TDMS Study 05186-03 Pathology Tables

NTP Experiment-Test: 05186-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98
Route: GAVAGE                                                                                                     Time: 14:08:06
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  78-44-4
       Lock Date:  04/13/93
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05186-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:08:06  
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         FISCHER 344 RATS FEMALE                   0 MG/KG      100          200          400          800                          
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                                                             2            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10            8            9                        
  Animals Examined Microscopically                    10           10           10           10           10                        
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 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)                      (1)          (2)          (9)                       
      Hepatodiaphragmatic Nodule                                                                           2 (22%)                  
      Inflammation, Chronic, Focal                                               1 (100%)                                           
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
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 HEMATOPOIETIC SYSTEM                                                                                                               
   Thymus                                                                                    (2)          (1)                       
      Hemorrhage                                                                              2 (100%)                              
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:08:06  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      100          200          400          800                          
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                                                                      (2)          (1)                       
      Congestion                                                                                           1 (100%)                 
   Nose                                                                                      (2)          (1)                       
      Respiratory Epithelium, Hemorrhage                                                                   1 (100%)                 
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (9)                       
      Mineralization                                   9 (90%)     10 (100%)    10 (100%)    10 (100%)     8 (89%)                  
      Nephropathy                                      2 (20%)      2 (20%)      3 (30%)      1 (10%)      5 (56%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:08:06  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      100          200          400          800                          
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                                                                          2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10            8                        
  Animals Examined Microscopically                    10           10           10           10           10                        
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (1)                                    (10)                      
      Congestion                                                                                           2 (20%)                  
      Hepatodiaphragmatic Nodule                       3 (30%)                                                                      
      Inflammation, Chronic, Focal                                  1 (100%)                                                        
      Necrosis                                                                                             1 (10%)                  
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Thymus                                                                                                 (2)                       
      Hemorrhage                                                                                           2 (100%)                 
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:08:06  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      100          200          400          800                          
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                                                                                   (2)                       
      Congestion                                                                                           1 (50%)                  
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)                      
      Nephropathy                                     10 (100%)     9 (90%)     10 (100%)    10 (100%)    10 (100%)                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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