TDMS Study 05185-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IITRI ISOBUTYL NITRITE (IBN) DATE: 05/20/95
EXPERIMENT: 05185 TEST: 04 TIME: 11:45:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01 ES 65143 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61052B
PATHOLOGIST: RICHARD LONG CAS: 542-56-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IITRI ISOBUTYL NITRITE (IBN) DATE: 05/20/95
EXPERIMENT: 05185 TEST: 04 TIME: 11:45:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01 ES 65143 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61052B
PATHOLOGIST: RICHARD LONG CAS: 542-56-3
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IITRI ISOBUTYL NITRITE (IBN) DATE: 05/20/95
EXPERIMENT: 05185 TEST: 04 TIME: 11:45:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01 ES 65143 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61052B
PATHOLOGIST: RICHARD LONG CAS: 542-56-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ISOBUTYL NITRITE (IBN)
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma or Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Uterus Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 2/59 (3%) 0/58 (0%) 1/58 (2%) | 0/55 (0%) 0/58 (0%) 2/54 (4%) 2/57 (4%) |
|ADJUSTED (b) | 0.0% 5.9% 0.0% 2.4% | 0.0% 0.0% 6.1% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/8 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 2/34 (6%) 0/35 (0%) 0/29 (0%) | 0/29 (0%) 0/40 (0%) 2/33 (6%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | --- 725 (T) --- 556 | --- --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.500 P=0.220 (e) P=0.495 | P=0.092 (e) P=0.267 P=0.280 |
|INCIDENTAL TUMOR | P=0.575 P=0.220 (e) P=0.617 | P=0.092 (e) P=0.267 P=0.280 |
|LOGISTIC REGRESSION | P=0.525 P=0.220 (e) P=0.508 | P=0.092 (e) P=0.267 P=0.280 |
|COCHRAN-ARMITAGE | P=0.537 | P=0.088 |
|FISHER EXACT | P=0.248 (e) P=0.496 | (e) P=0.243 P=0.257 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 2/59 (3%) 0/58 (0%) 1/58 (2%) | 0/55 (0%) 1/58 (2%) 2/54 (4%) 2/57 (4%) |
|ADJUSTED (b) | 0.0% 5.9% 0.0% 2.4% | 0.0% 2.0% 6.1% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/8 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 2/34 (6%) 0/35 (0%) 0/29 (0%) | 0/29 (0%) 0/40 (0%) 2/33 (6%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | --- 725 (T) --- 556 | --- 512 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.500 P=0.220 (e) P=0.495 | P=0.167 P=0.504 P=0.267 P=0.280 |
|INCIDENTAL TUMOR | P=0.575 P=0.220 (e) P=0.617 | P=0.207 (e) P=0.267 P=0.280 |
|LOGISTIC REGRESSION | P=0.525 P=0.220 (e) P=0.508 | P=0.158 P=0.467 P=0.267 P=0.280 |
|COCHRAN-ARMITAGE | P=0.537 | P=0.164 |
|FISHER EXACT | P=0.248 (e) P=0.496 | P=0.513 P=0.243 P=0.257 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 1/60 (2%) 3/60 (5%) 5/60 (8%) | 0/60 (0%) 1/60 (2%) 1/59 (2%) 2/60 (3%) |
|ADJUSTED (b) | 10.5% 2.9% 8.6% 16.7% | 0.0% 2.2% 2.8% 5.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/37 (8%) 1/35 (3%) 3/35 (9%) 5/30 (17%) | 0/32 (0%) 0/42 (0%) 1/36 (3%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | 711 725 (T) 725 (T) 725 (T) | --- 697 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.176 P=0.198N P=0.532N P=0.373 | P=0.162 P=0.556 P=0.523 P=0.271 |
|INCIDENTAL TUMOR | P=0.187 P=0.092N P=0.431N P=0.476 | P=0.145 P=0.362 P=0.523 P=0.271 |
|LOGISTIC REGRESSION | P=0.189 P=0.162N P=0.520N P=0.416 | P=0.152 P=0.513 P=0.523 P=0.271 |
|COCHRAN-ARMITAGE | P=0.264 | P=0.154 |
|FISHER EXACT | P=0.182N P=0.500N P=0.500 | P=0.500 P=0.496 P=0.248 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 1/60 (2%) 3/60 (5%) 6/60 (10%) | 0/60 (0%) 1/60 (2%) 1/59 (2%) 2/60 (3%) |
|ADJUSTED (b) | 10.5% 2.9% 8.6% 20.0% | 0.0% 2.2% 2.8% 5.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/37 (8%) 1/35 (3%) 3/35 (9%) 6/30 (20%) | 0/32 (0%) 0/42 (0%) 1/36 (3%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | 711 725 (T) 725 (T) 725 (T) | --- 697 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.088 P=0.198N P=0.532N P=0.247 | P=0.162 P=0.556 P=0.523 P=0.271 |
|INCIDENTAL TUMOR | P=0.093 P=0.092N P=0.431N P=0.330 | P=0.145 P=0.362 P=0.523 P=0.271 |
|LOGISTIC REGRESSION | P=0.095 P=0.162N P=0.520N P=0.284 | P=0.152 P=0.513 P=0.523 P=0.271 |
|COCHRAN-ARMITAGE | P=0.152 | P=0.154 |
|FISHER EXACT | P=0.182N P=0.500N P=0.372 | P=0.500 P=0.496 P=0.248 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/5 (40%) 1/3 (33%) 2/9 (22%) 0/1 (0%) | 0/2 (0%) 1/2 (50%) 0/3 (0%) 0/3 (0%) |
|ADJUSTED (b) | 40.0% 50.0% 16.6% 0.0% | 0.0% 50.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/0 0/1 (0%) 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|TERMINAL (d) | 2/5 (40%) 1/2 (50%) 1/7 (14%) 0/1 (0%) | 0/2 (0%) 1/2 (50%) 0/1 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 725 (T) 725 (T) 681 --- | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.343N P=0.712 P=0.610N P=0.638N | P=0.569N P=0.500 (e) (e) |
|INCIDENTAL TUMOR | P=0.253N P=0.712 P=0.373N P=0.638N | P=0.569N P=0.500 (e) (e) |
|LOGISTIC REGRESSION | P=0.333N P=0.712 P=0.488N P=0.638N | P=0.569N P=0.500 (e) (e) |
|COCHRAN-ARMITAGE | P=0.320N | P=0.497N |
|FISHER EXACT | P=0.714N P=0.455N P=0.667N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 1/60 (2%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.1% 5.6% 2.9% 7.6% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/37 (3%) 1/35 (3%) 1/35 (3%) 0/30 (0%) | 0/32 (0%) 0/42 (0%) 0/36 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 604 724 725 (T) 553 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.345 P=0.692N P=0.510N P=0.460 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.533 P=0.607N P=0.459N P=0.616N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.384 P=0.672N P=0.496N P=0.655 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.404 | (e) |
|FISHER EXACT | P=0.691N P=0.500N P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/60 (27%) 16/60 (27%) 18/60 (30%) 16/60 (27%) | 7/60 (12%) 10/60 (17%) 7/59 (12%) 6/60 (10%) |
|ADJUSTED (b) | 36.7% 38.8% 38.7% 40.0% | 19.3% 23.8% 19.4% 15.8% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 4/10 (40%) 2/7 (29%) | 1/9 (11%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 11/37 (30%) 11/35 (31%) 9/35 (26%) 8/30 (27%) | 5/32 (16%) 10/42 (24%) 7/36 (19%) 5/37 (14%) |
|FIRST INCIDENCE (DAYS) | 455 457 (I) 457 (I) 457 (I) | 458 (I) 729 (T) 729 (T) 724 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.268 P=0.550 P=0.387 P=0.345 | P=0.269N P=0.512 P=0.534N P=0.396N |
|INCIDENTAL TUMOR | P=0.449 P=0.365N P=0.560 P=0.580 | P=0.293N P=0.467 P=0.572N P=0.463N |
|LOGISTIC REGRESSION | P=0.465 P=0.519N P=0.429 P=0.540 | P=0.317N P=0.376 P=0.612 P=0.490N |
|COCHRAN-ARMITAGE | P=0.519 | P=0.322N |
|FISHER EXACT | P=0.582N P=0.420 P=0.582N | P=0.301 P=0.598 P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/60 (22%) 7/60 (12%) 11/60 (18%) 9/60 (15%) | 4/60 (7%) 5/60 (8%) 2/59 (3%) 5/60 (8%) |
|ADJUSTED (b) | 27.2% 15.8% 24.7% 23.6% | 9.8% 10.8% 5.6% 13.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 1/9 (11%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/37 (14%) 2/35 (6%) 3/35 (9%) 3/30 (10%) | 1/32 (3%) 3/42 (7%) 2/36 (6%) 4/37 (11%) |
|FIRST INCIDENCE (DAYS) | 455 457 (I) 484 552 | 572 458 (I) 729 (T) 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.460N P=0.116N P=0.418N P=0.358N | P=0.531 P=0.606 P=0.321N P=0.564 |
|INCIDENTAL TUMOR | P=0.190N P=0.104N P=0.351N P=0.159N | P=0.418 P=0.304 P=0.426N P=0.347 |
|LOGISTIC REGRESSION | P=0.165N P=0.136N P=0.265N P=0.157N | P=0.487 P=0.505 P=0.343N P=0.500 |
|COCHRAN-ARMITAGE | P=0.322N | P=0.500 |
|FISHER EXACT | P=0.110N P=0.410N P=0.240N | P=0.500 P=0.348N P=0.500 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/60 (45%) 21/60 (35%) 24/60 (40%) 18/60 (30%) | 11/60 (18%) 14/60 (23%) 7/59 (12%) 10/60 (17%) |
|ADJUSTED (b) | 54.1% 47.5% 48.6% 43.3% | 27.6% 31.4% 19.4% 25.6% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 2/10 (20%) 4/10 (40%) 2/7 (29%) | 1/9 (11%) 1/9 (11%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 15/37 (41%) 13/35 (37%) 11/35 (31%) 8/30 (27%) | 6/32 (19%) 12/42 (29%) 7/36 (19%) 8/37 (22%) |
|FIRST INCIDENCE (DAYS) | 455 457 (I) 457 (I) 457 (I) | 458 (I) 458 (I) 729 (T) 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292N P=0.215N P=0.406N P=0.241N | P=0.249N P=0.568 P=0.173N P=0.380N |
|INCIDENTAL TUMOR | P=0.087N P=0.119N P=0.282N P=0.057N | P=0.332N P=0.335 P=0.243N P=0.584N |
|LOGISTIC REGRESSION | P=0.074N P=0.150N P=0.266N P=0.066N | P=0.314N P=0.379 P=0.226N P=0.497N |
|COCHRAN-ARMITAGE | P=0.082N | P=0.303N |
|FISHER EXACT | P=0.176N P=0.356N P=0.066N | P=0.327 P=0.234N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/60 (45%) 21/60 (35%) 24/60 (40%) 18/60 (30%) | 11/60 (18%) 14/60 (23%) 7/59 (12%) 10/60 (17%) |
|ADJUSTED (b) | 54.1% 47.5% 48.6% 43.3% | 27.6% 31.4% 19.4% 25.6% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 2/10 (20%) 4/10 (40%) 2/7 (29%) | 1/9 (11%) 1/9 (11%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 15/37 (41%) 13/35 (37%) 11/35 (31%) 8/30 (27%) | 6/32 (19%) 12/42 (29%) 7/36 (19%) 8/37 (22%) |
|FIRST INCIDENCE (DAYS) | 455 457 (I) 457 (I) 457 (I) | 458 (I) 458 (I) 729 (T) 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292N P=0.215N P=0.406N P=0.241N | P=0.249N P=0.568 P=0.173N P=0.380N |
|INCIDENTAL TUMOR | P=0.087N P=0.119N P=0.282N P=0.057N | P=0.332N P=0.335 P=0.243N P=0.584N |
|LOGISTIC REGRESSION | P=0.074N P=0.150N P=0.266N P=0.066N | P=0.314N P=0.379 P=0.226N P=0.497N |
|COCHRAN-ARMITAGE | P=0.082N | P=0.303N |
|FISHER EXACT | P=0.176N P=0.356N P=0.066N | P=0.327 P=0.234N P=0.500N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 14/60 (23%) 13/59 (22%) 17/60 (28%) | 4/60 (7%) 16/60 (27%) 9/59 (15%) 19/60 (32%) |
|ADJUSTED (b) | 19.7% 36.6% 37.1% 49.2% | 11.7% 35.6% 21.4% 45.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/10 (20%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 2/9 (22%) 2/9 (22%) 2/10 (20%) |
|TERMINAL (d) | 6/37 (16%) 12/35 (34%) 13/35 (37%) 13/30 (43%) | 3/32 (9%) 14/42 (33%) 6/36 (17%) 15/37 (41%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 457 (I) 725 (T) 558 | 689 458 (I) 458 (I) 458 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.096 P=0.131 P=0.010 ** | P=0.005 ** P=0.015 * P=0.153 P=0.002 ** |
|INCIDENTAL TUMOR | P=0.014 * P=0.083 P=0.142 P=0.025 * | P=0.003 ** P=0.012 * P=0.120 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.019 * P=0.144 P=0.159 P=0.021 * | P=0.002 ** P=0.005 ** P=0.115 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.045 * | P=0.003 ** |
|FISHER EXACT | P=0.119 P=0.158 P=0.035 * | P=0.003 ** P=0.113 P<0.001 ** |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 6/60 (10%) 5/59 (8%) 4/60 (7%) | 2/60 (3%) 2/60 (3%) 2/59 (3%) 2/60 (3%) |
|ADJUSTED (b) | 2.7% 15.6% 14.3% 11.2% | 5.7% 4.8% 5.6% 5.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/37 (3%) 4/35 (11%) 5/35 (14%) 2/30 (7%) | 1/32 (3%) 2/42 (5%) 2/36 (6%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | 725 (T) 667 725 (T) 558 | 690 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.210 P=0.059 P=0.090 P=0.142 | P=0.575N P=0.602N P=0.662N P=0.647N |
|INCIDENTAL TUMOR | P=0.290 P=0.139 P=0.090 P=0.208 | P=0.596 P=0.684N P=0.668 P=0.693 |
|LOGISTIC REGRESSION | P=0.249 P=0.071 P=0.090 P=0.170 | P=0.588N P=0.646N P=0.688N P=0.676N |
|COCHRAN-ARMITAGE | P=0.301 | P=0.595 |
|FISHER EXACT | P=0.057 P=0.100 P=0.182 | P=0.691N P=0.684 P=0.691N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 18/60 (30%) 16/59 (27%) 19/60 (32%) | 6/60 (10%) 17/60 (28%) 11/59 (19%) 21/60 (35%) |
|ADJUSTED (b) | 22.3% 44.8% 45.7% 53.4% | 17.0% 37.9% 26.6% 50.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/10 (20%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 2/9 (22%) 2/9 (22%) 2/10 (20%) |
|TERMINAL (d) | 7/37 (19%) 14/35 (40%) 16/35 (46%) 14/30 (47%) | 4/32 (13%) 15/42 (36%) 8/36 (22%) 17/37 (46%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 457 (I) 725 (T) 558 | 689 458 (I) 458 (I) 458 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.032 * P=0.058 P=0.006 ** | P=0.005 ** P=0.043 * P=0.193 P=0.003 ** |
|INCIDENTAL TUMOR | P=0.017 * P=0.051 P=0.064 P=0.017 * | P=0.003 ** P=0.027 * P=0.137 P=0.001 ** |
|LOGISTIC REGRESSION | P=0.019 * P=0.053 P=0.077 P=0.014 * | P=0.003 ** P=0.015 * P=0.140 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.050 | P=0.004 ** |
|FISHER EXACT | P=0.040 * P=0.081 P=0.025 * | P=0.010 ** P=0.139 P<0.001 ** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 2/59 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 5.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 0/35 (0%) 0/35 (0%) 0/30 (0%) | 0/32 (0%) 0/42 (0%) 2/36 (6%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.607 (e) P=0.264 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.607 (e) P=0.264 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.607 (e) P=0.264 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.593 |
|FISHER EXACT | (e) (e) (e) | (e) P=0.244 (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 2/59 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 5.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 0/35 (0%) 0/35 (0%) 0/30 (0%) | 0/32 (0%) 0/42 (0%) 2/36 (6%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.607 (e) P=0.264 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.607 (e) P=0.264 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.607 (e) P=0.264 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.593 |
|FISHER EXACT | (e) (e) (e) | (e) P=0.244 (e) |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/58 (2%) 0/59 (0%) 2/55 (4%) 1/59 (2%) |
|ADJUSTED (b) | | 3.3% 0.0% 5.6% 2.7% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/30 (3%) 0/41 (0%) 1/32 (3%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- 663 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.521 P=0.438N P=0.515 P=0.715N |
|INCIDENTAL TUMOR | | P=0.491 P=0.438N P=0.437 P=0.715N |
|LOGISTIC REGRESSION | | P=0.505 P=0.438N P=0.483 P=0.715N |
|COCHRAN-ARMITAGE | | P=0.500 |
|FISHER EXACT | | P=0.496N P=0.480 P=0.748N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/56 (0%) 0/56 (0%) 1/54 (2%) 1/54 (2%) | 12/56 (21%) 19/56 (34%) 18/59 (31%) 13/57 (23%) |
|ADJUSTED (b) | 0.0% 0.0% 2.9% 3.8% | 34.2% 47.5% 47.1% 34.6% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/10 (0%) 0/8 (0%) 0/7 (0%) | 0/8 (0%) 0/8 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/36 (0%) 0/32 (0%) 1/34 (3%) 1/26 (4%) | 9/31 (29%) 19/40 (48%) 16/36 (44%) 11/35 (31%) |
|FIRST INCIDENCE (DAYS) | --- --- 725 (T) 725 (T) | 635 729 (T) 585 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.182 (e) P=0.489 P=0.435 | P=0.420N P=0.305 P=0.248 P=0.563N |
|INCIDENTAL TUMOR | P=0.182 (e) P=0.489 P=0.435 | P=0.523N P=0.178 P=0.183 P=0.413 |
|LOGISTIC REGRESSION | P=0.182 (e) P=0.489 P=0.435 | P=0.491N P=0.169 P=0.163 P=0.509 |
|COCHRAN-ARMITAGE | P=0.228 | P=0.445N |
|FISHER EXACT | (e) P=0.491 P=0.491 | P=0.102 P=0.185 P=0.520 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/56 (2%) 1/56 (2%) 0/54 (0%) 0/54 (0%) | 2/56 (4%) 2/56 (4%) 0/59 (0%) 0/57 (0%) |
|ADJUSTED (b) | 1.8% 3.1% 0.0% 0.0% | 6.5% 4.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/9 (11%) 0/10 (0%) 0/8 (0%) 0/7 (0%) | 0/8 (0%) 0/8 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/36 (0%) 1/32 (3%) 0/34 (0%) 0/26 (0%) | 2/31 (6%) 1/40 (3%) 0/36 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 725 (T) --- --- | 729 (T) 728 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277N P=0.759 P=0.523N P=0.550N | P=0.077N P=0.595N P=0.206N P=0.212N |
|INCIDENTAL TUMOR | P=0.277N P=0.759 P=0.523N P=0.550N | P=0.094N P=0.686 P=0.206N P=0.212N |
|LOGISTIC REGRESSION | P=0.229N P=0.745 P=0.591N P=0.472N | P=0.073N P=0.598N P=0.206N P=0.212N |
|COCHRAN-ARMITAGE | P=0.241N | P=0.082N |
|FISHER EXACT | P=0.752N P=0.509N P=0.509N | P=0.691N P=0.235N P=0.243N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 1/60 (2%) 0/60 (0%) 2/59 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.3% | 3.1% 0.0% 4.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 0/35 (0%) 0/35 (0%) 1/30 (3%) | 1/32 (3%) 0/42 (0%) 1/36 (3%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 725 (T) | 729 (T) --- 434 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.173 (e) (e) P=0.458 | P=0.454N P=0.446N P=0.525 P=0.471N |
|INCIDENTAL TUMOR | P=0.173 (e) (e) P=0.458 | P=0.361N P=0.446N P=0.736N P=0.471N |
|LOGISTIC REGRESSION | P=0.173 (e) (e) P=0.458 | P=0.459N P=0.446N P=0.492 P=0.471N |
|COCHRAN-ARMITAGE | P=0.198 | P=0.463N |
|FISHER EXACT | (e) (e) P=0.500 | P=0.500N P=0.494 P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 1/60 (2%) 0/60 (0%) 2/59 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.3% | 3.1% 0.0% 4.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 0/35 (0%) 0/35 (0%) 1/30 (3%) | 1/32 (3%) 0/42 (0%) 1/36 (3%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 725 (T) | 729 (T) --- 434 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.173 (e) (e) P=0.458 | P=0.454N P=0.446N P=0.525 P=0.471N |
|INCIDENTAL TUMOR | P=0.173 (e) (e) P=0.458 | P=0.361N P=0.446N P=0.736N P=0.471N |
|LOGISTIC REGRESSION | P=0.173 (e) (e) P=0.458 | P=0.459N P=0.446N P=0.492 P=0.471N |
|COCHRAN-ARMITAGE | P=0.198 | P=0.463N |
|FISHER EXACT | (e) (e) P=0.500 | P=0.500N P=0.494 P=0.500N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 5/60 (8%) | 4/60 (7%) 3/60 (5%) 2/59 (3%) 2/60 (3%) |
|ADJUSTED (b) | 2.7% 0.0% 0.0% 16.7% | 11.6% 7.1% 5.6% 5.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/37 (3%) 0/35 (0%) 0/35 (0%) 5/30 (17%) | 3/32 (9%) 3/42 (7%) 2/36 (6%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | 725 (T) --- --- 725 (T) | 649 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004 ** P=0.511N P=0.511N P=0.061 | P=0.224N P=0.366N P=0.294N P=0.282N |
|INCIDENTAL TUMOR | P=0.004 ** P=0.511N P=0.511N P=0.061 | P=0.240N P=0.425N P=0.342N P=0.317N |
|LOGISTIC REGRESSION | P=0.004 ** P=0.511N P=0.511N P=0.061 | P=0.241N P=0.430N P=0.331N P=0.317N |
|COCHRAN-ARMITAGE | P=0.009 ** | P=0.250N |
|FISHER EXACT | P=0.500N P=0.500N P=0.103 | P=0.500N P=0.348N P=0.340N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 5/60 (8%) | 4/60 (7%) 3/60 (5%) 2/59 (3%) 2/60 (3%) |
|ADJUSTED (b) | 2.7% 2.9% 0.0% 16.7% | 11.6% 7.1% 5.6% 5.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/37 (3%) 1/35 (3%) 0/35 (0%) 5/30 (17%) | 3/32 (9%) 3/42 (7%) 2/36 (6%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | 725 (T) 725 (T) --- 725 (T) | 649 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.011 * P=0.749 P=0.511N P=0.061 | P=0.224N P=0.366N P=0.294N P=0.282N |
|INCIDENTAL TUMOR | P=0.011 * P=0.749 P=0.511N P=0.061 | P=0.240N P=0.425N P=0.342N P=0.317N |
|LOGISTIC REGRESSION | P=0.011 * P=0.749 P=0.511N P=0.061 | P=0.241N P=0.430N P=0.331N P=0.317N |
|COCHRAN-ARMITAGE | P=0.022 * | P=0.250N |
|FISHER EXACT | P=0.752N P=0.500N P=0.103 | P=0.500N P=0.348N P=0.340N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/60 (5%) 2/60 (3%) 0/59 (0%) 1/60 (2%) |
|ADJUSTED (b) | | 9.4% 4.8% 0.0% 2.7% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | | 3/32 (9%) 2/42 (5%) 0/36 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.146N P=0.377N P=0.101N P=0.254N |
|INCIDENTAL TUMOR | | P=0.146N P=0.377N P=0.101N P=0.254N |
|LOGISTIC REGRESSION | | P=0.146N P=0.377N P=0.101N P=0.254N |
|COCHRAN-ARMITAGE | | P=0.165N |
|FISHER EXACT | | P=0.500N P=0.125N P=0.309N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 4/60 (7%) 2/60 (3%) 0/59 (0%) 1/60 (2%) |
|ADJUSTED (b) | | 12.5% 4.8% 0.0% 2.7% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | | 4/32 (13%) 2/42 (5%) 0/36 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.073N P=0.220N P=0.049N* P=0.137N |
|INCIDENTAL TUMOR | | P=0.073N P=0.220N P=0.049N* P=0.137N |
|LOGISTIC REGRESSION | | P=0.073N P=0.220N P=0.047N* P=0.137N |
|COCHRAN-ARMITAGE | | P=0.087N |
|FISHER EXACT | | P=0.340N P=0.061N P=0.182N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 0/59 (0%) 1/60 (2%) |
|ADJUSTED (b) | 2.7% 0.0% 0.0% 0.0% | 6.0% 2.4% 0.0% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/37 (3%) 0/35 (0%) 0/35 (0%) 0/30 (0%) | 1/32 (3%) 1/42 (2%) 0/36 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 725 (T) --- --- --- | 709 729 (T) --- 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.329N P=0.511N P=0.511N P=0.542N | P=0.343N P=0.410N P=0.218N P=0.439N |
|INCIDENTAL TUMOR | P=0.329N P=0.511N P=0.511N P=0.542N | P=0.418N P=0.515N P=0.299N P=0.593N |
|LOGISTIC REGRESSION | P=0.329N P=0.511N P=0.511N P=0.542N | P=0.363N P=0.443N P=0.232N P=0.482N |
|COCHRAN-ARMITAGE | P=0.307N | P=0.368N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.500N P=0.252N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 2/60 (3%) 3/60 (5%) | 1/60 (2%) 3/60 (5%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.1% 8.3% 5.7% 7.6% | 2.6% 7.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/37 (3%) 2/35 (6%) 2/35 (6%) 0/30 (0%) | 0/32 (0%) 3/42 (7%) 0/36 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 604 724 725 (T) 553 | 690 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.384 P=0.495 P=0.681 P=0.460 | P=0.141N P=0.398 P=0.500N P=0.485N |
|INCIDENTAL TUMOR | P=0.555 P=0.594 P=0.668N P=0.616N | P=0.163N P=0.316 P=0.638N P=0.594N |
|LOGISTIC REGRESSION | P=0.427 P=0.532 P=0.692N P=0.655 | P=0.148N P=0.354 P=0.502N P=0.500N |
|COCHRAN-ARMITAGE | P=0.457 | P=0.152N |
|FISHER EXACT | P=0.500 P=0.691N P=0.500 | P=0.309 P=0.504N P=0.500N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 2/60 (3%) 3/60 (5%) | 3/60 (5%) 4/60 (7%) 0/59 (0%) 1/60 (2%) |
|ADJUSTED (b) | 7.8% 8.3% 5.7% 7.6% | 8.4% 9.5% 0.0% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/37 (5%) 2/35 (6%) 2/35 (6%) 0/30 (0%) | 1/32 (3%) 4/42 (10%) 0/36 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 604 724 725 (T) 553 | 690 729 (T) --- 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.526 P=0.652 P=0.518N P=0.609 | P=0.097N P=0.633 P=0.112N P=0.257N |
|INCIDENTAL TUMOR | P=0.478N P=0.595N P=0.478N P=0.443N | P=0.136N P=0.501 P=0.195N P=0.418N |
|LOGISTIC REGRESSION | P=0.571 P=0.629N P=0.498N P=0.652 | P=0.107N P=0.580 P=0.120N P=0.545N |
|COCHRAN-ARMITAGE | P=0.562N | P=0.112N |
|FISHER EXACT | P=0.660N P=0.500N P=0.660N | P=0.500 P=0.125N P=0.309N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 2/60 (3%) 0/59 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.5% 4.8% 0.0% 4.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 0/35 (0%) 0/35 (0%) 0/30 (0%) | 0/32 (0%) 2/42 (5%) 0/36 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 576 729 (T) --- 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.553N P=0.633N P=0.252N P=0.686N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.589N P=0.499 P=0.327N P=0.727N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.556N P=0.688N P=0.245N P=0.537 |
|COCHRAN-ARMITAGE | (e) | P=0.555N |
|FISHER EXACT | (e) (e) (e) | P=0.691N P=0.252N P=0.691N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 2/60 (3%) 2/60 (3%) | 8/60 (13%) 8/60 (13%) 11/59 (19%) 11/60 (18%) |
|ADJUSTED (b) | 2.6% 7.7% 5.7% 5.9% | 19.3% 17.9% 27.6% 25.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 2/35 (6%) 2/35 (6%) 1/30 (3%) | 3/32 (9%) 6/42 (14%) 8/36 (22%) 7/37 (19%) |
|FIRST INCIDENCE (DAYS) | 618 581 725 (T) 625 | 576 520 558 114 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.432 P=0.323 P=0.490 P=0.467 | P=0.243 P=0.453N P=0.364 P=0.382 |
|INCIDENTAL TUMOR | P=0.581 P=0.205 P=0.541 P=0.612 | P=0.153 P=0.500 P=0.200 P=0.206 |
|LOGISTIC REGRESSION | P=0.473 P=0.314 P=0.504 P=0.703 | P=0.204 P=0.337 P=0.170 P=0.306 |
|COCHRAN-ARMITAGE | P=0.501 | P=0.217 |
|FISHER EXACT | P=0.309 P=0.500 P=0.500 | P=0.605N P=0.295 P=0.309 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 2/60 (3%) 2/60 (3%) | 7/60 (12%) 6/60 (10%) 11/59 (19%) 9/60 (15%) |
|ADJUSTED (b) | 2.6% 7.7% 5.7% 5.9% | 17.6% 13.3% 27.6% 21.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) | 0/9 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/37 (0%) 2/35 (6%) 2/35 (6%) 1/30 (3%) | 3/32 (9%) 4/42 (10%) 8/36 (22%) 6/37 (16%) |
|FIRST INCIDENCE (DAYS) | 618 581 725 (T) 625 | 585 520 558 114 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.432 P=0.323 P=0.490 P=0.467 | P=0.277 P=0.367N P=0.276 P=0.471 |
|INCIDENTAL TUMOR | P=0.581 P=0.205 P=0.541 P=0.612 | P=0.174 P=0.582N P=0.144 P=0.233 |
|LOGISTIC REGRESSION | P=0.473 P=0.314 P=0.504 P=0.703 | P=0.236 P=0.492 P=0.123 P=0.390 |
|COCHRAN-ARMITAGE | P=0.501 | P=0.251 |
|FISHER EXACT | P=0.309 P=0.500 P=0.500 | P=0.500N P=0.210 P=0.395 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 28/60 (47%) 31/60 (52%) 33/60 (55%) 36/60 (60%) | 28/60 (47%) 38/60 (63%) 31/59 (53%) 35/60 (58%) |
|ADJUSTED (b) | 61.1% 71.3% 72.5% 81.1% | 69.3% 82.4% 73.3% 77.5% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 3/10 (30%) 4/10 (40%) 3/7 (43%) | 1/9 (11%) 2/9 (22%) 2/9 (22%) 2/10 (20%) |
|TERMINAL (d) | 20/37 (54%) 23/35 (66%) 23/35 (66%) 22/30 (73%) | 20/32 (63%) 34/42 (81%) 25/36 (69%) 27/37 (73%) |
|FIRST INCIDENCE (DAYS) | 455 457 (I) 457 (I) 296 | 458 (I) 458 (I) 458 (I) 458 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006 ** P=0.302 P=0.184 P=0.013 * | P=0.357 P=0.429 P=0.549 P=0.362 |
|INCIDENTAL TUMOR | P=0.026 * P=0.543 P=0.346 P=0.069 | P=0.162 P=0.124 P=0.305 P=0.086 |
|LOGISTIC REGRESSION | P=0.033 * P=0.457 P=0.254 P=0.058 | P=0.152 P=0.082 P=0.304 P=0.100 |
|COCHRAN-ARMITAGE | P=0.081 | P=0.240 |
|FISHER EXACT | P=0.358 P=0.233 P=0.100 | P=0.049 * P=0.324 P=0.136 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 17/60 (28%) 19/60 (32%) 22/60 (37%) 17/60 (28%) | 17/60 (28%) 18/60 (30%) 19/59 (32%) 19/60 (32%) |
|ADJUSTED (b) | 35.2% 42.2% 48.0% 40.5% | 38.1% 36.9% 45.1% 44.4% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 1/10 (10%) 0/7 (0%) | 0/9 (0%) 1/9 (11%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/37 (19%) 10/35 (29%) 12/35 (34%) 6/30 (20%) | 6/32 (19%) 12/42 (29%) 14/36 (39%) 14/37 (38%) |
|FIRST INCIDENCE (DAYS) | 455 457 (I) 457 (I) 552 | 572 458 (I) 210 114 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.333 P=0.447 P=0.233 P=0.427 | P=0.433 P=0.408N P=0.507 P=0.554 |
|INCIDENTAL TUMOR | P=0.345N P=0.470 P=0.239 P=0.341N | P=0.291 P=0.295 P=0.278 P=0.225 |
|LOGISTIC REGRESSION | P=0.349N P=0.444 P=0.325 P=0.355N | P=0.349 P=0.184 P=0.403 P=0.409 |
|COCHRAN-ARMITAGE | P=0.528N | P=0.376 |
|FISHER EXACT | P=0.421 P=0.218 P=0.580N | P=0.500 P=0.397 P=0.421 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05185 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ISOBUTYL NITRITE (IBN)
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 37.5 PPM 75 PPM 150 PPM | CONTROL 37.5 PPM 75 PPM 150 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 38/60 (63%) 39/60 (65%) 43/60 (72%) 42/60 (70%) | 38/60 (63%) 48/60 (80%) 39/59 (66%) 42/60 (70%) |
|ADJUSTED (b) | 71.4% 80.8% 84.0% 85.6% | 80.4% 92.2% 84.3% 87.3% |
|INTERIM SACRIFICE 1 (c)| 5/10 (50%) 4/10 (40%) 5/10 (50%) 3/7 (43%) | 1/9 (11%) 3/9 (33%) 2/9 (22%) 2/10 (20%) |
|TERMINAL (d) | 22/37 (59%) 26/35 (74%) 27/35 (77%) 23/30 (77%) | 23/32 (72%) 38/42 (90%) 29/36 (81%) 31/37 (84%) |
|FIRST INCIDENCE (DAYS) | 455 457 (I) 457 (I) 296 | 458 (I) 458 (I) 210 114 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * P=0.463 P=0.219 P=0.073 | P=0.453N P=0.535 P=0.442N P=0.535N |
|INCIDENTAL TUMOR | P=0.145 P=0.565N P=0.311 P=0.324 | P=0.325 P=0.028 * P=0.385 P=0.100 |
|LOGISTIC REGRESSION | P=0.096 P=0.570N P=0.279 P=0.156 | P=0.346 P=0.014 * P=0.445 P=0.213 |
|COCHRAN-ARMITAGE | P=0.214 | P=0.468 |
|FISHER EXACT | P=0.500 P=0.218 P=0.281 | P=0.034 * P=0.451 P=0.281 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 457
Female interim sacrifices(days): 458
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).