TDMS Study 05185-04 Pathology Tables
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
Facility: I. I. T. Research Institute
Chemical CAS #: 542-56-3
Lock Date: 08/20/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 0| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 0| 2| 7| 3| 2| 3| 8| 2| 2| 2| 3| 3| 9| 9| 8| 3| 1| 2| 7| 3| 9| 8| 2| 2|
| 1| 9| 9| 2| 1| 9| 0| 9| 9| 9| 9| 1| 1| 0| 1| 5| 1| 3| 9| 1| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + A + + + + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cytologic Alterations | 3 |
Eosinophilic Focus | |
Fatty Change, Diffuse | 1 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 |
Mixed Cell Focus | X X |
Necrosis | |
Fat, Necrosis | 1 |
Hepatocyte, Necrosis | 2 |
Periportal, Fatty Change | |
__________________________________________________________________________|
Mesentery | + + +|
Artery, Inflammation, Chronic | |
Fat, Necrosis | 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 2 1 2 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | |
Inflammation, Chronic | 1 |
Thrombosis | 1 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 3 2 2 1 3 2 3 2 3 2 2 1 2 2 2 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 0| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 0| 2| 7| 3| 2| 3| 8| 2| 2| 2| 3| 3| 9| 9| 8| 3| 1| 2| 7| 3| 9| 8| 2| 2|
| 1| 9| 9| 2| 1| 9| 0| 9| 9| 9| 9| 1| 1| 0| 1| 5| 1| 3| 9| 1| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + M + M M + + M + + M + M M M M + M + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + M|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 3 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 4 |
Follicular Cell, Hyperplasia, Diffuse| |
Follicular Cell, Hyperplasia, Focal | 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | 2 4 3 |
Infiltration Cellular, Lymphocyte | |
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2|
Hemorrhage | |
Hyperplasia, Cystic | 2 3 2 1 1 1 3 3 2 1 2 3 3 2 2 1 3 2 3 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + M M + + M + + M M M + + + + M M + M M|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 0| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 0| 2| 7| 3| 2| 3| 8| 2| 2| 2| 3| 3| 9| 9| 8| 3| 1| 2| 7| 3| 9| 8| 2| 2|
| 1| 9| 9| 2| 1| 9| 0| 9| 9| 9| 9| 1| 1| 0| 1| 5| 1| 3| 9| 1| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 1 3 1 1 2 1 2 1 1 1 1 1 1 1 1|
Hyperplasia, Lymphoid | 2 2 3 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + M + + + +|
Atrophy | 2 4 1 3 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + M + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 3 1 4 2 1 3 3 1 1 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization | 2 2 2 2 1 1 1 2 3 1 1 1 3 1 2 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Exudate, Serous | |
Inflammation, Chronic Active | 1 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
Respiratory Epithelium, Ulcer | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 0| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 0| 2| 7| 3| 2| 3| 8| 2| 2| 2| 3| 3| 9| 9| 8| 3| 1| 2| 7| 3| 9| 8| 2| 2|
| 1| 9| 9| 2| 1| 9| 0| 9| 9| 9| 9| 1| 1| 0| 1| 5| 1| 3| 9| 1| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cyst | |
Hydronephrosis | |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 3 1 1 1 2 1 |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 3 1 1 1 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 9| 3| 4| 2| 3| 9| 4| 3|
| 0| 1| 9| 8| 6| 9| 9| 0| 0| 5| 9| 0| 0| 0| 1| 9| 1| 5| 0| 9| 9| 0| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + A + + + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + A + + + + + + + M + + + + A A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + + + + + A + + + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Cytologic Alterations | 3 |
Eosinophilic Focus | X |
Fatty Change, Diffuse | |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 |
Inflammation, Chronic Active | |
Mixed Cell Focus | X |
Necrosis | 2 |
Fat, Necrosis | |
Hepatocyte, Necrosis | |
Periportal, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic | 3 |
Fat, Necrosis | 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 2|
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 1 1 2 2 1 1 1 2 3 3 1 2 2 1 1 2 2 2 1 1 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 2 |
Inflammation, Chronic | |
Thrombosis | |
Artery, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 2 1 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 1 4 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 9| 3| 4| 2| 3| 9| 4| 3|
| 0| 1| 9| 8| 6| 9| 9| 0| 0| 5| 9| 0| 0| 0| 1| 9| 1| 5| 0| 9| 9| 0| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Parathyroid Gland | M M M M M + + + M M + M + + M M M M M + M + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 1 4 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Diffuse| 4 |
Follicular Cell, Hyperplasia, Focal | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | 3 4 2 2 3 |
Infiltration Cellular, Lymphocyte | 2 |
Interstitium, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Hyperplasia, Cystic | 2 3 3 1 3 2 3 4 4 3 2 4 2 1 3 1 3 1 2 1|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M M M + + + M + M M M M M M M M M M M M M M|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 9| 3| 4| 2| 3| 9| 4| 3|
| 0| 1| 9| 8| 6| 9| 9| 0| 0| 5| 9| 0| 0| 0| 1| 9| 1| 5| 0| 9| 9| 0| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 1 1 1 3 4 1 1 1 1 1 1 1 1 1 4 1 1 1 1 1 3 1|
Hyperplasia, Lymphoid | 3 2 2 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Atrophy | 3 2 4 3 3 3 |
Hyperplasia, Lymphoid | 3 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Mineralization | 2 2 2 2 2 1 2 2 2 1 2 2 1 2 1 2 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Inflammation, Chronic Active | 2 1 |
Leukocytosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Exudate, Serous | 1 |
Inflammation, Chronic Active | 1 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 |
Respiratory Epithelium, Ulcer | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 9| 3| 4| 2| 3| 9| 4| 3|
| 0| 1| 9| 8| 6| 9| 9| 0| 0| 5| 9| 0| 0| 0| 1| 9| 1| 5| 0| 9| 9| 0| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Cyst | 2 |
Hydronephrosis | 2 |
Infiltration Cellular, Lymphocyte | 1 3 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Renal Tubule, Degeneration, Hyaline | 2 |
Renal Tubule, Dilatation | 3 3 |
Renal Tubule, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M A + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 1 2 1 2 2 2 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 |
Cytologic Alterations | | 2 3.0|
Eosinophilic Focus | | 1 |
Fatty Change, Diffuse | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic | | 11 1.1|
Inflammation, Chronic Active | | 2 1.0|
Mixed Cell Focus | | 3 |
Necrosis | | 1 2.0|
Fat, Necrosis | | 1 1.0|
Hepatocyte, Necrosis | | 1 2.0|
Periportal, Fatty Change | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Artery, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | | 5 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 4 2.3|
Acinus, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 2 1 1 1 | 49 1.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Infiltration Cellular | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Thrombosis | | 1 1.0|
Artery, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 2 1 | 56 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 2 |
Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 56 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | | 10 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | | 1 4.0|
Follicular Cell, Hyperplasia, Diffuse| | 1 4.0|
Follicular Cell, Hyperplasia, Focal | | 5 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Cyst | 3 1 | 10 2.7|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Interstitium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.5|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Cystic | 1 3 2 1 1 2 1 1 1 | 49 2.1|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Degeneration, Fatty | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + | 28 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 6 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Atrophy | 3 | 1 3.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 | 54 1.3|
Hyperplasia, Lymphoid | | 6 2.3|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 | 54 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + | 56 |
Atrophy | | 11 2.8|
Hyperplasia, Lymphoid | 3 | 5 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 6 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Dysplasia | 2 1 | 24 1.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + M + + + + + | 59 |
Compression | | 1 4.0|
Mineralization | 1 1 1 1 1 2 | 45 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 | 28 1.1|
Inflammation, Chronic Active | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukocytosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 1 2.0|
Exudate, Serous | | 1 1.0|
Inflammation, Chronic Active | | 6 1.2|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 4 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 | 19 1.0|
Respiratory Epithelium, Hyperplasia | | 6 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 4 1.3|
Respiratory Epithelium, Ulcer | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 4.0|
Cyst | | 1 2.0|
Hydronephrosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 | 35 1.2|
Renal Tubule, Degeneration, Hyaline | | 1 2.0|
Renal Tubule, Dilatation | | 2 3.0|
Renal Tubule, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 | 38 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 0| 2| 3| 3| 1| 4| 2| 3| 2| 3| 3| 3|
| 1| 9| 7| 0| 1| 1| 1| 9| 0| 1| 9| 8| 0| 7| 9| 0| 0| 4| 5| 9| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
37.5 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + M M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Proliferation Connective Tissue | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Proliferation Connective Tissue | |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Cytologic Alterations | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | |
Mitotic Alteration | 1 |
Mixed Cell Focus | X |
Necrosis | 1 |
Proliferation Connective Tissue | |
Hepatocyte, Necrosis | 1 |
Periportal, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Cyst | 4 |
Proliferation Connective Tissue | X |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Inflammation, Chronic Active | 4 |
Acinus, Atrophy | 3 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 2 1 1 1 1 2 1 1 1 1 2 1 1 2 1 2 2|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Proliferation Connective Tissue | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Proliferation Connective Tissue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 0| 2| 3| 3| 1| 4| 2| 3| 2| 3| 3| 3|
| 1| 9| 7| 0| 1| 1| 1| 9| 0| 1| 9| 8| 0| 7| 9| 0| 0| 4| 5| 9| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
37.5 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | 1 |
Subcapsular, Hyperplasia | 2 2 2 3 2 2 1 1 2 2 2 3 2 2 3 2 2 2 2 1 2 1 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + M M + M M M + M + + + + M + + M M M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 3 2 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Follicle, Cyst | 2 3 2 |
Follicular Cell, Hyperplasia, Focal | 2 2 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 3 4 4 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hyperplasia, Cystic | 2 3 1 4 2 3 1 1 3 1 2 1 2 2 1 1 4 1 |
Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + |
Hyperplasia, Lymphoid | 3 |
Pigmentation | |
Iliac, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 0| 2| 3| 3| 1| 4| 2| 3| 2| 3| 3| 3|
| 1| 9| 7| 0| 1| 1| 1| 9| 0| 1| 9| 8| 0| 7| 9| 0| 0| 4| 5| 9| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
37.5 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + M M + + M M M M + M + M +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 4 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + + + + + + + + + M +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + + + + + + + + M M + + + + + + M + +|
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 1 1 1 1 1 1 3 1 2 1 1 1 2 1 2 1 1|
Hyperplasia, Lymphoid | 2 1 2 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Proliferation Connective Tissue | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia, Lymphoid | 2 2 3 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 3 |
Ulcer | |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Dysplasia | 2 1 1 2 1 2 1 4|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
Proliferation Connective Tissue | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Mineralization | 2 1 2 1 3 1 2 2 1 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 0| 2| 3| 3| 1| 4| 2| 3| 2| 3| 3| 3|
| 1| 9| 7| 0| 1| 1| 1| 9| 0| 1| 9| 8| 0| 7| 9| 0| 0| 4| 5| 9| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
37.5 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Artery, Inflammation, Chronic | 3 |
Fat, Mediastinum, Necrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | |
Inflammation, Chronic Active | 1 1 1 1 2 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 |
Olfactory Epithelium, Metaplasia | 1 1 1 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 2 |
Respiratory Epithelium, Ulcer | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 3 1 1 1 2 1 1 1 |
Nephropathy | 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Pigmentation | 1 |
Renal Tubule, Regeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 2| 3| 2| 2| 3| 3| 2| 3| 8| 1| 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2|
| 9| 9| 0| 9| 9| 1| 9| 9| 1| 0| 9| 0| 6| 2| 9| 0| 0| 0| 1| 9| 9| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Proliferation Connective Tissue | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Proliferation Connective Tissue | X |
Serosa, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cytologic Alterations | 2 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 2 2 |
Mitotic Alteration | |
Mixed Cell Focus | |
Necrosis | 1 |
Proliferation Connective Tissue | X |
Hepatocyte, Necrosis | |
Periportal, Hypertrophy | |
__________________________________________________________________________|
Mesentery | + |
Cyst | |
Proliferation Connective Tissue | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic Active | |
Acinus, Atrophy | 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 1 1 1 1 1 1 1 1 2 2 1 2 3 1 1 1 1|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Proliferation Connective Tissue | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Proliferation Connective Tissue | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 2| 3| 2| 2| 3| 3| 2| 3| 8| 1| 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2|
| 9| 9| 0| 9| 9| 1| 9| 9| 1| 0| 9| 0| 6| 2| 9| 0| 0| 0| 1| 9| 9| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 2 2 2 1 2 3 2 1 1 3 3 2 1 1 2 2 1 1 3 1 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + M + M + + + + + + + M M + M M + + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Pars Distalis, Cyst | 1|
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia | 3 2 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Follicle, Cyst | 4 2 |
Follicular Cell, Hyperplasia, Focal | 2 3 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 3 4 2 4 4 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Cystic | 3 3 2 2 3 2 1 1 1 1 2 2 2 2 1 2 2 1 1 1 2 3 3 4|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + |
Hyperplasia, Lymphoid | |
Pigmentation | 3 |
Iliac, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 2| 3| 2| 2| 3| 3| 2| 3| 8| 1| 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2|
| 9| 9| 0| 9| 9| 1| 9| 9| 1| 0| 9| 0| 6| 2| 9| 0| 0| 0| 1| 9| 9| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M M + M + M + + M + + + M M|
Hemorrhage | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 1 1 1 1 3 1 2 3 1 1 1 1 1 1|
Hyperplasia, Lymphoid | 3 2 4 2 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Proliferation Connective Tissue | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M M + + + + + + + M + + +|
Atrophy | |
Hyperplasia, Lymphoid | 2 1 1 2 2 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Ulcer | 4 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Dysplasia | 2 1 1 1 2 1 2 1 1 2|
Hyperostosis | 2|
__________________________________________________________________________|
Skeletal Muscle | + + |
Proliferation Connective Tissue | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization | 2 1 1 1 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 2| 3| 2| 2| 3| 3| 2| 3| 8| 1| 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2|
| 9| 9| 0| 9| 9| 1| 9| 9| 1| 0| 9| 0| 6| 2| 9| 0| 0| 0| 1| 9| 9| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 1|
Inflammation, Chronic Active | 2 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Inflammation, Chronic | |
Fat, Mediastinum, Necrosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | 1 |
Inflammation, Chronic Active | 1 2 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Olfactory Epithelium, Metaplasia | 1 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
Respiratory Epithelium, Ulcer | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1 1 1 1|
Nephropathy | 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | 1 3 2 1 1 2 1 2 1 1 1 1 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 59 |
Ectopic Tissue | | 1 |
Proliferation Connective Tissue | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + M | 59 |
Hyperplasia, Lymphoid | | 1 3.0|
Proliferation Connective Tissue | | 1 |
Serosa, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 1 |
Cytologic Alterations | | 1 2.0|
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic | | 7 1.0|
Inflammation, Chronic Active | | 2 2.0|
Mitotic Alteration | | 1 1.0|
Mixed Cell Focus | | 1 |
Necrosis | | 2 1.0|
Proliferation Connective Tissue | | 1 |
Hepatocyte, Necrosis | | 1 1.0|
Periportal, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Cyst | | 1 4.0|
Proliferation Connective Tissue | | 1 |
Fat, Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Fibrosis | | 1 4.0|
Inflammation, Chronic Active | | 1 4.0|
Acinus, Atrophy | | 2 3.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 1 2 1 | 44 1.4|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Proliferation Connective Tissue | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Proliferation Connective Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Artery, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia, Focal | | 2 1.5|
Hypertrophy, Focal | | 1 1.0|
Subcapsular, Hyperplasia | 2 1 2 1 1 1 2 1 1 | 56 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 2 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + | 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 56 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
Pars Distalis, Hyperplasia | | 12 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Follicle, Cyst | | 5 2.6|
Follicular Cell, Hyperplasia, Focal | | 9 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cyst | 2 | 15 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
Hyperplasia, Cystic | 2 1 2 2 1 2 2 2 2 | 51 1.9|
Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Myeloid Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + M | 42 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + M M + | 51 |
Hyperplasia, Lymphoid | | 4 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 1 1 3 1 1 1 1 | 49 1.3|
Hyperplasia, Lymphoid | | 7 2.3|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 2 | 52 1.1|
Proliferation Connective Tissue | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Atrophy | 3 | 2 2.5|
Hyperplasia, Lymphoid | | 10 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 4 2.3|
Ulcer | | 1 4.0|
Epithelium, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Dysplasia | | 18 1.6|
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Proliferation Connective Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 2.0|
Mineralization | 1 1 2 1 1 | 26 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 14 1.1|
Inflammation, Chronic Active | | 3 1.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 4.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Artery, Inflammation, Chronic | | 1 3.0|
Fat, Mediastinum, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate, Serous | | 1 1.0|
Inflammation, Chronic Active | 1 | 10 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 3 1.0|
Olfactory Epithelium, Metaplasia | | 6 1.0|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 26 1.1|
Respiratory Epithelium, Hyperplasia | | 3 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 5 1.4|
Respiratory Epithelium, Ulcer | | 4 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 19 1.2|
Nephropathy | | 2 1.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Pigmentation | | 1 1.0|
Renal Tubule, Regeneration | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 | 40 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Cytologic Alterations | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | X |
Necrosis | 1 3 |
Hepatocyte, Necrosis | |
Periportal, Fatty Change | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 3 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Inflammation, Chronic | 1 1 1 2 2 2 2 2 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Artery, Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 3 |
Hypertrophy, Focal | 1 1 |
Subcapsular, Hyperplasia | 2 2 1 2 2 1 2 2 2 1 1 2 2 2 2 2 1 2 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
Hyperplasia, Focal | 2 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + M M M + M M M + + + + + + + M + M + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 3 2 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | |
Inflammation, Chronic | 1 |
Follicle, Cyst | 4 |
Follicular Cell, Hyperplasia, Diffuse| |
Follicular Cell, Hyperplasia, Focal | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + M + + + + +|
Cyst | 2 3 3 1 4 2 |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hyperplasia, Cystic | 1 1 1 2 1 1 1 1 3 3 2 2 3 1 2 2 2 3 2 1 3 1|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hemorrhage | |
Iliac, Inflammation, Chronic Active | 2 |
Lumbar, Angiectasis | 2 |
Lumbar, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + M + + M M + + + + + M + + + M M + M +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 1 4 3 1 2 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia, Lymphoid | 1 2 |
Pigmentation, Hemosiderin | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Epithelium, Hyperplasia | 1 |
Sebaceous Gland, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 1 1 2 1 1 1 1 1 2 2 1|
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | |
Mineralization | 2 2 1 2 2 1 2 2 2 2 2 3 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 3 |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 3 2 4 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | 1 |
Inflammation, Chronic Active | 2 1 1 1 1 |
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 2 2 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 |
Respiratory Epithelium, Ulcer | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 |
Nephropathy | |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 0| 5|
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + A + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Cytologic Alterations | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 1|
Mixed Cell Focus | |
Necrosis | |
Hepatocyte, Necrosis | 1 |
Periportal, Fatty Change | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | 3 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 |
Artery, Hypertrophy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 0| 5|
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 3 2 2 2 4 1 2 2 1 1 2 2 2 1 2 1 3 3 2 2 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M M + + M + M M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 3 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | X |
Inflammation, Chronic | 3 1 |
Follicle, Cyst | 1 3 1 |
Follicular Cell, Hyperplasia, Diffuse| 4 |
Follicular Cell, Hyperplasia, Focal | 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Dilatation | |
__________________________________________________________________________|
Ovary | M + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | 4 2 2 2 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Hyperplasia, Cystic | 1 2 2 2 1 4 2 1 3 3 2 1 1 2 4 4 2 2 1 3 1|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hemorrhage | |
Iliac, Inflammation, Chronic Active | |
Lumbar, Angiectasis | |
Lumbar, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 0| 5|
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M M M + + + M M + + M + M + M +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + M +|
Hemorrhage | 2 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + M + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 4 4 1 1 2 2 1 1 1 1 2 1 1 1 1 1|
Hyperplasia, Lymphoid | 2 2 3 |
Pigmentation, Hemosiderin | 1 1 1 1 2 3 2 2 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Thymus | + + + + + + M + + + + M + + + + + + + + + + + +|
Atrophy | 4 3 1 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia | 1 |
Sebaceous Gland, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 2 2 1 1 1 2 1 1 3 1 1|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 2 |
Hemorrhage | 2 4 |
Mineralization | 2 2 1 2 1 1 1 1 2 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 0| 5|
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 |
Respiratory Epithelium, Ulcer | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 1|
Nephropathy | 2 |
Renal Tubule, Dilatation | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 1 1 2 1 1 2 2 2 1 1|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 0| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + | 54 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Clear Cell Focus | | 2 |
Cytologic Alterations | | 1 2.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | | 1 4.0|
Inflammation, Chronic | | 6 1.0|
Inflammation, Chronic Active | | 4 1.0|
Mixed Cell Focus | | 1 |
Necrosis | | 2 2.0|
Hepatocyte, Necrosis | | 1 1.0|
Periportal, Fatty Change | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy | | 3 3.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Atrophy | | 1 1.0|
Inflammation, Chronic | 1 1 1 1 1 | 33 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 0| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Thrombosis | | 1 3.0|
Artery, Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Cyst | | 3 2.0|
Hypertrophy, Focal | | 2 1.0|
Subcapsular, Hyperplasia | 1 2 2 2 1 1 1 2 1 1 | 54 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + M + + + + + | 54 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 3 |
Hyperplasia, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + M + + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Cyst | | 1 2.0|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | | 12 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Ectopic Thymus | | 1 |
Inflammation, Chronic | | 3 1.7|
Follicle, Cyst | | 4 2.3|
Follicular Cell, Hyperplasia, Diffuse| | 1 4.0|
Follicular Cell, Hyperplasia, Focal | | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M | 2 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 55 |
Cyst | | 10 2.5|
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 58 |
Developmental Malformation | | 1 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2 | 50 1.9|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 0| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myeloid Cell, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Iliac, Hemorrhage | 2 | 1 2.0|
Iliac, Inflammation, Chronic Active | | 1 2.0|
Lumbar, Angiectasis | | 1 2.0|
Lumbar, Hemorrhage | | 1 4.0|
Renal, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + M + + | 40 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Hemorrhage | | 2 3.0|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + M + M + + | 52 |
Hyperplasia, Lymphoid | 4 | 3 3.3|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 1 1 1 1 3 1 1 1 1 1 | 54 1.4|
Hyperplasia, Lymphoid | 1 | 6 1.8|
Pigmentation, Hemosiderin | 2 1 2 2 2 1 1 2 2 | 46 1.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Atrophy | 2 3 | 5 2.6|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Dilatation | | 1 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 2 1.5|
Epithelium, Hyperplasia | | 2 1.0|
Sebaceous Gland, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 0| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Dysplasia | 1 | 25 1.3|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | | 4 2.3|
Hemorrhage | | 2 3.0|
Mineralization | 1 2 | 31 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | | 11 1.3|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 10 2.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Exudate, Serous | | 2 1.0|
Inflammation, Chronic Active | 1 1 | 12 1.1|
Olfactory Epithelium, Atrophy | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 5 1.0|
Olfactory Epithelium, Metaplasia | | 2 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 14 1.2|
Respiratory Epithelium, Hyperplasia | | 4 1.0|
Respiratory Epithelium, Ulcer | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 0| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Hydronephrosis | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 19 1.1|
Nephropathy | | 1 2.0|
Renal Tubule, Dilatation | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 24 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 8| 2| 2| 3| 9| 2| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 2| 0| 8| 2| 3| 3| 9|
| 9| 3| 9| 9| 0| 4| 9| 5| 0| 9| 0| 9| 9| 9| 4| 0| 9| 0| 9| 3| 5| 9| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + + + A A M + + +|
Dilatation | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + A + + + + + + + + + + + A A + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X |
Clear Cell Focus | |
Hemorrhage | 2 |
Hyperplasia | |
Infarct | 3 |
Inflammation, Chronic | 1 1 1 |
Mixed Cell Focus | |
Necrosis | 2 |
Pigmentation | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Acinus, Atrophy | 4 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 2 1 1 2 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Angiectasis | |
Developmental Malformation | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 3 1 1 2 2 2 3 2 2 1 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 8| 2| 2| 3| 9| 2| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 2| 0| 8| 2| 3| 3| 9|
| 9| 3| 9| 9| 0| 4| 9| 5| 0| 9| 0| 9| 9| 9| 4| 0| 9| 0| 9| 3| 5| 9| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + M + + + + + + + + M M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + M + + + M + + +|
Pars Distalis, Angiectasis | 1 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + |
Dilatation | |
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 1 1 2 |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 3 2 3 3 3 2 3 1 4 4 1 3 2 1 2 3 4 4 4 2 1 1 3 |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + +|
Iliac, Pigmentation | 2 |
Inguinal, Pigmentation | 2 |
Lumbar, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + M + + M + + M M M + M M + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + M + + M + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + A + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 3 1 1 |
Hyperplasia, Lymphoid | 2 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 8| 2| 2| 3| 9| 2| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 2| 0| 8| 2| 3| 3| 9|
| 9| 3| 9| 9| 0| 4| 9| 5| 0| 9| 0| 9| 9| 9| 4| 0| 9| 0| 9| 3| 5| 9| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 2 2 1 2 2 3 1 3 1 2 2 1 2 2 3 1 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Thymus | + + + + + M + M + + + + + M + + + + + + A M + + M|
Atrophy | 3 2 3 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
Hyperplasia | 3 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 2 2 2 2 1 2 1 1 1 1 2 1 1 |
Maxilla, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X 3 |
Hemorrhage | 2 |
Mineralization | 1 1 1 1 2 2 2|
Meninges, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + M + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 4 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | 2 1 1 1 1 1 1 1 1 2 |
Inflammation, Chronic Active | 1 2 2 1 1 1 |
Olfactory Epithelium, Atrophy | 2 2 2 1 1 1 |
Olfactory Epithelium, Degeneration, | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 8| 2| 2| 3| 9| 2| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 2| 0| 8| 2| 3| 3| 9|
| 9| 3| 9| 9| 0| 4| 9| 5| 0| 9| 0| 9| 9| 9| 4| 0| 9| 0| 9| 3| 5| 9| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyaline | |
Olfactory Epithelium, Metaplasia | 2 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 1 1 1 1 1 1 1 1|
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 1 1 |
Respiratory Epithelium, Ulcer | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 3 |
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 1 1 1 2 1 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + A A + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 2| 6| 3| 2| 7| 3| 1| 2| 2| 2| 1| 2| 4| 2| 3|
| 1| 1| 0| 0| 9| 0| 0| 9| 0| 1| 9| 5| 1| 9| 1| 1| 6| 9| 9| 9| 4| 9| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + A + + + M A + + + + + A + +|
Dilatation | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + A + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X |
Hemorrhage | |
Hyperplasia | 3 3|
Infarct | |
Inflammation, Chronic | 1 1 1 1 |
Mixed Cell Focus | X X |
Necrosis | |
Pigmentation | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Chronic | 1 1 1 2 2 1 3 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Developmental Malformation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 2| 6| 3| 2| 7| 3| 1| 2| 2| 2| 1| 2| 4| 2| 3|
| 1| 1| 0| 0| 9| 0| 0| 9| 0| 1| 9| 5| 1| 9| 1| 1| 6| 9| 9| 9| 4| 9| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | M M M + M M M + + M M M + + + + + + M M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 1 |
Pars Distalis, Hyperplasia | 2 1 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Dilatation | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 4 3 3 2 1 2 3|
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 1 3 4 1 1 1 2 1 3 2 4 4 4 1 3 2 3 4 4 3 2|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + +|
Iliac, Pigmentation | |
Inguinal, Pigmentation | |
Lumbar, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + M + M + + + M + M + M + + + M M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + M|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + A + + + + + + + A + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + M M + + + + M + M + + + + +|
Hyperplasia, Lymphoid | 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 2 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 2| 6| 3| 2| 7| 3| 1| 2| 2| 2| 1| 2| 4| 2| 3|
| 1| 1| 0| 0| 9| 0| 0| 9| 0| 1| 9| 5| 1| 9| 1| 1| 6| 9| 9| 9| 4| 9| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 3 2 2 2 2 1 1 1 1 2 1 2 1 2 3 1 1 1 1 2 1 1 3 2 |
__________________________________________________________________________|
Thymus | M M + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 2 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 3 1 2 2 4 1 2 2 2 1 |
Maxilla, Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
Mineralization | 2 1 3 2 1 2 2 1 2 1 2 1 2 1 2|
Meninges, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 2 1 1 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 2 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | 2 1 2 1 1 1 1 1 2 1 2 2 1|
Inflammation, Chronic Active | 1 1 |
Olfactory Epithelium, Atrophy | 1 2 2 1 1 2 1 2 2 1|
Olfactory Epithelium, Degeneration, | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 2| 6| 3| 2| 7| 3| 1| 2| 2| 2| 1| 2| 4| 2| 3|
| 1| 1| 0| 0| 9| 0| 0| 9| 0| 1| 9| 5| 1| 9| 1| 1| 6| 9| 9| 9| 4| 9| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyaline | 1 1 1 |
Olfactory Epithelium, Metaplasia | |
Olfactory Epithelium, Metaplasia, | |
Squamous | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
Respiratory Epithelium, Ulcer | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Infarct | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1|
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia, Focal | 4 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 1 2 1 1 2 1 1 1 2 1 3 2 1|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 51 |
Dilatation | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Hemorrhage | | 1 2.0|
Hyperplasia | | 2 3.0|
Infarct | | 1 3.0|
Inflammation, Chronic | | 7 1.0|
Mixed Cell Focus | | 2 |
Necrosis | | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 3 2.0|
Acinus, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic | 1 1 1 | 32 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Developmental Malformation | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Artery, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Subcapsular, Hyperplasia | 2 2 1 2 1 1 1 2 2 | 53 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 3 |
Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Angiectasis | | 2 1.5|
Pars Distalis, Cyst | | 2 2.0|
Pars Distalis, Hyperplasia | | 7 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia, Focal | | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 5 |
Dilatation | | 1 2.0|
Pigmentation | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Cyst | 3 1 | 13 2.2|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Angiectasis | 2 | 1 2.0|
Hyperplasia, Cystic | 2 2 2 3 2 1 3 1 1 2 | 54 2.4|
__________________________________________________________________________|____________|
Vagina | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Iliac, Pigmentation | | 1 2.0|
Inguinal, Pigmentation | | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + M + + | 38 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 55 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 53 |
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 1 2 1 2 1 1 1 1 1 1 | 54 1.2|
Hyperplasia, Lymphoid | | 3 2.3|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 | 57 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 51 |
Atrophy | | 6 2.7|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | | 2 2.5|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 4 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Dysplasia | 1 2 1 | 28 1.6|
Maxilla, Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 2 3.0|
Hemorrhage | | 1 2.0|
Mineralization | 2 1 2 1 1 | 27 1.6|
Meninges, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 1 | 23 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 8 2.1|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate, Serous | | 23 1.3|
Inflammation, Chronic Active | 1 1 1 1 | 12 1.2|
Olfactory Epithelium, Atrophy | | 16 1.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 3 1.0|
Olfactory Epithelium, Metaplasia | | 2 1.5|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 | 19 1.2|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 6 1.2|
Respiratory Epithelium, Ulcer | | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Phthisis Bulbi | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Glomerulosclerosis | | 1 3.0|
Infarct | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 | 31 1.2|
Renal Tubule, Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia, Focal | | 1 4.0|
Renal Tubule, Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 34 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 6| 5| 5| 5| 5| 6| 9| 6| 5| 6| 5| 8| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + A + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + M + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X|
Clear Cell Focus | X |
Cytologic Alterations | |
Eosinophilic Focus | X |
Fatty Change, Focal | |
Infarct | 4 |
Necrosis | 1 |
Syncytial Alteration | 1 1 1 2 1 2 1 2|
Vacuolization Cytoplasmic | |
Centrilobular, Fatty Change | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 2 1 1 2 2 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + I + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 2 1 1 2 2 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Subcapsular, Hyperplasia | 3 4 1 1 1 1 2 1 1 2 2 1 1 3 1 1 4 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + I + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + +|
Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M M M M M M M M + M + + + M M|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 6| 5| 5| 5| 5| 6| 9| 6| 5| 6| 5| 8| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Dilatation | 4 4 4 2 3 4 4 3 4 4 |
Inflammation, Chronic Active | 4 2 1 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
Seminiferous Tubule, Degeneration | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M + M + + + + M + M M M M + M + M M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + M + M + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 3 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + + + + M + + + + + M + + + + + + M + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 3 1 2 1 3 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + + + M M + + + + + M + + + + + + + + + + + + +|
Atrophy | 1 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 6| 5| 5| 5| 5| 6| 9| 6| 5| 6| 5| 8| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Fat, Necrosis | |
Hair Follicle, Atrophy | |
Prepuce, Inflammation, Chronic Active| 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Callus | |
Maxilla, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 1 1 3 2 3 1 2 2 1 2 1 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active | 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1|
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydronephrosis | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 1 1 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 1 |
Nephropathy | 4 |
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 6| 5| 5| 5| 5| 6| 9| 6| 5| 6| 5| 8| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 2 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 1| 6| 7| 7| 7| 7| 5| 5| 5| 7| 4| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 0| 3| 0| 2| 2| 1| 2| 6| 7| 9| 2| 7| 2|
| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 5| 9| 6| 4| 5| 6| 1| 5| 3| 0| 4| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + A + + A + A A A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + A + A A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + A + + A A + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + A A A + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X |
Clear Cell Focus | X |
Cytologic Alterations | 3 2 4 |
Eosinophilic Focus | |
Fatty Change, Focal | 2 |
Infarct | 4 |
Necrosis | |
Syncytial Alteration | 2 1 1 3 |
Vacuolization Cytoplasmic | 1 |
Centrilobular, Fatty Change | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
Subcapsular, Hyperplasia | 2 1 1 2 2 2 1 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + M + + M M + + + M + + + M + + + M + M|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 1| 6| 7| 7| 7| 7| 5| 5| 5| 7| 4| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 0| 3| 0| 2| 2| 1| 2| 6| 7| 9| 2| 7| 2|
| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 5| 9| 6| 4| 5| 6| 1| 5| 3| 0| 4| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + M +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + +|
Dilatation | 4 3 4|
Inflammation, Chronic Active | 3 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
Seminiferous Tubule, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M M M + M + M M + + + M M + M + + M + M + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M + M + + + + + + + + + M + + M + M M + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + A + A + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 1 1 1 1 2 1 4 1 1 1 1 2 1 2 1 2 1|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +|
Atrophy | 2 3 3 1 1 2 3 3 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 1| 6| 7| 7| 7| 7| 5| 5| 5| 7| 4| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 0| 3| 0| 2| 2| 1| 2| 6| 7| 9| 2| 7| 2|
| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 5| 9| 6| 4| 5| 6| 1| 5| 3| 0| 4| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M + M M M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 1 |
Hair Follicle, Atrophy | 3 |
Prepuce, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Callus | 3 |
Maxilla, Fracture | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 2 1 3 2 2 2 2 3 3 3 2 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 1 |
Olfactory Epithelium, Metaplasia | 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydronephrosis | 1 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1|
Inflammation, Chronic Active | 4 |
Metaplasia, Osseous | |
Nephropathy | |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 1| 6| 7| 7| 7| 7| 5| 5| 5| 7| 4| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 0| 3| 0| 2| 2| 1| 2| 6| 7| 9| 2| 7| 2|
| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 5| 9| 6| 4| 5| 6| 1| 5| 3| 0| 4| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 3 4|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 3 |
Clear Cell Focus | | 2 |
Cytologic Alterations | | 3 3.0|
Eosinophilic Focus | | 1 |
Fatty Change, Focal | | 1 2.0|
Infarct | | 2 4.0|
Necrosis | | 1 1.0|
Syncytial Alteration | | 12 1.5|
Vacuolization Cytoplasmic | | 1 1.0|
Centrilobular, Fatty Change | 1 1 1 2 | 5 1.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 3 1.0|
Acinus, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 1 1 1 | 36 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Dysplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hypertrophy, Focal | | 6 1.7|
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Subcapsular, Hyperplasia | 1 1 1 1 | 33 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 5 |
Hyperplasia, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + | 56 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia, Focal | | 8 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 19 |
Dilatation | 3 4 4 | 16 3.6|
Inflammation, Chronic Active | | 6 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 4 2.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Spermatocele | X | 1 |
Seminiferous Tubule, Degeneration | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myeloid Cell, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + M + | 33 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 49 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Hemorrhage | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M + + M + + + | 48 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 | 59 1.2|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 | 34 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Atrophy | | 13 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
Fat, Necrosis | | 1 1.0|
Hair Follicle, Atrophy | | 1 3.0|
Prepuce, Inflammation, Chronic Active| | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Maxilla, Callus | | 1 3.0|
Maxilla, Fracture | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 1 1 3 1 | 41 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic Active | | 3 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 8 1.1|
Olfactory Epithelium, Metaplasia | | 3 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 4 1.0|
Respiratory Epithelium, Hyperplasia | 1 | 13 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 2.0|
Hydronephrosis | | 2 1.0|
Infiltration Cellular, Lymphocyte | | 17 1.1|
Inflammation, Chronic Active | | 1 4.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | | 1 4.0|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
Renal Tubule, Regeneration | | 12 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | 3 | 7 3.1|
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
Inflammation, Chronic Active | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 3| 6|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 9| 2| 8| 2| 2| 7| 1|
| 5| 6| 5| 5| 1| 5| 9| 9| 5| 4| 4| 5| 5| 5| 5| 9| 5| 7| 2| 6| 1| 5| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + A + + + + + + + M + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + A A + + + + + +|
Proliferation Connective Tissue | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A A + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | |
Clear Cell Focus | X X |
Developmental Malformation | |
Hematopoietic Cell Proliferation | 1 |
Infarct | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Mixed Cell Focus | X |
Necrosis | 2 1 |
Proliferation Connective Tissue | |
Syncytial Alteration | 2 1 2 2 1 1 1 1 |
Centrilobular, Fatty Change | |
Midzonal, Fatty Change | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1 1 1 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 |
Hypertrophy, Focal | 1 1 2 1 1 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 3| 6|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 9| 2| 8| 2| 2| 7| 1|
| 5| 6| 5| 5| 1| 5| 9| 9| 5| 4| 4| 5| 5| 5| 5| 9| 5| 7| 2| 6| 1| 5| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 2 1 2 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + M M + M + + + + M + + + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | M + + + + M + + + M + + + + + I + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Spermatocele | X |
__________________________________________________________________________|
Penis | +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Abscess | 4 |
Dilatation | 4 3 4 3 4 3 3 4 |
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 3 2 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 4|
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M + + + + + + + M + + + M M + M + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + A + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 3| 6|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 9| 2| 8| 2| 2| 7| 1|
| 5| 6| 5| 5| 1| 5| 9| 9| 5| 4| 4| 5| 5| 5| 5| 9| 5| 7| 2| 6| 1| 5| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + + + + + + + M + + + + + + M + M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 3 3|
Hyperplasia, Lymphoid | 2 2 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | 2 2 3 2 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M M M M M M A M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Ulcer | 3 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Cartilage, Degeneration | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 2 2 3 1 2 2 1 2 2 2 1 2 1 2|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 3| 6|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 9| 2| 8| 2| 2| 7| 1|
| 5| 6| 5| 5| 1| 5| 9| 9| 5| 4| 4| 5| 5| 5| 5| 9| 5| 7| 2| 6| 1| 5| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
Respiratory Epithelium, Ulcer | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Cyst | |
Hydronephrosis | 2 1|
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 1 1 |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 4 |
Nephropathy | 3 |
Renal Tubule, Dilatation | 1 1 |
Renal Tubule, Regeneration | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
Dilatation | 3 4 3 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 2 4|
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 9| 6| 2| 2| 2| 9| 2| 2| 2| 0| 8| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 8| 2| 2|
| 6| 9| 7| 5| 5| 6| 3| 6| 6| 6| 3| 4| 6| 6| 6| 2| 6| 5| 5| 6| 6| 6| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M M + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + M A A + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + A A + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + A + + + + + + + + + + + + +|
Proliferation Connective Tissue | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + A A + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Clear Cell Focus | X |
Developmental Malformation | X |
Hematopoietic Cell Proliferation | |
Infarct | 4 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | X X X |
Necrosis | 2 |
Proliferation Connective Tissue | X |
Syncytial Alteration | 1 2 1 1 1 1 |
Centrilobular, Fatty Change | 2 1 1 |
Midzonal, Fatty Change | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hypertrophy, Focal | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 9| 6| 2| 2| 2| 9| 2| 2| 2| 0| 8| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 8| 2| 2|
| 6| 9| 7| 5| 5| 6| 3| 6| 6| 6| 3| 4| 6| 6| 6| 2| 6| 5| 5| 6| 6| 6| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Subcapsular, Hyperplasia | 1 1 2 1 1 2 1 2 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + |
Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Parathyroid Gland | + M M M M M + + + + + + + + + M + + + M + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 1 1 1 1 2 1 1 1 3 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Spermatocele | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
Abscess | 4 3 |
Dilatation | 4 3 4 4 4 3 |
Inflammation, Chronic Active | 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 3 3|
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + M + + + + M + + M + + + + M + + M M +|
Hemorrhage | 2|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 4 2 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 9| 6| 2| 2| 2| 9| 2| 2| 2| 0| 8| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 8| 2| 2|
| 6| 9| 7| 5| 5| 6| 3| 6| 6| 6| 3| 4| 6| 6| 6| 2| 6| 5| 5| 6| 6| 6| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + M M + + + + + + + M M + + M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 3 2 1 1 1 2 1 1 1 1 3 1 1|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + M + + + + M + + +|
Atrophy | 3 1 4 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 4|
Ulcer | 4|
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
Cartilage, Degeneration | 3|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 1 2 2 2 2 1 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 9| 6| 2| 2| 2| 9| 2| 2| 2| 0| 8| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 8| 2| 2|
| 6| 9| 7| 5| 5| 6| 3| 6| 6| 6| 3| 4| 6| 6| 6| 2| 6| 5| 5| 6| 6| 6| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
Respiratory Epithelium, Ulcer | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cyst | 1 |
Hydronephrosis | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1|
Inflammation, Acute | |
Inflammation, Chronic Active | 1 4 |
Nephropathy | |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
Dilatation | 3 4 2 2|
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 55 |
Proliferation Connective Tissue | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 4.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 3 |
Developmental Malformation | | 1 |
Hematopoietic Cell Proliferation | | 1 1.0|
Infarct | | 2 3.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Mixed Cell Focus | X | 5 |
Necrosis | | 3 1.7|
Proliferation Connective Tissue | | 1 |
Syncytial Alteration | | 14 1.3|
Centrilobular, Fatty Change | 1 1 1 | 6 1.2|
Midzonal, Fatty Change | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 33 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Cyst | 3 | 3 2.0|
Hypertrophy, Focal | 1 1 1 | 16 1.3|
Subcapsular, Hyperplasia | 1 | 26 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 3 |
Hyperplasia, Focal | 2 | 3 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + M + + + + | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 56 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia, Focal | | 17 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 2 2.5|
Spermatocele | | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 22 |
Abscess | | 3 3.7|
Dilatation | | 14 3.6|
Inflammation, Chronic Active | | 6 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 7 2.3|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myeloid Cell, Hyperplasia | | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + | 45 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + | 57 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 4 2.5|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 1 1 1 1 | 53 1.3|
Hyperplasia, Lymphoid | | 2 2.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 | 26 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Atrophy | | 12 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M + + | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 3 3.0|
Ulcer | | 2 3.5|
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 1 2.0|
Cartilage, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 2 1 2 1 | 36 1.7|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 3 1.7|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 4 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 8 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 4 1.0|
Olfactory Epithelium, Metaplasia | | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 3 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 | 20 1.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 1.0|
Respiratory Epithelium, Ulcer | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 2.0|
Cyst | | 1 1.0|
Hydronephrosis | | 2 1.5|
Infiltration Cellular, Lymphocyte | | 18 1.1|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | | 3 3.0|
Nephropathy | | 1 3.0|
Renal Tubule, Dilatation | 1 | 3 1.0|
Renal Tubule, Regeneration | 1 | 6 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Dilatation | | 7 3.0|
Infiltration Cellular, Lymphocyte | 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic Active | | 3 3.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 5| 6| 5| 2| 2| 2| 2|
| 6| 6| 6| 4| 6| 4| 6| 7| 6| 6| 6| 8| 5| 6| 9| 6| 5| 6| 8| 2| 8| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + M + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Cytologic Alterations | X 2 |
Eosinophilic Focus | X |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 3 |
Infarct | 4 4 |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis | |
Syncytial Alteration | 1 1 1 2 2 1 2 |
Bile Duct, Cyst | 3 3 |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Fatty Change | |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation, Chronic Active | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 5| 6| 5| 2| 2| 2| 2|
| 6| 6| 6| 4| 6| 4| 6| 7| 6| 6| 6| 8| 5| 6| 9| 6| 5| 6| 8| 2| 8| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 |
Hypertrophy, Focal | 1 1 3 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
Subcapsular, Hyperplasia | 1 1 1 2 1 1 1 3 4 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Hyperplasia, Focal | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M M M + + M + M + + + + + + + + + + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + I + + + + + + + + + + + + + M + + +|
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia, Focal | 1 1 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Abscess | 4 2 |
Dilatation | 4 4 4 4 3 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 4 4 4 4|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Tunic, Inflammation, Chronic | 2 |
Tunic, Proliferation Connective | |
Tissue | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 5| 6| 5| 2| 2| 2| 2|
| 6| 6| 6| 4| 6| 4| 6| 7| 6| 6| 6| 8| 5| 6| 9| 6| 5| 6| 8| 2| 8| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 4 3 2|
__________________________________________________________________________|
Lymph Node | + + +|
Iliac, Infiltration Cellular, | |
Histiocyte | 2 |
Inguinal, Hyperplasia, Lymphoid | 2 2|
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M + + M M M + + + M M M M M M + M M M +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 4 2 2 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + M + + + M + M + M M + + + + + + + + + M|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 1 2 1 1 1 1 1 1 3 1 1 1 1 1 1 1 3 2 1 1 1 2|
Hematopoietic Cell Proliferation | |
Granulocytic | 4 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + + M + + + M + M + + + + + + + + + M + M + + +|
Atrophy | 2 3 3 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 4|
Epithelium, Hyperplasia | 1 |
Prepuce, Inflammation, Chronic Active| 4 |
Prepuce, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Dysplasia | |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 5| 6| 5| 2| 2| 2| 2|
| 6| 6| 6| 4| 6| 4| 6| 7| 6| 6| 6| 8| 5| 6| 9| 6| 5| 6| 8| 2| 8| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization | 1 2 1 2 1 2 1 1 2 3 3 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 |
Inflammation, Chronic Active | 2 1 1 1 1|
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | X |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Infarct | 1 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 |
Inflammation, Chronic Active | 3 4 |
Metaplasia, Osseous | |
Mineralization | 1 |
Artery, Inflammation, Chronic Active | 2 |
Renal Tubule, Hyperplasia, Focal | 3 2 |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 2 2 3 4 4 3|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | 3 4 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 4| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 7| 2| 8| 2| 2| 2| 0| 2| 2| 8| 2| 4| 1|
| 5| 5| 1| 9| 5| 5| 6| 6| 3| 6| 6| 5| 9| 6| 4| 5| 6| 5| 7| 6| 6| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + A M + + + + A + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + A + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X |
Cytologic Alterations | |
Eosinophilic Focus | |
Fatty Change, Focal | 2 |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis | 1 3 |
Syncytial Alteration | 1 1 1 1 1 1 2 1 1 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | |
Centrilobular, Fatty Change | |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 4| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 7| 2| 8| 2| 2| 2| 0| 2| 2| 8| 2| 4| 1|
| 5| 5| 1| 9| 5| 5| 6| 6| 3| 6| 6| 5| 9| 6| 4| 5| 6| 5| 7| 6| 6| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
Hypertrophy, Focal | 2 2 1 2 1 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Subcapsular, Hyperplasia | 1 1 1 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Focal | 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
Hyperplasia, Focal | 2 2 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + M M + M M M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia, Focal | 3 1 4 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Penis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + +|
Abscess | |
Dilatation | 4 3 4 3 3 1 3|
Inflammation, Chronic Active | 2 2 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 3 4 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Tunic, Inflammation, Chronic | |
Tunic, Proliferation Connective | |
Tissue | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 4| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 7| 2| 8| 2| 2| 2| 0| 2| 2| 8| 2| 4| 1|
| 5| 5| 1| 9| 5| 5| 6| 6| 3| 6| 6| 5| 9| 6| 4| 5| 6| 5| 7| 6| 6| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Infiltration Cellular, | |
Histiocyte | |
Inguinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M M + M + + M M + M + + + M M + M + M + M M|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +|
Angiectasis | 1 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + M + A M + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 3 2 4 1 1 1 3 3|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + M A + + + M M M + + + +|
Atrophy | 4 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | |
Prepuce, Inflammation, Chronic Active| |
Prepuce, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Dysplasia | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 4| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 7| 2| 8| 2| 2| 2| 0| 2| 2| 8| 2| 4| 1|
| 5| 5| 1| 9| 5| 5| 6| 6| 3| 6| 6| 5| 9| 6| 4| 5| 6| 5| 7| 6| 6| 1| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization | 1 1 1 2 2 2 1 2 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Inflammation, Chronic Active | 1 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1|
Olfactory Epithelium, Metaplasia | 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infarct | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 |
Inflammation, Chronic Active | 4 4 4 |
Metaplasia, Osseous | 1 |
Mineralization | |
Artery, Inflammation, Chronic Active | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
Dilatation | 4 4 2 2 4 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | 4 3 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
75 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M + + + + + M + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 |
Clear Cell Focus | | 3 |
Cytologic Alterations | | 2 2.0|
Eosinophilic Focus | | 1 |
Fatty Change, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Infarct | | 3 4.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Mixed Cell Focus | X | 1 |
Necrosis | 1 | 3 1.7|
Syncytial Alteration | | 16 1.3|
Bile Duct, Cyst | | 2 3.0|
Bile Duct, Hyperplasia | | 1 1.0|
Centrilobular, Fatty Change | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Artery, Inflammation, Chronic Active | | 1 3.0|
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 3.0|
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 1 1 1 1 | 29 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Necrosis | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
75 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Cyst | | 1 2.0|
Hyperplasia | | 1 3.0|
Hypertrophy, Focal | | 10 1.5|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
Subcapsular, Hyperplasia | 1 1 | 18 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 9 |
Hyperplasia, Focal | | 7 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + M + + + + + | 54 |
Pars Distalis, Hyperplasia, Focal | | 1 1.0|
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | X | 1 |
Follicular Cell, Hyperplasia, Focal | | 12 1.4|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 18 |
Abscess | | 2 3.0|
Dilatation | 2 4 4 2 | 17 3.2|
Inflammation, Chronic Active | | 5 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia, Focal | | 1 3.0|
Inflammation, Chronic Active | | 4 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
75 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | | 12 3.3|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Mineralization | | 1 2.0|
Tunic, Inflammation, Chronic | | 1 2.0|
Tunic, Proliferation Connective | | |
Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myeloid Cell, Hyperplasia | | 7 2.9|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Iliac, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 2 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + M + + + + | 26 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Angiectasis | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 5 2.4|
Hyperplasia, Plasma Cell | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + | 48 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 4 | 57 1.4|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 4.0|
Pigmentation, Hemosiderin | 2 1 1 1 1 1 1 2 2 | 55 1.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 48 |
Atrophy | 2 | 7 2.7|
Hyperplasia, Lymphoid | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M M M M | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
75 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 2 4.0|
Epithelium, Hyperplasia | | 1 1.0|
Prepuce, Inflammation, Chronic Active| | 1 4.0|
Prepuce, Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Dysplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 2 3 1 1 1 2 2 | 31 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 7 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 1 1.0|
Inflammation, Chronic Active | | 7 1.1|
Olfactory Epithelium, Atrophy | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 2 1.0|
Olfactory Epithelium, Metaplasia | | 3 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 3 1.3|
Respiratory Epithelium, Hyperplasia | 1 | 19 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
75 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Phthisis Bulbi | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 2.5|
Infarct | | 2 1.0|
Infiltration Cellular, Lymphocyte | 1 1 | 13 1.1|
Inflammation, Chronic Active | | 5 3.8|
Metaplasia, Osseous | | 1 1.0|
Mineralization | | 1 1.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Renal Tubule, Hyperplasia, Focal | | 2 2.5|
Renal Tubule, Regeneration | 1 | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | | 14 3.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Chronic Active | | 5 3.4|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 5| 7| 4| 7| 5| 6| 7| 7| 7| 5| 7| 5| 2| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 4| 2| 2| 7| 2| 4| 2| 5| 6| 2| 2| 2| 5| 2| 4| 3| 2| 8| 2| 2| 2| 2|
| 5| 5| 6| 0| 5| 6| 5| 5| 3| 5| 3| 8| 5| 5| 5| 8| 6| 1| 5| 4| 8| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + A + + + + + A A + A + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + A + + A + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A + + A + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + A + A + + A + + M + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + A + + A + + + + + A A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Basophilic Focus | X X |
Cytologic Alterations | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Infarct | 3 3 |
Inflammation, Chronic | 1 1 1 1|
Mixed Cell Focus | |
Necrosis | 2 3 3 2 |
Proliferation Connective Tissue | |
Syncytial Alteration | 1 1 1 1 1|
Bile Duct, Hyperplasia | |
Centrilobular, Fatty Change | |
Centrilobular, Necrosis | 2 2 |
Hepatocyte, Necrosis | 1 |
Periportal, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + A A + + + + + +|
Inflammation, Chronic | 1 1 |
Proliferation Connective Tissue | |
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 2 1 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + A A + + + + + +|
Dysplasia | |
Necrosis | 1 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 5| 7| 4| 7| 5| 6| 7| 7| 7| 5| 7| 5| 2| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 4| 2| 2| 7| 2| 4| 2| 5| 6| 2| 2| 2| 5| 2| 4| 3| 2| 8| 2| 2| 2| 2|
| 5| 5| 6| 0| 5| 6| 5| 5| 3| 5| 3| 8| 5| 5| 5| 8| 6| 1| 5| 4| 8| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration | 1 |
Thrombosis | 2 |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + A + + + + M + + + + + + + + + + +|
Hypertrophy, Focal | 1 1 1 1 |
Subcapsular, Hyperplasia | 2 1 1 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + A + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + M + M M + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M M + + + + M + + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 3 3 1 1 2 2 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | A |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 4 2 2 |
__________________________________________________________________________|
Penis | + + |
Congestion | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Abscess | 3|
Dilatation | 4 4 4 2 4 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 |
Hyperplasia | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
Infarct | 3 |
Myeloid Cell, Hyperplasia | 3 3 2|
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 5| 7| 4| 7| 5| 6| 7| 7| 7| 5| 7| 5| 2| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 4| 2| 2| 7| 2| 4| 2| 5| 6| 2| 2| 2| 5| 2| 4| 3| 2| 8| 2| 2| 2| 2|
| 5| 5| 6| 0| 5| 6| 5| 5| 3| 5| 3| 8| 5| 5| 5| 8| 6| 1| 5| 4| 8| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Inflammation, Chronic Active | |
Inguinal, Inflammation, Chronic | |
Active | |
Inguinal, Pigmentation | 2 |
Lumbar, Hemorrhage | |
Lumbar, Hyperplasia, Histiocytic | |
Lumbar, Hyperplasia, Lymphoid | 3 |
Lumbar, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M + + + + M + M + + M + + M M + + + M|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + M + + + + + + + + M + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + + A A + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + M M + + + M + M + + + + + M M + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + A + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 1 1 1 1 1 2 1 3 3 2 1 2 1 3 1 1 3 3 1 1 4|
Hematopoietic Cell Proliferation | |
Granulocytic | 3 3 |
Pigmentation, Hemosiderin | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 2 1 1 1 2 1|
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + M + A + M + + + + M|
Atrophy | 2 3 3 2 |
Cyst | 2 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 4 4 |
Ulcer | 4 |
Prepuce, Inflammation, Chronic Active| |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 5| 7| 4| 7| 5| 6| 7| 7| 7| 5| 7| 5| 2| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 4| 2| 2| 7| 2| 4| 2| 5| 6| 2| 2| 2| 5| 2| 4| 3| 2| 8| 2| 2| 2| 2|
| 5| 5| 6| 0| 5| 6| 5| 5| 3| 5| 3| 8| 5| 5| 5| 8| 6| 1| 5| 4| 8| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Granuloma | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 1 1 1 2 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + M + + + M + I + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Lymphocyte | |
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | 1 |
Inflammation, Chronic Active | 1 1 1 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Ulcer | |
__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
Cornea, Inflammation, Chronic Active | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 5| 7| 4| 7| 5| 6| 7| 7| 7| 5| 7| 5| 2| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 4| 2| 2| 7| 2| 4| 2| 5| 6| 2| 2| 2| 5| 2| 4| 3| 2| 8| 2| 2| 2| 2|
| 5| 5| 6| 0| 5| 6| 5| 5| 3| 5| 3| 8| 5| 5| 5| 8| 6| 1| 5| 4| 8| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | 2 2 |
Hydronephrosis | 2 |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 2 1 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 4 3 2|
Renal Tubule, Dilatation | 2 2 1 |
Renal Tubule, Hyperplasia, Focal | 1 1 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
Dilatation | 4 3 3 4 3 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 4 3|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 1| 5| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 5| 1| 1| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 9| 2| 2| 2| 0| 5| 2| 2| 3|
| 5| 5| 5| 8| 8| 6| 5| 9| 5| 5| 6| 5| 3| 2| 5| 6| 2| 5| 5| 6| 0| 6| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + A + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + A + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Basophilic Focus | |
Cytologic Alterations | 3 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 4 |
Infarct | |
Inflammation, Chronic | 2 |
Mixed Cell Focus | X |
Necrosis | |
Proliferation Connective Tissue | X |
Syncytial Alteration | 1 1 1 2 1 2 |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Fatty Change | |
Centrilobular, Necrosis | |
Hepatocyte, Necrosis | |
Periportal, Vacuolization Cytoplasmic| 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Proliferation Connective Tissue | X |
Acinus, Atrophy | 1 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 |
Necrosis | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 1| 5| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 5| 1| 1| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 9| 2| 2| 2| 0| 5| 2| 2| 3|
| 5| 5| 5| 8| 8| 6| 5| 9| 5| 5| 6| 5| 3| 2| 5| 6| 2| 5| 5| 6| 0| 6| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration | |
Thrombosis | |
Artery, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 2 1 1 1 1 |
Subcapsular, Hyperplasia | 2 1 1 2 2 1 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + M + + + M M + M + M + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 2 1 |
__________________________________________________________________________|
Penis | + +|
Congestion | |
Inflammation, Chronic Active | 4 4|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | |
Dilatation | 4 4 4 4 4 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 1 3 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Myeloid Cell, Hyperplasia | 4 3 3 3|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 1| 5| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 5| 1| 1| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 9| 2| 2| 2| 0| 5| 2| 2| 3|
| 5| 5| 5| 8| 8| 6| 5| 9| 5| 5| 6| 5| 3| 2| 5| 6| 2| 5| 5| 6| 0| 6| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Inflammation, Chronic Active | 3 |
Inguinal, Inflammation, Chronic | |
Active | 3 |
Inguinal, Pigmentation | |
Lumbar, Hemorrhage | 2 |
Lumbar, Hyperplasia, Histiocytic | 2 |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + M + + M + + + M + + M M M + M M + + + +|
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 2 2 3|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + + + M M + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 1 1 1 2 4 1 1 1 1 1 3 2 1 2 4 1 1 1 2 3 1 1 3|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Pigmentation, Hemosiderin | 1 1 1 2 2 2 1 1 1 1 1 2 2 3 1 1 1 2 1 1 2 2 1 1 2|
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + M + M + + + + + M + + + + + + + + + M + + + +|
Atrophy | 2 2 3 3 2 |
Cyst | |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Ulcer | 3 |
Prepuce, Inflammation, Chronic Active| 4 |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 1| 5| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 5| 1| 1| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 9| 2| 2| 2| 0| 5| 2| 2| 3|
| 5| 5| 5| 8| 8| 6| 5| 9| 5| 5| 6| 5| 3| 2| 5| 6| 2| 5| 5| 6| 0| 6| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Granuloma | 3 |
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Lymphocyte | 1 1 1 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 1 3 2 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 |
Respiratory Epithelium, Ulcer | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Phthisis Bulbi | X |
Cornea, Inflammation, Chronic Active | 3 |
Lens, Cataract | 1 |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 1| 5| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 5| 1| 1| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 9| 2| 2| 2| 0| 5| 2| 2| 3|
| 5| 5| 5| 8| 8| 6| 5| 9| 5| 5| 6| 5| 3| 2| 5| 6| 2| 5| 5| 6| 0| 6| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | |
Hydronephrosis | 2 4 1 2 |
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 3 1 1 1 1 1 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 4 4|
Renal Tubule, Dilatation | 2 1 3 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Regeneration | 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Dilatation | 4 3 3 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 4 4 3 4 4|
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 3| 0| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 0| 9| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 53 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + A + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + A + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Abscess | | 1 2.0|
Basophilic Focus | | 2 |
Cytologic Alterations | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | | 1 4.0|
Infarct | | 2 3.0|
Inflammation, Chronic | | 5 1.2|
Mixed Cell Focus | | 1 |
Necrosis | | 4 2.5|
Proliferation Connective Tissue | | 1 |
Syncytial Alteration | | 11 1.2|
Bile Duct, Hyperplasia | | 1 2.0|
Centrilobular, Fatty Change | 1 | 1 1.0|
Centrilobular, Necrosis | | 2 2.0|
Hepatocyte, Necrosis | | 1 1.0|
Periportal, Vacuolization Cytoplasmic| | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + | 56 |
Inflammation, Chronic | | 3 1.0|
Proliferation Connective Tissue | | 1 |
Acinus, Atrophy | | 1 1.0|
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 29 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + | 56 |
Dysplasia | | 1 2.0|
Necrosis | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 3| 0| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 0| 9| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 1.0|
Degeneration | | 1 1.0|
Thrombosis | | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Hypertrophy, Focal | | 9 1.1|
Subcapsular, Hyperplasia | 1 1 1 1 1 | 24 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia, Focal | | 20 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 8 2.6|
__________________________________________________________________________|____________|
Penis | + | 5 |
Congestion | 3 | 1 3.0|
Inflammation, Chronic Active | | 3 3.3|
__________________________________________________________________________|____________|
Preputial Gland | + + | 14 |
Abscess | | 1 3.0|
Dilatation | 3 | 11 3.7|
Inflammation, Chronic Active | 1 | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 3| 0| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 0| 9| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | | 3 3.0|
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Seminiferous Tubule, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Infarct | | 1 3.0|
Myeloid Cell, Hyperplasia | 4 2 | 9 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Iliac, Inflammation, Chronic Active | | 1 3.0|
Inguinal, Inflammation, Chronic | | |
Active | | 1 3.0|
Inguinal, Pigmentation | | 1 2.0|
Lumbar, Hemorrhage | | 1 2.0|
Lumbar, Hyperplasia, Histiocytic | | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + M M | 39 |
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + + + + | 56 |
Hemorrhage | | 6 2.2|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M + M + | 46 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 3 1 3 1 1 2 1 1 1 1 | 55 1.7|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 3.0|
Pigmentation, Hemosiderin | 2 2 1 2 1 1 1 2 2 | 56 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 3| 0| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 0| 9| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoid Follicle, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 50 |
Atrophy | | 9 2.4|
Cyst | | 1 2.0|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | | 3 4.0|
Ulcer | | 2 3.5|
Prepuce, Inflammation, Chronic Active| | 1 4.0|
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Granuloma | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fracture | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 1 1 | 24 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 3 1.0|
Leukocytosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 13 2.1|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate, Serous | | 2 1.0|
Inflammation, Chronic Active | | 10 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05185-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:58:02
__________________________________________________________________________________________________________________________________
| 3| 0| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 0| 9| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 2 1.0|
Olfactory Epithelium, Metaplasia | | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 3 1.0|
Respiratory Epithelium, Hyperplasia | | 8 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 1.3|
Respiratory Epithelium, Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Phthisis Bulbi | | 1 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
Lens, Cataract | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Cyst | | 2 2.0|
Hydronephrosis | | 5 2.2|
Infarct | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 23 1.3|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic Active | 4 | 6 3.5|
Renal Tubule, Dilatation | | 6 1.8|
Renal Tubule, Hyperplasia, Focal | | 2 1.0|
Renal Tubule, Regeneration | | 4 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + | 57 |
Dilatation | 2 | 9 3.2|
Infiltration Cellular, Lymphocyte | | 5 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 | 8 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
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---------- END OF REPORT ----------
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