TDMS Study 05182-03 Pathology Tables
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
CORE STUDY
Facility: TSI Mason Research
Chemical CAS #: 77-09-8
Lock Date: 01/24/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Acute | 2 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + A + + + + + + + + + + + +|
Edema | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X|
Fibrosis, Focal | 1|
Hematopoietic Cell Proliferation | 2 2 |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Chronic | 2 1 2 1 |
Mixed Cell Focus | X X X X X X X X X X X X X X |
Necrosis | 4 2 |
Bile Duct, Hyperplasia, Focal | 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia, Diffuse | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X |
Fat, Necrosis | 4 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 2 3 |
Acinus, Atrophy, Focal | 2 2 1 1 2 1 2 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Atrophy, Diffuse | |
Submandibular Gland, Atrophy, Diffuse| 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Erosion, Focal | 2 2 2 |
Glands, Cyst, Focal | 1 1 1 1 1|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Media, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 2 1 2 1 1 1 1 2 2 2 2 1 2|
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | 3 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | 1 1 |
Pigmentation | 2 |
Vacuolization Cytoplasmic, Focal | 1 1 4 |
Bilateral, Hyperplasia, Focal | |
Bilateral, Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 1 3 |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
Metaplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + + + + + + M + M + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | 1 2 2 1 2 1 |
Pars Distalis, Hyperplasia, Focal | 3 3 2 4 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Diffuse | 2 |
C-Cell, Hyperplasia, Focal | 2 1 2 3 2 1 1 2 1 2 2|
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic | 2 1 1 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Atrophy | 3 |
Duct, Hyperplasia, Focal | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bursa, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 1 |
Endometrium, Atrophy | 3 |
Endometrium, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 |
Myelofibrosis | 4 2 1 2 |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 2|
Hemorrhage | 1|
Hyperplasia, Lymphoid | 2 2 3 3 1 2 2 2 2 |
Infiltration Cellular, Histiocyte | 1 1 2|
Necrosis | 3 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Ectasia | 1 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 4 |
Infiltration Cellular, Histiocyte | 2 1 1 1 2 2 2 2 2 3 1 2 2 2 3 2 2 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 1 2 3 3 |
Pigmentation | 2 1 2 1|
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2|
Epithelial Cell, Hyperplasia | 2 2 2 2 1 2 2 2 1 2 1 2 1 |
Thymocyte, Atrophy | 3 3 2 4 2 3 4 4 4 4 1 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | 1 2 2 1 1 1 1 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
Femur, Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Inflammation, Chronic Active | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 1|
Interstitium, Inflammation, Chronic | 1 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 1 1|
Turbinate, Congestion | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 1 |
Lens, Cataract | 2 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization, Focal | |
Nephropathy, Chronic | 1 1 1 |
Bilateral, Mineralization, Focal | 1 1 1 1 |
Bilateral, Nephropathy, Chronic | 2 1 2 1 1 1 1 2 1 1 1 2 1 |
Bilateral, Pelvis, Dilatation | |
Bilateral, Pelvis, Inflammation, | |
Acute | |
Bilateral, Pelvis, Inflammation, | |
Chronic Active | 2 |
Bilateral, Pelvis, Transitional | |
Epithelium, Hyperplasia | 2 |
Bilateral, Renal Tubule, Pigmentation| 1 2 1 3 1 1|
Papilla, Necrosis | 3 |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3| |
| 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + A + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 1 3.0|
Inflammation, Acute | | 1 2.0|
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + A A + + + + + + + + + + + +| 45 |
Edema | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A A + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + A A A + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A A + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X| 32 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X X | 12 |
Fibrosis, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | 1 | 3 1.7|
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Chronic | 1 1 2 | 7 1.4|
Mixed Cell Focus | X X X X X X X X X X X| 25 |
Necrosis | | 2 3.0|
Bile Duct, Hyperplasia, Focal | | 1 2.0|
Centrilobular, Necrosis | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 1 2 | 3 2.3|
Kupffer Cell, Hyperplasia, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 12 |
Accessory Spleen | | 1 |
Fat, Necrosis | 2 4 2 2 2 2 2| 10 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Diffuse | 4 3 | 4 3.0|
Acinus, Atrophy, Focal | 2 1 2 1 2 3 1 2 1 | 17 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Atrophy, Diffuse | 4 3 | 2 3.5|
Submandibular Gland, Atrophy, Diffuse| | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3| |
| 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Erosion, Focal | 2 1 2 | 6 1.8|
Glands, Cyst, Focal | 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Media, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 2 3 1 1 2 1 2 2 1 1 1 2 2 2| 36 1.5|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Atrium, Thrombosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | 1 | 2 1.0|
Hypertrophy, Focal | | 2 1.0|
Pigmentation | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 3 1 | 6 2.0|
Bilateral, Hyperplasia, Focal | 2 | 1 2.0|
Bilateral, Necrosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 1 2 2| 9 1.6|
Bilateral, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Focal | 2| 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | 1 | 1 1.0|
Pars Distalis, Cyst | 2 2 2 3 2 1 1 1 | 14 1.6|
Pars Distalis, Hyperplasia, Focal | 4 | 5 3.2|
Pars Distalis, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Diffuse | | 1 2.0|
C-Cell, Hyperplasia, Focal | 1 1 2 1 1 4 2 3 3 | 20 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3| |
| 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Chronic | | 4 1.3|
Inflammation, Chronic Active | 2 3 4 | 3 3.0|
Bilateral, Atrophy | | 1 3.0|
Duct, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bursa, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 4 1.8|
Endometrium, Atrophy | | 1 3.0|
Endometrium, Inflammation, Acute | 4 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 2 2 1 1 2 | 6 1.7|
Myelofibrosis | 1 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Mediastinal, Hemorrhage | 2 | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 | 6 1.5|
Hemorrhage | 2 | 2 1.5|
Hyperplasia, Lymphoid | 2 2 2 2 1 | 14 2.0|
Infiltration Cellular, Histiocyte | 1 | 4 1.3|
Necrosis | | 1 3.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 3 | 2 3.0|
Ectasia | | 1 1.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3| |
| 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 3.5|
Infiltration Cellular, Histiocyte | 2 2 2 2 1 2 2 2 2 1 1 2 | 30 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 1 | 9 1.9|
Pigmentation | 1 1 3 1 | 8 1.5|
Lymphoid Follicle, Atrophy | 2 2 4 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Epithelial Cell, Hyperplasia | 2 2 1 2 2 1 2 | 20 1.7|
Thymocyte, Atrophy | 1 4 4 2 1 4 3 4 | 21 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 3 1 1 1 2 1 3 1 2 2 4 2 | 22 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fibrous Osteodystrophy | 2 | 1 2.0|
Femur, Hyperostosis | 2 2 4 4 3 2 | 7 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
Sciatic, Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.0|
Inflammation, Chronic Active | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 4 1.3|
Interstitium, Inflammation, Chronic | 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 1 2 | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3| |
| 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | | 3 1.0|
Turbinate, Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cornea, Inflammation, Chronic | | 1 1.0|
Lens, Cataract | | 1 2.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 2.0|
Inflammation, Acute | | 1 4.0|
Mineralization, Focal | 1 1 1 | 3 1.0|
Nephropathy, Chronic | 1 | 4 1.0|
Bilateral, Mineralization, Focal | 1 1 1 | 7 1.0|
Bilateral, Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 2 1| 30 1.2|
Bilateral, Pelvis, Dilatation | 4 | 1 4.0|
Bilateral, Pelvis, Inflammation, | | |
Acute | 2 | 1 2.0|
Bilateral, Pelvis, Inflammation, | | |
Chronic Active | | 1 2.0|
Bilateral, Pelvis, Transitional | | |
Epithelium, Hyperplasia | 1 | 2 1.5|
Bilateral, Renal Tubule, Pigmentation| 1 1 3 2 2 | 11 1.6|
Papilla, Necrosis | | 1 3.0|
Renal Tubule, Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|
| 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Cytoplasmic Alteration, Focal | 3 |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 1 2 |
Hepatodiaphragmatic Nodule | X X X X |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Chronic | 1 2 |
Mixed Cell Focus | X X X X X X X X X X X |
Hepatocyte, Vacuolization Cytoplasmic| 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Oral Mucosa | + + |
Ulcer | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 1 1 1 1 1 1 2 3 2 2 1|
Acinus, Basophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Parotid Gland, Atrophy, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
Glands, Cyst, Focal | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Tongue | + + + |
Capillary, Erosion, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|
| 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 1 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 1 1 1 2 1 2 1 2 1 |
Bilateral, Hematopoietic Cell | |
Proliferation | |
Bilateral, Hyperplasia, Focal | 2 |
Bilateral, Necrosis | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 3 2|
Infiltration Cellular, Lymphocyte | |
Bilateral, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + M + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 3 |
Pars Distalis, Cyst | 2 2 2 1 2 2 2 1 |
Pars Distalis, Hyperplasia, Focal | |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 1 1 2 1 2 1 3 2 |
Follicle, Cyst | 2 |
Follicle, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 3 2 2 |
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | |
Bilateral, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|
| 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Inflammation, Acute | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Pigmentation | |
Bursa, Cyst | 3 4 3 |
Follicle, Cyst | 2 2 |
Periovarian Tissue, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 1 4 |
Inflammation, Chronic Active | |
Necrosis | |
Endometrium, Cyst | 1 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 2 2 1 1 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 3 1 1|
Hyperplasia, Lymphoid | 2 1|
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 2 1 1 2 2 1 2 1 1 1 1 1 1 2 2 2 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 3 1 1|
Pigmentation | 1 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Epithelial Cell, Hyperplasia | 2 1 2 2 2 2 1 2 2 2 1 2 1 1 1 2 2 1 2|
Thymocyte, Atrophy | 2 2 3 3 2 3 4 2 4 3 4 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 4 1 2 2 |
Inflammation, Chronic | 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|
| 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Femur, Hyperostosis | 4 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Cerebellum, Hemorrhage, Focal | |
Cerebrum, Hemorrhage, Focal | |
Pons, Hemorrhage, Focal | 2 |
Thalamus, Cerebrum, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Interstitium, Inflammation, Chronic | 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 2 2 3 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|
| 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | |
Fibrosis, Focal | 3 |
Mineralization, Focal | 1|
Nephropathy, Chronic | 1 |
Bilateral, Mineralization, Focal | 1 1 1 |
Bilateral, Nephropathy, Chronic | 2 1 1 1 3 2 2 2 1 1 1 1 2 1 1 1 1 1 2 1 1 2|
Bilateral, Renal Tubule, Pigmentation| 1 2 1 3 1 |
Pelvis, Inflammation, Acute | 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
12000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Edema | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 2| 4 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 34 |
Clear Cell Focus | X X| 3 |
Cytoplasmic Alteration, Focal | | 1 3.0|
Eosinophilic Focus | X X X X X X X | 12 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | X X X | 7 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 1 1.0|
Inflammation, Chronic | 1 | 3 1.3|
Mixed Cell Focus | X X X X X X X X X X X X| 23 |
Hepatocyte, Vacuolization Cytoplasmic| | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Fat, Necrosis | 2 2 2 3 | 7 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Acinus, Atrophy, Diffuse | 3 | 1 3.0|
Acinus, Atrophy, Focal | 1 1 1 2 2 3 1 2 1 1 1 1 2 1 2 1 | 28 1.5|
Acinus, Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Diffuse | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
Parotid Gland, Atrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 2 2.0|
Epithelium, Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
12000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Focal | 1 | 2 1.5|
Glands, Cyst, Focal | 1 | 9 1.0|
__________________________________________________________________________|____________|
Tongue | | 3 |
Capillary, Erosion, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 3 1 2 1 1 2 2 1 2 1 2 1 1 1| 32 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 2 1 | 5 1.6|
Hypertrophy, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 1 1 1 1 1 | 17 1.3|
Bilateral, Hematopoietic Cell | | |
Proliferation | 1 | 1 1.0|
Bilateral, Hyperplasia, Focal | | 1 2.0|
Bilateral, Necrosis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 2 1 1 2 2 2 3 2 1 | 14 1.7|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Bilateral, Hyperplasia, Focal | 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Metaplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + M + + + + + + + +| 46 |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis, Focal | | 1 3.0|
Pars Distalis, Cyst | 2 2 2 2 1 2 1 2 2 | 17 1.8|
Pars Distalis, Hyperplasia, Focal | 2 2 | 2 2.0|
Rathke's Cleft, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia, Focal | 4 1 1 3 4 1 1 1 1 2| 18 1.8|
Follicle, Cyst | | 1 2.0|
Follicle, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
12000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Hyperplasia, Focal | 4 | 4 2.8|
Inflammation, Chronic | 1 2 | 4 1.8|
Inflammation, Chronic Active | 1 1 2 | 3 1.3|
Bilateral, Atrophy | 2 | 2 2.0|
Duct, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Pigmentation | 2 | 1 2.0|
Bursa, Cyst | 4 | 4 3.5|
Follicle, Cyst | | 2 2.0|
Periovarian Tissue, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 4 2.3|
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
Endometrium, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
Hyperplasia | 2 2 1 | 9 1.7|
Myelofibrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 2 2 1 1 1| 11 1.4|
Hyperplasia, Lymphoid | 1 4 | 4 2.0|
Infiltration Cellular, Histiocyte | 1 1 | 3 1.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 | 1 2.0|
Hemorrhage | 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 1 1 2 1 1 2 2| 33 1.3|
Pigmentation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
12000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 7 1.6|
Pigmentation | 1 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cyst | | 1 1.0|
Epithelial Cell, Hyperplasia | 1 2 2 1 1 1 2 2 2 1 1 2 2 2 2| 34 1.6|
Thymocyte, Atrophy | 2 2 2 2 2 2 2 | 19 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 2 1 1 2 2 1 3 1 4 | 15 1.9|
Inflammation, Chronic | 2 | 2 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Femur, Hyperostosis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 2.0|
Cerebellum, Hemorrhage, Focal | 1 | 1 1.0|
Cerebrum, Hemorrhage, Focal | 1 | 1 1.0|
Pons, Hemorrhage, Focal | | 1 2.0|
Thalamus, Cerebrum, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 4 3| 5 2.2|
Interstitium, Inflammation, Chronic | 1 1 | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
12000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Chronic Active | 2 2 | 6 2.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 | 2 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 2 | 6 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 2| 2 3.0|
Fibrosis, Focal | | 1 3.0|
Mineralization, Focal | 1 1 | 3 1.0|
Nephropathy, Chronic | | 1 1.0|
Bilateral, Mineralization, Focal | 1 1 | 5 1.0|
Bilateral, Nephropathy, Chronic | 2 1 2 1 1 1 1 1 2 1 2 1 1 1 1 2 1 1 2 2 2 2| 44 1.4|
Bilateral, Renal Tubule, Pigmentation| 2 2 3 2 | 9 1.9|
Pelvis, Inflammation, Acute | 1 | 2 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 2| 4| 3| 0| 3| 3| 3| 3| 3| 3| 6| 3|
| 5| 1| 5| 6| 6| 5| 5| 6| 8| 5| 7| 5| 5| 9| 7| 5| 3| 5| 5| 5| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25000 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Necrosis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X X X|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 1 1 |
Mixed Cell Focus | X X X X X X X X X X X X X X X |
Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 1 3 1 1 1 1 1 2 2 2 1 1 2 1 2 2 1|
Acinus, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Atrophy, Focal | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer, Focal | 2 3 |
Epithelium, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
Inflammation, Chronic | |
Glands, Cyst, Focal | 1 1 1 1 1 1 1 1 |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
Gingiva, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 2| 4| 3| 0| 3| 3| 3| 3| 3| 3| 6| 3|
| 5| 1| 5| 6| 6| 5| 5| 6| 8| 5| 7| 5| 5| 9| 7| 5| 3| 5| 5| 5| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25000 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 1 1 1 1 1 1 2 2 2 1 2 2 2|
Myocardium, Inflammation, Acute, | |
Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 1 2 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | 1 2 2 2 2 2 1 1 2 1 |
Bilateral, Hyperplasia, Focal | |
Bilateral, Necrosis | |
Bilateral, Vacuolization Cytoplasmic,| |
Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 2 2 1 1 1 4|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M M M + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | 1 2 2 2 2 2 2 2 2 1 1 2 |
Pars Distalis, Hyperplasia, Focal | 1 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 4 2 1 1 1 2 1 3|
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cyst | |
Hyperplasia, Focal | |
Inflammation, Chronic | 2 1 2 1 1 2 1 |
Inflammation, Chronic Active | |
Bilateral, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Bursa, Cyst | 4 3 |
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 1 3 |
Endometrium, Cyst | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 2| 4| 3| 0| 3| 3| 3| 3| 3| 3| 6| 3|
| 5| 1| 5| 6| 6| 5| 5| 6| 8| 5| 7| 5| 5| 9| 7| 5| 3| 5| 5| 5| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25000 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Hyperplasia | 2 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + +|
Iliac, Hemorrhage | 3 |
Iliac, Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia, Lymphoid | 2 2 1 1 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 1 1 1 1 1 2 1 1 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 |
Pigmentation | 2 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 |
Thymocyte, Atrophy | 3 3 3 2 3 2 2 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + M + + +|
Galactocele | 4 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + M + + +|
Subcutaneous Tissue, Fibrosis, Focal | |
Subcutaneous Tissue, Inflammation, | |
Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 2 2|
Cerebrum, Hemorrhage, Focal | |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 2| 4| 3| 0| 3| 3| 3| 3| 3| 3| 6| 3|
| 5| 1| 5| 6| 6| 5| 5| 6| 8| 5| 7| 5| 5| 9| 7| 5| 3| 5| 5| 5| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25000 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 2 1 2 3 |
Interstitium, Inflammation, Chronic | 1 1 1 1 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2|
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Chronic | 1 |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Mineralization, Focal | 1 1 1 1 |
Bilateral, Mineralization, Focal | 1 1 1 1 |
Bilateral, Nephropathy, Chronic | 1 1 2 2 2 1 2 2 2 1 2 1 2 1 1 1 1 2 2 1|
Bilateral, Pelvis, Mineralization, | |
Focal | 3|
Bilateral, Renal Tubule, Pigmentation| 2 2 2 2 2|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8| |
| 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + A + + + + + A| 45 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 1 | 4 1.8|
Basophilic Focus | X X X X X X X X X X X X X X X X X X | 34 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | X X X X X | 12 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 6 |
Inflammation, Chronic | 1 1 | 4 1.0|
Mixed Cell Focus | X X X X X X X X X X X X X X X X | 31 |
Necrosis | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Acinus, Atrophy, Diffuse | 2 | 1 2.0|
Acinus, Atrophy, Focal | 1 1 2 1 1 1 1 1 1 2 1 2 2 | 30 1.4|
Acinus, Hyperplasia, Focal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Atrophy, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Ulcer, Focal | 4 | 3 3.0|
Epithelium, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Focal | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Glands, Cyst, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 21 1.0|
Serosa, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 2 |
Developmental Malformation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8| |
| 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Gingiva, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 1 1 1 1 2 1 2 1 2 1 1 1 2 1 2 1| 34 1.4|
Myocardium, Inflammation, Acute, | | |
Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 5 1.6|
Hypertrophy, Focal | 3 1 4 | 3 2.7|
Vacuolization Cytoplasmic, Focal | 1 2 1 2 1 2 2 1| 18 1.6|
Bilateral, Hyperplasia, Focal | 2 | 1 2.0|
Bilateral, Necrosis | 2 | 1 2.0|
Bilateral, Vacuolization Cytoplasmic,| | |
Focal | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 3 1 1 1 3 1 | 15 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | 3 | 1 3.0|
Pars Distalis, Cyst | 2 1 2 1 | 16 1.7|
Pars Distalis, Hyperplasia, Focal | 1 | 2 1.0|
Pars Distalis, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 1 2 3 2 4 1 1 1 | 17 1.8|
Follicle, Cyst | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 1 4.0|
Hyperplasia, Focal | 3 2 2 3 | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8| |
| 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 | 8 1.4|
Inflammation, Chronic Active | 2 | 1 2.0|
Bilateral, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Bursa, Cyst | 3 2 | 4 3.0|
Follicle, Cyst | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 3 2.0|
Endometrium, Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 3 1.0|
Hyperplasia | 2 2 | 4 2.0|
Myelofibrosis | 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + +| 9 |
Iliac, Hemorrhage | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 2 | 2 1.5|
Hyperplasia, Lymphoid | 2 2 | 6 1.7|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Degeneration, Cystic | 3 2 1 | 4 2.0|
Hemorrhage | 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 1 1 1 2 2 1 1 1 2 1 2 1 | 31 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 3 1 1 | 6 1.3|
Pigmentation | 1 1 1 1 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 | 1 1.0|
Hemorrhage | | 1 2.0|
Epithelial Cell, Hyperplasia | 2 2 1 2 2 1 2 2 2 1 1 2 1 2 2 1 | 31 1.7|
Thymocyte, Atrophy | 3 3 4 3 1 2 2 2 | 20 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Galactocele | 2 1 1 2 1 1 1 2 1 1 1 | 14 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8| |
| 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcutaneous Tissue, Fibrosis, Focal | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Hyperostosis | 3 | 3 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 2 1 | 5 1.6|
Cerebrum, Hemorrhage, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 | 1 1.0|
Hemorrhage | 1 2 2 1 | 8 1.8|
Interstitium, Inflammation, Chronic | 2 1 | 6 1.2|
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | 1 2 | 2 1.5|
Inflammation, Chronic Active | 2 2 | 3 2.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 1 1.0|
Lens, Cataract | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8| |
| 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Retina, Atrophy | | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Mineralization, Focal | 1 | 5 1.0|
Bilateral, Mineralization, Focal | 1 1 1 1 1 | 9 1.0|
Bilateral, Nephropathy, Chronic | 1 2 1 2 1 1 1 1 1 2 2 2 1 1 1 2 2 2 2 2 1 2 2 | 43 1.5|
Bilateral, Pelvis, Mineralization, | | |
Focal | | 1 3.0|
Bilateral, Renal Tubule, Pigmentation| 1 2| 7 1.9|
Pelvis, Dilatation | 2 | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 5| 1| 5| 5| 5| 6| 6| 5| 2| 5| 2| 5| 6| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + A + + +|
Ulcer, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Ulcer, Focal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 1 |
Mixed Cell Focus | X X X X X X X X X X X X X X X |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Accessory Spleen | |
Fat, Necrosis | 2 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + M + + + + + + + + + + + + M + + M|
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 2 2 1 2 2 1 1 1 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
Parotid Gland, Atrophy, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +|
Ulcer, Focal | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + + A + + +|
Erosion, Focal | 2 |
Glands, Cyst, Focal | 1 1 1 |
__________________________________________________________________________|
Tongue | + |
Capillary, Erosion, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 5| 1| 5| 5| 5| 6| 6| 5| 2| 5| 2| 5| 6| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | 2 4 2 |
Inflammation, Acute, Focal | |
Vacuolization Cytoplasmic, Focal | 1 1 2 1 2 |
Bilateral, Hyperplasia, Focal | 2 |
Bilateral, Vacuolization Cytoplasmic,| |
Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Focal | 2 1 1 1 1 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + M + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | 2 2 1 2 |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + A + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia, Focal | 1 1 2 1 1 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Focal | 4 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Atrophy | |
Bilateral, Cyst | 3 |
Bursa, Cyst | 2 |
Follicle, Cyst | 1 2 |
__________________________________________________________________________|
Oviduct | + |
Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 2 |
Thrombosis | 3 |
Endometrium, Cyst | 1 2 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 5| 1| 5| 5| 5| 6| 6| 5| 2| 5| 2| 5| 6| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 |
Hyperplasia | 2 2 2 |
Myelofibrosis | 2 1 |
__________________________________________________________________________|
Lymph Node | + + +|
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + A + + +|
Degeneration, Cystic | 1 1 1 1 1 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 2 1 |
Infiltration Cellular, Histiocyte | |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + A + + +|
Degeneration, Cystic | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 2 1 1 2 1 1 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + M + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 1 2 |
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | |
Epithelial Cell, Hyperplasia | 1 2 2 1 2 2 2 2 2 2 2 1 |
Thymocyte, Atrophy | 2 2 3 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 2 1 2 1 1 2 1 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hemorrhage, Focal | |
Meninges, Cerebrum, Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 5| 1| 5| 5| 5| 6| 6| 5| 2| 5| 2| 5| 6| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Focal, | |
Histiocyte | |
Interstitium, Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 |
Inflammation, Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
Cyst | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Ectopic Liver | |
Mineralization, Focal | |
Nephropathy, Chronic | |
Bilateral, Mineralization, Focal | 1 1 |
Bilateral, Nephropathy, Chronic | 1 1 3 2 2 1 2 1 2 2 2 3 1 1 3 2 1 1 2 1 2 1|
Bilateral, Renal Tubule, | |
Accumulation, Hyaline Droplet | 3 2 |
Bilateral, Renal Tubule, Pigmentation| 1 3 1 1 1 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3| |
| 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
50000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ulcer, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X X X X| 34 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X | 4 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X | 4 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | 1 1 1 | 4 1.0|
Mixed Cell Focus | X X X X X X X X X X X X X X X X X X| 33 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Accessory Spleen | X | 1 |
Fat, Necrosis | 2 | 5 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 46 |
Acinus, Atrophy, Diffuse | 4 | 2 4.0|
Acinus, Atrophy, Focal | 2 2 1 1 2 1 1 1 3 2 2 1 1 2| 22 1.5|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parotid Gland, Atrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer, Focal | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Erosion, Focal | 2 | 2 2.0|
Glands, Cyst, Focal | 1 | 4 1.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
Capillary, Erosion, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3| |
| 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
50000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 1 2 2 2 1 2 3 1 1 2 1 1 1 3 1 1| 27 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia, Focal | 2 1 1 2| 6 1.5|
Hypertrophy, Focal | | 3 2.7|
Inflammation, Acute, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 2 2 | 10 1.6|
Bilateral, Hyperplasia, Focal | | 1 2.0|
Bilateral, Vacuolization Cytoplasmic,| | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 1 3 3 2 | 11 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + + + + + M + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Angiectasis, Focal | 2 3 3 3 2| 5 2.6|
Pars Distalis, Cyst | 1 2 2 3 1 1 2 | 11 1.7|
Pars Distalis, Hyperplasia, Focal | 3 2 4 | 4 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ultimobranchial Cyst | 2 | 2 1.5|
C-Cell, Hyperplasia, Focal | 1 1 3 1 | 9 1.3|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | 3 2 | 3 3.0|
Inflammation, Chronic | 2 1 1 1| 7 1.1|
Inflammation, Chronic Active | 3 | 5 1.6|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Atrophy | 2 | 1 2.0|
Bilateral, Cyst | | 1 3.0|
Bursa, Cyst | 2 2 3 2 3| 6 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3| |
| 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
50000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Follicle, Cyst | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Oviduct | | 1 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 1 1 | 6 1.7|
Thrombosis | | 1 3.0|
Endometrium, Cyst | 2 | 4 1.8|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 | 5 1.2|
Hyperplasia | 2 1 2 | 6 1.8|
Myelofibrosis | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 9 |
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration, Cystic | 1 1 1 | 8 1.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | 2 2 | 5 1.8|
Infiltration Cellular, Histiocyte | 1 1 1| 3 1.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Degeneration, Cystic | 1 | 1 1.0|
Hemorrhage | 2 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 2 2 1 1 1 1 1| 26 1.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 1 1 3 2| 6 1.7|
Pigmentation | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 1 | 1 1.0|
Epithelial Cell, Hyperplasia | 1 1 2 1 2 2 1 3 2 1 1| 23 1.7|
Thymocyte, Atrophy | 2 2 2 3 2 2 2 2 2 1 3 1 1 2| 23 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3| |
| 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
50000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | 2 1 1 1 2 1 1 1 3| 17 1.5|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Hemorrhage, Focal | 2 | 1 2.0|
Meninges, Cerebrum, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 2| 4 1.5|
Infiltration Cellular, Focal, | | |
Histiocyte | 1| 1 1.0|
Interstitium, Inflammation, Chronic | 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 4 1.3|
Inflammation, Chronic Active | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3| |
| 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
50000 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Ectopic Liver | X | 1 |
Mineralization, Focal | 1 1 1 | 3 1.0|
Nephropathy, Chronic | 1 1 | 2 1.0|
Bilateral, Mineralization, Focal | 1 1 1 | 5 1.0|
Bilateral, Nephropathy, Chronic | 2 2 2 1 2 1 1 2 1 2 1 1 1 1 2 1 1 2 1 2| 42 1.6|
Bilateral, Renal Tubule, | | |
Accumulation, Hyaline Droplet | | 2 2.5|
Bilateral, Renal Tubule, Pigmentation| 1 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|
| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 3 3 2 2|
Basophilic Focus | X X X X X X 1 X X X |
Clear Cell Focus | X X |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 1 1 2 1 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| |
Vein, Thrombosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Fat, Necrosis | 3 3 3 3 4 4 2 3 2|
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | 2 2 2 2 2 2 1 2 3 2 2|
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Duct, Sublingual Gland, Hyperplasia, | |
Focal | 2 |
Sublingual Gland, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer, Focal | 2 |
Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|
| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion, Focal | 2 2 2 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 1 2 1 3 1 4 2 2 2 1 2 2 2 1 2 1 2 2 1|
Atrium, Thrombosis | 3 |
Atrium, Epicardium, Hyperplasia, | |
Focal | 2 |
Atrium, Epicardium, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 2 1|
Hypertrophy, Focal | 1 2 |
Vacuolization Cytoplasmic, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 3 3 2 2 4 3 |
Infiltration Cellular, Lymphocyte | |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + M + + + + + M + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 3 3 1 |
Pars Distalis, Hypertrophy, Focal | 1 |
Pars Nervosa, Hyperplasia | 2 |
Rathke's Cleft, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 1 4 1 2 1 1 2|
Follicle, Cyst | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 4 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|
| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 1 1 1 |
Inflammation, Chronic Active | |
Bilateral, Inflammation, Chronic | 2 3 1 1 2 2 2 2 2 2 1 1 2 1|
Bilateral, Inflammation, Chronic | |
Active | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 4 1 2 2 2 1 2 |
Inflammation, Acute | 1 1|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 3 |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 2 2 3 3 2 3 3 1 4 3 2 3 3 2 3 2 3|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Bilateral, Interstitial Cell, | |
Hyperplasia, Focal | 1 |
Bilateral, Germinal Epithelium, | |
Atrophy | 4 4 4 4 |
Germinal Epithelium, Atrophy | |
Interstitial Cell, Hyperplasia, Focal| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 1 2 2 2 2 1 2 2 2|
Myelofibrosis | 2 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Mediastinal, Hemorrhage | 4|
Mediastinal, Pigmentation | 1 |
Pancreatic, Hemorrhage | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 3 3 3 2 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 2 2 |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 2 1 3 1 2 2 1 2 2 2 2 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|
| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 2 2 |
Capsule, Degeneration, Cystic | 2 |
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Epithelial Cell, Hyperplasia | 1 2 2 2 2 2 2 1 2 2 2 2 2 1 3 1 1|
Thymocyte, Atrophy | 2 4 2 3 3 3 4 4 2 4 4 4 2 2 1 3 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + M + + +|
Galactocele | 2 1 |
Pigmentation | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
Hippocampus, Cerebrum, Necrosis, | |
Focal | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Hemorrhage | 3 |
Infiltration Cellular, Focal, | |
Histiocyte | |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|
| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 3 3 3 3 3 3 2 3|
Metaplasia, Squamous | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst, Focal | 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Mineralization, Focal | 1 |
Nephropathy, Chronic | 2 2 |
Bilateral, Nephropathy, Chronic | 2 2 3 1 2 2 3 2 1 2 2 2 2 2 1 2 2 2 2 1 2 1 2|
Bilateral, Pelvis, Transitional | |
Epithelium, Hyperplasia | |
Bilateral, Renal Tubule, Pigmentation| 3 3 3 2 1 3|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| 4| 4| 7| 5| 6| 5| 7| 5| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 2| 4| 2| 1| 8| 9| 2| 5| 7| 9| 2| 0| 4| 1| 8| 2| 9| 7| 0| 2| 0| 2| 0| 0| |
| 9| 9| 9| 9| 5| 6| 8| 9| 3| 1| 8| 9| 6| 3| 5| 5| 9| 0| 1| 8| 9| 4| 7| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + A + + + + +| 48 |
Parasite Metazoan | X| 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + A + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + A + A + + A A + + A + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + A + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + A A + + + + + + + + +| 47 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + A + + A A + + A + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 1 | 7 2.1|
Basophilic Focus | X X X X X X X | 17 1.0|
Clear Cell Focus | | 2 |
Degeneration, Cystic, Focal | 2 2 2 2 | 4 2.0|
Eosinophilic Focus | X X X | 8 |
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Hepatodiaphragmatic Nodule | X | 4 |
Mixed Cell Focus | X X X | 4 |
Necrosis | 4 | 1 4.0|
Bile Duct, Hyperplasia | 2 1 1 3 | 10 1.6|
Centrilobular, Necrosis | 4 3 | 2 3.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 | 3 2.0|
Vein, Thrombosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + M +| 20 |
Fat, Necrosis | 3 3 3 2 3 3 3 2 3 2| 19 2.8|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
Acinus, Atrophy, Diffuse | | 1 3.0|
Acinus, Atrophy, Focal | 2 1 1 2 4 2 1 3 2 1 2 | 22 2.0|
Acinus, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Duct, Sublingual Gland, Hyperplasia, | | |
Focal | | 1 2.0|
Sublingual Gland, Inflammation, | | |
Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| 4| 4| 7| 5| 6| 5| 7| 5| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 2| 4| 2| 1| 8| 9| 2| 5| 7| 9| 2| 0| 4| 1| 8| 2| 9| 7| 0| 2| 0| 2| 0| 0| |
| 9| 9| 9| 9| 5| 6| 8| 9| 3| 1| 8| 9| 6| 3| 5| 5| 9| 0| 1| 8| 9| 4| 7| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Ulcer, Focal | 2 | 2 2.0|
Epithelium, Hyperplasia | 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Focal | 2 2 3 3 2 | 8 2.3|
Inflammation, Acute | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 1 1 3 3 2 2 2 2 1 2 2 2 2 2 3 2| 39 1.9|
Atrium, Thrombosis | 4 4 | 3 3.7|
Atrium, Epicardium, Hyperplasia, | | |
Focal | | 1 2.0|
Atrium, Epicardium, Pigmentation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 4 1.5|
Hypertrophy, Focal | | 2 1.5|
Vacuolization Cytoplasmic, Focal | 2 2 3 1 | 6 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 2 2 1 2 | 12 2.3|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Bilateral, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + M + + + + M + + M + M + + + +| 41 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | | 1 2.0|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 3 1 1 | 9 1.9|
Pars Distalis, Hypertrophy, Focal | | 1 1.0|
Pars Nervosa, Hyperplasia | | 1 2.0|
Rathke's Cleft, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 3 1 1 1 | 13 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| 4| 4| 7| 5| 6| 5| 7| 5| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 2| 4| 2| 1| 8| 9| 2| 5| 7| 9| 2| 0| 4| 1| 8| 2| 9| 7| 0| 2| 0| 2| 0| 0| |
| 9| 9| 9| 9| 5| 6| 8| 9| 3| 1| 8| 9| 6| 3| 5| 5| 9| 0| 1| 8| 9| 4| 7| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Mediastinum, Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 3 3.3|
Inflammation, Chronic | 1 1 2 1 2 1 2 2 1 | 14 1.4|
Inflammation, Chronic Active | 1 | 1 1.0|
Bilateral, Inflammation, Chronic | 2 1 1 2 3 2 1| 21 1.7|
Bilateral, Inflammation, Chronic | | |
Active | 3 3 3 2 | 6 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 | 14 1.9|
Inflammation, Acute | 3 2 3 2 | 6 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 3 | 3 2.7|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 2 3 2 2 2 3 3 2 3 2 3 | 33 2.5|
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Focal | | 1 2.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia, Focal | 4| 2 2.5|
Bilateral, Germinal Epithelium, | | |
Atrophy | | 4 4.0|
Germinal Epithelium, Atrophy | 4 4 | 2 4.0|
Interstitial Cell, Hyperplasia, Focal| 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + A + + + + + + + + + + +| 48 |
Atrophy | | 1 2.0|
Hyperplasia | 2 2 2 2 2 1 | 15 1.8|
Myelofibrosis | | 1 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05182-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENOLPHTHALEIN Date: 10/23/95
Route: DOSED FEED Time: 16:52:04
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| 4| 4| 7| 5| 6| 5| 7| 5| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 2| 4| 2| 1| 8| 9| 2| 5| 7| 9| 2| 0| 4| 1| 8| 2| 9| 7| 0| 2| 0| 2| 0| 0| |
| 9| 9| 9| 9| 5| 6| 8| 9| 3| 1| 8| 9| 6| 3| 5| 5| 9| 0| 1| 8| 9| 4| 7| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 17 |
Mediastinal, Hemorrhage | | 1 4.0|
Mediastinal, Pigmentation | | 1 1.0|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Renal, Hemorrhage | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 1 | 9 2.1|
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 2 2 | 7 1.9|
Infiltration Cellular, Histiocyte | 2 | 2 1.5|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 3 | 4 2.3|
Hyperplasia, Lymphoid | 2| 1 2.0|
Infiltration Cellular, Histiocyte | 2 1 2 2 1 2 2 2 1 2 2 2 1 1 | 33 1.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Fibrosis | 2 2 2 | 3 2.0|
Hematopoietic Cell Proliferation | 1 3 1 | 6 1.7|
Capsule, Degeneration, Cystic | | 1 2.0|
Lymphoid Follicle, Atrophy | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 2| 3 2.3|
Epithelial Cell, Hyperplasia | 2 2 1 2 1 1 2 | 24 1.7|
Thymocyte, Atrophy | 2 3 3 4 4 3 2 2 2 3 4 3 3 1