | 2 | Mesothelioma Malignant, Multiple, | | | Metastatic, Testes | X | 1 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 | Leukemia Mononuclear | X X X X X | 17 | Lymphoma Malignant Histiocytic | X | 1 | Mesothelioma Malignant | X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + M + + + + + + +| Adenocarcinoma, Cystic, Mucinous | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + A + + + + + + +| Descending Colon, Adenocarcinoma | X | Descending Colon, Polyp Adenomatous | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + A + + + + + + +| Adenocarcinoma | X | Polyp Adenomatous | | __________________________________________________________________________| Intestine Small | + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + M + A + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + M + + + + + + +| Adenocarcinoma | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + M + + + + + + +| Adenocarcinoma | X | Adenocarcinoma, Cystic, Mucinous | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | | Mesothelioma Malignant, Metastatic, | | Testes | X | Neoplastic Nodule | | Neoplastic Nodule, Multiple | | __________________________________________________________________________| Mesentery | + + + | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | X | Acinus, Adenoma | | __________________________________________________________________________| Pharynx | | Carcinoma, Metastatic, Zymbal's Gland| | Mucosa, Carcinoma, Metastatic, Skin | | Palate, Carcinoma, Metastatic, | | Zymbal's Gland | | Palate, Squamous Cell Carcinoma | | Palate, Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | Bilateral, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, Eye| | Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + +| C-Cell, Adenoma | | C-Cell, Carcinoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + M + + + + + + +| Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | X | __________________________________________________________________________| Preputial Gland | + + + + + + + M + + + + + + +| Adenoma | X X X | Carcinoma | X X X X X | Bilateral, Adenoma | | Bilateral, Carcinoma | X| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Seminal Vesicle | M + + M M + + + M + + + + + +| Adenoma | | __________________________________________________________________________| Testes | + + + + + + + M + + + + + + +| Mesothelioma Benign | X | Mesothelioma Malignant | X | Bilateral, Mesothelioma Benign | | Bilateral, Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + +| Axillary, Mediastinal, Basal Cell | | Carcinoma, Metastatic, Skin | | Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | | Inguinal, Carcinoma, Metastatic | X| Inguinal, Iliac, Carcinoma, | | Metastatic, Preputial Gland | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + +| Basal Cell Carcinoma, Metastatic, | | Skin | | Hemangiosarcoma | | Leukemia Mononuclear | X | Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Thymus | + + + M + + M + M + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + M + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X X X | Basal Cell Adenoma, Multiple | X X X X X | Basal Cell Carcinoma | X X | Basal Cell Carcinoma, Multiple | X X | Keratoacanthoma | | Squamous Cell Carcinoma | X X | Squamous Cell Carcinoma, Multiple | X X X | Squamous Cell Papilloma | | Squamous Cell Papilloma, Multiple | | Sebaceous Gland, Adenoma | | Sebaceous Gland, Carcinoma | | Subcutaneous Tissue, Carcinoma, | | Metastatic | X| Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibroma, | | Multiple | | Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Neurofibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + | Cranium, Carcinoma, Metastatic, | | Zymbal's Gland | X | Cranium, Squamous Cell Carcinoma, | | Metastatic | | __________________________________________________________________________| Skeletal Muscle | + | Cervical, Carcinoma, Metastatic, | | Zymbal's Gland | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + +| Cerebrum, Astrocytoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Basal Cell Carcinoma, Multiple, | | Metastatic, Skin | | Carcinoma, Multiple, Metastatic, | | Preputial Gland | X| Carcinoma, Multiple, Metastatic, | | Zymbal's Gland | X | Carcinoma, Metastatic, Zymbal's Gland| | Fibrosarcoma, Multiple, Metastatic, | | Skin | X | Squamous Cell Carcinoma, Multiple, | | Metastatic, Skin | | Squamous Cell Carcinoma, Metastatic, | | Skin | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + +| Submucosa, Schwannoma Malignant, | | Metastatic, Eye | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | Optic Nerve, Schwannoma Malignant | | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X X X| _____________________________________________________________________________________________________________________| Page 82 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4| DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Bilateral, Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | X | __________________________________________________________________________| Urethra | | __________________________________________________________________________| Urinary Bladder | + + + + + + + M + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Benign | X | Mesothelioma Malignant | X X | _____________________________________________________________________________________________________________________| Page 83 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4| DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4| | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| Adenocarcinoma, Cystic, Mucinous | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| Descending Colon, Adenocarcinoma | | Descending Colon, Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| Adenocarcinoma | | Polyp Adenomatous | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + A + + + + + + +| Adenocarcinoma | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + A + + + + + + +| Adenocarcinoma | | Adenocarcinoma, Cystic, Mucinous | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Leukemia Mononuclear | X X | Mesothelioma Malignant, Metastatic, | | Testes | | Neoplastic Nodule | X | Neoplastic Nodule, Multiple | X X | __________________________________________________________________________| Mesentery | + + + + + | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | | Acinus, Adenoma | X | __________________________________________________________________________| Pharynx | + + + | Carcinoma, Metastatic, Zymbal's Gland| | Mucosa, Carcinoma, Metastatic, Skin | | Palate, Carcinoma, Metastatic, | | Zymbal's Gland | | Palate, Squamous Cell Carcinoma | X | Palate, Squamous Cell Papilloma | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Tongue | + + + + + + | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| Page 84 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4| DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4| | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | X X X X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, Eye| X| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant, | | Metastatic, Testes | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X X X X X X | Bilateral, Adenoma | X | Bilateral, Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Seminal Vesicle | + + + + M + + + + M + + + + M + + + + + + + + + M| Adenoma | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Benign | | Mesothelioma Malignant | | Bilateral, Mesothelioma Benign | | Bilateral, Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 85 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4| DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4| | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Interstitial Cell, Adenoma | X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Mediastinal, Basal Cell | | Carcinoma, Metastatic, Skin | X | Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | X | Inguinal, Carcinoma, Metastatic | | Inguinal, Iliac, Carcinoma, | | Metastatic, Preputial Gland | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +| Basal Cell Carcinoma, Metastatic, | | Skin | X | Hemangiosarcoma | | Leukemia Mononuclear | X X X | Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Thymus | + + + + + + + + M M + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X X | Basal Cell Adenoma, Multiple | X X X X X X X X X X X X X | Basal Cell Carcinoma | X X X X | Basal Cell Carcinoma, Multiple | X | Keratoacanthoma | X | Squamous Cell Carcinoma | X X X X X X X X X| Squamous Cell Carcinoma, Multiple | X X | Squamous Cell Papilloma | X X| Squamous Cell Papilloma, Multiple | X | Sebaceous Gland, Adenoma | | Sebaceous Gland, Carcinoma | | Subcutaneous Tissue, Carcinoma, | | Metastatic | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibroma, | | Multiple | X | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| Page 86 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4| DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4| | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Neurofibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + | Cranium, Carcinoma, Metastatic, | | Zymbal's Gland | X | Cranium, Squamous Cell Carcinoma, | | Metastatic | X | __________________________________________________________________________| Skeletal Muscle | | Cervical, Carcinoma, Metastatic, | | Zymbal's Gland | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Astrocytoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Basal Cell Carcinoma, Multiple, | | Metastatic, Skin | X | Carcinoma, Multiple, Metastatic, | | Preputial Gland | | Carcinoma, Multiple, Metastatic, | | Zymbal's Gland | X | Carcinoma, Metastatic, Zymbal's Gland| | Fibrosarcoma, Multiple, Metastatic, | | Skin | | Squamous Cell Carcinoma, Multiple, | | Metastatic, Skin | X | Squamous Cell Carcinoma, Metastatic, | | Skin | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Submucosa, Schwannoma Malignant, | | Metastatic, Eye | X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | +| Optic Nerve, Schwannoma Malignant | X| __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X| Carcinoma | X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 87 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4| DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4| | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Bilateral, Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | | __________________________________________________________________________| Urethra | + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Testes | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Benign | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 88 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | | DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | | | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A | 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 58 | Adenocarcinoma, Cystic, Mucinous | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 58 | Descending Colon, Adenocarcinoma | X | 2 | Descending Colon, Polyp Adenomatous | X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 58 | Adenocarcinoma | | 1 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + | 55 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 57 | Adenocarcinoma | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + | 56 | Adenocarcinoma | | 1 | Adenocarcinoma, Cystic, Mucinous | X | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 60 | Hepatocellular Carcinoma | | 2 | Leukemia Mononuclear | | 2 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | Neoplastic Nodule | X X X | 4 | Neoplastic Nodule, Multiple | | 2 | __________________________________________________________________________|____________| Mesentery | + + + | 11 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | Acinus, Adenoma | | 1 | __________________________________________________________________________|____________| Pharynx | + + + + | 7 | Carcinoma, Metastatic, Zymbal's Gland| X | 1 | Mucosa, Carcinoma, Metastatic, Skin | X | 1 | Palate, Carcinoma, Metastatic, | | | Zymbal's Gland | X | 1 | Palate, Squamous Cell Carcinoma | | 1 | Palate, Squamous Cell Papilloma | X | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 89 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | | DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | | | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A | 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Tongue | + + + | 10 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | X | 7 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 | Pheochromocytoma Benign | | 5 | Bilateral, Pheochromocytoma Benign | X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 59 | Schwannoma Malignant, Metastatic, Eye| | 1 | Pars Distalis, Adenoma | X X | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 | C-Cell, Adenoma | | 1 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 59 | Bilateral, Mesothelioma Malignant, | | | Metastatic, Testes | X X | 3 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 59 | Adenoma | X X X X X | 11 | Carcinoma | X X X X X | 17 | Bilateral, Adenoma | | 1 | Bilateral, Carcinoma | | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 90 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | | DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | | | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A | 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + M M + + + M M + + + + M + M M + M | 44 | Adenoma | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 59 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 1 | Bilateral, Mesothelioma Benign | X | 1 | Bilateral, Mesothelioma Malignant | X X | 3 | Bilateral, Interstitial Cell, Adenoma| X X X X X | 24 | Interstitial Cell, Adenoma | X X X X X X X X X | 18 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 58 | Axillary, Mediastinal, Basal Cell | | | Carcinoma, Metastatic, Skin | | 1 | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | | 1 | Inguinal, Carcinoma, Metastatic | | 1 | Inguinal, Iliac, Carcinoma, | | | Metastatic, Preputial Gland | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 56 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 59 | Basal Cell Carcinoma, Metastatic, | | | Skin | | 1 | Hemangiosarcoma | X | 1 | Leukemia Mononuclear | | 4 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Thymus | M + M + + M + + + M M + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + M + + + + + + M + + + + + | 56 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 60 | Basal Cell Adenoma | X X X | 10 | Basal Cell Adenoma, Multiple | X X X X X X X | 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 91 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | | DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | | | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A | 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Basal Cell Carcinoma | X X X X X X X | 13 | Basal Cell Carcinoma, Multiple | X | 4 | Keratoacanthoma | | 1 | Squamous Cell Carcinoma | X X X X | 15 | Squamous Cell Carcinoma, Multiple | X | 6 | Squamous Cell Papilloma | X | 3 | Squamous Cell Papilloma, Multiple | X | 2 | Sebaceous Gland, Adenoma | X | 1 | Sebaceous Gland, Carcinoma | X | 1 | Subcutaneous Tissue, Carcinoma, | | | Metastatic | | 1 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Fibroma, | | | Multiple | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Neurofibroma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + | 6 | Cranium, Carcinoma, Metastatic, | | | Zymbal's Gland | X X X | 5 | Cranium, Squamous Cell Carcinoma, | | | Metastatic | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Cervical, Carcinoma, Metastatic, | | | Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 60 | Cerebrum, Astrocytoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 1 | Basal Cell Carcinoma, Multiple, | | | Metastatic, Skin | | 1 | Carcinoma, Multiple, Metastatic, | | | Preputial Gland | | 1 | Carcinoma, Multiple, Metastatic, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 92 NTP Experiment-Test: 05172-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97 Route: DOSED WATER Time: 17:32:19 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | | DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | | | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A | 330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Zymbal's Gland | | 2 | Carcinoma, Metastatic, Zymbal's Gland| X | 1 | Fibrosarcoma, Multiple, Metastatic, | | | Skin | | 1 | Squamous Cell Carcinoma, Multiple, | | | Metastatic, Skin | | 1 | Squamous Cell Carcinoma, Metastatic, | | | Skin | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 60 | Submucosa, Schwannoma Malignant, | | | Metastatic, Eye | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + | 2 | __________________________________________________________________________|____________| Eye | | 2 | Optic Nerve, Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 60 | Adenoma | X X | 9 | Carcinoma | X X X X X X X | 20 | Bilateral, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 60 | Mesothelioma Malignant, Metastatic, | | | Testes | | 1 | __________________________________________________________________________|____________| Urethra | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 59 | Mesothelioma Malignant, Metastatic, | | | Testes | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | Mesothelioma Benign | X | 2 | Mesothelioma Malignant | X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 93 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 886851-886851/886851 --multipart-boundary--