TDMS Study 05187-06 Pathology Tables
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 93-15-2
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 5 7 8 13
Natural Death 14 24 23 35
Dosing Accident 1 1
Survivors
Natural Death 2
Terminal Sacrifice 31 18 16 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (38) (28) (30) (24)
Infiltration Cellular, Lymphocyte 1 (4%)
Intestine Small, Duodenum (46) (49) (46) (43)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%)
Epithelium, Necrosis 1 (2%)
Intestine Small, Jejunum (46) (46) (40) (40)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Liver (50) (50) (49) (50)
Atrophy 1 (2%)
Basophilic Focus 5 (10%) 2 (4%) 3 (6%)
Clear Cell Focus 1 (2%) 2 (4%) 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 5 (10%) 9 (18%) 4 (8%) 9 (18%)
Fibrosis 1 (2%) 2 (4%) 3 (6%)
Hematopoietic Cell Proliferation 4 (8%) 14 (28%) 23 (47%) 24 (48%)
Infiltration Cellular, Lymphocyte 23 (46%) 18 (36%) 21 (43%) 19 (38%)
Inflammation, Chronic Active 24 (48%) 25 (50%) 16 (33%) 10 (20%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%) 2 (4%)
Mixed Cell Focus 7 (14%) 3 (6%)
Pigmentation, Hemosiderin 11 (22%) 24 (49%) 19 (38%)
Tension Lipidosis 2 (4%)
Bile Duct, Cyst 1 (2%) 6 (12%) 3 (6%)
Bile Duct, Cyst, Multiple 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%) 11 (22%) 9 (18%)
Hepatocyte, Atypia Cellular 1 (2%)
Hepatocyte, Hyperplasia, Adenomatous 1 (2%)
Hepatocyte, Necrosis 5 (10%) 9 (18%) 16 (33%) 17 (34%)
Hepatocyte, Vacuolization Cytoplasmic 20 (40%) 14 (28%) 11 (22%) 12 (24%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Centrilobular, Atrophy 1 (2%)
Oval Cell, Hyperplasia 46 (92%) 36 (73%) 38 (76%)
Portal, Hypertrophy 10 (20%) 7 (14%) 23 (46%)
Mesentery (13) (7) (3) (3)
Inflammation, Chronic Active 1 (8%)
Inflammation, Suppurative 1 (33%)
Artery, Inflammation, Chronic Active 1 (14%)
Artery, Necrosis, Fibrinoid 1 (14%)
Fat, Necrosis 6 (46%) 3 (43%) 1 (33%) 1 (33%)
Pancreas (49) (50) (46) (46)
Infiltration Cellular, Lymphocyte 10 (20%) 15 (30%) 13 (28%) 2 (4%)
Acinus, Atrophy 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Salivary Glands (50) (45) (44) (42)
Infiltration Cellular, Lymphocyte 33 (66%) 29 (64%) 27 (61%) 18 (43%)
Stomach, Forestomach (50) (50) (48) (46)
Diverticulum 1 (2%)
Hyperkeratosis 1 (2%) 3 (6%) 3 (7%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Epithelium, Hyperplasia, Squamous 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Epithelium, Ulcer 2 (4%)
Stomach, Glandular (45) (49) (46) (45)
Atrophy 10 (22%) 10 (22%)
Ectasia 14 (31%) 33 (67%) 31 (67%) 38 (84%)
Hyperplasia 1 (2%) 5 (11%) 2 (4%)
Hyperplasia, Atypical 1 (2%)
Inflammation, Chronic Active 17 (38%) 21 (43%) 12 (26%) 14 (31%)
Mineralization 2 (4%) 1 (2%) 2 (4%) 3 (7%)
Necrosis 1 (2%) 3 (7%) 2 (4%)
Neuroendocrine Cell, Hyperplasia 1 (2%)
Tooth (2) (1)
Inflammation, Chronic Active 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (49) (47)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Heart (50) (50) (48) (44)
Inflammation, Chronic Active 1 (2%)
Mineralization 2 (4%) 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Atrium, Thrombosis 1 (2%) 3 (6%) 6 (13%) 9 (20%)
Valve, Inflammation, Suppurative 1 (2%)
Valve, Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Degeneration, Fatty 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 8 (16%) 17 (34%) 14 (29%)
Pigmentation, Hemosiderin 1 (2%)
Subcapsular, Hyperplasia 47 (94%) 48 (96%) 49 (98%) 48 (98%)
Adrenal Medulla (50) (50) (50) (49)
Hyperplasia 1 (2%) 7 (14%) 5 (10%)
Islets, Pancreatic (49) (50) (46) (47)
Hyperplasia 8 (16%) 3 (6%) 1 (2%) 2 (4%)
Parathyroid Gland (36) (40) (38) (36)
Cyst 1 (3%) 1 (3%)
Pituitary Gland (48) (44) (44) (40)
Pars Distalis, Angiectasis 7 (15%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (3%)
Pars Distalis, Hyperplasia 6 (13%) 8 (18%) 3 (7%) 3 (8%)
Thyroid Gland (50) (46) (46) (42)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic Active 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 8 (16%) 10 (22%) 7 (15%) 5 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (47) (46) (44)
Cyst 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Ovary (50) (49) (48) (41)
Angiectasis 1 (2%) 1 (2%)
Cyst 12 (24%) 7 (14%) 7 (15%) 4 (10%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Mineralization 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 2 (5%)
Uterus (50) (50) (49) (47)
Hemorrhage 1 (2%)
Hydrometra 25 (50%) 24 (48%) 15 (31%) 5 (11%)
Hyperplasia, Cystic 19 (38%) 10 (20%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (48) (50)
Hyperplasia 18 (36%) 47 (94%) 46 (96%) 50 (100%)
Myelofibrosis 10 (20%) 7 (14%) 3 (6%) 3 (6%)
Lymph Node (13) (7) (8) (4)
Inguinal, Infiltration Cellular, Mast Cell 1 (25%)
Lumbar, Ectasia 1 (14%)
Mediastinal, Hyperplasia, Lymphoid 2 (15%)
Mediastinal, Necrosis 1 (14%)
Pancreatic, Hyperplasia 1 (14%)
Renal, Ectasia 1 (8%)
Lymph Node, Mandibular (49) (43) (41) (32)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (47) (48) (43) (36)
Angiectasis 1 (2%) 1 (2%)
Ectasia 1 (2%) 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Necrosis 1 (2%) 1 (2%)
Spleen (50) (50) (46) (46)
Atrophy 1 (2%)
Fibrosis 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Lymphoid Follicle, Depletion Cellular 1 (2%) 2 (4%)
Lymphoid Follicle, Hyperplasia, Lymphoid 8 (16%) 3 (6%) 2 (4%)
Lymphoid Follicle, Necrosis 2 (4%) 4 (9%) 1 (2%)
Red Pulp, Hematopoietic Cell Proliferation 29 (58%) 40 (80%) 45 (98%) 44 (96%)
Thymus (45) (43) (40) (33)
Cyst 14 (31%) 9 (21%) 5 (13%) 7 (21%)
Ectopic Parathyroid Gland 1 (3%)
Thymocyte, Necrosis 2 (5%) 3 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (50) (37)
Hyperplasia, Cystic 1 (2%) 1 (2%)
Skin (50) (50) (50) (49)
Subcutaneous Tissue, Infiltration Cellular,
Lymphocyte 1 (2%) 2 (4%) 2 (4%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (8) (3) (3)
Infiltration Cellular, Lymphocyte 5 (63%) 1 (33%) 2 (67%)
Artery, Inflammation, Chronic Active 1 (13%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Peripheral Nerve (1)
Demyelination 1 (100%)
Spinal Cord (1)
Demyelination 1 (100%)
Artery, Inflammation, Chronic Active 1 (100%)
Artery, Necrosis, Fibrinoid 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (48) (45)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 2 (4%) 4 (9%)
Bronchiole, Exudate, Organized 1 (2%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
Mediastinum, Necrosis 1 (2%)
Nose (50) (50) (49) (47)
Inflammation, Suppurative 8 (16%) 11 (22%) 13 (27%) 11 (23%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 15 (30%) 11 (22%) 12 (26%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1)
Atrophy 1 (100%)
Hemorrhage 1 (50%)
Inflammation, Suppurative 1 (50%)
Cornea, Inflammation, Chronic Active 1 (50%)
Harderian Gland (5) (2) (2)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Accumulation, Hyaline Droplet 1 (2%) 3 (6%)
Hydronephrosis 2 (4%)
Infiltration Cellular, Lymphocyte 28 (56%) 29 (58%) 29 (58%) 23 (47%)
Metaplasia, Osseous 2 (4%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 3 (6%) 2 (4%) 2 (4%)
Necrosis 1 (2%)
Nephropathy 10 (20%) 13 (26%) 9 (18%) 10 (20%)
Artery, Inflammation, Chronic Active 2 (4%)
Cortex, Cyst 1 (2%) 2 (4%)
Glomerulus, Amyloid Deposition 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin 2 (4%) 2 (4%)
Urinary Bladder (50) (49) (47) (46)
Infiltration Cellular, Lymphocyte 20 (40%) 29 (59%) 27 (57%) 25 (54%)
Inflammation, Chronic Active 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 5 6 5 9
Natural Death 6 8 7 4
Accidently Killed 1 1
Dosing Accident 1
Survivors
Terminal Sacrifice 38 36 37 35
Missing 1
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (47) (47) (48) (50)
Inflammation, Chronic Active 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (49) (49) (48) (48)
Inflammation, Chronic Active 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Peyer's Patch, Inflammation, Suppurative 1 (2%)
Liver (49) (50) (50) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Basophilic Focus 5 (10%) 3 (6%) 1 (2%) 3 (6%)
Clear Cell Focus 16 (33%) 8 (16%) 2 (4%) 6 (12%)
Eosinophilic Focus 10 (20%) 20 (40%) 25 (50%) 19 (38%)
Fibrosis 1 (2%) 4 (8%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 9 (18%) 7 (14%) 9 (18%)
Infiltration Cellular, Lymphocyte 6 (12%) 5 (10%) 12 (24%) 10 (20%)
Inflammation, Chronic Active 19 (39%) 21 (42%) 28 (56%) 28 (56%)
Mineralization 3 (6%) 1 (2%)
Mixed Cell Focus 9 (18%) 13 (26%) 9 (18%) 7 (14%)
Pigmentation, Hemosiderin 3 (6%) 5 (10%) 6 (12%) 5 (10%)
Tension Lipidosis 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%)
Hepatocyte, Necrosis 8 (16%) 14 (28%) 8 (16%) 10 (20%)
Hepatocyte, Vacuolization Cytoplasmic 7 (14%) 7 (14%) 2 (4%) 13 (26%)
Hepatocyte, Centrilobular, Atrophy 1 (2%)
Hepatocyte, Centrilobular, Necrosis 2 (4%)
Oval Cell, Hyperplasia 8 (16%) 27 (54%) 46 (92%)
Portal, Hypertrophy 1 (2%) 7 (14%) 46 (92%)
Mesentery (1) (2) (1) (1)
Thrombosis 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 1 (100%)
Pancreas (49) (49) (50) (50)
Cyst 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 4 (8%) 4 (8%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 3 (6%)
Artery, Inflammation, Chronic Active 1 (2%)
Salivary Glands (49) (50) (50) (50)
Atrophy 1 (2%)
Infiltration Cellular, Lymphocyte 31 (63%) 29 (58%) 28 (56%) 34 (68%)
Stomach, Forestomach (49) (50) (50) (50)
Hyperkeratosis 1 (2%) 4 (8%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic Active 2 (4%) 3 (6%)
Epithelium, Hyperplasia, Squamous 5 (10%) 2 (4%) 3 (6%) 2 (4%)
Epithelium, Ulcer 1 (2%)
Stomach, Glandular (49) (48) (49) (50)
Atrophy 3 (6%) 35 (71%) 45 (90%)
Ectasia 13 (27%) 25 (52%) 40 (82%) 49 (98%)
Hyperplasia 1 (2%) 15 (31%) 20 (40%)
Hyperplasia, Atypical 1 (2%) 2 (4%)
Inflammation, Chronic Active 10 (20%) 11 (23%) 25 (51%) 33 (66%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%) 1 (2%) 4 (8%)
Necrosis 1 (2%)
Neuroendocrine Cell, Hyperplasia 4 (8%)
Tooth (23) (13) (4) (5)
Inflammation, Chronic Active 1 (4%) 1 (8%) 1 (20%)
Malformation 22 (96%) 12 (92%) 4 (100%) 4 (80%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
Cardiomyopathy 1 (2%) 2 (4%)
Mineralization 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%) 2 (4%)
Valve, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Degeneration, Fatty 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy 5 (10%) 3 (6%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Subcapsular, Hyperplasia 38 (78%) 42 (84%) 44 (88%) 43 (86%)
Islets, Pancreatic (49) (49) (50) (50)
Hyperplasia 32 (65%) 26 (53%) 18 (36%) 17 (34%)
Pituitary Gland (45) (48) (44) (45)
Pars Distalis, Cyst 5 (11%) 7 (15%) 3 (7%) 1 (2%)
Thyroid Gland (49) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 3 (6%)
Follicle, Cyst 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Follicular Cell, Hyperplasia 2 (4%) 7 (14%) 6 (12%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (50) (50)
Cyst 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 2 (4%)
Mineralization 1 (2%)
Preputial Gland (49) (50) (50) (50)
Cyst 7 (14%) 6 (12%) 10 (20%) 5 (10%)
Infiltration Cellular, Lymphocyte 17 (35%) 15 (30%) 14 (28%) 18 (36%)
Inflammation, Chronic Active 3 (6%) 4 (8%) 8 (16%) 2 (4%)
Prostate (49) (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Seminal Vesicle (49) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Testes (49) (50) (50) (50)
Germinal Epithelium, Atrophy 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50) (50)
Atrophy 1 (2%)
Hyperplasia 14 (29%) 26 (53%) 33 (66%) 35 (70%)
Infiltration Cellular, Mast Cell 1 (2%)
Necrosis 1 (2%)
Lymph Node (3) (4) (5) (3)
Lumbar, Hyperplasia, Plasma Cell 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Necrosis 1 (33%)
Renal, Hyperplasia, Plasma Cell 1 (33%)
Lymph Node, Mandibular (48) (46) (47) (45)
Hyperplasia, Lymphoid 2 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Necrosis 1 (2%)
Lymph Node, Mesenteric (49) (46) (49) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Congestion 1 (2%)
Ectasia 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis 2 (4%) 2 (4%) 1 (2%)
Spleen (49) (49) (50) (50)
Atrophy 2 (4%)
Fibrosis 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Lymphoid Follicle, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 3 (6%)
Lymphoid Follicle, Necrosis 3 (6%) 6 (12%) 1 (2%) 2 (4%)
Red Pulp, Erythrophagocytosis 1 (2%)
Red Pulp, Hematopoietic Cell Proliferation 10 (20%) 20 (41%) 25 (50%) 19 (38%)
Thymus (37) (40) (38) (45)
Cyst 10 (27%) 19 (48%) 16 (42%) 12 (27%)
Ectopic Parathyroid Gland 1 (3%) 1 (2%)
Thymocyte, Necrosis 1 (3%) 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (50) (50)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (3) (3)
Infiltration Cellular, Lymphocyte 1 (50%) 2 (67%) 1 (33%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Necrosis 1 (2%)
Spinal Cord (2) (2)
Hemorrhage 1 (50%)
Nerve, Demyelination 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Thrombosis 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 6 (12%) 5 (10%) 5 (10%)
Alveolus, Infiltration Cellular, Lymphocyte 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 2 (4%)
Bronchiole, Hyperplasia 1 (2%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
Mediastinum, Necrosis 1 (2%)
Nose (49) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 9 (18%) 13 (26%) 11 (22%) 10 (20%)
Polyp, Inflammatory 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 2 (4%) 8 (16%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Inflammation, Chronic Active 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Infiltration Cellular, Lymphocyte 29 (59%) 32 (64%) 27 (54%) 40 (80%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%) 3 (6%) 1 (2%)
Mineralization 1 (2%) 3 (6%) 4 (8%)
Necrosis 1 (2%)
Nephropathy 43 (88%) 45 (90%) 45 (90%) 48 (96%)
Artery, Inflammation, Chronic Active 1 (2%)
Cortex, Cyst 10 (20%) 27 (54%) 20 (40%) 14 (28%)
Papilla, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:15:51
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B6C3F1 MICE MALE 0 MG/KG 37 MG/KG 75 MG/KG 150
MG/KG
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URINARY SYSTEM - CONT
Papilla, Necrosis 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Calculus Gross Observation 1 (2%)
Infiltration Cellular, Lymphocyte 6 (12%) 5 (10%) 9 (18%) 14 (28%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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