Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2012

TDMS Study 05181-04 Pathology Tables

NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09




       Facility:  Battelle Northwest

       Chemical CAS #:  0109-99-9

       Lock Date:  03/24/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3|             
                                           | 6| 6| 7| 4| 6| 9| 9| 9| 9| 9| 7| 6| 7| 0| 3| 4| 5| 6| 7| 6| 6| 7| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  M  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X                                                           X   |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |    X                          X           X                             X|             
      Hepatocellular Adenoma, Multiple     |                                     X                                    |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Hepatocholangiocarcinoma, Multiple   |                                        X                                 |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Histiocytic Sarcoma                  |                                                                          |             
      Sarcoma                              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  M  M  I  +  +  M  +  M  +  +  +  M  M  +  +  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                             X  X     X                    X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      Follicular Cell, Adenoma             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3|             
                                           | 6| 6| 7| 4| 6| 9| 9| 9| 9| 9| 7| 6| 7| 0| 3| 4| 5| 6| 7| 6| 6| 7| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deciduoma Benign                     |                                  X                                       |             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                      X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +           +   |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  M  +  M  M  +  M  +  +  +  +  M  +  M  +  +  +  M  M  M|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  +  +  +  +  +  M  M  +  M  +  +  +  +  M  +  +  +  M  +  +  +|             
      Hemangioma                           |                                                 X                        |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  M  +  +  A  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  M  M  M  M  M  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                      X   |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3|             
                                           | 6| 6| 7| 4| 6| 9| 9| 9| 9| 9| 7| 6| 7| 0| 3| 4| 5| 6| 7| 6| 6| 7| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Sarcoma                          |                                                                          |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Metastatic, Mesentery            |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                      X   |             
      Osteosarcoma                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Mediastinum, Lymphoma Malignant      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |       X                             X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 7| 5| 4| 7| 4| 5| 7| 7| 6| 7| 7| 4| 6| 7| 7|            |
                             DAY ON TEST   | 0| 3| 8| 3| 3| 0| 3| 3| 0| 5| 3| 7| 7| 3| 4| 7| 3| 3| 4| 3| 3| 4| 5| 3| 3|            |
                                           | 8| 7| 0| 3| 3| 4| 6| 3| 2| 1| 3| 4| 8| 3| 2| 2| 6| 3| 8| 4| 4| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                X                                         X               |          4 |
      Hepatocellular Carcinoma, Multiple   |                                     X                             X      |          2 |
      Hepatocellular Adenoma               |       X                    X  X                    X  X           X      |         10 |
      Hepatocellular Adenoma, Multiple     |                   X                                                      |          2 |
      Hepatocholangiocarcinoma             |                                                       X                  |          1 |
      Hepatocholangiocarcinoma, Multiple   |                                                                          |          1 |
      Histiocytic Sarcoma                  |       X                                   X  X                           |          3 |
      Lymphoma Malignant                   |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                                   +        +     +            |   6        |
      Histiocytic Sarcoma                  |                                              X                           |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Papilloma              |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +  M  I  M  +  +  +  +|  30        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 7| 5| 4| 7| 4| 5| 7| 7| 6| 7| 7| 4| 6| 7| 7|            |
                             DAY ON TEST   | 0| 3| 8| 3| 3| 0| 3| 3| 0| 5| 3| 7| 7| 3| 4| 7| 3| 3| 4| 3| 3| 4| 5| 3| 3|            |
                                           | 8| 7| 0| 3| 3| 4| 6| 3| 2| 1| 3| 4| 8| 3| 2| 2| 6| 3| 8| 4| 4| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  47        |
      Pars Distalis, Adenoma               | X  X              X        X           X                                 |         10 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |                                                             X            |          1 |
      Follicular Cell, Adenoma             |                   X                                                      |          2 |
      Follicular Cell, Carcinoma           |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Histiocytic Sarcoma                  |       X                                      X                           |          2 |
      Lymphoma Malignant                   |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Deciduoma Benign                     |                                                                          |          1 |
      Histiocytic Sarcoma                  |       X                                                                  |          1 |
      Polyp Stromal                        |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |       X                                   X                              |          2 |
      Lymphoma Malignant                   |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                 +           +                           |   5        |
      Renal, Histiocytic Sarcoma           |                                              X                           |          1 |
      Renal, Lymphoma Malignant            |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +|  36        |
      Histiocytic Sarcoma                  |       X                                                                  |          1 |
      Lymphoma Malignant                   |                         X     X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  40        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant                   |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Histiocytic Sarcoma                  |       X                                                                  |          1 |
      Lymphoma Malignant                   |                X        X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|  37        |
      Lymphoma Malignant                   |                         X     X                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 7| 5| 4| 7| 4| 5| 7| 7| 6| 7| 7| 4| 6| 7| 7|            |
                             DAY ON TEST   | 0| 3| 8| 3| 3| 0| 3| 3| 0| 5| 3| 7| 7| 3| 4| 7| 3| 3| 4| 3| 3| 4| 5| 3| 3|            |
                                           | 8| 7| 0| 3| 3| 4| 6| 3| 2| 1| 3| 4| 8| 3| 2| 2| 6| 3| 8| 4| 4| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant                   |                X        X                                            X   |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  M  +  M  +|  40        |
      Lymphoma Malignant                   |                         X     X                                         X|          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                           X                              |          1 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Metastatic, Mesentery            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                           X  X                           |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |          X                                                               |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                     X                                    |          1 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                       X                  |          1 |
      Histiocytic Sarcoma                  |       X                                   X  X                           |          3 |
      Lymphoma Malignant                   |                         X                                                |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 7| 5| 4| 7| 4| 5| 7| 7| 6| 7| 7| 4| 6| 7| 7|            |
                             DAY ON TEST   | 0| 3| 8| 3| 3| 0| 3| 3| 0| 5| 3| 7| 7| 3| 4| 7| 3| 3| 4| 3| 3| 4| 5| 3| 3|            |
                                           | 8| 7| 0| 3| 3| 4| 6| 3| 2| 1| 3| 4| 8| 3| 2| 2| 6| 3| 8| 4| 4| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +           +              +           +                              |   4        |
      Adenoma                              |    X           X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |       X                                   X  X                           |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |       X                                   X  X                           |          3 |
      Lymphoma Malignant                   |                X        X     X                                      X  X|          7 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 3| 0| 4| 6| 4| 0| 0| 6| 7| 4| 3| 4| 3| 7| 8| 0| 6| 4| 4| 4| 6| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                            X           X  X                              |             
      Hepatocellular Carcinoma, Multiple   |                                  X                                       |             
      Hepatocellular Adenoma               |          X           X  X     X     X        X        X        X         |             
      Hepatocellular Adenoma, Multiple     |                   X                       X                              |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +                    +     +                       +   |             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Hemangiosarcoma                      |                                        X                                 |             
      Lymphoma Malignant                   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Pheochromocytoma Benign              |                         X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  M  M  M  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 3| 0| 4| 6| 4| 0| 0| 6| 7| 4| 3| 4| 3| 7| 8| 0| 6| 4| 4| 4| 6| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X              X                                          |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                   X                                                      |             
      Polyp Stromal                        |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                               +               |             
      Inguinal, Lymphoma Malignant         |          X                                                               |             
      Pancreatic, Lymphoma Malignant       |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  M  +  M  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  I  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant                   |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  M  +  M  +  +  +  +  I  +  M  +  +  M  M  +  +  I  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 3| 0| 4| 6| 4| 0| 0| 6| 7| 4| 3| 4| 3| 7| 8| 0| 6| 4| 4| 4| 6| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                                        X                                 |             
      Lymphoma Malignant                   |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant                   |          X                                                           X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                          X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X  X                              |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
      Mediastinum,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Adenoma                              |                                                          X               |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 3| 0| 4| 6| 4| 0| 0| 6| 7| 4| 3| 4| 3| 7| 8| 0| 6| 4| 4| 4| 6| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |          X                                                           X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 4| 7| 5| 7| 7| 6|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 6| 3| 5| 3| 3| 5|            |
                                           | 7| 3| 3| 7| 6| 9| 3| 6| 6| 4| 5| 3| 6| 3| 2| 6| 1| 3| 3| 0| 6| 2| 6| 4| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
      Polyp Adenomatous                    |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                X         |          1 |
      Hemangiosarcoma                      |                            X                                             |          1 |
      Hepatocellular Carcinoma             |                   X                                            X  X      |          6 |
      Hepatocellular Carcinoma, Multiple   |                X                       X                                X|          4 |
      Hepatocellular Adenoma               |          X        X     X           X        X                    X      |         14 |
      Hepatocellular Adenoma, Multiple     |       X                                                                  |          3 |
      Hepatocholangiocarcinoma             |                                                 X                        |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                          +                          +         |   9        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                X         |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |       X                                            X                     |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 4| 7| 5| 7| 7| 6|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 6| 3| 5| 3| 3| 5|            |
                                           | 7| 3| 3| 7| 6| 9| 3| 6| 6| 4| 5| 3| 6| 3| 2| 6| 1| 3| 3| 0| 6| 2| 6| 4| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma                            |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +  +  I  +  +  M  +  M  +  M  +  +  M  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |             X     X     X           X  X  X                              |          8 |
      Pars Intermedia, Adenoma             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M|  40        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Polyp Stromal                        |                                              X     X                    X|          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                 +      |   4        |
      Inguinal, Lymphoma Malignant         |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|  41        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                X         |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                X                                                         |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  41        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +|  46        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  14                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 4| 7| 5| 7| 7| 6|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 6| 3| 5| 3| 3| 5|            |
                                           | 7| 3| 3| 7| 6| 9| 3| 6| 6| 4| 5| 3| 6| 3| 2| 6| 1| 3| 3| 0| 6| 2| 6| 4| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  M  M  +|  36        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                X         |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                X                                                         |          1 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  44        |
      Lymphoma Malignant                   |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   1        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X                                X                                       |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                X                       X                       X         |          5 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 4| 7| 5| 7| 7| 6|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 6| 3| 5| 3| 3| 5|            |
                                           | 7| 3| 3| 7| 6| 9| 3| 6| 6| 4| 5| 3| 6| 3| 2| 6| 1| 3| 3| 0| 6| 2| 6| 4| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
      Mediastinum,                         |                                                                          |            |
          Hepatocholangiocarcinoma,        |                                                                          |            |
          Metastatic, Liver                |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                      +   |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  16                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 7| 0| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 1| 0| 3| 1| 2| 3| 3| 3| 2| 7| 3| 3| 3| 3| 3| 7| 3| 0| 6| 3| 0| 3|             
                                           | 7| 5| 4| 5| 6| 7| 0| 1| 7| 7| 4| 9| 4| 3| 7| 7| 9| 7| 0| 4| 2| 6| 3| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Peyer's Patch, Lymphoma Malignant    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Peyer's Patch, Lymphoma Malignant    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                      X  X  X                             X     X  X  X   |             
      Hepatocellular Carcinoma, Multiple   |                                                 X                        |             
      Hepatocellular Adenoma               |       X  X     X                             X     X                     |             
      Hepatocellular Adenoma, Multiple     |                                        X                                 |             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +              +                                            +   |             
      Carcinoma, Metastatic, Ovary         |          X                                                               |             
      Hemangiosarcoma                      |       X                                                                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Carcinoma, Metastatic, Ovary         |          X                                                               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Carcinoma, Metastatic, Ovary         |          X                                                               |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  M  M  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  I  +|             
      Pars Distalis, Adenoma               | X     X                                                  X        X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  17                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 7| 0| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 1| 0| 3| 1| 2| 3| 3| 3| 2| 7| 3| 3| 3| 3| 3| 7| 3| 0| 6| 3| 0| 3|             
                                           | 7| 5| 4| 5| 6| 7| 0| 1| 7| 7| 4| 9| 4| 3| 7| 7| 9| 7| 0| 4| 2| 6| 3| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Adenoma             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |          X                                                               |             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant                   |                                     X                                    |             
      Teratoma Benign                      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma, Metastatic, Ovary         |          X                                                               |             
      Lymphoma Malignant                   |                                     X                                    |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                 +                                    |             
      Iliac, Lymphoma Malignant            |                                     X                                    |             
      Renal, Lymphoma Malignant            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  M  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  M|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Carcinoma, Metastatic, Ovary         |          X                                                               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Carcinoma, Metastatic, Ovary         |          X                                                               |             
      Lymphoma Malignant                   |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                         X           X     X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  +  I  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Lymphoma Malignant                   |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 7| 0| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 1| 0| 3| 1| 2| 3| 3| 3| 2| 7| 3| 3| 3| 3| 3| 7| 3| 0| 6| 3| 0| 3|             
                                           | 7| 5| 4| 5| 6| 7| 0| 1| 7| 7| 4| 9| 4| 3| 7| 7| 9| 7| 0| 4| 2| 6| 3| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                                                                        |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       | X                 X                                                      |             
      Carcinoma, Metastatic, Ovary         |          X                                                               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                      X         |             
      Lymphoma Malignant                   |                                     X                                    |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Mediastinum, Hemangiosarcoma         |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Carcinoma, Metastatic, Ovary         |          X                                                               |             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Lymphoma Malignant                   |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                         X           X     X                              |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7|            |
                             DAY ON TEST   | 7| 9| 9| 3| 0| 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 2| 3|            |
                                           | 4| 9| 0| 3| 8| 4| 1| 4| 6| 7| 3| 9| 4| 6| 6| 6| 7| 4| 7| 3| 0| 4| 0| 0| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                      X                 X                                 |          9 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |    X                 X        X  X  X              X        X  X         |         13 |
      Hepatocellular Adenoma, Multiple     |                X                       X     X                       X   |          5 |
      Lymphoma Malignant                   |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +     +        +     +        +                        |   9        |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant                   |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  20                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7|            |
                             DAY ON TEST   | 7| 9| 9| 3| 0| 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 2| 3|            |
                                           | 4| 9| 0| 3| 8| 4| 1| 4| 6| 7| 3| 9| 4| 6| 6| 6| 7| 4| 7| 3| 0| 4| 0| 0| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  +  M  M  +  +  I  M  +  +  M  +  +  +  +  +  M  +  +  +  M  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |    X  X     X              X  X              X  X     X                 X|         14 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |    X  X                                      X                           |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  43        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                                                          |          1 |
      Cystadenoma                          |          X                    X                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Teratoma Benign                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                         X|          1 |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          2 |
      Polyp Stromal                        |                                                             X  X         |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +     +                                                |   4        |
      Iliac, Lymphoma Malignant            |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  I  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +|  39        |
      Lymphoma Malignant                   |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  I|  39        |
      Lymphoma Malignant                   |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  47        |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                 X  X                     |          2 |
      Lymphoma Malignant                   |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  M  M  +  +|  41        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  21                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7|            |
                             DAY ON TEST   | 7| 9| 9| 3| 0| 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 2| 3|            |
                                           | 4| 9| 0| 3| 8| 4| 1| 4| 6| 7| 3| 9| 4| 6| 6| 6| 7| 4| 7| 3| 0| 4| 0| 0| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                              X                           |          1 |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Lymphoma Malignant                   |                   X                                                      |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M|  38        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Hemangioma      |                               X                                          |          1 |
      Subcutaneous Tissue, Sarcoma         | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |       X                                      X                           |          3 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                               X                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                      X                                                   |          3 |
      Lymphoma Malignant                   |                   X                                                      |          2 |
      Sarcoma, Metastatic, Skin            | X                                                                        |          1 |
      Mediastinum, Hemangiosarcoma         |                                              X                           |          1 |
      Mediastinum, Lymphoma Malignant      |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  22                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7|            |
                             DAY ON TEST   | 7| 9| 9| 3| 0| 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 2| 3|            |
                                           | 4| 9| 0| 3| 8| 4| 1| 4| 6| 7| 3| 9| 4| 6| 6| 6| 7| 4| 7| 3| 0| 4| 0| 0| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                       +                        |   2        |
      Adenoma                              |                         X                       X                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant                   |                   X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                 X  X                     |          2 |
      Lymphoma Malignant                   |                   X                                                      |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  23                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 6| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 3| 5| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7|             
                                           | 7| 4| 8| 4| 7| 2| 3| 8| 6| 1| 6| 6| 9| 4| 6| 3| 3| 4| 4| 3| 4| 3| 4| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1800 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X  X                             X     X           X     X  X   |             
      Hepatocellular Carcinoma, Multiple   |                               X  X     X                                X|             
      Hepatocellular Adenoma               |    X     X     X  X  X  X  X        X     X                 X     X     X|             
      Hepatocellular Adenoma, Multiple     | X                                                  X  X  X     X         |             
      Lymphoma Malignant                   |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                       +     +|             
      Fibrous Histiocytoma                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                        +                                 |             
      Squamous Cell Carcinoma              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pheochromocytoma Benign              |                                           X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  M  +  M  M  +  M  I  +  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |             X           X  X                    X     X  X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Carcinoma                    |                                           X                              |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  24                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 6| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 3| 5| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7|             
                                           | 7| 4| 8| 4| 7| 2| 3| 8| 6| 1| 6| 6| 9| 4| 6| 3| 3| 4| 4| 3| 4| 3| 4| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1800 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  I  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  I|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                         X|             
      Lymphoma Malignant                   |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  M  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                         X                                         X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                         X|             
      Lymphoma Malignant                   |                         X                                   X     X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X     X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                            X                          X        X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  25                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 6| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 3| 5| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7|             
                                           | 7| 4| 8| 4| 7| 2| 3| 8| 6| 1| 6| 6| 9| 4| 6| 3| 3| 4| 4| 3| 4| 3| 4| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1800 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                                                        X  X|             
      Alveolar/Bronchiolar Carcinoma       | X                                                                 X      |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                               X        X                          X      |             
      Lymphoma Malignant                   |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Mediastinum, Fibrous Histiocytoma,   |                                                                          |             
           Metastatic, Mesentery           |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
      Adenoma                              |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                         X                                   X     X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 2| 3| 6| 7| 4| 3| 3| 9|            |
                                           | 2| 6| 3| 6| 4| 3| 0| 4| 7| 3| 7| 7| 9| 6| 3| 3| 6| 7| 3| 2| 7| 5| 6| 4| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    1800 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hepatocellular Carcinoma             | X                                   X                    X               |         10 |
      Hepatocellular Carcinoma, Multiple   |                X                                                  X      |          6 |
      Hepatocellular Adenoma               |             X     X           X  X              X  X  X                  |         19 |
      Hepatocellular Adenoma, Multiple     |    X     X              X  X           X     X                    X      |         12 |
      Lymphoma Malignant                   |                   X                                                      |          1 |
      Osteosarcoma, Metastatic, Bone       |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                             +     +              +        +   |   9        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M|  45        |
      Pheochromocytoma Benign              |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M|  46        |
      Lymphoma Malignant                   |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  27                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 2| 3| 6| 7| 4| 3| 3| 9|            |
                                           | 2| 6| 3| 6| 4| 3| 0| 4| 7| 3| 7| 7| 9| 6| 3| 3| 6| 7| 3| 2| 7| 5| 6| 4| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    1800 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  A  M  M  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  A|  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Pars Distalis, Adenoma               | X                       X                                                |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  47        |
      C-Cell, Carcinoma                    |    X                                                                     |          2 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  I  M  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  M  +  +|  46        |
      Cystadenoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Polyp Stromal                        |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +  +  A|  46        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +              +                                                      |   2        |
      Lymphoma Malignant                   |                   X                                                      |          1 |
      Iliac, Lymphoma Malignant            |                   X                                                      |          1 |
      Pancreatic, Lymphoma Malignant       |                   X                                                      |          1 |
      Renal, Lymphoma Malignant            |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  A  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M|  41        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  A  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|  41        |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  45        |
      Lymphoma Malignant                   |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  M|  38        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
      Lymphoma Malignant                   |                   X                 X                                    |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  28                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 2| 3| 6| 7| 4| 3| 3| 9|            |
                                           | 2| 6| 3| 6| 4| 3| 0| 4| 7| 3| 7| 7| 9| 6| 3| 3| 6| 7| 3| 2| 7| 5| 6| 4| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    1800 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M|  44        |
      Lymphoma Malignant                   |                   X                                                      |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  49        |
      Osteosarcoma                         |                                  X                                      X|          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          3 |
      Lymphoma Malignant                   |                   X                                                      |          1 |
      Osteosarcoma, Metastatic, Bone       |                                  X                                       |          1 |
      Mediastinum, Fibrous Histiocytoma,   |                                                                          |            |
           Metastatic, Mesentery           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  A|  45        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  29                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 2| 3| 6| 7| 4| 3| 3| 9|            |
                                           | 2| 6| 3| 6| 4| 3| 0| 4| 7| 3| 7| 7| 9| 6| 3| 3| 6| 7| 3| 2| 7| 5| 6| 4| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    1800 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                   X                 X                                    |          5 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  30                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 1| 3| 3| 4| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 8| 3| 7| 5| 6| 3| 3|             
                                           | 0| 4| 6| 4| 9| 3| 7| 4| 4| 6| 7| 4| 0| 5| 6| 4| 6| 6| 2| 8| 8| 8| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  M  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  A  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |          X                                                     X         |             
      Hepatocellular Carcinoma, Multiple   |                      X     X           X                                 |             
      Hepatocellular Adenoma               |       X  X        X              X  X     X     X  X        X  X  X     X|             
      Hepatocellular Adenoma, Multiple     | X  X                                                     X               |             
      Hepatocholangiocarcinoma             |                                        X     X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +                           |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                              X                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
      Adenoma                              |                X                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Pars Distalis, Adenoma               |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Follicular Cell, Adenoma             |                                                    X                 X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  31                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 1| 3| 3| 4| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 8| 3| 7| 5| 6| 3| 3|             
                                           | 0| 4| 6| 4| 9| 3| 7| 4| 4| 6| 7| 4| 0| 5| 6| 4| 6| 6| 2| 8| 8| 8| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  M  M  M  +  +  +  +  +  +  M  +  M  +  M  +  +  A  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                              X                           |             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  M  +  +  M  +  M  +  M  +  M  M  +  M  +  +  M  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X     X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  M  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +     +                           |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X     X                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 1| 3| 3| 4| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 8| 3| 7| 5| 6| 3| 3|             
                                           | 0| 4| 6| 4| 9| 3| 7| 4| 4| 6| 7| 4| 0| 5| 6| 4| 6| 6| 2| 8| 8| 8| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X        X                    X                                       |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                            X                                             |             
      Alveolar/Bronchiolar Carcinoma       |       X                    X  X                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                      X                                                   |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X     X                           |             
      Mediastinum,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |                                        X     X                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +        +         |             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                                 |             
      Renal Tubule, Adenoma                |       X                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant                   |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 4| 5| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 3| 7| 0| 4| 6| 3| 3| 4| 1| 4| 4| 7| 3| 8| 9| 3| 3| 2| 6| 6| 6| 4| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Carcinoma                            |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Peyer's Patch, Lymphoma Malignant    |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                 X                        |          1 |
      Hepatocellular Carcinoma             | X        X                 X  X     X           X                 X  X   |         10 |
      Hepatocellular Carcinoma, Multiple   |                                                       X                  |          4 |
      Hepatocellular Adenoma               |       X  X              X              X                 X  X           X|         19 |
      Hepatocellular Adenoma, Multiple     |                      X                                         X         |          5 |
      Hepatocholangiocarcinoma             |                                                             X            |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   3        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                         X                                X               |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pheochromocytoma Benign              |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  I  +  +  +  M  +|  39        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  34                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 4| 5| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 3| 7| 0| 4| 6| 3| 3| 4| 1| 4| 4| 7| 3| 8| 9| 3| 3| 2| 6| 6| 6| 4| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  M  +  +  +  +|  45        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |             X                 X                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Sarcoma                              |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  M  M  +  +  +  M  M  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +|  33        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M|  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant                   |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  M  +  +  +  M  +  +|  36        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  I  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M  M|  35        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  35                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 4| 5| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 3| 7| 0| 4| 6| 3| 3| 4| 1| 4| 4| 7| 3| 8| 9| 3| 3| 2| 6| 6| 6| 4| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |    X  X  X  X     X     X              X              X  X  X  X     X  X|         16 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                X                                                         |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                     X  X                             X   |          6 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
      Mediastinum,                         |                                                                          |            |
          Hepatocholangiocarcinoma,        |                                                                          |            |
          Metastatic, Liver                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                             +                        |   4        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                   X                             X                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  36                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 4| 5| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 3| 7| 0| 4| 6| 3| 3| 4| 1| 4| 4| 7| 3| 8| 9| 3| 3| 2| 6| 6| 6| 4| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                          X               |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  37                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 5| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 0| 3| 4| 3| 2| 3| 3| 3| 3| 3| 7| 2| 3| 4|             
                                           | 4| 7| 4| 5| 3| 6| 6| 4| 6| 6| 6| 6| 6| 1| 7| 4| 4| 7| 6| 6| 4| 7| 6| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  A  +  +  +|             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  M  M  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |          X                                                               |             
      Hemangiosarcoma                      |                                  X                                       |             
      Hepatocellular Carcinoma             |          X                                                  X     X      |             
      Hepatocellular Carcinoma, Multiple   |                                        X  X                             X|             
      Hepatocellular Adenoma               |    X  X     X           X                    X  X              X         |             
      Hepatocellular Adenoma, Multiple     |                            X                          X     X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                         +                     |             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
      Hemangiosarcoma                      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
      Hemangiosarcoma                      |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  M  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  38                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 5| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 0| 3| 4| 3| 2| 3| 3| 3| 3| 3| 7| 2| 3| 4|             
                                           | 4| 7| 4| 5| 3| 6| 6| 4| 6| 6| 6| 6| 6| 1| 7| 4| 4| 7| 6| 6| 4| 7| 6| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  M  M  +  M  +  M  M|             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  +  M  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M  M|             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  M  +  +  +  I  +  +  +  +  M  +  +  +  M  M  +  +  M|             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Sarcoma                     |       X                                                                  |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Metastatic, Epididymis           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  39                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 5| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 0| 3| 4| 3| 2| 3| 3| 3| 3| 3| 7| 2| 3| 4|             
                                           | 4| 7| 4| 5| 3| 6| 6| 4| 6| 6| 6| 6| 6| 1| 7| 4| 4| 7| 6| 6| 4| 7| 6| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X              X              X         |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |             X           X     X                                      X   |             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                                 X                        |             
      Mediastinum, Hemangiosarcoma         |                                  X                                       |             
      Mediastinum, Lymphoma Malignant      |                                                 X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma, Metastatic, Liver|          X                                                               |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  40                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 3| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 3| 9| 1| 1| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 3| 3| 3| 4| 3|            |
                                           | 3| 7| 4| 4| 4| 4| 3| 4| 4| 4| 6| 8| 4| 2| 4| 7| 7| 3| 4| 5| 3| 6| 7| 6| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |             X  X                       X  X           X              X   |          9 |
      Hepatocellular Carcinoma, Multiple   |                            X                                             |          4 |
      Hepatocellular Adenoma               | X  X  X  X                    X                          X  X            |         14 |
      Hepatocellular Adenoma, Multiple     |                                     X           X                        |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   3        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  M  +  +  +  M  +  I  M  I  +  +  M  +  +  +  +  +  M  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  41                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 3| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 3| 9| 1| 1| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 3| 3| 3| 4| 3|            |
                                           | 3| 7| 4| 4| 4| 4| 3| 4| 4| 4| 6| 8| 4| 2| 4| 7| 7| 3| 4| 5| 3| 6| 7| 6| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sarcoma                              |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |             +        +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Adenoma           |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +        +                                   +   |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  M  +  +  +  +  M  M  +  M  +  +  +  +  +  M  M  +  +  +  M  +  +|  32        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  40        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  M  +|  40        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  M  +  I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  37        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prepuce, Sarcoma                     |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Metastatic, Epididymis           |             X                                                            |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  42                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 3| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 3| 9| 1| 1| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 3| 3| 3| 4| 3|            |
                                           | 3| 7| 4| 4| 4| 4| 3| 4| 4| 4| 6| 8| 4| 2| 4| 7| 7| 3| 4| 5| 3| 6| 7| 6| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                            X                 X                          X|          6 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                X                                                         |          1 |
      Alveolar/Bronchiolar Carcinoma       | X        X                             X                    X     X      |          9 |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                           X                              |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Mediastinum, Hemangiosarcoma         |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +  +                                                     +      |   4        |
      Adenoma                              |             X                                                     X      |          3 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                         +        +                                       |   3        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  43                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 3| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 3| 9| 1| 1| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 3| 3| 3| 4| 3|            |
                                           | 3| 7| 4| 4| 4| 4| 3| 4| 4| 4| 6| 8| 4| 2| 4| 7| 7| 3| 4| 5| 3| 6| 7| 6| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  44                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 6| 3| 3| 1| 9| 3| 3| 3| 5| 3| 5| 6|             
                                           | 6| 4| 3| 4| 7| 4| 1| 6| 3| 8| 4| 4| 6| 6| 6| 4| 2| 4| 4| 4| 7| 1| 4| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Carcinoma                            |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                     X                                    |             
      Hepatocellular Carcinoma             |          X  X     X                             X              X         |             
      Hepatocellular Carcinoma, Multiple   |                            X                                         X  X|             
      Hepatocellular Adenoma               |                         X     X  X        X              X               |             
      Hepatocellular Adenoma, Multiple     |                                              X                    X      |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Hemangioma                           |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +     +                           |             
      Odontoma                             |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  M  +  +  +  M  +  +  +  +  M  I  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Follicular Cell, Adenoma             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 6| 3| 3| 1| 9| 3| 3| 3| 5| 3| 5| 6|             
                                           | 6| 4| 3| 4| 7| 4| 1| 6| 3| 8| 4| 4| 6| 6| 6| 4| 2| 4| 4| 4| 7| 1| 4| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                    +                     |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +  M  M|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Lymphoma Malignant                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  I  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  I  +  M  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hemangiosarcoma                      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  M  M  +  +  +  +  +  M  M|             
      Lymphoma Malignant                   |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X        X                                X           X            |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                  X                                       |             
      Alveolar/Bronchiolar Carcinoma       |                      X        X                                          |             
      Carcinoma                            |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  46                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 6| 3| 3| 1| 9| 3| 3| 3| 5| 3| 5| 6|             
                                           | 6| 4| 3| 4| 7| 4| 1| 6| 3| 8| 4| 4| 6| 6| 6| 4| 2| 4| 4| 4| 7| 1| 4| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Liver                           |                            X                                            X|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
      Adenoma                              |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                       X  X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  47                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 3| 7| 5| 7| 5| 5| 7| 4| 5| 5| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 2| 3| 0| 3| 7| 3| 6| 3| 9| 7| 3| 4| 9| 5| 7| 3| 3| 8| 3| 3| 3|            |
                                           | 3| 6| 3| 4| 1| 4| 4| 4| 6| 6| 0| 3| 5| 4| 6| 0| 4| 4| 4| 7| 4| 2| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    600 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  I  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Carcinoma                            |       X                                                                  |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |       X                                                                  |          2 |
      Hepatocellular Carcinoma             |                   X     X                                      X         |          8 |
      Hepatocellular Carcinoma, Multiple   |          X                          X  X                                 |          6 |
      Hepatocellular Adenoma               | X     X     X  X     X        X  X           X                    X      |         14 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Hepatocholangiocarcinoma             |                                                       X                  |          1 |
      Histiocytic Sarcoma                  |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   2        |
      Hemangioma                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  A  +  +  +  +  I  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Odontoma                             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pheochromocytoma Benign              |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  A  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  +  +  +  M  M  +  M  +  +  M  +  +  M  +  M  M  M  M  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Adenoma               |                               X                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 3| 7| 5| 7| 5| 5| 7| 4| 5| 5| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 2| 3| 0| 3| 7| 3| 6| 3| 9| 7| 3| 4| 9| 5| 7| 3| 3| 8| 3| 3| 3|            |
                                           | 3| 6| 3| 4| 1| 4| 4| 4| 6| 6| 0| 3| 5| 4| 6| 0| 4| 4| 4| 7| 4| 2| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    600 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Lung          |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +              +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                             +     +                  |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  +  M  +  +  +  M  +  +  +  M  +  M  +  +  M  +  +  +|  36        |
      Carcinoma, Metastatic, Lung          |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Histiocytic Sarcoma                  |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +|  39        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  A  M  +  +  +  M  M  +  M  +  +  M  +  M  +  I  +  +  +  +  +  +|  34        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  49                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 3| 7| 5| 7| 5| 5| 7| 4| 5| 5| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 2| 3| 0| 3| 7| 3| 6| 3| 9| 7| 3| 4| 9| 5| 7| 3| 3| 8| 3| 3| 3|            |
                                           | 3| 6| 3| 4| 1| 4| 4| 4| 6| 6| 0| 3| 5| 4| 6| 0| 4| 4| 4| 7| 4| 2| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    600 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                X           X                                         X   |          7 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |    X  X     X                                                           X|          6 |
      Carcinoma                            |                                                    X                     |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                X         |          3 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                       X                  |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                 +                             +            |   4        |
      Adenoma                              |             X                                               X            |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                            X                                             |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  50                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 2| 2| 1| 4| 3| 7| 2| 7| 2| 5| 3| 7| 7| 6| 2| 1| 6| 3| 7| 1| 7| 3|             
                             DAY ON TEST   | 4| 2| 2| 3| 6| 9| 1| 5| 3| 4| 3| 7| 2| 1| 3| 3| 8| 7| 0| 5| 5| 3| 8| 3| 4|             
                                           | 0| 9| 1| 9| 0| 1| 4| 9| 3| 5| 6| 5| 7| 3| 6| 6| 7| 5| 2| 8| 9| 4| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1800 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  A  +  +  +  +  A  +  A  +  A  +  +  A  +  +  +  +  M  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  M  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  A  +  +  +  +  A  +  A  +  A  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  +  +  A  +  A  +  M  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  A  A  +  +  +  +  A  +  A  A  A  +  +  A  +  A  +  +  +  A  +  A|             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  A  +  +  +  +  A  +  A  +  A  +  +  A  +  A  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                              X           X               |             
      Hepatocellular Carcinoma, Multiple   |       X                                         X              X         |             
      Hepatocellular Adenoma               |                            X                       X                 X   |             
      Hepatocellular Adenoma, Multiple     |                                     X        X           X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  M  +  M  M  M  +  +  +  M  +  +  M  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                   +      |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   | +  +     +  +  +     +     +     +     +           +  +     +     +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 7| 2| 2| 1| 4| 3| 7| 2| 7| 2| 5| 3| 7| 7| 6| 2| 1| 6| 3| 7| 1| 7| 3|             
                             DAY ON TEST   | 4| 2| 2| 3| 6| 9| 1| 5| 3| 4| 3| 7| 2| 1| 3| 3| 8| 7| 0| 5| 5| 3| 8| 3| 4|             
                                           | 0| 9| 1| 9| 0| 1| 4| 9| 3| 5| 6| 5| 7| 3| 6| 6| 7| 5| 2| 8| 9| 4| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1800 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +                 +  +              +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  M  M  +  M  +  +  +  M  +  M  +  M  +  M  M  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  I  +  M  +  +  +  +  +  M  M  +  M  M  +  +  M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  +  +  +  M  +  M  +  M  +  +  M  +  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  M  +  +  +  +  +  M  M  I  +  +  +  +  M  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                 X                                            X   |             
      Alveolar/Bronchiolar Carcinoma       |                                                          X               |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Adenoma                              |                                                          X               |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |    +     +  +  +           +     +     +           +  +                 +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 7| 3| 7| 7| 6| 1| 7| 7| 7| 3| 0| 2| 3| 7| 5| 3| 0| 3| 6| 3| 3| 2|            |
                             DAY ON TEST   | 5| 1| 5| 3| 5| 3| 3| 7| 9| 0| 3| 3| 8| 9| 7| 2| 3| 5| 5| 0| 3| 3| 5| 4| 6|            |
                                           | 9| 5| 2| 4| 9| 6| 6| 0| 0| 6| 3| 4| 6| 9| 3| 1| 3| 4| 9| 7| 5| 9| 9| 9| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    1800 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  37        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             | X                             X                    X                     |          5 |
      Hepatocellular Carcinoma, Multiple   |                   X                                                      |          4 |
      Hepatocellular Adenoma               | X     X                    X  X                    X           X         |          9 |
      Hepatocellular Adenoma, Multiple     |    X                                            X                        |          5 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  I  M  +  +  +  M  +  +  M  +  +  +  M  M  +  +  M  +  M  +  +  +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +                       +  +        +  +  +  +        +  +  +     +  +  +|  27        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  53                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 7| 3| 7| 7| 6| 1| 7| 7| 7| 3| 0| 2| 3| 7| 5| 3| 0| 3| 6| 3| 3| 2|            |
                             DAY ON TEST   | 5| 1| 5| 3| 5| 3| 3| 7| 9| 0| 3| 3| 8| 9| 7| 2| 3| 5| 5| 0| 3| 3| 5| 4| 6|            |
                                           | 9| 5| 2| 4| 9| 6| 6| 0| 0| 6| 3| 4| 6| 9| 3| 1| 3| 4| 9| 7| 5| 9| 9| 9| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    1800 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  M  +  +  M  +  M  +  +  M  M  +  +  +  M  M  M  M  +  +  M|  26        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  +  +  M  M|  32        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +|  36        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |          4 |
      Alveolar/Bronchiolar Carcinoma       |    X           X                                                         |          3 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +     +                                          |   3        |
      Adenoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  54                                                               
NTP Experiment-Test: 05181-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 03/19/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:53:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 7| 3| 7| 7| 6| 1| 7| 7| 7| 3| 0| 2| 3| 7| 5| 3| 0| 3| 6| 3| 3| 2|            |
                             DAY ON TEST   | 5| 1| 5| 3| 5| 3| 3| 7| 9| 0| 3| 3| 8| 9| 7| 2| 3| 5| 5| 0| 3| 3| 5| 4| 6|            |
                                           | 9| 5| 2| 4| 9| 6| 6| 0| 0| 6| 3| 4| 6| 9| 3| 1| 3| 4| 9| 7| 5| 9| 9| 9| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    1800 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                       +                                +              +|  14        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  55                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------