TDMS Study 05184-05 Pathology Tables
NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 2 YEAR CHRONIC Facility: Battelle Northwest Chemical CAS #: 111-30-8 Lock Date: 07/28/97 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7| DAY ON TEST | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3| | 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + + + + | Sarcoma | X | __________________________________________________________________________| Oral Mucosa | | Gingival, Squamous Cell Carcinoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7| DAY ON TEST | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3| | 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa-Theca Tumor Malignant | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X X | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | | Iliac, Sarcoma, Metastatic, Skin | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X | Sarcoma, Metastatic, Skin | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Sarcoma, Metastatic, Skin | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | Keratoacanthoma | X | Lip, Squamous Cell Carcinoma | | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandible, Squamous Cell Carcinoma, | | Metastatic, Skin | | Mandible, Squamous Cell Carcinoma, | | Metastatic, Oral Mucosa | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7| DAY ON TEST | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3| | 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Skeletal Muscle | | Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Sarcoma, Metastatic, Mesentery | X | Sarcoma, Metastatic, Skin | | Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| | DAY ON TEST | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3| | | 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X| 17 | __________________________________________________________________________|____________| Mesentery | + + + + + + | 10 | Sarcoma | X | 2 | __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Gingival, Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + M M + M + + M + + M M M + + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X| 37 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| | DAY ON TEST | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3| | | 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | Adenoma | X | 3 | Carcinoma | X X | 3 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa-Theca Tumor Malignant | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Stromal | X X X | 8 | __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Lymph Node | + + | 2 | Iliac, Sarcoma, Metastatic, Skin | X | 1 | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M M + + + + + + + + + + + + + + + + + + M +| 46 | Leukemia Mononuclear | X X | 4 | Sarcoma, Metastatic, Skin | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X| 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | Sarcoma, Metastatic, Skin | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 18 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X X X X | 5 | Fibroadenoma | X X X X X X X X X | 15 | Fibroadenoma, Multiple | X X X X X X X| 9 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| | DAY ON TEST | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3| | | 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Keratoacanthoma | X | 2 | Lip, Squamous Cell Carcinoma | X | 1 | Subcutaneous Tissue, Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandible, Squamous Cell Carcinoma, | | | Metastatic, Skin | X | 1 | Mandible, Squamous Cell Carcinoma, | | | Metastatic, Oral Mucosa | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 8 | Sarcoma, Metastatic, Mesentery | | 1 | Sarcoma, Metastatic, Skin | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 18 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2| | 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + M M M + + M + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X | Pars Distalis, Leukemia Mononuclear | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2| | 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Lymph Node | + | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | X | Thoracic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X X X X X X | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | X X X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Benign | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2| | 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pleura | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3| | | 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 20 | __________________________________________________________________________|____________| Mesentery | + + + | 9 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tongue | +| 1 | __________________________________________________________________________|____________| Tooth | + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + M + + + M + M + + + + + + M + +| 39 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| 37 | Pars Distalis, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X | 1 | C-Cell, Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3| | | 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 3 | Carcinoma | X X | 2 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Polyp Stromal | X X X X| 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 10 | __________________________________________________________________________|____________| Lymph Node | + + | 3 | Iliac, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X X | 2 | Renal, Leukemia Mononuclear | | 1 | Thoracic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + M + + + M + + +| 46 | Leukemia Mononuclear | X X X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 20 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 8 | Fibroadenoma | X X X X X X X X X X X| 18 | Fibroadenoma, Multiple | X | 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Schwannoma Benign | X | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3| | | 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 15 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pleura | + + | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5| DAY ON TEST | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0| | 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | Rhabdomyosarcoma, Metastatic, | | Skeletal Muscle | | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5| DAY ON TEST | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0| | 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Granulosa-Theca Tumor Malignant | X | __________________________________________________________________________| Oviduct | + | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Deciduoma Benign | | Polyp Stromal | X X X X X | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + | Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Fibroadenoma | X X X X X | Fibroadenoma, Multiple | X X X | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5| DAY ON TEST | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0| | 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| | DAY ON TEST | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3| | | 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 25 | Rhabdomyosarcoma, Metastatic, | | | Skeletal Muscle | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + + +| 7 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X| 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + + M M + + + + M + + + + + + + +| 44 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X | 27 | __________________________________________________________________________|____________| Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | +| 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| | DAY ON TEST | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3| | | 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa-Theca Tumor Malignant | | 1 | __________________________________________________________________________|____________| Oviduct | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Deciduoma Benign | X | 1 | Polyp Stromal | X X X | 8 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node | + + | 3 | Iliac, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + + + + + + M + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 10 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 25 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 3 | Fibroadenoma | X X X X X X X X X X | 15 | Fibroadenoma, Multiple | | 3 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| | DAY ON TEST | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3| | | 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Rhabdomyosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X | 12 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0| DAY ON TEST | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3| | 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Oral Mucosa | + | Lingual, Squamous Cell Carcinoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + M + + M M + + M + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0| DAY ON TEST | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3| | 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Serosa, Leiomyoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | | Thoracic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + M + + + M + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X X X | Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0| DAY ON TEST | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3| | 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urethra | + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6| | DAY ON TEST | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5| | | 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 12 | __________________________________________________________________________|____________| Mesentery | + | 3 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Lingual, Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tooth | + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Pheochromocytoma Malignant | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + M M M M M M + + M + + + + + + + + +| 36 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X X X X| 24 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Follicular Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6| | DAY ON TEST | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5| | | 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Carcinoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Granulosa Cell Tumor Malignant | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Stromal | X X X | 3 | Serosa, Leiomyoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Lymph Node | + + | 2 | Thoracic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M + + M M + + M + + + M M + M + + + + + +| 42 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 | Leukemia Mononuclear | X X X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 12 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | Fibroadenoma | X X X X X| 9 | Fibroadenoma, Multiple | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spinal Cord | + + + | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6| | DAY ON TEST | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5| | | 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Urethra | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6| DAY ON TEST | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8| | 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| Carcinoma, Metastatic, Pancreas | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| Mesothelioma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| Carcinoma | | Carcinoma, Metastatic, Pancreas | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + | Carcinoma, Metastatic, Pancreas | | Mesothelioma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X X X | __________________________________________________________________________| Parathyroid Gland | + M M + + + + + + + + M + M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6| DAY ON TEST | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8| | 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | M + I + + + + + + + + + + M + M + M + M M + + + M| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + M M + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | M M + + + + I + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6| DAY ON TEST | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8| | 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Trichoepithelioma | | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandible, Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Leukemia Mononuclear | X X X X X | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pleura | + + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| | DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| | | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Pancreas | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + A + + + + + + + + + + + + + + + + +| 47 | Mesothelioma Malignant, Metastatic, | | | Mesentery | X | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + A + + + + + + + +| 47 | Carcinoma | X | 1 | Carcinoma, Metastatic, Pancreas | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A + A + + + + + + + + A + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 21 | __________________________________________________________________________|____________| Mesentery | + + + + + +| 10 | Carcinoma, Metastatic, Pancreas | X | 1 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Complex | X | 1 | Pheochromocytoma Benign | X | 2 | Bilateral, Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| | DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| | | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Adenoma | | 1 | Carcinoma | | 4 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + M + + + + + + + + + + + + M + + M +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| 32 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X | 1 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pancreas | X | 1 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pancreas | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X | 26 | Interstitial Cell, Adenoma | X X| 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 12 | __________________________________________________________________________|____________| Lymph Node | + | 1 | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + + + + + M + + + + + M + + + + + + + +| 39 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pancreas | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| | DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| | | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 21 | Mesothelioma Malignant, Metastatic, | | | Mesentery | X | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X | 1 | Fibroadenoma | X| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 1 | Trichoepithelioma | X | 1 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | X X | 4 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandible, Osteosarcoma | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pancreas | X | 1 | Leukemia Mononuclear | X X X X | 9 | Osteosarcoma, Metastatic, Bone | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pleura | | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| | DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| | | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 21 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6| DAY ON TEST | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8| | 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X X | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Malignant| X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + M + M + M M + + M M + + + M + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X| C-Cell, Carcinoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6| DAY ON TEST | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8| | 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Organ of Zuckerkandl, Paraganglioma | | Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node | + + | Iliac, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | M M + + + + M + + + + + + + + + + M + + + + M + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + M + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Fibroma | X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6| DAY ON TEST | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8| | 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Keratoacanthoma | X X | Sebaceous Gland, Carcinoma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Skin | X | Fibrosarcoma, Metastatic, Skin | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Lacrimal Gland | | __________________________________________________________________________| Zymbal's Gland | | Adenoma | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6| | DAY ON TEST | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1| | | 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A A + + + + + + A + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A A + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A A + + + + + + A + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A A + + + + + + A + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X| 22 | __________________________________________________________________________|____________| Mesentery | + + | 7 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Tongue | + + | 2 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 2 | Pheochromocytoma Benign | X | 4 | Bilateral, Pheochromocytoma Malignant| | 1 | Bilateral, Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X | 3 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + M M + + + M M + + M + + + + +| 38 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X | 26 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6| | DAY ON TEST | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1| | | 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Carcinoma | X | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 2 | Organ of Zuckerkandl, Paraganglioma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + | 2 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Carcinoma | X X| 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X| 32 | Interstitial Cell, Adenoma | X X X X X | 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 15 | __________________________________________________________________________|____________| Lymph Node | + + | 4 | Iliac, Leukemia Mononuclear | X | 1 | Inguinal, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X X | 3 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + M + + M + + + + + + + + + + + + M| 42 | Leukemia Mononuclear | X X X X X X X X | 11 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X X X | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X | 12 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X| 24 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6| | DAY ON TEST | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1| | | 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 2 | Fibroadenoma | X | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | | 1 | Fibroma | | 2 | Keratoacanthoma | X X X | 5 | Sebaceous Gland, Carcinoma | | 1 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 2 | Subcutaneous Tissue, Leukemia | | | Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Skin | | 1 | Fibrosarcoma, Metastatic, Skin | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 18 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 3 | __________________________________________________________________________|____________| Lacrimal Gland | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + + + | 3 | Adenoma | X | 1 | Carcinoma | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6| | DAY ON TEST | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1| | | 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Renal Tubule, Adenoma | X | 3 | __________________________________________________________________________|____________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X| 24 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7| DAY ON TEST | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2| | 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + A + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + +| __________________________________________________________________________| Oral Mucosa | + | Squamous Cell Carcinoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7| DAY ON TEST | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2| | 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Lymph Node | | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + M + + + + + + M M + + + + + M + + + + + + M| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Squamous Cell Papilloma | X | Lip, Basal Cell Adenoma | | Subcutaneous Tissue, Lipoma | | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7| DAY ON TEST | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2| | 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma, | | Multiple | | Leukemia Mononuclear | X X X X X X X X X X X | Sarcoma Stromal, Metastatic, Kidney | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Stromal Nephroma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Papilloma | X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6| | DAY ON TEST | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3| | | 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + A + + + + A + A + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + A + + + + A + A + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 25 | __________________________________________________________________________|____________| Mesentery | + +| 6 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 2 | Pheochromocytoma Complex | X | 1 | Pheochromocytoma Benign | X X X X | 6 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + M + M + + + M + + + + + + + + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X | 26 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6| | DAY ON TEST | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3| | | 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + | 1 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X | 27 | Interstitial Cell, Adenoma | X X X X X X X X X X X| 13 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 17 | __________________________________________________________________________|____________| Lymph Node | + | 1 | Pancreatic, Leukemia Mononuclear | X | 1 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + + + M M + + M + + + + + + + M + + + + +| 40 | Leukemia Mononuclear | X X | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 11 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 12 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 11 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 25 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 2 | Squamous Cell Papilloma | | 1 | Lip, Basal Cell Adenoma | X | 1 | Subcutaneous Tissue, Lipoma | X | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6| | DAY ON TEST | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3| | | 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Leukemia Mononuclear | X X X X X X X | 18 | Sarcoma Stromal, Metastatic, Kidney | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 3 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Stromal Nephroma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6| DAY ON TEST | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3| | 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + A + A A + + + + A + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + A + A A + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + A A + + + + A + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + A A + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + A A + + + + A + + + + + + + A + + + +| Mesothelioma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Intestine Small, Ileum | + + + + A + A A + + + + A + + + + + + + A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Mesentery | | Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + A A + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + A + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + A + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | __________________________________________________________________________| Tooth | + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + A A + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | M + + + M + + M M M M + + + + + M + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X| Pars Intermedia, Adenoma | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6| DAY ON TEST | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3| | 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node | + | Lumbar, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X | Renal, Iliac, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | M + M M M + M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Mesothelioma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 _____________________________________________________________________________________________________________________ | 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6| DAY ON TEST | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3| | 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Keratoacanthoma | | Squamous Cell Carcinoma | X | Pinna, Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Renal Tubule, Adenoma | | Renal Tubule, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + A A + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7| | DAY ON TEST | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1| | | 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 44 | Mesothelioma Malignant, Metastatic, | | | Mesentery | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 15 | __________________________________________________________________________|____________| Mesentery | + + + + + + + | 7 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Pharyngeal, Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Mesothelioma Malignant, Metastatic, | | | Mesentery | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Tooth | + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X| 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | | 1 | Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7| | DAY ON TEST | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1| | | 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 41 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X | 20 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 1 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X| 25 | Interstitial Cell, Adenoma | X X X X | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 13 | __________________________________________________________________________|____________| Lymph Node | + + +| 4 | Lumbar, Leukemia Mononuclear | X| 1 | Pancreatic, Leukemia Mononuclear | X | 2 | Renal, Iliac, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + + + + + + M + + + + M + + + + + + + +| 42 | Leukemia Mononuclear | X X X X| 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X| 8 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 5 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7| | DAY ON TEST | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1| | | 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Mesothelioma Malignant, Metastatic, | | | Mesentery | X | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Fibroadenoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 1 | Squamous Cell Carcinoma | | 1 | Pinna, Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | X X X X X X X| 12 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Renal Tubule, Adenoma | X | 1 | Renal Tubule, Carcinoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:20:53 __________________________________________________________________________________________________________________________________ | 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7| | DAY ON TEST | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1| | | 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 16 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------