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TDMS Study 05184-06 Pathology Tables

NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51

                                                           CORE STUDY




       Facility:  Battelle Northwest

       Chemical CAS #:  111-30-8

       Lock Date:  07/01/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           10           10           12                                     
    Natural Death                                      5            3            4            6                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           37           35           32                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (41)         (43)         (41)                                   
      Hyperplasia                                                                             1 (2%)                                
   Intestine Small, Duodenum                          (45)         (47)         (48)         (48)                                   
      Necrosis                                         1 (2%)       1 (2%)                                                          
   Liver                                              (50)         (48)         (50)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Basophilic Focus                                 2 (4%)       4 (8%)       5 (10%)      2 (4%)                                
      Clear Cell Focus                                 2 (4%)       1 (2%)                                                          
      Eosinophilic Focus                               6 (12%)      6 (13%)      4 (8%)                                             
      Fatty Change                                                               3 (6%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Necrosis                                         1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Tension Lipidosis                                1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                    2 (4%)       1 (2%)                                
   Mesentery                                          (12)         (6)          (5)          (6)                                    
      Inflammation, Suppurative                        1 (8%)                                 1 (17%)                               
      Thrombosis                                       1 (8%)       1 (17%)                   1 (17%)                               
      Artery, Inflammation, Chronic Active             2 (17%)                                                                      
      Fat, Necrosis                                    9 (75%)      5 (83%)      3 (60%)      4 (67%)                               
   Pancreas                                           (50)         (48)         (49)         (49)                                   
      Atrophy                                                       1 (2%)                                                          
      Basophilic Focus                                 1 (2%)       1 (2%)                                                          
      Hypertrophy                                                                1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Duct, Cyst                                       1 (2%)                    2 (4%)                                             
   Stomach, Forestomach                               (50)         (49)         (48)         (48)                                   
      Hyperplasia, Squamous                            1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)       2 (4%)                                             
   Stomach, Glandular                                 (50)         (48)         (48)         (48)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Mineralization                                   1 (2%)       1 (2%)                    1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
   Tooth                                                           (1)                       (1)                                    
      Developmental Malformation                                    1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)         (50)                                   
      Artery, Inflammation                             1 (2%)                                                                       
      Atrium, Thrombosis                               2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia                                      2 (4%)       2 (4%)       7 (14%)      1 (2%)                                
      Hypertrophy                                      2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Capsule, Inflammation, Chronic Active            1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (48)         (49)                                   
      Hyperplasia                                      3 (6%)       1 (2%)       5 (10%)      1 (2%)                                
   Islets, Pancreatic                                 (50)         (48)         (49)         (49)                                   
      Hyperplasia                                      1 (2%)                    2 (4%)       1 (2%)                                
   Pituitary Gland                                    (49)         (49)         (49)         (50)                                   
      Pars Distalis, Hyperplasia                      19 (39%)     24 (49%)     23 (47%)     28 (56%)                               
      Pars Intermedia, Hypertrophy                                               1 (2%)                                             
   Thyroid Gland                                      (50)         (48)         (50)         (50)                                   
      Follicular Cell, Hyperplasia                    26 (52%)     24 (50%)     30 (60%)     37 (74%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (47)         (49)         (50)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Cyst                                            16 (33%)     12 (26%)     18 (37%)     18 (36%)                               
      Inflammation, Suppurative                        1 (2%)                                 1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
   Uterus                                             (50)         (48)         (49)         (49)                                   
      Angiectasis                                      2 (4%)       1 (2%)       1 (2%)                                             
      Cyst                                             1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                                 1 (2%)                                             
      Hydrometra                                       3 (6%)       7 (15%)      3 (6%)       5 (10%)                               
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Infiltration Cellular, Polymorphonuclear         3 (6%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Myometrium, Hyperplasia                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (48)         (50)         (49)                                   
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
   Lymph Node                                         (7)          (4)          (3)          (1)                                    
      Iliac, Infiltration Cellular, Plasma Cell        1 (14%)                                                                      
      Lumbar, Hyperplasia, Lymphoid                                 1 (25%)                                                         
      Lumbar, Inflammation, Suppurative                                                       1 (100%)                              
      Renal, Infiltration Cellular, Plasma Cell        1 (14%)                                                                      
   Lymph Node, Bronchial                              (29)         (32)         (37)         (36)                                   
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
      Infiltration Cellular, Plasma Cell               2 (7%)                                                                       
   Lymph Node, Mandibular                             (43)         (40)         (39)         (38)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (47)         (48)         (46)         (46)                                   
      Ectasia                                          1 (2%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            4 (9%)                    1 (2%)                                             
   Lymph Node, Mediastinal                            (31)         (23)         (34)         (37)                                   
      Hemorrhage                                                                 1 (3%)                                             
      Hyperplasia, Lymphoid                            1 (3%)                                                                       
      Infiltration Cellular, Plasma Cell               1 (3%)                                                                       
      Inflammation, Suppurative                                                               1 (3%)                                
   Spleen                                             (50)         (48)         (48)         (49)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Hematopoietic Cell Proliferation                11 (22%)      8 (17%)      8 (17%)     12 (24%)                               
      Hyperplasia, Lymphoid                            4 (8%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Suppurative                                                               1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)                                                              
      Hemorrhage                                       1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Degeneration                                     1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Artery, Inflammation                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (50)         (48)                                   
      Inflammation                                                               1 (2%)                                             
      Epiglottis, Hyperplasia                                                    1 (2%)                                             
      Epiglottis, Metaplasia, Squamous                              1 (2%)       1 (2%)                                             
   Lung                                               (50)         (49)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (2%)                                
      Thrombosis                                       1 (2%)                    2 (4%)                                             
      Alveolar Epithelium, Hyperplasia                 4 (8%)       4 (8%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                                 1 (2%)                                
      Mediastinum, Inflammation, Suppurative           1 (2%)                                                                       
   Nose                                               (50)         (49)         (50)         (50)                                   
      Inflammation                                     5 (10%)      7 (14%)     13 (26%)     14 (28%)                               
      Inflammation, Suppurative                        1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
      Olfactory Epithelium, Atrophy                                 1 (2%)       3 (6%)       3 (6%)                                
      Olfactory Epithelium, Degeneration, Hyaline     11 (22%)     10 (20%)     15 (30%)     10 (20%)                               
      Respiratory Epithelium, Degeneration, Hyaline   16 (32%)     35 (71%)     32 (64%)     30 (60%)                               
      Respiratory Epithelium, Metaplasia, Squamous     7 (14%)     11 (22%)     16 (32%)     21 (42%)                               
      Turbinate, Necrosis                                           3 (6%)       1 (2%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (49)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Hydronephrosis                                                             1 (2%)                                             
      Infarct                                          1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
      Metaplasia, Osseous                              1 (2%)                                 2 (4%)                                
      Nephropathy                                     20 (40%)     14 (29%)     19 (39%)     16 (33%)                               
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Renal Tubule, Necrosis                           1 (2%)                                                                       
   Urinary Bladder                                    (48)         (48)         (48)         (47)                                   
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           15            6            5                                     
    Natural Death                                      6            8            4            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           27           40           38                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (49)         (50)         (50)         (49)                                   
      Atypia Cellular, Diffuse                         1 (2%)                                                                       
      Basophilic Focus                                 5 (10%)      8 (16%)      4 (8%)       6 (12%)                               
      Clear Cell Focus                                 9 (18%)      6 (12%)      9 (18%)      7 (14%)                               
      Eosinophilic Focus                               7 (14%)      6 (12%)      5 (10%)      3 (6%)                                
      Fatty Change                                                                            2 (4%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mixed Cell Focus                                 2 (4%)       2 (4%)                                                          
      Necrosis                                         1 (2%)       1 (2%)                    2 (4%)                                
      Tension Lipidosis                                             1 (2%)                                                          
      Centrilobular, Necrosis                                       2 (4%)                    1 (2%)                                
   Mesentery                                          (2)          (2)          (3)          (5)                                    
      Artery, Mineralization                           1 (50%)                                                                      
      Fat, Necrosis                                    1 (50%)      2 (100%)     2 (67%)      5 (100%)                              
   Pancreas                                           (47)         (49)         (50)         (48)                                   
      Atrophy                                                                    1 (2%)       1 (2%)                                
      Basophilic Focus                                                                        1 (2%)                                
      Metaplasia, Hepatocyte                                                     1 (2%)       1 (2%)                                
      Duct, Cyst                                                                 1 (2%)                                             
   Stomach, Forestomach                               (48)         (49)         (50)         (48)                                   
      Diverticulum                                     1 (2%)                                                                       
      Hyperplasia, Squamous                            2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute                              2 (4%)       1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
   Stomach, Glandular                                 (46)         (47)         (50)         (48)                                   
      Infiltration Cellular, Mixed Cell                             2 (4%)                                                          
      Metaplasia, Hepatocyte                                                     1 (2%)                                             
      Necrosis                                                      1 (2%)                    1 (2%)                                
   Tooth                                              (13)         (17)         (10)         (19)                                   
      Developmental Malformation                      12 (92%)     17 (100%)    10 (100%)    19 (100%)                              
      Inflammation, Chronic Active                     2 (15%)                                1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Aorta, Mineralization                            1 (100%)                                                                     
   Heart                                              (49)         (50)         (50)         (49)                                   
      Angiectasis                                                                1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Artery, Inflammation                             1 (2%)       1 (2%)       1 (2%)                                             
      Artery, Mineralization                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (47)         (49)         (50)         (49)                                   
      Hyperplasia                                     10 (21%)      9 (18%)     18 (36%)     12 (24%)                               
      Hypertrophy                                     32 (68%)     26 (53%)     31 (62%)     34 (69%)                               
      Necrosis                                         1 (2%)                                                                       
   Adrenal Medulla                                    (47)         (49)         (50)         (49)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
      Necrosis                                         1 (2%)                                                                       
   Islets, Pancreatic                                 (47)         (48)         (50)         (48)                                   
      Hyperplasia                                      3 (6%)       2 (4%)       1 (2%)       6 (13%)                               
   Pituitary Gland                                    (46)         (47)         (48)         (47)                                   
      Pars Distalis, Hyperplasia                       2 (4%)       1 (2%)       2 (4%)       4 (9%)                                
   Thyroid Gland                                      (48)         (49)         (49)         (49)                                   
      Bilateral, Follicular Cell, Hyperplasia                                                 1 (2%)                                
      Follicular Cell, Hyperplasia                    14 (29%)      9 (18%)     11 (22%)     18 (37%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)         (50)         (50)         (49)                                   
      Granuloma Sperm                                  2 (4%)                                 1 (2%)                                
   Penis                                                                        (1)                                                 
      Inflammation, Acute                                                        1 (100%)                                           
   Preputial Gland                                    (48)         (49)         (50)         (47)                                   
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic Active                     2 (4%)       2 (4%)       2 (4%)                                             
   Prostate                                           (49)         (48)         (50)         (47)                                   
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
   Testes                                             (48)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (36)         (22)         (30)         (33)                                   
      Hyperplasia, Lymphoid                            1 (3%)                                                                       
   Lymph Node, Mesenteric                             (46)         (44)         (47)         (47)                                   
      Infiltration Cellular, Plasma Cell               1 (2%)                    1 (2%)                                             
   Lymph Node, Mediastinal                            (29)         (27)         (33)         (30)                                   
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
   Spleen                                             (48)         (48)         (50)         (48)                                   
      Hematopoietic Cell Proliferation                12 (25%)     14 (29%)     12 (24%)      7 (15%)                               
      Hyperplasia, Lymphoid                                         2 (4%)                                                          
   Thymus                                             (39)         (34)         (43)         (44)                                   
      Hyperplasia, Tubular                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (50)         (50)         (48)                                   
      Prepuce, Inflammation, Chronic Active            7 (15%)      7 (14%)      4 (8%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Demyelination, Focal                                          1 (2%)                                                          
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (47)         (49)         (50)         (50)                                   
      Glands, Inflammation                             5 (11%)      3 (6%)       3 (6%)       3 (6%)                                
   Lung                                               (48)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)       3 (6%)       5 (10%)      2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte                   1 (2%)       1 (2%)                                             
      Artery, Mediastinum, Mineralization              1 (2%)                                                                       
   Nose                                               (48)         (50)         (50)         (50)                                   
      Inflammation                                     6 (13%)      4 (8%)       3 (6%)       5 (10%)                               
      Polyp, Inflammatory                              1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation                                                         1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05184-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 07/13/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:54:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPB     125 PPB      250 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Atrophy                    1 (2%)       1 (2%)                    2 (4%)                                
      Olfactory Epithelium, Degeneration, Hyaline      1 (2%)       1 (2%)       5 (10%)      2 (4%)                                
      Olfactory Epithelium, Metaplasia                 1 (2%)                                 1 (2%)                                
      Respiratory Epithelium, Degeneration, Hyaline    5 (10%)      3 (6%)       6 (12%)     10 (20%)                               
      Respiratory Epithelium, Metaplasia, Squamous     2 (4%)       5 (10%)      6 (12%)      9 (18%)                               
      Turbinate, Necrosis                                                        2 (4%)                                             
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Inflammation, Acute                                                1 (100%)                                           
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (49)         (50)         (49)                                   
      Cyst                                                          4 (8%)       2 (4%)                                             
      Hydronephrosis                                   2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
      Inflammation                                     1 (2%)                                                                       
      Metaplasia, Osseous                                           1 (2%)       2 (4%)                                             
      Mineralization                                   1 (2%)                                                                       
      Nephropathy                                     44 (92%)     43 (88%)     46 (92%)     47 (96%)                               
      Thrombosis                                                                 1 (2%)                                             
      Glomerulus, Inflammation, Suppurative            1 (2%)       1 (2%)                                                          
      Papilla, Inflammation, Suppurative                                                      2 (4%)                                
      Renal Tubule, Necrosis                                        1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (47)         (48)         (50)         (47)                                   
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)       1 (2%)       1 (2%)       1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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