TDMS Study 05181-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/20/96
EXPERIMENT: 05181 TEST: 03 TIME: 16:36:08
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. RENNE CAS: 0109-99-9
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/20/96
EXPERIMENT: 05181 TEST: 03 TIME: 16:36:08
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. RENNE CAS: 0109-99-9
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 1 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 244 406 422 453 508 514 526 546 547 549 |
| 551 554 562 563 563 573 575 587 602 621 |
| 621 635 635 639 649 649 660 661 663 673 |
| 683 683 705 723 729 729 729 |
| CENSORED DEATHS |
| 73 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 43 CENSORED DEATHS 1 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 439 502 503 514 514 519 523 528 540 540 |
| 551 551 551 552 575 575 579 607 607 614 |
| 624 626 629 630 635 639 639 643 646 653 |
| 660 660 672 677 691 701 707 715 719 719 |
| 719 729 729 |
| CENSORED DEATHS |
| 559 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 45 CENSORED DEATHS 0 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 275 401 517 531 544 545 547 551 558 561 |
| 561 575 590 591 591 592 597 614 621 622 |
| 626 629 631 635 639 639 639 639 642 645 |
| 646 663 673 673 673 677 677 680 699 707 |
| 711 714 715 719 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1800 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 44 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 417 431 447 463 488 505 511 516 546 548 |
| 551 562 566 572 583 594 596 597 597 597 |
| 607 635 635 644 645 651 656 657 660 667 |
| 668 677 678 680 686 689 699 704 710 714 |
| 719 719 727 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 93.9 91.8 85.7 61.2 40.8 24.5 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 80.0 65.8 35.0 12.3 |
| | |
| | |
|600 PPM | 100.0 100.0 100.0 98.0 96.0 96.0 88.0 66.0 36.0 10.0 |
| | |
| | |
|1800 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 84.0 60.0 42.0 12.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 200 PPM 600 PPM 1800 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 24.5% 12.3% 10.0% 12.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.538 P=0.290 P=0.204 P=0.330 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 592.8 612.7 615.5 612.4 |
|NATURAL DEATHS (C) | (16.7) (11.5) (12.5) (12.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 616.0 626.1 627.3 626.8 |
|(STANDARD ERROR) | (18.6) (11.5) (12.3) (12.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 4 140 411 467 520 523 537 547 563 597 |
| 634 642 643 657 663 667 672 678 701 705 |
| 705 710 714 715 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 58 336 467 478 491 500 505 565 592 614 |
| 624 651 658 670 681 681 681 687 695 705 |
| 705 714 719 719 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 519 538 547 559 569 575 597 597 597 607 |
| 626 649 649 660 663 667 674 677 683 687 |
| 699 699 705 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1800 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 412 420 478 498 523 532 549 575 588 597 |
| 624 629 630 634 641 643 646 661 691 691 |
| 691 699 705 714 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 96.0 96.0 96.0 94.0 92.0 86.0 80.0 70.0 50.0 |
| | |
| | |
|200 PPM | 98.0 98.0 98.0 96.0 96.0 92.0 86.0 82.0 74.0 50.0 |
| | |
| | |
|600 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 82.0 70.0 52.0 |
| | |
| | |
|1800 PPM | 100.0 100.0 100.0 100.0 96.0 94.0 88.0 80.0 64.0 52.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 200 PPM 600 PPM 1800 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.0% 50.0% 52.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=1.000N P=0.939N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 581.3 596.6 632.1 603.0 |
|NATURAL DEATHS (C) | (35.2) (30.4) (12.2) (18.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 657.2 664.8 684.6 670.6 |
|(STANDARD ERROR) | (20.5) (17.9) ( 9.2) (12.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TETRAHYDROFURAN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
200 PPM = 2
600 PPM = 3
1800 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 4 2
| 1 3 1 4 42 2
| 1 14 4 1 4 2 2 3
| 1 4 4 1 3 3
90 + 4 11 2
| 1 1 33
| 44 21 133
| 1133
80 + 22
| 113 3
P | 1143 3
E | 2 424
R 70 + 11 4 4
C | 11 33
E | 11 3233
N | 1 122
T 60 + 14212
| 4 1 1
S | 334
U | 2114
R 50 + 211
V | 14 1
I | 4 4
V | 22 44
A 40 + 22 1 11
L | 3 344
| 2231 1
| 22 1 1
30 + 242 2 1 1
| 44
| 33 3242 1
| 33
20 + 334
| 2 2
| 334 4
| 33 2
10 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 54 obs hidden.
TETRAHYDROFURAN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
200 PPM = 2
600 PPM = 3
1800 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 11 2 4 3
| 1 2 1 2 44 3 3
96 + 1 2 14 2 4 3 3
| 1 1 2 4 33
P | 1 2 24 1 3 3
E | 22 44 33
R 88 + 22 141 4 3 3
C | 2 1 1 2 4
E | 1 1 44 2
N | 1 4 2132
T 80 + 132 21
| 2112
S | 22
U | 44131 32
R 72 + 44 1 12 2
V | 11
I | 44 33
V | 4 41122
A 64 + 4 13221
L | 3322
| 33
| 4411
56 + 3322
| 3113
| 4 3 3
| 1 1
48 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.