TDMS Study 05184-05 Pathology Tables
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
2 YEAR CHRONIC
Facility: Battelle Northwest
Chemical CAS #: 111-30-8
Lock Date: 07/28/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 22 17 32 34
Natural Death 2 2 3 2
Survivors
Terminal Sacrifice 26 31 15 14
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (49)
Liver (50) (50) (50) (50)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Mesentery (10) (9) (7) (3)
Sarcoma 2 (20%)
Oral Mucosa (1) (1)
Gingival, Squamous Cell Carcinoma 1 (100%)
Lingual, Squamous Cell Carcinoma 1 (100%)
Pancreas (50) (50) (50) (50)
Stomach, Glandular (49) (49) (50) (50)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Adrenal Medulla (50) (50) (50) (49)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (50) (50) (50) (49)
Pars Distalis, Adenoma 37 (74%) 37 (74%) 27 (54%) 24 (49%)
Thyroid Gland (50) (50) (49) (49)
C-Cell, Adenoma 2 (4%) 1 (2%) 2 (4%)
C-Cell, Carcinoma 2 (4%)
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicular Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (50)
Adenoma 3 (6%) 3 (6%) 1 (2%)
Carcinoma 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Ovary (50) (50) (50) (49)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%) 1 (2%)
Uterus (50) (50) (50) (50)
Deciduoma Benign 1 (2%)
Polyp Stromal 8 (16%) 10 (20%) 8 (16%) 3 (6%)
Sarcoma Stromal 1 (2%)
Serosa, Leiomyoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (2) (3) (3) (2)
Iliac, Sarcoma, Metastatic, Skin 1 (50%)
Lymph Node, Bronchial (46) (46) (48) (42)
Sarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mandibular (48) (49) (48) (46)
Lymph Node, Mesenteric (50) (50) (50) (50)
Lymph Node, Mediastinal (50) (50) (50) (49)
Sarcoma, Metastatic, Skin 1 (2%)
Spleen (50) (50) (50) (50)
Thymus (50) (50) (50) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Carcinoma 5 (10%) 8 (16%) 3 (6%) 1 (2%)
Fibroadenoma 15 (30%) 18 (36%) 15 (30%) 9 (18%)
Fibroadenoma, Multiple 9 (18%) 5 (10%) 3 (6%) 1 (2%)
Skin (50) (50) (50) (50)
Fibroma 1 (2%)
Fibrosarcoma 1 (2%)
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Keratoacanthoma 2 (4%)
Schwannoma Benign 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Lip, Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Mandible, Squamous Cell Carcinoma,
Metastatic, Skin 1 (2%)
Mandible, Squamous Cell Carcinoma,
Metastatic, Oral Mucosa 1 (2%)
Skeletal Muscle (1) (1)
Rhabdomyosarcoma 1 (100%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Alveolar/Bronchiolar Adenoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 18 (36%) 20 (40%) 25 (50%) 12 (24%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 46 49 36
Total Primary Neoplasms 110 111 95 57
Total Animals with Benign Neoplasms 42 43 40 31
Total Benign Neoplasms 77 77 61 40
Total Animals with Malignant Neoplasms 27 26 29 16
Total Malignant Neoplasms 33 34 34 17
Total Animals with Metastatic Neoplasms 4 1 1
Total Metastatic Neoplasm 9 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 33 30 32 37
Natural Death 5 6 9 7
Survivors
Terminal Sacrifice 11 14 9 6
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (48) (48) (45)
Carcinoma, Metastatic, Pancreas 1 (2%)
Intestine Large, Cecum (47) (46) (48) (45)
Intestine Small, Jejunum (47) (46) (43) (44)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Mesentery (10) (7) (6) (7)
Carcinoma, Metastatic, Pancreas 1 (10%)
Oral Mucosa (1) (1)
Squamous Cell Carcinoma 1 (100%)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (49) (50) (48)
Carcinoma 1 (2%)
Stomach, Forestomach (49) (49) (50) (48)
Squamous Cell Papilloma 1 (2%)
Tongue (1) (2) (1)
Squamous Cell Papilloma 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (49)
Pheochromocytoma Malignant 1 (2%) 2 (4%) 2 (4%) 1 (2%)
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Complex 1 (2%) 1 (2%)
Pheochromocytoma Benign 2 (4%) 4 (8%) 6 (12%) 2 (4%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Bilateral, Pheochromocytoma Benign 2 (4%) 1 (2%)
Islets, Pancreatic (50) (49) (50) (48)
Adenoma 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Carcinoma 4 (8%) 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (50) (49) (50) (50)
Pars Distalis, Adenoma 32 (64%) 26 (53%) 26 (52%) 20 (40%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Adenoma 1 (2%) 4 (8%) 2 (4%) 2 (4%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2)
Organ of Zuckerkandl, Paraganglioma Malignant 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Carcinoma, Metastatic, Pancreas 1 (2%)
Preputial Gland (50) (50) (50) (50)
Adenoma 1 (2%) 2 (4%)
Carcinoma 2 (4%) 1 (2%) 2 (4%)
Seminal Vesicle (50) (50) (50) (49)
Carcinoma, Metastatic, Pancreas 1 (2%)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 26 (52%) 32 (64%) 27 (54%) 25 (50%)
Interstitial Cell, Adenoma 10 (20%) 12 (24%) 13 (26%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (1) (4) (1) (4)
Lymph Node, Bronchial (39) (42) (40) (42)
Lymph Node, Mandibular (47) (48) (49) (49)
Lymph Node, Mesenteric (50) (49) (50) (50)
Carcinoma, Metastatic, Pancreas 1 (2%)
Lymph Node, Mediastinal (47) (50) (50) (50)
Spleen (50) (50) (50) (50)
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%) 2 (4%)
Fibroadenoma 1 (2%) 3 (6%) 2 (4%) 2 (4%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Fibroma 2 (4%)
Keratoacanthoma 1 (2%) 5 (10%) 2 (4%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%)
Lip, Basal Cell Adenoma 1 (2%)
Pinna, Squamous Cell Papilloma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Sebaceous Gland, Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Mandible, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Carcinoma, Metastatic, Skin 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Sarcoma Stromal, Metastatic, Kidney 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (3) (1)
Adenoma 1 (33%)
Carcinoma 1 (100%) 2 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Stromal Nephroma 1 (2%)
Renal Tubule, Adenoma 3 (6%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (49) (50) (48)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 21 (42%) 24 (48%) 25 (50%) 16 (32%)
Mesothelioma Malignant 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05184-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:27:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 250 PPB 500 PPB 750 PPB
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 38
Total Primary Neoplasms 118 144 120 92
Total Animals with Benign Neoplasms 48 48 50 38
Total Benign Neoplasms 84 103 86 68
Total Animals with Malignant Neoplasms 28 33 31 19
Total Malignant Neoplasms 34 41 34 24
Total Animals with Metastatic Neoplasms 3 2 1 1
Total Metastatic Neoplasm 10 2 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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