TDMS Study 05184-06 Pathology Tables
NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 CORE STUDY Facility: Battelle Northwest Chemical CAS #: 111-30-8 Lock Date: 07/01/97 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to days on test Page 1 NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 2| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 0| 3| 5| 1| 1| 5| 5| 6| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 7| 2| 8| 4| 6| 5| 7| 4| 1| 6| 1| 2| 4| 8| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 4| 3| 1| 2| 1| 3| 2| 1| 3| 0| 2| 3| 0| 3| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 4| | 5| 4| 9| 3| 4| 5| 1| 3| 6| 6| 5| 0| 1| 1| 0| 1| 3| 9| 0| 2| 7| 4| 7| 8| 8| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + A + + A + + + + + + + + + + + + + + + M +| Histiocytic Sarcoma | X | __________________________________________________________________________| Intestine Large, Colon | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | A + + + A + + + + + + + + I + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + A + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + A + + A + + + + + A + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + A + + A + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + A + + A + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X X | __________________________________________________________________________| Mesentery | + + + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + M + + M + + + M + M + M + + + M M M + + +| __________________________________________________________________________| Pituitary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X | Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + M + + + + + + + + + + + M + M + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + I + + + + + + + + + +| Cystadenoma | | Luteoma | X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 2| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 0| 3| 5| 1| 1| 5| 5| 6| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 7| 2| 8| 4| 6| 5| 7| 4| 1| 6| 1| 2| 4| 8| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 4| 3| 1| 2| 1| 3| 2| 1| 3| 0| 2| 3| 0| 3| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 4| | 5| 4| 9| 3| 4| 5| 1| 3| 6| 6| 5| 0| 1| 1| 0| 1| 3| 9| 0| 2| 7| 4| 7| 8| 8| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Benign | X | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | + + + + + + + | Pancreatic, Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + M M + M M + + + + + M + + + + M M + + M M| Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + M + M M + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + M + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M M + + + + + + + + + + M + + M M M M + M| Carcinoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Thymus | M M + + + + + + + + + + + + M + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Carcinoma | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Sarcoma, | | Multiple | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 2| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 0| 3| 5| 1| 1| 5| 5| 6| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 7| 2| 8| 4| 6| 5| 7| 4| 1| 6| 1| 2| 4| 8| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 4| 3| 1| 2| 1| 3| 2| 1| 3| 0| 2| 3| 0| 3| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 4| | 5| 4| 9| 3| 4| 5| 1| 3| 6| 6| 5| 0| 1| 1| 0| 1| 3| 9| 0| 2| 7| 4| 7| 8| 8| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pleura | + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Sarcoma | | __________________________________________________________________________| Urinary Bladder | + + + M + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X X X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 0| 0| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 0| 0| 0| 1| 2| 3| 3| 3| 4| 4| L | | 2| 8| 5| 6| 8| 2| 8| 9| 7| 0| 3| 4| 6| 7| 0| 4| 5| 7| 1| 6| 2| 3| 9| 2| 9| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + +| 45 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X | 3 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X | 6 | Hepatocellular Adenoma, Multiple | X X X | 5 | __________________________________________________________________________|____________| Mesentery | + + + + + +| 12 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X X X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + I M + + + M M M + + + M M + M + M M + M M M M +| 27 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X X X | 20 | Pars Distalis, Carcinoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 0| 0| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 0| 0| 0| 1| 2| 3| 3| 3| 4| 4| L | | 2| 8| 5| 6| 8| 2| 8| 9| 7| 0| 3| 4| 6| 7| 0| 4| 5| 7| 1| 6| 2| 3| 9| 2| 9| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + + + + + M + + + + + I + + + + + +| 43 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cystadenoma | X | 1 | Luteoma | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granular Cell Tumor Benign | | 1 | Polyp Stromal | X X X| 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | __________________________________________________________________________|____________| Lymph Node | | 7 | Pancreatic, Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M + + M + M M M M + + + + M + + M M M +| 29 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + M + + + + M +| 43 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + I + + + + + + + + + + +| 47 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + M M + + + + M + M M + M M + + M + + M + M + +| 31 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | __________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + + + + + + + + + M +| 45 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Sarcoma, | | | Multiple | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 0| 0| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 0| 0| 0| 1| 2| 3| 3| 3| 4| 4| L | | 2| 8| 5| 6| 8| 2| 8| 9| 7| 0| 3| 4| 6| 7| 0| 4| 5| 7| 1| 6| 2| 3| 9| 2| 9| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skeletal Muscle | + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pleura | | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 3 | Adenoma | X | 1 | Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Sarcoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X X X| 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 9| 2| 5| 9| 1| 7| 0| 0| 0| 0| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 2| 7| 1| 8| 0| 2| 6| 7| 8| 8| 4| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 62.5 PPB | 4| 0| 4| 0| 1| 4| 4| 3| 2| 1| 1| 0| 2| 0| 1| 1| 1| 1| 1| 2| 2| 3| 3| 4| 4| | 5| 7| 1| 6| 7| 9| 2| 1| 9| 2| 5| 9| 1| 1| 0| 1| 4| 8| 9| 2| 5| 2| 4| 0| 7| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + A + + M + + M + A + + + + + + + + + + + I| __________________________________________________________________________| Intestine Large, Colon | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + A + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + A + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + A + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | A + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X | __________________________________________________________________________| Mesentery | + + + + + | __________________________________________________________________________| Pancreas | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | Capsule, Carcinoma | | __________________________________________________________________________| Adrenal Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + A M M M M + M M M M M M M + M M + M + M +| __________________________________________________________________________| Pituitary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | A + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M A + + + + M + + M + + + + + + + + M M + +| __________________________________________________________________________| Ovary | A + + + A + + + + + + + + + + + + + I + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 9| 2| 5| 9| 1| 7| 0| 0| 0| 0| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 2| 7| 1| 8| 0| 2| 6| 7| 8| 8| 4| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 62.5 PPB | 4| 0| 4| 0| 1| 4| 4| 3| 2| 1| 1| 0| 2| 0| 1| 1| 1| 1| 1| 2| 2| 3| 3| 4| 4| | 5| 7| 1| 6| 7| 9| 2| 1| 9| 2| 5| 9| 1| 1| 0| 1| 4| 8| 9| 2| 5| 2| 4| 0| 7| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cystadenoma | X | __________________________________________________________________________| Uterus | A + + + A + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | Hemangioma | | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | A + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X | __________________________________________________________________________| Lymph Node | + + + | __________________________________________________________________________| Lymph Node, Bronchial | + M M + A + M + M + + M + M + + + + + M + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + M + + A M + + + + + + M + M + + + + + + + M + M| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node, Mesenteric | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | A + M + A + M + + + + + + M + + + M + + M + M + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Spleen | A + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | __________________________________________________________________________| Thymus | A + + + A M + + + + + + M + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Skeletal Muscle | + | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + A + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X| Alveolar/Bronchiolar Adenoma, | | Multiple | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 9| 2| 5| 9| 1| 7| 0| 0| 0| 0| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 2| 7| 1| 8| 0| 2| 6| 7| 8| 8| 4| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 62.5 PPB | 4| 0| 4| 0| 1| 4| 4| 3| 2| 1| 1| 0| 2| 0| 1| 1| 1| 1| 1| 2| 2| 3| 3| 4| 4| | 5| 7| 1| 6| 7| 9| 2| 1| 9| 2| 5| 9| 1| 1| 0| 1| 4| 8| 9| 2| 5| 2| 4| 0| 7| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Nose | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pleura | + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Trachea | A + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | A + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 62.5 PPB | 4| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 4| 5| 0| 0| 1| 2| 2| 2| 3| 3| 3| 4| 4| L | | 8| 3| 5| 8| 3| 3| 7| 8| 0| 5| 7| 9| 3| 0| 2| 4| 6| 0| 4| 6| 3| 6| 8| 4| 6| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + M M + + + + + + + + + + + + M +| 41 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | X | 2 | Hepatocellular Carcinoma | X X | 6 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X X | 11 | __________________________________________________________________________|____________| Mesentery | + | 6 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Capsule, Adenoma | | 1 | Capsule, Carcinoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M M + M M M + M + M + M M M + M + M M M +| 15 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X | 16 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 62.5 PPB | 4| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 4| 5| 0| 0| 1| 2| 2| 2| 3| 3| 3| 4| 4| L | | 8| 3| 5| 8| 3| 3| 7| 8| 0| 5| 7| 9| 3| 0| 2| 4| 6| 0| 4| 6| 3| 6| 8| 4| 6| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + M + + + + + + + + M + + + + +| 42 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Cystadenoma | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X | 1 | Carcinoma | | 1 | Hemangioma | X | 1 | Polyp Stromal | X X X| 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 3 | __________________________________________________________________________|____________| Lymph Node | + | 4 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M + + + M + M + M + + + + M + M M M + + + + + M| 32 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + M + + + + M + + + + + + + + +| 40 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + M M + M M M M M + M M + M M + M M M M M M| 23 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | X | 3 | __________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Spinal Cord | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 62.5 PPB | 4| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 4| 5| 0| 0| 1| 2| 2| 2| 3| 3| 3| 4| 4| L | | 8| 3| 5| 8| 3| 3| 7| 8| 0| 5| 7| 9| 3| 0| 2| 4| 6| 0| 4| 6| 3| 6| 8| 4| 6| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | | 3 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X X | 4 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 5 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pleura | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 2| 7| 3| 4| 6| 7| 7| 8| 8| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 4| 0| 5| 0| 6| 2| 2| 6| 7| 2| 4| 5| 9| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 125 PPB | 4| 3| 0| 2| 0| 2| 1| 3| 4| 3| 3| 1| 4| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| | 8| 3| 8| 2| 7| 0| 9| 6| 9| 0| 1| 8| 3| 5| 4| 3| 1| 2| 3| 4| 6| 1| 3| 4| 9| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + A A + A + + + + + + A M + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Intestine Large, Colon | + A + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + I + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A A + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + A + A + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | __________________________________________________________________________| Intestine Small, Ileum | + A + A + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X | Hepatocholangiocarcinoma | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Mesentery | + + + + | Carcinoma, Metastatic, Uterus | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + A + A + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Squamous Cell Papilloma | X| __________________________________________________________________________| Stomach, Glandular | + + + A + A + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | Capsule, Carcinoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + A + + + + + + + I + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | M M + M + M + M M + + + + M + + + + + + M + M M M| __________________________________________________________________________| Pituitary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X| Pars Intermedia, Adenoma | X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 2| 7| 3| 4| 6| 7| 7| 8| 8| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 4| 0| 5| 0| 6| 2| 2| 6| 7| 2| 4| 5| 9| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 125 PPB | 4| 3| 0| 2| 0| 2| 1| 3| 4| 3| 3| 1| 4| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| | 8| 3| 8| 2| 7| 0| 9| 6| 9| 0| 1| 8| 3| 5| 4| 3| 1| 2| 3| 4| 6| 1| 3| 4| 9| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + | Carcinoma, Metastatic, Uterus | X | Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + M + + M + + + + + + + + M +| __________________________________________________________________________| Ovary | + + + + + A + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | Cystadenoma | | Hemangiosarcoma | X | Histiocytic Sarcoma | X | Bilateral, Tubulostromal Adenoma | | __________________________________________________________________________| Uterus | + + + + + A + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Leiomyoma | X | Polyp Stromal | X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + + + | __________________________________________________________________________| Lymph Node, Bronchial | + + + A + + + M + + + + + + M + M + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node, Mandibular | + + M + M + + M + + + + + + M + + + + + + + M + M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + A + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M M + M M + + + + + + + + + + M + + + + + + M + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Spleen | + + + A + A + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Thymus | M + M + M M + M + + + + M + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X X X | Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 2| 7| 3| 4| 6| 7| 7| 8| 8| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 4| 0| 5| 0| 6| 2| 2| 6| 7| 2| 4| 5| 9| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 125 PPB | 4| 3| 0| 2| 0| 2| 1| 3| 4| 3| 3| 1| 4| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| | 8| 3| 8| 2| 7| 0| 9| 6| 9| 0| 1| 8| 3| 5| 4| 3| 1| 2| 3| 4| 6| 1| 3| 4| 9| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X X| Carcinoma, Metastatic, Uterus | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pleura | + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Urinary Bladder | + + + A + A + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 125 PPB | 3| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 1| 2| 2| 2| 2| 3| 4| 4| 4| L | | 2| 1| 2| 6| 9| 0| 7| 5| 7| 8| 9| 0| 2| 5| 7| 0| 5| 5| 6| 7| 8| 4| 1| 4| 6| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + M + M + + + + + + + + + + + + + + + +| 43 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Carcinoma, Metastatic, Uterus | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X | 5 | Hepatocellular Adenoma | X X X | 7 | Hepatocholangiocarcinoma | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Mesentery | + | 5 | Carcinoma, Metastatic, Uterus | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Uterus | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Squamous Cell Carcinoma | X| 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Uterus | | 1 | Capsule, Carcinoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 125 PPB | 3| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 1| 2| 2| 2| 2| 3| 4| 4| 4| L | | 2| 1| 2| 6| 9| 0| 7| 5| 7| 8| 9| 0| 2| 5| 7| 0| 5| 5| 6| 7| 8| 4| 1| 4| 6| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + M M M + + + + M + + M + + M M M + M + + + M + +| 29 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X X X | 20 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 2 | Carcinoma, Metastatic, Uterus | | 1 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Uterus | | 1 | Cystadenoma | X| 1 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | Bilateral, Tubulostromal Adenoma | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X | 2 | Leiomyoma | X | 2 | Polyp Stromal | X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + M + M M + + + M + + M M + M M M + +| 37 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + + M + + M + + M + + + + + M + + + +| 39 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + M + + + + + +| 46 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + M M M M M + + M + + M M + + M + + +| 34 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 125 PPB | 3| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 1| 2| 2| 2| 2| 3| 4| 4| 4| L | | 2| 1| 2| 6| 9| 0| 7| 5| 7| 8| 9| 0| 2| 5| 7| 0| 5| 5| 6| 7| 8| 4| 1| 4| 6| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + + M + + + + M + + + + + + M + + + M + + +| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | | 3 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | X X X | 5 | Carcinoma, Metastatic, Uterus | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pleura | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocholangiocarcinoma, Metastatic,| | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 125 PPB | 3| 0| 0| 0| 0| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 1| 2| 2| 2| 2| 3| 4| 4| 4| L | | 2| 1| 2| 6| 9| 0| 7| 5| 7| 8| 9| 0| 2| 5| 7| 0| 5| 5| 6| 7| 8| 4| 1| 4| 6| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Liver | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Carcinoma, Metastatic, Uterus | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X| 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 9| 0| 4| 5| 6| 8| 1| 3| 6| 8| 8| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 2| 2| 2| 0| 8| 6| 1| 0| 5| 6| 1| 7| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPB | 2| 3| 2| 4| 2| 0| 2| 0| 3| 2| 3| 3| 1| 4| 3| 2| 2| 3| 0| 1| 1| 2| 3| 4| 0| | 3| 8| 7| 2| 9| 8| 5| 6| 5| 2| 2| 9| 6| 6| 1| 0| 8| 3| 9| 2| 7| 6| 6| 0| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + + + + I A M A + + + A + + M + + + + + + +| Adenoma | X | __________________________________________________________________________| Intestine Large, Colon | A + + + + + + + A + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | A + + + + + + + A + A + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + A + A + + + A + + + + + + + + + +| Leiomyosarcoma | | __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + A + + + + + + + + + + + + + + + +| Polyp Adenomatous | X | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + A + A + + A A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + A + A + + + A + + + + + + + + + +| Polyp Adenomatous | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X | Ito Cell Tumor Malignant | | __________________________________________________________________________| Mesentery | + + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | A + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | A + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + M + M M M + + M + M M + M + M + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 9| 0| 4| 5| 6| 8| 1| 3| 6| 8| 8| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 2| 2| 2| 0| 8| 6| 1| 0| 5| 6| 1| 7| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPB | 2| 3| 2| 4| 2| 0| 2| 0| 3| 2| 3| 3| 1| 4| 3| 2| 2| 3| 0| 1| 1| 2| 3| 4| 0| | 3| 8| 7| 2| 9| 8| 5| 6| 5| 2| 2| 9| 6| 6| 1| 0| 8| 3| 9| 2| 7| 6| 6| 0| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Clitoral Gland | M M + + + M + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | __________________________________________________________________________| Uterus | + + + + + + + + A + + + + + + + + + + + + + + + +| Carcinoma | | Leiomyoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + + + A M + + M + M + + + + + + M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + M M + + + + + + + + M + + + M +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + A + + + + + + M + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node, Mediastinal | M M + + + + + + M + + + + M M + + + + M + M + + +| __________________________________________________________________________| Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Thymus | + + + M + + + + A + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Sarcoma | X X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Leiomyosarcoma, Metastatic, | | Intestine Large, Cecum | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 9| 0| 4| 5| 6| 8| 1| 3| 6| 8| 8| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 2| 2| 2| 0| 8| 6| 1| 0| 5| 6| 1| 7| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPB | 2| 3| 2| 4| 2| 0| 2| 0| 3| 2| 3| 3| 1| 4| 3| 2| 2| 3| 0| 1| 1| 2| 3| 4| 0| | 3| 8| 7| 2| 9| 8| 5| 6| 5| 2| 2| 9| 6| 6| 1| 0| 8| 3| 9| 2| 7| 6| 6| 0| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | A + + + + + + + A + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X X X X X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 250 PPB | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 0| 1| 1| 2| 3| 4| 4| 4| 4| 5| L | | 2| 3| 5| 7| 0| 1| 3| 5| 8| 1| 0| 7| 1| 8| 9| 4| 4| 9| 4| 4| 3| 4| 5| 7| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + M + + + + + + M + + + + + +| 41 | Adenoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + I + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Leiomyosarcoma | X | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X| 3 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X | 3 | Ito Cell Tumor Malignant | X | 1 | __________________________________________________________________________|____________| Mesentery | +| 6 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + I + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Benign | X X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M M + M + M + + M + + M + + M M M + + M + +| 28 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X| 16 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X X | 3 | Follicular Cell, Carcinoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 250 PPB | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 0| 1| 1| 2| 3| 4| 4| 4| 4| 5| L | | 2| 3| 5| 7| 0| 1| 3| 5| 8| 1| 0| 7| 1| 8| 9| 4| 4| 9| 4| 4| 3| 4| 5| 7| 0| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + M + + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | X X | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X X | 2 | Leiomyoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M + + + M M + + M + M + + + + + M M M| 36 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + I M M + M + + + + + + + M + + M| 38 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + I +| 46 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + + M + + + + M + M + + + + + + M M + + +| 37 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Sarcoma | X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + I| 48 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 2 | Alveolar/Bronchiolar Carcinoma | X X | 2 | Hepatocellular Carcinoma, Metastatic,| | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 250 PPB | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 0| 1| 1| 2| 3| 4| 4| 4| 4| 5| L | | 2| 3| 5| 7| 0| 1| 3| 5| 8| 1| 0| 7| 1| 8| 9| 4| 4| 9| 4| 4| 3| 4| 5| 7| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Liver | | 2 | Leiomyosarcoma, Metastatic, | | | Intestine Large, Cecum | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 2 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Urinary Bladder | + + + I + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 9| 1| 3| 3| 7| 0| 1| 2| 7| 7| 8| 8| 8| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| | 9| 4| 8| 6| 2| 4| 3| 2| 6| 6| 0| 5| 4| 4| 8| 2| 2| 6| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 3| 0| 0| 1| 2| 1| 1| 1| 1| 1| 3| 2| 3| 4| 1| 2| 3| 3| 2| 0| 1| 1| 2| 2| 2| | 2| 5| 8| 7| 3| 5| 3| 9| 6| 1| 7| 4| 1| 3| 4| 2| 5| 8| 0| 2| 0| 2| 5| 6| 8| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + A + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + A + + + M + + A A A + A A + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + A A + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + A + + + I + + A A A + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + A + A + A + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + A A A + A A + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + A A A + A A + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + A A A + A A + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + A + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X X X X X X X X | Hepatocellular Adenoma | X X X X X X X | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + M + + + + + + + A + + A + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + A + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + A + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + A + + + + + + A A + + A + + + + + + + + + + +| __________________________________________________________________________| Tooth | + + + + + | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + A + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + A + + + + + + + A + + A + + + + + + + + + + +| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + A + + + + + + + A + + A + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + M + + + + + + + A + + A + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + A M + M M + + + A M M M M + M + M M M M M M M| __________________________________________________________________________| Pituitary Gland | + + I + + + + + + + A + + + + + + I + + + + + + +| Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + A + + + + + + + A + + + + + + + + + + + + + +| Bilateral, Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 9| 1| 3| 3| 7| 0| 1| 2| 7| 7| 8| 8| 8| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| | 9| 4| 8| 6| 2| 4| 3| 2| 6| 6| 0| 5| 4| 4| 8| 2| 2| 6| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 3| 0| 0| 1| 2| 1| 1| 1| 1| 1| 3| 2| 3| 4| 1| 2| 3| 3| 2| 0| 1| 1| 2| 2| 2| | 2| 5| 8| 7| 3| 5| 3| 9| 6| 1| 7| 4| 1| 3| 4| 2| 5| 8| 0| 2| 0| 2| 5| 6| 8| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Coagulating Gland | + | __________________________________________________________________________| Epididymis | + + A + + + + + + + A + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Preputial Gland | + + A + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + A + + + + + + + A + + A + + + + + + + + + + +| __________________________________________________________________________| Testes | + + A + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + A + + + + + + + A + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | + M A + + M + M + M + M + + + + M M M + + + + + M| Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node, Mandibular | + + A + + + + M M + + + M + + + M M M + + M + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + A + + + + + + + A + + M + + M + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + M A + + + + M + M + + + M M + + M M M M M + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Spleen | + + M + + + + + + + + + + A + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Thymus | + + A + M + + M + + A M M A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + A + + + + + + + A + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + A + + + + + + + A + + A + + + + + + + + + + +| __________________________________________________________________________| Lung | + + A + + + + + + + A + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X| Alveolar/Bronchiolar Carcinoma | X X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X X X X | Histiocytic Sarcoma | X X | __________________________________________________________________________| Nose | + + A + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 9| 1| 3| 3| 7| 0| 1| 2| 7| 7| 8| 8| 8| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| | 9| 4| 8| 6| 2| 4| 3| 2| 6| 6| 0| 5| 4| 4| 8| 2| 2| 6| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 3| 0| 0| 1| 2| 1| 1| 1| 1| 1| 3| 2| 3| 4| 1| 2| 3| 3| 2| 0| 1| 1| 2| 2| 2| | 2| 5| 8| 7| 3| 5| 3| 9| 6| 1| 7| 4| 1| 3| 4| 2| 5| 8| 0| 2| 0| 2| 5| 6| 8| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + A + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + A + + + + + + + A + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Urinary Bladder | + + A + + + + + + + A + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X X | Lymphoma Malignant | X X X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 2| 2| 3| 4| 5| 0| 0| 0| 0| 1| 4| 4| L | | 9| 0| 3| 4| 9| 1| 4| 6| 7| 8| 9| 3| 4| 1| 7| 6| 5| 0| 1| 6| 7| 9| 8| 0| 2| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + I + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 2 | Hepatocellular Carcinoma | X X X | 15 | Hepatocellular Adenoma | X X X X X X X X| 15 | Hepatocellular Adenoma, Multiple | X X X X | 4 | Histiocytic Sarcoma | | 3 | __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Tooth | + + + + + + + + | 13 | Odontoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Capsule, Adenoma | X X | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M + M + + + M + + + + M + M + M M + + + M M| 21 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +| 46 | Pars Distalis, Adenoma | X | 1 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Bilateral, Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 2| 2| 3| 4| 5| 0| 0| 0| 0| 1| 4| 4| L | | 9| 0| 3| 4| 9| 1| 4| 6| 7| 8| 9| 3| 4| 1| 7| 6| 5| 0| 1| 6| 7| 9| 8| 0| 2| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 1 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M M + + + M M + + + + + + + + + + + + + + M M| 34 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + M + + M M + + + + + + + M M +| 36 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + M M + M + M + M + + + + M M M + + + + + + + M| 29 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + + + + M M + + + + + M + M + + + + + + + + + + +| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 2| 2| 3| 4| 5| 0| 0| 0| 0| 1| 4| 4| L | | 9| 0| 3| 4| 9| 1| 4| 6| 7| 8| 9| 3| 4| 1| 7| 6| 5| 0| 1| 6| 7| 9| 8| 0| 2| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar/Bronchiolar Adenoma | X X X X X | 8 | Alveolar/Bronchiolar Carcinoma | X X X X | 9 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 6 | Histiocytic Sarcoma | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | Adenoma | X | 3 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 3 | Lymphoma Malignant | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 0| 2| 7| 1| 2| 2| 3| 5| 7| 8| 9| 1| 4| 4| 4| 6| 8| 9| 0| 0| 1| 2| 3| 3| | 4| 2| 0| 6| 7| 4| 4| 9| 1| 3| 8| 8| 6| 0| 0| 7| 6| 5| 8| 6| 7| 8| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 62.5 PPB | 1| 0| 4| 4| 4| 3| 3| 2| 2| 0| 1| 4| 2| 2| 2| 2| 0| 0| 1| 0| 1| 0| 5| 1| 1| | 7| 5| 4| 8| 3| 1| 3| 0| 7| 7| 6| 9| 6| 1| 2| 3| 6| 2| 0| 3| 4| 4| 0| 1| 2| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + M A + + A + + A A A + + A + M A + + M| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + A + + A + + + A + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + A + + A + + + A + + + A + + A + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + A + + A + + + A A + + A + + A + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + A + + A + + A A A + + A + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + A + + A A A + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + + A + + + A A + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | X X X X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | | Hepatocholangiocarcinoma | X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| Squamous Cell Carcinoma | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + A + + + A + + + A + + + + + +| __________________________________________________________________________| Tooth | + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + A + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + M + + M M M M + M + + + M M M + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + A + + + A + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 0| 2| 7| 1| 2| 2| 3| 5| 7| 8| 9| 1| 4| 4| 4| 6| 8| 9| 0| 0| 1| 2| 3| 3| | 4| 2| 0| 6| 7| 4| 4| 9| 1| 3| 8| 8| 6| 0| 0| 7| 6| 5| 8| 6| 7| 8| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 62.5 PPB | 1| 0| 4| 4| 4| 3| 3| 2| 2| 0| 1| 4| 2| 2| 2| 2| 0| 0| 1| 0| 1| 0| 5| 1| 1| | 7| 5| 4| 8| 3| 1| 3| 0| 7| 7| 6| 9| 6| 1| 2| 3| 6| 2| 0| 3| 4| 4| 0| 1| 2| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Squamous Cell Carcinoma | | __________________________________________________________________________| Prostate | + + + M + + + + + I + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + A A + + A + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + + | __________________________________________________________________________| Lymph Node, Bronchial | + + M M + M + + + + M + M + + + M M M M M M M M M| __________________________________________________________________________| Lymph Node, Mandibular | + M M M M + + + + + M + M M A + + + + M + A M M M| __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + A + + + A + + + + + M + + M +| __________________________________________________________________________| Lymph Node, Mediastinal | + M M + + M M + M + + + + + M + M + M M M M I M +| __________________________________________________________________________| Spleen | + + + + + + + A + + + + + + A + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Thymus | + + + M + + M + + + + + M M A + + M M M M A M M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X X X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 0| 2| 7| 1| 2| 2| 3| 5| 7| 8| 9| 1| 4| 4| 4| 6| 8| 9| 0| 0| 1| 2| 3| 3| | 4| 2| 0| 6| 7| 4| 4| 9| 1| 3| 8| 8| 6| 0| 0| 7| 6| 5| 8| 6| 7| 8| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 62.5 PPB | 1| 0| 4| 4| 4| 3| 3| 2| 2| 0| 1| 4| 2| 2| 2| 2| 0| 0| 1| 0| 1| 0| 5| 1| 1| | 7| 5| 4| 8| 3| 1| 3| 0| 7| 7| 6| 9| 6| 1| 2| 3| 6| 2| 0| 3| 4| 4| 0| 1| 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Pleura | + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + A + + + A + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 62.5 PPB | 1| 1| 1| 3| 3| 4| 4| 0| 0| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 3| 3| L | | 3| 8| 9| 0| 5| 0| 5| 1| 8| 4| 5| 8| 9| 4| 6| 7| 8| 1| 2| 6| 7| 9| 5| 2| 9| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | M M M + + + + + + + + + M + + + + + + + + + + + +| 36 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X | 9 | Hepatocellular Carcinoma, Multiple | X X | 6 | Hepatocellular Adenoma | X X X X| 7 | Hepatocellular Adenoma, Multiple | X X X | 3 | Hepatocholangiocarcinoma | | 1 | __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + +| 17 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + M M + + + + M + M + + + + + M M M + M M M| 27 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | X X X | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 62.5 PPB | 1| 1| 1| 3| 3| 4| 4| 0| 0| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 3| 3| L | | 3| 8| 9| 0| 5| 0| 5| 1| 8| 4| 5| 8| 9| 4| 6| 7| 8| 1| 2| 6| 7| 9| 5| 2| 9| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + M + + M + M + + M + + + + M + M + + M + + +| 28 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M M M + M M + I M + M M M M M M + + M + + + +| 22 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M M + + M + + + + + M M + M + M + + + M + M +| 27 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Thymus | M + + M + + + + + + + + + + + + M + + + + + M + +| 34 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 62.5 PPB | 1| 1| 1| 3| 3| 4| 4| 0| 0| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 3| 3| L | | 3| 8| 9| 0| 5| 0| 5| 1| 8| 4| 5| 8| 9| 4| 6| 7| 8| 1| 2| 6| 7| 9| 5| 2| 9| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X X | 10 | Alveolar/Bronchiolar Carcinoma | X X | 6 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pleura | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + + | 5 | Adenoma | X X X | 3 | Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 2| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 7| 9| 0| 1| 1| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 0| 2| 4| 6| 9| 5| 2| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 125 PPB | 1| 0| 2| 1| 0| 3| 2| 4| 4| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 4| 4| 5| | 2| 9| 7| 4| 7| 8| 0| 5| 1| 6| 2| 4| 0| 8| 9| 6| 8| 0| 2| 4| 5| 9| 3| 7| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + A A + M M A + A M + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Mesentery | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + I + A + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + A + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X | Hepatocellular Carcinoma | X X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X X X | Hepatocellular Adenoma, Multiple | X X | __________________________________________________________________________| Mesentery | + + +| Sarcoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Mesentery | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Mesentery | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Mesentery | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + M M M + + + + + I + + + M M M M M M I| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 2| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 7| 9| 0| 1| 1| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 0| 2| 4| 6| 9| 5| 2| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 125 PPB | 1| 0| 2| 1| 0| 3| 2| 4| 4| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 4| 4| 5| | 2| 9| 7| 4| 7| 8| 0| 5| 1| 6| 2| 4| 0| 8| 9| 6| 8| 0| 2| 4| 5| 9| 3| 7| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Benign | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant | | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + M M M + M + + + + + + + + M M + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Lymph Node, Mandibular | + M M M + + + M M + + + + + M M + + M M M M M + M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + M + M + + + + + + + + + + +| Sarcoma, Metastatic, Mesentery | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + M M + M + M + + + + M + M + M + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Thymus | + + + + + M M + + + + + + + M + + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Carcinoma | X X X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 2| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 7| 9| 0| 1| 1| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 0| 2| 4| 6| 9| 5| 2| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 125 PPB | 1| 0| 2| 1| 0| 3| 2| 4| 4| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 4| 4| 5| | 2| 9| 7| 4| 7| 8| 0| 5| 1| 6| 2| 4| 0| 8| 9| 6| 8| 0| 2| 4| 5| 9| 3| 7| 0| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Mast Cell Tumor Malignant, | | Metastatic, Bone Marrow | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 125 PPB | 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 1| 1| 2| 3| 4| L | | 1| 3| 5| 6| 8| 1| 3| 7| 1| 2| 3| 4| 9| 1| 6| 7| 0| 2| 4| 9| 5| 6| 5| 3| 8| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + M + + M + + +| 41 | Sarcoma, Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + I + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 3 | Hepatocellular Carcinoma | X X X X | 10 | Hepatocellular Carcinoma, Multiple | X | 2 | Hepatocellular Adenoma | X X X X X X X X | 16 | Hepatocellular Adenoma, Multiple | X X | 4 | __________________________________________________________________________|____________| Mesentery | | 3 | Sarcoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tooth | + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Mesentery | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Adenoma | X X | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + + + + M M M + M + + + + M M + + M + M + M| 27 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 125 PPB | 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 1| 1| 2| 3| 4| L | | 1| 3| 5| 6| 8| 1| 3| 7| 1| 2| 3| 4| 9| 1| 6| 7| 0| 2| 4| 9| 5| 6| 5| 3| 8| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granular Cell Tumor Benign | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mast Cell Tumor Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + M M + M + M M + + + + + + M + M + + +| 35 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + M + + + M + + + + + M M + + M + + + + + M +| 30 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Sarcoma, Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M M + + M M + + + + M + + + + + + + + M M + +| 33 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + M + + + + + + M + + + + M + + + + + + + + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 125 PPB | 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 1| 1| 2| 3| 4| L | | 1| 3| 5| 6| 8| 1| 3| 7| 1| 2| 3| 4| 9| 1| 6| 7| 0| 2| 4| 9| 5| 6| 5| 3| 8| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X | 9 | Alveolar/Bronchiolar Carcinoma | X X X| 7 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X | 6 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 2 | Adenoma | X | 2 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Mast Cell Tumor Malignant, | | | Metastatic, Bone Marrow | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 0| 5| 8| 2| 4| 5| 6| 7| 7| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 4| 8| 9| 8| 1| 1| 3| 2| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 250 PPB | 2| 3| 1| 3| 3| 2| 0| 2| 4| 1| 2| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 3| 3| | 4| 9| 4| 2| 0| 9| 5| 5| 1| 0| 7| 5| 1| 7| 8| 9| 1| 2| 3| 6| 9| 0| 2| 1| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + A A A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + A A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + A A + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + A A + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + A A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | | Hepatocholangiocarcinoma | X | __________________________________________________________________________| Mesentery | + + +| __________________________________________________________________________| Pancreas | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + A M M + M + + M M + + M + + M M + M + M M| __________________________________________________________________________| Pituitary Gland | A + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + A + + + + + + + + + + + + + I + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 0| 5| 8| 2| 4| 5| 6| 7| 7| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 4| 8| 9| 8| 1| 1| 3| 2| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 250 PPB | 2| 3| 1| 3| 3| 2| 0| 2| 4| 1| 2| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 3| 3| | 4| 9| 4| 2| 0| 9| 5| 5| 1| 0| 7| 5| 1| 7| 8| 9| 1| 2| 3| 6| 9| 0| 2| 1| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Bronchial | + + + M M + M M + M M + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + M M + A + + M M + + + M + + + M + + + M + M M M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + A + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + M M + A M M + + + + M M M + + + M M M M + + + +| __________________________________________________________________________| Spleen | A + + + A + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Thymus | + + + + A M M M + + + + + + + M + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X X X X X| Alveolar/Bronchiolar Carcinoma, | | Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pleura | + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Trachea | + + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 _____________________________________________________________________________________________________________________ | 3| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 0| 5| 8| 2| 4| 5| 6| 7| 7| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 4| 8| 9| 8| 1| 1| 3| 2| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 250 PPB | 2| 3| 1| 3| 3| 2| 0| 2| 4| 1| 2| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 3| 3| | 4| 9| 4| 2| 0| 9| 5| 5| 1| 0| 7| 5| 1| 7| 8| 9| 1| 2| 3| 6| 9| 0| 2| 1| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Harderian Gland | | Adenoma | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | A + + A A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 250 PPB | 3| 3| 4| 4| 0| 0| 0| 0| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 1| 4| 4| L | | 7| 8| 3| 7| 2| 3| 4| 6| 8| 1| 3| 6| 8| 3| 4| 6| 2| 4| 5| 6| 8| 0| 7| 0| 9| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 2 | Hepatocellular Carcinoma | X X X X X | 10 | Hepatocellular Carcinoma, Multiple | | 2 | Hepatocellular Adenoma | X X X X | 9 | Hepatocellular Adenoma, Multiple | X X| 2 | Hepatocholangiocarcinoma | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 5 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + | 19 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Capsule, Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M + + + M + + + + M + + + + M M M + + M + M| 27 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 250 PPB | 3| 3| 4| 4| 0| 0| 0| 0| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 1| 4| 4| L | | 7| 8| 3| 7| 2| 3| 4| 6| 8| 1| 3| 6| 8| 3| 4| 6| 2| 4| 5| 6| 8| 0| 7| 0| 9| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + M + M + + + +| 47 | __________________________________________________________________________|____________| Prostate | + + + + + I + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M M M + + M + + + + + + + + M + + M + M + +| 37 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + M M + + + + M + M + + + + M + + + +| 33 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + I + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M M M + + + + + + M + + M M + M + + M + +| 30 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + I + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X | 6 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X | 6 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically NTP Experiment-Test: 05184-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC GLUTARALDEHYDE Date: 07/13/98 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 250 PPB | 3| 3| 4| 4| 0| 0| 0| 0| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 1| 4| 4| L | | 7| 8| 3| 7| 2| 3| 4| 6| 8| 1| 3| 6| 8| 3| 4| 6| 2| 4| 5| 6| 8| 0| 7| 0| 9| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 4 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pleura | | 2 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | Adenoma | X | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------