TDMS Study 05185-04 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ISOBUTYL NITRITE (IBN)
NTP Experiment-Test: 05185-04 Report: PEIRPT05
Study Type: CHRONIC Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
Facility: I. I. T. Research Institute
Chemical CAS #: 542-56-3
Lock Date: 08/20/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 9 9 9 10
Early Deaths
Natural Death 16 6 8 10
Moribund Sacrifice 3 3 6 2
Accidently Killed 1
Survivors
Terminal Sacrifice 32 42 36 37
Other 1
Animals Examined Microscopically 60 60 59 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (58) (59) (57)
Squamous Cell Carcinoma 1 (2%)
Gallbladder (55) (55) (54) (51)
Intestine Large, Colon (60) (60) (59) (56)
Intestine Large, Rectum (57) (60) (59) (57)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Intestine Large, Cecum (57) (58) (59) (55)
Intestine Small, Duodenum (51) (59) (58) (52)
Intestine Small, Jejunum (53) (59) (56) (55)
Intestine Small, Ileum (53) (57) (59) (54)
Liver (60) (60) (59) (60)
Hepatocellular Carcinoma 3 (5%) 5 (8%) 2 (3%) 5 (8%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 7 (12%) 10 (17%) 2 (3%) 4 (7%)
Hepatocellular Adenoma, Multiple 5 (8%) 2 (3%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 2 (3%) 1 (2%) 1 (2%)
Mesentery (7) (4) (3) (2)
Hepatocellular Carcinoma, Metastatic, Liver 1 (14%)
Pancreas (60) (60) (59) (60)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Salivary Glands (60) (60) (59) (60)
Stomach, Forestomach (60) (60) (59) (59)
Stomach, Glandular (60) (60) (59) (59)
Tooth (1) (1) (1)
Odontoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (59) (60)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (60) (59) (59)
Adrenal Medulla (55) (58) (54) (57)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 2 (4%) 2 (4%)
Islets, Pancreatic (2) (2) (3) (3)
Adenoma 1 (50%)
Pituitary Gland (56) (56) (59) (57)
Pars Distalis, Adenoma 12 (21%) 19 (34%) 18 (31%) 13 (23%)
Pars Intermedia, Adenoma 2 (4%) 2 (4%)
Thyroid Gland (60) (60) (59) (60)
Follicular Cell, Adenoma 4 (7%) 3 (5%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (58) (59) (55) (59)
Cystadenoma 1 (2%) 2 (4%) 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Oviduct (1)
Uterus (60) (60) (58) (59)
Deciduoma NOS 1 (2%)
Hemangioma 1 (2%)
Histiocytic Sarcoma 2 (3%) 2 (3%) 1 (2%)
Leiomyosarcoma 1 (2%) 1 (2%)
Myxoma 1 (2%)
Polyp Stromal 3 (5%) 2 (3%) 1 (2%)
Sarcoma Stromal 1 (2%)
Vagina (1) (1) (2)
Histiocytic Sarcoma 1 (100%)
Squamous Cell Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (59) (60)
Lymph Node (4) (5) (8) (6)
Inguinal, Histiocytic Sarcoma 1 (25%)
Lumbar, Histiocytic Sarcoma 1 (25%)
Pancreatic, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (25%)
Renal, Histiocytic Sarcoma 1 (25%)
Lymph Node, Bronchial (28) (42) (40) (38)
Lymph Node, Mandibular (58) (57) (57) (55)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (60) (59) (58) (55)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (58) (51) (52) (53)
Histiocytic Sarcoma 1 (2%)
Spleen (60) (60) (59) (59)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (56) (56) (57) (51)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (60) (59) (60)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%)
Skin (60) (60) (59) (60)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (59) (60)
Hemangioma 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Skeletal Muscle (3) (1) (1)
Hemangiosarcoma 1 (33%)
Osteosarcoma 1 (33%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (59) (60)
Adenoma 1 (2%)
Alveolar/Bronchiolar Adenoma 4 (7%) 13 (22%) 7 (12%) 17 (28%)
Alveolar/Bronchiolar Adenoma, Multiple 3 (5%) 1 (2%) 2 (3%)
Alveolar/Bronchiolar Carcinoma 2 (3%) 2 (3%) 2 (3%) 2 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%) 2 (3%) 3 (5%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Mediastinum, Hepatocellular Carcinoma,
Metastatic, Liver 1 (2%)
Mediastinum, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (2%)
Nose (60) (60) (59) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (2) (2)
Adenoma 1 (100%) 1 (50%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59) (60)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Urinary Bladder (58) (59) (57) (57)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(59) *(60)
Histiocytic Sarcoma 2 (3%) 2 (3%) 2 (3%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%) 3 (5%)
Lymphoma Malignant Mixed 5 (8%) 4 (7%) 9 (15%) 6 (10%)
Lymphoma Malignant Undifferentiated Cell 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 38 48 39 42
Total Primary Neoplasms 55 77 63 71
Total Animals with Benign Neoplasms 28 38 31 35
Total Benign Neoplasms 35 55 43 50
Total Animals with Malignant Neoplasms 17 18 19 19
Total Malignant Neoplasms 20 21 20 21
Total Animals with Metastatic Neoplasms 3 2 2 3
Total Metastatic Neoplasm 10 3 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 7
Early Deaths
Natural Death 10 8 11 17
Accidently Killed 2 2
Moribund Sacrifice 1 7 4 4
Survivors
Terminal Sacrifice 37 35 35 30
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (52) (55) (56) (50)
Adenocarcinoma 1 (2%)
Adenocarcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Intestine Small, Ileum (55) (55) (53) (50)
Adenocarcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Liver (60) (60) (60) (60)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Cholangiocarcinoma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Hemangiosarcoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma 10 (17%) 6 (10%) 9 (15%) 9 (15%)
Hepatocellular Carcinoma, Multiple 3 (5%) 1 (2%) 2 (3%)
Hepatocellular Adenoma 11 (18%) 16 (27%) 17 (28%) 14 (23%)
Hepatocellular Adenoma, Multiple 5 (8%) 1 (2%) 2 (3%)
Mesentery (1) (5) (2)
Cholangiocarcinoma, Metastatic, Liver 1 (20%)
Hemangiosarcoma 1 (20%)
Pancreas (60) (59) (60) (56)
Salivary Glands (60) (60) (60) (60)
Stomach, Forestomach (59) (59) (59) (56)
Squamous Cell Carcinoma 1 (2%)
Tooth (3) (1) (1)
Odontoma 1 (33%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (59) (58) (58)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Subcapsular, Adenoma 1 (2%) 1 (2%)
Adrenal Medulla (59) (59) (58) (58)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Pheochromocytoma Benign 2 (3%) 1 (2%)
Islets, Pancreatic (5) (3) (9) (1)
Adenoma 2 (40%) 1 (33%) 2 (22%)
Pituitary Gland (56) (56) (54) (54)
Pars Distalis, Adenoma 1 (2%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (60) (60) (60) (60)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Bilateral, Follicular Cell, Adenoma 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 4 (7%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60) (60)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Seminal Vesicle (60) (60) (60) (60)
Testes (60) (60) (60) (60)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (59) (59)
Hemangiosarcoma 1 (2%)
Lymph Node (1) (5) (5) (5)
Inguinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (20%)
Inguinal, Cholangiocarcinoma, Metastatic,
Liver 1 (20%)
Lymph Node, Bronchial (33) (45) (26) (39)
Lymph Node, Mandibular (49) (59) (60) (55)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Lymph Node, Mesenteric (57) (57) (57) (56)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Lymph Node, Mediastinal (48) (47) (48) (46)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Spleen (60) (60) (59) (58)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Thymus (55) (56) (48) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (59) (59)
Subcutaneous Tissue, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant,
Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Mandible, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Rib, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Skeletal Muscle (1) (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Page 9
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont
Lung 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (60) (60) (59) (57)
Lung (60) (60) (59) (60)
Alveolar/Bronchiolar Adenoma 8 (13%) 11 (18%) 10 (17%) 12 (20%)
Alveolar/Bronchiolar Adenoma, Multiple 3 (5%) 3 (5%) 5 (8%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 5 (8%) 4 (7%) 4 (7%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 5 (8%) 6 (10%) 4 (7%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Mediastinum, Cholangiocarcinoma, Metastatic,
Liver 1 (2%)
Nose (60) (60) (60) (60)
Glands, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (5) (1) (3) (6)
Adenocarcinoma 1 (17%)
Adenoma 4 (80%) 1 (100%) 3 (100%) 5 (83%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (60) (58) (59) (57)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Page 10
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%) 3 (5%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05185-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOBUTYL NITRITE (IBN) Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 37.5 PPM 75 PPM 150 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 38 39 43 42
Total Primary Neoplasms 51 57 64 69
Total Animals with Benign Neoplasms 28 31 33 36
Total Benign Neoplasms 34 37 39 48
Total Animals with Malignant Neoplasms 17 19 22 17
Total Malignant Neoplasms 17 20 25 21
Total Animals with Metastatic Neoplasms 5 7 7 2
Total Metastatic Neoplasm 5 18 19 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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