TDMS Study 05181-03 Pathology Tables
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0109-99-9
Lock Date: 03/24/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 4| 5| 6| 5| 7| 6| 7| 1| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 0| 0| 3| 4| 7| 6| 6| 4| 2| 3| 6| 3| 4| 2| 3| 3|
| 5| 5| 4| 5| 3| 3| 4| 4| 4| 5| 1| 3| 7| 2| 7| 3| 2| 3| 3| 7| 3| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + A + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + A + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + A + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X |
Clear Cell Focus | X X X |
Degeneration, Cystic | 4 4 |
Hepatodiaphragmatic Nodule | X X X X|
Hyperplasia, Reticulum Cell | 4 |
Vacuolization Cytoplasmic | 4 4 4 3 |
Hepatocyte, Necrosis | 2 |
Serosa, Fibrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Granulomatous | 2 |
Fat, Necrosis | 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + A + + +|
Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperkeratosis | |
Hyperplasia | 2 4 2 |
Inflammation, Suppurative | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Mineralization | |
Necrosis | 4 |
Ulcer | 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Thrombosis | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 4| 5| 6| 5| 7| 6| 7| 1| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 0| 0| 3| 4| 7| 6| 6| 4| 2| 3| 6| 3| 4| 2| 3| 3|
| 5| 5| 4| 5| 3| 3| 4| 4| 4| 5| 1| 3| 7| 2| 7| 3| 2| 3| 3| 7| 3| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemorrhage | 3 |
Vacuolization Cytoplasmic | 2 3 2 3 |
Zona Reticularis, Pigmentation | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + A + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + M + + + + + + + M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Cyst | 2 4 4 3 2 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 3 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + A + + +|
C-Cell, Hyperplasia | 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 4 2 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Reticulum Cell | 3 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia, Histiocytic | 2 |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Pigmentation | 1 |
Lumbar, Pigmentation | 1 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + M + + + M M + + + +|
Infiltration Cellular, Histiocyte | 4 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 4| 5| 6| 5| 7| 6| 7| 1| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 0| 0| 3| 4| 7| 6| 6| 4| 2| 3| 6| 3| 4| 2| 3| 3|
| 5| 5| 4| 5| 3| 3| 4| 4| 4| 5| 1| 3| 7| 2| 7| 3| 2| 3| 3| 7| 3| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + A + + +|
Hemorrhage | 3 |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 |
Hemorrhage | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 |
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 3 |
Hyperplasia | |
Inflammation, Suppurative | |
Epidermis, Cyst | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cartilage, Sternum, Degeneration, | |
Mucoid | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Hemorrhage | 3 2 2 3 |
Ventricle, Hydrocephalus | 3 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X|
Inflammation, Suppurative | 4 3|
Epiglottis, Metaplasia, Squamous | |
Epithelium, Hyperplasia | 2 2|
Epithelium, Metaplasia, Squamous | 2|
Glands, Inflammation, Suppurative | 4 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 4| 5| 6| 5| 7| 6| 7| 1| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 0| 0| 3| 4| 7| 6| 6| 4| 2| 3| 6| 3| 4| 2| 3| 3|
| 5| 5| 4| 5| 3| 3| 4| 4| 4| 5| 1| 3| 7| 2| 7| 3| 2| 3| 3| 7| 3| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Fibrosis | 1 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 4 2 |
Alveolar Epithelium, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
Foreign Body | |
Inflammation, Suppurative | |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 3 |
Cataract | |
Cornea, Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 1 1 2 3 2 2 2 1 2 3 2 2 1 1 3 2 1 1 2 2 2|
Papilla, Necrosis | |
Pelvis, Dilatation | |
Renal Tubule, Mineralization | 2 1 2 2 2 2 2 2 3 2 2 2 2 2 2 3 2 1 2 2 3 2 1 2|
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hemorrhage | |
Inflammation, Suppurative | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 1| 0| 0| 9| 3| 3| 3| 1| 7| 3| 1| 1| 6| 5| |
| 5| 3| 3| 3| 7| 3| 4| 4| 5| 4| 4| 0| 4| 5| 7| 3| 3| 3| 5| 8| 4| 1| 8| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 | 3 3.0|
Basophilic Focus | X X X X | 6 |
Clear Cell Focus | X X X | 6 |
Degeneration, Cystic | | 2 4.0|
Hepatodiaphragmatic Nodule | X X | 6 |
Hyperplasia, Reticulum Cell | 3 | 2 3.5|
Vacuolization Cytoplasmic | 4 3 3 | 7 3.6|
Hepatocyte, Necrosis | 2 | 2 2.0|
Serosa, Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Inflammation, Granulomatous | 3 | 2 2.5|
Fat, Necrosis | | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 1 3| 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia | 3 2 3| 6 2.7|
Inflammation, Suppurative | | 1 4.0|
Ulcer | 4| 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 2 | 1 2.0|
Necrosis | | 1 4.0|
Ulcer | | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Thrombosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 1| 0| 0| 9| 3| 3| 3| 1| 7| 3| 1| 1| 6| 5| |
| 5| 3| 3| 3| 7| 3| 4| 4| 5| 4| 4| 0| 4| 5| 7| 3| 3| 3| 5| 8| 4| 1| 8| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Vacuolization Cytoplasmic | 1 2 | 6 2.2|
Zona Reticularis, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 4 2 4 | 9 3.1|
Hemorrhage | 3| 2 3.5|
Pars Distalis, Hyperplasia | 3 3 2 | 5 2.8|
Pars Nervosa, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 2 3 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 3 | 2 3.0|
Inflammation, Granulomatous | 4 | 1 4.0|
Inflammation, Suppurative | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2 4 3 | 9 2.7|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Reticulum Cell | 3 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 1| 0| 0| 9| 3| 3| 3| 1| 7| 3| 1| 1| 6| 5| |
| 5| 3| 3| 3| 7| 3| 4| 4| 5| 4| 4| 0| 4| 5| 7| 3| 3| 3| 5| 8| 4| 1| 8| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 7 |
Iliac, Hyperplasia, Histiocytic | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | 4 4 | 2 4.0|
Iliac, Pigmentation | | 1 1.0|
Lumbar, Pigmentation | | 1 1.0|
Renal, Hyperplasia, Lymphoid | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + M + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Infiltration Cellular, Histiocyte | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 3 3.3|
Hemorrhage | 3 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 3 3.0|
Duct, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 3 3.3|
Hyperplasia | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
Epidermis, Cyst | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cartilage, Sternum, Degeneration, | | |
Mucoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 1| 0| 0| 9| 3| 3| 3| 1| 7| 3| 1| 1| 6| 5| |
| 5| 3| 3| 3| 7| 3| 4| 4| 5| 4| 4| 0| 4| 5| 7| 3| 3| 3| 5| 8| 4| 1| 8| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | 1 | 1 1.0|
Hemorrhage | 4 4 | 6 3.0|
Ventricle, Hydrocephalus | 3 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 6 |
Inflammation, Suppurative | 2 | 3 3.0|
Epiglottis, Metaplasia, Squamous | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 3 2.0|
Epithelium, Metaplasia, Squamous | 2 | 2 2.0|
Glands, Inflammation, Suppurative | 1 | 3 2.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 8 1.3|
Alveolar Epithelium, Fibrosis | | 1 1.0|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 2 2 2 | 5 2.4|
Alveolar Epithelium, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X | 1 |
Inflammation, Suppurative | 3 1 | 2 2.0|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Atrophy | | 1 3.0|
Cataract | 2 | 1 2.0|
Cornea, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 3 2 1 1 2 2 2 2 2 2 2 2 3 3 1 2 3 3 1 1 1 2 2| 48 1.9|
Papilla, Necrosis | 4 | 1 4.0|
Pelvis, Dilatation | 4 | 1 4.0|
Renal Tubule, Mineralization | 1 3 2 2 2 1 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2| 47 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 1| 0| 0| 9| 3| 3| 3| 1| 7| 3| 1| 1| 6| 5| |
| 5| 3| 3| 3| 7| 3| 4| 4| 5| 4| 4| 0| 4| 5| 7| 3| 3| 3| 5| 8| 4| 1| 8| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 9| 3| 7| 1| 8| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 5| 0| 3| 3| 6|
| 3| 1| 5| 0| 9| 1| 3| 5| 4| 6| 3| 4| 4| 5| 5| 5| 3| 4| 1| 3| 8| 0| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 2 |
Basophilic Focus | X X |
Clear Cell Focus | X X X |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 1 2|
Vacuolization Cytoplasmic | 4 3 3 4 4|
Hepatocyte, Necrosis | |
Hepatocyte, Regeneration | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Mineralization | |
Fat, Necrosis | 3 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3|
Hyperplasia | 1 3|
Inflammation, Suppurative | 1 3|
Necrosis | 4 |
Ulcer | 3 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 9| 3| 7| 1| 8| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 5| 0| 3| 3| 6|
| 3| 1| 5| 0| 9| 1| 3| 5| 4| 6| 3| 4| 4| 5| 5| 5| 3| 4| 1| 3| 8| 0| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
Vacuolization Cytoplasmic | 2 1 1 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + M + + + + + + + + + + + + + + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | 4 |
Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 4 |
C-Cell, Hyperplasia | 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 3 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Bilateral, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + +|
Pancreatic, Pigmentation | 4|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 9| 3| 7| 1| 8| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 5| 0| 3| 3| 6|
| 3| 1| 5| 0| 9| 1| 3| 5| 4| 6| 3| 4| 4| 5| 5| 5| 3| 4| 1| 3| 8| 0| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Necrosis | 4 |
Pigmentation | 4|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 |
Ventricle, Hydrocephalus | 3 4 3 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 2 |
Epiglottis, Metaplasia, Squamous | 1 |
Epithelium, Hyperplasia | |
Epithelium, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 2 1 2 1 1 1 1|
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 3 3|
Nasopharyngeal Duct, Hyperplasia | 4 |
Olfactory Epithelium, Metaplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 9| 3| 7| 1| 8| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 5| 0| 3| 3| 6|
| 3| 1| 5| 0| 9| 1| 3| 5| 4| 6| 3| 4| 4| 5| 5| 5| 3| 4| 1| 3| 8| 0| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Nephropathy, Chronic | 1 2 2 2 2 2 3 3 2 3 2 3 2 2 2 3 1 2 2 2 2 3|
Cortex, Necrosis | 3 |
Renal Tubule, Mineralization | 2 1 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 0| 6| 7| 6| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6| 4| 5| 7| |
DAY ON TEST | 8| 3| 3| 5| 1| 3| 5| 2| 0| 8| 3| 0| 3| 0| 3| 3| 7| 3| 1| 3| 3| 9| 6| 9| 3| |
| 7| 3| 4| 1| 9| 3| 8| 4| 5| 1| 3| 5| 5| 5| 4| 3| 8| 4| 9| 4| 3| 5| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 3 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 4 3.0|
Basophilic Focus | | 2 |
Clear Cell Focus | X X X X | 7 |
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Granulomatous | | 2 1.5|
Vacuolization Cytoplasmic | 4 2 4 3 4 3 3 3 4 2 3 | 16 3.3|
Hepatocyte, Necrosis | 3 | 1 3.0|
Hepatocyte, Regeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Mineralization | 4 | 1 4.0|
Fat, Necrosis | 4 3 3 4 | 8 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 2 2 3| 6 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Hyperkeratosis | | 1 3.0|
Hyperplasia | 2 3 1 2 2 | 7 2.0|
Inflammation, Suppurative | 2 | 3 2.0|
Necrosis | | 1 4.0|
Ulcer | 4 4 4 | 5 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 0| 6| 7| 6| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6| 4| 5| 7| |
DAY ON TEST | 8| 3| 3| 5| 1| 3| 5| 2| 0| 8| 3| 0| 3| 0| 3| 3| 7| 3| 1| 3| 3| 9| 6| 9| 3| |
| 7| 3| 4| 1| 9| 3| 8| 4| 5| 1| 3| 5| 5| 5| 4| 3| 8| 4| 9| 4| 3| 5| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 4 2 2 3 4 3| 10 2.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M + + + + M + + + + + + + + + +| 43 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 2 1 3 | 6 2.3|
Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 4.0|
C-Cell, Hyperplasia | 3 3 2 1 | 6 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 4 3 | 4 3.3|
Inflammation, Suppurative | 4 3 | 3 3.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 1 | 3 3.0|
Bilateral, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 0| 6| 7| 6| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6| 4| 5| 7| |
DAY ON TEST | 8| 3| 3| 5| 1| 3| 5| 2| 0| 8| 3| 0| 3| 0| 3| 3| 7| 3| 1| 3| 3| 9| 6| 9| 3| |
| 7| 3| 4| 1| 9| 3| 8| 4| 5| 1| 3| 5| 5| 5| 4| 3| 8| 4| 9| 4| 3| 5| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 7 |
Pancreatic, Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + M + + + + + + + + + + + + + + +| 45 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | 3 3 | 3 3.0|
Necrosis | 3 | 2 3.5|
Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 3 2.0|
Ventricle, Hydrocephalus | 3 3 2 2| 8 2.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X| 2 |
Inflammation, Suppurative | | 1 2.0|
Epiglottis, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 0| 6| 7| 6| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6| 4| 5| 7| |
DAY ON TEST | 8| 3| 3| 5| 1| 3| 5| 2| 0| 8| 3| 0| 3| 0| 3| 3| 7| 3| 1| 3| 3| 9| 6| 9| 3| |
| 7| 3| 4| 1| 9| 3| 8| 4| 5| 1| 3| 5| 5| 5| 4| 3| 8| 4| 9| 4| 3| 5| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 2 2 3| 3 2.3|
Epithelium, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 1 1 3 1 | 15 1.5|
Alveolar Epithelium, Hyperplasia | 2 3 | 2 2.5|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 2 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Foreign Body | X | 3 |
Inflammation, Suppurative | 2 | 4 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 4 3.0|
Nasopharyngeal Duct, Hyperplasia | | 1 4.0|
Olfactory Epithelium, Metaplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.0|
Nephropathy, Chronic | 3 2 3 2 2 1 1 2 1 3 3 2 3 3 1 3 2 2 2 2 2 2| 44 2.2|
Cortex, Necrosis | | 1 3.0|
Renal Tubule, Mineralization | 1 2 2 2 1 1 2 2 2 3 2 2 2 1 1 2 3 2 2 1 2 2 2 2 2| 46 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 4 1 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 6| 6| 5| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 4| 3| 3| 3| 3| 2| 6| 3| 7| 3|
| 9| 5| 3| 3| 7| 4| 4| 5| 3| 3| 4| 3| 4| 9| 3| 9| 3| 3| 5| 5| 6| 3| 8| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + A + + + + + A + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hepatodiaphragmatic Nodule | X X |
Vacuolization Cytoplasmic | 2 3 3 2 3 4 |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Oral Mucosa | |
Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Atrium, Thrombosis | |
Endocardium, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 3 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3|
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 6| 6| 5| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 4| 3| 3| 3| 3| 2| 6| 3| 7| 3|
| 9| 5| 3| 3| 7| 4| 4| 5| 3| 3| 4| 3| 4| 9| 3| 9| 3| 3| 5| 5| 6| 3| 8| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 4 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 4 |
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + M + + M + + + + + + + + + M + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3|
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 6| 6| 5| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 4| 3| 3| 3| 3| 2| 6| 3| 7| 3|
| 9| 5| 3| 3| 7| 4| 4| 5| 3| 3| 4| 3| 4| 9| 3| 9| 3| 3| 5| 5| 6| 3| 8| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
Necrosis | |
Ventricle, Hydrocephalus | 2 3 2 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + I + + + + + + + + + + + + I + + + + +|
Foreign Body | X X |
Epithelium, Hyperplasia | |
Epithelium, Metaplasia, Squamous | 2 |
Glands, Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 2 1 2 1 1 |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 2 3 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Respiratory Epithelium, Hyperplasia | 4 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 1 2 1 2 2 1 3 3 2 2 2 1 1 3 3 2 3 2 1 3 2|
Renal Tubule, Degeneration | |
Renal Tubule, Mineralization | 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 1 2 2 2 2 2|
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 5| 4| 7| 4| 3| 3| 3| 3| 6| 8| 9| 3| 3| 7| 9| 9| 2| 6| 9| 3| 0| 3| 9| 3| 3| |
| 9| 7| 5| 9| 5| 5| 4| 4| 0| 7| 7| 4| 4| 7| 7| 7| 7| 7| 9| 3| 5| 5| 9| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + A + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
Vacuolization Cytoplasmic | 3 4 4 4 3 3 | 12 3.2|
Hepatocyte, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Fat, Necrosis | 3 3 3 1 | 7 2.7|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 | 1 3.0|
Hyperplasia | 2 2 | 3 2.3|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 2.0|
Atrium, Thrombosis | 4 | 1 4.0|
Endocardium, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 2 2 2 | 7 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 5| 4| 7| 4| 3| 3| 3| 3| 6| 8| 9| 3| 3| 7| 9| 9| 2| 6| 9| 3| 0| 3| 9| 3| 3| |
| 9| 7| 5| 9| 5| 5| 4| 4| 0| 7| 7| 4| 4| 7| 7| 7| 7| 7| 9| 3| 5| 5| 9| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + I + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 3 3 2 3 | 9 2.9|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + + + + M + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 | 4 2.5|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 | 6 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 2 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + M + + + M + + + + + M + + + +| 46 |
Cyst | 4| 1 4.0|
Hyperplasia | 4 4 | 3 4.0|
Inflammation, Suppurative | 3| 3 3.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 4 | 5 3.2|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + + M + + + + + M + + + + + M + + +| 41 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + M| 48 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + M M + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 5| 4| 7| 4| 3| 3| 3| 3| 6| 8| 9| 3| 3| 7| 9| 9| 2| 6| 9| 3| 0| 3| 9| 3| 3| |
| 9| 7| 5| 9| 5| 5| 4| 4| 0| 7| 7| 4| 4| 7| 7| 7| 7| 7| 9| 3| 5| 5| 9| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 4 2| 5 2.4|
Necrosis | 4 | 1 4.0|
Ventricle, Hydrocephalus | 2 3 3 | 8 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | X X X X | 6 |
Epithelium, Hyperplasia | 2 2 1 | 3 1.7|
Epithelium, Metaplasia, Squamous | 2 | 2 2.0|
Glands, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 2 2 | 11 1.5|
Inflammation, Granulomatous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 3 1.7|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 3 |
Inflammation, Suppurative | 2 | 4 2.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 2.5|
Respiratory Epithelium, Hyperplasia | | 1 4.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 5| 4| 7| 4| 3| 3| 3| 3| 6| 8| 9| 3| 3| 7| 9| 9| 2| 6| 9| 3| 0| 3| 9| 3| 3| |
| 9| 7| 5| 9| 5| 5| 4| 4| 0| 7| 7| 4| 4| 7| 7| 7| 7| 7| 9| 3| 5| 5| 9| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 1 1 2 2 2 2 3 3 2 1 2 2 3 2 2 1 1 2 2| 43 2.0|
Renal Tubule, Degeneration | 2 | 1 2.0|
Renal Tubule, Mineralization | 1 2 1 2 2 1 1 2 2 2 2 1 2 2 2 2 1 2 3 2 2 2 2 2 2| 50 1.8|
Renal Tubule, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7| 7| 5| 5| 7| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 4| 9| 3| 9| 3| 3| 2| 3| 1| 3| 3| 4| 9| 3| 9| 4| 3| 3| 3| 3| 3| 0|
| 1| 3| 4| 3| 1| 4| 9| 4| 2| 3| 3| 4| 5| 4| 9| 7| 4| 8| 6| 3| 5| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + A + + + + + + + + + +|
Parasite Metazoan | X X X X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + A + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | |
Hepatodiaphragmatic Nodule | X X X X X X |
Vacuolization Cytoplasmic | 4 4 |
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Necrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Granulomatous | 4 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia | 3 3 |
Inflammation, Suppurative | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Endocardium, Atrium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 3 2 2 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7| 7| 5| 5| 7| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 4| 9| 3| 9| 3| 3| 2| 3| 1| 3| 3| 4| 9| 3| 9| 4| 3| 3| 3| 3| 3| 0|
| 1| 3| 4| 3| 1| 4| 9| 4| 2| 3| 3| 4| 5| 4| 9| 7| 4| 8| 6| 3| 5| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 3 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + M + + + + + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 2 |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Inflammation, Chronic | 2 3 3 |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 4 |
Myelofibrosis | 2 3 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + + + + + + + + + M|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + M + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + M + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7| 7| 5| 5| 7| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 4| 9| 3| 9| 3| 3| 2| 3| 1| 3| 3| 4| 9| 3| 9| 4| 3| 3| 3| 3| 3| 0|
| 1| 3| 4| 3| 1| 4| 9| 4| 2| 3| 3| 4| 5| 4| 9| 7| 4| 8| 6| 3| 5| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 4 3 2 |
Meninges, Hyperplasia | 1 |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + I + + + + + + + + + + + A + + + + + + + + + +|
Foreign Body | X X X X |
Inflammation, Suppurative | 2 |
Epithelium, Hyperplasia | 2 2 2 |
Epithelium, Metaplasia, Squamous | 2 2 2 1 |
Glands, Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 1 1 2 2 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 3 3 2|
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2|
Olfactory Epithelium, Metaplasia, | |
Squamous | 1 |
Respiratory Epithelium, Hyperplasia | 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7| 7| 5| 5| 7| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 4| 9| 3| 9| 3| 3| 2| 3| 1| 3| 3| 4| 9| 3| 9| 4| 3| 3| 3| 3| 3| 0|
| 1| 3| 4| 3| 1| 4| 9| 4| 2| 3| 3| 4| 5| 4| 9| 7| 4| 8| 6| 3| 5| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1800 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 2 |
Bilateral, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 3 3 2 2 1 1 2 1 2 2 2 3 1 2 2 2 2 1 4 2 2 2|
Renal Tubule, Mineralization | 2 2 2 2 2 2 1 3 2 1 2 2 2 1 2 1 3 2 2 2 2 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 8| 3| 2| 9| 2| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 1| 3| 3| |
| 1| 3| 8| 5| 0| 1| 9| 4| 5| 4| 4| 8| 3| 3| 1| 0| 3| 5| 4| 3| 4| 3| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + A + + + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + A + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + A + + + + + + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | X X X| 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A + A + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + A + A + + + + + + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 6 |
Clear Cell Focus | X X | 6 |
Degeneration, Cystic | 2 3 | 2 2.5|
Hepatodiaphragmatic Nodule | X X X X | 10 |
Vacuolization Cytoplasmic | 2 | 3 3.3|
Bile Duct, Hyperplasia | | 1 3.0|
Hepatocyte, Necrosis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Inflammation, Granulomatous | | 1 4.0|
Fat, Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 1 3 1 | 7 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 3 | 1 3.0|
Hyperplasia | 2 | 3 2.7|
Inflammation, Suppurative | 3 | 2 3.0|
Ulcer | 4 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Endocardium, Atrium, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 8| 3| 2| 9| 2| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 1| 3| 3| |
| 1| 3| 8| 5| 0| 1| 9| 4| 5| 4| 4| 8| 3| 3| 1| 0| 3| 5| 4| 3| 4| 3| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 3 2 4 3 2 2| 11 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M + + + + M + + + + + M + + + + + +| 42 |
Hyperplasia | 2 3| 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 2 | 6 3.0|
Pars Distalis, Hyperplasia | 2 | 2 2.0|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia | 2 3 2 2 2 4| 10 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | | 3 2.7|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4 4 | 4 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | | 1 4.0|
Myelofibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + M + M + + + +| 45 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + M M + + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 8| 3| 2| 9| 2| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 1| 3| 3| |
| 1| 3| 8| 5| 0| 1| 9| 4| 5| 4| 4| 8| 3| 3| 1| 0| 3| 5| 4| 3| 4| 3| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + M + M M + + +| 46 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 4 3 | 3 3.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Necrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 5 2.6|
Meninges, Hyperplasia | | 1 1.0|
Ventricle, Hydrocephalus | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | X X X | 7 |
Inflammation, Suppurative | | 1 2.0|
Epithelium, Hyperplasia | 2 3 2 2 2 | 8 2.1|
Epithelium, Metaplasia, Squamous | 3 | 5 2.0|
Glands, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 2 1 | 10 1.6|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 3 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 8| 3| 2| 9| 2| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 1| 3| 3| |
| 1| 3| 8| 5| 0| 1| 9| 4| 5| 4| 4| 8| 3| 3| 1| 0| 3| 5| 4| 3| 4| 3| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1800 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | | 2 |
Inflammation, Suppurative | | 3 2.7|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 4 | 2 3.0|
Bilateral, Cataract | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Nephropathy, Chronic | 2 2 2 2 2 2 1 2 2 3 1 2 2 3 2 1 1 2 3 2| 42 2.0|
Renal Tubule, Mineralization | 2 2 2 3 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 1 2 2 2| 46 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 6| 4| 7| 7| 6| 7| 4| 2| 4| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 6| 4| 7| 3| 3| 6| 2| 4| 2| 0| 2| 3| 3| 5| 4| 0| 1| 4| 2| 6| 2|
| 3| 4| 3| 5| 1| 7| 3| 3| 5| 0| 6| 9| 2| 5| 9| 5| 5| 3| 4| 6| 4| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Cystic | 2 2 3 2|
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | |
Vacuolization Cytoplasmic | 4 2 |
Bile Duct, Hyperplasia | 4 3 3 3|
Hepatocyte, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Artery, Inflammation, Chronic | 4 |
Fat, Hemorrhage | 3 1 |
Fat, Inflammation, Granulomatous | 4 3 4 |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Oral Mucosa | + + |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 |
Ulcer | 3 |
Gingival, Cyst | |
Gingival, Foreign Body | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 2 2 2 2 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperkeratosis | 3 3 2 2 |
Hyperplasia | 4 2 3 3 3 2 |
Inflammation, Suppurative | 4 3 |
Mineralization | |
Ulcer | 4 4 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 3 |
Mineralization | 4 3 1 3|
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 6| 4| 7| 7| 6| 7| 4| 2| 4| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 6| 4| 7| 3| 3| 6| 2| 4| 2| 0| 2| 3| 3| 5| 4| 0| 1| 4| 2| 6| 2|
| 3| 4| 3| 5| 1| 7| 3| 3| 5| 0| 6| 9| 2| 5| 9| 5| 5| 3| 4| 6| 4| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 2 1 2 |
Mineralization | 4 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Vacuolization Cytoplasmic | 2 3 2 1 3 4 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + I + + + + + +|
Hyperplasia | 3 4 1 2 3 1 4 4 3 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M + + + + + + + + + M + + + +|
Hyperplasia | 4 3 4|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | 1 4 4 4 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 3 |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 6| 4| 7| 7| 6| 7| 4| 2| 4| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 6| 4| 7| 3| 3| 6| 2| 4| 2| 0| 2| 3| 3| 5| 4| 0| 1| 4| 2| 6| 2|
| 3| 4| 3| 5| 1| 7| 3| 3| 5| 0| 6| 9| 2| 5| 9| 5| 5| 3| 4| 6| 4| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Artery, Inflammation | 3 |
Germinal Epithelium, Atrophy | 4 4 4 4 3 4 |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Iliac, Pigmentation | |
Lumbar, Pigmentation | |
Renal, Ectasia | 3 |
Renal, Hemorrhage | 1 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 4 3 2 2 2 3|
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 4 |
Hyperplasia | 3 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 4 |
Ulcer | 2 |
Epidermis, Cyst | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 6| 4| 7| 7| 6| 7| 4| 2| 4| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 6| 4| 7| 3| 3| 6| 2| 4| 2| 0| 2| 3| 3| 5| 4| 0| 1| 4| 2| 6| 2|
| 3| 4| 3| 5| 1| 7| 3| 3| 5| 0| 6| 9| 2| 5| 9| 5| 5| 3| 4| 6| 4| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Maxilla, Fracture | |
Turbinate, Maxilla, Hemorrhage | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Hemorrhage | 2 1 3 1 1 |
Hydrocephalus | 4 |
Mineralization | |
Necrosis | 4 |
Meninges, Hyperplasia | 3 |
Ventricle, Hydrocephalus | 3 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 2 3 |
Epithelium, Hyperplasia | |
Epithelium, Metaplasia, Squamous | |
Glands, Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 2 2 1 1 1 2|
Alveolar Epithelium, Fibrosis | 2 |
Alveolar Epithelium, Hyperplasia | 3 1 1 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 3 2 2 2 2 |
Artery, Infiltration Cellular, | |
Histiocyte | 3 |
Artery, Mineralization | |
Mediastinum, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Hemorrhage | |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 3 3 3 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Respiratory Epithelium, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 6| 4| 7| 7| 6| 7| 4| 2| 4| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 6| 4| 7| 3| 3| 6| 2| 4| 2| 0| 2| 3| 3| 5| 4| 0| 1| 4| 2| 6| 2|
| 3| 4| 3| 5| 1| 7| 3| 3| 5| 0| 6| 9| 2| 5| 9| 5| 5| 3| 4| 6| 4| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Pleura | + |
Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Fibrosis | |
Nephropathy, Chronic | 4 4 3 3 2 3 2 4 4 2 3 1 1 4 4 4 4 1 1 2 4 2 2 4|
Thrombosis | |
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 2 1 1 2 2 1 2 2 1|
Renal Tubule, Degeneration | 4 |
Renal Tubule, Hyperplasia | 4 3 4|
Renal Tubule, Inflammation, | |
Suppurative | |
Renal Tubule, Mineralization | 1 4 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Suppurative | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 0| 5| 5| 6| 7| 7| 5| 7| 7| 6| 7| 5| 5| 6| 6| 7| 6| 5| |
DAY ON TEST | 0| 3| 6| 3| 5| 2| 3| 7| 4| 6| 7| 3| 3| 8| 2| 3| 8| 3| 0| 4| 2| 6| 3| 8| 5| |
| 2| 5| 3| 3| 1| 9| 9| 3| 9| 2| 3| 4| 4| 7| 3| 5| 3| 3| 8| 6| 1| 3| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 4 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Degeneration, Cystic | 3 2 2 2 2 | 9 2.2|
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Granulomatous | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 3 | 4 3.0|
Bile Duct, Hyperplasia | 3 3 3| 7 3.1|
Hepatocyte, Necrosis | 4 2 | 3 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 15 |
Artery, Inflammation, Chronic | | 1 4.0|
Fat, Hemorrhage | 4 | 3 2.7|
Fat, Inflammation, Granulomatous | 3 3 | 5 3.4|
Fat, Necrosis | 2 3 3 4 3 | 8 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Ulcer | | 1 3.0|
Gingival, Cyst | 4 | 1 4.0|
Gingival, Foreign Body | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 1 2 2 3 2 2 2 | 18 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Hyperkeratosis | 3 | 5 2.6|
Hyperplasia | 2 3 4 3 | 10 2.9|
Inflammation, Suppurative | 3 | 3 3.3|
Mineralization | 2 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 0| 5| 5| 6| 7| 7| 5| 7| 7| 6| 7| 5| 5| 6| 6| 7| 6| 5| |
DAY ON TEST | 0| 3| 6| 3| 5| 2| 3| 7| 4| 6| 7| 3| 3| 8| 2| 3| 8| 3| 0| 4| 2| 6| 3| 8| 5| |
| 2| 5| 3| 3| 1| 9| 9| 3| 9| 2| 3| 4| 4| 7| 3| 5| 3| 3| 8| 6| 1| 3| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 4 4 | 6 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 3.5|
Mineralization | 4 4 3 | 7 3.1|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Mineralization | 4 | 3 4.0|
Aorta, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 4 | 8 2.1|
Mineralization | 3 4 | 3 3.7|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Vacuolization Cytoplasmic | 2 3 2 2 2 1 4 | 14 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 4 4 3 3 2 2 2 4 2| 21 2.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 46 |
Hyperplasia | 4 4 3 3 | 7 3.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 5 3.4|
Hemorrhage | 4 | 2 4.0|
Pars Distalis, Hyperplasia | 4 | 1 4.0|
Pars Intermedia, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1| 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + | 2 |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 0| 5| 5| 6| 7| 7| 5| 7| 7| 6| 7| 5| 5| 6| 6| 7| 6| 5| |
DAY ON TEST | 0| 3| 6| 3| 5| 2| 3| 7| 4| 6| 7| 3| 3| 8| 2| 3| 8| 3| 0| 4| 2| 6| 3| 8| 5| |
| 2| 5| 3| 3| 1| 9| 9| 3| 9| 2| 3| 4| 4| 7| 3| 5| 3| 3| 8| 6| 1| 3| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 2 2.5|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 4 4 | 6 3.2|
Epithelium, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Artery, Inflammation | 3 | 2 3.0|
Germinal Epithelium, Atrophy | 4 3 4 4 4 | 11 3.8|
Interstitial Cell, Hyperplasia | 1 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 16 |
Iliac, Pigmentation | 2 | 1 2.0|
Lumbar, Pigmentation | 3 | 1 3.0|
Renal, Ectasia | | 1 3.0|
Renal, Hemorrhage | | 1 1.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + + + + + + + + + + M + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + M + + M + M + +| 46 |
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X X| 3 |
Fibrosis | 4 3 4 3 3 3 4 3 | 14 3.1|
Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 0| 5| 5| 6| 7| 7| 5| 7| 7| 6| 7| 5| 5| 6| 6| 7| 6| 5| |
DAY ON TEST | 0| 3| 6| 3| 5| 2| 3| 7| 4| 6| 7| 3| 3| 8| 2| 3| 8| 3| 0| 4| 2| 6| 3| 8| 5| |
| 2| 5| 3| 3| 1| 9| 9| 3| 9| 2| 3| 4| 4| 7| 3| 5| 3| 3| 8| 6| 1| 3| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 4 4 | 5 3.2|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 4 4 | 5 4.0|
Hyperplasia | 4 4 | 3 3.7|
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | 3 4 4 3 | 5 3.6|
Ulcer | 2 4 3 | 4 2.8|
Epidermis, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Turbinate, Maxilla, Fracture | X | 1 |
Turbinate, Maxilla, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | | 1 |
Hemorrhage | 1 1 3 | 8 1.6|
Hydrocephalus | | 1 4.0|
Mineralization | 1 | 1 1.0|
Necrosis | | 1 4.0|
Meninges, Hyperplasia | | 1 3.0|
Ventricle, Hydrocephalus | 3 2 4 2 3 | 7 2.9|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 3 |
Inflammation, Suppurative | 2 | 3 2.3|
Epithelium, Hyperplasia | 2 | 1 2.0|
Epithelium, Metaplasia, Squamous | 2 3 | 2 2.5|
Glands, Inflammation, Suppurative | 3 2 1 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 0| 5| 5| 6| 7| 7| 5| 7| 7| 6| 7| 5| 5| 6| 6| 7| 6| 5| |
DAY ON TEST | 0| 3| 6| 3| 5| 2| 3| 7| 4| 6| 7| 3| 3| 8| 2| 3| 8| 3| 0| 4| 2| 6| 3| 8| 5| |
| 2| 5| 3| 3| 1| 9| 9| 3| 9| 2| 3| 4| 4| 7| 3| 5| 3| 3| 8| 6| 1| 3| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 1 1 2 1 1 2 | 16 1.6|
Alveolar Epithelium, Fibrosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 1.7|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 3 2 | 7 2.3|
Artery, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Artery, Mineralization | 4 4 | 2 4.0|
Mediastinum, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X | 6 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 1 2 2 | 8 2.3|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | 3 1 | 3 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 | 3 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pleura | + | 2 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 1 | 3 3.0|
Fibrosis | 3 | 1 3.0|
Nephropathy, Chronic | 3 4 4 4 3 4 2 2 3 2 3 4 3 4 4 4 4 1 2 4 3 4 3 2| 48 3.0|
Thrombosis | 3 | 1 3.0|
Pelvis, Dilatation | 4 4 | 2 4.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 3 1 3 3 2 | 16 1.9|
Renal Tubule, Degeneration | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 0| 5| 5| 6| 7| 7| 5| 7| 7| 6| 7| 5| 5| 6| 6| 7| 6| 5| |
DAY ON TEST | 0| 3| 6| 3| 5| 2| 3| 7| 4| 6| 7| 3| 3| 8| 2| 3| 8| 3| 0| 4| 2| 6| 3| 8| 5| |
| 2| 5| 3| 3| 1| 9| 9| 3| 9| 2| 3| 4| 4| 7| 3| 5| 3| 3| 8| 6| 1| 3| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia | 4 4 2 3 | 7 3.4|
Renal Tubule, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Renal Tubule, Mineralization | 2 1 4 4 4 | 8 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 2 4.0|
Inflammation, Suppurative | 4 2 | 2 3.0|
Transitional Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 5| 5| 6| 7| 5| 6| 6| 5| 7| 5| 6| 5| 4| 5| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 5| 6| 5| 7| 3| 0| 5| 6| 0| 5| 3| 1| 4| 4| 3| 7| 2| 1| 0| 0| 2|
| 9| 5| 9| 4| 9| 0| 1| 9| 9| 1| 2| 0| 7| 1| 5| 4| 6| 0| 9| 5| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Basophilic Focus | X |
Clear Cell Focus | X |
Degeneration, Cystic | 4 3 4 |
Hepatodiaphragmatic Nodule | |
Vacuolization Cytoplasmic | 4 |
Bile Duct, Hyperplasia | 3 3 2 3 3|
Hepatocyte, Necrosis | 3 |
Serosa, Fibrosis | |
Serosa, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Fat, Inflammation, Granulomatous | |
Fat, Mineralization | 2 |
Fat, Necrosis | 2 3 3 2 3 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 1 1 2 2 |
Artery, Inflammation, Granulomatous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Hyperplasia | 3 4 3 3 2 |
Inflammation, Suppurative | |
Ulcer | 2 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Tooth | + M |
Developmental Malformation | X |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 5| 5| 6| 7| 5| 6| 6| 5| 7| 5| 6| 5| 4| 5| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 5| 6| 5| 7| 3| 0| 5| 6| 0| 5| 3| 1| 4| 4| 3| 7| 2| 1| 0| 0| 2|
| 9| 5| 9| 4| 9| 0| 1| 9| 9| 1| 2| 0| 7| 1| 5| 4| 6| 0| 9| 5| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 |
Atrium, Thrombosis | 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 2 3 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 4 4 4 2 1 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + I + + + +|
Cyst | 4 3 |
Hemorrhage | 4 4 |
Craniopharyngeal Duct, Cyst | 4 |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 4 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 3 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Tubular | |
Inflammation, Granulomatous | 3 |
Spermatocele | |
Artery, Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | 3 |
Germinal Epithelium, Atrophy | 1 3 4 |
Interstitial Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 5| 5| 6| 7| 5| 6| 6| 5| 7| 5| 6| 5| 4| 5| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 5| 6| 5| 7| 3| 0| 5| 6| 0| 5| 3| 1| 4| 4| 3| 7| 2| 1| 0| 0| 2|
| 9| 5| 9| 4| 9| 0| 1| 9| 9| 1| 2| 0| 7| 1| 5| 4| 6| 0| 9| 5| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Pancreatic, Hyperplasia, Histiocytic | 2 |
Renal, Ectasia | 2 |
Renal, Fibrosis | 3 |
Renal, Hemorrhage | 3 |
Renal, Hyperplasia, Histiocytic | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + + M + + + + + M + + +|
Fibrosis | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 4 3 4 3 4 4|
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | 3|
Epidermis, Cyst | 3 |
Subcutaneous Tissue, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Demyelination | 3 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 5| 5| 6| 7| 5| 6| 6| 5| 7| 5| 6| 5| 4| 5| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 5| 6| 5| 7| 3| 0| 5| 6| 0| 5| 3| 1| 4| 4| 3| 7| 2| 1| 0| 0| 2|
| 9| 5| 9| 4| 9| 0| 1| 9| 9| 1| 2| 0| 7| 1| 5| 4| 6| 0| 9| 5| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 4 1 3 |
Hydrocephalus | 4 |
Ventricle, Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 3 |
Epithelium, Hyperplasia | 2|
Glands, Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 1 1 1 1 1 |
Alveolar Epithelium, Fibrosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 2 |
Bronchiole, Metaplasia, Squamous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | |
Inflammation, Suppurative | |
Glands, Dilatation, Focal | |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Pleura | |
Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 |
Nephropathy, Chronic | 2 4 3 2 1 4 2 3 4 3 2 2 3 3 4 2 3 2 2 2 2 4 3 2 2|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 1 1 1 1 |
Pelvis, Transitional Epithelium, | |
Inflammation, Suppurative | |
Renal Tubule, Hyperplasia | 3 4 |
Renal Tubule, Mineralization | 1 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 5| 5| 6| 7| 5| 6| 6| 5| 7| 5| 6| 5| 4| 5| 6| 7| 6| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 5| 6| 5| 7| 3| 0| 5| 6| 0| 5| 3| 1| 4| 4| 3| 7| 2| 1| 0| 0| 2|
| 9| 5| 9| 4| 9| 0| 1| 9| 9| 1| 2| 0| 7| 1| 5| 4| 6| 0| 9| 5| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Suppurative | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 5| 6| 5| 7| 6| 5| 5| |
DAY ON TEST | 4| 5| 3| 9| 1| 1| 2| 7| 3| 3| 3| 1| 7| 1| 2| 1| 7| 2| 2| 4| 5| 0| 3| 0| 1| |
| 0| 3| 0| 1| 4| 9| 6| 2| 5| 5| 3| 9| 5| 5| 9| 9| 7| 3| 8| 3| 1| 7| 5| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 4 1 4 | 6 2.7|
Basophilic Focus | | 1 |
Clear Cell Focus | X | 2 |
Degeneration, Cystic | 4 3 3 | 6 3.5|
Hepatodiaphragmatic Nodule | X X | 2 |
Vacuolization Cytoplasmic | 2 4| 3 3.3|
Bile Duct, Hyperplasia | 4 3 | 7 3.0|
Hepatocyte, Necrosis | 4 | 2 3.5|
Serosa, Fibrosis | 3 | 1 3.0|
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 17 |
Fat, Inflammation, Granulomatous | 3 | 1 3.0|
Fat, Mineralization | | 1 2.0|
Fat, Necrosis | 3 3 3 3 1 3 3 3 | 15 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 2 2 | 11 1.8|
Artery, Inflammation, Granulomatous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 4 | 2 3.5|
Hyperplasia | 3 3 3 3 4 2 3 4 3| 14 3.1|
Inflammation, Suppurative | 3| 1 3.0|
Ulcer | 3 4 4 4 3 4 4 | 10 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
Ulcer | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Developmental Malformation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 5| 6| 5| 7| 6| 5| 5| |
DAY ON TEST | 4| 5| 3| 9| 1| 1| 2| 7| 3| 3| 3| 1| 7| 1| 2| 1| 7| 2| 2| 4| 5| 0| 3| 0| 1| |
| 0| 3| 0| 1| 4| 9| 6| 2| 5| 5| 3| 9| 5| 5| 9| 9| 7| 3| 8| 3| 1| 7| 5| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 1 | 6 1.8|
Atrium, Thrombosis | 3 3 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 3 2 2| 8 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 2 3 4 4 3 3 4 | 19 3.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + M + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 | 5 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 4 2 4 | 6 3.3|
Hemorrhage | 4 | 3 4.0|
Craniopharyngeal Duct, Cyst | | 1 4.0|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | | 3 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 2 |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Tubular | 3 | 1 3.0|
Inflammation, Granulomatous | | 1 3.0|
Spermatocele | 4 | 1 4.0|
Artery, Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 5| 6| 5| 7| 6| 5| 5| |
DAY ON TEST | 4| 5| 3| 9| 1| 1| 2| 7| 3| 3| 3| 1| 7| 1| 2| 1| 7| 2| 2| 4| 5| 0| 3| 0| 1| |
| 0| 3| 0| 1| 4| 9| 6| 2| 5| 5| 3| 9| 5| 5| 9| 9| 7| 3| 8| 3| 1| 7| 5| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 4| 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 3 2 | 5 2.8|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation | 3 | 2 3.0|
Germinal Epithelium, Atrophy | 3 2 3 4| 7 2.9|
Interstitial Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 19 |
Pancreatic, Hyperplasia, Histiocytic | | 1 2.0|
Renal, Ectasia | 3 3 | 3 2.7|
Renal, Fibrosis | | 1 3.0|
Renal, Hemorrhage | 2 | 2 2.5|
Renal, Hyperplasia, Histiocytic | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + + + + M| 45 |
Fibrosis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 4 2 3 3 4 | 13 3.5|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 5| 6| 5| 7| 6| 5| 5| |
DAY ON TEST | 4| 5| 3| 9| 1| 1| 2| 7| 3| 3| 3| 1| 7| 1| 2| 1| 7| 2| 2| 4| 5| 0| 3| 0| 1| |
| 0| 3| 0| 1| 4| 9| 6| 2| 5| 5| 3| 9| 5| 5| 9| 9| 7| 3| 8| 3| 1| 7| 5| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4| 1 4.0|
Ulcer | | 1 3.0|
Epidermis, Cyst | 4 4 | 3 3.7|
Subcutaneous Tissue, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Demyelination | | 1 3.0|
Hemorrhage | 4 1| 5 2.6|
Hydrocephalus | | 1 4.0|
Ventricle, Hydrocephalus | 2 3 3 3 3 3| 7 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X X X X| 5 |
Inflammation, Suppurative | | 1 3.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
Glands, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 2 3 1| 12 1.4|
Alveolar Epithelium, Fibrosis | 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 3 2 2 | 4 2.3|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 3 3 2 3 3 3 | 7 2.7|
Bronchiole, Metaplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X X X | 3 |
Hemorrhage | 2| 1 2.0|
Inflammation, Suppurative | 3 2 | 2 2.5|
Glands, Dilatation, Focal | 4 | 1 4.0|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 5| 6| 5| 7| 6| 5| 5| |
DAY ON TEST | 4| 5| 3| 9| 1| 1| 2| 7| 3| 3| 3| 1| 7| 1| 2| 1| 7| 2| 2| 4| 5| 0| 3| 0| 1| |
| 0| 3| 0| 1| 4| 9| 6| 2| 5| 5| 3| 9| 5| 5| 9| 9| 7| 3| 8| 3| 1| 7| 5| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Pleura | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 3 3.7|
Nephropathy, Chronic | 4 2 2 2 4 4 3 1 4 2 4 4 4 2 4 4 4 2 2 1 4 4 4 2 4| 50 2.9|
Pelvis, Dilatation | 3 | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 2 1 2 2 2 2 4 | 13 1.8|
Pelvis, Transitional Epithelium, | | |
Inflammation, Suppurative | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 4 3 4 | 5 3.6|
Renal Tubule, Mineralization | 1 1 2 | 7 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 5| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 6| 2| 6| 6| 5| 6| 5|
DAY ON TEST | 1| 1| 1| 3| 2| 2| 5| 3| 7| 3| 4| 3| 9| 7| 2| 1| 4| 7| 3| 7| 3| 2| 9| 1| 6|
| 1| 9| 4| 5| 9| 2| 1| 1| 3| 5| 4| 4| 1| 3| 3| 7| 6| 7| 5| 5| 9| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
Muscularis, Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Necrosis | |
Parasite Metazoan | X X |
Artery, Inflammation, Granulomatous | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + A + + + + +|
Peyer's Patch, Hyperplasia | 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Basophilic Focus | |
Clear Cell Focus | X X |
Degeneration, Cystic | 4 4 3 4 4 3 |
Eosinophilic Focus | |
Vacuolization Cytoplasmic | 4 2 2 2 3|
Bile Duct, Hyperplasia | 3 2 4 |
Hepatocyte, Necrosis | 1 3 |
Hepatocyte, Regeneration | |
Periportal, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Fat, Inflammation, Granulomatous | 4 |
Fat, Mineralization | 3 |
Fat, Necrosis | 3 4 2 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 3 2 2|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 2 |
Hyperplasia | 2 3 |
Inflammation, Suppurative | 4 3 |
Mineralization | 4 |
Necrosis | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Metaplasia, Squamous | |
Mineralization | 4 4 3 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 5| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 6| 2| 6| 6| 5| 6| 5|
DAY ON TEST | 1| 1| 1| 3| 2| 2| 5| 3| 7| 3| 4| 3| 9| 7| 2| 1| 4| 7| 3| 7| 3| 2| 9| 1| 6|
| 1| 9| 4| 5| 9| 2| 1| 1| 3| 5| 4| 4| 1| 3| 3| 7| 6| 7| 5| 5| 9| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 |
Mineralization | 3 4 |
Atrium, Thrombosis | 3 4 |
Endocardium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 3 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 4 2 4 4 4 4 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 4 3 4 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + M + + + + + + + + + + +|
Cyst | 4 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 4 |
Inflammation, Suppurative | 4 4 3 3 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 5| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 6| 2| 6| 6| 5| 6| 5|
DAY ON TEST | 1| 1| 1| 3| 2| 2| 5| 3| 7| 3| 4| 3| 9| 7| 2| 1| 4| 7| 3| 7| 3| 2| 9| 1| 6|
| 1| 9| 4| 5| 9| 2| 1| 1| 3| 5| 4| 4| 1| 3| 3| 7| 6| 7| 5| 5| 9| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Granulomatous | |
Artery, Inflammation | |
Germinal Epithelium, Atrophy | 4 3 4 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Inflammation, Suppurative | 4 |
Renal, Hyperplasia, Histiocytic | |
Renal, Deep Cervical, Angiectasis | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + M + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 1|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + M + + M + + + + + + + M + + + + +|
Hemorrhage | 4 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X|
Fibrosis | 3 3 3 3 4 3 3 4 3 3 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + M + + + + + + + + + + + + +|
Hemorrhage | 3 1 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Necrosis | 4 |
Ulcer | 3 3 |
Epidermis, Cyst | 3 |
Subcutaneous Tissue, Hemorrhage | |
Subcutaneous Tissue, Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Femur, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 5| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 6| 2| 6| 6| 5| 6| 5|
DAY ON TEST | 1| 1| 1| 3| 2| 2| 5| 3| 7| 3| 4| 3| 9| 7| 2| 1| 4| 7| 3| 7| 3| 2| 9| 1| 6|
| 1| 9| 4| 5| 9| 2| 1| 1| 3| 5| 4| 4| 1| 3| 3| 7| 6| 7| 5| 5| 9| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Hemorrhage | 2 4 2 1|
Ventricle, Hydrocephalus | 4 4 3 |
__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 3 |
Epithelium, Hyperplasia | 2 |
Epithelium, Metaplasia, Squamous | 2 1 |
Glands, Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 1 1 1 2 1 2 2 1|
Alveolar Epithelium, Fibrosis | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 3 3 1|
Alveolar Epithelium, Mineralization | 3 4 |
Artery, Mineralization | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X |
Hemorrhage | 3 |
Inflammation, Suppurative | 2 3 1 2 3 1 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 2 4 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Cornea, Inflammation, Chronic | 3 |
Cornea, Mineralization | 1 4 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 5| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 6| 2| 6| 6| 5| 6| 5|
DAY ON TEST | 1| 1| 1| 3| 2| 2| 5| 3| 7| 3| 4| 3| 9| 7| 2| 1| 4| 7| 3| 7| 3| 2| 9| 1| 6|
| 1| 9| 4| 5| 9| 2| 1| 1| 3| 5| 4| 4| 1| 3| 3| 7| 6| 7| 5| 5| 9| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Nephropathy, Chronic | 4 4 4 3 4 3 2 4 4 3 2 4 4 1 2 4 4 3 4 1 4 4 2 2 4|
Thrombosis | 3 |
Cortex, Necrosis | 4 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 1 1 2 1 2 2 2 2 |
Renal Tubule, Hyperplasia | 2 1 1 |
Renal Tubule, Mineralization | 4 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05181-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/20/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:13:03
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 5| 7| 6| 6| 6| 6| 5| 7| 6| 5| 6| 6| 5| 5| 6| 6| 6| 6| 4| 5| 7| |
DAY ON TEST | 6| 0| 4| 9| 4| 3| 6| 2| 3| 3| 9| 3| 9| 4| 3| 7| 9| 7| 3| 8| 7| 4| 0| 5| 1| |
| 1| 7| 5| 7| 5| 3| 3| 6| 9| 9| 0| 5| 9| 7| 9| 3| 2| 5| 1| 0| 7| 2| 1| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X | 4 |
Muscularis, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Necrosis | 4 | 1 4.0|
Parasite Metazoan | X X | 4 |
Artery, Inflammation, Granulomatous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 3 3.3|
Basophilic Focus | X | 1 |
Clear Cell Focus | | 2 |
Degeneration, Cystic | 3 2 2| 9 3.2|
Eosinophilic Focus | X | 1 |
Vacuolization Cytoplasmic | 3 3 | 7 2.7|
Bile Duct, Hyperplasia | 3 3 3 | 6 3.0|
Hepatocyte, Necrosis | | 2 2.0|
Hepatocyte, Regeneration | 3 | 1 3.0|
Periportal, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 18 |
Fat, Inflammation, Granulomatous | 3 | 2 3.5|
Fat, Mineralization | 3 | 2 3.0|
Fat, Necrosis | 3 3 2 3 3 | 12 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 | 7 2.1|
Artery, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
___________________________________________________________