TDMS Study 05185-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IITRI ISOBUTYL NITRITE (IBN) DATE: 05/20/95
EXPERIMENT: 05185 TEST: 04 TIME: 11:45:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01 ES 65143 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61052B
PATHOLOGIST: RICHARD LONG CAS: 542-56-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IITRI ISOBUTYL NITRITE (IBN) DATE: 05/20/95
EXPERIMENT: 05185 TEST: 04 TIME: 11:45:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01 ES 65143 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61052B
PATHOLOGIST: RICHARD LONG CAS: 542-56-3
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 725 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 12 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 136 455 479 509 512 529 563 594 604 618 |
| 711 |
| CENSORED DEATHS |
| 61 457 457 457 457 457 457 457 457 457 |
| 457 570 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 37.5 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 124 379 561 581 614 667 667 682 684 687 |
| 692 693 699 703 724 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 307 408 484 557 558 558 564 579 583 614 |
| 619 647 662 681 701 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 725 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 150 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 9 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 96 296 300 316 443 534 541 552 553 556 |
| 558 558 575 588 625 640 668 692 693 718 |
| 724 |
| CENSORED DEATHS |
| 100 235 457 457 457 457 457 457 457 |
| |
==================================================================================
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 725 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 725 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.3 98.3 98.3 98.3 94.6 88.4 82.1 80.0 77.9 |
| | |
| | |
|37.5 PPM | 100.0 98.3 98.3 98.3 96.7 96.7 96.7 92.6 90.6 70.5 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 98.3 96.7 94.7 94.7 82.6 74.5 70.5 |
| | |
| | |
|150 PPM | 100.0 98.3 98.3 93.2 93.2 91.4 87.5 73.5 69.6 59.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 37.5 PPM 75 PPM 150 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 77.9% 70.5% 70.5% 59.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.047 P=0.677 P=0.599 P=0.083 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 519.1 610.5 568.1 534.6 |
|NATURAL DEATHS (C) | (44.1) (41.4) (26.9) (35.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 628.9 651.7 641.1 608.5 |
|(STANDARD ERROR) | (19.2) (16.4) (15.2) (21.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 9 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 71 91 572 576 585 589 595 613 635 638 |
| 643 649 689 690 691 691 696 709 709 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 37.5 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 9 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 183 512 520 586 614 645 697 707 728 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 14 CENSORED DEATHS 9 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 210 415 434 460 558 558 585 628 636 639 |
| 660 663 706 719 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 |
| |
==================================================================================
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 150 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 11 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 71 114 485 494 583 603 625 646 692 716 |
| 721 724 |
| CENSORED DEATHS |
| 65 458 458 458 458 458 458 458 458 458 |
| 458 |
| |
==================================================================================
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.3 96.7 96.7 96.7 96.7 96.7 96.7 86.8 76.9 63.1 |
| | |
| | |
|37.5 PPM | 100.0 100.0 98.3 98.3 98.3 98.3 94.4 92.4 88.5 82.6 |
| | |
| | |
|75 PPM | 100.0 100.0 98.3 98.3 96.6 92.9 92.9 86.8 76.7 72.7 |
| | |
| | |
|150 PPM | 98.3 96.6 96.6 96.6 96.6 94.6 92.5 88.4 84.3 76.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 37.5 PPM 75 PPM 150 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.1% 82.6% 72.7% 76.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.452N P=0.045N P=0.494N P=0.238N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 585.9 576.9 562.2 539.5 |
|NATURAL DEATHS (C) | (42.2) (55.6) (37.3) (64.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 643.0 665.5 648.1 634.9 |
|(STANDARD ERROR) | (18.5) (15.5) (16.4) (21.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ISOBUTYL NITRITE (IBN)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
37.5 PPM = 2
75 PPM = 3
150 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1 3
| 4 2 1 43 2 3 1
|
| 2 3 1 13 2
95 + 4 4 13 1 32 2
| 4 4
| 11 2 2
| 4 4 2 2
P 90 + 1 144
E | 1 31
R | 44
C | 1 3 1 2 2
E 85 + 33
N | 44 1 1
T | 3 131 22
|
S 80 + 31 1
U | 3 3
R | 4 4 1 1
V | 3 3 22
I 75 + 44 3 3 22
V | 4 4
A | 3 2 2
L | 4 4
70 + 4 4 3 2
|
| 4 4
|
65 +
| 4 4
|
| 44
60 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
ISOBUTYL NITRITE (IBN)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
37.5 PPM = 2
75 PPM = 3
150 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 1 4 2 3 3 2
|
| 1 4 3 3 4 2 2 1
95 + 3 3 44 2 112
|
| 3 4 3 11 2
| 1 1
P 90 + 4 42 2
E | 3 3 4 4 2 2
R |
C | 3 1 1 3 4 22
E 85 + 1 31 2 2
N | 4 4
T | 11 4 42 2
| 3 3
S 80 +
U | 11
R | 1 1 44
V | 3 3 4 4
I 75 + 3 3
V |
A | 3 3
L |
70 +
| 11
| 1 1
|
65 +
| 1 1
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.