TDMS Study 05172-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: HLA, VA DATE: 09/18/94
EXP: 05172 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE TIME: 06:47:03
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: 99989
CONT: NO1ES9565503 CAS: 20325400
PATHOLOGIST: B. ULLAND
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: HLA, VA DATE: 09/18/94
EXP: 05172 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE TIME: 06:47:03
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: 99989
CONT: NO1ES9565503 CAS: 20325400
PATHOLOGIST: B. ULLAND
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 647 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 73 452 505 529 531 573 581 603 603 616 |
| 629 640 644 645 645 646 |
| CENSORED DEATHS |
| 275 275 275 275 275 275 275 275 275 275 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 80 PPM |
| --------------------- |
| |
| TOTAL 45 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 262 353 354 480 480 483 485 515 538 546 |
| 552 556 556 558 578 585 588 593 595 596 |
| 596 602 603 603 604 606 609 610 611 618 |
| 618 618 618 638 641 644 644 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 170 PPM |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 75 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 284 304 333 339 358 391 391 408 417 420 |
| 424 424 437 458 467 472 472 476 483 483 |
| 483 485 485 485 485 486 486 506 508 514 |
| 525 526 531 533 535 536 538 539 541 546 |
| 546 546 553 555 556 556 556 556 557 560 |
| 560 561 561 561 561 561 562 562 562 578 |
| 578 581 591 594 596 603 604 616 616 616 |
| 616 632 634 641 644 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 647 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 330 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 60 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 267 284 304 332 337 339 344 401 401 402 |
| 414 419 423 423 423 424 425 441 445 476 |
| 477 478 483 483 483 485 485 486 486 490 |
| 506 511 512 521 525 527 534 536 537 541 |
| 542 542 546 546 550 550 550 551 560 560 |
| 560 560 560 560 561 585 590 592 595 597 |
| CENSORED DEATHS |
| 275 275 275 275 275 275 275 275 275 275 |
| |
==================================================================================
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 647 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 647 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.6 98.6 98.6 98.6 98.6 96.9 91.9 85.2 73.5 73.5 |
| | |
| | |
|80 PPM | 100.0 100.0 97.8 93.3 93.3 84.4 80.0 44.4 17.8 17.8 |
| | |
| | |
|170 PPM | 100.0 100.0 100.0 93.3 84.0 66.7 48.0 10.7 0.0 0.0 |
| | |
| | |
|330 PPM | 100.0 100.0 98.6 88.5 71.8 55.1 30.1 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 80 PPM 170 PPM 330 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 73.5% 17.8% 0.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 557.2 560.4 517.9 484.5 |
|NATURAL DEATHS (C) | (35.4) (14.1) ( 9.3) (10.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 573.3 575.8 517.9 454.5 |
|(STANDARD ERROR) | (17.2) (12.6) ( 9.3) (12.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 648 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 402 528 532 543 574 578 590 599 600 602 |
| 618 624 624 631 644 |
| CENSORED DEATHS |
| 275 275 275 275 275 275 275 275 275 275 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 80 PPM |
| --------------------- |
| |
| TOTAL 45 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 373 424 424 436 476 483 485 485 505 512 |
| 520 562 564 571 573 588 599 599 602 606 |
| 616 616 616 618 618 618 618 618 632 644 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 170 PPM |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 69 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 220 274 287 287 304 304 309 331 333 339 |
| 339 339 344 354 358 358 358 361 373 378 |
| 378 379 379 408 408 408 419 423 424 424 |
| 436 436 436 449 450 450 465 468 476 476 |
| 477 483 483 483 483 486 501 505 506 527 |
| 533 550 550 550 550 556 561 562 562 563 |
| 563 564 571 583 597 602 616 616 641 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 648 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 330 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 60 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 251 262 270 284 287 304 304 317 339 339 |
| 344 344 344 344 344 354 358 363 378 378 |
| 395 402 408 408 408 423 424 424 424 424 |
| 430 431 431 431 431 436 436 441 450 452 |
| 452 465 483 483 483 483 485 485 491 548 |
| 560 560 561 563 563 596 602 610 613 613 |
| CENSORED DEATHS |
| 275 275 275 275 275 275 275 275 275 275 |
| |
==================================================================================
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 648 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 648 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.3 98.3 93.3 83.3 75.0 75.0 |
| | |
| | |
|80 PPM | 100.0 100.0 100.0 100.0 93.3 82.2 75.6 57.8 33.3 33.3 |
| | |
| | |
|170 PPM | 100.0 100.0 98.7 76.0 60.0 40.0 32.0 12.0 8.0 8.0 |
| | |
| | |
|330 PPM | 100.0 100.0 95.7 70.5 50.4 20.2 18.5 5.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 80 PPM 170 PPM 330 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 75.0% 33.3% 8.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 579.3 553.4 448.8 428.6 |
|NATURAL DEATHS (C) | (15.7) (13.7) (12.0) (12.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 580.0 584.9 464.7 406.7 |
|(STANDARD ERROR) | (15.7) (11.3) (12.7) (12.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
80 PPM = 2
170 PPM = 3
330 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 24 3
| 1 24 3 3 3 2 1 1
| 4 33 3 1 1
| 44 23 3 2 1 1
90 + 44 3 33 1 1
| 4 4 33 22 1 1
| 3 3 2 2 1 1
| 4 4 3 33 2 2 1 1 1
80 + 44 3 3 2 2
| 22 1 1
| 33 22
| 4 4 33 1
P 70 + 44 2 2
E | 4 44 22
R | 3 3
C | 33 22
E 60 + 33
N | 44 33 22
T | 33
|
S 50 + 4 4 3 3 22
U | 44
R | 44 33
V | 44 33
I 40 + 44 2 2
V |
A | 4 4 22
L | 33
30 +
| 44 2 2
|
| 3 3
20 + 44
| 3 3 2 2
| 33
| 33
10 + 44 3 3
| 4 44
| 3 3
| 44 33
0 + 4 3
|
---+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+--
0 10 20 30 40 50 60 70 80 90 100
WEEK
NOTE: 15 obs hidden.
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
80 PPM = 2
170 PPM = 3
330 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 3 4 2 1
| 3 4 4433 2 1 2 1
| 4 3 3 1 1
| 4 33 2 2 1 1 1
90 + 434 3 2 22 1 1
| 4 33 22 11
| 33
| 333 2 2 1 11
80 + 22
| 22 111
| 443 3 2 2 1 1
| 33
P 70 + 4 43 3 22
E | 4 4 2 2
R | 4 4333 2 2
C |
E 60 + 4 3 3
N | 22
T | 3 3 2 2
| 3 3
S 50 + 44 3 3 22
U | 33
R |
V | 4 4
I 40 + 33
V | 4 4 3 3 3 2 2
A | 3 3 22
L | 4 4 33 3 2 2
30 + 4 4
| 33
| 33
| 44
20 + 44
| 4 4433
| 3 3 3
| 44 3 3
10 + 3 3
| 4 4 3 3
| 4 4
|
0 + 4
|
---+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+--
0 10 20 30 40 50 60 70 80 90 100
WEEK
NOTE: 25 obs hidden.
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