TDMS Study 05181-03 Pathology Tables
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0109-99-9
Lock Date: 03/24/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 18 22 19 19
Natural Death 7 3 5 5
Survivors
Terminal Sacrifice 25 25 26 26
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (49) (49) (46)
Polyp Adenomatous 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Intestine Large, Rectum (48) (50) (50) (47)
Intestine Large, Cecum (47) (49) (46) (45)
Carcinoma 1 (2%)
Intestine Small, Duodenum (46) (49) (49) (47)
Intestine Small, Ileum (45) (49) (46) (45)
Liver (50) (49) (50) (50)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Mesentery (6) (9) (9) (3)
Osteosarcoma, Metastatic, Spleen 1 (11%)
Pancreas (48) (50) (50) (49)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (49) (49) (50) (49)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (49) (50) (49)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (50) (49) (50)
Pheochromocytoma Malignant 2 (4%) 1 (2%)
Pheochromocytoma Benign 1 (2%) 3 (6%) 3 (6%)
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NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (48) (50) (50) (49)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (49) (50) (50)
Pars Distalis, Adenoma 32 (65%) 38 (78%) 38 (76%) 34 (68%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Thyroid Gland (48) (50) (50) (49)
C-Cell, Adenoma 2 (4%) 3 (6%) 6 (12%) 4 (8%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 2 (4%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (48) (46) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Ovary (50) (50) (50) (50)
Granulosa-Theca Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Uterus (50) (50) (50) (50)
Leiomyoma 1 (2%)
Polyp Stromal 5 (10%) 8 (16%) 8 (16%) 6 (12%)
Sarcoma Stromal 1 (2%) 1 (2%) 1 (2%)
Vagina (1) (1)
Polyp 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (7) (7) (6) (5)
Lymph Node, Bronchial (46) (45) (41) (45)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node, Mandibular (45) (47) (48) (44)
Lymph Node, Mesenteric (48) (50) (50) (50)
Lymph Node, Mediastinal (48) (48) (48) (46)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Spleen (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Page 3
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (50) (50) (49) (48)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 5 (10%) 5 (10%) 5 (10%) 2 (4%)
Carcinoma, Multiple 1 (2%)
Fibroadenoma 14 (28%) 14 (28%) 23 (46%) 26 (52%)
Fibroadenoma, Multiple 9 (18%) 8 (16%) 6 (12%) 5 (10%)
Skin (50) (50) (50) (50)
Amelanotic Melanoma, Benign 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Pinna, Melanoma Benign 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Rib, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Lipoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (49) (50) (50) (49)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 17 (34%) 17 (34%) 18 (36%) 22 (44%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 47 49 48
Total Primary Neoplasms 103 108 122 119
Total Animals with Benign Neoplasms 42 45 48 43
Total Benign Neoplasms 71 79 92 82
Total Animals with Malignant Neoplasms 27 25 23 30
Total Malignant Neoplasms 32 29 30 37
Total Animals with Metastatic Neoplasms 1 1 3
Total Metastatic Neoplasm 2 3 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 31 39 40 34
Natural Death 6 4 5 10
Accidently Killed 1 1
Survivors
Terminal Sacrifice 12 6 5 6
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Intestine Large, Colon (49) (48) (48) (45)
Histiocytic Sarcoma 1 (2%)
Intestine Large, Cecum (49) (48) (48) (46)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Duodenum (49) (48) (49) (48)
Intestine Small, Jejunum (47) (46) (48) (44)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (47) (47) (47) (44)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 2 (4%)
Mesentery (15) (17) (18) (10)
Histiocytic Sarcoma 1 (7%)
Osteosarcoma, Metastatic, Bone 1 (6%)
Oral Mucosa (3) (1)
Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (49) (49) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Tongue (1) (2) (1)
Squamous Cell Papilloma 1 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (48) (50) (50) (49)
Pheochromocytoma Malignant 1 (2%) 3 (6%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 14 (29%) 4 (8%) 10 (20%) 11 (22%)
Pheochromocytoma Benign, Multiple 4 (8%) 7 (14%) 3 (6%) 3 (6%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 4 (8%) 2 (4%) 1 (2%) 2 (4%)
Carcinoma 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Pituitary Gland (49) (49) (48) (50)
Craniopharyngioma 1 (2%)
Pars Distalis, Adenoma 33 (67%) 34 (69%) 40 (83%) 27 (54%)
Pars Distalis, Adenoma, Multiple 2 (4%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Adenoma 4 (8%) 4 (8%) 4 (8%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Follicular Cell, Adenoma 2 (4%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (2) (1)
Histiocytic Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (49) (50) (50) (50)
Adenoma 2 (4%) 2 (4%) 2 (4%)
Carcinoma 3 (6%) 1 (2%) 4 (8%)
Prostate (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 12 (24%) 14 (28%) 16 (32%) 23 (46%)
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NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Interstitial Cell, Adenoma 11 (22%) 17 (34%) 15 (30%) 11 (22%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (16) (19) (18) (16)
Iliac, Histiocytic Sarcoma 1 (6%)
Renal, Histiocytic Sarcoma 1 (6%)
Lymph Node, Bronchial (45) (45) (44) (43)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Thymus 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Lymph Node, Mandibular (46) (50) (49) (48)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (50) (50) (49) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (48) (50) (46) (49)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Thymus 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Spleen (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymus (50) (49) (48) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymoma Benign 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Fibroadenoma 1 (2%) 3 (6%) 4 (8%)
Fibroadenoma, Multiple 1 (2%)
Skin (50) (50) (50) (50)
Fibroma, Multiple 1 (2%)
Keratoacanthoma 3 (6%) 3 (6%) 1 (2%) 2 (4%)
Keratoacanthoma, Multiple 1 (2%)
Schwannoma Malignant 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%) 1 (2%)
Pinna, Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 5 (10%) 3 (6%) 2 (4%)
Page 9
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Humerus, Osteosarcoma 1 (2%)
Rib, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Glioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Thymus 1 (2%)
Osteosarcoma, Metastatic, Bone 2 (4%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Pleura (2) (1) (2)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (2)
Carcinoma 1 (100%) 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 4 (8%) 2 (4%)
Renal Tubule, Adenoma, Multiple 1 (2%)
Renal Tubule, Carcinoma 2 (4%)
Urinary Bladder (50) (50) (49) (50)
Histiocytic Sarcoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%) 2 (4%)
Leukemia Mononuclear 30 (60%) 29 (58%) 27 (54%) 32 (64%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 2 (4%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05181-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:50:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 49 49 50
Total Primary Neoplasms 140 142 147 153
Total Animals with Benign Neoplasms 47 47 48 47
Total Benign Neoplasms 96 104 103 100
Total Animals with Malignant Neoplasms 37 33 32 42
Total Malignant Neoplasms 44 38 44 53
Total Animals with Metastatic Neoplasms 1 1 4 1
Total Metastatic Neoplasm 2 1 13 3
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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