TDMS Study 05180-07 Pathology Tables
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
2 YEAR CHRONIC MICE
Facility: Battelle Northwest
Chemical CAS #: 1303-00-0000
Lock Date: 04/11/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 4|
| 6| 6| 9| 3| 9| 5| 3| 5| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 4| 5| 9| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus, Multiple | |
Degeneration, Fatty | |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | 1 |
Inflammation | 1 2 |
Necrosis | 1 1 |
Pigmentation, Hemosiderin | 2 |
Bile Duct, Cyst | |
Bile Duct, Degeneration, Hyaline | |
Oval Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
Fat, Necrosis | 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cytoplasmic Alteration | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 4|
| 6| 6| 9| 3| 9| 5| 3| 5| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 4| 5| 9| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 1 |
Hypertrophy | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + M + M + M + + + + + + + + M + + + + + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 4 1 1 3 4 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + M + M + + + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 3 2 |
Cyst | 2 3 1 3 2 1 1 3|
Interstitial Stromal Tumor | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hematocyst | X |
Hydrometra | 2 2 |
Hyperplasia, Cystic | |
Endometrium, Hyperplasia | |
Myometrium, Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Angiectasis | 4 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + M + + + + + M + + + + + + M|
Hyperplasia | 1 2 2 1 1 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + M + + M M + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + + + + + + + + + + + M M + + + + + + M M +|
Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 4|
| 6| 6| 9| 3| 9| 5| 3| 5| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 4| 5| 9| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 2 2 2 2 2 3 2 2|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 4 |
Capsule, Inflammation | |
__________________________________________________________________________|
Thymus | M + + + M + M + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 1 2 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1 1 |
__________________________________________________________________________|
Spinal Cord | + |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1|
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic, Focal | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 4|
| 6| 6| 9| 3| 9| 5| 3| 5| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 4| 5| 9| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Hydronephrosis | 1 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| |
| 6| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 5| 6| 9| 5| 9| 6| 7| 5| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + + A + + + + A + + + + + + + +| 47 |
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + A + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + + + + + + + + +| 48 |
Peyer's Patch, Hyperplasia | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A + + + + + + + + + + + + +| 48 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus, Multiple | X | 1 |
Degeneration, Fatty | 1 | 1 1.0|
Eosinophilic Focus | X X | 3 |
Eosinophilic Focus, Multiple | X X | 2 |
Hematopoietic Cell Proliferation | 1 | 3 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation | 1 | 3 1.3|
Necrosis | 1 | 3 1.0|
Pigmentation, Hemosiderin | | 1 2.0|
Bile Duct, Cyst | 3 | 1 3.0|
Bile Duct, Degeneration, Hyaline | 2 | 1 2.0|
Oval Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 | 5 1.2|
Cytoplasmic Alteration | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 1.0|
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| |
| 6| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 5| 6| 9| 5| 9| 6| 7| 5| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hypertrophy | 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M + + + + + M + M| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | M + M + + + + + I + + + + + + + + + + + + + + + +| 46 |
Pars Distalis, Hyperplasia | 2 2 1 2 2 4 1 2 2 | 16 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 2 1 1| 10 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M M M + + + + + + + + M + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Ovary | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 2 2.5|
Atrophy | 3 | 3 2.7|
Cyst | 2 2 2 2 4 2 1 1 1 2 | 18 1.9|
Interstitial Stromal Tumor | | 1 |
__________________________________________________________________________|____________|
Uterus | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 4.0|
Hematocyst | | 1 |
Hydrometra | | 2 2.0|
Hyperplasia, Cystic | 3 2 | 2 2.5|
Endometrium, Hyperplasia | 4 | 1 4.0|
Myometrium, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| |
| 6| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 5| 6| 9| 5| 9| 6| 7| 5| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M + + + + + M + + M M M + + + + + + + M +| 39 |
Hyperplasia | 1 2 1 1| 10 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + M + M + + + + M M M + + + + + M M + + M| 35 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + M + + + + + + + + + + + M M + + + + + + +| 40 |
Hyperplasia | 1 | 5 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 3 2 | 23 2.1|
Hyperplasia, Lymphoid | 2 2 2 2 2 4 2 2 2 2 2| 20 2.2|
Capsule, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + M + M + + + + + + + + + + + +| 43 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 1 2 1 1 1 2 1 1| 21 1.2|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | | 2 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 2 1.5|
Squamous Epithelium, Hyperplasia | 2 1 1 | 11 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| |
| 6| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 5| 6| 9| 5| 9| 6| 7| 5| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | 2 | 1 2.0|
Hemorrhage | 1 1 1 | 9 1.0|
Infiltration Cellular, Histiocyte | 1 3| 2 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 2 1.5|
Olfactory Epithelium, Atrophy | 1 1 | 3 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 | 3 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 1 1 1 1 | 15 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glomerulosclerosis | 4 2 | 2 3.0|
Hydronephrosis | | 1 1.0|
Metaplasia, Osseous | 1 | 2 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 43 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + A + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 5| 3| 8| 4| 3| 2| 3| 1| 3| 3| 3| 3| 3|
| 6| 6| 6| 7| 6| 5| 5| 6| 6| 6| 7| 5| 9| 6| 8| 4| 5| 4| 5| 5| 5| 6| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + A + + + + + + +|
Degeneration, Hyaline | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + A + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + A + + + + + + +|
Hemorrhage | 2 |
Inflammation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X |
Eosinophilic Focus, Multiple | X X |
Hematopoietic Cell Proliferation | 3 1 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
Inflammation | |
Necrosis | 1 1 |
Oval Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 2 1 |
Cytoplasmic Alteration | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
Epithelium, Hyperplasia | 2 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1|
Artery, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 5| 3| 8| 4| 3| 2| 3| 1| 3| 3| 3| 3| 3|
| 6| 6| 6| 7| 6| 5| 5| 6| 6| 6| 7| 5| 9| 6| 8| 4| 5| 4| 5| 5| 5| 6| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hypertrophy | 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
Pars Distalis, Hyperplasia | 2 4 1 3 2 4 1 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + M + + M + + + + + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 3 2 3 2 2 1 2 3 1 2 1 4 |
Hyperplasia | |
Germinal Epithelium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | 3 4 |
Hyperplasia, Cystic | 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + |
Angiectasis | 3 |
Renal, Angiectasis | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + M + + M + + + + + + +|
Hyperplasia | 1 1 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M M + + + + M + + + + M + + + + M + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + M + + + + + + M + M + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 5| 3| 8| 4| 3| 2| 3| 1| 3| 3| 3| 3| 3|
| 6| 6| 6| 7| 6| 5| 5| 6| 6| 6| 7| 5| 9| 6| 8| 4| 5| 4| 5| 5| 5| 6| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 3 2 2 2|
Hyperplasia, Lymphoid | 2 2 3 1 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | 1 |
Subcutaneous Tissue, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 1 2 3 1 1 2 1 1 1 3 2 |
Maxilla, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 2 2 2 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1|
Infiltration Cellular, Histiocyte | 1 2 1 2 1 1 2 1 1 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Foreign Body | X X X X X X |
Alveolus, Proteinosis | 1 1 1 1 |
Mediastinum, Necrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 2 2 2 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 5| 3| 8| 4| 3| 2| 3| 1| 3| 3| 3| 3| 3|
| 6| 6| 6| 7| 6| 5| 5| 6| 6| 6| 7| 5| 9| 6| 8| 4| 5| 4| 5| 5| 5| 6| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy | 2 1 1 1 1 1 1 1 1 1 3 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 7| 0| 3| 3| 5| 1| 0| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 9| 7| 5| 6| 2| 7| 3| 7| 9| 5| 1| 7| 5| 9| 2| 6| 6| 6| 7| 7| 7| 5| 7| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + + + A A + + + + + + + + + +| 45 |
Degeneration, Hyaline | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Hemorrhage | | 1 2.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 4 | 1 4.0|
Eosinophilic Focus | X X X X X X X X | 13 |
Eosinophilic Focus, Multiple | | 2 |
Hematopoietic Cell Proliferation | 1 1 | 4 1.5|
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | 3 | 3 2.3|
Inflammation | 2 | 1 2.0|
Necrosis | 1 1| 4 1.0|
Oval Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Necrosis | 2 2 2 3 2 | 9 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 4| 10 1.6|
Cytoplasmic Alteration | 1 | 1 1.0|
Duct, Cyst | 4| 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | 1 2 | 6 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 | 2 1.5|
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 7| 0| 3| 3| 5| 1| 0| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 9| 7| 5| 6| 2| 7| 3| 7| 9| 5| 1| 7| 5| 9| 2| 6| 6| 6| 7| 7| 7| 5| 7| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 2 1 2 1 1 1 1 1 1| 48 1.1|
Artery, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hypertrophy | 1 | 5 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M + + + M + M + + M + + + + + M + + + +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Pars Distalis, Hyperplasia | 2 2 1 2 3 2 1 2 1 1 1| 20 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 3 1 4 1 1 1 2| 17 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + M M + + + + + + + + + + + + + + + M +| 42 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 | 2 3.0|
Cyst | 2 1 2 2 2 | 17 2.1|
Hyperplasia | 4 | 1 4.0|
Germinal Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hydrometra | 3 2 | 4 3.0|
Hyperplasia, Cystic | 2 | 2 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Angiectasis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 7| 0| 3| 3| 5| 1| 0| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 9| 7| 5| 6| 2| 7| 3| 7| 9| 5| 1| 7| 5| 9| 2| 6| 6| 6| 7| 7| 7| 5| 7| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Angiectasis | 2 | 1 2.0|
Renal, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + M + + + + + + + + + + + + M + + M + + +| 43 |
Hyperplasia | 1 2 1 1 2 1 1| 12 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + M + + + I + + + M + + + + + + + M| 37 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hyperplasia | 4 | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + M + + + + M + + + + + + + + + +| 43 |
Hyperplasia | 3 | 3 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2| 22 2.1|
Hyperplasia, Lymphoid | 2 2 2 2 2 | 12 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 | 4 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Hemorrhage | 4 | 2 2.5|
Subcutaneous Tissue, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 1 1 2 1 2 1 1 2 1| 24 1.5|
Maxilla, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 5 1.6|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 2 1.5|
Squamous Epithelium, Hyperplasia | 2 1 1 | 9 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 7| 0| 3| 3| 5| 1| 0| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 9| 7| 5| 6| 2| 7| 3| 7| 9| 5| 1| 7| 5| 9| 2| 6| 6| 6| 7| 7| 7| 5| 7| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 6 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 13 1.2|
Inflammation, Chronic, Focal | 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 1 1 1 1| 5 1.0|
Alveolus, Foreign Body | X X | 8 |
Alveolus, Proteinosis | | 4 1.0|
Mediastinum, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 1 1 1 1 1| 17 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | 1 1 | 3 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + M + + + + + M| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 2| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 4| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 8| 1| 0| 3| 8| 3|
| 5| 4| 6| 6| 3| 6| 6| 7| 3| 9| 6| 0| 6| 5| 7| 6| 7| 9| 6| 3| 1| 9| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + A + + M + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X |
Eosinophilic Focus, Multiple | X |
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia, Lymphoid | 1 |
Inflammation | |
Necrosis | 2 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Inflammation, Suppurative | 3 |
Fat, Necrosis | 4 2 3 2 2 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 4 1 1 2 2 |
Cytoplasmic Alteration | 1 |
Hyperplasia, Lymphoid | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hypertrophy | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 2| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 4| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 8| 1| 0| 3| 8| 3|
| 5| 4| 6| 6| 3| 6| 6| 7| 3| 9| 6| 0| 6| 5| 7| 6| 7| 9| 6| 3| 1| 9| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + M + + + M + + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 1 3 3 1 4 2 1 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | |
Cyst | 1 4 2 1 1 1 1 2 2 1 1 2 3 2 1 1|
Hemorrhage | |
Thrombosis | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 4 4 |
Hyperplasia, Cystic | |
Inflammation, Suppurative | 2 |
Myometrium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + M + M + M + + + + + + + + + M +|
Hyperplasia | 1 1 1 1 3 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + M + + + M + + + + + + + + + +|
Hyperplasia | 4|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 2 3 2 2 2 2 2 2 3 |
Hyperplasia, Lymphoid | 2 2 2 2 4 2 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 2| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 4| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 8| 1| 0| 3| 8| 3|
| 5| 4| 6| 6| 3| 6| 6| 7| 3| 9| 6| 0| 6| 5| 7| 6| 7| 9| 6| 3| 1| 9| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + + + + + + + + + + M|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | 2 |
Subcutaneous Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 1 2 |
Maxilla, Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1 |
__________________________________________________________________________|
Spinal Cord | + |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Squamous Epithelium, Hyperplasia | 1 2 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 2 2 2 3 3 2 2 1 1 2 1 2 3 2 2 2 4 2 2 2 2 4 2|
Inflammation, Chronic, Focal | 2 2 1 1 2 1 |
Inflammation, Focal, Suppurative | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 1 |
Alveolus, Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X|
Alveolus, Proteinosis | 2 3 2 3 2 2 4 3 2 2 1 4 4 3 3 3 3 2 2 2 2 3 1 3|
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 1 |
Olfactory Epithelium, Atrophy | 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 3 1 1 |
Olfactory Epithelium, Inflammation, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 2| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 4| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 8| 1| 0| 3| 8| 3|
| 5| 4| 6| 6| 3| 6| 6| 7| 3| 9| 6| 0| 6| 5| 7| 6| 7| 9| 6| 3| 1| 9| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic | |
Olfactory Epithelium, Metaplasia, | |
Respiratory | 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 2 1 1 2 3 3 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 4| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| |
DAY ON TEST | 3| 6| 5| 1| 2| 3| 3| 3| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 8| 3| 3| |
| 5| 5| 9| 5| 1| 5| 6| 6| 6| 5| 5| 7| 7| 5| 6| 5| 6| 5| 5| 3| 6| 9| 1| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mast Cell | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 3 | 1 3.0|
Peyer's Patch, Hyperplasia | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 1 |
Degeneration, Fatty | 3 | 1 3.0|
Eosinophilic Focus | X X X X X | 10 |
Eosinophilic Focus, Multiple | | 1 |
Hematopoietic Cell Proliferation | 1 2 1 | 5 1.2|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation | 2 | 1 2.0|
Necrosis | 1 2 2 | 7 1.6|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 16 |
Inflammation, Suppurative | 4 | 2 3.5|
Fat, Necrosis | 3 4 2 2 4 | 13 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 1 | 11 1.5|
Cytoplasmic Alteration | 1 | 2 1.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Duct, Cyst | 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 47 1.0|
Artery, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 4| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| |
DAY ON TEST | 3| 6| 5| 1| 2| 3| 3| 3| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 8| 3| 3| |
| 5| 5| 9| 5| 1| 5| 6| 6| 6| 5| 5| 7| 7| 5| 6| 5| 6| 5| 5| 3| 6| 9| 1| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hypertrophy | 1 1 1 1| 7 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + I + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 1 1 1 2 2 2 2 1 1 | 20 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 2| 14 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M M + + + M + + + M + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Atrophy | 4 3 | 2 3.5|
Cyst | 4 2 2 1 2 3 3 | 23 1.9|
Hemorrhage | 2 | 1 2.0|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 | 2 2.5|
Hydrometra | 4 | 3 4.0|
Hyperplasia, Cystic | 4 3 | 2 3.5|
Inflammation, Suppurative | | 1 2.0|
Myometrium, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
Angiectasis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + M + + M + + + + + + + + + + +| 42 |
Hyperplasia | 1 1 1 1 1 2 1 | 13 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 4| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| |
DAY ON TEST | 3| 6| 5| 1| 2| 3| 3| 3| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 8| 3| 3| |
| 5| 5| 9| 5| 1| 5| 6| 6| 6| 5| 5| 7| 7| 5| 6| 5| 6| 5| 5| 3| 6| 9| 1| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + M + + + + + + + + + + + + + + M + +| 43 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 4 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 1 | 2 2.0|
Hyperplasia | 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 4 2 2 2 2 2 2 2 | 22 2.4|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 | 18 2.1|
__________________________________________________________________________|____________|
Thymus | + + M + I M + + + + + + + M + + + + + + + + + + +| 43 |
Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Hemorrhage | 3 | 2 2.5|
Subcutaneous Tissue, Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 2 2 1 1 1 1 1 1 | 14 1.4|
Maxilla, Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 4| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| |
DAY ON TEST | 3| 6| 5| 1| 2| 3| 3| 3| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 8| 3| 3| |
| 5| 5| 9| 5| 1| 5| 6| 6| 6| 5| 5| 7| 7| 5| 6| 5| 6| 5| 5| 3| 6| 9| 1| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 1 1 1 1 | 5 1.0|
Infiltration Cellular, Histiocyte | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2| 48 2.0|
Inflammation, Chronic, Focal | 2 1 1 1 2 | 11 1.5|
Inflammation, Focal, Suppurative | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 | 27 1.1|
Alveolus, Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X| 48 |
Alveolus, Proteinosis | 3 2 1 2 1 2 3 3 3 2 1 2 3 3 4 2 3 3 3 2 3 2 2 3 3| 49 2.5|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 4 1.3|
Olfactory Epithelium, Atrophy | 1 2 1 2 | 7 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 2 | 10 1.3|
Olfactory Epithelium, Inflammation, | | |
Chronic | 2 | 1 2.0|
Olfactory Epithelium, Metaplasia, | | |
Respiratory | | 1 2.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 1 1 1 | 21 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Degeneration | 4 | 1 4.0|
Cornea, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Artery, Inflammation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 4| 7| 3| 7| 7| 6| 7| 7| 5| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 0| 9| 3| 6| 3| 3| 7| 3| 3| 2| 8| 6| 1| 5| 3| 2| 3| 3| 3| 3| 3|
| 7| 7| 6| 8| 5| 7| 7| 5| 6| 5| 3| 5| 7| 9| 2| 4| 0| 9| 7| 9| 7| 7| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + A A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A A A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A A + + A + M + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X |
Hematopoietic Cell Proliferation | 2 1 2 1 |
Necrosis | 2 1 1 1 |
Serosa, Inflammation | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | 2 |
Inflammation, Chronic | |
Fat, Necrosis | 2 4 2 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Atrophy | 1 2 |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Ulcer | 1 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1|
Artery, Inflammation | 2 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hypertrophy | 1 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 4| 7| 3| 7| 7| 6| 7| 7| 5| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 0| 9| 3| 6| 3| 3| 7| 3| 3| 2| 8| 6| 1| 5| 3| 2| 3| 3| 3| 3| 3|
| 7| 7| 6| 8| 5| 7| 7| 5| 6| 5| 3| 5| 7| 9| 2| 4| 0| 9| 7| 9| 7| 7| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + + + + + + M + + + M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + I + + + + +|
Pars Distalis, Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 1 1 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + M + + + + M M + + + + + + + + M + +|
__________________________________________________________________________|
Ovary | I + + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | 3 2 1 1 2 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Hyperplasia, Cystic | 4 |
Thrombosis | |
Myometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M M + + + + M + A + + + + + + + + + +|
Hyperplasia | 2 2 1 2 2 2 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + M M + + + M + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + M + + + +|
Hyperplasia | 4 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M A + + + + + + M + + +|
Hyperplasia | 1 2 2 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 2 2 2 2 4 3 2 2|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + A + M + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 4| 7| 3| 7| 7| 6| 7| 7| 5| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 0| 9| 3| 6| 3| 3| 7| 3| 3| 2| 8| 6| 1| 5| 3| 2| 3| 3| 3| 3| 3|
| 7| 7| 6| 8| 5| 7| 7| 5| 6| 5| 3| 5| 7| 9| 2| 4| 0| 9| 7| 9| 7| 7| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 2 1 1 1 2 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hemorrhage | |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 4 1 |
Infiltration Cellular, Histiocyte | 2 3 3 2 2 2 3 1 3 2 2 2 3 2 1 2 2 2 2 3 3 2 2 3|
Inflammation, Chronic, Focal | 1 1 1 1 1 2 1 |
Inflammation, Focal, Suppurative | 2 2 2 3 2 3 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 2 2 2 1 1 1 2 2 2 2 1 2 2 1 1 1|
Alveolus, Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X|
Alveolus, Proteinosis | 4 2 2 2 3 2 3 2 3 2 2 3 4 3 3 3 3 2 2 2 2 3 1 4 2|
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 |
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 |
Olfactory Epithelium, Metaplasia, | |
Respiratory | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 3 1 1 1 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + M + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cornea, Inflammation, Chronic | 4|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 4| 7| 3| 7| 7| 6| 7| 7| 5| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 0| 9| 3| 6| 3| 3| 7| 3| 3| 2| 8| 6| 1| 5| 3| 2| 3| 3| 3| 3| 3|
| 7| 7| 6| 8| 5| 7| 7| 5| 6| 5| 3| 5| 7| 9| 2| 4| 0| 9| 7| 9| 7| 7| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Capsule, Inflammation | 2 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| |
DAY ON TEST | 3| 1| 3| 2| 0| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 1| 3| 4| 3| 9| 3| |
| 5| 2| 6| 2| 7| 6| 7| 7| 6| 6| 5| 7| 6| 2| 6| 5| 5| 6| 5| 4| 6| 6| 7| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + M + + A + + A + + M + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + A + + A + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| 45 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Degeneration, Fatty | | 1 2.0|
Eosinophilic Focus | X X X X X X| 10 |
Eosinophilic Focus, Multiple | X X X | 4 |
Hematopoietic Cell Proliferation | 1 | 5 1.4|
Necrosis | 2 | 5 1.4|
Serosa, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 13 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | 4 2 2 2 2 2 | 11 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 2 1.5|
Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | | 2 1.0|
Epithelium, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 47 1.1|
Artery, Inflammation | | 1 2.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypertrophy | 1 1 1 1 1| 7 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| |
DAY ON TEST | 3| 1| 3| 2| 0| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 1| 3| 4| 3| 9| 3| |
| 5| 2| 6| 2| 7| 6| 7| 7| 6| 6| 5| 7| 6| 2| 6| 5| 5| 6| 5| 4| 6| 6| 7| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + + M + + M M M M M M M M M + + + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 1 2 3 4 1 | 9 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + I + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 1 2 4 1 | 12 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + M + + + M + +| 42 |
__________________________________________________________________________|____________|
Ovary | + + + I + + + + + + + + + + + + + + + I + + + + +| 46 |
Cyst | 1 2 1 2 1 3 1 | 15 1.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 4 2 2 | 4 2.8|
Hyperplasia, Cystic | 2 3 | 3 3.0|
Thrombosis | 4 | 1 4.0|
Myometrium, Hyperplasia | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 6 |
Renal, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + M M + M +| 42 |
Hyperplasia | 1 4 1 2 1 3 1 1 4 1 3 1 2 1 1| 23 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + M + + M + + + +| 43 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Hyperplasia | 2 2 | 6 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia | 3 1 1 | 8 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2| 28 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| |
DAY ON TEST | 3| 1| 3| 2| 0| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 1| 3| 4| 3| 9| 3| |
| 5| 2| 6| 2| 7| 6| 7| 7| 6| 6| 5| 7| 6| 2| 6| 5| 5| 6| 5| 4| 6| 6| 7| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 4 2 | 7 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + M M + + + + + + + + + + +| 44 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 1 1 2 2 1 1 3 1| 18 1.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Hemorrhage | 2 | 1 2.0|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Squamous Epithelium, Hyperplasia | 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 | 5 1.6|
Infiltration Cellular, Histiocyte | 2 1 3 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 2 3 2 2 3 2 2| 49 2.2|
Inflammation, Chronic, Focal | 1 1 2 1 2 2 1 2 1 2 2| 18 1.4|
Inflammation, Focal, Suppurative | 2 2 2 3 2 1 1| 14 2.0|
Alveolar Epithelium, Hyperplasia | 1 2 1 1 2 1 1 2 2 2 1 1 1 1 1 1 1 1 1 1 2 1| 43 1.3|
Alveolus, Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X X| 49 |
Alveolus, Proteinosis | 3 1 2 2 3 1 3 4 2 1 4 3 4 2 2 2 3 2 3 2 4 3 4 1 1| 50 2.5|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| |
DAY ON TEST | 3| 1| 3| 2| 0| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 1| 3| 4| 3| 9| 3| |
| 5| 2| 6| 2| 7| 6| 7| 7| 6| 6| 5| 7| 6| 2| 6| 5| 5| 6| 5| 4| 6| 6| 7| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 | 4 1.0|
Olfactory Epithelium, Atrophy | 2 1 1 | 4 1.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 | 5 1.2|
Olfactory Epithelium, Metaplasia, | | |
Respiratory | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 3 1 2 1 | 17 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + I + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1| 36 1.1|
Capsule, Inflammation | | 1 2.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 4| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 3| 5| 2| 4| 3| 3| 3| 3| 7|
| 9| 5| 4| 3| 5| 5| 5| 5| 3| 4| 3| 4| 4| 3| 4| 8| 5| 7| 7| 7| 5| 3| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A M + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A A + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + A + + + + + A|
Peyer's Patch, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + A + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X X X X |
Eosinophilic Focus, Multiple | X X |
Hematopoietic Cell Proliferation | 1 |
Inflammation | |
Necrosis | 1 1 4 3 4 |
Bile Duct, Cyst | 2 |
Oval Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 1 1 2 1 2 |
Inflammation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | 1 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Hypertrophy | 3 1 1 2 1 2 1 1 2 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 4| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 3| 5| 2| 4| 3| 3| 3| 3| 7|
| 9| 5| 4| 3| 5| 5| 5| 5| 3| 4| 3| 4| 4| 3| 4| 8| 5| 7| 7| 7| 5| 3| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M M + M M + + + + M + + M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 1 |
Inflammation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + M + + M + + + M M + + M + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + M + + + + + + M + + + M + M + + + M + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + M + + + + + M + + M + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 2 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + I + + + + M + + + + + + M + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 4| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 3| 5| 2| 4| 3| 3| 3| 3| 7|
| 9| 5| 4| 3| 5| 5| 5| 5| 3| 4| 3| 4| 4| 3| 4| 8| 5| 7| 7| 7| 5| 3| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Prepuce, Inflammation, Chronic Active| |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 |
Squamous Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 2 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolus, Proteinosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydronephrosis | 2 |
Inflammation, Chronic Active | |
Nephropathy | 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 2 1 2 1 1 1|
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 4| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 7| 3| 5| 2| 4| 3| 3| 3| 3| 7|
| 9| 5| 4| 3| 5| 5| 5| 5| 3| 4| 3| 4| 4| 3| 4| 8| 5| 7| 7| 7| 5| 3| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| 8| 3| 3| 3| 0| 3| 6| 3| 3| 3| 0| 3| 3| 7| 6| |
| 3| 3| 3| 5| 3| 3| 2| 5| 3| 9| 6| 4| 3| 3| 2| 4| 1| 4| 4| 4| 7| 3| 4| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + M + + + + + + + + + + M + + A +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + A + + + + + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + A + + M + + + + + + + + + + A +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + A + + + + + + + + + + + + + A +| 44 |
Peyer's Patch, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + A + + + + + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | | 1 2.0|
Eosinophilic Focus | X X X | 8 |
Eosinophilic Focus, Multiple | X | 3 |
Hematopoietic Cell Proliferation | 1 1 | 3 1.0|
Inflammation | 1 3 | 2 2.0|
Necrosis | 1 3 2 1 3 | 10 2.3|
Bile Duct, Cyst | | 1 2.0|
Oval Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | A | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1| 13 1.5|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 1 | 2 1.5|
Epithelium, Hyperplasia | 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 2 1 1 1 1 1 1 1 2 2 1 2 1 2 1 1 1 1| 48 1.2|
Atrium, Thrombosis | 3 3| 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| 8| 3| 3| 3| 0| 3| 6| 3| 3| 3| 0| 3| 3| 7| 6| |
| 3| 3| 3| 5| 3| 3| 2| 5| 3| 9| 6| 4| 3| 3| 2| 4| 1| 4| 4| 4| 7| 3| 4| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 1 | 4 1.8|
Hypertrophy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 | 38 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + M + + M + + + + + M + + + + M + M + M| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 | 11 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 1 4.0|
Inflammation | 3 | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 | 5 2.2|
Inflammation | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1| 6 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + + M + M + + + + M M + + + + M + +| 38 |
Hyperplasia | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + M + + + M M + + + M + +| 37 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M M + M + + + + M + + + M + M M M| 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| 8| 3| 3| 3| 0| 3| 6| 3| 3| 3| 0| 3| 3| 7| 6| |
| 3| 3| 3| 5| 3| 3| 2| 5| 3| 9| 6| 4| 3| 3| 2| 4| 1| 4| 4| 4| 7| 3| 4| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 4 2 3 2 2 2| 17 2.2|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + M + M M + + + + + + M + + + M + + + M| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
Prepuce, Inflammation, Chronic Active| 4 4 | 2 4.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 1 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hemorrhage | 1 1 | 5 1.2|
Infiltration Cellular, Histiocyte | 4 1 4| 3 3.0|
Inflammation, Chronic, Focal | 1| 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 4 1.3|
Alveolus, Proteinosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 | 7 1.1|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 2 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| 8| 3| 3| 3| 0| 3| 6| 3| 3| 3| 0| 3| 3| 7| 6| |
| 3| 3| 3| 5| 3| 3| 2| 5| 3| 9| 6| 4| 3| 3| 2| 4| 1| 4| 4| 4| 7| 3| 4| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cornea, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + M M| 47 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Hydronephrosis | 2 | 2 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 2 1 1 1 3| 48 1.2|
Cortex, Cyst | 2 | 2 2.0|
Renal Tubule, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 4| 3| 4| 3| 3| 5| 5| 3| 9| 4| 3| 5| 4| 3| 4| 4| 3| 4| 5| 4| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
Degeneration, Hyaline | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X|
Hematopoietic Cell Proliferation | 1 |
Inflammation | 2 |
Necrosis | 1 3 4 3 1 |
Oval Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 4 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
__________________________________________________________________________|
Tooth | + + |
Malformation | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 2 2 2 1 1 1|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 1 |
Hypertrophy | 1 1 1 1 1 1 1 2 2 1 1 1 2 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 |
__________________________________________________________________________|
Parathyroid Gland | + + M + M M M + M M + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 4| 3| 4| 3| 3| 5| 5| 3| 9| 4| 3| 5| 4| 3| 4| 4| 3| 4| 5| 4| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 2 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 3 |
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 |
Inflammation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M M M M + + + + + + + + + + + + M + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + M + + + + M + + + + + + + + +|
Hyperplasia | 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Erythrophagocytosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + M M + + + + M + + + + + + M + M + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + M M M + M + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 4| 3| 4| 3| 3| 5| 5| 3| 9| 4| 3| 5| 4| 3| 4| 4| 3| 4| 5| 4| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 4 |
Subcutaneous Tissue, Inflammation, | |
Focal, Suppurative | 4 |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Squamous Epithelium, Hyperplasia | 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 1 |
Inflammation, Chronic, Focal | 1 |
Alveolar Epithelium, Hyperplasia | 4 1 1 1 1 4 1 |
Alveolus, Foreign Body | X X X X |
Alveolus, Proteinosis | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Olfactory Epithelium, Atrophy | 2 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 4| 3| 4| 3| 3| 5| 5| 3| 9| 4| 3| 5| 4| 3| 4| 4| 3| 4| 5| 4| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct | |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 2 2 1 1 2 1 2 1 1 2|
Capsule, Inflammation | |
Cortex, Cyst | 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 1| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 2| 3| 7| 8| 3| 3| 1| 3| 3| 3| |
| 5| 1| 5| 5| 0| 4| 3| 4| 5| 3| 4| 3| 9| 4| 4| 9| 4| 8| 1| 5| 3| 7| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Degeneration, Hyaline | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + A + + + + + + + + + + + + + + + + + + + M| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 2 |
Degeneration, Fatty | | 1 2.0|
Eosinophilic Focus | X X X X X X X X | 12 |
Eosinophilic Focus, Multiple | 1 | 2 1.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation | 2 2 | 3 2.0|
Necrosis | 2 | 6 2.3|
Oval Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Necrosis | 2 | 5 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 | 7 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 1 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Malformation | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 50 1.2|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 2 | 10 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 1| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 2| 3| 7| 8| 3| 3| 1| 3| 3| 3| |
| 5| 1| 5| 5| 0| 4| 3| 4| 5| 3| 4| 3| 9| 4| 4| 9| 4| 8| 1| 5| 3| 7| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | 1 2 2 2 1 2 2 1 1 1 2 1 1 1 1 2| 33 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + M + M M + + M + + + + + + + M + M + M +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 | 13 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 2 3.5|
Hyperplasia | 2| 1 2.0|
Inflammation | 2| 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Ectasia | 2 | 3 2.3|
Inflammation | 1 1| 3 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 3 1 4 | 9 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M M + + + + + M + + M + + M + + + M + +| 37 |
Hyperplasia | 1 1 2 1 2 1 | 7 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + M + + M M + + + + + + + + + M + M +| 40 |
Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Erythrophagocytosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | 2 2 2 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 1| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 2| 3| 7| 8| 3| 3| 1| 3| 3| 3| |
| 5| 1| 5| 5| 0| 4| 3| 4| 5| 3| 4| 3| 9| 4| 4| 9| 4| 8| 1| 5| 3| 7| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + M + + + + + + M + + M + + M + M M + + +| 36 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 2 2 3 2 2 2| 13 2.2|
Hyperplasia, Lymphoid | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + M + + M M + + + + + + M + M + + M M + + M| 36 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Chronic Active| 4 1 1 | 4 2.5|
Subcutaneous Tissue, Inflammation, | | |
Focal, Suppurative | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 | 13 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 | 6 1.0|
Infiltration Cellular, Histiocyte | 4 2 4 | 10 1.8|
Inflammation, Chronic, Focal | 2 4 | 3 2.3|
Alveolar Epithelium, Hyperplasia | 4 4 | 9 2.3|
Alveolus, Foreign Body | | 4 |
Alveolus, Proteinosis | 2 | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 3 1.7|
Olfactory Epithelium, Atrophy | | 2 2.0|
Olfactory Epithelium, Degeneration, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 1| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 2| 3| 7| 8| 3| 3| 1| 3| 3| 3| |
| 5| 1| 5| 5| 0| 4| 3| 4| 5| 3| 4| 3| 9| 4| 4| 9| 4| 8| 1| 5| 3| 7| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyaline | 1 1 | 4 1.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 2 1.5|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 2 2 | 3 2.0|
Infarct | 2 | 1 2.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1| 49 1.2|
Capsule, Inflammation | 1 | 1 1.0|
Cortex, Cyst | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 9| 5| 5| 5| 3| 3| 3| 4| 3| 3| 4| 4| 3| 4| 4| 3| 3| 4| 4| 5| 4| 5| 3| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X X X X X X X |
Eosinophilic Focus, Multiple | X X |
Hematopoietic Cell Proliferation | 1 |
Inflammation | |
Necrosis | 1 |
Bile Duct, Cyst | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 4 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Artery, Inflammation | 2 |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 4 |
Hypertrophy | 1 1 1 1 1 1 2 1 1 1 1 2 1 1 2 1 1 1 1 2 1|
Mineralization | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 9| 5| 5| 5| 3| 3| 3| 4| 3| 3| 4| 4| 3| 4| 4| 3| 3| 4| 4| 5| 4| 5| 3| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + M + + + + M M + + M M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 4|
Inflammation | 4 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + M + + + M + + + + M + + + +|
Hyperplasia | 2 2 2 2 2 2 2 1 1 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M M + + + + M + + M + M + + + M + M + M + M M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + M + M M M + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + M M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Prepuce, Inflammation, Chronic Active| 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 9| 5| 5| 5| 3| 3| 3| 4| 3| 3| 4| 4| 3| 4| 4| 3| 3| 4| 4| 5| 4| 5| 3| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 2 1 2|
Infiltration Cellular, Histiocyte | 2 2 2 4 1 2 2 2 2 2 2 2 1 2 1 4 1 2 2 2 2 2 2 2 2|
Inflammation, Chronic, Focal | 3 |
Inflammation, Focal, Suppurative | 2 2 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 4 2 1 1 2 2 2 2 4 1 2 2 2 1 2 2 2 2 2 1 1|
Alveolus, Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X|
Alveolus, Proteinosis | 3 2 2 2 1 3 2 1 3 3 2 2 3 3 3 2 3 3 3 3 3 2 1 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Olfactory Epithelium, Atrophy | 2 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 1 4 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 9| 5| 5| 5| 3| 3| 3| 4| 3| 3| 4| 4| 3| 4| 4| 3| 3| 4| 4| 5| 4| 5| 3| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Capsule, Inflammation | |
Renal Tubule, Hyperplasia | 1 1 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 5| 2| 6| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| |
DAY ON TEST | 7| 4| 3| 0| 3| 4| 3| 7| 3| 3| 3| 0| 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 8| 0| |
| 2| 8| 3| 4| 2| 5| 3| 3| 3| 4| 3| 9| 9| 3| 2| 4| 3| 3| 5| 4| 4| 3| 2| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A + + A + + M M M + + + + A + + + + + + + + A A| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + A + + A + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + A + + A + + + + + + A + + + + + + + + A A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + A + + A + + + + + + A + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + A + + A + + + + + + A + + + + + + + + + A| 45 |
Peyer's Patch, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + A + + A + + + + + + A + + + + + + + + + A| 45 |
Peyer's Patch, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Clear Cell Focus | | 2 |
Degeneration, Fatty | | 1 2.0|
Eosinophilic Focus | X X X | 11 |
Eosinophilic Focus, Multiple | X | 3 |
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Inflammation | 3 | 1 3.0|
Necrosis | 1 3 2 3 | 5 2.0|
Bile Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 1 1 1| 9 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 49 1.1|
Artery, Inflammation | | 1 2.0|
Ventricle, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 5| 2| 6| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| |
DAY ON TEST | 7| 4| 3| 0| 3| 4| 3| 7| 3| 3| 3| 0| 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 8| 0| |
| 2| 8| 3| 4| 2| 5| 3| 3| 3| 4| 3| 9| 9| 3| 2| 4| 3| 3| 5| 4| 4| 3| 2| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 3 1 | 7 2.4|
Hypertrophy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | 38 1.1|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + M M M M + M + + M + + + M M + + M + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + I + + + + I + + + + +| 47 |
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 2 4 | 7 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 2 4 | 5 3.0|
Inflammation | 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + A + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M + M + + + + M + + + M + + + + + + M +| 40 |
Hyperplasia | 1 1 1 3 1 | 17 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + + M M M + M + + + + + M + + M + M + + M +| 28 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 4 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + M + + + M + M + + M + + + + + + + M| 38 |
Hyperplasia | 2 2 1 2 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 5| 2| 6| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| |
DAY ON TEST | 7| 4| 3| 0| 3| 4| 3| 7| 3| 3| 3| 0| 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 8| 0| |
| 2| 8| 3| 4| 2| 5| 3| 3| 3| 4| 3| 9| 9| 3| 2| 4| 3| 3| 5| 4| 4| 3| 2| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 3 2 2 2 | 19 2.1|
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + M + M + + + M M + + + + M + + M + M M +| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Prepuce, Inflammation, Chronic Active| 3 4 | 3 3.7|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 | 1 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | 1 1 | 6 1.3|
Infiltration Cellular, Histiocyte | 2 2 1 1 1 2 1 2 2 2 2 1 2 2 2 2 2 2 1 2| 45 1.9|
Inflammation, Chronic, Focal | 2 1 | 3 2.0|
Inflammation, Focal, Suppurative | 2 2 2 2 | 8 1.8|
Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 2 1 2 2 1 2 1 1 1 | 39 1.6|
Alveolus, Foreign Body | X X X X X X X X X X X X X X X X X X X X X X| 46 |
Alveolus, Proteinosis | 3 2 3 2 2 1 2 2 2 3 2 3 2 1 3 2 2 3 3 3 3 2 2 2| 49 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1| 2 1.5|
Olfactory Epithelium, Atrophy | 1 1 | 5 1.2|
Olfactory Epithelium, Degeneration, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 5| 2| 6| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| |
DAY ON TEST | 7| 4| 3| 0| 3| 4| 3| 7| 3| 3| 3| 0| 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 0| 8| 0| |
| 2| 8| 3| 4| 2| 5| 3| 3| 3| 4| 3| 9| 9| 3| 2| 4| 3| 3| 5| 4| 4| 3| 2| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyaline | 1 1 | 6 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 4 | 10 1.9|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 1 | 2 1.5|
Inflammation, Chronic Active | 2 | 1 2.0|
Metaplasia, Osseous | 2 | 4 1.3|
Nephropathy | 1 1 3 1 1 2 1 2 1 1 1 1 2 1 1 1 1 1 1 1 | 45 1.2|
Capsule, Inflammation | 1 1 | 2 1.0|
Renal Tubule, Hyperplasia | 1 | 3 1.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + A + M + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 4| 3| 3| 3| 3| 3| 3| 2| 3| 0|
| 5| 1| 4| 1| 5| 3| 4| 3| 4| 3| 3| 3| 6| 3| 5| 5| 4| 3| 3| 4| 3| 3| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + M + + + + + + + + A|
Degeneration, Hyaline | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + A M + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + M + A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + M + A + + + + + + + + + A|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + A + A + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X |
Eosinophilic Focus, Multiple | X |
Hematopoietic Cell Proliferation | |
Necrosis | 2 1 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + A|
Degeneration, Cystic | 2 |
Hyperplasia | 2 |
Hypertrophy | 1 1 2 1 1 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + A|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + M + + + + + M + + M + + M M + M|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 4| 3| 3| 3| 3| 3| 3| 2| 3| 0|
| 5| 1| 4| 1| 5| 3| 4| 3| 4| 3| 3| 3| 6| 3| 5| 5| 4| 3| 3| 4| 3| 3| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Follicular Cell, Hyperplasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + A|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Ectasia | 3 |
Inflammation | 3 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + A + + + + + + + + + + A + + + + + + + + + + + A|
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + M M + + + + + + + M + + + A|
Hyperplasia | 2 2 1 1 2 1 2 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M M M + M + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + A|
Angiectasis | 1 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M M + + + + + M + + + + M + + + + M + + + A|
Hyperplasia | 2 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Thymus | + + + + M + + M + + + + M + + + + + + + M + M M A|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Prepuce, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 4| 3| 3| 3| 3| 3| 3| 2| 3| 0|
| 5| 1| 4| 1| 5| 3| 4| 3| 4| 3| 3| 3| 6| 3| 5| 5| 4| 3| 3| 4| 3| 3| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + A|
Squamous Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
Hyperplasia, Atypical | |
Infiltration Cellular, Histiocyte | 3 3 3 2 2 2 2 3 1 2 2 2 3 2 2 2 2 4 2 2 2 2 2 2 |
Inflammation, Chronic, Focal | 1 2 2 1 |
Inflammation, Focal, Suppurative | 3 1 2 2 1 2 2 3 1 2 1 3 1|
Alveolar Epithelium, Hyperplasia | 1 4 4 1 2 1 2 2 2 2 1 1 2 2 2 2 2 1 1 1 2 1 2 |
Alveolus, Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X X|
Alveolus, Proteinosis | 3 2 3 2 2 3 4 3 1 2 3 3 3 2 3 3 2 2 3 3 2 3 1 1 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Respiratory Epithelium, Degeneration,| |
Hyaline | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Degeneration | 4 4 |
__________________________________________________________________________|
Harderian Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hydronephrosis | 1 |
Inflammation, Chronic Active | |
Nephropathy | 2 1 2 1 1 1 1 1 1 1 1 2 1 1 1 3 1 1 1 1 1 2 1 |
Cortex, Cyst | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 4| 3| 3| 3| 3| 3| 3| 2| 3| 0|
| 5| 1| 4| 1| 5| 3| 4| 3| 4| 3| 3| 3| 6| 3| 5| 5| 4| 3| 3| 4| 3| 3| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 9| 5| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| |
| 4| 5| 4| 5| 4| 3| 2| 4| 9| 9| 4| 9| 5| 6| 4| 4| 4| 3| 4| 1| 3| 3| 5| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + A + A + + + + + + + + + + A| 43 |
Degeneration, Hyaline | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + A + A + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + A + A + + + + + + + + + + A| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + + A + A + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + A + A + + + + + + + + + + +| 43 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + A + A + + + + + + + + + + A| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X X X X | 14 |
Eosinophilic Focus, Multiple | X X X X | 5 |
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Necrosis | | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + A + A + + + + + + + + + + +| 47 |
Atrophy | 1 2 1 | 6 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Ulcer | | 1 3.0|
Epithelium, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 47 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 2 1 3 | 4 2.0|
Hypertrophy | 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | 30 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 9| 5| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| |
| 4| 5| 4| 5| 4| 3| 2| 4| 9| 9| 4| 9| 5| 6| 4| 4| 4| 3| 4| 1| 3| 3| 5| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + A + A + + + + + + + + + + +| 47 |
Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + M + M + + + + + + + + M M +| 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + A + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 1 2 1 1 | 8 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Ectasia | 2 2 2 3 | 5 2.4|
Inflammation | 3 1 2 2 3 2 | 9 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + A + + + + A + A + + + + + + + + + + A| 43 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + A M + + + + + + + + + + M +| 41 |
Hyperplasia | 2 2 1 2 1 1 3 2 2 3 1 1 1 1 | 24 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + M M + M + A M M M M + + + + + M + M +| 32 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + M +| 46 |
Angiectasis | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 3 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + M M + + M + A M + M M + + + + + + + + M| 33 |
Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 9| 5| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| |
| 4| 5| 4| 5| 4| 3| 2| 4| 9| 9| 4| 9| 5| 6| 4| 4| 4| 3| 4| 1| 3| 3| 5| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + A + A + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2| 18 2.0|
Hyperplasia, Lymphoid | 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + M + M + + + M + M + M + + + + + + M M + M +| 35 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
Prepuce, Inflammation, Chronic Active| 4 4 4 | 3 4.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Squamous Epithelium, Hyperplasia | 1 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hemorrhage | 1 1 | 3 1.0|
Hyperplasia, Atypical | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 2 3 2 2 2 3 2 2 3| 48 2.2|
Inflammation, Chronic, Focal | 2 1 2 3 1 2 2 2| 12 1.8|
Inflammation, Focal, Suppurative | 2 2 2 2 1 3 2 2 2 1 | 23 1.9|
Alveolar Epithelium, Hyperplasia | 2 2 1 2 2 2 2 1 1 2 2 2 2 3 1 2 2 2 2 2 2 2| 45 1.8|
Alveolus, Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X X| 50 |
Alveolus, Proteinosis | 2 4 1 3 3 3 2 2 2 2 3 2 1 2 2 1 2 1 2 2 3 3 2 3 3| 50 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 1 2 1 | 8 1.1|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 | 1 2.0|
Respiratory Epithelium, Degeneration,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:25:46
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| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 9| 5| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| |
| 4| 5| 4| 5| 4| 3| 2| 4| 9| 9| 4| 9| 5| 6| 4| 4| 4| 3| 4| 1| 3| 3| 5| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
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RESPIRATORY SYSTEM - cont | | |
| | |
Hyaline | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Degeneration | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Hydronephrosis | 2 1 | 3 1.3|
Inflammation, Chronic Active | 1 | 1 1.0|
Nephropathy | 1 1 1 1 2 1 1 1 1 3 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 47 1.2|
Cortex, Cyst | 2 1 | 2 1.5|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + A + A + + + + + + + + + + +| 46 |
Inflammation | 4 4 | 2 4.0|
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* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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