TDMS Study 05182-04 Pathology Tables
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
Facility: TSI Mason Research
Chemical CAS #: 77-09-8
Lock Date: 01/24/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 6 6 7 10
Moribund Sacrifice 5 13 9 12
Survivors
Terminal Sacrifice 38 31 34 28
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (46) (46) (44)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Colon (50) (48) (48) (48)
Intestine Large, Rectum (50) (49) (48) (49)
Intestine Large, Cecum (50) (48) (48) (45)
Fibrosarcoma 1 (2%)
Intestine Small, Duodenum (48) (47) (47) (48)
Intestine Small, Jejunum (49) (48) (46) (46)
Carcinoma 1 (2%)
Intestine Small, Ileum (48) (47) (46) (47)
Liver (50) (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma 6 (12%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 12 (24%) 2 (4%) 6 (12%) 1 (2%)
Hepatocellular Adenoma, Multiple 5 (10%)
Histiocytic Sarcoma 1 (2%) 6 (12%) 7 (14%)
Mesentery (16) (2) (7) (1)
Fibrous Histiocytoma 1 (6%)
Hemangiosarcoma 1 (14%)
Pancreas (50) (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Salivary Glands (49) (50) (50) (49)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 3 (6%)
Stomach, Glandular (50) (49) (49) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 1 (2%)
Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adrenal Medulla (50) (50) (50) (50)
Islets, Pancreatic (49) (50) (50) (50)
Adenoma 1 (2%)
Pituitary Gland (49) (50) (49) (48)
Pars Distalis, Adenoma 3 (6%) 2 (4%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (48) (48) (50)
Ovary (50) (49) (50) (50)
Cystadenoma 3 (6%) 1 (2%)
Fibrous Histiocytoma 1 (2%)
Granulosa Cell Tumor Benign 1 (2%) 1 (2%)
Hemangioma 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sex Cord Stromal Tumor, Benign 6 (12%) 6 (12%) 5 (10%)
Teratoma Benign 1 (2%)
Bilateral, Sex Cord Stromal Tumor, Benign 1 (2%)
Uterus (50) (50) (50) (50)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Polyp Stromal 1 (2%) 2 (4%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%) 5 (10%)
Lymph Node (14) (17) (13) (16)
Iliac, Fibrous Histiocytoma 1 (7%)
Iliac, Histiocytic Sarcoma 3 (19%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 2 (14%)
Mediastinal, Histiocytic Sarcoma 1 (6%)
Pancreatic, Histiocytic Sarcoma 1 (6%)
Renal, Histiocytic Sarcoma 2 (13%)
Lymph Node, Mandibular (49) (50) (49) (49)
Histiocytic Sarcoma 3 (6%) 4 (8%)
Lymph Node, Mesenteric (49) (50) (49) (50)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 3 (6%) 4 (8%)
Spleen (50) (50) (50) (50)
Hemangiosarcoma 1 (2%) 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 3 (6%) 6 (12%)
Thymus (48) (44) (49) (45)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Fibrous Histiocytoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoacanthoma 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (1) (1) (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Hemangiosarcoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%) 4 (8%) 6 (12%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 4 (8%) 4 (8%) 1 (2%) 2 (4%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Fibrous Histiocytoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 4 (8%) 4 (8%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hemangiosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Trachea (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (5) (2) (1) (2)
Adenoma 2 (40%) 1 (50%) 1 (100%) 1 (50%)
Carcinoma 2 (40%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Urinary Bladder (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 7 (14%) 7 (14%)
Lymphoma Malignant 15 (30%) 28 (56%) 33 (66%) 25 (50%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 39 47 43
Total Primary Neoplasms 70 63 75 58
Total Animals with Benign Neoplasms 26 20 23 17
Total Benign Neoplasms 33 23 25 19
Total Animals with Malignant Neoplasms 25 34 41 37
Total Malignant Neoplasms 37 40 50 39
Total Animals with Metastatic Neoplasms 3 4 3
Total Metastatic Neoplasm 7 4 4
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 6 13 11 3
Natural Death 4 4 3 10
Survivors
Terminal Sacrifice 40 33 36 36
Missing 1
Animals Examined Microscopically 50 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (49)
Gallbladder (50) (46) (46) (41)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Intestine Large, Rectum (50) (50) (50) (48)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Intestine Large, Cecum (50) (48) (47) (45)
Carcinoma 1 (2%)
Intestine Small, Duodenum (49) (48) (48) (46)
Carcinoma 1 (2%)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Jejunum (49) (49) (48) (46)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Intestine Small, Ileum (49) (50) (48) (46)
Liver (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Mesentery 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (4%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 7 (14%) 9 (18%) 4 (8%) 9 (18%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 10 (20%) 11 (22%) 8 (16%) 9 (18%)
Hepatocellular Adenoma, Multiple 12 (24%) 1 (2%) 1 (2%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 3 (6%) 10 (20%) 12 (24%)
Ito Cell Tumor Malignant 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (9) (9) (4) (3)
Fibrosarcoma 1 (11%) 1 (25%)
Page 7
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Hemangiosarcoma 2 (22%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (11%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (11%)
Pancreas (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Mesentery 1 (2%) 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 4 (8%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Salivary Glands (50) (50) (50) (49)
Hemangiosarcoma 1 (2%)
Stomach, Forestomach (50) (50) (50) (49)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%)
Stomach, Glandular (50) (50) (50) (48)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%)
Tooth (49) (50) (50) (49)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 3 (6%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (48)
Adenoma 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Capsule, Adenoma 1 (2%) 2 (4%)
Capsule, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Adrenal Medulla (49) (50) (49) (48)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 1 (2%)
Pituitary Gland (48) (50) (49) (48)
Pars Distalis, Adenoma 1 (2%)
Page 8
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (50) (50) (49)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Mesentery 1 (2%) 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (2%)
Preputial Gland (49) (50) (49) (49)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Prostate (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Seminal Vesicle (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Mesentery 1 (2%) 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Testes (50) (50) (50) (48)
Hemangiosarcoma 1 (2%)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 5 (10%) 5 (10%)
Mast Cell Tumor Malignant 1 (2%)
Lymph Node (8) (5) (14) (9)
Iliac, Fibrosarcoma, Metastatic, Mesentery 1 (20%)
Iliac, Histiocytic Sarcoma 2 (14%) 1 (11%)
Inguinal, Mast Cell Tumor Malignant,
Metastatic, Bone Marrow 1 (11%)
Mediastinal, Carcinoma, Metastatic, Kidney 1 (13%)
Mediastinal, Sarcoma, Metastatic, Uncertain
Primary Site 1 (20%)
Pancreatic, Histiocytic Sarcoma 1 (11%)
Renal, Histiocytic Sarcoma 2 (14%)
Renal, Osteosarcoma, Metastatic, Uncertain
Page 9
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Primary Site 1 (7%)
Lymph Node, Mandibular (49) (50) (49) (49)
Histiocytic Sarcoma 2 (4%) 4 (8%)
Lymph Node, Mesenteric (50) (50) (48) (49)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 2 (4%) 4 (8%) 7 (14%)
Spleen (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Hemangiosarcoma 5 (10%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 2 (4%) 6 (12%) 9 (18%)
Thymus (43) (46) (44) (42)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Histiocytic Sarcoma 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (49)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 3 (6%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma, Metastatic,
Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (48)
Carcinoma, Metastatic, Kidney 1 (2%)
Skeletal Muscle (2) (1) (1) (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (50%)
Carcinoma, Metastatic, Kidney 1 (50%)
Fibrosarcoma, Metastatic, Mesentery 1 (100%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Alveolar/Bronchiolar Adenoma 8 (16%) 10 (20%) 4 (8%) 10 (20%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (4%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 5 (10%) 4 (8%) 4 (8%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 3 (6%) 1 (2%) 3 (6%)
Histiocytic Sarcoma 2 (4%) 4 (8%) 9 (18%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Nose (50) (50) (50) (49)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Harderian Gland (3) (4) (4) (3)
Adenoma 3 (100%) 3 (75%) 2 (50%) 1 (33%)
Carcinoma 2 (50%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Histiocytic Sarcoma 2 (4%) 2 (4%) 3 (6%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
Renal Tubule, Adenoma 2 (4%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (48) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(49)
Histiocytic Sarcoma 1 (2%) 3 (6%) 11 (22%) 12 (24%)
Lymphoma Malignant 6 (12%) 8 (16%) 12 (24%) 8 (16%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 40 42 38
Total Primary Neoplasms 63 71 65 62
Total Animals with Benign Neoplasms 29 24 18 19
Total Benign Neoplasms 37 31 20 23
Total Animals with Malignant Neoplasms 19 29 35 29
Total Malignant Neoplasms 26 40 45 39
Total Animals with Metastatic Neoplasms 4 5 5 4
Total Metastatic Neoplasm 9 34 13 6
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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