TDMS Study 05184-06 Pathology Tables
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 111-30-8
Lock Date: 07/01/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 0| 5| 3| 5| 3| 8|
| 2| 6| 5| 7| 7| 1| 7| 6| 5| 5| 7| 5| 7| 4| 6| 6| 5| 6| 2| 8| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A A + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 4 |
Necrosis | 2 |
Tension Lipidosis | |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Suppurative | 3 |
Thrombosis | |
Artery, Inflammation, Chronic Active | 3 |
Fat, Necrosis | 2 3 2 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Inflammation, Suppurative | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | |
Hypertrophy | 2 |
Capsule, Inflammation, Chronic Active| 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 0| 5| 3| 5| 3| 8|
| 2| 6| 5| 7| 7| 1| 7| 6| 5| 5| 7| 5| 7| 4| 6| 6| 5| 6| 2| 8| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M I + + M M M M M + M + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 1 1 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 2 4 2 1 1 4 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + I M M + + + + + M + + + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + I + + + + +|
Cyst | 4 2 3 3 2 3 4 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 |
Hydrometra | 2 3 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + +|
Iliac, Infiltration Cellular, Plasma | |
Cell | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M M M M + M M + M M + M + + +|
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + + M + + + + M + + M + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + M + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + + + M + + + + M + M M M M + + + + + + M +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 1 4 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 0| 5| 3| 5| 3| 8|
| 2| 6| 5| 7| 7| 1| 7| 6| 5| 5| 7| 5| 7| 4| 6| 6| 5| 6| 2| 8| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Necrosis | |
Artery, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinum, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
Inflammation, Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 2 2 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 0| 5| 3| 5| 3| 8|
| 2| 6| 5| 7| 7| 1| 7| 6| 5| 5| 7| 5| 7| 4| 6| 6| 5| 6| 2| 8| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Metaplasia, Osseous | |
Nephropathy | 3 1 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | 3 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + M + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 0| 3| 3| 0| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| |
| 7| 5| 6| 6| 1| 4| 7| 7| 7| 6| 4| 6| 5| 7| 6| 4| 7| 6| 6| 8| 6| 6| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + M M + + + + + A + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + I + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + A + + + A + + + + +| 45 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X X | 6 |
Hematopoietic Cell Proliferation | | 1 4.0|
Necrosis | | 1 2.0|
Tension Lipidosis | X | 1 |
Bile Duct, Hyperplasia | | 1 2.0|
Centrilobular, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Inflammation, Suppurative | | 1 3.0|
Thrombosis | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | 3 | 2 3.0|
Fat, Necrosis | 2 2 2 3 | 9 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation | 3 | 1 3.0|
Atrium, Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 0| 3| 3| 0| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| |
| 7| 5| 6| 6| 1| 4| 7| 7| 7| 6| 4| 6| 5| 7| 6| 4| 7| 6| 6| 8| 6| 6| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Hyperplasia | 2 2 | 2 2.0|
Hypertrophy | 1 | 2 1.5|
Capsule, Inflammation, Chronic Active| | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M M M M M + + + M + M + M M + + M M M + + +| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 1 2 3 1 3 3 4 4 2 3 2| 19 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 4 1 2 | 26 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 43 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 2 2 4 2 3 1 3 | 16 2.6|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 4 | 2 2.5|
Cyst | | 1 2.0|
Hydrometra | 2 | 3 2.3|
Infiltration Cellular, | | |
Polymorphonuclear | 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Iliac, Infiltration Cellular, Plasma | | |
Cell | 3 | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + M M M M M + + M M M + M M M + +| 29 |
Infiltration Cellular, Plasma Cell | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 0| 3| 3| 0| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| |
| 7| 5| 6| 6| 1| 4| 7| 7| 7| 6| 4| 6| 5| 7| 6| 4| 7| 6| 6| 8| 6| 6| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + M + + + + + + + +| 43 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + I + + +| 47 |
Ectasia | 4 | 1 4.0|
Hyperplasia, Lymphoid | 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + M + + M + M + M + + + M M + + M M + M| 31 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 2 3 4 2 | 11 2.9|
Hyperplasia, Lymphoid | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + M + + M + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 3.0|
Necrosis | 3 | 1 3.0|
Artery, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 3 2 | 4 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Mediastinum, Inflammation, | | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 0| 3| 3| 0| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| |
| 7| 5| 6| 6| 1| 4| 7| 7| 7| 6| 4| 6| 5| 7| 6| 4| 7| 6| 6| 8| 6| 6| 5| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation | 1 1 1 | 5 1.0|
Inflammation, Suppurative | 2| 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 1 2 2| 11 1.4|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 2 2 2 1 1 1 1| 16 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 2| 7 1.1|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 1 2.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1| 20 1.1|
Artery, Inflammation, Chronic Active | | 1 3.0|
Renal Tubule, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 9| 3| 1| 3| 3| 0| 3| 3| 0| 3| 9| 3| 3| 3| 2| 3| 3| 3| 3|
| 5| 7| 6| 7| 6| 1| 2| 6| 4| 5| 5| 8| 6| 5| 8| 7| 8| 5| 5| 7| 8| 5| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
62.5 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + A + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + A + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Necrosis | |
Tension Lipidosis | X|
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Thrombosis | 3 |
Fat, Necrosis | 2 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy | |
Basophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
Infiltration Cellular, Mast Cell | 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M M M + + M M M M + M M M M A + M M M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Pars Distalis, Hyperplasia | 4 1 4 4 3 3 1 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 9| 3| 1| 3| 3| 0| 3| 3| 0| 3| 9| 3| 3| 3| 2| 3| 3| 3| 3|
| 5| 7| 6| 7| 6| 1| 2| 6| 4| 5| 5| 8| 6| 5| 8| 7| 8| 5| 5| 7| 8| 5| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
62.5 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 4 1 1 2 4 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + M + + + + A + + + M + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + A + I + + + + + +|
Angiectasis | |
Cyst | 3 3 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +|
Angiectasis | |
Hydrometra | 4 2 3 3 |
Infiltration Cellular, Mast Cell | 3 |
Infiltration Cellular, | |
Polymorphonuclear | |
Necrosis | 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +|
Infiltration Cellular, Mast Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + + + M + M + + + + + + M A + + M + M M M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + M M + M + + + + + + A + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + + + + + + + + + M + + M A M + M + + M + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 3 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + M + + + + + A + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 9| 3| 1| 3| 3| 0| 3| 3| 0| 3| 9| 3| 3| 3| 2| 3| 3| 3| 3|
| 5| 7| 6| 7| 6| 1| 2| 6| 4| 5| 5| 8| 6| 5| 8| 7| 8| 5| 5| 7| 8| 5| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
62.5 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + A + + + + + + + +|
Epiglottis, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation | 1 2 1 1 1 |
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 1 1 1 1 1 1 2 1 2 1 1 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 1 1 |
Turbinate, Necrosis | 2 2 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Infarct | |
Nephropathy | 1 1 1 4 2 1 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Infiltration Cellular, Mast Cell | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 3| 3| 6| 3| 3| 3| 1| 3| |
| 7| 6| 6| 7| 6| 6| 5| 7| 5| 6| 7| 6| 7| 6| 5| 7| 2| 6| 7| 3| 7| 5| 5| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
62.5 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + M + M + + + + + + M A + I + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Basophilic Focus | X | 4 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X X X X | 6 |
Necrosis | 1 | 1 1.0|
Tension Lipidosis | | 1 |
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Thrombosis | | 1 3.0|
Fat, Necrosis | 4 | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Atrophy | 4 | 1 4.0|
Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mast Cell | | 1 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | +| 1 |
Developmental Malformation | X| 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 | 2 2.5|
Hypertrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 3| 3| 6| 3| 3| 3| 1| 3| |
| 7| 6| 6| 7| 6| 6| 5| 7| 5| 6| 7| 6| 7| 6| 5| 7| 2| 6| 7| 3| 7| 5| 5| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
62.5 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M M M M + + M M + M M M + M + M M + + M M M| 15 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 3 2 3 3 2 1 2 1 3 3 3 1 3 2 2 2| 24 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 2 2 1 | 24 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + M + M + + M + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
Angiectasis | 4 | 1 4.0|
Cyst | 2 2 2 2 4 2 3 3| 12 2.6|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Angiectasis | 1 | 1 1.0|
Hydrometra | 3 3 3 | 7 3.0|
Infiltration Cellular, Mast Cell | | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
Necrosis | | 1 2.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + + + + + M + + + + + M M + + + M + M + +| 32 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + M + + + + + + + + + M + M +| 40 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + M + + M M M M M M M + M M + M A M M + + M| 23 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 2 2 4 | 8 2.8|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + A + + + M +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 3| 3| 6| 3| 3| 3| 1| 3| |
| 7| 6| 6| 7| 6| 6| 5| 7| 5| 6| 7| 6| 7| 6| 5| 7| 2| 6| 7| 3| 7| 5| 5| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
62.5 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epiglottis, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 3 2 | 4 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 2 | 7 1.3|
Olfactory Epithelium, Atrophy | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2| 10 1.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 1 1 2 1 2 2 1 2 1 1 2 1 1 1 1 1| 35 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 1 1 1 | 11 1.0|
Turbinate, Necrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | 3 1 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 3| 3| 6| 3| 3| 3| 1| 3| |
| 7| 6| 6| 7| 6| 6| 5| 7| 5| 6| 7| 6| 7| 6| 5| 7| 2| 6| 7| 3| 7| 5| 5| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
62.5 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 1 1 | 14 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Infiltration Cellular, Mast Cell | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 1| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 3| 3| 3| 3| 3|
| 6| 6| 5| 3| 9| 6| 0| 0| 6| 6| 5| 5| 5| 5| 7| 5| 6| 4| 2| 6| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + A + + + + + + + + M + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Eosinophilic Focus | X X X |
Fatty Change | 2 2 |
Hyperplasia, Lymphoid | 4 |
Necrosis | 3 |
Tension Lipidosis | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hypertrophy | 2 |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + A + + +|
Hyperplasia, Squamous | 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + A + + +|
Infiltration Cellular, Mixed Cell | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | 1 2 2 2 |
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + I + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M + + M M + + + + + + + + M M + + + M + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Pars Distalis, Hyperplasia | 4 4 3 3 1 2 4 3 3 3|
Pars Intermedia, Hypertrophy | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 1| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 3| 3| 3| 3| 3|
| 6| 6| 5| 3| 9| 6| 0| 0| 6| 6| 5| 5| 5| 5| 7| 5| 6| 4| 2| 6| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 4 1 1 1 1 2 2 2 1 1 2 3 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + M + + + + + + + + M + M + + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + A + + + + +|
Cyst | 3 2 2 3 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + A + + + + +|
Angiectasis | 3 |
Hemorrhage | |
Hydrometra | |
Inflammation, Chronic | 3 |
Myometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + M + + + + + + + + + + A + + M|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + M M + M + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + A + A + + +|
Ectasia | 2 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + + + M + + + + + + + + + + + + + + M M + M|
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + A + + +|
Hematopoietic Cell Proliferation | 3 3 2 3 2 2|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M M + M + + + + + M + + + M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 1| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 3| 3| 3| 3| 3|
| 6| 6| 5| 3| 9| 6| 0| 0| 6| 6| 5| 5| 5| 5| 7| 5| 6| 4| 2| 6| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
125 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Epiglottis, Hyperplasia | 2 |
Epiglottis, Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 2 4 |
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 2 2 1 1 2 2 1 1 1 1 1 2 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 1 1 1 2 2 1 |
Turbinate, Necrosis | 1 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hydronephrosis | 2 |
Infarct | 3 |
Nephropathy | 1 1 3 1 1 3 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + A + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 8| 0| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 0| 8| 3| |
| 7| 7| 7| 5| 7| 2| 5| 4| 7| 6| 2| 6| 6| 6| 6| 7| 6| 5| 7| 6| 7| 6| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
125 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + M + + + + + A + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 5 |
Eosinophilic Focus | X | 4 |
Fatty Change | 2 | 3 2.0|
Hyperplasia, Lymphoid | | 1 4.0|
Necrosis | | 1 3.0|
Tension Lipidosis | X | 1 |
Centrilobular, Necrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Necrosis | 1 | 3 1.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypertrophy | | 1 2.0|
Duct, Cyst | 4 | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Acute | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 4 | 7 2.0|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 8| 0| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 0| 8| 3| |
| 7| 7| 7| 5| 7| 2| 5| 4| 7| 6| 2| 6| 6| 6| 6| 7| 6| 5| 7| 6| 7| 6| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
125 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + M + + M M + + M M + + + + + M M M M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 4 4 2 3 4 3 3 2 2 3 3 3 4| 23 3.0|
Pars Intermedia, Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 1 4 1 4| 30 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 4 2 2 2 1 2 2 2 2 2 4| 18 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hemorrhage | 4 | 1 4.0|
Hydrometra | 4 2 3 | 3 3.0|
Inflammation, Chronic | | 1 3.0|
Myometrium, Hyperplasia | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + + + M M M + M M + M + + + + + M + + +| 37 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M M + + + + + + M M + + M + + + + + + M + + +| 39 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Ectasia | | 1 2.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + M M M + M M M M + + + + + + M M + +| 34 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 | 8 2.4|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + M + + M + + + M + + + + M + +| 39 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 8| 0| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 0| 8| 3| |
| 7| 7| 7| 5| 7| 2| 5| 4| 7| 6| 2| 6| 6| 6| 6| 7| 6| 5| 7| 6| 7| 6| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
125 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
Epiglottis, Hyperplasia | | 1 2.0|
Epiglottis, Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 2 1 1 | 13 1.4|
Olfactory Epithelium, Atrophy | 4 4 | 3 3.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 2 1 1 1 1 1 1 | 15 1.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 2 1 1 2 2 1 1 1 3 1| 32 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 2 1 1 1 1 1 | 16 1.3|
Turbinate, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | | 1 2.0|
Infarct | 2 1 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 8| 0| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 0| 8| 3| |
| 7| 7| 7| 5| 7| 2| 5| 4| 7| 6| 2| 6| 6| 6| 6| 7| 6| 5| 7| 6| 7| 6| 2| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
125 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 1 1 1 1 3 1 1 1 1 | 19 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 0| 3| 8|
| 6| 6| 6| 7| 6| 6| 6| 0| 5| 6| 6| 5| 6| 7| 6| 1| 5| 6| 7| 3| 6| 0| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + I + + + + + + + + + + + + + + + M A M +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Basophilic Focus | |
Necrosis | 2 |
Tension Lipidosis | X |
Centrilobular, Necrosis | 2|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Suppurative | 3 |
Thrombosis | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
Mineralization | 3 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + I + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + M M + + M + + + M M M M + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 4 4 2 2 2 4 2 4 2 3 2 2 1 3 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 1 1 1 2 1 2 2 2 1 1 1 2 1 3 2 1 2 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 0| 3| 8|
| 6| 6| 6| 7| 6| 6| 6| 0| 5| 6| 6| 5| 6| 7| 6| 1| 5| 6| 7| 3| 6| 0| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + M M + + + + + + + + + + + + + M M + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 4 2 2 3 2 2 2 |
Inflammation, Suppurative | 4 |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 3 3 |
Infiltration Cellular, | |
Polymorphonuclear | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M M + M + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M M + + + + + + + I M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M M + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + + + + M M + + + + + + + + + M + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Hematopoietic Cell Proliferation | 4 4 3 4 3 4|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 0| 3| 8|
| 6| 6| 6| 7| 6| 6| 6| 0| 5| 6| 6| 5| 6| 7| 6| 1| 5| 6| 7| 3| 6| 0| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 2 1 2|
Thrombosis | 2|
Olfactory Epithelium, Atrophy | 2 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 1 1 1 1 1 1 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 1 2 1 1 2 2|
Turbinate, Necrosis | 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Infarct | 2 |
Metaplasia, Osseous | 1 2 |
Nephropathy | 1 1 1 1 1 3 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + I + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 5| 3| 1| 8| 2| 3| 3| 3| 3| 9| 8| 3| 3| 4| 3| 3| 3| 0| 3| 3| 3| 3| |
| 5| 2| 3| 2| 6| 2| 5| 3| 7| 1| 5| 6| 2| 6| 5| 6| 2| 7| 7| 7| 7| 7| 6| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A A M + A + M + + + + + + + + + + + + +| 41 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + I A + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A A + + A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A + + A + + + + + + + + + + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A A + + A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 3.0|
Basophilic Focus | X X | 2 |
Necrosis | 2 | 2 2.0|
Tension Lipidosis | | 1 |
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 6 |
Inflammation, Suppurative | | 1 3.0|
Thrombosis | 2 | 1 2.0|
Fat, Necrosis | 2 2 2| 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 5| 3| 1| 8| 2| 3| 3| 3| 3| 9| 8| 3| 3| 4| 3| 3| 3| 0| 3| 3| 3| 3| |
| 5| 2| 3| 2| 6| 2| 5| 3| 7| 1| 5| 6| 2| 6| 5| 6| 2| 7| 7| 7| 7| 7| 6| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + M + M M + M + + M + + + + M M + + M +| 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 3 3 3 2 3 4 3 2 3 3 3 2 | 28 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 37 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2| 1 2.0|
Cyst | 2 2 4 2 2 3 1 1 3 2 1 | 18 2.2|
Inflammation, Suppurative | | 1 4.0|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hydrometra | 4 3 | 5 3.4|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Lumbar, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M M + + + A + M M + + + + + + M + M + M M| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + M + + + + M + + M + + + M + + + M + M| 38 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + I + + +| 46 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + M + + + M + M M + + + + M M + M + M + +| 37 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 3 3 4 3| 12 3.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + A + + + + + + M + + + + + M + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 5| 3| 1| 8| 2| 3| 3| 3| 3| 9| 8| 3| 3| 4| 3| 3| 3| 0| 3| 3| 3| 3| |
| 5| 2| 3| 2| 6| 2| 5| 3| 7| 1| 5| 6| 2| 6| 5| 6| 2| 7| 7| 7| 7| 7| 6| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + + I| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 1 1 4 1 | 14 1.4|
Thrombosis | | 1 2.0|
Olfactory Epithelium, Atrophy | 2 | 3 1.7|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1| 10 1.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1| 30 1.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 3 1 2 1 2 2 1 1 1 2 | 21 1.5|
Turbinate, Necrosis | 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 2.0|
Infarct | 2 | 2 2.0|
Metaplasia, Osseous | | 2 1.5|
Nephropathy | 1 1 2 1 1 1 1 2| 16 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 6| 7| 5| 6| 5| 6| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 9| 3| 3| 2| 3| 7| 8| 3| 1| 1| 3| 0| 2| 3| 0| 3| 7| 3|
| 5| 3| 4| 4| 4| 5| 5| 8| 5| 3| 6| 3| 3| 8| 4| 6| 6| 5| 2| 3| 4| 2| 2| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + A + M A + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + A + I + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + A + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + A + + A + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + A + + A + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + A + + A + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Diffuse | |
Basophilic Focus | X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X |
Mixed Cell Focus | X X |
Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Artery, Mineralization | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Hyperplasia, Squamous | 4 |
Inflammation, Acute | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + |
Developmental Malformation | X X X X X X |
Inflammation, Chronic Active | 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Artery, Inflammation | |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 |
Hypertrophy | 2 2 1 2 2 2 1 3 2 2 2 1 2|
Necrosis | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 6| 7| 5| 6| 5| 6| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 9| 3| 3| 2| 3| 7| 8| 3| 1| 1| 3| 0| 2| 3| 0| 3| 7| 3|
| 5| 3| 4| 4| 4| 5| 5| 8| 5| 3| 6| 3| 3| 8| 4| 6| 6| 5| 2| 3| 4| 2| 2| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 |
Necrosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + M + A + M + M M M M + M + + M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + I + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + A + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + A + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + A + + M + + + M + + + M M + + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + A + + + M + + + M + M M M M + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M + + A + M M M + M + + + + M M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 2 3 2 2 3 3 |
__________________________________________________________________________|
Thymus | + + M + + + + A + + + + + + + + + + M + M + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + A + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 3 4 3 4 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 6| 7| 5| 6| 5| 6| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 9| 3| 3| 2| 3| 7| 8| 3| 1| 1| 3| 0| 2| 3| 0| 3| 7| 3|
| 5| 3| 4| 4| 4| 5| 5| 8| 5| 3| 6| 3| 3| 8| 4| 6| 6| 5| 2| 3| 4| 2| 2| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + A + + + + + + + + + + + + + + + + +|
Glands, Inflammation | 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + A + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mediastinum, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 1 1 |
Polyp, Inflammatory | 3 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 2 |
Inflammation | 1 |
Mineralization | 2 |
Nephropathy | 1 1 2 1 2 2 2 2 1 1 1 3 1 1 2 3 2 1 1 1 1|
Glomerulus, Inflammation, Suppurative| 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 5| 3| 3| 1| 3| 7| 1| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| |
| 3| 4| 3| 3| 3| 4| 9| 3| 3| 2| 4| 0| 6| 3| 5| 3| 5| 4| 3| 4| 3| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + A + + + + + A + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + A + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + A + + + + I + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + A + + + + + A + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + A + + + + + A + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + A + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Atypia Cellular, Diffuse | 4 | 1 4.0|
Basophilic Focus | X | 5 |
Clear Cell Focus | X X X X X| 9 |
Eosinophilic Focus | X X X X X| 7 |
Mixed Cell Focus | | 2 |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Artery, Mineralization | 3 | 1 3.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + A + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Diverticulum | | 1 |
Hyperplasia, Squamous | 1 | 2 2.5|
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + A + + + + + + +| 46 |
__________________________________________________________________________|____________|
Tooth | + + + + + + | 13 |
Developmental Malformation | X X X X X X | 12 |
Inflammation, Chronic Active | | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
Artery, Inflammation | 3 | 1 3.0|
Artery, Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 5| 3| 3| 1| 3| 7| 1| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| |
| 3| 4| 3| 3| 3| 4| 9| 3| 3| 2| 4| 0| 6| 3| 5| 3| 5| 4| 3| 4| 3| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + A + + + + + A + + + + + + +| 47 |
Hyperplasia | 2 1 2 2 2 2| 10 1.8|
Hypertrophy | 2 1 2 2 3 2 2 2 1 2 2 2 3 2 2 2 2 2 2| 32 1.9|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + A + + + + + A + + + + + + +| 47 |
Hyperplasia | 3 | 2 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + A + + + + + + +| 47 |
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M M + M M M + A + + M M M M + M + + M + +| 21 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + I A I + + + + + + + + + + + +| 46 |
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 1 2 1 1 1 1 1| 14 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Granuloma Sperm | | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 3 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + A + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + M M M + + M + M + M + + + M M + + +| 34 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + M + + M M + + M + M + + + + + + + + M +| 36 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + A + + + + + M + + + + + + +| 46 |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + + + M M + M + M + + M M M + M M + M + +| 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 5| 3| 3| 1| 3| 7| 1| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| |
| 3| 4| 3| 3| 3| 4| 9| 3| 3| 2| 4| 0| 6| 3| 5| 3| 5| 4| 3| 4| 3| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 3 3 2 | 12 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + A + M + M + A + + + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Prepuce, Inflammation, Chronic Active| 2 1 | 7 2.9|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + A + + + + + A + + + + + + +| 47 |
Glands, Inflammation | | 5 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Alveolar Epithelium, Hyperplasia | 1 2 | 3 1.3|
Artery, Mediastinum, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Inflammation | 1 1 | 6 1.2|
Polyp, Inflammatory | | 1 3.0|
Olfactory Epithelium, Atrophy | 3 | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 1 1.0|
Olfactory Epithelium, Metaplasia | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 | 5 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 5| 3| 3| 1| 3| 7| 1| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| |
| 3| 4| 3| 3| 3| 4| 9| 3| 3| 2| 4| 0| 6| 3| 5| 3| 5| 4| 3| 4| 3| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Hydronephrosis | | 2 2.5|
Inflammation | | 1 1.0|
Mineralization | | 1 2.0|
Nephropathy | 1 1 2 2 1 1 2 2 3 1 2 1 2 2 1 1 1 2 1 2 2 2 2| 44 1.6|
Glomerulus, Inflammation, Suppurative| | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + A + + + + + A + + + + + + +| 47 |
Inflammation, Chronic Active | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 3| 7| 7| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 8| 0| 1| 0| 6| 7| 3| 3| 9| 3| 3| 3| 0| 3| 8| 6| 3| 3| 3| 4| 4| 4| 3| 3|
| 4| 5| 6| 8| 2| 6| 3| 4| 5| 8| 3| 3| 3| 7| 5| 8| 4| 3| 3| 9| 0| 0| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
62.5 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + A + M M M + A + M M A A A A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + A + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + A + + + + + A + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + A + + + + + A + + + A + A A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + A + + + + + A + + + A A A A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + A A A A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + A + A A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Mixed Cell Focus | X X |
Necrosis | |
Tension Lipidosis | X |
Centrilobular, Necrosis | 3 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + A + + + + + A + + +|
Infiltration Cellular, Mixed Cell | 3 |
Necrosis | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + |
Developmental Malformation | X X X X X X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia | 1 2 2 |
Hypertrophy | 2 2 2 1 2 1 2 2 1 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + M + + M + M M + M M + + M + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + A + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 3| 7| 7| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 8| 0| 1| 0| 6| 7| 3| 3| 9| 3| 3| 3| 0| 3| 8| 6| 3| 3| 3| 4| 4| 4| 3| 3|
| 4| 5| 6| 8| 2| 6| 3| 4| 5| 8| 3| 3| 3| 7| 5| 8| 4| 3| 3| 9| 0| 0| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
62.5 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Follicular Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + I + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + M + M M M M M M M + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + M A M + + + + + M M M + + M + + M + M A + I M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + M + + M + A + M + + + A + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M M M + + M M M + + M + + + M M + + M + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + A + + +|
Hematopoietic Cell Proliferation | 3 2 4 3 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + M M A + + + + + M M + M M M + + + + + M A + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Demyelination, Focal | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 3| 7| 7| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 8| 0| 1| 0| 6| 7| 3| 3| 9| 3| 3| 3| 0| 3| 8| 6| 3| 3| 3| 4| 4| 4| 3| 3|
| 4| 5| 6| 8| 2| 6| 3| 4| 5| 8| 3| 3| 3| 7| 5| 8| 4| 3| 3| 9| 0| 0| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
62.5 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Inflammation | 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1|
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1|
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
Cyst | 1 3 2|
Hydronephrosis | 2 2 |
Metaplasia, Osseous | 1|
Nephropathy | 2 2 1 2 2 2 2 2 1 4 2 1 1 1 2 3 1 2 1|
Glomerulus, Inflammation, Suppurative| 3 |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + A + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 5| 7| |
DAY ON TEST | 1| 5| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 7| 9| 2| |
| 6| 1| 4| 4| 3| 4| 5| 4| 4| 3| 4| 4| 4| 5| 3| 4| 4| 7| 0| 3| 4| 4| 6| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
62.5 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + M + + + + + + + + + + + + + + + + +| 36 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X | 8 |
Clear Cell Focus | X X X X | 6 |
Eosinophilic Focus | X X X | 6 |
Mixed Cell Focus | | 2 |
Necrosis | 2 | 1 2.0|
Tension Lipidosis | | 1 |
Centrilobular, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Mixed Cell | 3 | 2 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + | 17 |
Developmental Malformation | X X X X X X X X X | 17 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Artery, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2 | 9 1.9|
Hypertrophy | 2 2 2 2 2 2 1 2 2 2 2 1 2| 26 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 5| 7| |
DAY ON TEST | 1| 5| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 7| 9| 2| |
| 6| 1| 4| 4| 3| 4| 5| 4| 4| 3| 4| 4| 4| 5| 3| 4| 4| 7| 0| 3| 4| 4| 6| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
62.5 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2| 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + M M + + M + + + M M + M + M + M M + M +| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 2 1 1 1| 9 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + M M + + + + + + M + + + M + M M + + M + M| 28 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M M + + + M M M M M + + M + M M M + M M + M| 22 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M M M M M + + M + + + M + + M M + + + + I| 27 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 2 3 3 3| 14 2.9|
Hyperplasia, Lymphoid | 4 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | M + + + M + + M + + + + M + + + + + + + + + M + M| 34 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Chronic Active| 4 3 4 3 4 4 | 7 3.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 5| 7| |
DAY ON TEST | 1| 5| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 7| 9| 2| |
| 6| 1| 4| 4| 3| 4| 5| 4| 4| 3| 4| 4| 4| 5| 3| 4| 4| 7| 0| 3| 4| 4| 6| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
62.5 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Demyelination, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Glands, Inflammation | 2 | 3 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 3 2 | 3 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 | 4 1.0|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 1 2.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 | 3 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 4 2.0|
Hydronephrosis | 3 | 3 2.3|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 2 1 2 1 2 2 1 1 2 1 2 2 1 1 2 2 1 3 1 2 1 2 2| 43 1.7|
Glomerulus, Inflammation, Suppurative| | 1 3.0|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 4| 3| 4| 3| 4| 4| 6| 4| 0| 3| 4| 9| 4| 4| 5| 5| 4| 3| 3| 5| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + A + + + + + + M + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + I + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Metaplasia, Hepatocyte | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Hepatocyte | 3 |
__________________________________________________________________________|
Tooth | + + + + + + +|
Developmental Malformation | X X X X X X X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Artery, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 2 2 2 |
Hypertrophy | 1 2 2 2 2 1 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + + + + M + + M + M + I M M M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 4| 3| 4| 3| 4| 4| 6| 4| 0| 3| 4| 9| 4| 4| 5| 5| 4| 3| 3| 5| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + M M + + M M + + M + M + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + M + + + + M + + M + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + M + + + + + + + + + + M + + + + + + +|
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M M M + + + + + + M + + M M + + M + + + + M|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 3 3 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + M M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 4| 3| 4| 3| 4| 4| 6| 4| 0| 3| 4| 9| 4| 4| 5| 5| 4| 3| 3| 5| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Inflammation | 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 1 |
Turbinate, Necrosis | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Acute | 3 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydronephrosis | 2 |
Metaplasia, Osseous | 2 1 |
Nephropathy | 1 2 3 1 2 1 1 2 1 2 1 1 1 2 1 1 2 1 2 2 1 1 1|
Thrombosis | |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 0| 1| 3| 3| 3| 3| |
| 3| 2| 3| 4| 3| 4| 3| 5| 3| 3| 4| 4| 9| 3| 4| 5| 4| 3| 4| 2| 9| 3| 5| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
125 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + M + + A + + M + M + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 4 |
Clear Cell Focus | X X X X X X | 9 |
Eosinophilic Focus | X X | 5 |
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + +| 3 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
Metaplasia, Hepatocyte | 2 | 1 2.0|
Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Hepatocyte | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + | 10 |
Developmental Malformation | X X X | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Artery, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 1 2 3 2| 18 1.9|
Hypertrophy | 2 2 2 2 1 2 2 1 2 1 2 2 2 2 2 2 1| 31 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 0| 1| 3| 3| 3| 3| |
| 3| 2| 3| 4| 3| 4| 3| 5| 3| 3| 4| 4| 9| 3| 4| 5| 4| 3| 4| 2| 9| 3| 5| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
125 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + M M + + + M M M M M + M + M M + I| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + I + + + + + + M + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 1 2 | 11 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + M + M + + + M + + + + + + M M + + M +| 35 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + M M M M M M + + M + M M M + M + + + + M| 30 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M + + M + + M + + + + + + + + + M M + + + +| 33 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 4 3 3 | 12 3.1|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + M + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 0| 1| 3| 3| 3| 3| |
| 3| 2| 3| 4| 3| 4| 3| 5| 3| 3| 4| 4| 9| 3| 4| 5| 4| 3| 4| 2| 9| 3| 5| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
125 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Prepuce, Inflammation, Chronic Active| 4 4 4 | 4 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Inflammation | 1 | 3 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 1 1 | 5 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 3 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 | 5 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 | 6 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 | 6 1.2|
Turbinate, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 2 2.0|
Hydronephrosis | 3 | 2 2.5|
Metaplasia, Osseous | | 2 1.5|
Nephropathy | 1 2 2 1 2 2 1 2 2 2 2 4 2 2 2 1 2 2 1 2 2 2 1| 46 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 0| 1| 3| 3| 3| 3| |
| 3| 2| 3| 4| 3| 4| 3| 5| 3| 3| 4| 4| 9| 3| 4| 5| 4| 3| 4| 2| 9| 3| 5| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
125 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Thrombosis | 2 | 1 2.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, | | |
Polymorphonuclear | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 6|
| 3| 4| 4| 4| 1| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 5| 4| 3| 3| 4| 3| 4| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X |
Fatty Change | 1 1 |
Necrosis | 4 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | |
Basophilic Focus | X |
Metaplasia, Hepatocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Necrosis | 1|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
Developmental Malformation | X X X X X X X X X X X X |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 2 |
Hypertrophy | 2 2 2 2 2 2 2 2 3 1 3 1 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 2 1 2 3 3 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + M M + + M + + + M + M M M + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Pars Distalis, Hyperplasia | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 6|
| 3| 4| 4| 4| 1| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 5| 4| 3| 3| 4| 3| 4| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Follicular Cell, | |
Hyperplasia | |
Follicular Cell, Hyperplasia | 2 1 2 1 1 1 1 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + I + + + + + + + + + I + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + M + + + + M + + + + + + M M + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + + M + + M + + + M M + + M + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M + + + + M M M M M M + M + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hematopoietic Cell Proliferation | 4 4|
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + + + + + + + + + + M|
Hyperplasia, Tubular | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + I + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 6|
| 3| 4| 4| 4| 1| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 5| 4| 3| 3| 4| 3| 4| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 |
Nasolacrimal Duct, Inflammation | 2 |
Olfactory Epithelium, Atrophy | 2 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 1 |
__________________________________________________________________________|
Pleura | + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy | 2 2 3 2 2 2 2 1 1 1 2 2 2 1 1 2 2 2 1 1 2 2 2 1|
Papilla, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 4| 2| 3| 8| 3| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 4| 4| 1| 8| 3| 9| 4| 4| 3| 4| 3| 3| 4| 5| 2| 4| 3| 4| 4| 4| 3| 4| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + A A + A + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X| 6 |
Clear Cell Focus | X X X | 7 |
Eosinophilic Focus | | 3 |
Fatty Change | | 2 1.0|
Necrosis | | 2 2.5|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Necrosis | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 1 | 1 1.0|
Basophilic Focus | | 1 |
Metaplasia, Hepatocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + | 19 |
Developmental Malformation | X X X X X X X | 19 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2| 12 1.9|
Hypertrophy | 2 2 2 2 2 1 2 2 2 2 1 1 2 2 2 2 2 2 2| 34 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 4| 2| 3| 8| 3| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 4| 4| 1| 8| 3| 9| 4| 4| 3| 4| 3| 3| 4| 5| 2| 4| 3| 4| 4| 4| 3| 4| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 6 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M A M + + + M + M M + + M + M M M M M + M +| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + A + + I + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 3 1 | 4 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Follicular Cell, | | |
Hyperplasia | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 1 1 1 2 2 2 3| 18 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + A + + + + + + + + + + + + + + M + + M + +| 47 |
__________________________________________________________________________|____________|
Prostate | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + M + + + + + + + + + + + M + + M M + +| 37 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + A M + M + M M + M M + M + + + + + + M + +| 33 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + I + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M A + + M + + + + + M + + M + M + M + + + +| 30 |
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 3 2 3 3 | 7 3.1|
__________________________________________________________________________|____________|
Thymus | + + + M A M + + + + + + + + + + + + + + + + + + +| 44 |
Hyperplasia, Tubular | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Prepuce, Inflammation, Chronic Active| 1 4 4 3 | 5 3.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:40:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 4| 2| 3| 8| 3| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 4| 4| 1| 8| 3| 9| 4| 4| 3| 4| 3| 3| 4| 5| 2| 4| 3| 4| 4| 4| 3| 4| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Inflammation | 1 1| 3 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 1 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 5 1.0|
Nasolacrimal Duct, Inflammation | | 1 2.0|
Olfactory Epithelium, Atrophy | | 2 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 | 2 1.0|
Olfactory Epithelium, Metaplasia | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1| 10 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 1 1 1 | 9 1.1|
__________________________________________________________________________|____________|
Pleura | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | | 1 2.0|
Nephropathy | 2 1 1 1 1 2 2 2 2 2 2 2 2 2 3 3 1 1 2 3 3 2 1| 47 1.8|
Papilla, Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + A + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------