TDMS Study 05180-06 Pathology Tables
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
2 YEAR CHRONIC RATS
Facility: Battelle Northwest
Chemical CAS #: 1303-00-0000
Lock Date: 03/13/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 30 30 23 35
Natural Death 1 3 6 4
Survivors
Terminal Sacrifice 19 17 20 11
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (48) (49)
Intestine Large, Rectum (50) (49) (49) (49)
Carcinoma 1 (2%)
Intestine Large, Cecum (50) (49) (48) (49)
Intestine Small, Duodenum (50) (48) (48) (49)
Leiomyoma 1 (2%)
Intestine Small, Jejunum (50) (48) (46) (49)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (50) (49) (46) (49)
Liver (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (6) (14) (6) (11)
Oral Mucosa (1) (2)
Gingival, Squamous Cell Carcinoma 1 (50%)
Pharyngeal, Squamous Cell Carcinoma 1 (50%)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (49)
Salivary Glands (50) (49) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Stomach, Glandular (50) (50) (50) (49)
Tongue (1) (2)
Squamous Cell Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Adrenal Medulla (50) (49) (50) (49)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 4 (8%) 5 (10%) 4 (8%) 8 (16%)
Bilateral, Pheochromocytoma Benign 2 (4%) 5 (10%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 1 (2%) 2 (4%)
Carcinoma 1 (2%)
Pituitary Gland (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Pars Distalis, Adenoma 42 (84%) 43 (86%) 36 (72%) 31 (63%)
Thyroid Gland (50) (49) (48) (49)
C-Cell, Adenoma 7 (14%) 4 (8%) 4 (8%) 1 (2%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Follicular Cell, Adenoma 2 (4%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (48) (47) (48)
Adenoma 7 (14%) 9 (19%) 7 (15%) 4 (8%)
Carcinoma 3 (6%) 2 (4%) 2 (4%) 2 (4%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (50) (50) (49)
Granulosa Cell Tumor Malignant 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (50) (49) (50)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 7 (14%) 6 (12%) 6 (12%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (49)
Lymph Node (3) (6) (3) (5)
Pancreatic, Histiocytic Sarcoma 1 (33%)
Lymph Node, Bronchial (36) (36) (39) (40)
Histiocytic Sarcoma 1 (3%) 1 (3%)
Lymph Node, Mandibular (43) (45) (45) (47)
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (34) (39) (39) (39)
Histiocytic Sarcoma 1 (3%) 1 (3%)
Spleen (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Thymus (45) (48) (41) (45)
Histiocytic Sarcoma 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 8 (16%) 2 (4%) 7 (14%) 4 (8%)
Carcinoma, Multiple 1 (2%) 1 (2%)
Fibroadenoma 21 (42%) 24 (48%) 18 (36%) 23 (46%)
Fibroadenoma, Multiple 5 (10%) 7 (14%) 11 (22%) 8 (16%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Rhabdomyosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Meningioma Malignant, Metastatic, Brain 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Meningioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 7 (14%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 3 (6%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (50) (50) (49) (49)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50) (49)
Leiomyoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Leukemia Mononuclear 22 (44%) 21 (42%) 18 (36%) 33 (66%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 49 49 47
Total Primary Neoplasms 136 132 135 148
Total Animals with Benign Neoplasms 48 46 43 43
Total Benign Neoplasms 101 98 96 97
Total Animals with Malignant Neoplasms 28 28 32 38
Total Malignant Neoplasms 35 34 39 51
Total Animals with Metastatic Neoplasms 1 1 1
Total Metastatic Neoplasm 1 1 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 30 29 32 33
Natural Death 7 8 3 4
Survivors
Terminal Sacrifice 13 13 15 13
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Intestine Large, Colon (47) (47) (48) (50)
Intestine Large, Rectum (48) (49) (47) (49)
Intestine Large, Cecum (46) (43) (48) (49)
Intestine Small, Duodenum (48) (48) (49) (50)
Intestine Small, Jejunum (45) (43) (48) (50)
Intestine Small, Ileum (44) (43) (48) (49)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (50) (50)
Cholangioma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (5) (10) (14) (7)
Carcinoma, Metastatic, Uncertain Primary Site 1 (14%)
Oral Mucosa (1) (3) (1)
Gingival, Squamous Cell Papilloma 1 (100%)
Pharyngeal, Squamous Cell Papilloma 3 (100%)
Pancreas (49) (49) (50) (50)
Adenoma 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (49) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (49) (50) (50)
Tongue (2) (2) (1)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (50%) 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (4) (6) (6)
Hemangiosarcoma 1 (17%)
Heart (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (49) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (50) (49) (49) (50)
Pheochromocytoma Malignant 2 (4%) 3 (6%) 1 (2%)
Pheochromocytoma Benign 12 (24%) 9 (18%) 17 (35%) 10 (20%)
Bilateral, Pheochromocytoma Benign 4 (8%) 3 (6%) 5 (10%) 3 (6%)
Islets, Pancreatic (48) (49) (50) (50)
Adenoma 2 (4%) 1 (2%) 2 (4%) 2 (4%)
Carcinoma 3 (6%) 1 (2%)
Pituitary Gland (49) (49) (50) (50)
Pars Distalis, Adenoma 21 (43%) 22 (45%) 21 (42%) 19 (38%)
Thyroid Gland (46) (46) (49) (50)
C-Cell, Adenoma 3 (7%) 5 (11%) 6 (12%) 2 (4%)
C-Cell, Carcinoma 3 (7%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (49) (50) (49)
Adenoma 2 (4%) 3 (6%) 6 (12%)
Carcinoma 4 (8%) 4 (8%) 5 (10%) 4 (8%)
Prostate (50) (48) (50) (50)
Adenoma 2 (4%)
Histiocytic Sarcoma 1 (2%)
Seminal Vesicle (45) (47) (48) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 42 (84%) 35 (70%) 37 (74%) 33 (66%)
Interstitial Cell, Adenoma 3 (6%) 5 (10%) 9 (18%) 8 (16%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (48) (50) (50)
Lymph Node (12) (8) (9) (5)
Schwannoma Malignant, Metastatic, Heart 1 (8%)
Inguinal, Fibrosarcoma, Metastatic, Skin 1 (13%)
Renal, Pheochromocytoma Malignant,
Metastatic, Adrenal Medulla 1 (8%)
Lymph Node, Bronchial (36) (37) (35) (42)
Plasma Cell Tumor Malignant 1 (3%)
Lymph Node, Mandibular (46) (43) (46) (44)
Lymph Node, Mesenteric (48) (48) (50) (48)
Lymph Node, Mediastinal (42) (40) (46) (47)
Plasma Cell Tumor Malignant 1 (2%)
Spleen (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma 1 (2%)
Thymus (46) (45) (45) (42)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (41) (42) (42) (40)
Carcinoma 1 (3%)
Fibroadenoma 2 (5%) 3 (7%) 2 (5%)
Skin (50) (49) (50) (50)
Basal Cell Adenoma 1 (2%) 1 (2%)
Keratoacanthoma 3 (6%) 2 (4%) 4 (8%) 3 (6%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 2 (4%) 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiopericytoma 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 2 (4%)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Hemangioma 1 (2%)
Oligodendroglioma Malignant 1 (2%) 1 (2%)
Sarcoma 1 (2%)
Peripheral Nerve (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Lung (50) (49) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 3 (6%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 2 (4%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 2 (4%)
Plasma Cell Tumor Malignant, Metastatic,
Lymph Node, Mediastinal 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Mediastinum, Sarcoma 1 (2%)
Nose (50) (48) (49) (50)
Pleura (1)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Renal Tubule, Adenoma 1 (2%) 3 (6%)
Renal Tubule, Adenoma, Multiple 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
Urinary Bladder (48) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Papilloma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 19 (38%) 28 (56%) 33 (66%) 28 (56%)
Mesothelioma Benign 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Mesothelioma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:15:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 50 48
Total Primary Neoplasms 139 142 173 149
Total Animals with Benign Neoplasms 50 47 49 46
Total Benign Neoplasms 103 98 119 107
Total Animals with Malignant Neoplasms 30 38 41 34
Total Malignant Neoplasms 36 44 54 42
Total Animals with Metastatic Neoplasms 3 4 1 1
Total Metastatic Neoplasm 5 6 4 1
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------