TDMS Study 05180-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest GALLIUM ARSENIDE DATE: 02/17/99
EXPERIMENT: 05180 TEST: 06 TIME: 08:22:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 62033B
PATHOLOGIST: GRUMBEIN, S. CAS: 1303-00-0000
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest GALLIUM ARSENIDE DATE: 02/17/99
EXPERIMENT: 05180 TEST: 06 TIME: 08:22:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 62033B
PATHOLOGIST: GRUMBEIN, S. CAS: 1303-00-0000
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 338 506 534 534 544 545 566 566 567 567 |
| 590 590 599 612 612 617 621 621 636 642 |
| 645 647 658 662 662 671 677 681 684 685 |
| 685 688 693 713 720 726 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 204 306 350 393 524 532 534 548 548 566 |
| 567 574 586 587 590 590 594 600 601 614 |
| 621 621 625 642 647 647 647 655 660 684 |
| 691 699 701 708 709 712 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 394 443 450 513 560 562 566 590 590 601 |
| 601 604 615 617 621 627 627 642 642 654 |
| 660 660 662 671 674 674 678 680 698 698 |
| 702 702 704 720 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 310 422 422 519 520 523 533 539 540 547 |
| 557 590 594 601 602 604 605 614 615 618 |
| 621 621 631 633 642 645 645 668 668 678 |
| 700 702 702 702 713 715 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 98.0 88.0 74.0 50.0 26.0 |
| | |
| | |
|0.01 | 100.0 100.0 98.0 94.0 92.0 92.0 86.0 62.0 42.0 26.0 |
|MG/M3 | |
| | |
|0.1 | 100.0 100.0 100.0 100.0 98.0 94.0 92.0 76.0 54.0 30.0 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 100.0 98.0 94.0 94.0 82.0 66.0 46.0 26.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.01 0.1 1.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 26.0% 26.0% 30.0% 26.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.803 P=0.782 P=0.725N P=0.838 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 622.5 589.1 623.5 602.5 |
|NATURAL DEATHS (C) | (12.7) (18.8) (13.3) (14.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 651.2 626.5 656.4 636.4 |
|(STANDARD ERROR) | (11.6) (16.5) (11.7) (13.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 302 310 497 506 581 582 588 589 590 604 |
| 607 621 621 642 649 660 660 660 677 678 |
| 679 684 685 688 699 702 703 716 716 730 |
| 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 310 422 478 497 509 523 548 559 563 585 |
| 590 590 606 613 621 628 631 649 660 685 |
| 687 688 688 695 700 702 702 713 714 723 |
| 726 726 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 198 310 339 354 448 462 534 534 547 603 |
| 604 605 609 630 631 639 646 646 647 660 |
| 668 674 674 674 678 679 684 701 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 39 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 215 254 310 418 422 476 478 506 519 534 |
| 554 556 564 564 590 594 605 631 631 632 |
| 632 674 674 677 677 684 685 688 691 691 |
| 696 702 703 704 709 712 712 716 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 96.0 96.0 96.0 92.0 80.0 64.0 38.0 |
| | |
| | |
|0.01 | 100.0 100.0 100.0 98.0 96.0 94.0 88.0 76.0 62.0 34.0 |
|MG/M3 | |
| | |
|0.1 | 100.0 100.0 98.0 92.0 92.0 88.0 84.0 76.0 60.0 42.0 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 96.0 94.0 90.0 86.0 80.0 66.0 58.0 22.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.01 0.1 1.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 38.0% 34.0% 42.0% 22.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.052 P=0.788 P=1.000 P=0.088 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 624.4 620.0 579.3 595.1 |
|NATURAL DEATHS (C) | (18.6) (17.3) (24.7) (20.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 666.0 658.8 644.3 625.7 |
|(STANDARD ERROR) | (13.8) (13.7) (17.9) (18.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GALLIUM ARSENIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.01 MG/M3 = 2
0.1 MG/M3 = 3
1.0 MG/M3 = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
104 +
|
| 1 2 4 1 3
| 2 2 4 1 3 4 3 1
96 + 2 2 3 3 1 1
| 2 2 4 3 3 4
| 2 3 2 11 3
| 22 33
88 + 4221 1
| 2 2 3 3
| 44
| 42 2 33
P 80 + 441 1
E | 422 433
R | 2 2 1133
C | 41 13
E 72 + 2 2
N | 44113
T |
| 2244 3 3
S 64 + 1 1
U | 2 24 11 3
R | 22 113 3
V |
I 56 + 224 11
V | 2 2 1 13
A | 422 33
L | 44 11
48 + 11
| 22 411
| 2 2 3 3
| 2442
40 + 42233
| 1124
| 22
| 1 213
32 + 4113
| 411 3
| 221 1
| 2 1
24 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.
GALLIUM ARSENIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.01 MG/M3 = 2
0.1 MG/M3 = 3
1.0 MG/M3 = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 4 1 2
| 3 4 4 1 1 2
| 4 1 3 3 42 2 1 1
| 3 44 3 2 1 1
90 + 4 3 3 4 2 2 11
| 3 44 2 3 2
| 4 4 4 3 222 1 1
| 4 4 3 2 2 1 1
P 80 + 4 4 2 2
E | 1 1
R | 44 2 2213 1
C | 4 4 223311
E 70 + 22331 1
N | 4 4 2233
T | 4 2 2 1 1
| 3 2 2
S 60 + 33 22
U | 4 311
R | 112
V | 11
I 50 + 44 11
V | 33
A | 34 1213
L | 212 1
40 + 44
| 44 1
| 2 2
| 44
30 +
|
| 44 4
| 4
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 36 obs hidden.