TDMS Study 05185-03 Pathology Tables
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
Facility: I. I. T. Research Institute
Chemical CAS #: 542-56-3
Lock Date: 05/22/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 0| 1| 4| 5| 3| 3| 4| 7| 3| 3| 3| 0| 3|
| 3| 4| 3| 3| 4| 2| 8| 4| 5| 3| 5| 4| 2| 6| 1| 8| 5| 4| 6| 1| 5| 5| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Basophilic Focus, Multiple | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1|
Clear Cell Focus | |
Congestion | |
Developmental Malformation | 2 |
Eosinophilic Focus | |
Fatty Change | 4 2 2 2 1 3 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X |
Inflammation | 1 |
Mixed Cell Focus | |
Necrosis | 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Acinar Cell, Atrophy | 1 2 1 1 2 2 2 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Ulcer | 3 1 |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer | 3 2 |
Ulcer, Multiple | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 |
Atrium, Thrombosis | 3 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 0| 1| 4| 5| 3| 3| 4| 7| 3| 3| 3| 0| 3|
| 3| 4| 3| 3| 4| 2| 8| 4| 5| 3| 5| 4| 2| 6| 1| 8| 5| 4| 6| 1| 5| 5| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Cyst | 3 |
Degeneration | |
Hemorrhage | |
Hyperplasia | 1 1 |
Hypertrophy | 1 |
Necrosis | |
Vacuolization Cytoplasmic | 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + M + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 |
Hyperplasia | 3 |
Pars Distalis, Angiectasis | 1 3 4 2|
Pars Distalis, Cyst | 2 2 3 2 2 2 2 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 2|
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1 2 3 3 2 3 2 3 2 3 2|
Hyperplasia | 2 2 |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Corpus Luteum, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
Bilateral, Dilatation | 2 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 0| 1| 4| 5| 3| 3| 4| 7| 3| 3| 3| 0| 3|
| 3| 4| 3| 3| 4| 2| 8| 4| 5| 3| 5| 4| 2| 6| 1| 8| 5| 4| 6| 1| 5| 5| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 3 4 |
__________________________________________________________________________|
Lymph Node | |
Lumbar, Cyst | |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M M M + M M + + M M + M + + M M + M M + M|
Hemorrhage | 3 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 1 3 2 1 1 3 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + M + + + + + + + + + + +|
Hemorrhage | 2 1 3 1 2 2 3 3 2 3 1 1 2 3 2 2|
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 1 2 2 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 4 4 2 4 2 3 2 4 4 3 1 2 1 3 3 |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lactation | 2 1 3 2 2 3 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tail, Hyperkeratosis | |
Tail, Parakeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 1 2 2 3 3 |
Hemorrhage | |
Hydrocephalus | 3 1 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 0| 1| 4| 5| 3| 3| 4| 7| 3| 3| 3| 0| 3|
| 3| 4| 3| 3| 4| 2| 8| 4| 5| 3| 5| 4| 2| 6| 1| 8| 5| 4| 6| 1| 5| 5| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation | 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 1 |
Inflammation | 2 2 1|
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 3 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | |
Respiratory Epithelium, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 3 |
Mineralization | 1 1 |
Nephropathy, Chronic | 2 1 2 1 2 1 2 1 3 2 3 2 1 2 2 2 2 2 1 1 1 2|
Pigmentation | 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 4| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 0| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 6| 3| 6| 2| 3| 3| 5| 5| 5| 5|
| 4| 5| 3| 6| 1| 3| 4| 4| 3| 5| 4| 3| 0| 3| 0| 6| 5| 4| 0| 4| 3| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Necrosis | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 1 1 1|
Basophilic Focus, Multiple | 1 2 2 2 1 1 1 |
Clear Cell Focus | 1 1 1 |
Congestion | 1 |
Developmental Malformation | 2 |
Eosinophilic Focus | 2 |
Fatty Change | 2 1 3 2 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Inflammation | 2 |
Mixed Cell Focus | 2 X |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Acinar Cell, Atrophy | 2 1 1 2 1 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Ulcer | 2 |
Ulcer, Multiple | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Ulcer | |
Ulcer, Multiple | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 4| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 0| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 6| 3| 6| 2| 3| 3| 5| 5| 5| 5|
| 4| 5| 3| 6| 1| 3| 4| 4| 3| 5| 4| 3| 0| 3| 0| 6| 5| 4| 0| 4| 3| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | |
Degeneration | 2 |
Hemorrhage | 3 |
Hyperplasia | 2 2 1 |
Hypertrophy | |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 3 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Pars Distalis, Angiectasis | 2 4 3 3 2 |
Pars Distalis, Cyst | 2 1 2 2 1 3 2 |
Pars Distalis, Hyperplasia | 1 2 3 1 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2|
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + M + + + + + + + + +|
Ectasia | 3 1 1 2 1 2 3 2 3 1 2 3 2 2 2 3|
Hyperplasia | |
Inflammation | 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 2 |
Corpus Luteum, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | 4 |
Bilateral, Dilatation | 3 |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 4| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 0| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 6| 3| 6| 2| 3| 3| 5| 5| 5| 5|
| 4| 5| 3| 6| 1| 3| 4| 4| 3| 5| 4| 3| 0| 3| 0| 6| 5| 4| 0| 4| 3| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Cyst | 2 |
Lumbar, Hyperplasia, Lymphoid | 2 |
Lumbar, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + + + M + + + M + + + + M M + + + + +|
Hemorrhage | 1 2 3 2|
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 2 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 1 3 4 1 1 2 2 1 2 1 3 1 2|
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 2 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 3 2 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 1 2 1 2 1 1 2 1 3 1 2 2 2 1 4 1 2 2 1 2 2|
Pigmentation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lactation | 3 3 2 2 3 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tail, Hyperkeratosis | 3 |
Tail, Parakeratosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 3 1 2 3 |
Hemorrhage | 2 1 |
Hydrocephalus | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 4| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 0| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 6| 3| 6| 2| 3| 3| 5| 5| 5| 5|
| 4| 5| 3| 6| 1| 3| 4| 4| 3| 5| 4| 3| 0| 3| 0| 6| 5| 4| 0| 4| 3| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 2 2 |
Infiltration Cellular, Histiocyte | |
Inflammation | 1 3 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation | 2 2 1 2 |
Goblet Cell, Hyperplasia | 2 |
Nasolacrimal Duct, Inflammation | 1 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Infarct | |
Mineralization | 1 1 1 1 1 1|
Nephropathy, Chronic | 2 1 1 1 2 2 2 1 2 1 1 2 2 1 2 2 1 3 1 1 2 2 1 1 1|
Pigmentation | 3 1 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 56 |
Inflammation | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 54 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | 1 | 7 1.1|
Basophilic Focus, Multiple | | 22 1.7|
Clear Cell Focus | | 3 1.0|
Congestion | | 1 1.0|
Developmental Malformation | | 2 2.0|
Eosinophilic Focus | | 1 2.0|
Fatty Change | | 10 2.2|
Hematopoietic Cell Proliferation | 1 1 | 4 1.0|
Hemorrhage | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | | 3 |
Inflammation | 1 1 | 4 1.3|
Mixed Cell Focus | | 2 2.0|
Necrosis | | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Accessory Spleen | | 1 |
Acinar Cell, Atrophy | 1 1 | 19 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Hyperplasia | | 2 2.0|
Ulcer | | 3 2.0|
Ulcer, Multiple | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 56 |
Inflammation | | 1 2.0|
Ulcer | | 2 2.5|
Ulcer, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 1 1 1 1 1 1 | 38 1.1|
Atrium, Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Angiectasis | 2 | 4 1.5|
Cyst | | 1 3.0|
Degeneration | | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia | | 5 1.4|
Hypertrophy | | 1 1.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | | 8 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 55 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 56 |
Cyst | | 3 2.3|
Hyperplasia | | 1 3.0|
Pars Distalis, Angiectasis | 3 2 | 11 2.6|
Pars Distalis, Cyst | 1 2 | 16 1.9|
Pars Distalis, Hyperplasia | 3 2 | 9 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | | 8 1.9|
Follicle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 54 |
Ectasia | 2 3 2 2 | 32 2.2|
Hyperplasia | | 2 2.0|
Inflammation | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 56 |
Cyst | | 5 2.2|
Corpus Luteum, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 56 |
Dilatation | | 1 3.0|
Hemorrhage | | 1 4.0|
Bilateral, Dilatation | | 2 2.5|
Endometrium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Hyperplasia | | 7 2.6|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Lumbar, Cyst | | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 36 |
Hemorrhage | 2 2 1 1 1 2 | 12 1.8|
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 55 |
Hemorrhage | | 2 1.5|
Hyperplasia, Plasma Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 56 |
Edema | | 1 3.0|
Hemorrhage | | 8 1.9|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 54 |
Hemorrhage | 1 2 2 2 2 1 | 37 1.9|
Infiltration Cellular, Histiocyte | | 1 3.0|
Pigmentation | | 22 1.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Hematopoietic Cell Proliferation | | 5 2.2|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 54 |
Atrophy | 2 2 2 1 | 44 2.1|
Pigmentation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Lactation | | 17 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Tail, Hyperkeratosis | | 1 3.0|
Tail, Parakeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Compression | | 13 2.2|
Hemorrhage | | 2 1.5|
Hydrocephalus | | 3 2.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Inflammation | | 3 1.7|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Hemorrhage | 1 2 1 1 | 10 1.4|
Infiltration Cellular, Histiocyte | | 1 1.0|
Inflammation | | 4 1.5|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + | 56 |
Foreign Body | | 2 1.5|
Inflammation | | 7 1.7|
Goblet Cell, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation | | 2 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 | 2 2.0|
Respiratory Epithelium, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Cyst | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infarct | | 1 3.0|
Mineralization | 1 1 1 1 1 1 | 14 1.0|
Nephropathy, Chronic | 1 1 1 1 1 | 52 1.6|
Pigmentation | | 3 1.7|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 56 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 6| 7| 7| 7| 1| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 2| 4| 3| 3| 3| 3| 7| 4| 3| 7| 3| 7| 3| 3| 3| 7| 2| 3| 3| 3|
| 3| 4| 3| 5| 9| 0| 8| 4| 4| 4| 5| 8| 5| 4| 7| 4| 2| 3| 3| 3| 6| 4| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A A + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 |
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 2 3 1 2 2 2 3 2|
Clear Cell Focus | 1 |
Eosinophilic Focus | 2 1 1 3 |
Fatty Change | 2 1 |
Hepatodiaphragmatic Nodule | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 1 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinar Cell, Atrophy | 2 1 4 1 1 2 1 2 2 3 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 1 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 2 |
Cytoplasmic Alteration | |
Degeneration | |
Hemorrhage | |
Hyperplasia | 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Islets, Pancreatic | + |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 6| 7| 7| 7| 1| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 2| 4| 3| 3| 3| 3| 7| 4| 3| 7| 3| 7| 3| 3| 3| 7| 2| 3| 3| 3|
| 3| 4| 3| 5| 9| 0| 8| 4| 4| 4| 5| 8| 5| 4| 7| 4| 2| 3| 3| 3| 6| 4| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + M +|
Pars Distalis, Angiectasis | 2 3 2 3 4 2 |
Pars Distalis, Cyst | 2 1 3 2 2 1 3 2 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2 3 2|
Pars Nervosa, Developmental | |
Malformation | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Ectasia | 2 3 2 2 2 2 3 2 2 2 3 2 2|
Hyperplasia | 2 3 |
Inflammation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 1 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + |
Axillary, Hyperplasia, Lymphoid | 3 |
Axillary, Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + M + M + + + + M + + + M + + + M + M +|
Hemorrhage | 1 1 2 1 3 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 6| 7| 7| 7| 1| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 2| 4| 3| 3| 3| 3| 7| 4| 3| 7| 3| 7| 3| 3| 3| 7| 2| 3| 3| 3|
| 3| 4| 3| 5| 9| 0| 8| 4| 4| 4| 5| 8| 5| 4| 7| 4| 2| 3| 3| 3| 6| 4| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | 2 2 1 2 2 2 3 2 3 2 2 2 2 2 1 1|
Pigmentation | 1 2 1 2 1 1 2 2 3 2 2 2 2 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + M + + + + +|
Atrophy | 2 2 2 2 1 2 2 1 1 1 2 2 2|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hemorrhage | 2 |
Lactation | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Ulcer, Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 3 3 3 3 |
Turbinate, Hyperostosis | 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 2 2 |
Hemorrhage | 1 3 1 2 1 1 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation | 3 1 |
Alveolar Epithelium, Hyperplasia | 2 2 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Foreign Body | |
Hemorrhage | |
Inflammation | 2 1 |
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 4 2 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 6| 7| 7| 7| 1| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 2| 4| 3| 3| 3| 3| 7| 4| 3| 7| 3| 7| 3| 3| 3| 7| 2| 3| 3| 3|
| 3| 4| 3| 5| 9| 0| 8| 4| 4| 4| 5| 8| 5| 4| 7| 4| 2| 3| 3| 3| 6| 4| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | 2 |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hypoplasia | 3 |
Mineralization | 1 1 1 1 |
Nephropathy, Chronic | 2 1 2 2 1 1 1 2 2 2 1 1 1 2 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5|
| 6| 3| 3| 4| 4| 5| 3| 5| 5| 4| 3| 3| 4| 9| 5| 4| 5| 4| 4| 3| 5| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1|
Basophilic Focus, Multiple | 1 2 2 1 2 1 1 3 2 1 1 2 2 1 1 |
Clear Cell Focus | |
Eosinophilic Focus | 1 1 2 3 |
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | 2 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinar Cell, Atrophy | 1 1 2 2 1 1 2 1 2 4 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cytoplasmic Alteration | 1 |
Degeneration | 2 |
Hemorrhage | 1 |
Hyperplasia | 2 2 |
Hypertrophy | 1 |
Vacuolization Cytoplasmic | 2 3 2 3 3 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5|
| 6| 3| 3| 4| 4| 5| 3| 5| 5| 4| 3| 3| 4| 9| 5| 4| 5| 4| 4| 3| 5| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 1 2 2 |
Pars Distalis, Cyst | 3 2 3 2 3 2 2 2 1 2|
Pars Distalis, Hyperplasia | 3 1 2 2 2 2 2 3 2 3 2|
Pars Nervosa, Developmental | |
Malformation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Ectasia | 2 3 2 1 3 3 2 2 2 2 1 2 3 3 |
Hyperplasia | 2 3 |
Inflammation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 2 2 |
Bilateral, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
Axillary, Hyperplasia, Lymphoid | |
Axillary, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M M + + + + + + + + + M M + + M + + + + + +|
Hemorrhage | 2 1 2 2 2 2 3 2 2 1 2 |
Pigmentation | 1 2 2 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5|
| 6| 3| 3| 4| 4| 5| 3| 5| 5| 4| 3| 3| 4| 9| 5| 4| 5| 4| 4| 3| 5| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 3 2 2 2 3 2 3 2 3 1 3 2 1 1 1 1 2|
Pigmentation | 2 2 3 1 1 1 2 3 1 1 1 2 1 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 1 2 1 2 2 |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Hemorrhage | |
Lactation | 2 3 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Ulcer, Multiple | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 2 4 |
Turbinate, Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 1 1 1 |
Infiltration Cellular, Histiocyte | |
Inflammation | 1 1 |
Alveolar Epithelium, Hyperplasia | 2 1 1 2 2 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Foreign Body | 2 |
Hemorrhage | 2 |
Inflammation | 2 2 1|
Goblet Cell, Hyperplasia | 1 2|
Nasolacrimal Duct, Inflammation | |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5|
| 6| 3| 3| 4| 4| 5| 3| 5| 5| 4| 3| 3| 4| 9| 5| 4| 5| 4| 4| 3| 5| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Hemorrhage | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hypoplasia | |
Mineralization | 1 1 1 1 2 1|
Nephropathy, Chronic | 2 1 2 1 1 1 2 1 1 2 2 2 1 1 2 1 3 2 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + M + + + + | 54 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 | 6 1.0|
Basophilic Focus, Multiple | 1 1 | 34 1.8|
Clear Cell Focus | | 1 1.0|
Eosinophilic Focus | | 8 1.8|
Fatty Change | 2 | 4 1.8|
Hepatodiaphragmatic Nodule | | 3 2.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation | | 3 1.3|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 55 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Acinar Cell, Atrophy | 2 1 1 | 28 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 55 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 55 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 54 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 55 |
Cardiomyopathy | 1 1 1 1 1 1 | 30 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 55 |
Angiectasis | | 7 1.7|
Cytoplasmic Alteration | | 1 1.0|
Degeneration | 1 | 2 1.5|
Hemorrhage | | 1 1.0|
Hyperplasia | 1 | 5 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | | 1 1.0|
Vacuolization Cytoplasmic | | 13 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 55 |
Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 53 |
Pars Distalis, Angiectasis | 2 3 | 12 2.3|
Pars Distalis, Cyst | 3 1 | 21 2.1|
Pars Distalis, Hyperplasia | 2 3 3 1 | 24 2.2|
Pars Nervosa, Developmental | | |
Malformation | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 55 |
C-Cell, Hyperplasia | | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 54 |
Abscess | | 1 3.0|
Ectasia | 2 2 2 2 2 3 | 33 2.2|
Hyperplasia | | 4 2.5|
Inflammation | 1 | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 55 |
Cyst | 2 2 | 9 2.1|
Bilateral, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 55 |
Cyst | | 1 2.0|
Dilatation | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 55 |
Hyperplasia | | 7 2.4|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Axillary, Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 40 |
Hemorrhage | 1 2 1 2 2 1 | 23 1.7|
Pigmentation | | 7 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 55 |
Cyst | | 1 2.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
Hemorrhage | 1 | 8 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 54 |
Hemorrhage | 2 2 2 2 2 1 | 41 1.9|
Pigmentation | | 31 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 55 |
Hematopoietic Cell Proliferation | | 11 1.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 53 |
Atrophy | 2 1 1 1 | 26 1.5|
Hemorrhage | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 55 |
Abscess | | 1 2.0|
Hemorrhage | | 1 2.0|
Lactation | | 7 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + | 55 |
Ulcer | 2 | 1 2.0|
Ulcer, Multiple | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 55 |
Femur, Hyperostosis | | 6 3.0|
Turbinate, Hyperostosis | | 3 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 55 |
Compression | | 8 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
37.5 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 55 |
Congestion | | 4 2.5|
Hemorrhage | 1 2 1 | 15 1.3|
Infiltration Cellular, Histiocyte | | 1 1.0|
Inflammation | | 4 1.5|
Alveolar Epithelium, Hyperplasia | | 12 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + | 55 |
Angiectasis | | 1 2.0|
Foreign Body | | 1 2.0|
Hemorrhage | | 1 2.0|
Inflammation | | 5 1.6|
Goblet Cell, Hyperplasia | 1 1 | 4 1.3|
Nasolacrimal Duct, Inflammation | | 2 3.0|
Respiratory Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 55 |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Hemorrhage | | 1 2.0|
Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 55 |
Congestion | | 1 2.0|
Hypoplasia | | 1 3.0|
Mineralization | 1 1 1 1 2 1 | 16 1.1|
Nephropathy, Chronic | 1 1 1 1 1 | 44 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 54 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 3| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 1| 2| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 7| 3| 3| 3| 0|
| 5| 3| 3| 6| 6| 4| 4| 4| 5| 4| 4| 0| 4| 5| 3| 4| 7| 5| 3| 4| 7| 3| 3| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
75 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A A + + + + + + A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | 1 2 1 1 1 1 |
Basophilic Focus, Multiple | 2 3 2 2 1 1 2 1 2 1 1 2 1 1|
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Congestion | 2 2 2 |
Eosinophilic Focus | 3 |
Eosinophilic Focus, Multiple | 3 2 3 |
Fatty Change | 2 1 1 2 3 |
Hepatodiaphragmatic Nodule | X 2 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | 2 2 1 1 |
Mixed Cell Focus | 1 2 |
Necrosis | 2 |
Pigmentation | |
Vacuolization Cytoplasmic | 3 3 3 3 |
Centrilobular, Cytoplasmic Alteration| 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Acinar Cell, Atrophy | 1 2 1 1 3 1 1 2 1 3 2 |
__________________________________________________________________________|
Pharynx | + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 3 |
Ulcer | 2 |
Ulcer, Multiple | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 2 2 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 3| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 1| 2| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 7| 3| 3| 3| 0|
| 5| 3| 3| 6| 6| 4| 4| 4| 5| 4| 4| 0| 4| 5| 3| 4| 7| 5| 3| 4| 7| 3| 3| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
75 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 2 |
Congestion | 2 |
Degeneration | 2 |
Hemorrhage | |
Hypertrophy | |
Vacuolization Cytoplasmic | 2 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + M + + + + + + + M + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Pars Distalis, Angiectasis | 3 4 3 2 |
Pars Distalis, Cyst | 1 2 3 1 2 2 |
Pars Distalis, Hyperplasia | 1 2 2 3 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 |
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + M + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Ectasia | 2 3 2 2 2 3 3 2 2 2 2 3 2 1 2 3|
Hyperplasia | 2 |
Inflammation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | 1 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 |
Prolapse | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 3 1 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M + + + M + + + + + + M + M M M + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 3| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 1| 2| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 7| 3| 3| 3| 0|
| 5| 3| 3| 6| 6| 4| 4| 4| 5| 4| 4| 0| 4| 5| 3| 4| 7| 5| 3| 4| 7| 3| 3| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
75 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 3 1 2 3 1 2 |
Pigmentation | 1 1 1 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + M + + + + + M + + + + M +|
Hemorrhage | 3 2 1 2 1 1 2 2 2 2 1 3 2 1 |
Pigmentation | 2 2 2 2 1 2 1 1 2 2 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 1 |
Pigmentation | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Atrophy | 1 1 1 1 2 3 1 2 1 1 2 3 2 2 2 4 3|
Congestion | 3 |
Hemorrhage | 1 3 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lactation | 3 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 3 2 |
Turbinate, Hyperostosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 3 2 2 2 2 2 |
Hemorrhage | 3 2 1 |
Hydrocephalus | 3 |
Necrosis | 2 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | 2 1 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 3| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 1| 2| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 7| 3| 3| 3| 0|
| 5| 3| 3| 6| 6| 4| 4| 4| 5| 4| 4| 0| 4| 5| 3| 4| 7| 5| 3| 4| 7| 3| 3| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
75 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 2 1 1 2|
Infiltration Cellular, Histiocyte | 1 |
Inflammation | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 2 2 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation | 2 |
Goblet Cell, Hyperplasia | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Bilateral, Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 2 |
Mineralization | 1 1 1 1 1 |
Necrosis | 1 |
Nephropathy, Chronic | 2 1 1 2 2 2 3 2 1 1 1 1 1 2 1 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 5| 5| 5|
| 3| 4| 6| 3| 4| 5| 5| 5| 0| 0| 5| 5| 4| 4| 4| 3| 6| 3| 3| 4| 4| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 1 1 |
Basophilic Focus, Multiple | 2 1 1 2 3 1 1 1 2 2 2 1 2 2 1 1 |
Clear Cell Focus | 1 1 |
Clear Cell Focus, Multiple | 1 |
Congestion | |
Eosinophilic Focus | 2 2 1 |
Eosinophilic Focus, Multiple | |
Fatty Change | 1 1 2 1 |
Hepatodiaphragmatic Nodule | 2 X |
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 1 |
Mixed Cell Focus | |
Necrosis | |
Pigmentation | 1|
Vacuolization Cytoplasmic | |
Centrilobular, Cytoplasmic Alteration| |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Acinar Cell, Atrophy | 1 1 3 1 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | |
Ulcer | 3 |
Ulcer, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 1 1 1 1 2 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 5| 5| 5|
| 3| 4| 6| 3| 4| 5| 5| 5| 0| 0| 5| 5| 4| 4| 4| 3| 6| 3| 3| 4| 4| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 3 2 2 2 |
Congestion | |
Degeneration | |
Hemorrhage | 1 |
Hypertrophy | 2 |
Vacuolization Cytoplasmic | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + M + + + + M + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 2 2 3 2 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Ectasia | 3 2 3 2 2 1 2 2 1 2 2 2 2 1 2 2 2|
Hyperplasia | |
Inflammation | 3 2 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | |
Bilateral, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 3 3 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + M + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 5| 5| 5|
| 3| 4| 6| 3| 4| 5| 5| 5| 0| 0| 5| 5| 4| 4| 4| 3| 6| 3| 3| 4| 4| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 1 2 1 1 2 4 1 1 1 2|
Pigmentation | 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + M + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 3 1 1 2 2 1 2 2 2 2 2 2 1 1 3 1 2 1 2|
Pigmentation | 2 1 2 1 2 2 2 1 2 2 2 2 2 2 2 2 1 3 |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2|
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 3 1 3 3 2 2 1 1 3 2 1 1|
Congestion | |
Hemorrhage | 1 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lactation | 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
Turbinate, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 3 2 2 1 2 |
Hemorrhage | 1 3 |
Hydrocephalus | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation | 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 5| 5| 5|
| 3| 4| 6| 3| 4| 5| 5| 5| 0| 0| 5| 5| 4| 4| 4| 3| 6| 3| 3| 4| 4| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 1 1 2 1 1 |
Infiltration Cellular, Histiocyte | |
Inflammation | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Inflammation | 1 2 2 |
Goblet Cell, Hyperplasia | 1 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Bilateral, Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Mineralization | 1 1 1 1 |
Necrosis | |
Nephropathy, Chronic | 1 2 1 2 2 1 1 2 2 2 1 2 1 1 1 1 1 1 2 1 1 1|
Pigmentation | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
75 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Angiectasis | | 2 2.0|
Basophilic Focus | 1 1 1 1 1 1 | 15 1.1|
Basophilic Focus, Multiple | | 30 1.6|
Clear Cell Focus | | 2 1.0|
Clear Cell Focus, Multiple | | 1 1.0|
Congestion | | 3 2.0|
Eosinophilic Focus | 2 | 5 2.0|
Eosinophilic Focus, Multiple | | 3 2.7|
Fatty Change | | 9 1.6|
Hepatodiaphragmatic Nodule | | 5 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | | 6 1.3|
Mixed Cell Focus | | 2 1.5|
Necrosis | | 1 2.0|
Pigmentation | | 1 1.0|
Vacuolization Cytoplasmic | | 4 3.0|
Centrilobular, Cytoplasmic Alteration| | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Accessory Spleen | | 1 |
Acinar Cell, Atrophy | 2 2 1 | 26 1.5|
__________________________________________________________________________|____________|
Pharynx | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Hyperplasia | 2 | 3 2.3|
Inflammation | | 1 3.0|
Ulcer | | 2 2.5|
Ulcer, Multiple | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 55 |
Inflammation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
75 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 1 1 1 1 1 | 34 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Angiectasis | | 10 2.1|
Congestion | | 1 2.0|
Degeneration | | 1 2.0|
Hemorrhage | | 1 1.0|
Hypertrophy | | 1 2.0|
Vacuolization Cytoplasmic | | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 55 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 55 |
Cyst | | 1 2.0|
Pars Distalis, Angiectasis | | 5 3.0|
Pars Distalis, Cyst | 3 1 | 13 2.0|
Pars Distalis, Hyperplasia | 1 | 15 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | 2 | 5 1.4|
Follicle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 54 |
Abscess | | 1 3.0|
Ectasia | 3 3 1 2 3 | 38 2.1|
Hyperplasia | | 1 2.0|
Inflammation | | 5 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 56 |
Cyst | | 2 2.0|
Hemorrhage | | 1 1.0|
Bilateral, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
75 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 56 |
Dilatation | 2 | 5 2.0|
Prolapse | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Atrophy | | 2 2.5|
Hyperplasia | | 6 2.5|
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 46 |
Hemorrhage | 1 1 2 2 1 1 | 22 1.6|
Pigmentation | | 9 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 53 |
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 56 |
Hemorrhage | | 8 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 51 |
Hemorrhage | 3 2 2 2 1 1 | 41 1.8|
Pigmentation | | 31 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 54 |
Hematopoietic Cell Proliferation | | 7 1.7|
Pigmentation | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 55 |
Atrophy | 1 2 | 34 1.8|
Congestion | | 1 3.0|
Hemorrhage | | 4 1.5|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
Lactation | | 9 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
Femur, Hyperostosis | | 2 2.5|
Turbinate, Hyperostosis | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
75 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Compression | | 15 2.1|
Hemorrhage | | 5 2.0|
Hydrocephalus | | 1 3.0|
Necrosis | | 3 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Hemorrhage | | 1 2.0|
Inflammation | | 4 1.8|
Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Congestion | | 6 2.0|
Hemorrhage | 3 | 10 1.5|
Infiltration Cellular, Histiocyte | | 1 1.0|
Inflammation | | 3 1.7|
Alveolar Epithelium, Hyperplasia | 1 | 12 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + | 55 |
Angiectasis | | 3 2.0|
Inflammation | | 4 1.8|
Goblet Cell, Hyperplasia | 1 | 2 1.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Bilateral, Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Angiectasis | | 1 2.0|
Congestion | | 1 2.0|
Mineralization | 1 1 1 1 2 1 | 15 1.1|
Necrosis | | 1 1.0|
Nephropathy, Chronic | 1 1 1 1 1 1 | 43 1.4|
Pigmentation | | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
75 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 55 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 1| 4| 5| 3| 4| 5| 3| 3| 3| 4| 8| 4| 5| 5| 4| 3| 3| 4| 5| 4| 4| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Abscess | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 1 1 |
Basophilic Focus, Multiple | 1 1 2 3 1 2 3 2 2 1 2 3 2 2 2 2 2 2|
Clear Cell Focus | 1 |
Clear Cell Focus, Multiple | 1 |
Congestion | 1 2 |
Developmental Malformation | 2 |
Eosinophilic Focus | 2 2 |
Eosinophilic Focus, Multiple | |
Fatty Change | 2 1|
Hemorrhage | |
Hepatodiaphragmatic Nodule | 2 2 X 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 2 |
Necrosis | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Mesentery | +|
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | |
Acinar Cell, Atrophy | 1 3 1 2 1 2 2 2 2 1 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 1 2 2 1 2 2 2 2 2 1 2 1 2 2|
Atrium, Thrombosis | 3 |
Endocardium, Proliferation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 1| 4| 5| 3| 4| 5| 3| 3| 3| 4| 8| 4| 5| 5| 4| 3| 3| 4| 5| 4| 4| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 3 |
Congestion | 3 |
Degeneration | 3 |
Hemorrhage | 3 1 2 |
Hyperplasia | 2 1 |
Hypertrophy | |
Infiltration Cellular, Lymphocyte | |
Vacuolization Cytoplasmic | 2 3 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + M + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Pars Distalis, Angiectasis | 2 2 4 3 |
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 3 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 3 3 3 2 3 2 3 2 2 2 3 2 3 3 |
Hyperplasia | 3 2 2 3 |
Inflammation | 1 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 4 |
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 1| 4| 5| 3| 4| 5| 3| 3| 3| 4| 8| 4| 5| 5| 4| 3| 3| 4| 5| 4| 4| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + M + + + + M M M + M + + + + + M M M M|
Hemorrhage | 1 1 2 2 2 2 2 2 |
Pigmentation | 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + M + + + + + M + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + M + + + + + + + + + +|
Hemorrhage | 1 2 1 1 2 1 3 2 1 1 3 2 1 3 2 |
Pigmentation | 1 1 1 1 1 2 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Developmental Malformation | 2 |
Hematopoietic Cell Proliferation | 1 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 1 3 2 2 1 1 2 2 2 2 2 |
Congestion | |
Cyst | 3 |
Hemorrhage | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3|
Hyperplasia | |
Inflammation | 3 |
Lactation | 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
Turbinate, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 2 2 2 2 2|
Cyst | 2 |
Hemorrhage | 2 2|
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3|
| 1| 4| 5| 3| 4| 5| 3| 3| 3| 4| 8| 4| 5| 5| 4| 3| 3| 4| 5| 4| 4| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Infiltration Cellular, Lymphocyte | 3 2 |
Inflammation | 2 2 |
Metaplasia, Squamous | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation | 2 2 |
Alveolar Epithelium, Hyperplasia | 1 2 2 1 2 2 2 2 2 3 1 2 3 3 2 3 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Foreign Body | |
Hemorrhage | |
Inflammation | 2 2 3 |
Goblet Cell, Hyperplasia | 1 |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 2|
Respiratory Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Mineralization | 1 1 1 1 1 |
Nephropathy, Chronic | 1 1 1 2 1 1 1 1 3 1 2 1 1 2 1 1 1 2|
Pigmentation | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + M +|
Arteriole, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 9| 3| 0| 3| 3| 5| 5| 5| 5|
| 3| 0| 4| 4| 3| 3| 5| 5| 3| 7| 0| 4| 3| 3| 2| 3| 6| 4| 5| 3| 3| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
Abscess | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + A + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + A + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Basophilic Focus, Multiple | 2 2 2 2 1 1 2 2 2 2 2 2 2 1 1 1 1 2 1 1|
Clear Cell Focus | 1 |
Clear Cell Focus, Multiple | |
Congestion | 1 2 |
Developmental Malformation | 1 |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | 2 |
Fatty Change | 3 2 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation | |
Necrosis | 1 3 |
Pigmentation | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | 1 |
Acinar Cell, Atrophy | 1 1 2 1 2 2 2 1 2 2 2 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 2 1 1 2 2 1 1 1 1 1 1|
Atrium, Thrombosis | 2 |
Endocardium, Proliferation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 9| 3| 0| 3| 3| 5| 5| 5| 5|
| 3| 0| 4| 4| 3| 3| 5| 5| 3| 7| 0| 4| 3| 3| 2| 3| 6| 4| 5| 3| 3| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 3 |
Congestion | |
Degeneration | |
Hemorrhage | 2 |
Hyperplasia | 1 |
Hypertrophy | 1 |
Infiltration Cellular, Lymphocyte | 1 |
Vacuolization Cytoplasmic | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Congestion | |
Pars Distalis, Angiectasis | 3 4 3 |
Pars Distalis, Cyst | 2 2 2 2 2 2 2 |
Pars Distalis, Hyperplasia | 2 1 2 2 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 1 3 2 3 2 2 2 2 3 2 2 3 2 2 |
Hyperplasia | 2 2 |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 |
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Myelofibrosis | 3 1 |
__________________________________________________________________________|
Lymph Node | + |
Axillary, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 9| 3| 0| 3| 3| 5| 5| 5| 5|
| 3| 0| 4| 4| 3| 3| 5| 5| 3| 7| 0| 4| 3| 3| 2| 3| 6| 4| 5| 3| 3| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + M + + M + + + M + + + + M M M + + + +|
Hemorrhage | 1 2 1 2 1 2 |
Pigmentation | 1 1 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hemorrhage | 1 2 2 3 2 2 2 2 2 2 1 2 1 2 |
Pigmentation | 2 2 2 2 1 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Developmental Malformation | |
Hematopoietic Cell Proliferation | 2 2 1 |
Pigmentation | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 4 2 2 2 3 2 2 |
Congestion | 3 |
Cyst | |
Hemorrhage | 1 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 2 |
Inflammation | 2 |
Lactation | 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 4 3 2 2 |
Turbinate, Hyperostosis | 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 3 |
Cyst | |
Hemorrhage | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 9| 3| 0| 3| 3| 5| 5| 5| 5|
| 3| 0| 4| 4| 3| 3| 5| 5| 3| 7| 0| 4| 3| 3| 2| 3| 6| 4| 5| 3| 3| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 3 1 2 1 |
Metaplasia, Squamous | 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 1 2 1 1 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Foreign Body | 2 |
Hemorrhage | 2 |
Inflammation | 1 1 2 |
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 1 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 2 2 1 1|
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Mineralization | 1 1 2 1 1 1 1|
Nephropathy, Chronic | 2 1 1 1 1 1 1 1 1 2 1 2 1 1 2 2 1 1 1 1 1|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + M + + +|
Arteriole, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
150 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 54 |
Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | 1 1 1 | 7 1.1|
Basophilic Focus, Multiple | 1 2 | 40 1.8|
Clear Cell Focus | | 2 1.0|
Clear Cell Focus, Multiple | | 1 1.0|
Congestion | | 4 1.5|
Developmental Malformation | | 2 1.5|
Eosinophilic Focus | | 2 2.0|
Eosinophilic Focus, Multiple | | 1 2.0|
Fatty Change | | 4 2.0|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 6 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation | | 2 1.5|
Necrosis | | 3 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Ectopic Liver | 1 | 2 1.0|
Acinar Cell, Atrophy | 2 1 | 25 1.6|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Hyperplasia | | 1 2.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 56 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
150 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 1 1 1 1 1 | 41 1.4|
Atrium, Thrombosis | | 2 2.5|
Endocardium, Proliferation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Angiectasis | | 10 2.2|
Congestion | | 1 3.0|
Degeneration | | 1 3.0|
Hemorrhage | | 4 2.0|
Hyperplasia | | 3 1.3|
Hypertrophy | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Vacuolization Cytoplasmic | | 10 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 56 |
Hyperplasia | | 5 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 56 |
Angiectasis | | 1 4.0|
Congestion | | 1 2.0|
Pars Distalis, Angiectasis | | 7 3.0|
Pars Distalis, Cyst | | 9 2.0|
Pars Distalis, Hyperplasia | 2 1 1 | 21 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 56 |
Ectasia | 2 3 3 2 2 | 37 2.4|
Hyperplasia | | 6 2.3|
Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 56 |
Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
150 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | | 1 2.0|
Cyst | | 2 3.0|
Dilatation | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Hyperplasia | 1 | 6 2.0|
Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Axillary, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 38 |
Hemorrhage | 2 2 3 3 1 2 | 20 1.8|
Pigmentation | | 7 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 53 |
Hemorrhage | | 1 1.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
Hemorrhage | 1 | 8 1.9|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 53 |
Hemorrhage | 2 2 2 2 1 1 | 35 1.8|
Pigmentation | | 17 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Congestion | | 1 2.0|
Developmental Malformation | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 1 | 10 1.5|
Pigmentation | | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 54 |
Atrophy | 2 1 1 | 24 1.9|
Congestion | | 1 3.0|
Cyst | | 1 3.0|
Hemorrhage | 1 1 1 | 7 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
Galactocele | | 1 3.0|
Hyperplasia | | 1 2.0|
Inflammation | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
150 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Lactation | | 8 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
Femur, Hyperostosis | 2 | 5 2.6|
Turbinate, Hyperostosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Compression | | 10 2.2|
Cyst | | 1 2.0|
Hemorrhage | | 2 2.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Foreign Body | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 3 2.3|
Inflammation | | 6 1.8|
Metaplasia, Squamous | | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Congestion | | 2 3.0|
Hemorrhage | 3 1 1 1 1 | 9 1.2|
Infiltration Cellular, Histiocyte | | 2 1.0|
Inflammation | | 3 2.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 35 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + | 56 |
Angiectasis | | 1 2.0|
Foreign Body | | 1 2.0|
Hemorrhage | | 1 2.0|
Inflammation | 1 | 7 1.7|
Goblet Cell, Hyperplasia | 1 1 | 3 1.0|
Nasolacrimal Duct, Inflammation | | 2 1.5|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 1 | 9 1.7|
Respiratory Epithelium, Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
150 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Congestion | | 1 2.0|
Mineralization | 2 1 1 1 1 | 17 1.1|
Nephropathy, Chronic | 1 1 1 1 1 | 44 1.3|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 52 |
Arteriole, Inflammation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 6| 5| 4| 7| 7| 4| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 4| 6| 3| 9| 2| 2| 3| 4| 3| 9| 3| 2| 2| 3| 8| 2| 9| 3| 3| 3| 2| 3| 6| 4| 8|
| 1| 6| 9| 2| 9| 9| 0| 0| 3| 8| 0| 9| 7| 0| 3| 9| 5| 0| 1| 2| 6| 0| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1 |
Basophilic Focus, Multiple | 1 |
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Congestion | 2 |
Cytoplasmic Alteration | 3 |
Degeneration, Cystic | 2 2 1|
Developmental Malformation | |
Eosinophilic Focus | 3 2 |
Eosinophilic Focus, Multiple | 2 |
Fatty Change | |
Hemorrhage | 1 |
Hepatodiaphragmatic Nodule | 3 |
Inflammation | |
Mixed Cell Focus | |
Mixed Cell Focus, Multiple | |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 2 2 3 1 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Acinar Cell, Atrophy | 3 2 2 1 2 2 2 2 2 3 2 1 2 2 1 2 2|
Acinar Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Inflammation | |
Ulcer | 3 2 2 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 3 2|
Ulcer | |
Ulcer, Multiple | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 6| 5| 4| 7| 7| 4| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 4| 6| 3| 9| 2| 2| 3| 4| 3| 9| 3| 2| 2| 3| 8| 2| 9| 3| 3| 3| 2| 3| 6| 4| 8|
| 1| 6| 9| 2| 9| 9| 0| 0| 3| 8| 0| 9| 7| 0| 3| 9| 5| 0| 1| 2| 6| 0| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 1 3 2 1 1 2 1 3|
Atrium, Dilatation | |
Atrium, Thrombosis | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cytoplasmic Alteration | 2|
Degeneration | 2 2 |
Hyperplasia | 1 2|
Hypertrophy | 2 |
Vacuolization Cytoplasmic | 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 1 1 3 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 3 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 2 1 |
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Granuloma Sperm | |
Hypospermia | 3 4 3 2 4 4 4 4 4 3 4 2 3 4 |
Inflammation, Chronic | 2 |
Inflammation | 2 |
Spermatocele | 4 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 6| 5| 4| 7| 7| 4| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 4| 6| 3| 9| 2| 2| 3| 4| 3| 9| 3| 2| 2| 3| 8| 2| 9| 3| 3| 3| 2| 3| 6| 4| 8|
| 1| 6| 9| 2| 9| 9| 0| 0| 3| 8| 0| 9| 7| 0| 3| 9| 5| 0| 1| 2| 6| 0| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Abscess | |
Ectasia | 3 1 2 3 2 3 3 2 2 2 3 1 3 3 2 2 3 2 3|
Inflammation | 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | 2|
Concretion | 2 |
Hyperplasia | 1 2 1 1 |
Inflammation | 3 3 3 2 2 3 1 2 1 2 3 2 2|
Epithelium, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 4 2 4 4 4 3 3 4 3 4 3 3 3 |
Inflammation | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 3 1 3 |
Arteriole, Inflammation | 2 |
Bilateral, Atrophy | 3 3 4 4 3 3 2|
Interstitial Cell, Hyperplasia | 2 2 1 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 2 3 4 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + M + + + + + + + M M + + + + + + + M|
Hemorrhage | 3 2 |
Hyperplasia, Plasma Cell | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 1 3 3 1 3 |
Hyperplasia, Plasma Cell | 2 1 3 |
Pigmentation | 2 3 2 2 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + M + M + + + M + + + + + + M + +|
Atrophy | 3 3 1 2 2 4 3 3 3 4 2 4|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 6| 5| 4| 7| 7| 4| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 4| 6| 3| 9| 2| 2| 3| 4| 3| 9| 3| 2| 2| 3| 8| 2| 9| 3| 3| 3| 2| 3| 6| 4| 8|
| 1| 6| 9| 2| 9| 9| 0| 0| 3| 8| 0| 9| 7| 0| 3| 9| 5| 0| 1| 2| 6| 0| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + M + + + + + + M|
Galactocele | |
Hyperplasia | 2 |
Inflammation | 2 |
Lactation | 1 2 3 2 3 2 2 3 2 |
Pigmentation | 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 1 3 2 3 |
Hemorrhage | 1 |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3|
Hemorrhage | 1 |
Inflammation | 2 1|
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchus, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 |
Foreign Body | 3 2 2 1 |
Hemorrhage | 2 2 2 |
Inflammation | 2 1 2 2 3 1 |
Polyp Inflammatory | |
Respiratory Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 6| 5| 4| 7| 7| 4| 7| 5| 7| 6| 7| 6| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 4| 6| 3| 9| 2| 2| 3| 4| 3| 9| 3| 2| 2| 3| 8| 2| 9| 3| 3| 3| 2| 3| 6| 4| 8|
| 1| 6| 9| 2| 9| 9| 0| 0| 3| 8| 0| 9| 7| 0| 3| 9| 5| 0| 1| 2| 6| 0| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | 3|
Hydronephrosis | |
Nephropathy, Chronic | 2 2 2 2 2 2 3 2 2 2 2 2 1 2 2 2 3 2 3 2 2 4|
Pigmentation | 3 2 |
Pelvis, Hyperplasia | |
Renal Tubule, Cytoplasmic Alteration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Dilatation | 3 3 3 |
Inflammation | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 6| 6| 7| 4| 6| 6| 7| 5| 6| 6| 5| 7| 6| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 9| 3| 6| 8| 3| 5| 1| 2| 1| 1| 6| 3| 2| 6| 2| 6| 2| 3| 3| 3| 5| 5| 5| 5|
| 0| 5| 0| 5| 1| 0| 4| 1| 9| 5| 7| 6| 0| 5| 6| 4| 3| 9| 9| 0| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + A + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1|
Basophilic Focus, Multiple | 2 2 1 1 |
Clear Cell Focus | |
Clear Cell Focus, Multiple | 2 1 |
Congestion | 3 2 |
Cytoplasmic Alteration | |
Degeneration, Cystic | 2 |
Developmental Malformation | 2 |
Eosinophilic Focus | 2 2 1 |
Eosinophilic Focus, Multiple | |
Fatty Change | 2 2 1 1 1 |
Hemorrhage | 1|
Hepatodiaphragmatic Nodule | |
Inflammation | 1 |
Mixed Cell Focus | 2 |
Mixed Cell Focus, Multiple | 2 3 |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinar Cell, Atrophy | 3 2 3 2 2 2 3 2 2 2 2 1 2|
Acinar Cell, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
Inflammation | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Ulcer | 3 |
Ulcer, Multiple | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 6| 6| 7| 4| 6| 6| 7| 5| 6| 6| 5| 7| 6| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 9| 3| 6| 8| 3| 5| 1| 2| 1| 1| 6| 3| 2| 6| 2| 6| 2| 3| 3| 3| 5| 5| 5| 5|
| 0| 5| 0| 5| 1| 0| 4| 1| 9| 5| 7| 6| 0| 5| 6| 4| 3| 9| 9| 0| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 1 1 2 1 3 2 2 2 2 1 2 1|
Atrium, Dilatation | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cytoplasmic Alteration | |
Degeneration | 2 |
Hyperplasia | 1 1 2 2 1 |
Hypertrophy | |
Vacuolization Cytoplasmic | 2 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + A + + + + + + + + + + + + + + + + + + + M + + +|
Angiectasis | 2|
Hyperplasia | 1 2 2 1 3 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + M M + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hyperplasia | 1 3 1 2 2|
Pars Intermedia, Angiectasis | 2|
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1|
Follicle, Dilatation | 2 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Granuloma Sperm | 3 |
Hypospermia | 4 4 4 3 2 4 |
Inflammation, Chronic | |
Inflammation | 3 |
Spermatocele | 3 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 6| 6| 7| 4| 6| 6| 7| 5| 6| 6| 5| 7| 6| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 9| 3| 6| 8| 3| 5| 1| 2| 1| 1| 6| 3| 2| 6| 2| 6| 2| 3| 3| 3| 5| 5| 5| 5|
| 0| 5| 0| 5| 1| 0| 4| 1| 9| 5| 7| 6| 0| 5| 6| 4| 3| 9| 9| 0| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Abscess | 4 |
Ectasia | 3 2 2 2 3 3 3 2 2 3 2 2 3 3 2 3 2 1|
Inflammation | 2 1 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | |
Concretion | 1 1 2 |
Hyperplasia | 1 |
Inflammation | 2 2 3 2 4 2 2 2 2 2 1 2 3 2|
Epithelium, Cytoplasmic Alteration | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + A + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 4 3 3 4 3 3 3 |
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 3 |
Arteriole, Inflammation | |
Bilateral, Atrophy | 4 4 3 |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 3 2 1|
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + M + + + + + + M + + + + + + M + + + + +|
Hemorrhage | 2 1 2 1|
Hyperplasia, Plasma Cell | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1|
Hyperplasia, Plasma Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | 1 2 1 4 2 1 1 1 1 2 2|
Hyperplasia, Plasma Cell | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 3 3 3 3 3 1 3 2 3 2 2 2 2 2 3 |
Hemorrhage | 3 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 6| 6| 7| 4| 6| 6| 7| 5| 6| 6| 5| 7| 6| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 9| 3| 6| 8| 3| 5| 1| 2| 1| 1| 6| 3| 2| 6| 2| 6| 2| 3| 3| 3| 5| 5| 5| 5|
| 0| 5| 0| 5| 1| 0| 4| 1| 9| 5| 7| 6| 0| 5| 6| 4| 3| 9| 9| 0| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | |
Inflammation | |
Lactation | 3 3 3 2 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 3 |
Hemorrhage | 1 |
Hydrocephalus | 3 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | 2 2|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hemorrhage | 2 3 2 1 1|
Inflammation | |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 1 1 2 2 |
Bronchus, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 3 |
Foreign Body | 1 |
Hemorrhage | 1 |
Inflammation | 1 2 |
Polyp Inflammatory | 1 |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 6| 6| 7| 4| 6| 6| 7| 5| 6| 6| 5| 7| 6| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 3| 9| 3| 6| 8| 3| 5| 1| 2| 1| 1| 6| 3| 2| 6| 2| 6| 2| 3| 3| 3| 5| 5| 5| 5|
| 0| 5| 0| 5| 1| 0| 4| 1| 9| 5| 7| 6| 0| 5| 6| 4| 3| 9| 9| 0| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Hydronephrosis | 2 |
Nephropathy, Chronic | 2 2 1 2 2 2 1 2 2 2 2 2 2 1 1 2 2 1 2 1 2|
Pigmentation | 2 |
Pelvis, Hyperplasia | 3 |
Renal Tubule, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Dilatation | 3 |
Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 53 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + | 55 |
Basophilic Focus | 1 | 9 1.0|
Basophilic Focus, Multiple | 1 | 6 1.3|
Clear Cell Focus | 1 1 1 | 3 1.0|
Clear Cell Focus, Multiple | | 2 1.5|
Congestion | | 3 2.3|
Cytoplasmic Alteration | | 1 3.0|
Degeneration, Cystic | | 4 1.8|
Developmental Malformation | | 1 2.0|
Eosinophilic Focus | | 5 2.0|
Eosinophilic Focus, Multiple | | 1 2.0|
Fatty Change | | 5 1.4|
Hemorrhage | | 2 1.0|
Hepatodiaphragmatic Nodule | | 1 3.0|
Inflammation | | 1 1.0|
Mixed Cell Focus | | 1 2.0|
Mixed Cell Focus, Multiple | | 2 2.5|
Necrosis | | 2 2.0|
Bile Duct, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis | | 6 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 55 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
Acinar Cell, Atrophy | 1 2 2 | 33 2.0|
Acinar Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 55 |
Hyperplasia | | 4 2.3|
Inflammation | | 1 2.0|
Ulcer | | 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | | 3 2.0|
Ulcer | | 1 3.0|
Ulcer, Multiple | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 2 1 1 1 1 1 | 42 1.7|
Atrium, Dilatation | | 1 2.0|
Atrium, Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 55 |
Congestion | | 1 2.0|
Cytoplasmic Alteration | | 1 2.0|
Degeneration | | 3 2.0|
Hyperplasia | | 7 1.4|
Hypertrophy | | 1 2.0|
Vacuolization Cytoplasmic | | 7 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 54 |
Angiectasis | | 1 2.0|
Hyperplasia | | 15 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 8 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 49 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 55 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 2 2.0|
Pars Distalis, Hyperplasia | 2 2 | 11 2.1|
Pars Intermedia, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 55 |
C-Cell, Hyperplasia | 1 | 8 1.8|
Follicle, Dilatation | 2 | 4 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 56 |
Atrophy | | 1 3.0|
Granuloma Sperm | | 1 3.0|
Hypospermia | | 20 3.5|
Inflammation, Chronic | | 1 2.0|
Inflammation | | 2 2.5|
Spermatocele | | 2 3.5|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 54 |
Abscess | | 1 4.0|
Ectasia | 1 3 3 3 3 2 | 43 2.4|
Inflammation | 1 1 1 | 11 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 56 |
Abscess | | 1 4.0|
Atrophy | | 1 2.0|
Concretion | 1 2 | 6 1.5|
Hyperplasia | | 5 1.2|
Inflammation | 1 2 2 2 2 | 32 2.2|
Epithelium, Cytoplasmic Alteration | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 55 |
Depletion Cellular | | 22 3.3|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 56 |
Atrophy | | 8 2.8|
Arteriole, Inflammation | | 1 2.0|
Bilateral, Atrophy | | 10 3.3|
Interstitial Cell, Hyperplasia | 2 2 | 16 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 55 |
Hyperplasia | 1 1 | 16 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Lumbar, Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 47 |
Hemorrhage | 2 2 1 1 | 10 1.7|
Hyperplasia, Plasma Cell | | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 2 2 | 6 2.0|
Hyperplasia, Plasma Cell | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
Hemorrhage | 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 55 |
Hemorrhage | 2 3 1 3 2 | 22 2.0|
Hyperplasia, Plasma Cell | | 3 2.0|
Pigmentation | | 5 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 51 |
Atrophy | 2 3 2 1 2 2 | 35 2.5|
Hemorrhage | | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 52 |
Galactocele | | 1 3.0|
Hyperplasia | | 1 2.0|
Inflammation | | 1 2.0|
Lactation | | 13 2.4|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
Cranium, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Compression | | 9 2.4|
Hemorrhage | | 2 1.0|
Hydrocephalus | | 4 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Foreign Body | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation | | 3 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Congestion | | 4 2.8|
Hemorrhage | 1 1 1 | 9 1.4|
Inflammation | 1 | 3 1.3|
Leukocytosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 5 1.4|
Bronchus, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 55 |
Angiectasis | | 7 2.4|
Foreign Body | 1 | 6 1.7|
Hemorrhage | 2 | 5 1.8|
Inflammation | 1 | 9 1.7|
Polyp Inflammatory | | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 55 |
Congestion | | 1 2.0|
Cyst | | 1 3.0|
Hydronephrosis | | 1 2.0|
Nephropathy, Chronic | 2 2 1 1 2 2 | 49 1.9|
Pigmentation | | 3 2.3|
Pelvis, Hyperplasia | | 1 3.0|
Renal Tubule, Cytoplasmic Alteration | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 56 |
Calculus Micro Observation Only | 3 | 1 3.0|
Dilatation | | 4 3.0|
Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 7| 7| 2| 5| 9| 3| 2| 4| 2| 2| 2| 3| 3| 3| 1| 4| 2| 3| 2| 3| 3| 9|
| 2| 0| 0| 6| 1| 9| 1| 5| 0| 9| 5| 9| 9| 9| 0| 0| 6| 8| 5| 9| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + A + A + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 1 1 1 1 |
Basophilic Focus, Multiple | 1 2 3 1 1 |
Clear Cell Focus | |
Clear Cell Focus, Multiple | 1 2 1 1 1 1 1 |
Congestion | |
Degeneration, Cystic | 1 1 3 2 1 1 1 |
Eosinophilic Focus | 2 1 1 1 2 |
Eosinophilic Focus, Multiple | 2 |
Fatty Change | 3 1 1 1 1 2 4 1 1|
Hemorrhage | |
Hepatodiaphragmatic Nodule | 2 |
Inflammation | 1 |
Mixed Cell Focus | 2 1 |
Necrosis | 1 2 |
Pigmentation | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Acinar Cell, Atrophy | 1 3 2 2 2 1 2 1 1 2 3 2 1 1 2|
Duct, Ectasia | 2 |
__________________________________________________________________________|
Pharynx | + |
Palate, Hyperplasia, Squamous | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 1 2 |
Ulcer | 3 |
Ulcer, Multiple | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
Necrosis | 2 |
Ulcer, Multiple | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 7| 7| 2| 5| 9| 3| 2| 4| 2| 2| 2| 3| 3| 3| 1| 4| 2| 3| 2| 3| 3| 9|
| 2| 0| 0| 6| 1| 9| 1| 5| 0| 9| 5| 9| 9| 9| 0| 0| 6| 8| 5| 9| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 1 2 2 2 2 2 1 2 2 2 2 3 2 2 2 2 2 2 3|
Inflammation | |
Atrium, Thrombosis | |
Valve, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Hyperplasia | 2 2 2|
Hypertrophy | 2 1 |
Vacuolization Cytoplasmic | 3 2 3 2 2 2 3 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 2 2 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + M M + + + + +|
Hyperplasia | 2 3 2 1 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 3 4 3 4 |
Pars Distalis, Cyst | 1 4 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 2 3 3 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3|
Hypospermia | 4 4 3 3 4 4 2 2 4 3 3 4 4 4 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 1 2 3 3 2 2 2 3 2 2 2 3 3 2 1 2 3|
Hyperplasia | |
Inflammation | 2 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1 |
Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 7| 7| 2| 5| 9| 3| 2| 4| 2| 2| 2| 3| 3| 3| 1| 4| 2| 3| 2| 3| 3| 9|
| 2| 0| 0| 6| 1| 9| 1| 5| 0| 9| 5| 9| 9| 9| 0| 0| 6| 8| 5| 9| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation | 3 2 2 2 2 2 2 2 4|
Epithelium, Cytoplasmic Alteration | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 3 3 2 4 2 4 2 3 3 4 3 |
Ectasia | 4|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Degeneration | 2 |
Hypospermia | |
Arteriole, Inflammation | 2 3 2 2 |
Bilateral, Atrophy | |
Bilateral, Degeneration | 2 |
Interstitial Cell, Hyperplasia | 2 2 1 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 4 2 2 3 2|
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + + M + + + + + M + + + + + M + + M M M|
Hemorrhage | 3 2 2 3 |
Inflammation | |
Pigmentation | 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 3 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 1 2 3 1 1 2 1 2 2 1 1 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation | 2 2 1 2 2 1 2 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 3 3 2 |
Capsule, Fibrosis | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 3 3 3 2 2 1 1 2 2 2 1 4 2 3 2 2 1 3|
Hemorrhage | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 7| 7| 2| 5| 9| 3| 2| 4| 2| 2| 2| 3| 3| 3| 1| 4| 2| 3| 2| 3| 3| 9|
| 2| 0| 0| 6| 1| 9| 1| 5| 0| 9| 5| 9| 9| 9| 0| 0| 6| 8| 5| 9| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | 3 |
Lactation | 3 3 2 3 2 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pinna, Parakeratosis | 3 |
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Hemorrhage | |
Coccygeal, Fracture | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 3 2 2 3 2 2 3 |
Hemorrhage | 1|
Hydrocephalus | 3 2 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | |
Inflammation | 1 3 1 1|
Leukocytosis | 3 |
Necrosis | |
Alveolar Epithelium, Hyperplasia | 2 1 2 3 2 |
Artery, Thrombosis | 2 |
Goblet Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Foreign Body | 1 |
Inflammation | 2 2 2 2 1 |
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 2 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 |
Respiratory Epithelium, Metaplasia, | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 7| 7| 2| 5| 9| 3| 2| 4| 2| 2| 2| 3| 3| 3| 1| 4| 2| 3| 2| 3| 3| 9|
| 2| 0| 0| 6| 1| 9| 1| 5| 0| 9| 5| 9| 9| 9| 0| 0| 6| 8| 5| 9| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation | |
Nephropathy, Chronic | 4 3 2 3 2 2 4 3 2 1 1 3 3 2 2 3 4 4 2 2 3 2 2|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation | 3|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 3| 6| 4| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 5| 4| 4| 4| 4|
DAY ON TEST | 0| 5| 0| 3| 8| 3| 5| 4| 3| 2| 2| 2| 5| 0| 7| 2| 3| 6| 2| 2| 6| 5| 5| 5| 5|
| 1| 5| 2| 0| 2| 0| 3| 6| 6| 9| 9| 0| 1| 0| 5| 9| 0| 3| 9| 9| 8| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + A + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + + + A A A + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 3 1 2 |
Basophilic Focus, Multiple | 1 1 1 2 1 |
Clear Cell Focus | 1 |
Clear Cell Focus, Multiple | 1 1 |
Congestion | 2 2 |
Degeneration, Cystic | 2 2 1 2 1|
Eosinophilic Focus | 1 2 |
Eosinophilic Focus, Multiple | 2 2 2 |
Fatty Change | 3 2 2 |
Hemorrhage | 1 1 |
Hepatodiaphragmatic Nodule | |
Inflammation | |
Mixed Cell Focus | 2 3 |
Necrosis | 1 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Mesentery | A + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Acinar Cell, Atrophy | 2 2 1 2 1 1 1 2 2 1 2 1 2|
Duct, Ectasia | |
__________________________________________________________________________|
Pharynx | |
Palate, Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation | 1 2 |
Ulcer | 3 2 |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 2 |
Necrosis | 2 2 |
Ulcer, Multiple | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 3| 6| 4| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 5| 4| 4| 4| 4|
DAY ON TEST | 0| 5| 0| 3| 8| 3| 5| 4| 3| 2| 2| 2| 5| 0| 7| 2| 3| 6| 2| 2| 6| 5| 5| 5| 5|
| 1| 5| 2| 0| 2| 0| 3| 6| 6| 9| 9| 0| 1| 0| 5| 9| 0| 3| 9| 9| 8| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 1 1 2 1 2 1 2 2 2 2 2 2 1 1 2 1 1 1 1 1|
Inflammation | 2 2 |
Atrium, Thrombosis | 3 |
Valve, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hyperplasia | |
Hypertrophy | 2 |
Vacuolization Cytoplasmic | 2 3 2 2 1 1 3 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Pars Distalis, Angiectasis | 3 4 1|
Pars Distalis, Cyst | 1 1 |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 1 2 2 2 2 2 3 2 2 2 1 2|
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Hypospermia | 4 4 2 4 3 4 4 4 4 4 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 3 2 2 2 3 4 3 3 2 3 2 2 3 2 3 2 2 2 3 2 2 2|
Hyperplasia | 2 |
Inflammation | 2 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1 1 2 1|
Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 3| 6| 4| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 5| 4| 4| 4| 4|
DAY ON TEST | 0| 5| 0| 3| 8| 3| 5| 4| 3| 2| 2| 2| 5| 0| 7| 2| 3| 6| 2| 2| 6| 5| 5| 5| 5|
| 1| 5| 2| 0| 2| 0| 3| 6| 6| 9| 9| 0| 1| 0| 5| 9| 0| 3| 9| 9| 8| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation | 3 2 2 2 3 2 1 3 2|
Epithelium, Cytoplasmic Alteration | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 4 3 3 1 4 4 2 3 3 3 3 |
Ectasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 3 |
Degeneration | |
Hypospermia | 2 |
Arteriole, Inflammation | 3 2 |
Bilateral, Atrophy | 3 4 |
Bilateral, Degeneration | |
Interstitial Cell, Hyperplasia | 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 2 3 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + M + M + + + + + + + + M M + + + + +|
Hemorrhage | 2 1 3 3 1 3 1 3 1 |
Inflammation | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 1 3 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 1 2 3 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | 1 3 1 2 1 1 3 2 2 3 2 3 2 1 2 1 2 1|
Hyperplasia, Plasma Cell | 2 |
Pigmentation | 1 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 2 1 4 2 2 1 2 3 2 1 1 3 1 3 2 1 2|
Hemorrhage | 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 3| 6| 4| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 5| 4| 4| 4| 4|
DAY ON TEST | 0| 5| 0| 3| 8| 3| 5| 4| 3| 2| 2| 2| 5| 0| 7| 2| 3| 6| 2| 2| 6| 5| 5| 5| 5|
| 1| 5| 2| 0| 2| 0| 3| 6| 6| 9| 9| 0| 1| 0| 5| 9| 0| 3| 9| 9| 8| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | 3 |
Lactation | 2 2 2 3 2 3 3 3 2 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pinna, Parakeratosis | |
Subcutaneous Tissue, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Hemorrhage | 2 |
Coccygeal, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 2 3 2 1 3 2 |
Hemorrhage | 3 |
Hydrocephalus | 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 3 |
Hemorrhage | 1 2 2 1 1 2 2|
Infiltration Cellular, Histiocyte | 2 |
Inflammation | 1 1 4 3 |
Leukocytosis | |
Necrosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 1 1 2|
Artery, Thrombosis | |
Goblet Cell, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + A + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 |
Foreign Body | 2 2 |
Inflammation | 2 2 3 2 2 |
Goblet Cell, Hyperplasia | 2 2|
Nasolacrimal Duct, Inflammation | 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 |
Respiratory Epithelium, Hyperplasia | 1|
Respiratory Epithelium, Metaplasia, | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 3| 6| 4| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 5| 4| 4| 4| 4|
DAY ON TEST | 0| 5| 0| 3| 8| 3| 5| 4| 3| 2| 2| 2| 5| 0| 7| 2| 3| 6| 2| 2| 6| 5| 5| 5| 5|
| 1| 5| 2| 0| 2| 0| 3| 6| 6| 9| 9| 0| 1| 0| 5| 9| 0| 3| 9| 9| 8| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation | 2 |
Nephropathy, Chronic | 4 1 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2 3 2 1 1 2 2|
Pigmentation | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | 1 1 | 11 1.5|
Basophilic Focus, Multiple | 1 | 11 1.4|
Clear Cell Focus | | 1 1.0|
Clear Cell Focus, Multiple | | 9 1.1|
Congestion | | 2 2.0|
Degeneration, Cystic | | 12 1.5|
Eosinophilic Focus | | 7 1.4|
Eosinophilic Focus, Multiple | | 4 2.0|
Fatty Change | | 12 1.8|
Hemorrhage | 1 | 3 1.0|
Hepatodiaphragmatic Nodule | X | 2 2.0|
Inflammation | | 1 1.0|
Mixed Cell Focus | | 4 2.0|
Necrosis | | 4 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Inflammation | | 1 2.0|
Acinar Cell, Atrophy | 2 2 1 2 | 32 1.7|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Hyperplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Hyperplasia | | 3 2.3|
Inflammation | | 4 1.5|
Ulcer | | 3 2.7|
Ulcer, Multiple | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Inflammation | | 1 2.0|
Necrosis | | 3 2.0|
Ulcer, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 1 1 1 1 1 2 | 53 1.7|
Inflammation | | 2 2.0|
Atrium, Thrombosis | | 1 3.0|
Valve, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Degeneration | | 1 2.0|
Hyperplasia | 1 | 4 1.8|
Hypertrophy | | 3 1.7|
Vacuolization Cytoplasmic | | 19 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 55 |
Hyperplasia | | 14 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 9 |
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 50 |
Hyperplasia | | 6 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 56 |
Hemorrhage | | 1 4.0|
Pars Distalis, Angiectasis | | 7 3.1|
Pars Distalis, Cyst | | 5 1.8|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 1 3 | 22 2.0|
Pars Intermedia, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 56 |
Granuloma Sperm | | 2 3.0|
Hypospermia | | 26 3.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 56 |
Ectasia | 2 2 1 2 3 2 | 49 2.3|
Hyperplasia | | 1 2.0|
Inflammation | 1 3 1 | 9 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 56 |
Concretion | 1 1 | 7 1.1|
Hyperplasia | | 4 1.8|
Inflammation | 2 2 1 1 2 1 | 24 2.1|
Epithelium, Cytoplasmic Alteration | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 56 |
Depletion Cellular | | 23 3.0|
Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 56 |
Atrophy | | 6 3.2|
Degeneration | | 1 2.0|
Hypospermia | | 1 2.0|
Arteriole, Inflammation | | 6 2.3|
Bilateral, Atrophy | | 2 3.5|
Bilateral, Degeneration | | 1 2.0|
Interstitial Cell, Hyperplasia | 2 | 12 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 55 |
Hyperplasia | | 15 2.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 43 |
Hemorrhage | 1 1 1 1 1 | 18 1.8|
Inflammation | | 1 2.0|
Pigmentation | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 55 |
Cyst | | 1 3.0|
Hemorrhage | | 4 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 7 2.3|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 56 |
Hemorrhage | 1 1 | 12 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 52 |
Hemorrhage | 1 3 2 2 1 | 36 1.8|
Hyperplasia, Plasma Cell | | 2 2.0|
Pigmentation | | 14 1.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 55 |
Congestion | | 2 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 6 2.3|
Capsule, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 56 |
Atrophy | 1 2 2 | 43 2.1|
Hemorrhage | | 8 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 53 |
Galactocele | | 2 3.0|
Lactation | | 18 2.4|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Pinna, Parakeratosis | | 1 3.0|
Subcutaneous Tissue, Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
Calvarium, Hemorrhage | | 1 2.0|
Coccygeal, Fracture | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Compression | | 17 2.3|
Hemorrhage | | 2 2.0|
Hydrocephalus | | 3 2.3|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Inflammation | | 2 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
37.5 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Congestion | | 5 2.4|
Hemorrhage | 1 1 1 | 15 1.3|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation | | 8 1.9|
Leukocytosis | | 1 3.0|
Necrosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 11 1.6|
Artery, Thrombosis | | 1 2.0|
Goblet Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 55 |
Angiectasis | | 4 2.3|
Foreign Body | | 3 1.7|
Inflammation | | 10 2.0|
Goblet Cell, Hyperplasia | 3 | 3 2.3|
Nasolacrimal Duct, Inflammation | | 3 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 | 3 1.7|
Respiratory Epithelium, Hyperplasia | | 3 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 55 |
Cyst | | 1 3.0|
Inflammation | | 1 2.0|
Nephropathy, Chronic | 2 1 1 2 2 2 | 52 2.3|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 55 |
Dilatation | | 1 3.0|
Inflammation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 3| 3| 4| 3|
| 6| 0| 0| 0| 9| 1| 0| 9| 0| 0| 0| 0| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Basophilic Focus, Multiple | 2 1 2 2 1 1 1 1 2 1 3 2 1 2|
Clear Cell Focus | 1 |
Clear Cell Focus, Multiple | 2 1 1 1 1 |
Degeneration, Cystic | 1 2 2 2 2 2 2 2 2 2|
Eosinophilic Focus | 2 1 2 1 2 |
Eosinophilic Focus, Multiple | 2 3 3 2 2 1 3|
Fatty Change | 2 1 4 |
Inflammation | 2 |
Mixed Cell Focus | 2 |
Mixed Cell Focus, Multiple | 2 2 |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | 2|
Infiltration Cellular, Lymphocyte | |
Acinar Cell, Atrophy | 1 2 2 1 2 2 1 2 1 3 2 3 2 2 2|
Artery, Inflammation | 4 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 |
Inflammation | 3 2 |
Ulcer | 2 2 |
Ulcer, Multiple | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer, Multiple | 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 3| 3| 4| 3|
| 6| 0| 0| 0| 9| 1| 0| 9| 0| 0| 0| 0| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 2 1 1 3 2 1 2 1 2 1 1 1 2 2 3 1 1 2 2 2 1 2|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration | |
Hyperplasia | 2 1 1 2 |
Hypertrophy | 3 2 |
Vacuolization Cytoplasmic | 2 2 2 2 2 1 2 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 3 1 2 2 1 1 2 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + M + + + + + + + M + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 2 |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 2 2 2 1 3 3 2 1 3 2 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Granuloma Sperm | 3|
Hypospermia | 4 4 2 4 4 2 4 4 4 4 2 3 2 3 4|
Inflammation | 2 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Ectasia | 3 2 3 3 2 1 2 2 1 3 2 3 1 2 3 2 2 3 2 2 |
Hyperplasia | 3 3 4 |
Inflammation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1 |
Congestion | |
Hyperplasia | 1 1 1 |
Inflammation | 1 2 2 2 1 2 2 3 2 3 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 3| 3| 4| 3|
| 6| 0| 0| 0| 9| 1| 0| 9| 0| 0| 0| 0| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Depletion Cellular | 2 4 3 3 2 4 4 4 2 2 3 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 3 3 3 |
Arteriole, Inflammation | 2 1 2 3 2 2|
Bilateral, Atrophy | 4|
Interstitial Cell, Hyperplasia | 1 1 2 1 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M + + + + M + + + M + + M M + M + + + + M +|
Hemorrhage | 3 1 1 1 3 1 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Hemorrhage | 3 2 |
Hyperplasia, Plasma Cell | 3 2|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + + + + + + + + + + + + M + + + + + +|
Hemorrhage | 2 2 2 2 1 1 1 2 2 2 3 1 |
Hyperplasia, Lymphoid | 3|
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 1 2 1 2 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Fibrosis | 2 1 |
Hematopoietic Cell Proliferation | 3 2 |
Hemorrhage | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 1 3 3 1 2 1 1 2 2 2 2 2 2 2 2 4 1|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lactation | 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 3| 3| 4| 3|
| 6| 0| 0| 0| 9| 1| 0| 9| 0| 0| 0| 0| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 |
Hemorrhage | |
Hydrocephalus | |
Necrosis | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 1 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Inflammation | 2 2 |
Alveolar Epithelium, Hyperplasia | 2 1 2 1 2 1 2 4 2 1 2 2 1 2|
Arteriole, Inflammation | 2 |
Artery, Inflammation | |
Artery, Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Foreign Body | 2 2 |
Hemorrhage | |
Inflammation | 2 2 |
Goblet Cell, Hyperplasia | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 |
Respiratory Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Hemorrhage | |
Inflammation | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 2 3 3 4 2 3 3 3 3 2 1 3 2 2 2 4 2 2 2 4 2 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 3| 2| 0| 5| 8| 3| 2| 1| 2| 3| 3| 3| 6| 1| 0| 2| 2| 3| 5| 5| 5| 5|
| 9| 9| 9| 0| 9| 0| 2| 4| 0| 9| 2| 9| 0| 0| 0| 7| 9| 3| 9| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A A + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1|
Basophilic Focus, Multiple | 1 2 2 1 1 1 1 1 2 2 |
Clear Cell Focus | 1 2 1 1 2 1|
Clear Cell Focus, Multiple | 1 1 1 |
Degeneration, Cystic | 1 1 2 2 1 |
Eosinophilic Focus | 2 2 2 |
Eosinophilic Focus, Multiple | 2 2 2 |
Fatty Change | 2 3 3 |
Inflammation | |
Mixed Cell Focus | 2 |
Mixed Cell Focus, Multiple | |
Necrosis | 1 |
Bile Duct, Hyperplasia | 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | |
Infiltration Cellular, Lymphocyte | 2 |
Acinar Cell, Atrophy | 1 2 1 1 2 2 2 1 1 2 1 1 3 1 2 1|
Artery, Inflammation | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | 4 |
Ulcer | |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Ulcer, Multiple | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 3| 2| 0| 5| 8| 3| 2| 1| 2| 3| 3| 3| 6| 1| 0| 2| 2| 3| 5| 5| 5| 5|
| 9| 9| 9| 0| 9| 0| 2| 4| 0| 9| 2| 9| 0| 0| 0| 7| 9| 3| 9| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 1 2 1 1 1 2 2 2 2 2 1 1 1 1 2 2 2 2 1 2 1 1 2 2|
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration | 2 |
Hyperplasia | 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 1 1 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + M + + + + M + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 2 2 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 3 2 3 1 3 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Granuloma Sperm | |
Hypospermia | 3 3 4 4 2 4 3 4 2 3 |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Ectasia | 1 2 2 3 2 2 1 2 2 2 1 2 2 3 2 3 2 2 2 3 2 1 2|
Hyperplasia | |
Inflammation | 2 2 2 2 1 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1 1 2|
Congestion | |
Hyperplasia | 1 1 2 |
Inflammation | 2 3 2 2 3 2 1 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 3| 2| 0| 5| 8| 3| 2| 1| 2| 3| 3| 3| 6| 1| 0| 2| 2| 3| 5| 5| 5| 5|
| 9| 9| 9| 0| 9| 0| 2| 4| 0| 9| 2| 9| 0| 0| 0| 7| 9| 3| 9| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Depletion Cellular | 3 2 2 4 3 2 3 4 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Arteriole, Inflammation | 1 3 2 2 |
Bilateral, Atrophy | 4 2 2 |
Interstitial Cell, Hyperplasia | 1 2 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 1 3 1 1 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + M M + + + M M M + M + + + + + + +|
Hemorrhage | 1 2 1 2 2 1 1|
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 1 2 1 1 |
Hyperplasia, Plasma Cell | 2 2 2 3 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | 2 2 2 2 2 3 1 2 2 2 1 2 1 1 2|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 1 1 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 1 1 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 3 1 1 3 4 1 2 3 2 1 4 3 2 2 1 1 2 1 2|
Hemorrhage | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lactation | 2 2 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 3| 2| 0| 5| 8| 3| 2| 1| 2| 3| 3| 3| 6| 1| 0| 2| 2| 3| 5| 5| 5| 5|
| 9| 9| 9| 0| 9| 0| 2| 4| 0| 9| 2| 9| 0| 0| 0| 7| 9| 3| 9| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 3 |
Hemorrhage | 2 |
Hydrocephalus | 2 |
Necrosis | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 |
Hemorrhage | 2 1|
Inflammation | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 3 2 2 2 1 1 2 1 2 1 2 3|
Arteriole, Inflammation | |
Artery, Inflammation | 2 |
Artery, Thrombosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Foreign Body | |
Hemorrhage | 3 2 |
Inflammation | 1 2 1 2 |
Goblet Cell, Hyperplasia | 2 1 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 |
Respiratory Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | 3 |
Inflammation | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 2 2 2 2 2 3 2 2 2 3 1 2 3 4 2 3 2 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
75 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 53 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | 1 1 | 6 1.0|
Basophilic Focus, Multiple | 1 1 | 26 1.5|
Clear Cell Focus | 1 | 8 1.3|
Clear Cell Focus, Multiple | | 8 1.1|
Degeneration, Cystic | | 15 1.7|
Eosinophilic Focus | | 8 1.8|
Eosinophilic Focus, Multiple | | 10 2.2|
Fatty Change | 1 | 7 2.3|
Inflammation | | 1 2.0|
Mixed Cell Focus | | 2 2.0|
Mixed Cell Focus, Multiple | | 2 2.0|
Necrosis | | 2 1.5|
Bile Duct, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Ectopic Liver | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Acinar Cell, Atrophy | 1 1 2 1 1 | 36 1.6|
Artery, Inflammation | | 2 3.5|
Duct, Ectasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Hyperplasia | | 5 2.4|
Inflammation | | 3 3.0|
Ulcer | | 2 2.0|
Ulcer, Multiple | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 56 |
Inflammation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
75 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 2 1 1 1 1 1 | 55 1.6|
Atrium, Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Angiectasis | | 1 2.0|
Degeneration | | 1 2.0|
Hyperplasia | | 6 1.7|
Hypertrophy | | 2 2.5|
Vacuolization Cytoplasmic | | 15 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 56 |
Hyperplasia | | 19 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 5 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 48 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 56 |
Pars Distalis, Angiectasis | | 4 2.8|
Pars Distalis, Cyst | 1 | 4 2.3|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 1 1 2 | 25 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 56 |
Atrophy | | 1 2.0|
Granuloma Sperm | | 1 3.0|
Hypospermia | | 25 3.3|
Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
75 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Degeneration | | 1 2.0|
Ectasia | 2 2 3 2 2 2 | 49 2.1|
Hyperplasia | | 3 3.3|
Inflammation | 1 2 2 2 2 | 12 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 56 |
Concretion | 1 1 1 | 7 1.1|
Congestion | 1 | 1 1.0|
Hyperplasia | | 6 1.2|
Inflammation | 1 1 1 | 23 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 56 |
Depletion Cellular | | 23 2.9|
__________________________________________________________________________|____________|
Testes | + + + + + + | 56 |
Atrophy | | 6 2.3|
Arteriole, Inflammation | | 10 2.0|
Bilateral, Atrophy | | 4 3.0|
Interstitial Cell, Hyperplasia | 1 1 | 12 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Hemorrhage | | 1 3.0|
Hyperplasia | 1 | 8 1.6|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + | 40 |
Hemorrhage | 1 1 2 1 1 | 18 1.4|
Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 56 |
Cyst | | 2 2.5|
Hemorrhage | 1 | 7 1.6|
Hyperplasia, Plasma Cell | | 6 2.3|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 56 |
Hemorrhage | 1 | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 52 |
Hemorrhage | 2 1 1 2 2 1 | 33 1.7|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Pigmentation | | 13 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Degeneration, Cystic | | 2 2.0|
Fibrosis | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
75 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 5 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 55 |
Atrophy | 2 1 1 1 | 42 1.9|
Hemorrhage | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
Lactation | | 10 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Compression | | 6 2.7|
Hemorrhage | | 1 2.0|
Hydrocephalus | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation | 1 2 | 4 1.5|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Congestion | | 3 2.3|
Hemorrhage | 1 | 4 1.3|
Inflammation | | 3 1.7|
Alveolar Epithelium, Hyperplasia | | 28 1.8|
Arteriole, Inflammation | | 1 2.0|
Artery, Inflammation | | 1 2.0|
Artery, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 56 |
Angiectasis | | 1 3.0|
Foreign Body | 1 | 3 1.7|
Hemorrhage | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
75 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation | 1 | 7 1.6|
Goblet Cell, Hyperplasia | 1 | 3 1.3|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | | 2 1.5|
Respiratory Epithelium, Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Hemorrhage | | 1 3.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Nephropathy, Chronic | 1 1 2 1 1 2 | 55 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 6| 3| 3| 3| 2| 1| 2| 2| 3| 2| 2| 8| 1| 2| 2| 3| 2| 2| 2| 2| 3|
| 0| 4| 6| 0| 4| 0| 0| 0| 2| 1| 9| 9| 0| 9| 9| 9| 0| 9| 1| 0| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 |
Basophilic Focus, Multiple | 2 2 2 2 2 3 2 1|
Clear Cell Focus | 2 |
Clear Cell Focus, Multiple | 1 |
Congestion | 3 2 3 2 |
Degeneration, Cystic | 1 1 |
Eosinophilic Focus | 2 1 |
Eosinophilic Focus, Multiple | 2 2 |
Fatty Change | 3 1 2 1 1 4 2|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | |
Mixed Cell Focus | 3 2 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Acinar Cell, Atrophy | 2 2 2 2 3 2 4 1 3 3 3 1 1 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation | |
Ulcer | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 6| 3| 3| 3| 2| 1| 2| 2| 3| 2| 2| 8| 1| 2| 2| 3| 2| 2| 2| 2| 3|
| 0| 4| 6| 0| 4| 0| 0| 0| 2| 1| 9| 9| 0| 9| 9| 9| 0| 9| 1| 0| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 2 3 2 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 2|
Atrium, Dilatation | 2 |
Atrium, Thrombosis | 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cytoplasmic Alteration | 2 |
Degeneration | 3 2 |
Hyperplasia | 2 2 2 |
Hypertrophy | 2 |
Vacuolization Cytoplasmic | 2 1 2 2 2 1 3 3 1 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Hypospermia | 3 4 2 4 4 4 2 4 4 4 3 4 3 4|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Ectasia | 2 3 2 1 2 2 2 2 2 3 3 2 3 1 2 1 |
Hyperplasia | |
Inflammation | 2 3 2 1 1 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1 2 2 2 |
Hyperplasia | 2 2 1|
Inflammation | 2 2 2 3 3 2 2 1 2 3 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 3 3 3 3 4 3 4 3 3 4 3 3 2 3 4 3 |
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 6| 3| 3| 3| 2| 1| 2| 2| 3| 2| 2| 8| 1| 2| 2| 3| 2| 2| 2| 2| 3|
| 0| 4| 6| 0| 4| 0| 0| 0| 2| 1| 9| 9| 0| 9| 9| 9| 0| 9| 1| 0| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 4 2 |
Hypospermia | 3 |
Arteriole, Inflammation | 2 |
Bilateral, Atrophy | 4 |
Interstitial Cell, Hyperplasia | 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | 4 2 1 3 2 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node | + |
Deep Cervical, Inflammation | 2 |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + M M M M M M M + + M + + + M + +|
Hemorrhage | 1 2 2 2 2 2 1 |
Infiltration Cellular, Histiocyte | |
Pigmentation | 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 3 3 2 1|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hemorrhage | 1 2 1 3 2 3 1 2 3 1 2 1 1 3 2|
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 2 2 2 1 1 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Cystic | 1 2 3 |
Developmental Malformation | |
Hematopoietic Cell Proliferation | 2 3 2 3 2 2 2 |
Inflammation | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 3 3 3 2 2 1 2 2 2 2 1 3 1 1 2 4 1 3 |
Congestion | 3 |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 6| 3| 3| 3| 2| 1| 2| 2| 3| 2| 2| 8| 1| 2| 2| 3| 2| 2| 2| 2| 3|
| 0| 4| 6| 0| 4| 0| 0| 0| 2| 1| 9| 9| 0| 9| 9| 9| 0| 9| 1| 0| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + M + + + + + + + + + + + + + +|
Galactocele | 3 3 3 |
Hyperplasia | 2 |
Inflammation | |
Lactation | 3 3 2 2 2 2 3 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | 3 |
Tail, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 1 3 2 2 1 2 2 2 2 2 2|
Hemorrhage | 1 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Inflammation | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 2 3 2 1 1 2 2 2 2 2 3 2 3 3 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Foreign Body | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 2 2 1 2 1|
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 3 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | |
Respiratory Epithelium, Hyperplasia | 2 1|
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 6| 3| 3| 3| 2| 1| 2| 2| 3| 2| 2| 8| 1| 2| 2| 3| 2| 2| 2| 2| 3|
| 0| 4| 6| 0| 4| 0| 0| 0| 2| 1| 9| 9| 0| 9| 9| 9| 0| 9| 1| 0| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | |
Nephropathy, Chronic | 3 2 1 2 2 2 2 2 2 2 2 3 3 2 2 1 2 2 2 2 2 2 3 3|
Pigmentation | 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 1| 2| 2| 6| 9| 1| 3| 3| 2| 8| 3| 2| 3| 4| 2| 2| 4| 2| 3| 2| 3| 5| 5| 5| 5|
| 7| 9| 3| 7| 9| 1| 0| 0| 8| 2| 0| 9| 0| 0| 9| 9| 7| 9| 0| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + + + + + + + + + + A + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Hyperplasia | 3 |
Inflammation | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 2 |
Basophilic Focus, Multiple | 2 2 2 1 1 2 1 2 2 2 1|
Clear Cell Focus | |
Clear Cell Focus, Multiple | 2 2 |
Congestion | 1 2 |
Degeneration, Cystic | 2 2 |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | 2 1 |
Fatty Change | 1 3 2 2 3 1 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation | 3 |
Mixed Cell Focus | 2 2 |
Necrosis | 3 4 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Acinar Cell, Atrophy | 1 2 1 3 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 1| 2| 2| 6| 9| 1| 3| 3| 2| 8| 3| 2| 3| 4| 2| 2| 4| 2| 3| 2| 3| 5| 5| 5| 5|
| 7| 9| 3| 7| 9| 1| 0| 0| 8| 2| 0| 9| 0| 0| 9| 9| 7| 9| 0| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 3 1 1 2 3 2 1 1 1 3 2 2 2 3 3 2 2 2 2 1 2 2 2|
Atrium, Dilatation | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cytoplasmic Alteration | |
Degeneration | |
Hyperplasia | |
Hypertrophy | 2 |
Vacuolization Cytoplasmic | 1 2 3 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 4 2 |
Pars Distalis, Cyst | 4 2 |
Pars Distalis, Hyperplasia | 2 1 3 2 3 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Hypospermia | 3 4 3 3 3 4 4 4 3 4 4 3 4 4 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Ectasia | 3 2 2 2 2 2 3 3 2 2 2 2 3 2 3 2 3 2 2|
Hyperplasia | 3 |
Inflammation | 1 2 1 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 2 1 1|
Hyperplasia | 1 |
Inflammation | 2 3 2 2 3 1 3 2 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 4 2 3 3 4 3 2 1 3 2 3 2 3 4 |
Ectasia | 3 |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 1| 2| 2| 6| 9| 1| 3| 3| 2| 8| 3| 2| 3| 4| 2| 2| 4| 2| 3| 2| 3| 5| 5| 5| 5|
| 7| 9| 3| 7| 9| 1| 0| 0| 8| 2| 0| 9| 0| 0| 9| 9| 7| 9| 0| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation | 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 |
Hypospermia | |
Arteriole, Inflammation | 3 3 1 3 |
Bilateral, Atrophy | 3 3 4 2 3 3 |
Interstitial Cell, Hyperplasia | 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | 2 2 3 2 2 2 1 2 1|
Pigmentation | |
__________________________________________________________________________|
Lymph Node | |
Deep Cervical, Inflammation | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + M M M + + M + + M + + M + + + +|
Hemorrhage | 3 4 2 3 1 1 2|
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hemorrhage | 4 3 2 1 1 1 2 3 2 2 3 2 3 3 2|
Hyperplasia, Plasma Cell | 3 3 |
Infiltration Cellular, Histiocyte | 2 |
Pigmentation | 2 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Degeneration, Cystic | 3 2 |
Developmental Malformation | 1 |
Hematopoietic Cell Proliferation | 2 1 1 3 1 1 |
Inflammation | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 3 2 4 2 2 3 2 3 2 2 1 2 2 1|
Congestion | 3 |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 1| 2| 2| 6| 9| 1| 3| 3| 2| 8| 3| 2| 3| 4| 2| 2| 4| 2| 3| 2| 3| 5| 5| 5| 5|
| 7| 9| 3| 7| 9| 1| 0| 0| 8| 2| 0| 9| 0| 0| 9| 9| 7| 9| 0| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Galactocele | 3 |
Hyperplasia | |
Inflammation | 2 |
Lactation | 1 1 2 3 3 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | |
Tail, Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 1 2 1 3 3 2 3 |
Hemorrhage | |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | 1 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage | 1 1|
Infiltration Cellular, Histiocyte | 2 |
Inflammation | 2 3 2 1 2 |
Alveolar Epithelium, Hyperplasia | 2 2 1 2 2 2 2 2 3 2 3 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Foreign Body | 3 2|
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 4 2 1 1 2|
Goblet Cell, Hyperplasia | 1 |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 1 1 |
Respiratory Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4|
DAY ON TEST | 1| 2| 2| 6| 9| 1| 3| 3| 2| 8| 3| 2| 3| 4| 2| 2| 4| 2| 3| 2| 3| 5| 5| 5| 5|
| 7| 9| 3| 7| 9| 1| 0| 0| 8| 2| 0| 9| 0| 0| 9| 9| 7| 9| 0| 9| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 4 2 4 |
Nephropathy, Chronic | 2 3 2 2 1 1 2 3 2 3 3 3 2 3 2 2 2 3 2 2 2 1 1 1 1|
Pigmentation | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
150 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 55 |
Infiltration Cellular, Lipocyte | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 55 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 53 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 55 |
Ectopic Tissue | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | 1 1 | 7 1.1|
Basophilic Focus, Multiple | 1 1 1 | 22 1.7|
Clear Cell Focus | 1 | 2 1.5|
Clear Cell Focus, Multiple | | 3 1.7|
Congestion | 2 | 7 2.1|
Degeneration, Cystic | | 4 1.5|
Eosinophilic Focus | | 2 1.5|
Eosinophilic Focus, Multiple | | 4 1.8|
Fatty Change | | 14 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | | 1 3.0|
Mixed Cell Focus | | 4 2.3|
Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Fat, Necrosis | 3 2 | 8 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Inflammation | | 2 1.5|
Acinar Cell, Atrophy | 3 2 2 2 2 | 32 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Hyperplasia | | 3 2.3|
Inflammation | | 1 3.0|
Ulcer | | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
150 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation | | 2 1.5|
Ulcer | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 2 1 1 1 2 | 51 1.9|
Atrium, Dilatation | | 1 2.0|
Atrium, Thrombosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Congestion | | 1 2.0|
Cytoplasmic Alteration | | 1 2.0|
Degeneration | | 2 2.5|
Hyperplasia | | 3 2.0|
Hypertrophy | | 2 2.0|
Vacuolization Cytoplasmic | | 16 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 56 |
Hyperplasia | | 12 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 5 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 55 |
Pars Distalis, Angiectasis | | 4 2.8|
Pars Distalis, Cyst | | 3 2.7|
Pars Distalis, Hyperplasia | 1 2 2 1 | 18 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 56 |
Granuloma Sperm | | 1 3.0|
Hypospermia | | 29 3.6|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 56 |
Abscess | | 1 3.0|
Ectasia | 2 2 2 2 3 2 | 41 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
150 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
Inflammation | 2 | 16 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 56 |
Concretion | 1 1 | 10 1.5|
Hyperplasia | | 4 1.5|
Inflammation | 2 2 2 2 2 | 25 2.2|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 56 |
Depletion Cellular | | 31 3.0|
Ectasia | | 1 3.0|
Inflammation | | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + | 56 |
Atrophy | 3 | 8 2.8|
Hypospermia | | 1 3.0|
Arteriole, Inflammation | | 5 2.4|
Bilateral, Atrophy | | 7 3.1|
Interstitial Cell, Hyperplasia | 1 | 14 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Congestion | | 1 2.0|
Hyperplasia | | 15 2.1|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Deep Cervical, Inflammation | | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 39 |
Hemorrhage | 2 1 2 3 | 18 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Pigmentation | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 56 |
Hemorrhage | | 3 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 4 2.3|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 54 |
Hemorrhage | | 7 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 55 |
Depletion Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
150 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 2 3 1 1 2 3 | 36 2.1|
Hyperplasia, Plasma Cell | | 2 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Pigmentation | | 12 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 55 |
Congestion | | 1 3.0|
Degeneration, Cystic | | 5 2.2|
Developmental Malformation | | 1 1.0|
Hematopoietic Cell Proliferation | | 13 1.9|
Inflammation | | 1 4.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 54 |
Atrophy | 1 1 1 1 1 | 41 2.0|
Congestion | | 2 3.0|
Cyst | | 1 2.0|
Hemorrhage | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 53 |
Galactocele | | 4 3.0|
Hyperplasia | | 1 2.0|
Inflammation | | 1 2.0|
Lactation | | 16 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Subcutaneous Tissue, Abscess | | 1 3.0|
Tail, Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Compression | | 22 2.1|
Hemorrhage | | 1 1.0|
Hydrocephalus | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Foreign Body | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05185-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYL NITRITE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:24:48
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
150 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | | 2 1.5|
Inflammation | 1 | 4 1.5|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Congestion | | 3 2.0|
Hemorrhage | 1 | 3 1.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation | | 6 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 1 1 2 | 38 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + | 56 |
Angiectasis | | 2 2.5|
Foreign Body | | 2 2.5|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 2 2.0|
Inflammation | 1 | 11 1.7|
Goblet Cell, Hyperplasia | | 1 1.0|
Nasolacrimal Duct, Inflammation | | 2 2.5|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 | 5 1.2|
Respiratory Epithelium, Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Congestion | | 1 2.0|
Cyst | | 3 3.3|
Nephropathy, Chronic | 1 1 1 1 1 1 | 55 2.0|
Pigmentation | | 5 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 55 |
Dilatation | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
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---------- END OF REPORT ----------
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