TDMS Study 05184-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest GLUTARALDEHYDE DATE: 07/13/98
EXPERIMENT: 05184 TEST: 06 TIME: 08:41:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55425C
PATHOLOGIST: GRUMBEIN, S. CAS: 111-30-8
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest GLUTARALDEHYDE DATE: 07/13/98
EXPERIMENT: 05184 TEST: 06 TIME: 08:41:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55425C
PATHOLOGIST: GRUMBEIN, S. CAS: 111-30-8
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 359 454 498 516 532 534 573 602 616 626 |
| 670 675 684 684 688 702 712 716 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 62.5 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 364 402 420 476 517 524 524 539 551 573 |
| 588 598 616 640 640 647 666 685 698 706 |
| 707 718 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 279 470 492 504 516 519 605 702 715 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 327 504 558 589 628 641 651 663 672 673 |
| 704 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 96.0 88.0 84.0 80.0 62.0 |
| | |
| | |
|62.5 PPB | 100.0 100.0 100.0 98.0 94.0 92.0 84.0 76.0 68.0 54.0 |
| | |
| | |
|125 PPB | 100.0 100.0 100.0 98.0 98.0 96.0 88.0 86.0 86.0 80.0 |
| | |
| | |
|250 PPB | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 92.0 84.0 76.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 62.5 PPB 125 PPB 250 PPB |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 54.0% 80.0% 76.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.036N P=0.464 P=0.091N P=0.192N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 608.6 587.9 552.1 611.1 |
|NATURAL DEATHS (C) | (23.6) (21.9) (43.4) (31.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 685.7 666.3 696.8 703.7 |
|(STANDARD ERROR) | (12.3) (14.4) (13.3) (10.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 248 507 532 558 614 616 655 657 664 681 |
| 686 701 702 704 708 734 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 62.5 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 463 492 527 551 598 610 672 706 707 708 |
| 708 714 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 1 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 502 524 570 635 640 672 672 686 687 702 |
| 704 715 719 723 |
| CENSORED DEATHS |
| 666 |
| |
==================================================================================
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 PPB |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 401 492 502 542 552 560 588 616 631 660 |
| 685 686 701 707 712 723 723 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GLUTARALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 98.0 98.0 94.0 92.0 82.0 68.0 |
| | |
| | |
|62.5 PPB | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 90.0 88.0 74.0 |
| | |
| | |
|125 PPB | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 94.0 90.0 71.6 |
| | |
| | |
|250 PPB | 100.0 100.0 100.0 100.0 98.0 98.0 92.0 86.0 80.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 62.5 PPB 125 PPB 250 PPB |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 74.0% 71.6% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.573 P=0.611N P=0.771N P=0.811 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 622.9 629.5 653.6 622.4 |
|NATURAL DEATHS (C) | (30.0) (26.3) (19.3) (22.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 699.1 707.6 710.8 694.5 |
|(STANDARD ERROR) | (12.0) ( 9.4) ( 7.5) (11.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GLUTARALDEHYDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
62.5 PPB = 2
125 PPB = 3
250 PPB = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 3 4 1
|
| 3 4 1 2 1 3 4
| 2 2 1 3 31 4
95 +
| 2 2 31 1 4 4
| 2 3 1 1 4 4
|
90 + 2 211 4 4
|
| 3 1 1 3 44
| 2 2 1 13 4 4 3
P 85 +
E | 2 2 1 1 44 3 3
R | 2 2 1 1 44
C |
E 80 + 2 2 1 14 4 3 3
N |
T | 2 2 11 4 4
| 2 2 11 4 4
S 75 +
U | 2 2
R | 11
V |
I 70 + 22 1 1
V |
A | 2 2 11
L | 2 2 11
65 +
| 2 2 11
| 22 1 1
|
60 +
|
| 2 2
| 22
55 +
| 2 2
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
GLUTARALDEHYDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
62.5 PPB = 2
125 PPB = 3
250 PPB = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 2 3
|
| 1 4 2 231 3
| 241 31 3
95 +
| 4 1 421 3 3
| 421 2 1 33
|
P 90 + 44 2 2 3 3
E |
R | 4 4 1 1 2
C | 4 4 2 3 2
E 85 +
N | 4 4 1 1 33
T | 4 1 1 22
| 3 3
S 80 + 4 4
U |
R | 1 1 3
V | 4 42 2
I 75 +
V | 32 2
A | 11
L | 3 3
70 + 1 4 1
|
| 1
|
65 +
| 4 4
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.