TDMS Study 05181-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/20/96
EXPERIMENT: 05181 TEST: 03 TIME: 16:11:01
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. RENNE CAS: 0109-99-9
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/20/96
EXPERIMENT: 05181 TEST: 03 TIME: 16:11:01
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. RENNE CAS: 0109-99-9
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/20/96
EXPERIMENT: 05181 TEST: 03 TIME: 16:11:01
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. RENNE CAS: 0109-99-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TETRAHYDROFURAN
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Malignant
Clitoral/Preputial Gland Carcinoma or Adenoma
Kidney: Renal Tubule Carcinoma
Carcinoma or Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Testes Adenoma
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
All Organs Benign Tumors
====================================================================================================
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/48 (38%) 11/50 (22%) 13/50 (26%) 14/49 (29%) | 0/50 (0%) 1/50 (2%) 3/49 (6%) 3/50 (6%) |
|ADJUSTED (b) | 71.9% 60.9% 61.4% 70.0% | 0.0% 2.4% 9.6% 10.3% |
|TERMINAL (d) | 5/11 (45%) 1/6 (17%) 1/5 (20%) 2/6 (33%) | 0/25 (0%) 0/25 (0%) 2/26 (8%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 563 575 517 447 | --- 614 538 641 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.453 P=0.404N P=0.535 P=0.536 | P=0.111 P=0.505 P=0.135 P=0.122 |
|INCIDENTAL TUMOR | P=0.282N P=0.071N P=0.136N P=0.138N | P=0.178 P=0.419 P=0.076 P=0.157 |
|LOGISTIC REGRESSION | P=0.421N P=0.087N P=0.170N P=0.227N | P=0.109 P=0.495 P=0.113 P=0.120 |
|COCHRAN-ARMITAGE | P=0.442N | P=0.108 |
|FISHER EXACT | P=0.072N P=0.157N P=0.236N | P=0.500 P=0.117 P=0.121 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 1/50 (2%) 3/50 (6%) 1/49 (2%) | 2/50 (4%) 0/50 (0%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.3% 35.1% 12.5% | 5.7% 0.0% 0.0% 3.8% |
|TERMINAL (d) | 0/11 (0%) 0/6 (0%) 1/5 (20%) 0/6 (0%) | 0/25 (0%) 0/25 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- 660 590 727 | 642 --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429 P=0.462 P=0.047 * P=0.375 | P=0.661N P=0.240N P=0.251N P=0.520N |
|INCIDENTAL TUMOR | P=0.557 P=0.529 P=0.106 P=0.586 | P=0.620N P=0.265N P=0.200N P=0.484N |
|LOGISTIC REGRESSION | P=0.511 P=0.503 P=0.107 P=0.432 | P=0.646N P=0.236N P=0.239N P=0.498N |
|COCHRAN-ARMITAGE | P=0.514 | P=0.646N |
|FISHER EXACT | P=0.510 P=0.129 P=0.505 | P=0.247N P=0.253N P=0.500N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/48 (38%) 12/50 (24%) 16/50 (32%) 16/49 (33%) | 2/50 (4%) 1/50 (2%) 3/49 (6%) 4/50 (8%) |
|ADJUSTED (b) | 71.9% 63.1% 76.5% 74.7% | 5.7% 2.4% 9.6% 14.0% |
|TERMINAL (d) | 5/11 (45%) 1/6 (17%) 2/5 (40%) 2/6 (33%) | 0/25 (0%) 0/25 (0%) 2/26 (8%) 3/26 (12%) |
|FIRST INCIDENCE (DAYS) | 563 575 517 447 | 642 614 538 641 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.313 P=0.490N P=0.270 P=0.370 | P=0.164 P=0.497N P=0.510 P=0.327 |
|INCIDENTAL TUMOR | P=0.421N P=0.106N P=0.353N P=0.257N | P=0.247 P=0.578N P=0.462 P=0.393 |
|LOGISTIC REGRESSION | P=0.536 P=0.134N P=0.397N P=0.387N | P=0.167 P=0.501N P=0.489 P=0.337 |
|COCHRAN-ARMITAGE | P=0.513 | P=0.165 |
|FISHER EXACT | P=0.109N P=0.360N P=0.387N | P=0.500N P=0.490 P=0.339 |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 14.1% 0.0% | 4.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 1/25 (4%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 626 --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.717N (e) P=0.184 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|INCIDENTAL TUMOR | P=0.670N (e) P=0.304 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|LOGISTIC REGRESSION | P=0.696N (e) P=0.226 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|COCHRAN-ARMITAGE | P=0.695N | P=0.471N |
|FISHER EXACT | (e) P=0.247 (e) | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 2/50 (4%) 0/50 (0%) 2/50 (4%) | 1/48 (2%) 0/48 (0%) 0/46 (0%) 0/49 (0%) |
|ADJUSTED (b) | 11.0% 9.5% 0.0% 9.7% | 4.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/11 (9%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 1/24 (4%) 0/24 (0%) 0/26 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 406 439 --- 583 | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.578 P=0.632 P=0.323N P=0.636 | P=0.465N P=0.500N P=0.484N P=0.492N |
|INCIDENTAL TUMOR | P=0.628N P=0.674N P=0.367N P=0.693N | P=0.465N P=0.500N P=0.484N P=0.492N |
|LOGISTIC REGRESSION | P=0.607 P=0.670 P=0.250N P=0.696 | P=0.465N P=0.500N P=0.484N P=0.492N |
|COCHRAN-ARMITAGE | P=0.621 | P=0.468N |
|FISHER EXACT | P=0.684N P=0.242N P=0.684N | P=0.500N P=0.511N P=0.495N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 1/50 (2%) 0/50 (0%) 4/50 (8%) | 1/48 (2%) 1/48 (2%) 1/46 (2%) 3/49 (6%) |
|ADJUSTED (b) | 7.0% 2.1% 0.0% 30.3% | 4.2% 4.2% 3.8% 10.0% |
|TERMINAL (d) | 0/11 (0%) 0/6 (0%) 0/5 (0%) 1/6 (17%) | 1/24 (4%) 1/24 (4%) 1/26 (4%) 2/25 (8%) |
|FIRST INCIDENCE (DAYS) | 453 503 --- 607 | 733 (T) 733 (T) 733 (T) 498 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.184 P=0.306N P=0.113N P=0.427 | P=0.164 P=0.763 P=0.745N P=0.319 |
|INCIDENTAL TUMOR | P=0.227 P=0.195N P=0.132N P=0.549 | P=0.186 P=0.763 P=0.745N P=0.353 |
|LOGISTIC REGRESSION | P=0.195 P=0.398N P=0.148N P=0.503 | P=0.162 P=0.763 P=0.745N P=0.314 |
|COCHRAN-ARMITAGE | P=0.208 | P=0.164 |
|FISHER EXACT | P=0.301N P=0.117N P=0.511 | P=0.753N P=0.742 P=0.316 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 3/50 (6%) 0/50 (0%) 6/50 (12%) | 2/48 (4%) 1/48 (2%) 1/46 (2%) 3/49 (6%) |
|ADJUSTED (b) | 17.2% 11.4% 0.0% 37.1% | 8.3% 4.2% 3.8% 10.0% |
|TERMINAL (d) | 1/11 (9%) 0/6 (0%) 0/5 (0%) 1/6 (17%) | 2/24 (8%) 1/24 (4%) 1/26 (4%) 2/25 (8%) |
|FIRST INCIDENCE (DAYS) | 406 439 --- 583 | 733 (T) 733 (T) 733 (T) 498 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.217 P=0.405N P=0.046N* P=0.404 | P=0.294 P=0.500N P=0.472N P=0.517 |
|INCIDENTAL TUMOR | P=0.287 P=0.247N P=0.054N P=0.542 | P=0.318 P=0.500N P=0.472N P=0.552 |
|LOGISTIC REGRESSION | P=0.236 P=0.444N P=0.041N* P=0.502 | P=0.286 P=0.500N P=0.472N P=0.511 |
|COCHRAN-ARMITAGE | P=0.256 | P=0.292 |
|FISHER EXACT | P=0.346N P=0.027N* P=0.514 | P=0.500N P=0.516N P=0.510 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 1/50 (2%) 2/49 (4%) | 1/48 (2%) 1/50 (2%) 0/50 (0%) 1/49 (2%) |
|ADJUSTED (b) | 19.9% 5.9% 5.6% 22.2% | 2.5% 3.2% 0.0% 2.7% |
|TERMINAL (d) | 1/12 (8%) 0/6 (0%) 0/5 (0%) 1/6 (17%) | 0/25 (0%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 547 575 673 689 | 634 705 --- 634 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.451N P=0.450N P=0.331N P=0.516N | P=0.657 P=0.757 P=0.505N P=0.744 |
|INCIDENTAL TUMOR | P=0.377N P=0.326N P=0.165N P=0.355N | P=0.631N P=0.735 P=0.419N P=0.647N |
|LOGISTIC REGRESSION | P=0.386N P=0.335N P=0.185N P=0.365N | P=0.674 P=0.754N P=0.511N P=0.759 |
|COCHRAN-ARMITAGE | P=0.385N | P=0.678 |
|FISHER EXACT | P=0.339N P=0.181N P=0.349N | P=0.742N P=0.490N P=0.747N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 3/49 (6%) | 1/48 (2%) 1/50 (2%) 1/50 (2%) 1/49 (2%) |
|ADJUSTED (b) | 8.3% 19.0% 27.3% 14.1% | 4.0% 4.0% 3.8% 3.8% |
|TERMINAL (d) | 1/12 (8%) 1/6 (17%) 1/5 (20%) 0/6 (0%) | 1/25 (4%) 1/25 (4%) 1/26 (4%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 575 707 635 | 733 (T) 733 (T) 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.205 P=0.348 P=0.263 P=0.240 | P=0.657N P=0.763 P=0.754N P=0.754N |
|INCIDENTAL TUMOR | P=0.233 P=0.361 P=0.326 P=0.305 | P=0.657N P=0.763 P=0.754N P=0.754N |
|LOGISTIC REGRESSION | P=0.246 P=0.474 P=0.302 P=0.279 | P=0.657N P=0.763 P=0.754N P=0.754N |
|COCHRAN-ARMITAGE | P=0.259 | P=0.668N |
|FISHER EXACT | P=0.500 P=0.500 P=0.301 | P=0.742N P=0.742N P=0.747N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 4/50 (8%) 3/50 (6%) 5/49 (10%) | 2/48 (4%) 2/50 (4%) 1/50 (2%) 2/49 (4%) |
|ADJUSTED (b) | 27.2% 23.9% 31.3% 33.2% | 6.4% 7.1% 3.8% 6.4% |
|TERMINAL (d) | 2/12 (17%) 1/6 (17%) 1/5 (20%) 1/6 (17%) | 1/25 (4%) 1/25 (4%) 1/26 (4%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 547 575 673 635 | 634 705 733 (T) 634 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.394 P=0.591 P=0.638 P=0.437 | P=0.614 P=0.690 P=0.494N P=0.686 |
|INCIDENTAL TUMOR | P=0.477 P=0.573N P=0.445N P=0.618 | P=0.577N P=0.671 P=0.444N P=0.595N |
|LOGISTIC REGRESSION | P=0.484 P=0.505N P=0.420N P=0.593 | P=0.618 P=0.688N P=0.483N P=0.688N |
|COCHRAN-ARMITAGE | P=0.493 | P=0.621 |
|FISHER EXACT | P=0.500N P=0.357N P=0.617 | P=0.676N P=0.485N P=0.684N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 4/50 (8%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.3% 16.7% 18.8% 18.6% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/12 (8%) 1/6 (17%) 0/5 (0%) 0/6 (0%) | 0/25 (0%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) 631 668 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.195 P=0.602 P=0.120 P=0.213 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.281 P=0.602 P=0.184 P=0.356 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.213 P=0.602 P=0.159 P=0.262 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.224 | (e) |
|FISHER EXACT | P=0.753N P=0.181 P=0.309 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 24.2% | 4.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 1/6 (17%) | 1/25 (4%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 714 | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.026 * (e) (e) P=0.132 | P=0.465N P=0.500N P=0.492N P=0.492N |
|INCIDENTAL TUMOR | P=0.043 * (e) (e) P=0.204 | P=0.465N P=0.500N P=0.492N P=0.492N |
|LOGISTIC REGRESSION | P=0.031 * (e) (e) P=0.163 | P=0.465N P=0.500N P=0.492N P=0.492N |
|COCHRAN-ARMITAGE | P=0.042 * | P=0.471N |
|FISHER EXACT | (e) (e) P=0.247 | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 4/50 (8%) 5/50 (10%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.3% 16.7% 18.8% 38.3% | 4.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/12 (8%) 1/6 (17%) 0/5 (0%) 1/6 (17%) | 1/25 (4%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) 631 668 | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.031 * P=0.602 P=0.120 P=0.042 * | P=0.465N P=0.500N P=0.492N P=0.492N |
|INCIDENTAL TUMOR | P=0.060 P=0.602 P=0.184 P=0.107 | P=0.465N P=0.500N P=0.492N P=0.492N |
|LOGISTIC REGRESSION | P=0.037 * P=0.602 P=0.159 P=0.065 | P=0.465N P=0.500N P=0.492N P=0.492N |
|COCHRAN-ARMITAGE | P=0.044 * | P=0.471N |
|FISHER EXACT | P=0.753N P=0.181 P=0.102 | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 1/50 (2%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 15.2% 3.1% 0.0% | 4.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 1/25 (4%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- 540 621 --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.308N P=0.097 P=0.513 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|INCIDENTAL TUMOR | P=0.238N P=0.161 P=0.572 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|LOGISTIC REGRESSION | P=0.280N P=0.121 P=0.500 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|COCHRAN-ARMITAGE | P=0.281N | P=0.471N |
|FISHER EXACT | P=0.121 P=0.500 (e) | P=0.500N P=0.505N P=0.500N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 15.2% 6.3% 0.0% | 4.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 1/25 (4%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- 540 621 --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.314N P=0.097 P=0.258 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|INCIDENTAL TUMOR | P=0.255N P=0.161 P=0.320 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|LOGISTIC REGRESSION | P=0.289N P=0.121 P=0.237 (e) | P=0.465N P=0.500N P=0.492N P=0.492N |
|COCHRAN-ARMITAGE | P=0.291N | P=0.471N |
|FISHER EXACT | P=0.121 P=0.247 (e) | P=0.500N P=0.505N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 5/50 (10%) 5/50 (10%) 5/50 (10%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 15.7% 17.3% 14.9% 10.1% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 2/25 (8%) 3/25 (12%) 1/26 (4%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 642 651 547 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.293N P=0.615N P=0.623 P=0.375N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.290N P=0.617N P=0.546N P=0.332N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.272N P=0.623N P=0.616N P=0.354N |
|COCHRAN-ARMITAGE | (e) | P=0.274N |
|FISHER EXACT | (e) (e) (e) | P=0.630N P=0.630N P=0.357N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 5/50 (10%) 5/50 (10%) 5/50 (10%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 15.7% 17.3% 14.9% 10.1% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 2/25 (8%) 3/25 (12%) 1/26 (4%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 642 651 547 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.293N P=0.615N P=0.623 P=0.375N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.290N P=0.617N P=0.546N P=0.332N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.272N P=0.623N P=0.616N P=0.354N |
|COCHRAN-ARMITAGE | (e) | P=0.274N |
|FISHER EXACT | (e) (e) (e) | P=0.630N P=0.630N P=0.357N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 3/50 (6%) 4/50 (8%) | 23/50 (46%) 22/50 (44%) 29/50 (58%) 31/50 (62%) |
|ADJUSTED (b) | 0.0% 14.7% 12.3% 24.8% | 68.8% 61.3% 73.1% 79.3% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 15/25 (60%) 12/25 (48%) 16/26 (62%) 18/26 (69%) |
|FIRST INCIDENCE (DAYS) | --- 551 551 583 | 634 478 519 478 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.061 P=0.175 P=0.116 P=0.041 * | P=0.066 P=0.468N P=0.227 P=0.113 |
|INCIDENTAL TUMOR | P=0.088 P=0.275 P=0.182 P=0.087 | P=0.025 * P=0.419N P=0.235 P=0.037 * |
|LOGISTIC REGRESSION | P=0.076 P=0.238 P=0.120 P=0.062 | P=0.031 * P=0.478N P=0.211 P=0.056 |
|COCHRAN-ARMITAGE | P=0.075 | P=0.038 * |
|FISHER EXACT | P=0.247 P=0.121 P=0.059 | P=0.500N P=0.158 P=0.080 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 3/50 (6%) 4/50 (8%) | 24/50 (48%) 22/50 (44%) 29/50 (58%) 31/50 (62%) |
|ADJUSTED (b) | 0.0% 14.7% 12.3% 24.8% | 71.9% 61.3% 73.1% 79.3% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 16/25 (64%) 12/25 (48%) 16/26 (62%) 18/26 (69%) |
|FIRST INCIDENCE (DAYS) | --- 551 551 583 | 634 478 519 478 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.061 P=0.175 P=0.116 P=0.041 * | P=0.081 P=0.397N P=0.284 P=0.150 |
|INCIDENTAL TUMOR | P=0.088 P=0.275 P=0.182 P=0.087 | P=0.034 * P=0.338N P=0.303 P=0.058 |
|LOGISTIC REGRESSION | P=0.076 P=0.238 P=0.120 P=0.062 | P=0.042 * P=0.393N P=0.277 P=0.083 |
|COCHRAN-ARMITAGE | P=0.075 | P=0.050 |
|FISHER EXACT | P=0.247 P=0.121 P=0.059 | P=0.421N P=0.212 P=0.114 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 3/50 (6%) 4/50 (8%) | 27/50 (54%) 25/50 (50%) 33/50 (66%) 32/50 (64%) |
|ADJUSTED (b) | 0.0% 14.7% 12.3% 24.8% | 74.3% 70.2% 77.8% 79.9% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 16/25 (64%) 15/25 (60%) 17/26 (65%) 18/26 (69%) |
|FIRST INCIDENCE (DAYS) | --- 551 551 583 | 634 478 519 478 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.061 P=0.175 P=0.116 P=0.041 * | P=0.167 P=0.399N P=0.245 P=0.249 |
|INCIDENTAL TUMOR | P=0.088 P=0.275 P=0.182 P=0.087 | P=0.092 P=0.341N P=0.269 P=0.131 |
|LOGISTIC REGRESSION | P=0.076 P=0.238 P=0.120 P=0.062 | P=0.109 P=0.390N P=0.219 P=0.180 |
|COCHRAN-ARMITAGE | P=0.075 | P=0.119 |
|FISHER EXACT | P=0.247 P=0.121 P=0.059 | P=0.421N P=0.154 P=0.208 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.9% 0.0% 10.3% 7.4% | 0.0% 4.0% 0.0% 3.8% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 0/25 (0%) 1/25 (4%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 705 --- 639 505 | --- 733 (T) --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.272 P=0.553N P=0.423 P=0.460 | P=0.468 P=0.500 (e) P=0.508 |
|INCIDENTAL TUMOR | P=0.346 P=0.471N P=0.590 P=0.628 | P=0.468 P=0.500 (e) P=0.508 |
|LOGISTIC REGRESSION | P=0.271 P=0.536N P=0.481 P=0.502 | P=0.468 P=0.500 (e) P=0.508 |
|COCHRAN-ARMITAGE | P=0.269 | P=0.459 |
|FISHER EXACT | P=0.500N P=0.500 P=0.500 | P=0.500 (e) P=0.500 |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.9% 0.0% 10.3% 7.4% | 0.0% 4.0% 0.0% 3.8% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 0/25 (0%) 1/25 (4%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 705 --- 639 505 | --- 733 (T) --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.272 P=0.553N P=0.423 P=0.460 | P=0.468 P=0.500 (e) P=0.508 |
|INCIDENTAL TUMOR | P=0.346 P=0.471N P=0.590 P=0.628 | P=0.468 P=0.500 (e) P=0.508 |
|LOGISTIC REGRESSION | P=0.271 P=0.536N P=0.481 P=0.502 | P=0.468 P=0.500 (e) P=0.508 |
|COCHRAN-ARMITAGE | P=0.269 | P=0.459 |
|FISHER EXACT | P=0.500N P=0.500 P=0.500 | P=0.500 (e) P=0.500 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/49 (67%) 34/49 (69%) 40/48 (83%) 29/50 (58%) | 33/49 (67%) 38/49 (78%) 38/50 (76%) 34/50 (68%) |
|ADJUSTED (b) | 96.5% 90.5% 100.0% 86.5% | 79.7% 92.4% 85.8% 89.2% |
|TERMINAL (d) | 11/12 (92%) 3/6 (50%) 5/5 (100%) 3/6 (50%) | 17/25 (68%) 21/24 (88%) 20/26 (77%) 22/26 (85%) |
|FIRST INCIDENCE (DAYS) | 406 503 401 417 | 467 336 519 412 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.473N P=0.138 P=0.014 * P=0.402 | P=0.422N P=0.255 P=0.328 P=0.506 |
|INCIDENTAL TUMOR | P=0.066N P=0.555 P=0.031 * P=0.181N | P=0.387N P=0.164 P=0.337 P=0.549 |
|LOGISTIC REGRESSION | P=0.091N P=0.555 P=0.075 P=0.198N | P=0.349N P=0.156 P=0.270 P=0.545 |
|COCHRAN-ARMITAGE | P=0.107N | P=0.363N |
|FISHER EXACT | P=0.500 P=0.055 P=0.226N | P=0.183 P=0.232 P=0.558 |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 6/50 (12%) 1/50 (2%) 4/50 (8%) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 23.0% 28.0% 20.0% 27.9% | 8.0% 4.0% 3.8% 0.0% |
|TERMINAL (d) | 2/12 (17%) 0/6 (0%) 1/5 (20%) 1/6 (17%) | 2/25 (8%) 1/25 (4%) 1/26 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 575 607 733 (T) 594 | 733 (T) 733 (T) 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.562N P=0.248 P=0.348N P=0.498 | P=0.184N P=0.500N P=0.486N P=0.229N |
|INCIDENTAL TUMOR | P=0.534N P=0.365 P=0.303N P=0.549 | P=0.184N P=0.500N P=0.486N P=0.229N |
|LOGISTIC REGRESSION | P=0.480N P=0.351 P=0.210N P=0.635 | P=0.184N P=0.500N P=0.486N P=0.229N |
|COCHRAN-ARMITAGE | P=0.477N | P=0.193N |
|FISHER EXACT | P=0.370 P=0.181N P=0.643N | P=0.500N P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 4/50 (8%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 13.7% 40.2% 34.8% 23.1% | 0.0% 0.0% 7.7% 3.8% |
|TERMINAL (d) | 1/12 (8%) 2/6 (33%) 1/5 (20%) 1/6 (17%) | 0/25 (0%) 0/25 (0%) 2/26 (8%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 705 575 629 704 | --- --- 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.487N P=0.104 P=0.150 P=0.506 | P=0.364 (e) P=0.246 P=0.508 |
|INCIDENTAL TUMOR | P=0.422N P=0.141 P=0.281 P=0.657 | P=0.364 (e) P=0.246 P=0.508 |
|LOGISTIC REGRESSION | P=0.375N P=0.187 P=0.260 P=0.610 | P=0.364 (e) P=0.246 P=0.508 |
|COCHRAN-ARMITAGE | P=0.363N | P=0.354 |
|FISHER EXACT | P=0.218 P=0.339 P=0.691N | (e) P=0.247 P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 4/50 (8%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 13.7% 40.2% 34.8% 24.9% | 0.0% 4.0% 7.7% 7.7% |
|TERMINAL (d) | 1/12 (8%) 2/6 (33%) 1/5 (20%) 1/6 (17%) | 0/25 (0%) 1/25 (4%) 2/26 (8%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 705 575 629 516 | --- 733 (T) 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.520 P=0.104 P=0.150 P=0.326 | P=0.238 P=0.500 P=0.246 P=0.246 |
|INCIDENTAL TUMOR | P=0.588 P=0.141 P=0.281 P=0.478 | P=0.238 P=0.500 P=0.246 P=0.246 |
|LOGISTIC REGRESSION | P=0.553N P=0.187 P=0.260 P=0.485 | P=0.238 P=0.500 P=0.246 P=0.246 |
|COCHRAN-ARMITAGE | P=0.547N | P=0.228 |
|FISHER EXACT | P=0.218 P=0.339 P=0.500 | P=0.500 P=0.247 P=0.247 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 1/50 (2%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 15.3% 19.4% 20.0% 6.2% | 4.0% 0.0% 3.8% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/6 (0%) 1/5 (20%) 0/6 (0%) | 1/25 (4%) 0/25 (0%) 1/26 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 575 607 733 (T) 594 | 733 (T) --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.379N P=0.399 P=0.456N P=0.538N | P=0.451N P=0.500N P=0.754N P=0.492N |
|INCIDENTAL TUMOR | P=0.383N P=0.524 P=0.403N P=0.540N | P=0.451N P=0.500N P=0.754N P=0.492N |
|LOGISTIC REGRESSION | P=0.336N P=0.495 P=0.325N P=0.496N | P=0.451N P=0.500N P=0.754N P=0.492N |
|COCHRAN-ARMITAGE | P=0.338N | P=0.459N |
|FISHER EXACT | P=0.500 P=0.309N P=0.500N | P=0.500N P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 10.6% 0.0% 0.0% | 4.0% 4.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 1/25 (4%) 1/25 (4%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- 629 --- --- | 733 (T) 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.397N P=0.215 (e) (e) | P=0.298N P=0.763 P=0.492N P=0.492N |
|INCIDENTAL TUMOR | P=0.352N P=0.275 (e) (e) | P=0.298N P=0.763 P=0.492N P=0.492N |
|LOGISTIC REGRESSION | P=0.381N P=0.230 (e) (e) | P=0.298N P=0.763 P=0.492N P=0.492N |
|COCHRAN-ARMITAGE | P=0.380N | P=0.305N |
|FISHER EXACT | P=0.247 (e) (e) | P=0.753N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 6/50 (12%) 1/50 (2%) 3/50 (6%) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 15.3% 28.0% 20.0% 21.8% | 8.0% 4.0% 3.8% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/6 (0%) 1/5 (20%) 1/6 (17%) | 2/25 (8%) 1/25 (4%) 1/26 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 575 607 733 (T) 594 | 733 (T) 733 (T) 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.458N P=0.175 P=0.456N P=0.576 | P=0.184N P=0.500N P=0.486N P=0.229N |
|INCIDENTAL TUMOR | P=0.448N P=0.275 P=0.403N P=0.576 | P=0.184N P=0.500N P=0.486N P=0.229N |
|LOGISTIC REGRESSION | P=0.394N P=0.235 P=0.325N P=0.663N | P=0.184N P=0.500N P=0.486N P=0.229N |
|COCHRAN-ARMITAGE | P=0.395N | P=0.193N |
|FISHER EXACT | P=0.243 P=0.309N P=0.661N | P=0.500N P=0.500N P=0.247N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 6/50 (12%) 1/50 (2%) 2/50 (4%) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 15.3% 28.0% 20.0% 6.2% | 8.0% 4.0% 3.8% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/6 (0%) 1/5 (20%) 0/6 (0%) | 2/25 (8%) 1/25 (4%) 1/26 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 575 607 733 (T) 594 | 733 (T) 733 (T) 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.262N P=0.175 P=0.456N P=0.538N | P=0.184N P=0.500N P=0.486N P=0.229N |
|INCIDENTAL TUMOR | P=0.242N P=0.275 P=0.403N P=0.540N | P=0.184N P=0.500N P=0.486N P=0.229N |
|LOGISTIC REGRESSION | P=0.219N P=0.235 P=0.325N P=0.496N | P=0.184N P=0.500N P=0.486N P=0.229N |
|COCHRAN-ARMITAGE | P=0.221N | P=0.193N |
|FISHER EXACT | P=0.243 P=0.309N P=0.500N | P=0.500N P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/50 (46%) 31/50 (62%) 31/50 (62%) 34/50 (68%) | |
|ADJUSTED (b) | 78.9% 100.0% 100.0% 96.8% | |
|TERMINAL (d) | 7/12 (58%) 6/6 (100%) 5/5 (100%) 5/6 (83%) | |
|FIRST INCIDENCE (DAYS) | 546 439 561 505 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.040 * P=0.013 * P=0.009 ** P=0.009 ** | |
|INCIDENTAL TUMOR | P=0.054 P=0.047 * P=0.081 P=0.024 * | |
|LOGISTIC REGRESSION | P=0.036 * P=0.062 P=0.077 P=0.018 * | |
|COCHRAN-ARMITAGE | P=0.048 * | |
|FISHER EXACT | P=0.080 P=0.080 P=0.021 * | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 0/50 (0%) 4/50 (8%) | 2/48 (4%) 3/50 (6%) 6/50 (12%) 4/49 (8%) |
|ADJUSTED (b) | 16.1% 41.3% 0.0% 28.1% | 8.0% 10.4% 19.3% 14.3% |
|TERMINAL (d) | 1/12 (8%) 2/6 (33%) 0/5 (0%) 1/6 (17%) | 2/25 (8%) 2/25 (8%) 3/26 (12%) 3/26 (12%) |
|FIRST INCIDENCE (DAYS) | 453 607 --- 607 | 733 (T) 651 649 691 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.465 P=0.468 P=0.098N P=0.542 | P=0.340 P=0.505 P=0.144 P=0.352 |
|INCIDENTAL TUMOR | P=0.538 P=0.573 P=0.082N P=0.640N | P=0.269 P=0.514 P=0.152 P=0.320 |
|LOGISTIC REGRESSION | P=0.570 P=0.644 P=0.066N P=0.640N | P=0.326 P=0.509 P=0.143 P=0.321 |
|COCHRAN-ARMITAGE | P=0.568 | P=0.344 |
|FISHER EXACT | P=0.643N P=0.059N P=0.643N | P=0.520 P=0.148 P=0.349 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 3/50 (6%) 1/50 (2%) | 2/48 (4%) 1/50 (2%) 2/50 (4%) 2/49 (4%) |
|ADJUSTED (b) | 12.9% 23.1% 35.4% 4.5% | 8.0% 2.6% 6.4% 7.7% |
|TERMINAL (d) | 1/12 (8%) 1/6 (17%) 1/5 (20%) 0/6 (0%) | 2/25 (8%) 0/25 (0%) 1/26 (4%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 673 707 707 660 | 733 (T) 651 660 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.493N P=0.525 P=0.262 P=0.589N | P=0.530 P=0.494N P=0.681N P=0.683N |
|INCIDENTAL TUMOR | P=0.351N P=0.599 P=0.402 P=0.478N | P=0.493 P=0.482N P=0.676N P=0.683N |
|LOGISTIC REGRESSION | P=0.415N P=0.620 P=0.342 P=0.522N | P=0.524 P=0.493N P=0.688N P=0.683N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.534 |
|FISHER EXACT | P=0.691N P=0.500 P=0.500N | P=0.485N P=0.676N P=0.684N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 6/50 (12%) 3/50 (6%) 5/50 (10%) | 4/48 (8%) 3/50 (6%) 8/50 (16%) 6/49 (12%) |
|ADJUSTED (b) | 27.6% 59.4% 35.4% 31.4% | 16.0% 10.4% 24.9% 21.8% |
|TERMINAL (d) | 2/12 (17%) 3/6 (50%) 1/5 (20%) 1/6 (17%) | 4/25 (16%) 2/25 (8%) 4/26 (15%) 5/26 (19%) |
|FIRST INCIDENCE (DAYS) | 453 607 707 607 | 733 (T) 651 649 691 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.556 P=0.366 P=0.475N P=0.612 | P=0.260 P=0.496N P=0.193 P=0.389 |
|INCIDENTAL TUMOR | P=0.449N P=0.496 P=0.333N P=0.484N | P=0.194 P=0.488N P=0.202 P=0.363 |
|LOGISTIC REGRESSION | P=0.453N P=0.597 P=0.247N P=0.496N | P=0.237 P=0.489N P=0.189 P=0.349 |
|COCHRAN-ARMITAGE | P=0.446N | P=0.260 |
|FISHER EXACT | P=0.620N P=0.243N P=0.500N | P=0.477N P=0.199 P=0.383 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/48 (0%) 0/50 (0%) 1/50 (2%) 0/49 (0%) |
|ADJUSTED (b) | 5.3% 0.0% 2.7% 0.0% | 0.0% 0.0% 3.8% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 0/25 (0%) 0/25 (0%) 1/26 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 514 --- 591 --- | --- --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.256N P=0.233N P=0.450N P=0.232N | P=0.779N (e) P=0.508 (e) |
|INCIDENTAL TUMOR | P=0.273N P=0.184N P=0.455N P=0.219N | P=0.779N (e) P=0.508 (e) |
|LOGISTIC REGRESSION | P=0.287N P=0.266N P=0.537N P=0.263N | P=0.779N (e) P=0.508 (e) |
|COCHRAN-ARMITAGE | P=0.266N | P=0.786N |
|FISHER EXACT | P=0.247N P=0.500N P=0.247N | (e) P=0.510 (e) |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/48 (0%) 0/50 (0%) 1/50 (2%) 1/49 (2%) |
|ADJUSTED (b) | 9.4% 0.0% 5.7% 2.9% | 0.0% 0.0% 3.8% 3.8% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 0/25 (0%) 0/25 (0%) 1/26 (4%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 514 --- 591 594 | --- --- 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.414N P=0.131N P=0.472N P=0.296N | P=0.314 (e) P=0.508 P=0.508 |
|INCIDENTAL TUMOR | P=0.430N P=0.087N P=0.413N P=0.259N | P=0.314 (e) P=0.508 P=0.508 |
|LOGISTIC REGRESSION | P=0.443N P=0.127N P=0.518N P=0.320N | P=0.314 (e) P=0.508 P=0.508 |
|COCHRAN-ARMITAGE | P=0.429N | P=0.305 |
|FISHER EXACT | P=0.121N P=0.500N P=0.309N | (e) P=0.510 P=0.505 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.9% 0.0% 10.3% 5.3% | 0.0% 4.0% 0.0% 3.8% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 0/25 (0%) 1/25 (4%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 705 --- 639 677 | --- 733 (T) --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.555 P=0.553N P=0.423 P=0.722 | P=0.468 P=0.500 (e) P=0.508 |
|INCIDENTAL TUMOR | P=0.636 P=0.471N P=0.590 P=0.664N | P=0.468 P=0.500 (e) P=0.508 |
|LOGISTIC REGRESSION | P=0.554 P=0.536N P=0.481 P=0.749 | P=0.468 P=0.500 (e) P=0.508 |
|COCHRAN-ARMITAGE | P=0.558 | P=0.459 |
|FISHER EXACT | P=0.500N P=0.500 P=0.753N | P=0.500 (e) P=0.500 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 5/50 (10%) 8/50 (16%) 8/50 (16%) 6/50 (12%) |
|ADJUSTED (b) | | 18.1% 25.7% 26.5% 19.5% |
|TERMINAL (d) | | 4/25 (16%) 4/25 (16%) 5/26 (19%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | | 634 651 674 532 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.524N P=0.293 P=0.294 P=0.511 |
|INCIDENTAL TUMOR | | P=0.554N P=0.287 P=0.327 P=0.595 |
|LOGISTIC REGRESSION | | P=0.542N P=0.283 P=0.289 P=0.503 |
|COCHRAN-ARMITAGE | | P=0.530N |
|FISHER EXACT | | P=0.277 P=0.277 P=0.500 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 6/50 (12%) 9/50 (18%) 8/50 (16%) 7/50 (14%) |
|ADJUSTED (b) | | 20.7% 27.2% 26.5% 21.9% |
|TERMINAL (d) | | 4/25 (16%) 4/25 (16%) 5/26 (19%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | | 634 478 674 532 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.534N P=0.307 P=0.399 P=0.498 |
|INCIDENTAL TUMOR | | P=0.561 P=0.307 P=0.447 P=0.541 |
|LOGISTIC REGRESSION | | P=0.535N P=0.294 P=0.405 P=0.505 |
|COCHRAN-ARMITAGE | | P=0.534N |
|FISHER EXACT | | P=0.288 P=0.387 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.0% 0.0% 5.0% 5.0% | 0.0% 0.0% 0.0% 3.8% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 0/25 (0%) 0/25 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 673 --- 646 511 | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.252 P=0.545N P=0.724 P=0.508 | P=0.221 (e) (e) P=0.508 |
|INCIDENTAL TUMOR | P=0.290 P=0.471N P=0.717N P=0.571 | P=0.221 (e) (e) P=0.508 |
|LOGISTIC REGRESSION | P=0.229 P=0.510N P=0.761 P=0.483 | P=0.221 (e) (e) P=0.508 |
|COCHRAN-ARMITAGE | P=0.235 | P=0.215 |
|FISHER EXACT | P=0.500N P=0.753N P=0.500 | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 29/50 (58%) 27/50 (54%) 32/50 (64%) | 17/50 (34%) 17/50 (34%) 18/50 (36%) 22/50 (44%) |
|ADJUSTED (b) | 96.1% 90.7% 90.7% 84.6% | 41.5% 45.3% 51.5% 52.9% |
|TERMINAL (d) | 11/12 (92%) 4/6 (67%) 3/5 (60%) 3/6 (50%) | 4/25 (16%) 7/25 (28%) 10/26 (38%) 8/26 (31%) |
|FIRST INCIDENCE (DAYS) | 422 439 517 431 | 411 467 575 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.215 P=0.203 P=0.231 P=0.182 | P=0.174 P=0.559N P=0.528 P=0.243 |
|INCIDENTAL TUMOR | P=0.349 P=0.580N P=0.404N P=0.396 | P=0.223 P=0.563 P=0.556 P=0.348 |
|LOGISTIC REGRESSION | P=0.338 P=0.465N P=0.283N P=0.454 | P=0.199 P=0.581 P=0.507 P=0.294 |
|COCHRAN-ARMITAGE | P=0.318 | P=0.142 |
|FISHER EXACT | P=0.500N P=0.343N P=0.418 | P=0.583N P=0.500 P=0.206 |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 9.4% 6.2% 2.4% 3.7% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 0/25 (0%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 621 514 561 644 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.401N P=0.628 P=0.588N P=0.573N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.383N P=0.616N P=0.393N P=0.465N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.385N P=0.694N P=0.497N P=0.503N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.383N | (e) |
|FISHER EXACT | P=0.691N P=0.500N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 14.1% 0.0% | 4.0% 0.0% 2.7% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 1/25 (4%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 626 --- | 733 (T) --- 660 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.717N (e) P=0.184 (e) | P=0.466N P=0.500N P=0.753N P=0.492N |
|INCIDENTAL TUMOR | P=0.670N (e) P=0.304 (e) | P=0.503N P=0.500N P=0.747N P=0.492N |
|LOGISTIC REGRESSION | P=0.696N (e) P=0.226 (e) | P=0.460N P=0.500N P=0.755N P=0.492N |
|COCHRAN-ARMITAGE | P=0.695N | P=0.459N |
|FISHER EXACT | (e) P=0.247 (e) | P=0.500N P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 14.1% 0.0% | 4.0% 0.0% 2.7% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/6 (0%) 0/5 (0%) 0/6 (0%) | 1/25 (4%) 0/25 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 626 --- | 733 (T) --- 660 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.717N (e) P=0.184 (e) | P=0.466N P=0.500N P=0.753N P=0.492N |
|INCIDENTAL TUMOR | P=0.670N (e) P=0.304 (e) | P=0.503N P=0.500N P=0.747N P=0.492N |
|LOGISTIC REGRESSION | P=0.696N (e) P=0.226 (e) | P=0.460N P=0.500N P=0.755N P=0.492N |
|COCHRAN-ARMITAGE | P=0.695N | P=0.459N |
|FISHER EXACT | (e) P=0.247 (e) | P=0.500N P=0.753N P=0.500N |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 47/50 (94%) 47/50 (94%) 48/50 (96%) 47/50 (94%) | 42/50 (84%) 45/50 (90%) 48/50 (96%) 43/50 (86%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 97.6% 95.7% 100.0% 97.7% |
|TERMINAL (d) | 12/12 (100%) 6/6 (100%) 5/5 (100%) 6/6 (100%) | 24/25 (96%) 23/25 (92%) 26/26 (100%) 25/26 (96%) |
|FIRST INCIDENCE (DAYS) | 406 439 401 417 | 467 336 519 412 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306 P=0.136 P=0.094 P=0.183 | P=0.495N P=0.417 P=0.286 P=0.509 |
|INCIDENTAL TUMOR | P=0.332N P=0.403N P=0.692N P=0.337N | P=0.356N P=0.232 P=0.222 P=0.621N |
|LOGISTIC REGRESSION | P=0.438N P=0.290N P=0.639N P=0.386N | P=0.377N P=0.298 P=0.146 P=0.607 |
|COCHRAN-ARMITAGE | P=0.597N | P=0.513N |
|FISHER EXACT | P=0.661N P=0.500 P=0.661N | P=0.277 P=0.046 * P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 37/50 (74%) 34/50 (68%) 32/50 (64%) 42/50 (84%) | 27/50 (54%) 25/50 (50%) 23/50 (46%) 30/50 (60%) |
|ADJUSTED (b) | 97.0% 96.2% 95.9% 94.2% | 62.6% 64.1% 61.0% 70.2% |
|TERMINAL (d) | 11/12 (92%) 5/6 (83%) 4/5 (80%) 4/6 (67%) | 10/25 (40%) 12/25 (48%) 12/26 (46%) 14/26 (54%) |
|FIRST INCIDENCE (DAYS) | 422 439 517 431 | 411 467 547 498 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.084 P=0.265 P=0.306 P=0.089 | P=0.258 P=0.422N P=0.288N P=0.375 |
|INCIDENTAL TUMOR | P=0.091 P=0.325N P=0.220N P=0.275 | P=0.310 P=0.432N P=0.211N P=0.531 |
|LOGISTIC REGRESSION | P=0.070 P=0.259N P=0.121N P=0.204 | P=0.220 P=0.413N P=0.249N P=0.462 |
|COCHRAN-ARMITAGE | P=0.063 | P=0.212 |
|FISHER EXACT | P=0.330N P=0.194N P=0.163 | P=0.421N P=0.274N P=0.343 |
|=================================================================================================================================|
DATE: 02/21/96 EXPERIMENT: 05181 TEST: 03 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 200 PPM 600 PPM 1800 PPM | CONTROL 200 PPM 600 PPM 1800 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 49/50 (98%) 49/50 (98%) 50/50 (100%)| 46/50 (92%) 47/50 (94%) 49/50 (98%) 48/50 (96%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 97.8% 97.9% 100.0% 98.0% |
|TERMINAL (d) | 12/12 (100%) 6/6 (100%) 5/5 (100%) 6/6 (100%) | 24/25 (96%) 24/25 (96%) 26/26 (100%) 25/26 (96%) |
|FIRST INCIDENCE (DAYS) | 406 439 401 417 | 411 336 519 412 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.243 P=0.118 P=0.099 P=0.137 | P=0.445 P=0.538 P=0.468 P=0.455 |
|INCIDENTAL TUMOR | P=0.563 P=0.571N (e) (e) | P=0.627N P=0.486 P=0.477 P=0.681N |
|LOGISTIC REGRESSION | P=0.493 P=0.435N (e) (e) | P=0.511 P=0.588 P=0.436 P=0.547 |
|COCHRAN-ARMITAGE | P=0.193 | P=0.305 |
|FISHER EXACT | P=0.500 P=0.500 P=0.247 | P=0.500 P=0.181 P=0.339 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).