TDMS Study 05181-04 Pathology Tables
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0109-99-9
Lock Date: 03/24/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3|
| 6| 6| 7| 4| 6| 9| 9| 9| 9| 9| 7| 6| 7| 0| 3| 4| 5| 6| 7| 6| 6| 7| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A A + A A + + + + + + + + + + + + + + +|
Degeneration, Hyaline | |
Inflammation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + M M + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + M M + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A A + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Eosinophilic Focus | X |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 2 |
Necrosis | 3 2 |
Pigmentation | |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | |
Hypertrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 4 |
Ulcer | 2 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
Erosion | 1 |
Infiltration Cellular, Mast Cell | 4 |
Inflammation, Suppurative | 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1|
Hemorrhage | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3|
| 6| 6| 7| 4| 6| 9| 9| 9| 9| 9| 7| 6| 7| 0| 3| 4| 5| 6| 7| 6| 6| 7| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | |
Necrosis | |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + M M I + + M + M + + + M M + + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + + +|
Hyperplasia | |
Pars Distalis, Hyperplasia | 4 2 3 2 2 1|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Inflammation | |
Follicular Cell, Hyperplasia | 1 1 4 1 4 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + M + + M + + + + + M + + + M + + + + M +|
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Angiectasis | 2|
Atrophy | 2 3 2 3 |
Cyst | 4 2 2 3 2 1 1 3 3 1 1|
Hyperplasia | 3 |
Granulosa Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + A + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hydrometra | 2 4 |
Hyperplasia, Cystic | 1 3 1 2 2 2 2 2 1 2 2 2 2 2 3 2 1|
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3|
| 6| 6| 7| 4| 6| 9| 9| 9| 9| 9| 7| 6| 7| 0| 3| 4| 5| 6| 7| 6| 6| 7| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 3 |
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia | 2 |
Lumbar, Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + M M + M + + + + M + M + + + M M M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M M + + + + + M M + M + + + + M + + + M + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + M + + A M + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + M M M M M + + M + M + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 2 4 |
__________________________________________________________________________|
Thymus | + + + + M + + M + + + M + + + + + + + + + + + M +|
Amyloid Deposition | 4 |
Atrophy | 3 4 3 4 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 1 2 1 2 1 1 1 2 1|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3|
| 6| 6| 7| 4| 6| 9| 9| 9| 9| 9| 7| 6| 7| 0| 3| 4| 5| 6| 7| 6| 6| 7| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 2 2 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 1 1 1|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M A + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 7| 5| 4| 7| 4| 5| 7| 7| 6| 7| 7| 4| 6| 7| 7| |
DAY ON TEST | 0| 3| 8| 3| 3| 0| 3| 3| 0| 5| 3| 7| 7| 3| 4| 7| 3| 3| 4| 3| 3| 4| 5| 3| 3| |
| 8| 7| 0| 3| 3| 4| 6| 3| 2| 1| 3| 4| 8| 3| 2| 2| 6| 3| 8| 4| 4| 2| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + I + + + + + + + + + + +| 45 |
Degeneration, Hyaline | 2 | 1 2.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + M + A + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + A + + + M + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + A + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X | 1 |
Eosinophilic Focus | X 3 3 X X X | 7 3.0|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | 1 | 3 2.0|
Pigmentation | 3 | 1 3.0|
Bile Duct, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 6 |
Fat, Necrosis | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Atrophy | 1 | 1 1.0|
Cytoplasmic Alteration | 1 | 1 1.0|
Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mast Cell | | 1 4.0|
Ulcer | 1 1 | 3 1.3|
Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 2 1.5|
Infiltration Cellular, Mast Cell | | 1 4.0|
Inflammation, Suppurative | | 1 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 7| 5| 4| 7| 4| 5| 7| 7| 6| 7| 7| 4| 6| 7| 7| |
DAY ON TEST | 0| 3| 8| 3| 3| 0| 3| 3| 0| 5| 3| 7| 7| 3| 4| 7| 3| 3| 4| 3| 3| 4| 5| 3| 3| |
| 8| 7| 0| 3| 3| 4| 6| 3| 2| 1| 3| 4| 8| 3| 2| 2| 6| 3| 8| 4| 4| 2| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 | 17 1.0|
Hemorrhage | | 1 2.0|
Mineralization | 1 | 1 1.0|
Artery, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.5|
Hypertrophy | 1 1 3 | 3 1.7|
Necrosis | 4 | 1 4.0|
Capsule, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 | 4 1.3|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + + + + + M + + + M M + M I M + + + +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + M +| 47 |
Hyperplasia | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 2 4 4 1 4 3 2 2| 14 2.6|
Pars Intermedia, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Inflammation | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 1 2 1| 14 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + M + + + + + M + + + + + M + M + + M + +| 38 |
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Amyloid Deposition | | 1 2.0|
Angiectasis | 2 3 | 3 2.3|
Atrophy | 3 3 2 3 | 8 2.6|
Cyst | 2 3 1 3 2 2 2 1 | 19 2.1|
Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 7| 5| 4| 7| 4| 5| 7| 7| 6| 7| 7| 4| 6| 7| 7| |
DAY ON TEST | 0| 3| 8| 3| 3| 0| 3| 3| 0| 5| 3| 7| 7| 3| 4| 7| 3| 3| 4| 3| 3| 4| 5| 3| 3| |
| 8| 7| 0| 3| 3| 4| 6| 3| 2| 1| 3| 4| 8| 3| 2| 2| 6| 3| 8| 4| 4| 2| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Granulosa Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hydrometra | 1 | 3 2.3|
Hyperplasia, Cystic | 1 2 2 1 1 3 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2 2 3| 41 1.9|
Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hyperplasia, Histiocytic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
Iliac, Hyperplasia | 2 | 2 2.0|
Lumbar, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + M + + + M + M +| 36 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + M + +| 40 |
Hyperplasia | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M M + + + + + M + + + + + M + + + + +| 37 |
Hyperplasia | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 3 3 2 2 2 2 2 2 | 10 2.2|
Hyperplasia, Lymphoid | 2 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + M M + + + M + + M + M +| 40 |
Amyloid Deposition | | 1 4.0|
Atrophy | 3 | 5 3.4|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Subcutaneous Tissue, Edema | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 7| 5| 4| 7| 4| 5| 7| 7| 6| 7| 7| 4| 6| 7| 7| |
DAY ON TEST | 0| 3| 8| 3| 3| 0| 3| 3| 0| 5| 3| 7| 7| 3| 4| 7| 3| 3| 4| 3| 3| 4| 5| 3| 3| |
| 8| 7| 0| 3| 3| 4| 6| 3| 2| 1| 3| 4| 8| 3| 2| 2| 6| 3| 8| 4| 4| 2| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 2 2 1 2 1 1 1| 19 1.4|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 3 | 2 2.0|
Inflammation, Chronic, Focal | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 4 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 4.0|
Glomerulosclerosis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 1 1 1 1 2 2 1 1| 17 1.1|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 3| 3| 3| 3| 0| 3| 3|
| 3| 0| 4| 6| 4| 0| 0| 6| 7| 4| 3| 4| 3| 7| 8| 0| 6| 4| 4| 4| 6| 4| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + + + + A + + + M + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + M + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X |
Eosinophilic Focus | 3 X X X |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 |
Mixed Cell Focus | X X |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Cyst | 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | 1 3 |
Cytoplasmic Alteration | |
Hyperplasia | |
Hypertrophy | |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + A +|
Inflammation, Suppurative | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + I +|
Hyperplasia | 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 3| 3| 3| 3| 0| 3| 3|
| 3| 0| 4| 6| 4| 0| 0| 6| 7| 4| 3| 4| 3| 7| 8| 0| 6| 4| 4| 4| 6| 4| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + M M + M + M + + M M + + + + + + + + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 4 2|
Pars Intermedia, Hyperplasia | 3 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M M + + M + M + + M + + + + + + + M + + + + +|
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Cyst | 1 2 4 1 3 |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hydrometra | 1 3 |
Hyperplasia, Cystic | 2 1 3 1 3 1 3 1 2 2 2 2 2 1 2 3 2 2|
Thrombosis | 3 |
Endometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 4 |
__________________________________________________________________________|
Lymph Node | + + |
Degeneration, Cystic | 2 |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M M + M + + I M + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + I + + + + M + + + M + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + M + M + + + + I + M + + M M + + I + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mast Cell | 2 |
__________________________________________________________________________|
Thymus | + M + + + M + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 3| 3| 3| 3| 0| 3| 3|
| 3| 0| 4| 6| 4| 0| 0| 6| 7| 4| 3| 4| 3| 7| 8| 0| 6| 4| 4| 4| 6| 4| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 2 2 1 1 1 2 1 1 2|
Vertebra, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1|
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy, Focal | 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Amyloid Deposition | 4 |
Hydronephrosis | |
Hyperplasia, Lymphoid | 4 |
Metaplasia, Osseous | 1 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 3| 3| 3| 3| 0| 3| 3|
| 3| 0| 4| 6| 4| 0| 0| 6| 7| 4| 3| 4| 3| 7| 8| 0| 6| 4| 4| 4| 6| 4| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 3 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 4| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 6| 3| 5| 3| 3| 5| |
| 7| 3| 3| 7| 6| 9| 3| 6| 6| 4| 5| 3| 6| 3| 2| 6| 1| 3| 3| 0| 6| 2| 6| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + A + + + + + A + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + M + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A M + + + + A + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X X X | 9 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mixed Cell Focus | X | 3 |
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Bile Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Fat, Necrosis | 3 3 3 | 6 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 2 2.0|
Cytoplasmic Alteration | 1 | 1 1.0|
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 | 1 1.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 | 1 1.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 4| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 6| 3| 5| 3| 3| 5| |
| 7| 3| 3| 7| 6| 9| 3| 6| 6| 4| 5| 3| 6| 3| 2| 6| 1| 3| 3| 0| 6| 2| 6| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | 1 1 1 | 4 1.0|
Capsule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 2 2 1 3 | 8 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + + I + + M + M + M + + M + + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 1| 12 1.8|
Pars Intermedia, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 2 2 1 | 10 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + M + + + + + M + + M| 40 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 | 5 2.2|
Cyst | 2 2 2 3 2 1 2 2 3 1 | 15 2.1|
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Hydrometra | 3 3 3 | 5 2.6|
Hyperplasia, Cystic | 3 2 1 4 3 2 1 3 2 2 2 1 1 2 2 2 2 1 2 2 2 2 1| 41 2.0|
Thrombosis | | 1 3.0|
Endometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Degeneration, Cystic | | 1 2.0|
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + + + + + + + M + + + + + + M +| 41 |
Hyperplasia | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M + + + + + + + + + + + + M + + + + + + + +| 41 |
Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 4| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 6| 3| 5| 3| 3| 5| |
| 7| 3| 3| 7| 6| 9| 3| 6| 6| 4| 5| 3| 6| 3| 2| 6| 1| 3| 3| 0| 6| 2| 6| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + I + M + + + + + +| 46 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + M + + + + + + + + + M M + M M +| 36 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 2| 8 2.1|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + M + M + + + + + +| 44 |
Atrophy | 2 4 | 3 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 1 2 1 1 2 1 1 2 1 2 | 23 1.5|
Vertebra, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 2 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 3 1.7|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 4| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 6| 3| 5| 3| 3| 5| |
| 7| 3| 3| 7| 6| 9| 3| 6| 6| 4| 5| 3| 6| 3| 2| 6| 1| 3| 3| 0| 6| 2| 6| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Atrophy, Focal | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 4 | 2 4.0|
Hydronephrosis | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 4.0|
Metaplasia, Osseous | 1 1 | 3 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 | 17 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 7| 0| 5| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 1| 0| 3| 1| 2| 3| 3| 3| 2| 7| 3| 3| 3| 3| 3| 7| 3| 0| 6| 3| 0| 3|
| 7| 5| 4| 5| 6| 7| 0| 1| 7| 7| 4| 9| 4| 3| 7| 7| 9| 7| 0| 4| 2| 6| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + + M + + + M + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | |
Fat, Necrosis | 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + A +|
Atrophy | |
Hyperplasia | 2 1 |
Hypertrophy | 1 |
Inflammation | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Erosion | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 |
Artery, Inflammation | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hypertrophy | 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + M M + + M + + + + + M + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 7| 0| 5| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 1| 0| 3| 1| 2| 3| 3| 3| 2| 7| 3| 3| 3| 3| 3| 7| 3| 0| 6| 3| 0| 3|
| 7| 5| 4| 5| 6| 7| 0| 1| 7| 7| 4| 9| 4| 3| 7| 7| 9| 7| 0| 4| 2| 6| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + I +|
Pars Distalis, Hyperplasia | 2 3 2 2 3 2 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
Follicular Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + M + + + + + + M M + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 4 |
Cyst | 2 4 1 2 1 4 1 4 |
Inflammation | 4 |
Pigmentation, Hemosiderin | 4 |
Artery, Inflammation | 3 |
Corpus Luteum, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + A + + + +|
Angiectasis | 3 |
Hyperplasia, Cystic | 2 2 2 2 2 1 1 2 1 2 2 1 1 2 1 1 2 3 2 1 2 2|
Serosa, Cyst | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia | |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + M + + M + + + + + + M + M + + + + M +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M M + + + + + + M + + + M + + M + + + M|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A + + A +|
Angiectasis | |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + M + + + + + + + + + + + + + + + M|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hematopoietic Cell Proliferation | 2 2 3 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + M + + M + + I + M M + + + + + + + M + + + + M +|
Atrophy | 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 7| 0| 5| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 1| 0| 3| 1| 2| 3| 3| 3| 2| 7| 3| 3| 3| 3| 3| 7| 3| 0| 6| 3| 0| 3|
| 7| 5| 4| 5| 6| 7| 0| 1| 7| 7| 4| 9| 4| 3| 7| 7| 9| 7| 0| 4| 2| 6| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 1 1 2 2 1 1 1 2 |
Cranium, Fracture | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hydrocephalus | 2 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Spinal Cord | |
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 4 |
Inflammation, Chronic, Focal | 2 2 |
Alveolar Epithelium, Hyperplasia | 3 4 |
Mediastinum, Inflammation | 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + A +|
Inflammation, Suppurative | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Atrophy, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hydronephrosis | 2 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 2 1 1 1 1 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 7| 0| 5| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 1| 0| 3| 1| 2| 3| 3| 3| 2| 7| 3| 3| 3| 3| 3| 7| 3| 0| 6| 3| 0| 3|
| 7| 5| 4| 5| 6| 7| 0| 1| 7| 7| 4| 9| 4| 3| 7| 7| 9| 7| 0| 4| 2| 6| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + A +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| |
DAY ON TEST | 7| 9| 9| 3| 0| 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 2| 3| |
| 4| 9| 0| 3| 8| 4| 1| 4| 6| 7| 3| 9| 4| 6| 6| 6| 7| 4| 7| 3| 0| 4| 0| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Eosinophilic Focus | X 3 X X | 7 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Inflammation, Chronic | 4 | 1 4.0|
Fat, Necrosis | 4 4 | 4 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 | 1 2.0|
Hyperplasia | | 2 1.5|
Hypertrophy | | 1 1.0|
Inflammation | | 1 2.0|
Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Erosion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0|
Artery, Inflammation | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hypertrophy | 1 1 1 1 | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| |
DAY ON TEST | 7| 9| 9| 3| 0| 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 2| 3| |
| 4| 9| 0| 3| 8| 4| 1| 4| 6| 7| 3| 9| 4| 6| 6| 6| 7| 4| 7| 3| 0| 4| 0| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 4| 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + M M + + I M + + M + + + + + M + + + M +| 33 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 3 1 3 4 2 2 4 | 16 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 2 1 1 1 1 1 2 1 4 1 1 | 15 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M M + + + + + + + + + + + + + + + + + M +| 43 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 4 1 1 3 | 9 2.3|
Cyst | 2 2 2 1 1 3 | 14 2.1|
Inflammation | | 1 4.0|
Pigmentation, Hemosiderin | | 1 4.0|
Artery, Inflammation | | 1 3.0|
Corpus Luteum, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hyperplasia, Cystic | 1 3 1 2 1 2 3 2 1 1 1 2 1 1 1 2 1 1 2 4 1 1 | 44 1.6|
Serosa, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Iliac, Hyperplasia | 2 | 1 2.0|
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + I + + + + + + + M + M + + + + + + M + M + + + +| 39 |
Hyperplasia | 2 3 2 2| 6 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + M + M + I| 39 |
Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + I + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| |
DAY ON TEST | 7| 9| 9| 3| 0| 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 2| 3| |
| 4| 9| 0| 3| 8| 4| 1| 4| 6| 7| 3| 9| 4| 6| 6| 6| 7| 4| 7| 3| 0| 4| 0| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | 1 | 1 1.0|
Hyperplasia | 2 2| 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + + M + + + + M M + + + M M + +| 41 |
Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 | 10 2.2|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + M + + + + M + M + + + + + + + + + + M| 38 |
Atrophy | 1 2 | 3 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 2 3 2 2| 16 1.6|
Cranium, Fracture | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Hydrocephalus | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 1 4.0|
Inflammation, Chronic, Focal | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 2 3.5|
Mediastinum, Inflammation | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| |
DAY ON TEST | 7| 9| 9| 3| 0| 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 2| 3| |
| 4| 9| 0| 3| 8| 4| 1| 4| 6| 7| 3| 9| 4| 6| 6| 6| 7| 4| 7| 3| 0| 4| 0| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 2 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Olfactory Epithelium, Atrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | | 1 2.0|
Metaplasia, Osseous | 1 | 2 1.0|
Nephropathy | 1 1 1 1 1 1 1 | 19 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 6| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 2| 3| 3| 8| 3| 5| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7|
| 7| 4| 8| 4| 7| 2| 3| 8| 6| 1| 6| 6| 9| 4| 6| 3| 3| 4| 4| 3| 4| 3| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M A + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Diverticulum | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X |
Hematopoietic Cell Proliferation | 1 2 |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | |
Necrosis | 1 1 2 2 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | + + +|
Fat, Hemorrhage | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X |
Hyperplasia | 1 |
Hypertrophy | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
Angiectasis | |
Inflammation | |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Erosion | |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 6| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 2| 3| 3| 8| 3| 5| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7|
| 7| 4| 8| 4| 7| 2| 3| 8| 6| 1| 6| 6| 9| 4| 6| 3| 3| 4| 4| 3| 4| 3| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | |
Artery, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hypertrophy | 1 1 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + A + + + + + + + M + + + +|
Hyperplasia | 4 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + M + M M + M I + + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 3 2 2 2 2 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 2 3 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M I + + + + + + + + M + M + + + + + + + + + + I|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 3 2 2 2 3 |
Cyst | 2 2 1 3 2 1 2 1 2 2 |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 1 |
Angiectasis | 2 2 |
Hydrometra | 4 4 2 4 3|
Hyperplasia, Cystic | 4 2 2 2 2 2 2 2 1 1 1 2 1 2 1 2 2 1 2 |
Inflammation, Suppurative | 2 |
Thrombosis | 3 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 6| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 2| 3| 3| 8| 3| 5| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7|
| 7| 4| 8| 4| 7| 2| 3| 8| 6| 1| 6| 6| 9| 4| 6| 3| 3| 4| 4| 3| 4| 3| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | |
Lumbar, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + M + + + + + + + + + + M M + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + M + + M M + +|
Hyperplasia | 2 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + M M + M + + + + M + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 4|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arthrosis | 3 2 |
Fibrous Osteodystrophy | 3 2 1 3 1 2 2 2 1 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 3|
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 5| 7| 6| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 2| 3| 3| 8| 3| 5| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7|
| 7| 4| 8| 4| 7| 2| 3| 8| 6| 1| 6| 6| 9| 4| 6| 3| 3| 4| 4| 3| 4| 3| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 5| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 2| 3| 6| 7| 4| 3| 3| 9| |
| 2| 6| 3| 6| 4| 3| 0| 4| 7| 3| 7| 7| 9| 6| 3| 3| 6| 7| 3| 2| 7| 5| 6| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + A + + + + + + + + + + + + + + M + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + + + + + + + + + + + A + + M A| 44 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + A + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + A + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + A + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + A + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + A + + + A| 46 |
Diverticulum | X | 1 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + A + + + + + + + + + + + + + + + + + A + + + +| 48 |
Basophilic Focus | X | 1 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X | 11 |
Hematopoietic Cell Proliferation | 2 | 3 1.7|
Hepatodiaphragmatic Nodule | X | 1 |
Mixed Cell Focus | X | 1 |
Necrosis | 4 1 2 | 7 1.9|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Fat, Hemorrhage | 4 | 1 4.0|
Fat, Necrosis | 2 2 2 3 2 | 7 2.4|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + + + + + + + A + + + A| 46 |
Atrophy | 1 | 1 1.0|
Basophilic Focus | | 1 |
Hyperplasia | 2 | 2 1.5|
Hypertrophy | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + A + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + A + + + +| 47 |
Angiectasis | 2 | 1 2.0|
Inflammation | 1| 1 1.0|
Ulcer | 1 1 | 2 1.0|
Epithelium, Hyperplasia | 1| 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + A + + + +| 47 |
Erosion | 1 1 | 2 1.0|
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 5| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 2| 3| 6| 7| 4| 3| 3| 9| |
| 2| 6| 3| 6| 4| 3| 0| 4| 7| 3| 7| 7| 9| 6| 3| 3| 6| 7| 3| 2| 7| 5| 6| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + A + + + + + + + + + + + + + + + + + A + + + +| 48 |
Cardiomyopathy | 1 1 1 1 1 1 1 | 22 1.0|
Mineralization | 2 | 1 2.0|
Artery, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + M + + + + + + + + + + + + + + + + A + + + A| 46 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hypertrophy | 1 | 3 1.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + A + + + M| 45 |
Hyperplasia | | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + A + + + M| 46 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + A M M + + + + M M M + + + + + + + + + + + + A| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + A + + + + + + + + + + + + + + + + + A + + + +| 48 |
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 2 2 2 3 1 2 1 1 1 4 | 20 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + A + + + A| 47 |
C-Cell, Hyperplasia | | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 2 1 1 | 10 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + I M M + + + + + + + + + + + + A + + + +| 41 |
__________________________________________________________________________|____________|
Ovary | + + A + + + + + + + M + + + + + + + + + A + M + +| 46 |
Angiectasis | | 1 2.0|
Atrophy | 3 2 3 | 9 2.4|
Cyst | 4 3 1 2 4 2 1 | 17 2.1|
Interstitial Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Adenomyosis | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 5| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 2| 3| 6| 7| 4| 3| 3| 9| |
| 2| 6| 3| 6| 4| 3| 0| 4| 7| 3| 7| 7| 9| 6| 3| 3| 6| 7| 3| 2| 7| 5| 6| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | 2 | 3 2.0|
Hydrometra | 2 4 3 3 4 2 | 11 3.2|
Hyperplasia, Cystic | 3 2 1 2 2 2 1 2 2 2 3 2 1 2 2 2 2 3 1 2 1 3 | 41 1.9|
Inflammation, Suppurative | 2 | 2 2.0|
Thrombosis | | 1 3.0|
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + I A + + + A| 46 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Lumbar, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + A M + + + + + + + + + M + + + + + + + + + M M| 41 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + A + + M + + + + + M + + + + + + + + + + M + +| 41 |
Hyperplasia | 2 | 3 2.3|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A M + + + + + + + + + + + + + + + + A + + + A| 45 |
Hyperplasia | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + + + M + + + + + M + + + + + M M + + + M| 38 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + A + + + + + + + + + + + + + + + + + A + + + A| 46 |
Hematopoietic Cell Proliferation | 2 | 8 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | M + M + + + + M M + + + + + + + + + + + A + + + M| 44 |
Angiectasis | 2 | 1 2.0|
Atrophy | 1 | 2 2.5|
Hyperplasia, Lymphoid | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + I + + + + +| 49 |
Arthrosis | | 2 2.5|
Fibrous Osteodystrophy | 1 1 1 1 1 | 15 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 5| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 2| 3| 6| 7| 4| 3| 3| 9| |
| 2| 6| 3| 6| 4| 3| 0| 4| 7| 3| 7| 7| 9| 6| 3| 3| 6| 7| 3| 2| 7| 5| 6| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + A + + + + + + + + + + + + + + + + + A + + + A| 46 |
__________________________________________________________________________|____________|
Lung | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Histiocyte | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + + + + + + + + + + + A + + + A| 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + + + + + + + A + + + A| 46 |
Nephropathy | 1 1 3 1 | 13 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + A + M + A| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 1| 3| 3| 4| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 8| 3| 7| 5| 6| 3| 3|
| 0| 4| 6| 4| 9| 3| 7| 4| 4| 6| 7| 4| 0| 5| 6| 4| 6| 6| 2| 8| 8| 8| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Gallbladder | + + + + A + M + + + + + A + + + + + + M + + A M +|
Degeneration, Hyaline | |
Inflammation | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + M + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + + + + + + + A + + + + + + + + + A + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + A + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Congestion | |
Degeneration, Fatty, Focal | |
Eosinophilic Focus | X X X X X X X |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | |
Mixed Cell Focus | X |
Necrosis | 3 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + M + +|
Amyloid Deposition | |
Atrophy | |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + A + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + A + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + A + + + + + + + + + A + +|
Hyperplasia | 3 1 4 |
Hypertrophy | 1 1 1 1 2 3 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + A + + + + + + + + + A + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 1| 3| 3| 4| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 8| 3| 7| 5| 6| 3| 3|
| 0| 4| 6| 4| 9| 3| 7| 4| 4| 6| 7| 4| 0| 5| 6| 4| 6| 6| 2| 8| 8| 8| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + M + + M + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + A + +|
Pars Distalis, Cyst | 2 1 |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
Follicular Cell, Hyperplasia | 1 1 1 1 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Inflammation | 2 4 2 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + A + + + + + + + + + A + +|
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + A + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | 2|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + M M M + + + + + + M + M + M + + A + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + M + + + + + + + + + A + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + M + + M + M + M + M M + M + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + M + +|
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + + + M + + + + + + + + M + M + + + M + M A + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 1| 3| 3| 4| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 8| 3| 7| 5| 6| 3| 3|
| 0| 4| 6| 4| 9| 3| 7| 4| 4| 6| 7| 4| 0| 5| 6| 4| 6| 6| 2| 8| 8| 8| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | M + + + + + + + + + + + I + + + + + M + + + + + +|
Prepuce, Inflammation, Suppurative | 3 4 4 4 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + A + + + + + + + + + A + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + A + + + + + + + + + A + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Olfactory Epithelium, Atrophy, Focal | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Glomerulosclerosis | 2 |
Hydronephrosis | 2 |
Inflammation, Suppurative | 2 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + A + +|
Inflammation, Suppurative | 3 4 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 4| 5| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| |
| 1| 3| 7| 0| 4| 6| 3| 3| 4| 1| 4| 4| 7| 3| 8| 9| 3| 3| 2| 6| 6| 6| 4| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + A + + + + + + + + + + + +| 42 |
Degeneration, Hyaline | 2 | 1 2.0|
Inflammation | 1 | 1 1.0|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + A + + + + + + + + + + + M + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + A + + + + + + + + + + + +| 44 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + A + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + A + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Congestion | 3 2 | 2 2.5|
Degeneration, Fatty, Focal | 2 | 1 2.0|
Eosinophilic Focus | X X X X| 11 |
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Mixed Cell Focus | | 1 |
Necrosis | 2 4 1 1 2 4| 8 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | 1 | 1 1.0|
Atrophy | 1 | 1 1.0|
Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1| 28 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 4| 5| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| |
| 1| 3| 7| 0| 4| 6| 3| 3| 4| 1| 4| 4| 7| 3| 8| 9| 3| 3| 2| 6| 6| 6| 4| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 1 3 | 7 2.3|
Hypertrophy | 2 2 1 1 2 1 1 2 2 2 1 2 | 20 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 3 1 1 1 | 6 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + + + M + + + + M + + + I + + + M +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + I + + + + + M + M + + + +| 45 |
Pars Distalis, Cyst | 1 1 1 | 5 1.2|
Pars Distalis, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 2 2 1 1 1 2 1 | 16 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 2 | 5 2.4|
Inflammation | 3 2 3 | 8 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 | 3 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 4 | 5 2.2|
Interstitial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 2 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M M + + + M M + + + + M + + + M + + + M + +| 33 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M + + + + + + + + + + + + + + + M M + + + M| 42 |
Hyperplasia | 2 3 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 4| 5| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| |
| 1| 3| 7| 0| 4| 6| 3| 3| 4| 1| 4| 4| 7| 3| 8| 9| 3| 3| 2| 6| 6| 6| 4| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | 2 4 | 2 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hyperplasia | 3 2 2| 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + M + M + M + + + M + +| 36 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 | 9 1.9|
Hyperplasia, Lymphoid | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Thymus | M + I + + + + + M + + M + + M + + + + + + + M M M| 35 |
Atrophy | 2 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Prepuce, Inflammation, Suppurative | 4 4 | 7 3.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 3 1.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 3 2 4 | 5 2.6|
Alveolar Epithelium, Hyperplasia | 2 1 2 2| 6 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 | 3 1.3|
Olfactory Epithelium, Atrophy, Focal | 1| 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 4| 5| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| |
| 1| 3| 7| 0| 4| 6| 3| 3| 4| 1| 4| 4| 7| 3| 8| 9| 3| 3| 2| 6| 6| 6| 4| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Glomerulosclerosis | 4 | 2 3.0|
Hydronephrosis | 2 1 | 3 1.7|
Inflammation, Suppurative | 1 | 3 1.3|
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 3 1 2 1 2 1| 31 1.2|
Cortex, Cyst | 2 1 | 2 1.5|
Renal Tubule, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 4 | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 5| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 0| 3| 4| 3| 2| 3| 3| 3| 3| 3| 7| 2| 3| 4|
| 4| 7| 4| 5| 3| 6| 6| 4| 6| 6| 6| 6| 6| 1| 7| 4| 4| 7| 6| 6| 4| 7| 6| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + A + + + + + A + + +|
Degeneration, Hyaline | |
Inflammation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + A + + M M + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + A + + + + + A + + +|
Ulcer | 2|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + A + + + + + A + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + A + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X X 3 X X |
Hematopoietic Cell Proliferation | |
Mixed Cell Focus | X |
Necrosis | 4 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + A + + +|
Atrophy | 1 |
Hypertrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + A + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 4 |
Hypertrophy | 2 4 1 1 1 1 2 2 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + A + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M + + + M + + + + + M + + M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 5| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 0| 3| 4| 3| 2| 3| 3| 3| 3| 3| 7| 2| 3| 4|
| 4| 7| 4| 5| 3| 6| 6| 4| 6| 6| 6| 6| 6| 1| 7| 4| 4| 7| 6| 6| 4| 7| 6| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 3 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation | 2 |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation | 3 4 4 3 3 4 4 3 4 4 |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Prostate | + + M + + + M + + + + + + + M + + M M + M + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + A + + + + + A + + +|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia | |
Renal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M M M + + + + + + M + + + + M M + M + M M|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + M + + M + M + M + + M + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + + A + + +|
Angiectasis | |
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + M + M + + + + + + + M M|
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hematopoietic Cell Proliferation | 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 5| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 0| 3| 4| 3| 2| 3| 3| 3| 3| 3| 7| 2| 3| 4|
| 4| 7| 4| 5| 3| 6| 6| 4| 6| 6| 6| 6| 6| 1| 7| 4| 4| 7| 6| 6| 4| 7| 6| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M M M + + + I + + + + M + + + M M + + M|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M + M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Prepuce, Inflammation, Suppurative | 4 4 2|
Subcutaneous Tissue, Infiltration | |
Cellular, Mast Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + A + + + + + + + + +|
Epiglottis, Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 3 3 2 3 |
Inflammation, Chronic, Focal | 2 2 |
Pigmentation, Hemosiderin | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Atrophy, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + A + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 5| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 0| 3| 4| 3| 2| 3| 3| 3| 3| 3| 7| 2| 3| 4|
| 4| 7| 4| 5| 3| 6| 6| 4| 6| 6| 6| 6| 6| 1| 7| 4| 4| 7| 6| 6| 4| 7| 6| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 3 2 1 2 1 1 1 1 4|
Cortex, Cyst | 1 |
Renal Tubule, Hyperplasia | 1 1 |
__________________________________________________________________________|
Ureter | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
Calculus Micro Observation Only | |
Inflammation, Suppurative | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 3| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 4| 3| 9| 1| 1| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 3| 3| 3| 4| 3| |
| 3| 7| 4| 4| 4| 4| 3| 4| 4| 4| 6| 8| 4| 2| 4| 7| 7| 3| 4| 5| 3| 6| 7| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 46 |
Degeneration, Hyaline | 2 | 1 2.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + A + + + + + +| 45 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + A + + + + + +| 45 |
Peyer's Patch, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | X X X | 8 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis | 2 4 2 2 | 5 2.8|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 1 4 2 | 4 2.0|
Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Epithelium, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 5 2.8|
Hypertrophy | 2 1 1 1 2 2 2 1 2 2 2 1 1| 24 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 3| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 4| 3| 9| 1| 1| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 3| 3| 3| 4| 3| |
| 3| 7| 4| 4| 4| 4| 3| 4| 4| 4| 6| 8| 4| 2| 4| 7| 7| 3| 4| 5| 3| 6| 7| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + M + + + M + I M I + + M + + + + + M M| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 2 1 1 1 | 12 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 1 2.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + + | 2 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Cyst | 2 3 | 3 3.0|
Inflammation | 2 4 3 4 4 3| 16 3.5|
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +| 43 |
Inflammation, Suppurative | 2 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 3 2.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 2 3 2 | 6 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + | 4 |
Iliac, Hyperplasia | 2 3 4 | 3 3.0|
Renal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + + + + M M + M + + + + + M M + + + M + +| 32 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + M + + + + + + + + + + + M +| 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 3| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 4| 3| 9| 1| 1| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 3| 3| 3| 4| 3| |
| 3| 7| 4| 4| 4| 4| 3| 4| 4| 4| 6| 8| 4| 2| 4| 7| 7| 3| 4| 5| 3| 6| 7| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 1 2.0|
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + M + + + + + + + + + + M I + + + M +| 40 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 3 | 13 2.1|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | M + + M M + I + + + + + + + M + + + + + + + + + +| 37 |
Atrophy | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 4.0|
Prepuce, Inflammation, Suppurative | 4 4 4 4 | 7 3.7|
Subcutaneous Tissue, Infiltration | | |
Cellular, Mast Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 2 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epiglottis, Metaplasia, Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 2 2 | 7 2.6|
Inflammation, Chronic, Focal | | 2 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 3| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 4| 3| 9| 1| 1| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 3| 3| 3| 4| 3| |
| 3| 7| 4| 4| 4| 4| 3| 4| 4| 4| 6| 8| 4| 2| 4| 7| 7| 3| 4| 5| 3| 6| 7| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mononuclear Cell | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 3 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Olfactory Epithelium, Atrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 2 2 1 | 3 1.7|
Inflammation, Suppurative | 1 2 2 2 | 5 1.8|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 2 2 3 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.3|
Cortex, Cyst | | 1 1.0|
Renal Tubule, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + + | 3 |
Inflammation, Suppurative | 2 4 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Micro Observation Only | X | 1 |
Inflammation, Suppurative | 4 4 4 1 3 | 6 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 6| 3| 3| 1| 9| 3| 3| 3| 5| 3| 5| 6|
| 6| 4| 3| 4| 7| 4| 1| 6| 3| 8| 4| 4| 6| 6| 6| 4| 2| 4| 4| 4| 7| 1| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + A M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Peyer's Patch, Hyperplasia | 4 |
Peyer's Patch, Inflammation | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X 3 X X X X X |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 |
Necrosis | 4 4 1 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Erosion | 3 |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation | 2 |
Aorta, Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1|
Hyperplasia, Atypical | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hemorrhage | |
Hyperplasia | 1 1 4 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 6| 3| 3| 1| 9| 3| 3| 3| 5| 3| 5| 6|
| 6| 4| 3| 4| 7| 4| 1| 6| 3| 8| 4| 4| 6| 6| 6| 4| 2| 4| 4| 4| 7| 1| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 1 2 1 1 1 2 1 1 2 |
Capsule, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + M + + + M + + + + M I M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + M|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Follicular Cell, Hyperplasia | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation | 1 2 4 2 |
__________________________________________________________________________|
Prostate | + M + + + + M + + M + + + + + + + + + + + A + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + A + + +|
Angiectasis | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + M + + M M + + + M + M M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + M + + M + + + I + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + I + + + + + + + + + + + A + + +|
Angiectasis | 1|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 6| 3| 3| 1| 9| 3| 3| 3| 5| 3| 5| 6|
| 6| 4| 3| 4| 7| 4| 1| 6| 3| 8| 4| 4| 6| 6| 6| 4| 2| 4| 4| 4| 7| 1| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 3 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M I + M + + M + + M + + + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + M + M + + + + M M M + + + + + M M|
Atrophy | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 2 |
Prepuce, Inflammation, Suppurative | 4 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Synovial Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + A + + +|
Epiglottis, Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 4 1 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Suppurative | 1 1 |
Olfactory Epithelium, Atrophy, Focal | 3 3 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 3| 6| 3| 3| 1| 9| 3| 3| 3| 5| 3| 5| 6|
| 6| 4| 3| 4| 7| 4| 1| 6| 3| 8| 4| 4| 6| 6| 6| 4| 2| 4| 4| 4| 7| 1| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | 2 2 3 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | 1 |
Mineralization | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3|
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Suppurative | 4 4 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 7| 3| 7| 5| 7| 5| 5| 7| 4| 5| 5| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 2| 3| 0| 3| 7| 3| 6| 3| 9| 7| 3| 4| 9| 5| 7| 3| 3| 8| 3| 3| 3| |
| 3| 6| 3| 4| 1| 4| 4| 4| 6| 6| 0| 3| 5| 4| 6| 0| 4| 4| 4| 7| 4| 2| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + A + + + + + + A + + I + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + A + + + + + + A + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + A + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + A + + + + + + A + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + + A + + + + + + + + +| 46 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + A + + + + + + A + + + + + + + + +| 46 |
Peyer's Patch, Hyperplasia | | 1 4.0|
Peyer's Patch, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X 3 X| 10 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | 1 4 | 6 2.8|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + A + + + + I + A + + + + + + + + +| 46 |
Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A + + + + + + A + + + + + + + + +| 48 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + A + + + + + + A + + + + + + + + +| 46 |
Erosion | | 1 3.0|
Infiltration Cellular, Mast Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Inflammation | | 1 2.0|
Aorta, Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.1|
Hyperplasia, Atypical | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 7| 3| 7| 5| 7| 5| 5| 7| 4| 5| 5| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 2| 3| 0| 3| 7| 3| 6| 3| 9| 7| 3| 4| 9| 5| 7| 3| 3| 8| 3| 3| 3| |
| 3| 6| 3| 4| 1| 4| 4| 4| 6| 6| 0| 3| 5| 4| 6| 0| 4| 4| 4| 7| 4| 2| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia | 2 2 | 6 2.0|
Hypertrophy | 1 1 2 2 2 1 1 1 1 1| 19 1.3|
Capsule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + A + + + + M + A + + + + + + + + +| 46 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + + + M M + M + + M + + M + M M M M + + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + A + + + + + + A + + + + + + + + +| 45 |
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 | 9 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 4 | 1 4.0|
__________________________________________________________________________|____________|
Penis | + + | 2 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Inflammation | 3 3 4 3 3 | 9 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + M + + + A + + + + + + + + + + + + + + + +| 44 |
Inflammation, Suppurative | 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + A + + + + A + + + + + + A + + + + + + + + +| 46 |
Angiectasis | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 7| 3| 7| 5| 7| 5| 5| 7| 4| 5| 5| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 2| 3| 0| 3| 7| 3| 6| 3| 9| 7| 3| 4| 9| 5| 7| 3| 3| 8| 3| 3| 3| |
| 3| 6| 3| 4| 1| 4| 4| 4| 6| 6| 0| 3| 5| 4| 6| 0| 4| 4| 4| 7| 4| 2| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 4 | 7 2.6|
Infiltration Cellular, Mast Cell | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + | 4 |
Iliac, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + M + M + + + M + + + M + M + + M + + +| 36 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M M + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + + + + A + + + + + + + + + + + + + + + +| 46 |
Angiectasis | | 1 1.0|
Hyperplasia | 2 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + + + + + + + + + M + + + + M + + M + + +| 39 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + + + + + + A + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 | 14 2.0|
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + A M + + + M M + M + + M + M + I + + + + + +| 34 |
Atrophy | 2 1 4 3 | 4 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + M M + + + + +| 48 |
Inflammation, Suppurative | | 2 3.0|
Prepuce, Inflammation, Suppurative | 4 4 4 1 | 7 3.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 | 2 1.0|
Synovial Tissue, Inflammation, | | |
Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Epiglottis, Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 7| 3| 7| 5| 7| 5| 5| 7| 4| 5| 5| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 2| 3| 0| 3| 7| 3| 6| 3| 9| 7| 3| 4| 9| 5| 7| 3| 3| 8| 3| 3| 3| |
| 3| 6| 3| 4| 1| 4| 4| 4| 6| 6| 0| 3| 5| 4| 6| 0| 4| 4| 4| 7| 4| 2| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | 4 4 3 3 | 7 3.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Inflammation, Suppurative | | 2 1.0|
Olfactory Epithelium, Atrophy, Focal | 2 | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 2 2 | 5 2.2|
Inflammation, Suppurative | 2 1 3 2 | 5 2.0|
Metaplasia, Osseous | 1 | 2 1.0|
Mineralization | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2| 33 1.1|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + A + + + + + + A + + + + + + + + +| 46 |
Inflammation, Suppurative | 3 4 4 4 | 6 3.8|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 2| 2| 7| 2| 2| 1| 4| 3| 7| 2| 7| 2| 5| 3| 7| 7| 6| 2| 1| 6| 3| 7| 1| 7| 3|
DAY ON TEST | 4| 2| 2| 3| 6| 9| 1| 5| 3| 4| 3| 7| 2| 1| 3| 3| 8| 7| 0| 5| 5| 3| 8| 3| 4|
| 0| 9| 1| 9| 0| 1| 4| 9| 3| 5| 6| 5| 7| 3| 6| 6| 7| 5| 2| 8| 9| 4| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + A + + + + A + A + A + + A + + + + M A + A|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + M + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + A + + + A + + + + M + + + A + A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A + + + + A + A + A + + A + + + + + A + A|
Muscularis, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + A + + + + + A + A + M + + A + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A A + + + + A + A A A + + A + A + + + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + + + A + A + A + + A + A + + + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Necrosis | 2 1 1 |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy | |
Hypertrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + A|
Degeneration, Hyaline | 2 |
Erosion | 4 2 |
Inflammation, Suppurative | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 2 1 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + + M M + M M M + + + M + + M M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 2| 2| 7| 2| 2| 1| 4| 3| 7| 2| 7| 2| 5| 3| 7| 7| 6| 2| 1| 6| 3| 7| 1| 7| 3|
DAY ON TEST | 4| 2| 2| 3| 6| 9| 1| 5| 3| 4| 3| 7| 2| 1| 3| 3| 8| 7| 0| 5| 5| 3| 8| 3| 4|
| 0| 9| 1| 9| 0| 1| 4| 9| 3| 5| 6| 5| 7| 3| 6| 6| 7| 5| 2| 8| 9| 4| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Penis | + + + + + + + + + + + + + +|
Congestion | 4 |
Inflammation, Suppurative | 2 4 1 3 1 2|
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + A + +|
Cyst | 2 |
Inflammation | 3 2 2 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + M|
Inflammation, Suppurative | 3 3 3 2 2 1 3 2 2 2 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + A + + + + + + + A + + + + + + + + + + + + A + A|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 4 2 3 3 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia | 3 2 2 3 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M M M + M + + + M + M + M + M M + + M + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | M M I + M + + + + + M M + M M + + M M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + M M + + + + M + + M + + + + + M + + + + + A|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + + + M + M + M + + M + M + M M + + +|
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 2 2 4 2 2 2 2 3 3 2 3 2 2 |
__________________________________________________________________________|
Thymus | + M + M + + M + + + + + M M I + + + + M + + M M +|
Atrophy | 2 2 1 2 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Suppurative | 4 1 4 2 3 4 4 4 4 1 2 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
_____________________________________________________________________________________________________________________
| 2| 2| 7| 2| 2| 1| 4| 3| 7| 2| 7| 2| 5| 3| 7| 7| 6| 2| 1| 6| 3| 7| 1| 7| 3|
DAY ON TEST | 4| 2| 2| 3| 6| 9| 1| 5| 3| 4| 3| 7| 2| 1| 3| 3| 8| 7| 0| 5| 5| 3| 8| 3| 4|
| 0| 9| 1| 9| 0| 1| 4| 9| 3| 5| 6| 5| 7| 3| 6| 6| 7| 5| 2| 8| 9| 4| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
Olfactory Epithelium, Atrophy, Focal | |
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 2 2 1 2 1 2 2 2|
Inflammation, Suppurative | 1 3 4 2 3 2 1 1 3 3 3 3 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 |
Cortex, Cyst | |
Pelvis, Necrosis | 3 2 |
Renal Tubule, Hypertrophy | 1 |
Renal Tubule, Necrosis | 2 1 |
__________________________________________________________________________|
Urethra | + + + + + + + + + +|
Inflammation, Suppurative | 1 4 2 2 2 3 2 2 4 1|
Necrosis | 4 2 4 2|
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + A + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X X |
Inflammation, Suppurative | 4 3 3 4 3 2 3 3 3 1 2 |
Transitional Epithelium, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 7| 3| 7| 7| 6| 1| 7| 7| 7| 3| 0| 2| 3| 7| 5| 3| 0| 3| 6| 3| 3| 2| |
DAY ON TEST | 5| 1| 5| 3| 5| 3| 3| 7| 9| 0| 3| 3| 8| 9| 7| 2| 3| 5| 5| 0| 3| 3| 5| 4| 6| |
| 9| 5| 2| 4| 9| 6| 6| 0| 0| 6| 3| 4| 6| 9| 3| 1| 3| 4| 9| 7| 5| 9| 9| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + M + + + + + A + + + + + + + + + + +| 38 |
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + M + + + + + + + + + + + M + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + A + + + + + + + + + + +| 40 |
Muscularis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + + + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X | 5 |
Necrosis | 1 | 4 1.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 1 | 1 1.0|
Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration, Hyaline | | 1 2.0|
Erosion | 2 | 3 2.7|
Inflammation, Suppurative | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 | 14 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
Hypertrophy | 2 2 1 1 1 3 2 | 10 1.6|
Capsule, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 7| 3| 7| 7| 6| 1| 7| 7| 7| 3| 0| 2| 3| 7| 5| 3| 0| 3| 6| 3| 3| 2| |
DAY ON TEST | 5| 1| 5| 3| 5| 3| 3| 7| 9| 0| 3| 3| 8| 9| 7| 2| 3| 5| 5| 0| 3| 3| 5| 4| 6| |
| 9| 5| 2| 4| 9| 6| 6| 0| 0| 6| 3| 4| 6| 9| 3| 1| 3| 4| 9| 7| 5| 9| 9| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M I M + + + M + + M + + + M M + + M + M + + + + +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + + M + +| 47 |
Pars Distalis, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Penis | + + + + + + + + + + + + +| 27 |
Congestion | | 1 4.0|
Inflammation, Suppurative | 1 3 4 | 9 2.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 2.0|
Inflammation | 1 2 3 4 | 9 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Inflammation, Suppurative | 2 1 | 14 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 1 2 2 2 | 14 2.6|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Iliac, Hyperplasia | | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + M + + M + M + + M M + + + M M M M + + M| 26 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M + + M + + + + + + M + M + + + + + + +| 35 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + M + + + +| 41 |
Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M M + + + + + + M + + + + + + M M M + + M M| 32 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 7| 3| 7| 7| 6| 1| 7| 7| 7| 3| 0| 2| 3| 7| 5| 3| 0| 3| 6| 3| 3| 2| |
DAY ON TEST | 5| 1| 5| 3| 5| 3| 3| 7| 9| 0| 3| 3| 8| 9| 7| 2| 3| 5| 5| 0| 3| 3| 5| 4| 6| |
| 9| 5| 2| 4| 9| 6| 6| 0| 0| 6| 3| 4| 6| 9| 3| 1| 3| 4| 9| 7| 5| 9| 9| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 2 2 2 | 18 2.3|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + M M + + + + M + + + + + + + I + +| 36 |
Atrophy | 4 2 | 9 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Suppurative | 4 4 4 4 4 1 | 18 3.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 4 | 1 4.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 4 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.5|
Olfactory Epithelium, Atrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 2 2 2 1 1 1 1 3 3| 18 1.8|
Inflammation, Suppurative | 3 2 4 1 4 2 | 18 2.5|
Metaplasia, Osseous | 1 1 | 3 1.0|
Nephropathy | 1 1 2 1 2 1 1 1 3 1 | 14 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05181-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:49:30
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 7| 3| 7| 7| 6| 1| 7| 7| 7| 3| 0| 2| 3| 7| 5| 3| 0| 3| 6| 3| 3| 2| |
DAY ON TEST | 5| 1| 5| 3| 5| 3| 3| 7| 9| 0| 3| 3| 8| 9| 7| 2| 3| 5| 5| 0| 3| 3| 5| 4| 6| |
| 9| 5| 2| 4| 9| 6| 6| 0| 0| 6| 3| 4| 6| 9| 3| 1| 3| 4| 9| 7| 5| 9| 9| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Cyst | 1 | 1 1.0|
Pelvis, Necrosis | 1| 3 2.0|
Renal Tubule, Hypertrophy | | 1 1.0|
Renal Tubule, Necrosis | | 2 1.5|
__________________________________________________________________________|____________|
Urethra | + + + +| 14 |
Inflammation, Suppurative | 1 3| 12 2.3|
Necrosis | 3| 5 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Calculus Gross Observation | X | 3 |
Calculus Micro Observation Only | | 2 |
Inflammation, Suppurative | 4 4 3 2 1 | 16 2.8|
Transitional Epithelium, Hyperplasia | 2 2 4 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
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---------- END OF REPORT ----------
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