TDMS Study 05181-03 Pathology Tables
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0109-99-9
Lock Date: 03/24/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 18 22 19 19
Natural Death 7 3 5 5
Survivors
Terminal Sacrifice 25 25 26 26
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (49) (49) (46)
Parasite Metazoan 1 (2%) 1 (2%) 5 (10%) 7 (15%)
Intestine Large, Rectum (48) (50) (50) (47)
Parasite Metazoan 6 (13%) 2 (4%) 6 (12%) 5 (11%)
Intestine Large, Cecum (47) (49) (46) (45)
Parasite Metazoan 2 (4%) 3 (6%) 4 (9%) 7 (16%)
Ulcer 1 (2%)
Intestine Small, Ileum (45) (49) (46) (45)
Parasite Metazoan 1 (2%)
Liver (50) (49) (50) (50)
Angiectasis 3 (6%) 4 (8%) 1 (2%)
Basophilic Focus 6 (12%) 2 (4%) 6 (12%)
Clear Cell Focus 6 (12%) 7 (14%) 6 (12%)
Degeneration, Cystic 2 (4%) 2 (4%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 6 (12%) 5 (10%) 3 (6%) 10 (20%)
Hyperplasia, Reticulum Cell 2 (4%)
Inflammation, Granulomatous 2 (4%)
Vacuolization Cytoplasmic 7 (14%) 16 (33%) 12 (24%) 3 (6%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Necrosis 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Hepatocyte, Regeneration 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (6) (9) (9) (3)
Fat, Inflammation, Granulomatous 2 (33%) 1 (33%)
Fat, Mineralization 1 (11%)
Fat, Necrosis 4 (67%) 8 (89%) 7 (78%) 2 (67%)
Oral Mucosa (1)
Hyperplasia 1 (100%)
Pancreas (48) (50) (50) (49)
Atrophy 3 (6%) 6 (12%) 4 (8%) 7 (14%)
Stomach, Forestomach (49) (49) (50) (49)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 6 (12%) 7 (14%) 3 (6%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Suppurative 1 (2%) 3 (6%) 2 (4%)
Necrosis 1 (2%)
Ulcer 2 (4%) 5 (10%) 1 (2%) 2 (4%)
Stomach, Glandular (49) (49) (50) (49)
Mineralization 1 (2%) 1 (2%)
Necrosis 1 (2%)
Ulcer 2 (4%) 2 (4%)
Tooth (1)
Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Thrombosis 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 1 (2%) 1 (2%)
Atrium, Thrombosis 2 (4%) 1 (2%) 1 (2%)
Endocardium, Hemorrhage 1 (2%)
Endocardium, Atrium, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 6 (12%) 10 (20%) 7 (14%) 11 (22%)
Zona Reticularis, Pigmentation 1 (2%)
Adrenal Medulla (50) (50) (49) (50)
Hemorrhage 1 (2%)
Hyperplasia 4 (8%) 2 (4%) 9 (18%) 6 (12%)
Necrosis 1 (2%)
Islets, Pancreatic (48) (50) (50) (49)
Hyperplasia 1 (2%)
Parathyroid Gland (43) (43) (46) (42)
Hyperplasia 1 (2%) 2 (5%)
Pituitary Gland (49) (49) (50) (50)
Cyst 9 (18%) 6 (12%) 4 (8%) 6 (12%)
Hemorrhage 2 (4%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 5 (10%) 3 (6%) 6 (12%) 2 (4%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (48) (50) (50) (49)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 5 (10%) 6 (12%) 7 (14%) 10 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (48) (46) (49)
Cyst 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 4 (8%) 3 (7%) 1 (2%)
Inflammation, Chronic 2 (4%) 3 (6%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 2 (4%) 3 (6%) 3 (7%) 2 (4%)
Ovary (50) (50) (50) (50)
Cyst 9 (18%) 3 (6%) 5 (10%) 4 (8%)
Bilateral, Cyst 1 (2%)
Uterus (50) (50) (50) (50)
Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Hyperplasia, Reticulum Cell 3 (6%) 1 (2%) 1 (2%)
Myelofibrosis 1 (2%) 2 (4%)
Lymph Node (7) (7) (6) (5)
Iliac, Hyperplasia, Histiocytic 1 (14%)
Iliac, Hyperplasia, Lymphoid 2 (29%)
Iliac, Pigmentation 1 (14%)
Lumbar, Pigmentation 1 (14%)
Pancreatic, Pigmentation 1 (14%)
Renal, Hyperplasia, Lymphoid 2 (29%)
Lymph Node, Bronchial (46) (45) (41) (45)
Hemorrhage 1 (2%) 1 (2%)
Lymph Node, Mandibular (45) (47) (48) (44)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mesenteric (48) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Lymph Node, Mediastinal (48) (48) (48) (46)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Suppurative 1 (2%)
Pigmentation 1 (2%)
Spleen (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Accessory Spleen 1 (2%)
Angiectasis 1 (2%)
Fibrosis 1 (2%) 1 (2%) 3 (6%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%) 1 (2%)
Hemorrhage 2 (4%) 3 (6%) 1 (2%)
Necrosis 2 (4%) 1 (2%) 2 (4%)
Pigmentation 1 (2%)
Thymus (50) (50) (49) (48)
Cyst 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 3 (6%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Suppurative 1 (2%)
Duct, Dilatation 1 (2%)
Duct, Metaplasia, Squamous 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Skin (50) (50) (50) (50)
Hyperkeratosis 3 (6%)
Hyperplasia 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 2 (4%) 3 (6%) 1 (2%)
Epidermis, Cyst 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrosis 1 (2%)
Cartilage, Sternum, Degeneration, Mucoid 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Gliosis 1 (2%)
Hemorrhage 6 (12%) 3 (6%) 5 (10%) 5 (10%)
Necrosis 1 (2%)
Meninges, Hyperplasia 1 (2%)
Ventricle, Hydrocephalus 5 (10%) 8 (16%) 8 (16%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (48) (48)
Foreign Body 6 (12%) 2 (4%) 6 (13%) 7 (15%)
Inflammation, Suppurative 3 (6%) 1 (2%) 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%) 1 (2%)
Epithelium, Hyperplasia 3 (6%) 3 (6%) 3 (6%) 8 (17%)
Epithelium, Metaplasia, Squamous 2 (4%) 1 (2%) 2 (4%) 5 (10%)
Glands, Inflammation, Suppurative 3 (6%) 1 (2%) 1 (2%)
Lung (50) (50) (49) (50)
Hemorrhage 8 (16%) 15 (30%) 11 (22%) 10 (20%)
Inflammation, Granulomatous 1 (2%)
Alveolar Epithelium, Fibrosis 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%) 1 (2%)
Alveolar Epithelium, Infiltration Cellular,
Histiocyte 5 (10%) 3 (6%) 4 (8%) 2 (4%)
Alveolar Epithelium, Pigmentation 1 (2%)
Nose (49) (49) (50) (49)
Foreign Body 1 (2%) 3 (6%) 3 (6%) 2 (4%)
Inflammation, Suppurative 2 (4%) 4 (8%) 4 (8%) 3 (6%)
Goblet Cell, Respiratory Epithelium,
Hypertrophy 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 2 (4%) 1 (2%)
Nasopharyngeal Duct, Hyperplasia 1 (2%)
Olfactory Epithelium, Metaplasia 1 (2%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (3) (1) (3)
Atrophy 1 (33%)
Cataract 1 (33%) 2 (67%) 1 (100%) 2 (67%)
Bilateral, Cataract 1 (33%)
Cornea, Hyperplasia 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 2 (4%) 1 (2%)
Nephropathy, Chronic 48 (96%) 44 (88%) 43 (86%) 42 (84%)
Cortex, Necrosis 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Degeneration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Mineralization 47 (94%) 46 (92%) 50 (100%) 46 (92%)
Renal Tubule, Pigmentation 1 (2%)
Urinary Bladder (49) (50) (50) (49)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 31 39 40 34
Natural Death 6 4 5 10
Accidently Killed 1 1
Survivors
Terminal Sacrifice 12 6 5 6
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (48) (48) (45)
Parasite Metazoan 3 (6%) 6 (13%) 4 (8%) 5 (11%)
Muscularis, Mineralization 1 (2%)
Intestine Large, Rectum (49) (49) (48) (48)
Parasite Metazoan 1 (2%) 3 (6%) 2 (4%) 4 (8%)
Intestine Large, Cecum (49) (48) (48) (46)
Necrosis 1 (2%)
Parasite Metazoan 4 (8%) 3 (6%) 4 (8%) 6 (13%)
Ulcer 1 (2%)
Artery, Inflammation, Granulomatous 1 (2%)
Intestine Small, Ileum (47) (47) (47) (44)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 6 (12%) 3 (6%) 4 (8%)
Basophilic Focus 1 (2%) 1 (2%) 2 (4%)
Clear Cell Focus 2 (4%) 2 (4%) 1 (2%)
Degeneration, Cystic 9 (18%) 6 (12%) 9 (18%) 13 (26%)
Eosinophilic Focus 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 2 (4%) 5 (10%)
Hyperplasia, Reticulum Cell 1 (2%)
Inflammation, Granulomatous 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 3 (6%) 7 (14%) 3 (6%)
Bile Duct, Hyperplasia 7 (14%) 7 (14%) 6 (12%) 6 (12%)
Hepatocyte, Necrosis 3 (6%) 2 (4%) 2 (4%) 5 (10%)
Hepatocyte, Regeneration 1 (2%)
Periportal, Fibrosis 1 (2%) 1 (2%)
Serosa, Fibrosis 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Mesentery (15) (17) (18) (10)
Artery, Inflammation, Chronic 1 (7%)
Fat, Hemorrhage 3 (20%) 1 (10%)
Fat, Inflammation, Granulomatous 5 (33%) 1 (6%) 2 (11%)
Fat, Mineralization 1 (6%) 2 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 8 (53%) 15 (88%) 12 (67%) 9 (90%)
Oral Mucosa (3) (1)
Hyperplasia 1 (33%)
Inflammation, Suppurative 1 (33%)
Ulcer 1 (33%)
Gingival, Cyst 1 (33%)
Gingival, Foreign Body 1 (33%)
Pancreas (50) (50) (50) (50)
Atrophy 18 (36%) 11 (22%) 7 (14%) 17 (34%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Artery, Inflammation, Granulomatous 1 (2%)
Stomach, Forestomach (50) (49) (49) (50)
Diverticulum 1 (2%) 1 (2%)
Hyperkeratosis 5 (10%) 2 (4%) 3 (6%) 5 (10%)
Hyperplasia 10 (20%) 14 (29%) 8 (16%) 11 (22%)
Inflammation, Suppurative 3 (6%) 1 (2%) 3 (6%) 1 (2%)
Mineralization 2 (4%) 2 (4%) 2 (4%)
Necrosis 1 (2%) 1 (2%)
Ulcer 6 (12%) 10 (20%) 3 (6%) 6 (12%)
Stomach, Glandular (50) (50) (50) (50)
Edema 1 (2%)
Inflammation, Suppurative 2 (4%)
Metaplasia, Squamous 1 (2%)
Mineralization 7 (14%) 1 (2%) 7 (14%) 5 (10%)
Ulcer 1 (2%) 2 (4%) 1 (2%)
Tooth (2) (1) (2)
Developmental Malformation 1 (50%) 1 (100%)
Inflammation, Suppurative 1 (50%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (43) (50) (49) (44)
Mineralization 3 (7%) 4 (8%) 2 (5%)
Thrombosis 1 (2%)
Aorta, Mineralization 1 (2%) 2 (5%)
Heart (50) (50) (50) (50)
Cardiomyopathy 8 (16%) 6 (12%) 6 (12%) 6 (12%)
Mineralization 3 (6%) 3 (6%) 3 (6%)
Atrium, Thrombosis 1 (2%) 4 (8%) 3 (6%) 5 (10%)
Endocardium, Hyperplasia 1 (2%)
Myocardium, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hemorrhage 1 (2%)
Vacuolization Cytoplasmic 14 (28%) 8 (16%) 6 (12%) 3 (6%)
Adrenal Medulla (48) (50) (50) (49)
Hyperplasia 21 (44%) 19 (38%) 24 (48%) 27 (55%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 1 (2%) 2 (4%)
Parathyroid Gland (46) (48) (49) (46)
Hyperplasia 7 (15%) 5 (10%) 10 (20%) 11 (24%)
Pituitary Gland (49) (49) (48) (50)
Cyst 5 (10%) 6 (12%) 4 (8%) 8 (16%)
Hemorrhage 2 (4%) 3 (6%) 1 (2%) 1 (2%)
Craniopharyngeal Duct, Cyst 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 3 (6%) 3 (6%) 5 (10%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 5 (10%) 3 (6%) 3 (6%) 6 (12%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Hyperplasia, Tubular 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spermatocele 1 (2%)
Artery, Inflammation, Suppurative 1 (2%)
Penis (1) (1)
Inflammation, Suppurative 1 (100%)
Preputial Gland (49) (50) (50) (50)
Cyst 2 (4%) 1 (2%) 1 (2%)
Hyperplasia 2 (4%) 1 (2%) 3 (6%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 3 (6%) 1 (2%) 9 (18%) 6 (12%)
Prostate (50) (50) (50) (50)
Inflammation, Suppurative 6 (12%) 5 (10%) 5 (10%) 3 (6%)
Epithelium, Hyperplasia 2 (4%) 1 (2%) 5 (10%)
Seminal Vesicle (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Congestion 1 (2%)
Cyst 1 (2%)
Inflammation, Suppurative 2 (4%)
Testes (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Artery, Inflammation 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Germinal Epithelium, Atrophy 11 (22%) 7 (14%) 5 (10%) 7 (14%)
Interstitial Cell, Hyperplasia 3 (6%) 2 (4%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%) 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (16) (19) (18) (16)
Iliac, Inflammation, Suppurative 1 (6%)
Iliac, Pigmentation 1 (6%)
Lumbar, Pigmentation 1 (6%)
Pancreatic, Hyperplasia, Histiocytic 1 (5%)
Renal, Ectasia 1 (6%) 3 (16%) 3 (19%)
Renal, Fibrosis 1 (5%)
Renal, Hemorrhage 1 (6%) 2 (11%)
Renal, Hyperplasia, Histiocytic 1 (5%) 1 (6%)
Renal, Pigmentation 1 (6%)
Renal, Deep Cervical, Angiectasis 1 (6%)
Lymph Node, Bronchial (45) (45) (44) (43)
Fibrosis 3 (7%)
Hemorrhage 1 (2%) 1 (2%)
Lymph Node, Mandibular (46) (50) (49) (48)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (50) (49) (49)
Hemorrhage 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Lymph Node, Mediastinal (48) (50) (46) (49)
Angiectasis 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 3 (7%) 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 3 (6%) 2 (4%)
Fibrosis 14 (28%) 13 (26%) 16 (32%) 17 (34%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Necrosis 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Thymus (50) (49) (48) (50)
Hemorrhage 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 5 (10%) 3 (6%) 3 (6%)
Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Hyperkeratosis 5 (10%)
Hyperplasia 3 (6%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Inflammation, Suppurative 5 (10%) 1 (2%) 2 (4%) 1 (2%)
Necrosis 1 (2%)
Ulcer 4 (8%) 1 (2%) 4 (8%) 2 (4%)
Epidermis, Cyst 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Prepuce, Ulcer 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%) 1 (2%)
Subcutaneous Tissue, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Degeneration 1 (2%)
Fibrosis 5 (10%) 1 (2%)
Fracture 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperostosis 1 (2%)
Femur, Hyperplasia 1 (2%)
Turbinate, Maxilla, Fracture 1 (2%)
Turbinate, Maxilla, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Demyelination 1 (2%)
Developmental Malformation 1 (2%)
Gliosis 1 (2%)
Hemorrhage 8 (16%) 5 (10%) 7 (14%) 11 (22%)
Hydrocephalus 1 (2%) 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Meninges, Hyperplasia 1 (2%)
Ventricle, Hydrocephalus 7 (14%) 7 (14%) 9 (18%) 4 (8%)
Spinal Cord (1) (1) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (50) (49)
Foreign Body 3 (6%) 5 (10%) 3 (6%) 8 (16%)
Inflammation, Suppurative 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Epithelium, Hyperplasia 1 (2%) 2 (4%) 1 (2%) 4 (8%)
Epithelium, Metaplasia, Squamous 2 (4%) 3 (6%) 5 (10%)
Glands, Inflammation, Suppurative 3 (6%) 1 (2%) 3 (6%) 2 (4%)
Respiratory Epithelium, Epiglottis,
Hyperplasia 1 (2%)
Lung (50) (50) (50) (50)
Hemorrhage 16 (32%) 12 (24%) 17 (34%) 18 (36%)
Alveolar Epithelium, Fibrosis 1 (2%) 2 (4%) 1 (2%) 4 (8%)
Alveolar Epithelium, Hyperplasia 3 (6%) 4 (8%) 4 (8%) 6 (12%)
Alveolar Epithelium, Infiltration Cellular,
Histiocyte 7 (14%) 7 (14%) 8 (16%) 10 (20%)
Alveolar Epithelium, Inflammation,
Suppurative 1 (2%)
Alveolar Epithelium, Mineralization 3 (6%)
Artery, Infiltration Cellular, Histiocyte 1 (2%)
Artery, Mineralization 2 (4%) 1 (2%) 3 (6%)
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Metaplasia, Squamous 1 (2%)
Mediastinum, Fibrosis 1 (2%)
Nose (50) (49) (49) (50)
Foreign Body 6 (12%) 3 (6%) 5 (10%) 6 (12%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 8 (16%) 2 (4%) 8 (16%) 6 (12%)
Glands, Dilatation, Focal 1 (2%)
Goblet Cell, Respiratory Epithelium,
Hypertrophy 3 (6%) 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%)
Respiratory Epithelium, Hyperplasia 3 (6%) 1 (2%) 3 (6%) 3 (6%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) 2 (4%)
Pleura (2) (1) (2)
Inflammation, Chronic 1 (50%) 1 (100%)
Trachea (50) (49) (50) (49)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:30:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2)
Cataract 1 (33%)
Anterior Chamber, Inflammation, Suppurative 1 (50%)
Cornea, Inflammation, Chronic 1 (33%)
Cornea, Mineralization 2 (67%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 3 (6%) 3 (6%) 2 (4%) 5 (10%)
Fibrosis 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Nephropathy, Chronic 48 (96%) 50 (100%) 50 (100%) 50 (100%)
Thrombosis 1 (2%) 1 (2%) 3 (6%)
Cortex, Necrosis 1 (2%) 3 (6%)
Pelvis, Dilatation 2 (4%) 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 16 (32%) 13 (26%) 16 (32%) 18 (36%)
Pelvis, Transitional Epithelium,
Inflammation, Suppurative 1 (2%) 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Hyperplasia 7 (14%) 5 (10%) 6 (12%) 7 (14%)
Renal Tubule, Inflammation, Suppurative 1 (2%)
Renal Tubule, Mineralization 8 (16%) 7 (14%) 2 (4%) 5 (10%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%)
Urinary Bladder (50) (50) (49) (50)
Hemorrhage 2 (4%) 1 (2%) 2 (4%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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