TDMS Study 05184-05 Pathology Tables
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
2 YEAR CHRONIC
Facility: Battelle Northwest
Chemical CAS #: 111-30-8
Lock Date: 07/28/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 22 17 32 34
Natural Death 2 2 3 2
Survivors
Terminal Sacrifice 26 31 15 14
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (49) (49)
Diverticulum 1 (2%)
Parasite Metazoan 2 (4%) 4 (8%) 1 (2%) 1 (2%)
Intestine Large, Rectum (48) (50) (49) (49)
Parasite Metazoan 3 (6%) 4 (8%) 4 (8%)
Intestine Large, Cecum (48) (48) (49) (49)
Parasite Metazoan 5 (10%) 4 (8%) 3 (6%) 3 (6%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 2 (4%)
Basophilic Focus 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Basophilic Focus, Multiple 1 (2%) 2 (4%) 2 (4%)
Clear Cell Focus 6 (12%) 4 (8%) 4 (8%) 3 (6%)
Clear Cell Focus, Multiple 3 (6%) 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 6 (12%) 3 (6%) 3 (6%)
Inflammation, Granulomatous 1 (2%)
Necrosis 2 (4%)
Vacuolization Cytoplasmic 5 (10%) 1 (2%) 3 (6%)
Mesentery (10) (9) (7) (3)
Inflammation, Granulomatous 1 (14%)
Fat, Necrosis 9 (90%) 9 (100%) 7 (100%) 3 (100%)
Pancreas (50) (50) (50) (50)
Acinus, Atrophy 3 (6%) 3 (6%) 3 (6%) 4 (8%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Erosion 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Suppurative 3 (6%) 4 (8%) 2 (4%) 4 (8%)
Ulcer 3 (6%) 2 (4%) 2 (4%) 2 (4%)
Epithelium, Hyperplasia 3 (6%) 4 (8%) 3 (6%) 5 (10%)
Stomach, Glandular (49) (49) (50) (50)
Erosion 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tongue (1) (1)
Hyperkeratosis 1 (100%)
Hyperplasia 1 (100%)
Tooth (1) (2) (3)
Degeneration 1 (100%) 2 (100%) 2 (67%)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (49)
Inflammation 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Heart (50) (50) (50) (50)
Atrium, Thrombosis 1 (2%) 1 (2%)
Myocardium, Fibrosis 3 (6%) 1 (2%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Atrophy 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 7 (14%) 6 (12%) 11 (22%) 9 (18%)
Adrenal Medulla (50) (50) (50) (49)
Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Islets, Pancreatic (49) (50) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (42) (39) (44) (36)
Hyperplasia 2 (5%)
Pituitary Gland (50) (50) (50) (49)
Cyst 3 (6%) 1 (2%) 3 (6%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 3 (6%) 4 (8%) 4 (8%) 7 (14%)
Thyroid Gland (50) (50) (49) (49)
C-Cell, Hyperplasia 3 (6%) 4 (8%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (50)
Cyst 1 (2%)
Hyperplasia 4 (8%) 7 (14%) 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Ovary (50) (50) (50) (49)
Cyst 2 (4%) 3 (6%) 7 (14%) 3 (6%)
Cyst, Multiple 1 (2%)
Bilateral, Cyst 1 (2%)
Oviduct (1)
Cyst 1 (100%)
Uterus (50) (50) (50) (50)
Cyst 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hydrometra 1 (2%)
Cervix, Myometrium, Hypertrophy 1 (2%)
Vagina (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Fibrosis 2 (4%)
Lymph Node, Bronchial (46) (46) (48) (42)
Fibrosis 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Fibrosis 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%) 1 (2%)
Fibrosis 5 (10%) 7 (14%) 8 (16%) 4 (8%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Thymus (50) (50) (50) (49)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 2 (4%) 2 (4%)
Hyperplasia 1 (2%)
Metaplasia, Squamous 1 (2%)
Epithelium, Hyperplasia 2 (4%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperkeratosis 2 (4%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Hair Follicle, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteopetrosis 1 (2%)
Sternum, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Hemorrhage 3 (6%) 1 (2%) 7 (14%) 3 (6%)
Hydrocephalus 10 (20%) 10 (20%) 7 (14%) 2 (4%)
Spinal Cord (1) (2) (4)
Demyelination 2 (100%) 2 (50%)
Neuron, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (50) (50) (49)
Foreign Body 4 (8%) 3 (6%) 2 (4%) 6 (12%)
Epiglottis, Inflammation, Suppurative 1 (2%) 2 (4%) 5 (10%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Glands, Inflammation 20 (41%) 16 (32%) 18 (36%) 19 (39%)
Squamous Epithelium, Hyperplasia 5 (10%) 1 (2%) 1 (2%)
Lung (50) (50) (50) (49)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Necrosis 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 4 (8%) 2 (4%) 4 (8%)
Alveolus, Emphysema 2 (4%)
Alveolus, Hemorrhage 1 (2%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 29 (58%) 24 (48%) 22 (44%) 35 (71%)
Alveolus, Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%)
Interstitium, Fibrosis 9 (18%) 13 (26%) 17 (34%) 24 (49%)
Venule, Thrombosis 1 (2%)
Nose (50) (50) (50) (49)
Concretion 2 (4%)
Foreign Body 5 (10%) 3 (6%) 2 (4%)
Goblet Cell, Respiratory Epithelium,
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Hyperplasia 1 (2%) 3 (6%) 5 (10%) 8 (16%)
Nasolacrimal Duct, Inflammation 4 (8%) 2 (4%) 2 (4%) 1 (2%)
Olfactory Epithelium, Atrophy 2 (4%)
Olfactory Epithelium, Degeneration, Hyaline 4 (8%) 5 (10%) 12 (24%) 15 (31%)
Olfactory Epithelium, Inflammation 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 6 (12%) 15 (30%) 29 (59%)
Respiratory Epithelium, Inflammation 5 (10%) 9 (18%) 26 (52%) 42 (86%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) 11 (22%) 16 (33%)
Septum, Respiratory Epithelium, Ulcer 1 (2%)
Squamous Epithelium, Hyperplasia 3 (6%) 15 (30%) 29 (58%) 45 (92%)
Squamous Epithelium, Inflammation 6 (12%) 26 (52%) 42 (84%) 48 (98%)
Pleura (2)
Hyperplasia, Focal 1 (50%)
Inflammation, Chronic 1 (50%)
Trachea (49) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (3)
Atrophy 1 (50%)
Cataract 1 (50%) 1 (50%) 3 (100%)
Degeneration 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 1 (2%)
Mineralization 1 (2%)
Nephropathy, Chronic 38 (78%) 42 (84%) 37 (74%) 33 (66%)
Pelvis, Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 33 30 32 37
Natural Death 5 6 9 7
Survivors
Terminal Sacrifice 11 14 9 6
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Foreign Body 1 (2%)
Ulcer 1 (2%)
Intestine Large, Colon (49) (48) (48) (45)
Mineralization 1 (2%)
Parasite Metazoan 2 (4%) 3 (6%)
Muscularis, Mineralization 1 (2%)
Intestine Large, Rectum (50) (48) (49) (46)
Diverticulum 1 (2%)
Parasite Metazoan 4 (8%) 2 (4%) 3 (7%)
Intestine Large, Cecum (47) (46) (48) (45)
Parasite Metazoan 3 (6%) 1 (2%) 9 (19%) 2 (4%)
Intestine Small, Jejunum (47) (46) (43) (44)
Necrosis 1 (2%)
Intestine Small, Ileum (46) (46) (44) (44)
Inflammation, Focal, Suppurative 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%) 1 (2%) 3 (6%)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 4 (8%) 1 (2%) 1 (2%)
Clear Cell Focus, Multiple 2 (4%)
Hepatodiaphragmatic Nodule 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%) 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 7 (14%) 1 (2%) 2 (4%) 1 (2%)
Bile Duct, Hyperplasia 3 (6%) 2 (4%)
Hepatocyte, Degeneration, Focal 3 (6%) 1 (2%)
Hepatocyte, Hyperplasia 1 (2%)
Mesentery (10) (7) (6) (7)
Hemorrhage 1 (17%)
Thrombosis 1 (17%)
Fat, Necrosis 8 (80%) 6 (86%) 5 (83%) 6 (86%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (49) (50) (48)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Acinus, Atrophy 9 (18%) 3 (6%) 2 (4%) 5 (10%)
Stomach, Forestomach (49) (49) (50) (48)
Hemorrhage 1 (2%)
Inflammation, Suppurative 8 (16%) 3 (6%) 3 (6%) 5 (10%)
Mineralization 4 (8%) 1 (2%) 1 (2%)
Ulcer 5 (10%) 7 (14%) 4 (8%) 2 (4%)
Epithelium, Hyperplasia 11 (22%) 2 (4%) 2 (4%) 4 (8%)
Stomach, Glandular (49) (49) (50) (48)
Erosion 1 (2%) 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer 2 (4%)
Epithelium, Mineralization 9 (18%) 5 (10%) 3 (6%) 4 (8%)
Epithelium, Necrosis 1 (2%)
Tongue (1) (2) (1)
Hyperkeratosis 1 (50%)
Tooth (1) (8)
Degeneration 1 (100%) 8 (100%)
Inflammation 1 (13%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (45) (50) (50) (50)
Inflammation 1 (2%) 2 (4%)
Mineralization 7 (16%) 3 (6%) 1 (2%) 4 (8%)
Heart (50) (50) (50) (50)
Mineralization 6 (12%) 2 (4%) 1 (2%) 4 (8%)
Atrium, Thrombosis 3 (6%) 2 (4%) 1 (2%)
Myocardium, Fibrosis 12 (24%) 10 (20%) 8 (16%) 7 (14%)
Myocardium, Ventricle, Hypertrophy 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Accessory Adrenal Cortical Nodule 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Vacuolization Cytoplasmic 9 (18%) 6 (12%) 8 (16%) 2 (4%)
Adrenal Medulla (50) (50) (50) (49)
Hyperplasia 12 (24%) 9 (18%) 6 (12%) 2 (4%)
Bilateral, Hyperplasia 1 (2%)
Islets, Pancreatic (50) (49) (50) (48)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (42) (38) (45) (41)
Hyperplasia 7 (17%) 7 (18%) 1 (2%) 3 (7%)
Pituitary Gland (50) (49) (50) (50)
Cyst 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 3 (6%) 3 (6%)
Pars Distalis, Hyperplasia 6 (12%) 5 (10%) 4 (8%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 6 (12%) 2 (4%) 8 (16%) 5 (10%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Inflammation 1 (2%)
Spermatocele 1 (2%)
Preputial Gland (50) (50) (50) (50)
Cyst 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Inflammation, Suppurative 5 (10%) 2 (4%) 3 (6%) 1 (2%)
Prostate (50) (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%)
Inflammation 9 (18%) 4 (8%) 5 (10%) 3 (6%)
Seminal Vesicle (50) (50) (50) (49)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 3 (6%) 1 (2%)
Testes (50) (50) (50) (50)
Arteriole, Inflammation 1 (2%)
Bilateral, Interstitial Cell, Hyperplasia 4 (8%) 1 (2%) 4 (8%)
Germinal Epithelium, Atrophy 12 (24%) 9 (18%) 13 (26%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Fibrosis 7 (14%) 5 (10%) 2 (4%) 3 (6%)
Lymph Node, Bronchial (39) (42) (40) (42)
Fibrosis 1 (3%) 1 (2%)
Lymph Node, Mandibular (47) (48) (49) (49)
Hyperplasia 1 (2%)
Lymph Node, Mediastinal (47) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%)
Fibrosis 15 (30%) 15 (30%) 16 (32%) 9 (18%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Infarct 3 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50) (50)
Galactocele 2 (4%) 1 (2%) 5 (10%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2 (4%) 2 (4%)
Hyperkeratosis 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Tibia, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 3 (6%) 4 (8%) 10 (20%) 1 (2%)
Hydrocephalus 5 (10%) 7 (14%) 10 (20%) 5 (10%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Foreign Body 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Epiglottis, Inflammation, Suppurative 1 (2%) 1 (2%)
Glands, Inflammation 28 (56%) 18 (36%) 18 (36%) 26 (52%)
Squamous Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Lung (50) (50) (50) (50)
Inflammation 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (18%) 3 (6%) 5 (10%) 4 (8%)
Alveolus, Emphysema 1 (2%)
Alveolus, Hemorrhage 3 (6%) 2 (4%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolus, Infiltration Cellular, Histiocyte 23 (46%) 15 (30%) 14 (28%) 11 (22%)
Alveolus, Inflammation, Suppurative 2 (4%) 2 (4%)
Alveolus, Metaplasia, Osseous 1 (2%) 1 (2%)
Alveolus, Mineralization 4 (8%) 3 (6%) 1 (2%) 4 (8%)
Bronchiole, Foreign Body 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Inflammation, Suppurative 1 (2%)
Interstitium, Fibrosis 8 (16%) 14 (28%) 17 (34%) 7 (14%)
Nose (50) (50) (50) (50)
Foreign Body 2 (4%) 2 (4%) 1 (2%)
Goblet Cell, Respiratory Epithelium,
Hyperplasia 1 (2%) 6 (12%) 6 (12%)
Nasolacrimal Duct, Inflammation 3 (6%)
Olfactory Epithelium, Atrophy 4 (8%)
Olfactory Epithelium, Degeneration, Hyaline 4 (8%) 8 (16%) 9 (18%) 14 (28%)
Olfactory Epithelium, Foreign Body 1 (2%) 1 (2%)
Olfactory Epithelium, Hyperplasia 1 (2%)
Olfactory Epithelium, Inflammation 1 (2%) 1 (2%) 1 (2%)
Respiratory Epithelium, Hyperplasia 6 (12%) 5 (10%) 17 (34%) 35 (70%)
Respiratory Epithelium, Inflammation 17 (34%) 10 (20%) 25 (50%) 43 (86%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 2 (4%) 11 (22%) 24 (48%)
Squamous Epithelium, Foreign Body 1 (2%)
Squamous Epithelium, Hyperplasia 3 (6%) 11 (22%) 39 (78%) 48 (96%)
Squamous Epithelium, Inflammation 6 (12%) 17 (34%) 41 (82%) 49 (98%)
Pleura (2)
Inflammation, Suppurative 1 (50%)
Trachea (50) (50) (50) (50)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (3)
Cataract 1 (100%) 3 (100%) 2 (67%)
Inflammation, Suppurative 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 2 (4%) 1 (2%) 2 (4%)
Infarct 1 (2%)
Mineralization 3 (6%) 1 (2%)
Nephropathy, Chronic 43 (86%) 48 (96%) 48 (96%) 38 (76%)
Papilla, Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Pelvis, Dilatation 1 (2%)
Pelvis, Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Atrophy 1 (2%)
Renal Tubule, Atypia Cellular 1 (2%)
Renal Tubule, Regeneration 1 (2%)
Urinary Bladder (50) (49) (50) (48)
Inflammation, Suppurative 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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