https://ntp.niehs.nih.gov/go/4524

TDMS Study 05184-06 Pathology Tables


NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 07/13/98       
EXPERIMENT: 05184 TEST: 06                                                                                     TIME: 08:41:09       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-30-8        
------------------------------------------------------------------------------------------------------------------------------------
                                                             CORE STUDY                                                             
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 07/13/98     
EXPERIMENT: 05184 TEST: 06                                                                                     TIME: 08:41:09     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-30-8      
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  GLUTARALDEHYDE
===============================================================
Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Kidney                                 Cyst
Kidney: Papilla                        Inflammation
Liver                                  Eosinophilic Focus
                                       Fatty Change
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Metaplasia
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Liver                                  Eosinophilic Focus
Lung: Alveolar Epithelium              Hyperplasia
Lymph Node, Mesenteric                 Hyperplasia Lymphoid
Nose                                   Inflammation
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Metaplasia
Pituitary Gland: Pars Distalis         Hyperplasia
Spleen                                 Hyperplasia Lymphoid
Thyroid Gland: Follicular Cell         Hyperplasia
===============================================================
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/47 (21%)  9/49 (18%)   18/50 (36%)  12/49 (24%) |2/50 (4%)    2/49 (4%)    7/49 (14%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     23.7%        22.5%        40.0%        26.0%       |4.4%         4.4%         15.3%        2.3%         |
|TERMINAL (d)       |     8/31 (26%)   7/27 (26%)   17/40 (43%)  8/38 (21%)  |1/34 (3%)    1/37 (3%)    6/35 (17%)   0/32 (0%)    |
|FIRST INCIDENCE    |     359          588          715          558         |616          706          502          723          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.525      P=0.585      P=0.198      P=0.575     |P=0.535N     P=0.663N     P=0.091      P=0.512N     |
|POLY 3             |     P=0.382      P=0.553N     P=0.079      P=0.501     |P=0.529N     P=0.692N     P=0.083      P=0.511N     |
|POLY 1.5           |     P=0.333      P=0.518N     P=0.077      P=0.476     |P=0.515N     P=0.692      P=0.081      P=0.505N     |
|POLY 6             |     P=0.450      P=0.588N     P=0.089      P=0.538     |P=0.546N     P=0.687N     P=0.084      P=0.516N     |
|LOGISTIC REGRESSION|     P=0.353      P=0.509N     P=0.097      P=0.436     |P=0.497N     P=0.684      P=0.069      P=0.499N     |
|COCH-ARM / FISHERS |     P=0.276      P=0.459N     P=0.084      P=0.448     |P=0.498N     P=0.684      P=0.075      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/47 (68%)  26/49 (53%)  31/50 (62%)  34/49 (69%) |2/50 (4%)    2/49 (4%)    1/49 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     76.6%        62.6%        66.6%        75.0%       |4.5%         4.4%         2.2%         4.6%         |
|TERMINAL (d)       |     27/31 (87%)  20/27 (74%)  27/40 (68%)  31/38 (82%) |1/34 (3%)    2/37 (5%)    1/35 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     602          402          470          641         |708          735 (T)      735 (T)      723          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.201N     P=0.388N     P=0.055N     P=0.205N    |P=0.602      P=0.659N     P=0.487N     P=0.681      |
|POLY 3             |     P=0.446      P=0.107N     P=0.204N     P=0.532N    |P=0.582N     P=0.691N     P=0.497N     P=0.686      |
|POLY 1.5           |     P=0.374      P=0.099N     P=0.263N     P=0.580N    |P=0.578N     P=0.693      P=0.499N     P=0.690      |
|POLY 6             |     P=0.535      P=0.132N     P=0.140N     P=0.479N    |P=0.586N     P=0.685N     P=0.494N     P=0.682      |
|LOGISTIC REGRESSION|     P=0.515N     P=0.217N     P=0.237N     P=0.368N    |P=0.599N     P=0.681N     P=0.492N     P=0.684      |
|COCH-ARM / FISHERS |     P=0.294      P=0.097N     P=0.340N     P=0.533     |P=0.575N     P=0.684      P=0.508N     P=0.691N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/47 (4%)    2/49 (4%)    2/50 (4%)    2/49 (4%)   |3/50 (6%)    1/49 (2%)    5/48 (10%)   1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     4.9%         5.1%         4.4%         4.5%        |6.7%         2.2%         11.1%        2.3%         |
|TERMINAL (d)       |     2/31 (7%)    0/27 (0%)    2/40 (5%)    2/38 (5%)   |3/34 (9%)    0/37 (0%)    4/35 (11%)   0/31 (0%)    |
|FIRST INCIDENCE    |     733 (T)      707          733 (T)      733 (T)     |735 (T)      706          502          660          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.482N     P=0.644      P=0.600N     P=0.620N    |P=0.411N     P=0.269N     P=0.372      P=0.334N     |
|POLY 3             |     P=0.550N     P=0.682      P=0.659N     P=0.660N    |P=0.399N     P=0.300N     P=0.360      P=0.319N     |
|POLY 1.5           |     P=0.563N     P=0.692      P=0.666N     P=0.668N    |P=0.390N     P=0.305N     P=0.352      P=0.316N     |
|POLY 6             |     P=0.535N     P=0.670      P=0.647N     P=0.650N    |P=0.408N     P=0.293N     P=0.368      P=0.321N     |
|LOGISTIC REGRESSION|     P=0.513N     P=0.662      P=0.600N     P=0.620N    |P=0.379N     P=0.290N     P=0.334      P=0.321N     |
|COCH-ARM / FISHERS |     P=0.582N     P=0.676N     P=0.668N     P=0.676N    |P=0.380N     P=0.316N     P=0.335      P=0.316N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    0/50 (0%)    0/50 (0%)    1/49 (2%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.7%         0.0%         0.0%         2.2%        |                                                    |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |                                                    |
|FIRST INCIDENCE    |     573          ---          ---          672         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.418N     P=0.263N     P=0.212N     P=0.460N    |                                                    |
|POLY 3             |     P=0.440N     P=0.249N     P=0.223N     P=0.477N    |                                                    |
|POLY 1.5           |     P=0.447N     P=0.241N     P=0.226N     P=0.483N    |                                                    |
|POLY 6             |     P=0.431N     P=0.260N     P=0.217N     P=0.468N    |                                                    |
|LOGISTIC REGRESSION|     P=0.477N     P=0.212N     P=0.229N     P=0.518N    |                                                    |
|COCH-ARM / FISHERS |     P=0.458N     P=0.237N     P=0.237N     P=0.492N    |                                                    |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |704          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.214N     P=0.231N     P=0.246N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.235N     P=0.231N     P=0.243N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.238N     P=0.233N     P=0.240N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.232N     P=0.231N     P=0.246N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.115N     P=0.235N     P=0.231N     P=0.243N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.253N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/47 (6%)    2/48 (4%)    1/50 (2%)    6/48 (13%)  |1/50 (2%)    0/48 (0%)    2/49 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     7.3%         5.2%         2.2%         13.2%       |2.2%         0.0%         4.4%         2.3%         |
|TERMINAL (d)       |     2/31 (7%)    1/27 (4%)    0/40 (0%)    5/38 (13%)  |1/34 (3%)    0/37 (0%)    1/35 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     688          706          470          558         |735 (T)      ---          524          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188      P=0.556N     P=0.248N     P=0.339     |P=0.479      P=0.483N     P=0.509      P=0.748      |
|POLY 3             |     P=0.143      P=0.530N     P=0.267N     P=0.294     |P=0.480      P=0.499N     P=0.509      P=0.753      |
|POLY 1.5           |     P=0.132      P=0.514N     P=0.275N     P=0.278     |P=0.487      P=0.502N     P=0.504      P=0.754      |
|POLY 6             |     P=0.154      P=0.547N     P=0.256N     P=0.309     |P=0.472      P=0.494N     P=0.514      P=0.751      |
|LOGISTIC REGRESSION|     P=0.114      P=0.546N     P=0.285N     P=0.266     |P=0.502      (e)          P=0.448      P=0.748      |
|COCH-ARM / FISHERS |     P=0.117      P=0.490N     P=0.285N     P=0.254     |P=0.497      P=0.510N     P=0.492      P=0.747      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    4/49 (8%)    2/50 (4%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         10.2%        4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    3/27 (11%)   2/40 (5%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          707          733 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.254N     P=0.048 *    P=0.296      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.308N     P=0.053      P=0.254      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.316N     P=0.057      P=0.250      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.297N     P=0.049 *    P=0.263      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.277N     P=0.048 *    P=0.296      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.330N     P=0.061      P=0.258      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    3/49 (6%)    2/50 (4%)    1/49 (2%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.7%         7.3%         4.4%         2.2%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     616          402          702          327         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.275N     P=0.474      P=0.630N     P=0.474N    |P=0.686      (e)          P=0.506      (e)          |
|POLY 3             |     P=0.279N     P=0.490      P=0.670N     P=0.471N    |P=0.679      (e)          P=0.502      (e)          |
|POLY 1.5           |     P=0.289N     P=0.498      P=0.675N     P=0.479N    |P=0.685      (e)          P=0.501      (e)          |
|POLY 6             |     P=0.269N     P=0.480      P=0.660N     P=0.464N    |P=0.674      (e)          P=0.504      (e)          |
|LOGISTIC REGRESSION|     P=0.384N     P=0.642      P=0.682N     P=0.562N    |(e)          (e)          P=0.506      (e)          |
|COCH-ARM / FISHERS |     P=0.305N     P=0.510      P=0.676N     P=0.492N    |P=0.692      (e)          P=0.495      (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    2/49 (4%)    3/49 (6%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.2%         4.4%         6.6%         4.6%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    2/37 (5%)    2/35 (6%)    2/32 (6%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |664          735 (T)      570          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.370      P=0.525      P=0.321      P=0.480      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.382      P=0.502      P=0.312      P=0.485      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.389      P=0.499      P=0.308      P=0.489      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.374      P=0.507      P=0.315      P=0.481      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.396      P=0.498      P=0.264      P=0.489      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.397      P=0.492      P=0.301      P=0.492      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Metaplasia Osseous                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    1/49 (2%)    2/50 (4%)    0/49 (0%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         4.4%         0.0%        |2.2%         0.0%         0.0%         4.6%         |
|TERMINAL (d)       |     0/31 (0%)    1/27 (4%)    2/40 (5%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |704          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.545N     P=0.472      P=0.296      (e)         |P=0.227      P=0.470N     P=0.489N     P=0.486      |
|POLY 3             |     P=0.586N     P=0.488      P=0.254      (e)         |P=0.238      P=0.498N     P=0.498N     P=0.486      |
|POLY 1.5           |     P=0.597N     P=0.495      P=0.250      (e)         |P=0.240      P=0.500N     P=0.500N     P=0.490      |
|POLY 6             |     P=0.574N     P=0.481      P=0.263      (e)         |P=0.235      P=0.495N     P=0.497N     P=0.483      |
|LOGISTIC REGRESSION|     (e)          P=0.472      P=0.296      (e)         |P=0.233      P=0.504N     P=0.505N     P=0.485      |
|COCH-ARM / FISHERS |     P=0.612N     P=0.505      P=0.258      (e)         |P=0.243      P=0.505N     P=0.505N     P=0.492      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     44/48 (92%)  43/49 (88%)  46/50 (92%)  47/49 (96%) |20/50 (40%)  14/49 (29%)  19/49 (39%)  16/49 (33%)  |
|POLY-3 ADJUSTED (b)|     96.5%        91.8%        96.6%        98.0%       |43.7%        30.4%        39.6%        35.9%        |
|TERMINAL (d)       |     31/31 (100%) 27/27 (100%) 40/40 (100%) 38/38 (100%)|16/34 (47%)  10/37 (27%)  12/35 (34%)  10/32 (31%)  |
|FIRST INCIDENCE    |     516          364          470          504         |558          551          502          542          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.064N     P=0.276      P=0.056N     P=0.195N    |P=0.460N     P=0.099N     P=0.453N     P=0.339N     |
|POLY 3             |     P=0.251      P=0.275N     P=0.745      P=0.590     |P=0.388N     P=0.134N     P=0.423N     P=0.295N     |
|POLY 1.5           |     P=0.194      P=0.307N     P=0.676      P=0.441     |P=0.381N     P=0.143N     P=0.461N     P=0.291N     |
|POLY 6             |     P=0.378      P=0.272N     P=0.792N     P=0.791     |P=0.394N     P=0.121N     P=0.383N     P=0.296N     |
|LOGISTIC REGRESSION|     P=0.313      P=0.557N     P=0.644      P=0.508     |P=0.380N     P=0.139N     P=0.540N     P=0.305N     |
|COCH-ARM / FISHERS |     P=0.180      P=0.383N     P=0.619      P=0.329     |P=0.376N     P=0.162N     P=0.532N     P=0.291N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Papilla                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          327         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.052      (e)          (e)          P=0.261     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.049 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.055      (e)          (e)          P=0.269     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.021 *    (e)          (e)          P=0.173     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Glands                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/47 (11%)   3/49 (6%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     11.9%        7.6%         6.7%         6.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/31 (7%)    3/27 (11%)   3/40 (8%)    2/38 (5%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     602          733 (T)      733 (T)      558         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.214N     P=0.429N     P=0.272N     P=0.285N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.258N     P=0.394N     P=0.320N     P=0.307N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.271N     P=0.369N     P=0.323N     P=0.313N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.245N     P=0.427N     P=0.313N     P=0.304N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.282N     P=0.347N     P=0.324N     P=0.352N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.291N     P=0.334N     P=0.323N     P=0.323N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   8/50 (16%)   4/50 (8%)    6/49 (12%)  |2/50 (4%)    4/48 (8%)    5/50 (10%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     11.8%        19.3%        8.9%         13.4%       |4.5%         8.9%         10.9%        4.6%         |
|TERMINAL (d)       |     4/31 (13%)   5/27 (19%)   4/40 (10%)   6/38 (16%)  |1/34 (3%)    3/37 (8%)    4/35 (11%)   1/32 (3%)    |
|FIRST INCIDENCE    |     626          402          733 (T)      733 (T)     |701          714          719          707          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.361N     P=0.212      P=0.358N     P=0.619N    |P=0.558N     P=0.381      P=0.233      P=0.682      |
|POLY 3             |     P=0.498N     P=0.260      P=0.462N     P=0.541     |P=0.533N     P=0.339      P=0.227      P=0.686      |
|POLY 1.5           |     P=0.519N     P=0.273      P=0.475N     P=0.524     |P=0.523N     P=0.332      P=0.225      P=0.690      |
|POLY 6             |     P=0.474N     P=0.245      P=0.441N     P=0.559     |P=0.543N     P=0.349      P=0.228      P=0.682      |
|LOGISTIC REGRESSION|     P=0.505N     P=0.280      P=0.440N     P=0.572     |P=0.544N     P=0.348      P=0.230      P=0.686      |
|COCH-ARM / FISHERS |     P=0.548N     P=0.290      P=0.487N     P=0.500     |P=0.512N     P=0.319      P=0.218      P=0.691N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/49 (18%)   6/50 (12%)   9/50 (18%)   7/49 (14%)  |2/50 (4%)    1/48 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     21.4%        14.9%        20.0%        15.5%       |4.4%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     8/31 (26%)   5/27 (19%)   9/40 (23%)   6/38 (16%)  |1/34 (3%)    1/37 (3%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     723          598          733 (T)      673         |614          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.218N     P=0.389N     P=0.367N     P=0.242N    |P=0.106N     P=0.486N     P=0.234N     P=0.254N     |
|POLY 3             |     P=0.348N     P=0.313N     P=0.541N     P=0.332N    |P=0.101N     P=0.501N     P=0.233N     P=0.244N     |
|POLY 1.5           |     P=0.385N     P=0.297N     P=0.563N     P=0.357N    |P=0.101N     P=0.506N     P=0.234N     P=0.241N     |
|POLY 6             |     P=0.305N     P=0.332N     P=0.504N     P=0.303N    |P=0.102N     P=0.495N     P=0.233N     P=0.248N     |
|LOGISTIC REGRESSION|     P=0.291N     P=0.360N     P=0.383N     P=0.285N    |P=0.100N     P=0.528N     P=0.253N     P=0.236N     |
|COCH-ARM / FISHERS |     P=0.438N     P=0.274N     P=0.584N     P=0.393N    |P=0.100N     P=0.515N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   6/50 (12%)   5/50 (10%)   3/49 (6%)   |6/50 (12%)   6/48 (13%)   4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     16.7%        15.0%        11.1%        6.7%        |13.4%        13.3%        8.7%         0.0%         |
|TERMINAL (d)       |     7/31 (23%)   5/27 (19%)   5/40 (13%)   3/38 (8%)   |5/34 (15%)   5/37 (14%)   4/35 (11%)   0/32 (0%)    |
|FIRST INCIDENCE    |     733 (T)      685          733 (T)      733 (T)     |704          672          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.043N*    P=0.605N     P=0.212N     P=0.085N    |P=0.013N*    P=0.557N     P=0.349N     P=0.021N*    |
|POLY 3             |     P=0.083N     P=0.535N     P=0.330N     P=0.130N    |P=0.011N*    P=0.615N     P=0.353N     P=0.016N*    |
|POLY 1.5           |     P=0.095N     P=0.515N     P=0.348N     P=0.141N    |P=0.011N*    P=0.614      P=0.357N     P=0.016N*    |
|POLY 6             |     P=0.071N     P=0.558N     P=0.303N     P=0.118N    |P=0.012N*    P=0.598N     P=0.351N     P=0.017N*    |
|LOGISTIC REGRESSION|     P=0.054N     P=0.596N     P=0.212N     P=0.085N    |P=0.012N*    P=0.598N     P=0.345N     P=0.019N*    |
|COCH-ARM / FISHERS |     P=0.114N     P=0.484N     P=0.365N     P=0.159N    |P=0.011N*    P=0.591      P=0.370N     P=0.013N*    |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fatty Change                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/48 (0%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         6.4%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    2/38 (5%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          640          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.064      (e)          (e)          P=0.284     |P=0.527      (e)          P=0.137      (e)          |
|POLY 3             |     P=0.049 *    (e)          (e)          P=0.252     |P=0.515      (e)          P=0.127      (e)          |
|POLY 1.5           |     P=0.047 *    (e)          (e)          P=0.246     |P=0.528      (e)          P=0.124      (e)          |
|POLY 6             |     P=0.052      (e)          (e)          P=0.260     |P=0.502      (e)          P=0.131      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.284     |P=0.545      (e)          P=0.091      (e)          |
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.247     |P=0.543      (e)          P=0.121      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/48 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.8%         5.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/31 (7%)    2/27 (7%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.058N     P=0.645      P=0.184N     P=0.195N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.079N     P=0.676      P=0.222N     P=0.222N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.082N     P=0.686      P=0.227N     P=0.228N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.077N     P=0.664      P=0.213N     P=0.215N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.058N     P=0.645      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.086N     P=0.684N     P=0.242N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/50 (0%)    2/49 (4%)   |1/50 (2%)    1/48 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         0.0%         4.4%        |2.2%         2.2%         2.2%         4.6%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |     684          598          ---          558         |681          527          570          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.412      P=0.734      P=0.475N     P=0.539     |P=0.334      P=0.755N     P=0.753N     P=0.483      |
|POLY 3             |     P=0.389      P=0.751      P=0.487N     P=0.526     |P=0.343      P=0.757N     P=0.753N     P=0.491      |
|POLY 1.5           |     P=0.379      P=0.757      P=0.492N     P=0.516     |P=0.349      P=0.759      P=0.755N     P=0.495      |
|POLY 6             |     P=0.401      P=0.745      P=0.480N     P=0.539     |P=0.335      P=0.752N     P=0.751N     P=0.485      |
|LOGISTIC REGRESSION|     P=0.324      P=0.743N     P=0.498N     P=0.466     |P=0.362      P=0.683      P=0.713      P=0.492      |
|COCH-ARM / FISHERS |     P=0.364      P=0.747N     P=0.495N     P=0.500     |P=0.356      P=0.742      P=0.753N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    1/49 (2%)   |1/50 (2%)    0/48 (0%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.9%         0.0%         2.2%        |2.2%         0.0%         4.3%         2.3%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          539          ---          672         |735 (T)      ---          687          588          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.580      P=0.226      (e)          P=0.515     |P=0.485      P=0.483N     P=0.519      P=0.749      |
|POLY 3             |     P=0.560      P=0.229      (e)          P=0.514     |P=0.489      P=0.499N     P=0.512      P=0.758      |
|POLY 1.5           |     P=0.551      P=0.234      (e)          P=0.508     |P=0.495      P=0.502N     P=0.508      P=0.759      |
|POLY 6             |     P=0.570      P=0.224      (e)          P=0.522     |P=0.482      P=0.494N     P=0.516      P=0.758      |
|LOGISTIC REGRESSION|     P=0.507      P=0.262      (e)          P=0.488     |P=0.511      (e)          P=0.506      P=0.763      |
|COCH-ARM / FISHERS |     P=0.538      P=0.253      (e)          P=0.500     |P=0.504      P=0.510N     P=0.500      P=0.753N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         4.3%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          687          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.474N     P=0.483N     P=0.519      P=0.512N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.472N     P=0.498N     P=0.512      P=0.504N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.466N     P=0.500N     P=0.508      P=0.502N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.479N     P=0.494N     P=0.516      P=0.507N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.463N     (e)          P=0.506      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.459N     P=0.505N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/48 (6%)    3/50 (6%)    5/50 (10%)   2/50 (4%)   |4/50 (8%)    4/49 (8%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.2%         7.5%         11.1%        4.4%        |9.0%         8.9%         0.0%         0.0%         |
|TERMINAL (d)       |     3/31 (10%)   2/27 (7%)    5/40 (13%)   2/38 (5%)   |3/34 (9%)    4/37 (11%)   0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     733 (T)      685          733 (T)      733 (T)     |734          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.301N     P=0.602      P=0.502      P=0.407N    |P=0.016N*    P=0.598N     P=0.062N     P=0.074N     |
|POLY 3             |     P=0.377N     P=0.646      P=0.399      P=0.460N    |P=0.013N*    P=0.637N     P=0.057N     P=0.063N     |
|POLY 1.5           |     P=0.396N     P=0.660      P=0.388      P=0.469N    |P=0.013N*    P=0.643      P=0.058N     P=0.062N     |
|POLY 6             |     P=0.355N     P=0.630      P=0.419      P=0.449N    |P=0.013N*    P=0.627N     P=0.056N     P=0.064N     |
|LOGISTIC REGRESSION|     P=0.337N     P=0.615      P=0.502      P=0.407N    |P=0.015N*    P=0.605N     P=0.059N     P=0.069N     |
|COCH-ARM / FISHERS |     P=0.424N     P=0.641N     P=0.381      P=0.480N    |P=0.014N*    P=0.631      P=0.059N     P=0.059N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Infiltration Cellular Plasma Cell                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/34 (0%)    0/28 (0%)    0/35 (0%)    0/37 (0%)   |2/29 (7%)    0/32 (0%)    0/37 (0%)    0/36 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |7.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/17 (0%)    0/30 (0%)    0/31 (0%)   |0/19 (0%)    0/25 (0%)    0/25 (0%)    0/23 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |507          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.237N     P=0.232N     P=0.250N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.089N     P=0.210N     P=0.186N     P=0.200N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.090N     P=0.211N     P=0.183N     P=0.194N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.089N     P=0.210N     P=0.190N     P=0.208N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.116N     P=0.294N     P=0.255N     P=0.210N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.093N     P=0.222N     P=0.189N     P=0.195N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    0/44 (0%)    0/47 (0%)    0/47 (0%)   |4/47 (9%)    0/48 (0%)    1/46 (2%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |9.4%         0.0%         2.4%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/25 (0%)    0/38 (0%)    0/36 (0%)   |4/33 (12%)   0/37 (0%)    1/33 (3%)    0/30 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.045N*    P=0.049N*    P=0.178N     P=0.075N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.041N*    P=0.053N     P=0.177N     P=0.067N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.040N*    P=0.054N     P=0.179N     P=0.065N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.042N*    P=0.051N     P=0.175N     P=0.069N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.045N*    (e)          P=0.178N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.041N*    P=0.056N     P=0.187N     P=0.061N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/2 (0%)     0/2 (0%)     0/3 (0%)     0/5 (0%)    |2/12 (17%)   0/6 (0%)     0/5 (0%)     0/6 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |18.4%        0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/1 (0%)     0/3 (0%)    |0/6 (0%)     0/4 (0%)     0/3 (0%)     0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |507          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.247N     P=0.240N     P=0.252N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.205N     P=0.396N     P=0.455N     P=0.386N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.204N     P=0.397N     P=0.451N     P=0.391N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.206N     P=0.393N     P=0.458N     P=0.381N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.431N     P=0.485N     P=0.431N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/2 (50%)    2/2 (100%)   2/3 (67%)    5/5 (100%)  |9/12 (75%)   5/6 (83%)    3/5 (60%)    4/6 (67%)    |
|POLY-3 ADJUSTED (b)|     55.2%        100.0%       66.7%        100.0%      |84.1%        84.8%        69.0%        68.7%        |
|TERMINAL (d)       |     1/1 (100%)   1/1 (100%)   0/1 (0%)     3/3 (100%)  |5/6 (83%)    4/4 (100%)   3/3 (100%)   2/2 (100%)   |
|FIRST INCIDENCE    |     733 (T)      685          504          672         |614          610          735 (T)      707          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.192      P=0.480      P=0.546      P=0.256     |P=0.417N     P=0.300N     P=0.142N     P=0.438N     |
|POLY 3             |     P=0.262      P=0.569      P=0.715      P=0.380     |P=0.302N     P=0.758      P=0.522N     P=0.459N     |
|POLY 1.5           |     P=0.234      P=0.533      P=0.693      P=0.329     |P=0.339N     P=0.685      P=0.496N     P=0.504N     |
|POLY 6             |     P=0.317      P=0.650      P=0.755      P=0.507     |P=0.279N     P=0.764N     P=0.593N     P=0.430N     |
|LOGISTIC REGRESSION|     P=0.200      (e)          P=0.787      P=0.265     |P=0.142N     P=0.735N     P=0.338N     P=0.291N     |
|COCH-ARM / FISHERS |     P=0.202      P=0.500      P=0.700      P=0.286     |P=0.396N     P=0.593      P=0.472N     P=0.561N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/48 (13%)   4/50 (8%)    3/50 (6%)    5/50 (10%)  |6/50 (12%)   7/49 (14%)   13/50 (26%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     14.2%        9.8%         6.5%         11.0%       |13.3%        15.5%        27.7%        30.0%        |
|TERMINAL (d)       |     5/31 (16%)   3/27 (11%)   1/40 (3%)    4/38 (11%)  |3/34 (9%)    6/37 (16%)   7/35 (20%)   4/32 (13%)   |
|FIRST INCIDENCE    |     516          476          516          723         |664          708          666          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.325N     P=0.443N     P=0.171N     P=0.372N    |P=0.015 *    P=0.564      P=0.091      P=0.048 *    |
|POLY 3             |     P=0.405N     P=0.394N     P=0.201N     P=0.448N    |P=0.018 *    P=0.501      P=0.072      P=0.043 *    |
|POLY 1.5           |     P=0.422N     P=0.373N     P=0.212N     P=0.458N    |P=0.017 *    P=0.496      P=0.068      P=0.041 *    |
|POLY 6             |     P=0.385N     P=0.418N     P=0.183N     P=0.436N    |P=0.020 *    P=0.508      P=0.076      P=0.047 *    |
|LOGISTIC REGRESSION|     P=0.449N     P=0.356N     P=0.227N     P=0.444N    |P=0.017 *    P=0.511      P=0.067      P=0.041 *    |
|COCH-ARM / FISHERS |     P=0.445N     P=0.344N     P=0.223N     P=0.471N    |P=0.017 *    P=0.484      P=0.062      P=0.039 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/49 (2%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         0.0%         4.4%        |0.0%         2.2%         6.4%         6.9%         |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    0/40 (0%)    1/38 (3%)   |0/34 (0%)    1/37 (3%)    0/35 (0%)    3/32 (9%)    |
|FIRST INCIDENCE    |     733 (T)      706          ---          723         |---          735 (T)      502          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.442      P=0.735      P=0.449N     P=0.570     |P=0.058      P=0.517      P=0.132      P=0.110      |
|POLY 3             |     P=0.395      P=0.752      P=0.485N     P=0.531     |P=0.063      P=0.502      P=0.129      P=0.115      |
|POLY 1.5           |     P=0.387      P=0.759      P=0.489N     P=0.524     |P=0.065      P=0.500      P=0.126      P=0.117      |
|POLY 6             |     P=0.404      P=0.744      P=0.478N     P=0.539     |P=0.060      P=0.506      P=0.133      P=0.112      |
|LOGISTIC REGRESSION|     P=0.414      P=0.744      (e)          P=0.550     |P=0.073      P=0.517      P=0.056      P=0.110      |
|COCH-ARM / FISHERS |     P=0.375      P=0.742N     P=0.490N     P=0.515     |P=0.069      P=0.495      P=0.121      P=0.121      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    1/50 (2%)    5/50 (10%)   2/50 (4%)   |11/50 (22%)  10/49 (20%)  15/50 (30%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         11.1%        4.3%        |24.6%        22.1%        32.4%        22.1%        |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    4/40 (10%)   1/38 (3%)   |10/34 (29%)  7/37 (19%)   12/35 (34%)  7/32 (22%)   |
|FIRST INCIDENCE    |     733 (T)      706          715          589         |708          708          672          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.409      P=0.735      P=0.172      P=0.557     |P=0.483      P=0.410N     P=0.280      P=0.550N     |
|POLY 3             |     P=0.370      P=0.752      P=0.120      P=0.535     |P=0.513N     P=0.486N     P=0.276      P=0.489N     |
|POLY 1.5           |     P=0.347      P=0.759      P=0.115      P=0.526     |P=0.508N     P=0.499N     P=0.268      P=0.489N     |
|POLY 6             |     P=0.399      P=0.744      P=0.129      P=0.545     |P=0.524N     P=0.464N     P=0.285      P=0.490N     |
|LOGISTIC REGRESSION|     P=0.347      P=0.744      P=0.142      P=0.506     |P=0.543      P=0.434N     P=0.277      P=0.509N     |
|COCH-ARM / FISHERS |     P=0.314      P=0.742N     P=0.112      P=0.515     |P=0.515N     P=0.521N     P=0.247      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/48 (10%)   3/50 (6%)    6/50 (12%)   10/50 (20%) |16/50 (32%)  35/49 (71%)  32/50 (64%)  30/50 (60%)  |
|POLY-3 ADJUSTED (b)|     11.8%        7.5%         13.3%        21.5%       |35.8%        72.6%        67.3%        60.9%        |
|TERMINAL (d)       |     3/31 (10%)   3/27 (11%)   6/40 (15%)   8/38 (21%)  |15/34 (44%)  27/37 (73%)  25/35 (71%)  16/32 (50%)  |
|FIRST INCIDENCE    |     602          733 (T)      733 (T)      558         |708          463          524          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.104      P=0.436N     P=0.601N     P=0.225     |P=0.017 *    P<0.001 **   P=0.002 **   P=0.006 **   |
|POLY 3             |     P=0.063      P=0.388N     P=0.543      P=0.176     |P=0.071      P<0.001 **   P<0.001 **   P=0.011 *    |
|POLY 1.5           |     P=0.054      P=0.365N     P=0.534      P=0.165     |P=0.048 *    P<0.001 **   P<0.001 **   P=0.007 **   |
|POLY 6             |     P=0.074      P=0.417N     P=0.559      P=0.188     |P=0.112      P<0.001 **   P=0.002 **   P=0.017 *    |
|LOGISTIC REGRESSION|     P=0.060      P=0.384N     P=0.555      P=0.151     |P=0.027 *    P<0.001 **   P=0.002 **   P=0.005 **   |
|COCH-ARM / FISHERS |     P=0.044 *    P=0.335N     P=0.529      P=0.150     |P=0.028 *    P<0.001 **   P<0.001 **   P=0.004 **   |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    5/50 (10%)   6/50 (12%)   9/50 (18%)  |7/50 (14%)   11/49 (22%)  16/50 (32%)  21/50 (42%)  |
|POLY-3 ADJUSTED (b)|     4.8%         12.0%        13.1%        19.3%       |15.5%        24.2%        33.2%        44.6%        |
|TERMINAL (d)       |     2/31 (7%)    2/27 (7%)    4/40 (10%)   4/38 (11%)  |4/34 (12%)   10/37 (27%)  9/35 (26%)   9/32 (28%)   |
|FIRST INCIDENCE    |     733 (T)      402          516          589         |664          672          502          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.057      P=0.182      P=0.218      P=0.059     |P<0.001 **   P=0.282      P=0.048 *    P=0.004 **   |
|POLY 3             |     P=0.033 *    P=0.215      P=0.164      P=0.040 *   |P<0.001 **   P=0.217      P=0.038 *    P=0.002 **   |
|POLY 1.5           |     P=0.027 *    P=0.223      P=0.155      P=0.035 *   |P<0.001 **   P=0.213      P=0.034 *    P<0.001 **   |
|POLY 6             |     P=0.040 *    P=0.207      P=0.180      P=0.046 *   |P<0.001 **   P=0.224      P=0.043 *    P=0.002 **   |
|LOGISTIC REGRESSION|     P=0.019 *    P=0.266      P=0.151      P=0.033 *   |P<0.001 **   P=0.228      P=0.026 *    P=0.002 **   |
|COCH-ARM / FISHERS |     P=0.022 *    P=0.235      P=0.148      P=0.030 *   |P<0.001 **   P=0.204      P=0.028 *    P=0.002 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Turbinate                                                                                                                  |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    3/49 (6%)    1/50 (2%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.4%         0.0%        |0.0%         6.6%         2.2%         8.8%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |0/34 (0%)    2/37 (5%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     ---          ---          516          ---         |---          708          704          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.625      (e)          P=0.265      (e)         |P=0.064      P=0.141      P=0.511      P=0.061      |
|POLY 3             |     P=0.639      (e)          P=0.258      (e)         |P=0.074      P=0.121      P=0.506      P=0.062      |
|POLY 1.5           |     P=0.624      (e)          P=0.252      (e)         |P=0.074      P=0.119      P=0.504      P=0.062      |
|POLY 6             |     P=0.656      (e)          P=0.267      (e)         |P=0.075      P=0.125      P=0.508      P=0.063      |
|LOGISTIC REGRESSION|     P=0.576      (e)          P=0.247      (e)         |P=0.078      P=0.125      P=0.500      P=0.053      |
|COCH-ARM / FISHERS |     P=0.602      (e)          P=0.258      (e)         |P=0.073      P=0.117      P=0.500      P=0.059      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |16/49 (33%)  12/47 (26%)  18/49 (37%)  18/50 (36%)  |
|POLY-3 ADJUSTED (b)|                                                        |35.8%        27.2%        38.8%        40.0%        |
|TERMINAL (d)       |                                                        |13/34 (38%)  11/36 (31%)  13/35 (37%)  14/32 (44%)  |
|FIRST INCIDENCE    |                                                        |532          672          524          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.169      P=0.197N     P=0.462      P=0.351      |
|POLY 3             |                                                        |P=0.247      P=0.259N     P=0.469      P=0.425      |
|POLY 1.5           |                                                        |P=0.262      P=0.270N     P=0.453      P=0.437      |
|POLY 6             |                                                        |P=0.230      P=0.244N     P=0.486      P=0.411      |
|LOGISTIC REGRESSION|                                                        |P=0.243      P=0.240N     P=0.450      P=0.419      |
|COCH-ARM / FISHERS |                                                        |P=0.277      P=0.294N     P=0.416      P=0.445      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Duct                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/49 (0%)    1/50 (2%)    0/48 (0%)   |1/50 (2%)    0/48 (0%)    2/49 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.2%         0.0%        |2.2%         0.0%         4.4%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    2/35 (6%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          733 (T)      ---         |735 (T)      ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.728      (e)          P=0.551      (e)         |P=0.483N     P=0.483N     P=0.510      P=0.512N     |
|POLY 3             |     P=0.733      (e)          P=0.519      (e)         |P=0.477N     P=0.499N     P=0.504      P=0.507N     |
|POLY 1.5           |     P=0.720      (e)          P=0.515      (e)         |P=0.471N     P=0.502N     P=0.501      P=0.506N     |
|POLY 6             |     P=0.746      (e)          P=0.526      (e)         |P=0.483N     P=0.494N     P=0.507      P=0.509N     |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.551      (e)         |P=0.483N     (e)          P=0.510      (e)          |
|COCH-ARM / FISHERS |     P=0.698      (e)          P=0.515      (e)         |P=0.463N     P=0.510N     P=0.492      P=0.505N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/46 (4%)    1/47 (2%)    2/48 (4%)    4/47 (9%)   |19/49 (39%)  24/49 (49%)  23/49 (47%)  28/50 (56%)  |
|POLY-3 ADJUSTED (b)|     5.0%         2.6%         4.7%         9.1%        |41.6%        50.6%        49.2%        61.1%        |
|TERMINAL (d)       |     1/30 (3%)    1/27 (4%)    2/38 (5%)    4/37 (11%)  |14/34 (41%)  18/37 (49%)  16/35 (46%)  20/32 (63%)  |
|FIRST INCIDENCE    |     684          733 (T)      733 (T)      733 (T)     |507          463          570          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.248      P=0.541N     P=0.617N     P=0.425     |P=0.037 *    P=0.329      P=0.334      P=0.046 *    |
|POLY 3             |     P=0.200      P=0.517N     P=0.667N     P=0.381     |P=0.046 *    P=0.253      P=0.299      P=0.045 *    |
|POLY 1.5           |     P=0.188      P=0.507N     P=0.674N     P=0.368     |P=0.055      P=0.238      P=0.293      P=0.052      |
|POLY 6             |     P=0.213      P=0.527N     P=0.656N     P=0.393     |P=0.038 *    P=0.274      P=0.305      P=0.038 *    |
|LOGISTIC REGRESSION|     P=0.225      P=0.522N     P=0.660N     P=0.400     |P=0.060      P=0.211      P=0.293      P=0.052      |
|COCH-ARM / FISHERS |     P=0.168      P=0.492N     P=0.675N     P=0.349     |P=0.069      P=0.208      P=0.270      P=0.065      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    2/49 (4%)    2/50 (4%)    0/47 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.8%         5.1%         4.4%         0.0%        |                                                    |
|TERMINAL (d)       |     1/31 (3%)    1/27 (4%)    2/40 (5%)    0/36 (0%)   |                                                    |
|FIRST INCIDENCE    |     716          588          733 (T)      ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.649      P=0.603N     P=0.206N    |                                                    |
|POLY 3             |     P=0.150N     P=0.675      P=0.667N     P=0.231N    |                                                    |
|POLY 1.5           |     P=0.157N     P=0.685      P=0.674N     P=0.235N    |                                                    |
|POLY 6             |     P=0.142N     P=0.664      P=0.655N     P=0.226N    |                                                    |
|LOGISTIC REGRESSION|     P=0.154N     P=0.689      P=0.641N     P=0.223N    |                                                    |
|COCH-ARM / FISHERS |     P=0.166N     P=0.684N     P=0.676N     P=0.253N    |                                                    |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Prepuce                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/48 (13%)   7/50 (14%)   4/50 (8%)    5/48 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     13.7%        16.3%        8.9%         10.9%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/31 (7%)    2/27 (7%)    2/40 (5%)    1/37 (3%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     359          420          702          327         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.267N     P=0.441      P=0.280N     P=0.439N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.314N     P=0.487      P=0.348N     P=0.463N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.332N     P=0.503      P=0.351N     P=0.478N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.294N     P=0.469      P=0.337N     P=0.446N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.484N     P=0.556N     P=0.350N     P=0.613     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.356N     P=0.532      P=0.344N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/48 (25%)  14/48 (29%)  12/50 (24%)  7/48 (15%)  |11/50 (22%)  8/48 (17%)   8/48 (17%)   12/49 (24%)  |
|POLY-3 ADJUSTED (b)|     27.0%        30.9%        25.5%        14.9%       |22.9%        17.1%        17.6%        26.2%        |
|TERMINAL (d)       |     2/31 (7%)    1/27 (4%)    8/40 (20%)   1/38 (3%)   |2/34 (6%)    3/37 (8%)    4/35 (11%)   3/32 (9%)    |
|FIRST INCIDENCE    |     532          402          492          504         |248          492          570          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.055N     P=0.335      P=0.425N     P=0.121N    |P=0.335      P=0.280N     P=0.296N     P=0.472      |
|POLY 3             |     P=0.062N     P=0.431      P=0.529N     P=0.123N    |P=0.325      P=0.329N     P=0.354N     P=0.444      |
|POLY 1.5           |     P=0.070N     P=0.425      P=0.539N     P=0.132N    |P=0.338      P=0.334N     P=0.349N     P=0.457      |
|POLY 6             |     P=0.056N     P=0.433      P=0.516N     P=0.114N    |P=0.313      P=0.322N     P=0.360N     P=0.434      |
|LOGISTIC REGRESSION|     P=0.229N     P=0.595      P=0.568N     P=0.303N    |P=0.451      P=0.513N     P=0.461N     P=0.539      |
|COCH-ARM / FISHERS |     P=0.085N     P=0.409      P=0.547N     P=0.153N    |P=0.359      P=0.341N     P=0.341N     P=0.478      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    2/48 (4%)    0/50 (0%)    0/48 (0%)   |4/50 (8%)    2/48 (4%)    1/48 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         0.0%        |9.0%         4.5%         2.2%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    1/27 (4%)    0/40 (0%)    0/38 (0%)   |4/34 (12%)   2/37 (5%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          402          ---          ---         |735 (T)      735 (T)      735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.378N     P=0.225      (e)          (e)         |P=0.032N*    P=0.298N     P=0.170N     P=0.070N     |
|POLY 3             |     P=0.397N     P=0.226      (e)          (e)         |P=0.032N*    P=0.334N     P=0.179N     P=0.065N     |
|POLY 1.5           |     P=0.399N     P=0.231      (e)          (e)         |P=0.031N*    P=0.342N     P=0.183N     P=0.064N     |
|POLY 6             |     P=0.395N     P=0.222      (e)          (e)         |P=0.032N*    P=0.324N     P=0.174N     P=0.065N     |
|LOGISTIC REGRESSION|     P=0.495N     P=0.287      (e)          (e)         |P=0.032N*    P=0.298N     P=0.170N     (e)          |
|COCH-ARM / FISHERS |     P=0.404N     P=0.247      (e)          (e)         |P=0.031N*    P=0.359N     P=0.194N     P=0.061N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    1/49 (2%)    1/50 (2%)    0/48 (0%)   |1/50 (2%)    0/49 (0%)    1/48 (2%)    1/48 (2%)    |
|POLY-3 ADJUSTED (b)|     4.8%         2.5%         2.2%         0.0%        |2.2%         0.0%         2.2%         2.3%         |
|TERMINAL (d)       |     2/31 (7%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     733 (T)      364          516          ---         |735 (T)      ---          640          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.132N     P=0.530N     P=0.444N     P=0.195N    |P=0.519      P=0.483N     P=0.752N     P=0.748      |
|POLY 3             |     P=0.138N     P=0.512N     P=0.468N     P=0.221N    |P=0.523      P=0.498N     P=0.759N     P=0.752      |
|POLY 1.5           |     P=0.143N     P=0.504N     P=0.477N     P=0.227N    |P=0.526      P=0.500N     P=0.758      P=0.752      |
|POLY 6             |     P=0.131N     P=0.522N     P=0.454N     P=0.214N    |P=0.519      P=0.494N     P=0.755N     P=0.751      |
|LOGISTIC REGRESSION|     P=0.201N     P=0.434N     P=0.489N     (e)         |P=0.529      (e)          P=0.744      P=0.748      |
|COCH-ARM / FISHERS |     P=0.151N     P=0.492N     P=0.485N     P=0.247N    |P=0.529      P=0.505N     P=0.742      P=0.742      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    1/49 (2%)    0/50 (0%)    0/48 (0%)   |0/50 (0%)    1/49 (2%)    2/48 (4%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     4.8%         2.5%         0.0%         0.0%        |0.0%         2.2%         4.5%         0.0%         |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    1/37 (3%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     626          364          ---          ---         |---          735 (T)      640          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.089N     P=0.525N     P=0.207N     P=0.208N    |P=0.637N     P=0.517      P=0.248      (e)          |
|POLY 3             |     P=0.094N     P=0.516N     P=0.222N     P=0.223N    |P=0.627N     P=0.502      P=0.238      (e)          |
|POLY 1.5           |     P=0.096N     P=0.506N     P=0.225N     P=0.228N    |P=0.625N     P=0.500      P=0.235      (e)          |
|POLY 6             |     P=0.092N     P=0.528N     P=0.216N     P=0.218N    |P=0.629N     P=0.506      P=0.243      (e)          |
|LOGISTIC REGRESSION|     P=0.122N     P=0.405N     P=0.230N     P=0.256N    |P=0.626N     P=0.517      P=0.213      (e)          |
|COCH-ARM / FISHERS |     P=0.099N     P=0.492N     P=0.237N     P=0.247N    |P=0.626N     P=0.495      P=0.237      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Infiltration Cellular Mixed Cell                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    2/47 (4%)    0/50 (0%)    0/48 (0%)   |0/50 (0%)    0/48 (0%)    1/48 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.3%         0.0%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    2/27 (7%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.350N     P=0.208      (e)          (e)         |P=0.686      (e)          P=0.506      (e)          |
|POLY 3             |     P=0.396N     P=0.224      (e)          (e)         |P=0.682      (e)          P=0.500      (e)          |
|POLY 1.5           |     P=0.395N     P=0.231      (e)          (e)         |P=0.686      (e)          P=0.497      (e)          |
|POLY 6             |     P=0.398N     P=0.216      (e)          (e)         |P=0.677      (e)          P=0.502      (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.208      (e)          (e)         |(e)          (e)          P=0.506      (e)          |
|COCH-ARM / FISHERS |     P=0.395N     P=0.253      (e)          (e)         |P=0.690      (e)          P=0.490      (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/48 (29%)  9/49 (18%)   11/49 (22%)  19/49 (39%) |26/50 (52%)  24/48 (50%)  30/50 (60%)  37/50 (74%)  |
|POLY-3 ADJUSTED (b)|     33.6%        22.9%        25.0%        42.1%       |56.7%        53.4%        63.8%        82.4%        |
|TERMINAL (d)       |     13/31 (42%)  8/27 (30%)   10/39 (26%)  18/38 (47%) |22/34 (65%)  23/37 (62%)  25/35 (71%)  29/32 (91%)  |
|FIRST INCIDENCE    |     723          723          715          672         |614          714          570          631          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.279      P=0.270N     P=0.122N     P=0.435     |P<0.001 **   P=0.258N     P=0.336      P=0.008 **   |
|POLY 3             |     P=0.124      P=0.204N     P=0.261N     P=0.273     |P=0.002 **   P=0.456N     P=0.311      P=0.004 **   |
|POLY 1.5           |     P=0.103      P=0.183N     P=0.282N     P=0.248     |P=0.003 **   P=0.467N     P=0.304      P=0.008 **   |
|POLY 6             |     P=0.153      P=0.229N     P=0.226N     P=0.310     |P<0.001 **   P=0.443N     P=0.313      P=0.002 **   |
|LOGISTIC REGRESSION|     P=0.209      P=0.256N     P=0.141N     P=0.353     |P<0.001 **   P=0.346N     P=0.331      P=0.004 **   |
|COCH-ARM / FISHERS |     P=0.082      P=0.156N     P=0.300N     P=0.217     |P=0.007 **   P=0.502N     P=0.273      P=0.019 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Developmental Malformation                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/13 (92%)  17/17 (100%) 10/10 (100%) 19/19 (100%)|0/0 (0%)     1/1 (100%)   0/0 (0%)     1/1 (100%)   |
|POLY-3 ADJUSTED (b)|     92.3%        100.0%       100.0%       100.0%      |0.0%         100.0%       0.0%         100.0%       |
|TERMINAL (d)       |     9/10 (90%)   14/14 (100%) 9/9 (100%)   17/17 (100%)|0/0 (0%)     1/1 (100%)   0/0 (0%)     1/1 (100%)   |
|FIRST INCIDENCE    |     602          666          504          558         |---          735 (T)      ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.437N     P=0.419      P=0.445N     P=0.648N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.278      P=0.446      P=0.552      P=0.424     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.278      P=0.446      P=0.552      P=0.424     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.278      P=0.446      P=0.552      P=0.424     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.278      P=0.433      P=0.565      P=0.406     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/13 (15%)   0/17 (0%)    0/10 (0%)    1/19 (5%)   |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/1 (0%)     |
|POLY-3 ADJUSTED (b)|     15.5%        0.0%         0.0%         5.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/10 (10%)   0/14 (0%)    0/9 (0%)     0/17 (0%)   |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/1 (0%)     |
|FIRST INCIDENCE    |     602          ---          ---          723         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.394N     P=0.222N     P=0.246N     P=0.414N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.387N     P=0.174N     P=0.308N     P=0.373N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.388N     P=0.173N     P=0.302N     P=0.371N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.385N     P=0.177N     P=0.312N     P=0.375N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.367N     P=0.287N     P=0.207N     P=0.358N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.389N     P=0.179N     P=0.308N     P=0.356N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/47 (6%)    1/48 (2%)    1/50 (2%)    1/47 (2%)   |0/48 (0%)    0/48 (0%)    0/48 (0%)    0/47 (0%)    |
|POLY-3 ADJUSTED (b)|     7.1%         2.6%         2.2%         2.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     454          706          733 (T)      504         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.212N     P=0.345N     P=0.274N     P=0.295N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.214N     P=0.338N     P=0.282N     P=0.283N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.224N     P=0.322N     P=0.285N     P=0.291N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.204N     P=0.357N     P=0.277N     P=0.276N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.322N     P=0.239N     P=0.278N     P=0.629N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.240N     P=0.301N     P=0.285N     P=0.308N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    1/48 (2%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.5%         2.2%         2.2%         0.0%         |
|TERMINAL (d)       |                                                        |2/34 (6%)    1/37 (3%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      735 (T)      735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.163N     P=0.470N     P=0.490N     P=0.252N     |
|POLY 3             |                                                        |P=0.161N     P=0.498N     P=0.496N     P=0.245N     |
|POLY 1.5           |                                                        |P=0.159N     P=0.504N     P=0.499N     P=0.244N     |
|POLY 6             |                                                        |P=0.163N     P=0.490N     P=0.493N     P=0.246N     |
|LOGISTIC REGRESSION|                                                        |P=0.163N     P=0.470N     P=0.490N     (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.155N     P=0.515N     P=0.508N     P=0.253N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    7/48 (15%)   3/49 (6%)    5/49 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |6.7%         15.6%        6.6%         11.6%        |
|TERMINAL (d)       |                                                        |2/34 (6%)    7/37 (19%)   3/35 (9%)    4/32 (13%)   |
|FIRST INCIDENCE    |                                                        |614          735 (T)      735 (T)      685          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.412      P=0.189      P=0.649N     P=0.329      |
|POLY 3             |                                                        |P=0.445      P=0.155      P=0.661N     P=0.333      |
|POLY 1.5           |                                                        |P=0.453      P=0.151      P=0.661      P=0.339      |
|POLY 6             |                                                        |P=0.438      P=0.161      P=0.660N     P=0.328      |
|LOGISTIC REGRESSION|                                                        |P=0.433      P=0.162      P=0.663N     P=0.338      |
|COCH-ARM / FISHERS |                                                        |P=0.461      P=0.142      P=0.651      P=0.346      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Infiltration Cellular Polymorphonuclear                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    1/48 (2%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.5%         2.2%         0.0%         2.3%         |
|TERMINAL (d)       |                                                        |0/34 (0%)    1/37 (3%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |248          735 (T)      ---          701          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.212N     P=0.288N     P=0.120N     P=0.317N     |
|POLY 3             |                                                        |P=0.206N     P=0.314N     P=0.122N     P=0.328N     |
|POLY 1.5           |                                                        |P=0.205N     P=0.317N     P=0.122N     P=0.323N     |
|POLY 6             |                                                        |P=0.208N     P=0.309N     P=0.122N     P=0.333N     |
|LOGISTIC REGRESSION|                                                        |P=0.214N     P=0.464N     P=0.217N     P=0.325N     |
|COCH-ARM / FISHERS |                                                        |P=0.203N     P=0.324N     P=0.125N     P=0.316N     |
|=================================================================================================================================|
(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).