TDMS Study 05184-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest GLUTARALDEHYDE DATE: 09/14/98
EXPERIMENT: 05184 TEST: 05 TIME: 08:32:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55425C
PATHOLOGIST: RENNE, ROGER CAS: 111-30-8
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest GLUTARALDEHYDE DATE: 09/14/98
EXPERIMENT: 05184 TEST: 05 TIME: 08:32:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55425C
PATHOLOGIST: RENNE, ROGER CAS: 111-30-8
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 117 392 452 495 498 502 514 543 544 555 |
| 556 580 583 583 601 602 602 612 612 617 |
| 637 637 638 652 652 652 657 676 689 689 |
| 694 694 702 702 708 708 717 717 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 356 449 495 533 550 569 577 579 607 613 |
| 615 617 621 625 632 634 638 647 652 654 |
| 666 666 671 675 689 694 694 694 708 708 |
| 708 712 712 712 716 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 41 CENSORED DEATHS 0 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 365 393 481 512 524 525 526 526 533 561 |
| 581 587 593 608 609 612 617 617 632 638 |
| 645 652 652 654 656 661 664 666 682 686 |
| 688 688 689 689 702 705 708 711 716 721 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 750 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 44 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 23 99 100 105 106 106 106 107 111 262 |
| 393 449 468 474 492 502 508 561 564 586 |
| 589 589 593 603 608 620 625 634 638 638 |
| 646 652 666 673 683 689 708 708 708 712 |
| 716 718 720 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 96.0 94.0 82.0 66.0 46.0 24.0 |
| | |
| | |
|250 PPB | 100.0 100.0 100.0 98.0 98.0 96.0 92.0 84.0 60.0 28.0 |
| | |
| | |
|500 PPB | 100.0 100.0 100.0 98.0 96.0 94.0 82.0 74.0 46.0 18.0 |
| | |
| | |
|750 PPB | 98.0 82.0 80.0 80.0 78.0 72.0 66.0 52.0 36.0 12.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 250 PPB 500 PPB 750 PPB |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 24.0% 28.0% 18.0% 12.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.032 ----- P=0.788 P=0.094 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 599.5 633.7 619.5 499.5 |
|NATURAL DEATHS (C) | (18.4) (13.5) (13.5) (34.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 630.6 660.4 639.2 527.1 |
|(STANDARD ERROR) | (16.0) (11.5) (12.5) (32.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 119 518 533 542 550 566 589 589 589 598 |
| 638 651 660 666 674 680 680 682 694 698 |
| 703 708 712 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 117 178 437 542 561 561 589 593 606 612 |
| 615 617 666 674 675 694 720 724 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 276 355 357 455 469 508 513 533 533 543 |
| 544 558 583 589 614 617 617 619 634 638 |
| 638 654 660 662 674 674 676 676 680 703 |
| 709 711 715 716 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 750 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 32 106 108 113 113 117 253 375 432 463 |
| 474 474 512 514 516 528 567 569 583 628 |
| 630 641 652 654 654 654 677 680 698 702 |
| 708 716 716 717 718 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 98.0 98.0 92.0 80.0 74.0 52.0 |
| | |
| | |
|250 PPB | 100.0 96.0 96.0 96.0 96.0 94.0 92.0 84.0 76.0 62.0 |
| | |
| | |
|500 PPB | 100.0 100.0 100.0 94.0 94.0 90.0 78.0 72.0 52.0 30.0 |
| | |
| | |
|750 PPB | 98.0 88.0 86.0 86.0 84.0 76.0 68.0 62.0 48.0 28.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 250 PPB 500 PPB 750 PPB |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.0% 62.0% 30.0% 28.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 ----- P=0.023 P=0.008 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 615.0 574.1 595.1 511.5 |
|NATURAL DEATHS (C) | (25.2) (38.3) (18.7) (36.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 674.8 670.7 635.5 572.7 |
|(STANDARD ERROR) | (14.5) (17.9) (15.7) (29.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GLUTARALDEHYDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
250 PPB = 2
500 PPB = 3
750 PPB = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 2 3
| 4 4 1 2 3 13 2
| 13 1 3 1 3 2
| 44 11 3 3 2 2
90 + 2 2
| 1 1 33 22
| 1 331 2 2
| 4 4 31 13 22
80 + 4 4 3 3
| 4 4 1 13 22
P | 4 44 11 3 3 22
E | 4 4 1 1 22
R 70 + 44 33
C | 44 33 22
E | 4 4 1 13 3222
N | 4 4 11 33
T 60 + 4 4 1 1332 2
| 33
S | 4 4 11 1 22
U | 2 2
R 50 + 4 4 3 3 22
V | 44
I | 444 1 331312 2
V |
A 40 + 44 311
L | 44
| 4 44 11
| 443 112
30 + 44 22
| 4 3112 2
| 31 1
|
20 + 433
| 3 3
|
| 4 4
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 25 obs hidden.
GLUTARALDEHYDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
250 PPB = 2
500 PPB = 3
750 PPB = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 3
| 4 41 2 3 3 1
| 44 2 3 2 3 1 11
| 3 3 11 2
90 + 3 3 1 1
| 4 4 33 1 1
| 4 4 4 3 3 2 2
| 4 4 33 1122
P 80 + 44 1 1
E | 3 3 22 11
R | 4 4 3 3 3 2 1 112
C | 3 3 11
E 70 + 4 4 33 11 2
N | 4 4 2 2
T | 44 4 3 3 1 1 22
| 4 433 2 2
S 60 + 11
U | 4 3 3 11
R | 4 3 3 1 1
V | 3 3 1 1
I 50 +
V | 4 4
A | 33 4
L | 3 43
40 + 33
| 44
| 33
| 33
30 + 3 3
| 4 4
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 26 obs hidden.