TDMS Study 05181-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/21/96
EXPERIMENT: 05181 TEST: 04 TIME: 12:48:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. MILLER CAS: 0109-99-9
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/21/96
EXPERIMENT: 05181 TEST: 04 TIME: 12:48:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. MILLER CAS: 0109-99-9
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/21/96
EXPERIMENT: 05181 TEST: 04 TIME: 12:48:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. MILLER CAS: 0109-99-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TETRAHYDROFURAN
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Skin Sarcoma
Thyroid Gland: C-Cell Carcinoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/48 (6%) 1/50 (2%) 0/49 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/46 (0%) |
|ADJUSTED (b) | 9.4% 3.2% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/32 (9%) 1/31 (3%) 0/28 (0%) 0/12 (0%) | 0/29 (0%) 0/33 (0%) 0/26 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.194N P=0.316N P=0.145N P=0.336N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.194N P=0.316N P=0.145N P=0.336N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.194N P=0.316N P=0.145N P=0.336N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.094N | (e) |
|FISHER EXACT | P=0.293N P=0.117N P=0.114N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/50 (0%) 1/49 (2%) 0/50 (0%) | 0/49 (0%) 1/49 (2%) 0/50 (0%) 2/45 (4%) |
|ADJUSTED (b) | 3.1% 0.0% 3.4% 0.0% | 0.0% 3.0% 0.0% 5.6% |
|TERMINAL (d) | 1/32 (3%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 0/29 (0%) 1/33 (3%) 0/26 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 721 --- | --- 733 (T) --- 599 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.661N P=0.506N P=0.731 P=0.695N | P=0.155 P=0.526 (e) P=0.253 |
|INCIDENTAL TUMOR | P=0.573N P=0.506N P=0.669 P=0.695N | P=0.202 P=0.526 (e) P=0.345 |
|LOGISTIC REGRESSION | P=0.644N P=0.506N P=0.725 P=0.695N | P=0.141 P=0.526 (e) P=0.223 |
|COCHRAN-ARMITAGE | P=0.454N | P=0.130 |
|FISHER EXACT | P=0.490N P=0.747N P=0.490N | P=0.500 (e) P=0.226 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/50 (0%) 1/49 (2%) 0/50 (0%) | 0/49 (0%) 1/49 (2%) 1/50 (2%) 2/45 (4%) |
|ADJUSTED (b) | 3.1% 0.0% 3.4% 0.0% | 0.0% 3.0% 3.8% 5.6% |
|TERMINAL (d) | 1/32 (3%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 0/29 (0%) 1/33 (3%) 1/26 (4%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 721 --- | --- 733 (T) 733 (T) 599 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.661N P=0.506N P=0.731 P=0.695N | P=0.200 P=0.526 P=0.478 P=0.253 |
|INCIDENTAL TUMOR | P=0.573N P=0.506N P=0.669 P=0.695N | P=0.246 P=0.526 P=0.478 P=0.345 |
|LOGISTIC REGRESSION | P=0.644N P=0.506N P=0.725 P=0.695N | P=0.188 P=0.526 P=0.478 P=0.223 |
|COCHRAN-ARMITAGE | P=0.454N | P=0.169 |
|FISHER EXACT | P=0.490N P=0.747N P=0.490N | P=0.500 P=0.505 P=0.226 |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.4% 3.0% 0.0% 5.5% |
|TERMINAL (d) | 0/32 (0%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 1/29 (3%) 1/33 (3%) 0/26 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 733 (T) 733 (T) --- 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.350 P=0.733N P=0.522N P=0.532 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.408 P=0.733N P=0.522N P=0.620 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.347 P=0.733N P=0.522N P=0.527 |
|COCHRAN-ARMITAGE | (e) | P=0.332 |
|FISHER EXACT | (e) (e) (e) | P=0.753N P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 3/50 (6%) 1/50 (2%) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 2.5% 9.7% 10.3% 5.6% | 6.1% 3.0% 7.7% 3.1% |
|TERMINAL (d) | 0/32 (0%) 3/31 (10%) 2/28 (7%) 0/12 (0%) | 1/29 (3%) 1/33 (3%) 2/26 (8%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 658 733 (T) 721 658 | 604 733 (T) 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.485 P=0.289 P=0.255 P=0.574 | P=0.459N P=0.458N P=0.669 P=0.471N |
|INCIDENTAL TUMOR | P=0.585 P=0.273 P=0.171 P=0.702 | P=0.410N P=0.431N P=0.683N P=0.380N |
|LOGISTIC REGRESSION | P=0.533 P=0.284 P=0.262 P=0.664 | P=0.460N P=0.473N P=0.672N P=0.473N |
|COCHRAN-ARMITAGE | P=0.418N | P=0.476N |
|FISHER EXACT | P=0.309 P=0.309 P=0.753N | P=0.500N P=0.691N P=0.500N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.3% 0.0% 0.0% 8.3% | 0.0% 3.0% 0.0% 0.0% |
|TERMINAL (d) | 2/32 (6%) 0/31 (0%) 0/28 (0%) 1/12 (8%) | 0/29 (0%) 1/33 (3%) 0/26 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 582 --- --- 733 (T) | --- 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.694 P=0.135N P=0.148N P=0.669N | P=0.575N P=0.526 (e) (e) |
|INCIDENTAL TUMOR | P=0.708 P=0.127N P=0.088N P=0.690N | P=0.575N P=0.526 (e) (e) |
|LOGISTIC REGRESSION | P=0.646N P=0.121N P=0.121N P=0.579N | P=0.575N P=0.526 (e) (e) |
|COCHRAN-ARMITAGE | P=0.442N | P=0.585N |
|FISHER EXACT | P=0.121N P=0.121N P=0.309N | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 3/50 (6%) 2/50 (4%) | 2/50 (4%) 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 10.6% 9.7% 10.3% 13.4% | 6.1% 6.1% 7.7% 3.1% |
|TERMINAL (d) | 2/32 (6%) 3/31 (10%) 2/28 (7%) 1/12 (8%) | 1/29 (3%) 2/33 (6%) 2/26 (8%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 582 733 (T) 721 658 | 604 733 (T) 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.479 P=0.531N P=0.578N P=0.585 | P=0.364N P=0.649N P=0.669 P=0.471N |
|INCIDENTAL TUMOR | P=0.568 P=0.534N P=0.585N P=0.651 | P=0.323N P=0.628N P=0.683N P=0.380N |
|LOGISTIC REGRESSION | P=0.559 P=0.521N P=0.540N P=0.653N | P=0.365N P=0.664N P=0.672N P=0.473N |
|COCHRAN-ARMITAGE | P=0.304N | P=0.381N |
|FISHER EXACT | P=0.500N P=0.500N P=0.339N | P=0.691N P=0.691N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/48 (0%) |
|ADJUSTED (b) | 3.1% 3.0% 7.1% 0.0% | 0.0% 3.0% 0.0% 0.0% |
|TERMINAL (d) | 1/32 (3%) 0/31 (0%) 2/28 (7%) 0/12 (0%) | 0/29 (0%) 1/33 (3%) 0/26 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 706 733 (T) --- | --- 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.587N P=0.753 P=0.453 P=0.695N | P=0.575N P=0.526 (e) (e) |
|INCIDENTAL TUMOR | P=0.534N P=0.725 P=0.453 P=0.695N | P=0.575N P=0.526 (e) (e) |
|LOGISTIC REGRESSION | P=0.566N P=0.749 P=0.453 P=0.695N | P=0.575N P=0.526 (e) (e) |
|COCHRAN-ARMITAGE | P=0.332N | P=0.593N |
|FISHER EXACT | P=0.753N P=0.500 P=0.500N | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 19/50 (38%) 16/50 (32%) 14/50 (28%) | 12/50 (24%) 17/50 (34%) 18/50 (36%) 31/48 (65%) |
|ADJUSTED (b) | 60.5% 53.4% 48.7% 59.0% | 35.9% 47.1% 52.5% 76.8% |
|TERMINAL (d) | 17/32 (53%) 15/31 (48%) 12/28 (43%) 4/12 (33%) | 8/29 (28%) 14/33 (42%) 11/26 (42%) 23/32 (72%) |
|FIRST INCIDENCE (DAYS) | 362 324 440 245 | 648 640 469 399 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.097 P=0.273N P=0.199N P=0.181 | P<0.001 ** P=0.313 P=0.119 P=0.001 ** |
|INCIDENTAL TUMOR | P=0.389N P=0.224N P=0.203N P=0.395N | P<0.001 ** P=0.196 P=0.197 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.506N P=0.211N P=0.142N P=0.414N | P<0.001 ** P=0.249 P=0.188 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.041N* | P<0.001 ** |
|FISHER EXACT | P=0.210N P=0.076N P=0.032N* | P=0.189 P=0.138 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 13/50 (26%) 14/50 (28%) 9/50 (18%) | 6/50 (12%) 10/50 (20%) 10/50 (20%) 16/48 (33%) |
|ADJUSTED (b) | 33.3% 28.9% 31.4% 50.0% | 16.5% 26.3% 30.0% 40.8% |
|TERMINAL (d) | 6/32 (19%) 3/31 (10%) 2/28 (7%) 4/12 (33%) | 2/29 (7%) 6/33 (18%) 5/26 (19%) 10/32 (31%) |
|FIRST INCIDENCE (DAYS) | 481 441 376 359 | 478 552 544 562 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161 P=0.557N P=0.455 P=0.190 | P=0.027 * P=0.297 P=0.210 P=0.035 * |
|INCIDENTAL TUMOR | P=0.555N P=0.425N P=0.352N P=0.518 | P=0.028 * P=0.242 P=0.319 P=0.042 * |
|LOGISTIC REGRESSION | P=0.459 P=0.412N P=0.270N P=0.363 | P=0.012 * P=0.234 P=0.229 P=0.014 * |
|COCHRAN-ARMITAGE | P=0.136N | P=0.009 ** |
|FISHER EXACT | P=0.500N P=0.588N P=0.171N | P=0.207 P=0.207 P=0.011 * |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 35/50 (70%) 31/50 (62%) 30/50 (60%) 18/50 (36%) | 17/50 (34%) 24/50 (48%) 26/50 (52%) 41/48 (85%) |
|ADJUSTED (b) | 77.2% 67.9% 66.9% 73.4% | 46.3% 61.3% 69.1% 93.0% |
|TERMINAL (d) | 22/32 (69%) 17/31 (55%) 14/28 (50%) 6/12 (50%) | 10/29 (34%) 18/33 (55%) 15/26 (58%) 29/32 (91%) |
|FIRST INCIDENCE (DAYS) | 362 324 376 245 | 478 552 469 399 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.181 P=0.407N P=0.501N P=0.237 | P<0.001 ** P=0.253 P=0.056 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.098N P=0.213N P=0.185N P=0.171N | P<0.001 ** P=0.149 P=0.118 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.105N P=0.210N P=0.121N P=0.175N | P<0.001 ** P=0.188 P=0.086 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001N** | P<0.001 ** |
|FISHER EXACT | P=0.263N P=0.201N P<0.001N** | P=0.111 P=0.053 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 35/50 (70%) 31/50 (62%) 30/50 (60%) 18/50 (36%) | 17/50 (34%) 24/50 (48%) 26/50 (52%) 41/48 (85%) |
|ADJUSTED (b) | 77.2% 67.9% 66.9% 73.4% | 46.3% 61.3% 69.1% 93.0% |
|TERMINAL (d) | 22/32 (69%) 17/31 (55%) 14/28 (50%) 6/12 (50%) | 10/29 (34%) 18/33 (55%) 15/26 (58%) 29/32 (91%) |
|FIRST INCIDENCE (DAYS) | 362 324 376 245 | 478 552 469 399 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.181 P=0.407N P=0.501N P=0.237 | P<0.001 ** P=0.253 P=0.056 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.098N P=0.213N P=0.185N P=0.171N | P<0.001 ** P=0.149 P=0.118 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.105N P=0.210N P=0.121N P=0.175N | P<0.001 ** P=0.188 P=0.086 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001N** | P<0.001 ** |
|FISHER EXACT | P=0.263N P=0.201N P<0.001N** | P=0.111 P=0.053 P<0.001 ** |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocholangiocarcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/48 (0%) |
|ADJUSTED (b) | 8.7% 0.0% 2.4% 0.0% | 5.6% 2.4% 0.0% 0.0% |
|TERMINAL (d) | 2/32 (6%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 0/29 (0%) 0/33 (0%) 0/26 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 675 --- 574 --- | 630 601 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.303N P=0.132N P=0.362N P=0.329N | P=0.174N P=0.467N P=0.231N P=0.243N |
|INCIDENTAL TUMOR | P=0.260N P=0.144N P=0.313N P=0.276N | P=0.114N P=0.468N P=0.140N P=0.215N |
|LOGISTIC REGRESSION | P=0.219N P=0.130N P=0.305N P=0.291N | P=0.182N P=0.511N P=0.236N P=0.246N |
|COCHRAN-ARMITAGE | P=0.156N | P=0.174N |
|FISHER EXACT | P=0.121N P=0.309N P=0.121N | P=0.500N P=0.247N P=0.258N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/50 (36%) 7/50 (14%) 8/50 (16%) 4/50 (8%) | 1/50 (2%) 2/50 (4%) 4/50 (8%) 3/49 (6%) |
|ADJUSTED (b) | 51.0% 19.0% 26.6% 30.8% | 3.4% 6.1% 14.2% 8.4% |
|TERMINAL (d) | 15/32 (47%) 3/31 (10%) 7/28 (25%) 3/12 (25%) | 1/29 (3%) 2/33 (6%) 3/26 (12%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 582 554 512 721 | 733 (T) 733 (T) 690 574 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.230N P=0.017N* P=0.043N* P=0.183N | P=0.332 P=0.545 P=0.158 P=0.344 |
|INCIDENTAL TUMOR | P=0.148N P=0.017N* P=0.038N* P=0.129N | P=0.342 P=0.545 P=0.182 P=0.410 |
|LOGISTIC REGRESSION | P=0.137N P=0.014N* P=0.043N* P=0.110N | P=0.321 P=0.545 P=0.186 P=0.330 |
|COCHRAN-ARMITAGE | P=0.004N** | P=0.294 |
|FISHER EXACT | P=0.010N** P=0.020N* P<0.001N** | P=0.500 P=0.181 P=0.301 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 9/50 (18%) 7/50 (14%) 3/50 (6%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) 2/49 (4%) |
|ADJUSTED (b) | 17.5% 25.4% 21.4% 19.6% | 3.4% 3.0% 6.3% 5.6% |
|TERMINAL (d) | 5/32 (16%) 6/31 (19%) 4/28 (14%) 1/12 (8%) | 1/29 (3%) 1/33 (3%) 1/26 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 557 532 554 658 | 733 (T) 733 (T) 610 604 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.538 P=0.261 P=0.408 P=0.509 | P=0.400 P=0.733N P=0.484 P=0.529 |
|INCIDENTAL TUMOR | P=0.519N P=0.283 P=0.532 P=0.574 | P=0.499 P=0.733N P=0.528 P=0.620 |
|LOGISTIC REGRESSION | P=0.455N P=0.263 P=0.455 P=0.619 | P=0.396 P=0.733N P=0.523 P=0.524 |
|COCHRAN-ARMITAGE | P=0.097N | P=0.375 |
|FISHER EXACT | P=0.288 P=0.500 P=0.243N | P=0.753N P=0.500 P=0.492 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 16/50 (32%) 15/50 (30%) 7/50 (14%) | 2/50 (4%) 3/50 (6%) 5/50 (10%) 5/49 (10%) |
|ADJUSTED (b) | 57.7% 41.1% 45.5% 46.0% | 6.9% 9.1% 16.4% 13.7% |
|TERMINAL (d) | 17/32 (53%) 9/31 (29%) 11/28 (39%) 4/12 (33%) | 2/29 (7%) 3/33 (9%) 3/26 (12%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 557 532 512 658 | 733 (T) 733 (T) 610 574 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.437N P=0.270N P=0.288N P=0.444N | P=0.220 P=0.559 P=0.196 P=0.259 |
|INCIDENTAL TUMOR | P=0.250N P=0.258N P=0.199N P=0.318N | P=0.279 P=0.559 P=0.241 P=0.354 |
|LOGISTIC REGRESSION | P=0.213N P=0.248N P=0.248N P=0.280N | P=0.212 P=0.559 P=0.241 P=0.245 |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.183 |
|FISHER EXACT | P=0.204N P=0.149N P=0.002N** | P=0.500 P=0.218 P=0.210 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/49 (0%) 0/50 (0%) 2/50 (4%) 1/46 (2%) |
|ADJUSTED (b) | | 0.0% 0.0% 7.7% 3.3% |
|TERMINAL (d) | | 0/29 (0%) 0/33 (0%) 2/26 (8%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | | --- --- 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.351 (e) P=0.214 P=0.507 |
|INCIDENTAL TUMOR | | P=0.351 (e) P=0.214 P=0.507 |
|LOGISTIC REGRESSION | | P=0.351 (e) P=0.214 P=0.507 |
|COCHRAN-ARMITAGE | | P=0.332 |
|FISHER EXACT | | (e) P=0.253 P=0.484 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/45 (2%) 0/47 (0%) 1/45 (2%) 0/47 (0%) | 10/47 (21%) 8/48 (17%) 14/48 (29%) 8/48 (17%) |
|ADJUSTED (b) | 3.2% 0.0% 2.3% 0.0% | 32.7% 23.4% 47.3% 23.4% |
|TERMINAL (d) | 1/31 (3%) 0/30 (0%) 0/27 (0%) 0/12 (0%) | 7/27 (26%) 6/31 (19%) 11/26 (42%) 6/32 (19%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 560 --- | 651 582 599 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.648N P=0.507N P=0.740 P=0.689N | P=0.306N P=0.292N P=0.222 P=0.287N |
|INCIDENTAL TUMOR | P=0.635N P=0.507N P=0.667N P=0.689N | P=0.308N P=0.331N P=0.338 P=0.342N |
|LOGISTIC REGRESSION | P=0.485N P=0.507N P=0.735N P=0.689N | P=0.298N P=0.285N P=0.330 P=0.267N |
|COCHRAN-ARMITAGE | P=0.454N | P=0.386N |
|FISHER EXACT | P=0.489N P=0.753N P=0.489N | P=0.378N P=0.259 P=0.378N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 3.2% 0.0% 0.0% | 0.0% 0.0% 2.4% 8.9% |
|TERMINAL (d) | 0/32 (0%) 1/31 (3%) 0/28 (0%) 0/12 (0%) | 0/29 (0%) 0/33 (0%) 0/26 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) --- --- | --- --- 574 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.749N P=0.494 (e) (e) | P=0.025 * (e) P=0.515 P=0.136 |
|INCIDENTAL TUMOR | P=0.749N P=0.494 (e) (e) | P=0.054 (e) P=0.594 P=0.186 |
|LOGISTIC REGRESSION | P=0.749N P=0.494 (e) (e) | P=0.022 * (e) P=0.476 P=0.135 |
|COCHRAN-ARMITAGE | P=0.585N | P=0.021 * |
|FISHER EXACT | P=0.500 (e) (e) | (e) P=0.500 P=0.121 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.4% 6.1% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 1/29 (3%) 2/33 (6%) 0/26 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 733 (T) 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.209N P=0.545 P=0.522N P=0.480N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.209N P=0.545 P=0.522N P=0.480N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.209N P=0.545 P=0.522N P=0.480N |
|COCHRAN-ARMITAGE | (e) | P=0.214N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/49 (0%) 0/49 (0%) | 0/50 (0%) 0/50 (0%) 0/49 (0%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 6.3% |
|TERMINAL (d) | 0/32 (0%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 0/29 (0%) 0/33 (0%) 0/26 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.049 * (e) (e) P=0.260 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.049 * (e) (e) P=0.260 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.049 * (e) (e) P=0.260 |
|COCHRAN-ARMITAGE | (e) | P=0.037 * |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.232 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/49 (0%) 0/49 (0%) | 1/50 (2%) 0/50 (0%) 0/49 (0%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.4% 0.0% 0.0% 6.3% |
|TERMINAL (d) | 0/32 (0%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 1/29 (3%) 0/33 (0%) 0/26 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 733 (T) --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.206 P=0.474N P=0.522N P=0.535 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.206 P=0.474N P=0.522N P=0.535 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.206 P=0.474N P=0.522N P=0.535 |
|COCHRAN-ARMITAGE | (e) | P=0.177 |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.505N P=0.477 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 0/50 (0%) 1/49 (2%) 1/49 (2%) | 2/50 (4%) 1/50 (2%) 3/49 (6%) 1/47 (2%) |
|ADJUSTED (b) | 12.5% 0.0% 3.6% 7.1% | 6.9% 3.0% 9.1% 3.1% |
|TERMINAL (d) | 4/32 (13%) 0/31 (0%) 1/28 (4%) 0/12 (0%) | 2/29 (7%) 1/33 (3%) 1/26 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 733 (T) 715 | 733 (T) 733 (T) 599 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.613N P=0.066N P=0.220N P=0.548N | P=0.451N P=0.455N P=0.481 P=0.465N |
|INCIDENTAL TUMOR | P=0.567N P=0.066N P=0.220N P=0.492N | P=0.443N P=0.455N P=0.558 P=0.465N |
|LOGISTIC REGRESSION | P=0.590N P=0.066N P=0.220N P=0.517N | P=0.460N P=0.455N P=0.530 P=0.465N |
|COCHRAN-ARMITAGE | P=0.299N | P=0.494N |
|FISHER EXACT | P=0.056N P=0.181N P=0.181N | P=0.500N P=0.490 P=0.523N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 0/50 (0%) 1/49 (2%) 1/49 (2%) | 3/50 (6%) 1/50 (2%) 3/49 (6%) 1/47 (2%) |
|ADJUSTED (b) | 12.5% 0.0% 3.6% 7.1% | 10.3% 3.0% 9.1% 3.1% |
|TERMINAL (d) | 4/32 (13%) 0/31 (0%) 1/28 (4%) 0/12 (0%) | 3/29 (10%) 1/33 (3%) 1/26 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 733 (T) 715 | 733 (T) 733 (T) 599 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.613N P=0.066N P=0.220N P=0.548N | P=0.325N P=0.259N P=0.637 P=0.269N |
|INCIDENTAL TUMOR | P=0.567N P=0.066N P=0.220N P=0.492N | P=0.317N P=0.259N P=0.622N P=0.269N |
|LOGISTIC REGRESSION | P=0.590N P=0.066N P=0.220N P=0.517N | P=0.331N P=0.259N P=0.633N P=0.269N |
|COCHRAN-ARMITAGE | P=0.299N | P=0.365N |
|FISHER EXACT | P=0.056N P=0.181N P=0.181N | P=0.309N P=0.651 P=0.332N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 4/50 (8%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | | 2.9% 10.6% 6.7% 2.3% |
|TERMINAL (d) | | 0/29 (0%) 2/33 (6%) 1/26 (4%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | | 651 526 680 577 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.328N P=0.221 P=0.501 P=0.747N |
|INCIDENTAL TUMOR | | P=0.371N P=0.135 P=0.606 P=0.759N |
|LOGISTIC REGRESSION | | P=0.336N P=0.186 P=0.522 P=0.753 |
|COCHRAN-ARMITAGE | | P=0.340N |
|FISHER EXACT | | P=0.181 P=0.500 P=0.753N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 3/50 (6%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 3.1% 6.2% 7.1% 8.3% | 2.6% 8.5% 7.7% 0.0% |
|TERMINAL (d) | 1/32 (3%) 1/31 (3%) 2/28 (7%) 1/12 (8%) | 0/29 (0%) 2/33 (6%) 2/26 (8%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 706 733 (T) 733 (T) | 599 640 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.448 P=0.489 P=0.453 P=0.529 | P=0.183N P=0.347 P=0.481 P=0.490N |
|INCIDENTAL TUMOR | P=0.490 P=0.459 P=0.453 P=0.529 | P=0.127N P=0.390 P=0.528 P=0.326N |
|LOGISTIC REGRESSION | P=0.473 P=0.477 P=0.453 P=0.529 | P=0.175N P=0.324 P=0.522 P=0.525N |
|COCHRAN-ARMITAGE | P=0.524N | P=0.187N |
|FISHER EXACT | P=0.500 P=0.500 P=0.753N | P=0.309 P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 3/50 (6%) 1/50 (2%) | 2/50 (4%) 3/50 (6%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 5.9% 6.2% 10.7% 8.3% | 4.9% 8.5% 11.5% 0.0% |
|TERMINAL (d) | 1/32 (3%) 1/31 (3%) 3/28 (11%) 1/12 (8%) | 0/29 (0%) 2/33 (6%) 3/26 (12%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 699 706 733 (T) 733 (T) | 495 640 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.529 P=0.679 P=0.434 P=0.673 | P=0.124N P=0.549 P=0.483 P=0.220N |
|INCIDENTAL TUMOR | P=0.596 P=0.637 P=0.391 P=0.724 | P=0.095N P=0.564 P=0.512 P=0.191N |
|LOGISTIC REGRESSION | P=0.559 P=0.673 P=0.422 P=0.698 | P=0.121N P=0.497 P=0.513 P=0.283N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.128N |
|FISHER EXACT | P=0.691N P=0.500 P=0.500N | P=0.500 P=0.500 P=0.247N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 3/50 (6%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 3.1% 0.0% 3.6% 0.0% | 7.6% 0.0% 6.2% 0.0% |
|TERMINAL (d) | 1/32 (3%) 0/31 (0%) 1/28 (4%) 0/12 (0%) | 0/29 (0%) 0/33 (0%) 1/26 (4%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 733 (T) --- | 442 --- 594 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.668N P=0.506N P=0.732 P=0.695N | P=0.170N P=0.109N P=0.487N P=0.113N |
|INCIDENTAL TUMOR | P=0.668N P=0.506N P=0.732 P=0.695N | P=0.134N P=0.139N P=0.381N P=0.131N |
|LOGISTIC REGRESSION | P=0.668N P=0.506N P=0.732 P=0.695N | P=0.194N P=0.140N P=0.528N P=0.145N |
|COCHRAN-ARMITAGE | P=0.459N | P=0.173N |
|FISHER EXACT | P=0.500N P=0.753N P=0.500N | P=0.121N P=0.500N P=0.121N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 0/50 (0%) | 7/50 (14%) 2/50 (4%) 4/50 (8%) 5/50 (10%) |
|ADJUSTED (b) | 6.3% 3.2% 7.1% 0.0% | 21.4% 5.5% 12.7% 13.3% |
|TERMINAL (d) | 2/32 (6%) 1/31 (3%) 2/28 (7%) 0/12 (0%) | 5/29 (17%) 1/33 (3%) 2/26 (8%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) 733 (T) --- | 502 635 631 599 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445N P=0.511N P=0.647 P=0.471N | P=0.573N P=0.059N P=0.288N P=0.324N |
|INCIDENTAL TUMOR | P=0.445N P=0.511N P=0.647 P=0.471N | P=0.426N P=0.054N P=0.229N P=0.192N |
|LOGISTIC REGRESSION | P=0.445N P=0.511N P=0.647 P=0.471N | P=0.576N P=0.066N P=0.227N P=0.343N |
|COCHRAN-ARMITAGE | P=0.209N | P=0.570 |
|FISHER EXACT | P=0.500N P=0.691N P=0.247N | P=0.080N P=0.262N P=0.380N |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.4% 3.0% 0.0% 5.5% |
|TERMINAL (d) | 0/32 (0%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 1/29 (3%) 1/33 (3%) 0/26 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 733 (T) 733 (T) --- 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.350 P=0.733N P=0.522N P=0.532 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.408 P=0.733N P=0.522N P=0.620 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.347 P=0.733N P=0.522N P=0.527 |
|COCHRAN-ARMITAGE | (e) | P=0.332 |
|FISHER EXACT | (e) (e) (e) | P=0.753N P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.4% 3.0% 0.0% 5.5% |
|TERMINAL (d) | 0/32 (0%) 0/31 (0%) 0/28 (0%) 0/12 (0%) | 1/29 (3%) 1/33 (3%) 0/26 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 733 (T) 733 (T) --- 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.350 P=0.733N P=0.522N P=0.532 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.408 P=0.733N P=0.522N P=0.620 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.347 P=0.733N P=0.522N P=0.527 |
|COCHRAN-ARMITAGE | (e) | P=0.332 |
|FISHER EXACT | (e) (e) (e) | P=0.753N P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 36/50 (72%) 27/50 (54%) 26/50 (52%) 17/50 (34%) | 21/50 (42%) 29/50 (58%) 31/50 (62%) 37/50 (74%) |
|ADJUSTED (b) | 85.4% 70.5% 75.7% 71.6% | 56.6% 72.4% 85.6% 85.7% |
|TERMINAL (d) | 26/32 (81%) 20/31 (65%) 20/28 (71%) 6/12 (50%) | 13/29 (45%) 22/33 (67%) 21/26 (81%) 26/32 (81%) |
|FIRST INCIDENCE (DAYS) | 362 324 440 245 | 495 526 469 399 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.187 P=0.109N P=0.176N P=0.336 | P=0.014 * P=0.235 P=0.031 * P=0.016 * |
|INCIDENTAL TUMOR | P=0.161N P=0.066N P=0.157N P=0.136N | P=0.005 ** P=0.072 P=0.062 P=0.004 ** |
|LOGISTIC REGRESSION | P=0.327N P=0.056N P=0.103N P=0.167N | P=0.005 ** P=0.159 P=0.064 P=0.004 ** |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.002 ** |
|FISHER EXACT | P=0.048N* P=0.032N* P<0.001N** | P=0.081 P=0.036 * P=0.001 ** |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 25/50 (50%) 26/50 (52%) 12/50 (24%) | 21/50 (42%) 18/50 (36%) 21/50 (42%) 28/50 (56%) |
|ADJUSTED (b) | 56.0% 55.7% 57.5% 65.2% | 51.6% 44.4% 54.8% 64.6% |
|TERMINAL (d) | 14/32 (44%) 12/31 (39%) 10/28 (36%) 6/12 (50%) | 10/29 (34%) 11/33 (33%) 10/26 (38%) 17/32 (53%) |
|FIRST INCIDENCE (DAYS) | 481 441 376 359 | 442 552 544 562 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.290 P=0.424 P=0.261 P=0.306 | P=0.091 P=0.227N P=0.537 P=0.258 |
|INCIDENTAL TUMOR | P=0.348N P=0.516 P=0.490N P=0.552N | P=0.171 P=0.235N P=0.318N P=0.388 |
|LOGISTIC REGRESSION | P=0.430N P=0.504 P=0.547N P=0.570 | P=0.098 P=0.211N P=0.344N P=0.280 |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.036 * |
|FISHER EXACT | P=0.500 P=0.421 P=0.011N* | P=0.341N P=0.580N P=0.115 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 47/50 (94%) 39/50 (78%) 44/50 (88%) 21/50 (42%) | 34/50 (68%) 38/50 (76%) 41/50 (82%) 44/50 (88%) |
|ADJUSTED (b) | 95.9% 82.7% 93.4% 86.7% | 79.0% 86.3% 95.3% 93.5% |
|TERMINAL (d) | 30/32 (94%) 23/31 (74%) 25/28 (89%) 9/12 (75%) | 20/29 (69%) 27/33 (82%) 24/26 (92%) 29/32 (91%) |
|FIRST INCIDENCE (DAYS) | 362 324 376 245 | 442 526 469 399 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.224 P=0.216N P=0.388 P=0.386 | P=0.131 P=0.546N P=0.115 P=0.188 |
|INCIDENTAL TUMOR | P=0.013N* P=0.023N* P=0.300N P=0.010N* | P=0.124 P=0.415 P=0.272 P=0.151 |
|LOGISTIC REGRESSION | P=0.017N* P=0.020N* P=0.225N P=0.011N* | P=0.049 * P=0.490 P=0.204 P=0.059 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.016 * |
|FISHER EXACT | P=0.020N* P=0.243N P<0.001N** | P=0.252 P=0.083 P=0.014 * |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).