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TDMS Study 05184-05 Pathology Tables

NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52

                                                         2 YEAR CHRONIC




       Facility:  Battelle Northwest

       Chemical CAS #:  111-30-8

       Lock Date:  07/28/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           17           32           34                                     
    Natural Death                                      2            2            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           31           15           14                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (49)         (49)                                   
      Diverticulum                                                                            1 (2%)                                
      Parasite Metazoan                                2 (4%)       4 (8%)       1 (2%)       1 (2%)                                
   Intestine Large, Rectum                            (48)         (50)         (49)         (49)                                   
      Parasite Metazoan                                3 (6%)       4 (8%)       4 (8%)                                             
   Intestine Large, Cecum                             (48)         (48)         (49)         (49)                                   
      Parasite Metazoan                                5 (10%)      4 (8%)       3 (6%)       3 (6%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                    2 (4%)                                             
      Basophilic Focus                                 1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Basophilic Focus, Multiple                       1 (2%)                    2 (4%)       2 (4%)                                
      Clear Cell Focus                                 6 (12%)      4 (8%)       4 (8%)       3 (6%)                                
      Clear Cell Focus, Multiple                                    3 (6%)       2 (4%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hepatodiaphragmatic Nodule                       3 (6%)       6 (12%)      3 (6%)       3 (6%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Necrosis                                         2 (4%)                                                                       
      Vacuolization Cytoplasmic                        5 (10%)      1 (2%)                    3 (6%)                                
   Mesentery                                          (10)         (9)          (7)          (3)                                    
      Inflammation, Granulomatous                                                1 (14%)                                            
      Fat, Necrosis                                    9 (90%)      9 (100%)     7 (100%)     3 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  3 (6%)       3 (6%)       3 (6%)       4 (8%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Erosion                                                                                 1 (2%)                                
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Suppurative                        3 (6%)       4 (8%)       2 (4%)       4 (8%)                                
      Ulcer                                            3 (6%)       2 (4%)       2 (4%)       2 (4%)                                
      Epithelium, Hyperplasia                          3 (6%)       4 (8%)       3 (6%)       5 (10%)                               
   Stomach, Glandular                                 (49)         (49)         (50)         (50)                                   
      Erosion                                                       1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       2 (4%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tongue                                             (1)          (1)                                                              
      Hyperkeratosis                                                1 (100%)                                                        
      Hyperplasia                                                   1 (100%)                                                        
   Tooth                                              (1)          (2)                       (3)                                    
      Degeneration                                     1 (100%)     2 (100%)                  2 (67%)                               
      Inflammation, Suppurative                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (49)                                   
      Inflammation                                     1 (2%)       1 (2%)                    1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
   Heart                                              (50)         (50)         (50)         (50)                                   
      Atrium, Thrombosis                               1 (2%)       1 (2%)                                                          
      Myocardium, Fibrosis                             3 (6%)       1 (2%)       4 (8%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Atrophy                                                       1 (2%)                                                          
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Vacuolization Cytoplasmic                        7 (14%)      6 (12%)     11 (22%)      9 (18%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                      2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (42)         (39)         (44)         (36)                                   
      Hyperplasia                                                                2 (5%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (49)                                   
      Cyst                                             3 (6%)       1 (2%)       3 (6%)       2 (4%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia                       3 (6%)       4 (8%)       4 (8%)       7 (14%)                               
   Thyroid Gland                                      (50)         (50)         (49)         (49)                                   
      C-Cell, Hyperplasia                              3 (6%)       4 (8%)       4 (8%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      4 (8%)       7 (14%)                   2 (4%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                    1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (49)                                   
      Cyst                                             2 (4%)       3 (6%)       7 (14%)      3 (6%)                                
      Cyst, Multiple                                                                          1 (2%)                                
      Bilateral, Cyst                                  1 (2%)                                                                       
   Oviduct                                                                      (1)                                                 
      Cyst                                                                       1 (100%)                                           
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hydrometra                                                                 1 (2%)                                             
      Cervix, Myometrium, Hypertrophy                               1 (2%)                                                          
   Vagina                                             (1)                                                                           
      Inflammation                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                   2 (4%)                                             
   Lymph Node, Bronchial                              (46)         (46)         (48)         (42)                                   
      Fibrosis                                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                                1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                                           1 (2%)       1 (2%)                                
      Fibrosis                                         5 (10%)      7 (14%)      8 (16%)      4 (8%)                                
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)       1 (2%)                                             
      Hemorrhage                                       1 (2%)                    2 (4%)       1 (2%)                                
   Thymus                                             (50)         (50)         (50)         (49)                                   
      Cyst                                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                      2 (4%)       2 (4%)                                                          
      Hyperplasia                                                                             1 (2%)                                
      Metaplasia, Squamous                             1 (2%)                                                                       
      Epithelium, Hyperplasia                                                    2 (4%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)       3 (6%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Hyperkeratosis                                   2 (4%)                                                                       
      Inflammation, Suppurative                                                               1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
      Hair Follicle, Inflammation, Chronic                                       1 (2%)                                             
      Subcutaneous Tissue, Inflammation                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteopetrosis                                                              1 (2%)                                             
      Sternum, Cyst                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Hemorrhage                                       3 (6%)       1 (2%)       7 (14%)      3 (6%)                                
      Hydrocephalus                                   10 (20%)     10 (20%)      7 (14%)      2 (4%)                                
   Spinal Cord                                        (1)          (2)                       (4)                                    
      Demyelination                                                 2 (100%)                  2 (50%)                               
      Neuron, Degeneration                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (50)         (50)         (49)                                   
      Foreign Body                                     4 (8%)       3 (6%)       2 (4%)       6 (12%)                               
      Epiglottis, Inflammation, Suppurative            1 (2%)                    2 (4%)       5 (10%)                               
      Epiglottis, Metaplasia, Squamous                                                        1 (2%)                                
      Glands, Inflammation                            20 (41%)     16 (32%)     18 (36%)     19 (39%)                               
      Squamous Epithelium, Hyperplasia                 5 (10%)      1 (2%)       1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (49)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 7 (14%)      4 (8%)       2 (4%)       4 (8%)                                
      Alveolus, Emphysema                                                                     2 (4%)                                
      Alveolus, Hemorrhage                             1 (2%)                    1 (2%)                                             
      Alveolus, Infiltration Cellular, Histiocyte     29 (58%)     24 (48%)     22 (44%)     35 (71%)                               
      Alveolus, Inflammation, Suppurative              2 (4%)       1 (2%)                    1 (2%)                                
      Interstitium, Fibrosis                           9 (18%)     13 (26%)     17 (34%)     24 (49%)                               
      Venule, Thrombosis                                            1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (49)                                   
      Concretion                                       2 (4%)                                                                       
      Foreign Body                                     5 (10%)      3 (6%)       2 (4%)                                             
      Goblet Cell, Respiratory Epithelium,                                                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
          Hyperplasia                                  1 (2%)       3 (6%)       5 (10%)      8 (16%)                               
      Nasolacrimal Duct, Inflammation                  4 (8%)       2 (4%)       2 (4%)       1 (2%)                                
      Olfactory Epithelium, Atrophy                                                           2 (4%)                                
      Olfactory Epithelium, Degeneration, Hyaline      4 (8%)       5 (10%)     12 (24%)     15 (31%)                               
      Olfactory Epithelium, Inflammation                                         1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              1 (2%)       6 (12%)     15 (30%)     29 (59%)                               
      Respiratory Epithelium, Inflammation             5 (10%)      9 (18%)     26 (52%)     42 (86%)                               
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       1 (2%)      11 (22%)     16 (33%)                               
      Septum, Respiratory Epithelium, Ulcer                                      1 (2%)                                             
      Squamous Epithelium, Hyperplasia                 3 (6%)      15 (30%)     29 (58%)     45 (92%)                               
      Squamous Epithelium, Inflammation                6 (12%)     26 (52%)     42 (84%)     48 (98%)                               
   Pleura                                                          (2)                                                              
      Hyperplasia, Focal                                            1 (50%)                                                         
      Inflammation, Chronic                                         1 (50%)                                                         
   Trachea                                            (49)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)          (3)                                                 
      Atrophy                                                       1 (50%)                                                         
      Cataract                                         1 (50%)      1 (50%)      3 (100%)                                           
      Degeneration                                     1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Nephropathy, Chronic                            38 (78%)     42 (84%)     37 (74%)     33 (66%)                               
      Pelvis, Dilatation                               1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                33           30           32           37                                     
    Natural Death                                      5            6            9            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                11           14            9            6                                     
    Natural Death                                      1                                                                            

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (48)         (48)         (45)                                   
      Mineralization                                                             1 (2%)                                             
      Parasite Metazoan                                2 (4%)       3 (6%)                                                          
      Muscularis, Mineralization                       1 (2%)                                                                       
   Intestine Large, Rectum                            (50)         (48)         (49)         (46)                                   
      Diverticulum                                                                            1 (2%)                                
      Parasite Metazoan                                             4 (8%)       2 (4%)       3 (7%)                                
   Intestine Large, Cecum                             (47)         (46)         (48)         (45)                                   
      Parasite Metazoan                                3 (6%)       1 (2%)       9 (19%)      2 (4%)                                
   Intestine Small, Jejunum                           (47)         (46)         (43)         (44)                                   
      Necrosis                                                                                1 (2%)                                
   Intestine Small, Ileum                             (46)         (46)         (44)         (44)                                   
      Inflammation, Focal, Suppurative                 1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
      Basophilic Focus                                 1 (2%)       1 (2%)                                                          
      Clear Cell Focus                                              4 (8%)       1 (2%)       1 (2%)                                
      Clear Cell Focus, Multiple                                                 2 (4%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)       2 (4%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                         1 (2%)       2 (4%)       1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic                        7 (14%)      1 (2%)       2 (4%)       1 (2%)                                
      Bile Duct, Hyperplasia                           3 (6%)                                 2 (4%)                                
      Hepatocyte, Degeneration, Focal                  3 (6%)                                 1 (2%)                                
      Hepatocyte, Hyperplasia                          1 (2%)                                                                       
   Mesentery                                          (10)         (7)          (6)          (7)                                    
      Hemorrhage                                                                 1 (17%)                                            
      Thrombosis                                                                 1 (17%)                                            
      Fat, Necrosis                                    8 (80%)      6 (86%)      5 (83%)      6 (86%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (49)         (50)         (48)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Acinus, Atrophy                                  9 (18%)      3 (6%)       2 (4%)       5 (10%)                               
   Stomach, Forestomach                               (49)         (49)         (50)         (48)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Suppurative                        8 (16%)      3 (6%)       3 (6%)       5 (10%)                               
      Mineralization                                   4 (8%)       1 (2%)       1 (2%)                                             
      Ulcer                                            5 (10%)      7 (14%)      4 (8%)       2 (4%)                                
      Epithelium, Hyperplasia                         11 (22%)      2 (4%)       2 (4%)       4 (8%)                                
   Stomach, Glandular                                 (49)         (49)         (50)         (48)                                   
      Erosion                                          1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Ulcer                                                         2 (4%)                                                          
      Epithelium, Mineralization                       9 (18%)      5 (10%)      3 (6%)       4 (8%)                                
      Epithelium, Necrosis                                                       1 (2%)                                             
   Tongue                                             (1)          (2)                       (1)                                    
      Hyperkeratosis                                                1 (50%)                                                         
   Tooth                                              (1)                                    (8)                                    
      Degeneration                                     1 (100%)                               8 (100%)                              
      Inflammation                                                                            1 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (45)         (50)         (50)         (50)                                   
      Inflammation                                     1 (2%)       2 (4%)                                                          
      Mineralization                                   7 (16%)      3 (6%)       1 (2%)       4 (8%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Mineralization                                   6 (12%)      2 (4%)       1 (2%)       4 (8%)                                
      Atrium, Thrombosis                               3 (6%)       2 (4%)       1 (2%)                                             
      Myocardium, Fibrosis                            12 (24%)     10 (20%)      8 (16%)      7 (14%)                               
      Myocardium, Ventricle, Hypertrophy                                         1 (2%)                                             
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Vacuolization Cytoplasmic                        9 (18%)      6 (12%)      8 (16%)      2 (4%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                     12 (24%)      9 (18%)      6 (12%)      2 (4%)                                
      Bilateral, Hyperplasia                           1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (49)         (50)         (48)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (42)         (38)         (45)         (41)                                   
      Hyperplasia                                      7 (17%)      7 (18%)      1 (2%)       3 (7%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Cyst                                             2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)                    3 (6%)       3 (6%)                                
      Pars Distalis, Hyperplasia                       6 (12%)      5 (10%)      4 (8%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                              6 (12%)      2 (4%)       8 (16%)      5 (10%)                               
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 (2%)                                                          
      Spermatocele                                     1 (2%)                                                                       
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                                                       1 (2%)                                             
      Hyperplasia                                                   1 (2%)       2 (4%)                                             
      Inflammation, Suppurative                        5 (10%)      2 (4%)       3 (6%)       1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 (2%)       2 (4%)                                             
      Inflammation                                     9 (18%)      4 (8%)       5 (10%)      3 (6%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Suppurative                        3 (6%)       1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Arteriole, Inflammation                          1 (2%)                                                                       
      Bilateral, Interstitial Cell, Hyperplasia        4 (8%)                    1 (2%)       4 (8%)                                
      Germinal Epithelium, Atrophy                    12 (24%)      9 (18%)     13 (26%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrosis                                         7 (14%)      5 (10%)      2 (4%)       3 (6%)                                
   Lymph Node, Bronchial                              (39)         (42)         (40)         (42)                                   
      Fibrosis                                         1 (3%)       1 (2%)                                                          
   Lymph Node, Mandibular                             (47)         (48)         (49)         (49)                                   
      Hyperplasia                                                                1 (2%)                                             
   Lymph Node, Mediastinal                            (47)         (50)         (50)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                                                        1 (2%)                                
      Fibrosis                                        15 (30%)     15 (30%)     16 (32%)      9 (18%)                               
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Infarct                                                       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)         (50)                                   
      Galactocele                                      2 (4%)       1 (2%)       5 (10%)                                            
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        2 (4%)       2 (4%)                                                          
      Hyperkeratosis                                                                          1 (2%)                                
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
      Ulcer                                                         1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Tibia, Fracture                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       3 (6%)       4 (8%)      10 (20%)      1 (2%)                                
      Hydrocephalus                                    5 (10%)      7 (14%)     10 (20%)      5 (10%)                               
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
      Epiglottis, Inflammation, Suppurative            1 (2%)                                 1 (2%)                                
      Glands, Inflammation                            28 (56%)     18 (36%)     18 (36%)     26 (52%)                               
      Squamous Epithelium, Hyperplasia                 1 (2%)                    1 (2%)       1 (2%)                                
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation                                                                            1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 9 (18%)      3 (6%)       5 (10%)      4 (8%)                                
      Alveolus, Emphysema                              1 (2%)                                                                       
      Alveolus, Hemorrhage                             3 (6%)       2 (4%)       1 (2%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolus, Infiltration Cellular, Histiocyte     23 (46%)     15 (30%)     14 (28%)     11 (22%)                               
      Alveolus, Inflammation, Suppurative                           2 (4%)                    2 (4%)                                
      Alveolus, Metaplasia, Osseous                                 1 (2%)       1 (2%)                                             
      Alveolus, Mineralization                         4 (8%)       3 (6%)       1 (2%)       4 (8%)                                
      Bronchiole, Foreign Body                                                                1 (2%)                                
      Bronchiole, Hyperplasia                                                    1 (2%)                                             
      Bronchiole, Inflammation, Suppurative                                      1 (2%)                                             
      Interstitium, Fibrosis                           8 (16%)     14 (28%)     17 (34%)      7 (14%)                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     2 (4%)       2 (4%)       1 (2%)                                             
      Goblet Cell, Respiratory Epithelium,                                                                                          
          Hyperplasia                                  1 (2%)                    6 (12%)      6 (12%)                               
      Nasolacrimal Duct, Inflammation                               3 (6%)                                                          
      Olfactory Epithelium, Atrophy                                                           4 (8%)                                
      Olfactory Epithelium, Degeneration, Hyaline      4 (8%)       8 (16%)      9 (18%)     14 (28%)                               
      Olfactory Epithelium, Foreign Body               1 (2%)                    1 (2%)                                             
      Olfactory Epithelium, Hyperplasia                             1 (2%)                                                          
      Olfactory Epithelium, Inflammation               1 (2%)       1 (2%)       1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              6 (12%)      5 (10%)     17 (34%)     35 (70%)                               
      Respiratory Epithelium, Inflammation            17 (34%)     10 (20%)     25 (50%)     43 (86%)                               
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       2 (4%)      11 (22%)     24 (48%)                               
      Squamous Epithelium, Foreign Body                1 (2%)                                                                       
      Squamous Epithelium, Hyperplasia                 3 (6%)      11 (22%)     39 (78%)     48 (96%)                               
      Squamous Epithelium, Inflammation                6 (12%)     17 (34%)     41 (82%)     49 (98%)                               
   Pleura                                             (2)                                                                           
      Inflammation, Suppurative                        1 (50%)                                                                      
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Mineralization                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (3)                                                 
      Cataract                                         1 (100%)     3 (100%)     2 (67%)                                            
      Inflammation, Suppurative                                                  1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                          2 (4%)       1 (2%)       2 (4%)                                
      Infarct                                                       1 (2%)                                                          
      Mineralization                                   3 (6%)       1 (2%)                                                          
      Nephropathy, Chronic                            43 (86%)     48 (96%)     48 (96%)     38 (76%)                               
      Papilla, Transitional Epithelium, Hyperplasia    1 (2%)       1 (2%)                                                          
      Pelvis, Dilatation                               1 (2%)                                                                       
      Pelvis, Inflammation, Suppurative                1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:20:52  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Atrophy                            1 (2%)                                                                       
      Renal Tubule, Atypia Cellular                    1 (2%)                                                                       
      Renal Tubule, Regeneration                       1 (2%)                                                                       
   Urinary Bladder                                    (50)         (49)         (50)         (48)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             2 (4%)                    1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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