TDMS Study 05185-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IITRI ISOBUTYL NITRITE (IBN) DATE: 05/20/95
EXPERIMENT: 05185 TEST: 03 TIME: 11:03:25
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01 ES 65143 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61052B
PATHOLOGIST: RICHARD LONG CAS: 542-56-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IITRI ISOBUTYL NITRITE (IBN) DATE: 05/20/95
EXPERIMENT: 05185 TEST: 03 TIME: 11:03:25
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01 ES 65143 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61052B
PATHOLOGIST: RICHARD LONG CAS: 542-56-3
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 29 CENSORED DEATHS 10 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 415 427 495 498 525 532 533 563 583 611 |
| 617 624 631 639 639 640 641 644 654 665 |
| 666 666 666 667 681 684 692 695 726 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 37.5 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 23 CENSORED DEATHS 10 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 353 436 471 551 555 568 576 636 645 645 |
| 646 651 663 672 675 682 695 695 700 701 |
| 702 718 720 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 9 CENSORED DEATHS 11 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 540 552 606 631 667 684 703 712 719 |
| CENSORED DEATHS |
| 200 456 456 456 456 456 456 456 456 456 |
| 456 |
| |
==================================================================================
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 150 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 330 523 564 582 589 604 610 611 611 636 |
| 640 647 667 699 717 721 722 728 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.2 96.4 85.5 81.1 57.0 37.3 |
| | |
| | |
|37.5 PPM | 100.0 100.0 100.0 98.2 98.2 94.2 94.2 85.5 72.3 50.4 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 97.8 95.6 91.1 80.0 |
| | |
| | |
|150 PPM | 100.0 100.0 100.0 98.2 98.2 98.2 96.0 87.3 74.2 61.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 37.5 PPM 75 PPM 150 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 37.3% 50.4% 80.0% 61.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.009N P=0.152N P<0.001 P=0.029N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 611.0 624.2 646.0 622.3 |
|NATURAL DEATHS (C) | (14.9) (20.2) (22.6) (22.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 619.1 637.2 657.5 645.9 |
|(STANDARD ERROR) | (14.6) (15.4) (16.5) (15.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 464 516 526 602 604 640 640 641 646 652 |
| 658 666 668 671 702 720 721 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 37.5 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 10 CENSORED DEATHS 11 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 378 477 624 645 648 659 672 686 720 729 |
| CENSORED DEATHS |
| 176 457 457 457 457 457 457 457 457 457 |
| 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 316 377 504 604 610 636 647 650 653 674 |
| 686 705 708 726 730 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 150 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 13 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 234 394 483 500 533 608 617 622 630 674 |
| 681 696 705 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
ISOBUTYL NITRITE (IBN)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 97.8 93.5 89.1 76.1 63.0 |
| | |
| | |
|37.5 PPM | 100.0 100.0 100.0 100.0 98.2 96.0 96.0 96.0 87.0 78.1 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 98.2 96.4 96.4 94.2 92.0 81.1 67.9 |
| | |
| | |
|150 PPM | 100.0 100.0 98.2 98.2 96.4 94.2 89.9 89.9 81.1 72.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 37.5 PPM 75 PPM 150 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.0% 78.1% 67.9% 72.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.783N P=0.167N P=0.764N P=0.573N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 631.6 623.8 615.1 567.5 |
|NATURAL DEATHS (C) | (17.2) (35.1) (31.9) (38.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 652.9 654.3 652.1 645.3 |
|(STANDARD ERROR) | (14.6) (17.6) (16.3) (17.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ISOBUTYL NITRITE (IBN)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
37.5 PPM = 2
75 PPM = 3
150 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1 3
| 4 2 11 2 2 1 4 33
| 2 11 4 2 4 4 3
| 1 1 22 4 4 3 3
90 + 11 2 2 4 4 3 3 3
| 11 22 44 3 3
P | 1 1 2 2 33
E | 1 1 2 2 33
R 80 + 1 11 4 3 3
C | 11444
E | 11 2 24
N | 11 22 4
T 70 + 22 4 4
| 22
S | 2 2 44
U | 1 1
R 60 + 1 1 22 4 4
V | 11
I | 2 2
V |
A 50 + 2 2
L | 1 1
| 11
| 11
40 + 1 1
| 1 1
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
ISOBUTYL NITRITE (IBN)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
37.5 PPM = 2
75 PPM = 3
150 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 2 1
| 4 3 2 4 2
| 1 1
| 3 4 2 3 1 1 2
95 +
| 4 3 1 13 2 2
| 4 4 33
| 11
P 90 + 4 43 3
E | 1 12 2
R | 4 4 3 3 22
C |
E 85 + 2 2
N | 44 33
T | 11 2 2
| 4 3 3
S 80 + 11 2 2
U | 33
R | 2
V | 1 1 3 43
I 75 + 433
V |
A | 43 3 4
L |
70 + 1 1 3 3
|
| 1 1 3
|
65 +
|
| 1 1
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.