TDMS Study 05187-06 Pathology Tables
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 93-15-2
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 3| 3| 6| 3| 7| 7| 9| 6| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3|
| 5| 6| 1| 2| 5| 2| 3| 9| 5| 3| 2| 1| 1| 2| 2| 2| 7| 2| 2| 2| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A M + + + + M + A + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X |
Cyst | 3 |
Eosinophilic Focus | X X |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 1 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 2 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1|
Mineralization | |
Mixed Cell Focus | X X X X |
Tension Lipidosis | X X |
Bile Duct, Cyst, Multiple | 3 |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 4 4 2 1 2 3 1 2 1|
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic Active | |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Epithelium, Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + A A + + + + + + + A + + + + + + + +|
Ectasia | 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 2 1 1 |
Mineralization | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 3| 3| 6| 3| 7| 7| 9| 6| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3|
| 5| 6| 1| 2| 5| 2| 3| 9| 5| 3| 2| 1| 1| 2| 2| 2| 7| 2| 2| 2| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 2 |
Subcapsular, Hyperplasia | 2 2 2 2 3 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 3 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + M + M + + M + + M + M M M + M + + + + + + M|
Cyst | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 2|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 3 2 2 3 3 |
Mineralization | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 4 3 2 2 2 2 3 3 |
Hyperplasia, Cystic | 2 3 3 2 2 2 2 2 3 2 2 2|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 3 3 2 |
Myelofibrosis | 1 2 1 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Mediastinal, Hyperplasia, Lymphoid | 2 3 |
Renal, Ectasia | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 3| 3| 6| 3| 7| 7| 9| 6| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3|
| 5| 6| 1| 2| 5| 2| 3| 9| 5| 3| 2| 1| 1| 2| 2| 2| 7| 2| 2| 2| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + M + + +|
Ectasia | 4 |
Infiltration Cellular, Lymphocyte | 3 |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 3 4 2 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 3 1 2 3 4 2 3 2 4 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + M + + + + + + M + + + + +|
Cyst | 2 1 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Infiltration | |
Cellular, Lymphocyte | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 3| 3| 6| 3| 7| 7| 9| 6| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3|
| 5| 6| 1| 2| 5| 2| 3| 9| 5| 3| 2| 1| 1| 2| 2| 2| 7| 2| 2| 2| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
Inflammation, Suppurative | |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 3 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 2 1 1 2 1 1 1 2 1 1 1 |
Metaplasia, Osseous | 1 1 |
Mineralization | |
Nephropathy | 2 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 3 2 1 1|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 1| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 7| 3| 7| 1| 3| 3| 5| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| |
| 2| 8| 0| 2| 8| 0| 1| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 2| 0| 2| 3| 1| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M A + + + + + + + + A + + M M + + + A + + + + + +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + M +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 5 |
Clear Cell Focus | | 1 |
Cyst | | 1 3.0|
Eosinophilic Focus | X X X | 5 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 1 | 4 1.3|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1| 23 1.2|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 | 24 1.0|
Mineralization | 2 | 1 2.0|
Mixed Cell Focus | X X X | 7 |
Tension Lipidosis | | 2 |
Bile Duct, Cyst, Multiple | | 1 3.0|
Bile Duct, Hyperplasia | | 1 2.0|
Hepatocyte, Necrosis | 2 4 2 1 1 | 5 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 4 1 2 1 2 1 1| 20 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 13 |
Inflammation, Chronic Active | 3| 1 3.0|
Fat, Necrosis | 4 4 4 4 | 6 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Epithelium, Hyperplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +| 45 |
Ectasia | 1 1 1 1 1 1 1 | 14 1.0|
Inflammation, Chronic Active | 1 1 1 1 1| 17 1.1|
Mineralization | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Tooth | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 1| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 7| 3| 7| 1| 3| 3| 5| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| |
| 2| 8| 0| 2| 8| 0| 1| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 2| 0| 2| 3| 1| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 2 | 2 2.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2| 47 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 3 | 8 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + M M M + + + + + + + + + + +| 36 |
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Pars Distalis, Angiectasis | 2 2 3 | 7 2.3|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 1 | 8 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst | 2 2 2 2 2 3 3 | 12 2.4|
Mineralization | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 3 3 3 4 2 3 2 3 3 3 4 4 2 3| 25 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 1| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 7| 3| 7| 1| 3| 3| 5| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| |
| 2| 8| 0| 2| 8| 0| 1| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 2| 0| 2| 3| 1| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 4 2 3 3 1 3 3 | 19 2.4|
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 2 3 2 3 3 2 3 | 18 2.7|
Myelofibrosis | 1 2 2 1 2 | 10 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 13 |
Mediastinal, Hyperplasia, Lymphoid | | 2 2.5|
Renal, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Ectasia | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 3 3 3 | 8 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 2 2 2 2 3 2 2 2 2 2 2 3 2 2| 29 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + + + + + + + + + + + + + +| 45 |
Cyst | 2 1 2 2 2 1 2| 14 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Infiltration | | |
Cellular, Lymphocyte | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 1| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 7| 3| 7| 1| 3| 3| 5| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| |
| 2| 8| 0| 2| 8| 0| 1| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 2| 0| 2| 3| 1| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 2 1 1 | 8 1.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 3 | 1 3.0|
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.1|
Metaplasia, Osseous | | 2 1.0|
Mineralization | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1| 10 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 1 1| 20 1.3|
Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 7| 2| 0| 3| 1| 8| 3| 3| 3| 3| 2| 3| 9| 5| 2| 3| 6| 1| 3| 7| 3| 1| 3| 3| 7|
| 7| 1| 5| 1| 9| 7| 2| 2| 2| 2| 7| 2| 3| 2| 0| 1| 2| 6| 2| 5| 2| 7| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + A + + + + + A + + M A + + M M A + A + + +|
Infiltration Cellular, Lymphocyte | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | |
Epithelium, Necrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + A A + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + M + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 4 1 1 2 3 1 |
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 1 2 2 |
Inflammation, Chronic Active | 1 2 1 1 1 2 2 2 3 2 2 2 2 |
Mineralization | |
Mixed Cell Focus | X X X |
Pigmentation, Hemosiderin | 2 1 1 2 2 |
Bile Duct, Cyst | 2 |
Bile Duct, Hyperplasia | |
Hepatocyte, Atypia Cellular | 2 |
Hepatocyte, Necrosis | 3 3 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 1 2 2 1 2 2 |
Oval Cell, Hyperplasia | 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 3 1 2 2 2 2 2|
Portal, Hypertrophy | 2 2 2 1 1 3 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
Fat, Necrosis | 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 2 1 2 1 |
Acinus, Atrophy | |
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + M + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 2 2 1 2 1 2 2 2 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 7| 2| 0| 3| 1| 8| 3| 3| 3| 3| 2| 3| 9| 5| 2| 3| 6| 1| 3| 7| 3| 1| 3| 3| 7|
| 7| 1| 5| 1| 9| 7| 2| 2| 2| 2| 7| 2| 3| 2| 0| 1| 2| 6| 2| 5| 2| 7| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis | 2 2 |
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia, Squamous | 2 |
Epithelium, Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Hyperplasia | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 |
Mineralization | |
Necrosis | |
Neuroendocrine Cell, Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Artery, Inflammation, Chronic Active | |
Atrium, Thrombosis | 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + M + M + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + M + M + + +|
Pars Distalis, Hyperplasia | 1 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active | |
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia | 1 2 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 7| 2| 0| 3| 1| 8| 3| 3| 3| 3| 2| 3| 9| 5| 2| 3| 6| 1| 3| 7| 3| 1| 3| 3| 7|
| 7| 1| 5| 1| 9| 7| 2| 2| 2| 2| 7| 2| 3| 2| 0| 1| 2| 6| 2| 5| 2| 7| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 2 2 3 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 3 2 3 3 4 3 3 1 2 2 2|
Hyperplasia, Cystic | 2 1 2 2 3 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3 3 4 3 3 3|
Myelofibrosis | 1 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Ectasia | 4 |
Mediastinal, Necrosis | |
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | |
Ectasia | 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Depletion Cellular| |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 3 2 |
Lymphoid Follicle, Necrosis | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 3 3 3 3 4 2 2 3 3 4 3 3 4 3 4 4 3 4|
__________________________________________________________________________|
Thymus | + + M + + + + + + + M + + + + + + + + + + + + + +|
Cyst | 1 1 1 2 1 1 1 2 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 7| 2| 0| 3| 1| 8| 3| 3| 3| 3| 2| 3| 9| 5| 2| 3| 6| 1| 3| 7| 3| 1| 3| 3| 7|
| 7| 1| 5| 1| 9| 7| 2| 2| 2| 2| 7| 2| 3| 2| 0| 1| 2| 6| 2| 5| 2| 7| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Peripheral Nerve | |
Demyelination | |
__________________________________________________________________________|
Spinal Cord | |
Demyelination | |
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 1 2 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 3 3 4|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 2 2 1 2 1 1 1 2 |
Metaplasia, Osseous | |
Mineralization | 1 |
Nephropathy | 1 2 2 1 1 1 1 2 1 |
Artery, Inflammation, Chronic Active | 2 |
Cortex, Cyst | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3| |
| 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | M M M + M A + + + M + + + A A A A + + A + A A + +| 28 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
Parasite Metazoan | X | 1 |
Epithelium, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
Inflammation, Suppurative | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | X X | 9 |
Fibrosis | 2 1 | 2 1.5|
Hematopoietic Cell Proliferation | 2 1 2 1 2 2 | 14 1.8|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 1 1 2 2 2| 18 1.6|
Inflammation, Chronic Active | 2 2 1 2 1 1 2 2 1 2 1 2 | 25 1.7|
Mineralization | 1 1 | 2 1.0|
Mixed Cell Focus | | 3 |
Pigmentation, Hemosiderin | 2 2 2 1 2 1| 11 1.6|
Bile Duct, Cyst | | 1 2.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
Hepatocyte, Atypia Cellular | | 1 2.0|
Hepatocyte, Necrosis | 3 3 2 2 2 2 | 9 2.3|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 1 2 | 14 1.6|
Oval Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 1 1 2 2 2 2 2 3 1 2 2 2 2| 46 1.9|
Portal, Hypertrophy | 2 3 3 | 10 2.1|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Necrosis, Fibrinoid | 3 | 1 3.0|
Fat, Necrosis | | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 1 | 15 1.5|
Acinus, Atrophy | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3| |
| 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + M + + + + + M M + + + + + + + +| 45 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 2 2 1 1 2 1 1 1 1 | 29 1.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 3 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Epithelium, Hyperplasia, Squamous | 2 1 | 3 1.7|
Epithelium, Ulcer | 4 | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Ectasia | 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 33 1.1|
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1| 21 1.0|
Mineralization | 2 | 1 2.0|
Necrosis | 1 | 1 1.0|
Neuroendocrine Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Atrium, Thrombosis | 1 | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 1 1 1 2 1 | 8 1.5|
Subcapsular, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2| 48 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + M M + + + + + M M + + + + M + + +| 40 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + I + + I + + + M + + + + + + + + + + + + + + +| 44 |
Pars Distalis, Hyperplasia | 2 2 2 | 8 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3| |
| 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M + + + + + M M + + + + + + + +| 46 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Follicle, Cyst | | 1 3.0|
Follicular Cell, Hyperplasia | 1 1 2| 10 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + M + + + + + + + + + + + + + + + + +| 47 |
Cyst | 2 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Cyst | 2 2 2 4| 7 2.4|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 3 4 2 2 4 3 3 2 2 4| 24 2.6|
Hyperplasia, Cystic | 2 2 2 2 | 10 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3| 47 3.1|
Myelofibrosis | 2 1 1 2| 7 1.4|
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Lumbar, Ectasia | | 1 4.0|
Mediastinal, Necrosis | 2 | 1 2.0|
Pancreatic, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + M + + + M + M M + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 4 | 1 4.0|
Ectasia | 3 | 2 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Follicle, Depletion Cellular| 3 | 1 3.0|
Lymphoid Follicle, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3| |
| 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoid | 3 | 3 2.7|
Lymphoid Follicle, Necrosis | 2 | 2 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 3 3 3 2 3 3 4 3 2 2 2 4 3 2 3 2 3 4 4 4 2 2| 40 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + M + M M + + + M| 43 |
Cyst | 1 | 9 1.2|
Thymocyte, Necrosis | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 8 |
Infiltration Cellular, Lymphocyte | 1 | 5 1.8|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + M + + + + + + M + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
Demyelination | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Demyelination | 1 | 1 1.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 2 1 2 | 11 1.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 2 2 1 2 1| 15 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7| |
DAY ON TEST | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3| |
| 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 3 3.3|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 2 1 1 1 2 1 1 1 1 2| 29 1.3|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 3 2 | 3 2.0|
Nephropathy | 1 1 1 1 | 13 1.2|
Artery, Inflammation, Chronic Active | 3 | 2 2.5|
Cortex, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 2 1 1 2 1 2 2 1 1 1 1 1 1 1| 29 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 6| 5| 6| 6| 7| 5| 6| 4| 5| 7| 7| 5| 6| 5| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 5| 5| 3| 4| 9| 5| 3| 2| 1| 8| 8| 3| 3| 9| 9| 9| 9| 1| 4| 3| 3|
| 1| 3| 1| 8| 8| 9| 7| 5| 0| 2| 1| 0| 1| 9| 2| 2| 2| 0| 4| 7| 4| 7| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A A + + + A A M A + + + A M A M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + A + + + + + + A + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + M + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + M A + + + + + A + + + A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + A + + + + + A A + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Eosinophilic Focus | X X X|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 1 1 2 3 2 2 1 1 2 1 1 1|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 1 1 1|
Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 2|
Pigmentation, Hemosiderin | 1 2 2 2 1 1 2 1 2|
Bile Duct, Cyst | 2 2 2|
Bile Duct, Hyperplasia | 2 1 1 2 1|
Hepatocyte, Necrosis | 4 1 2 3 3 1 3 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 1 1 1 2 1 |
Oval Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2|
Portal, Hypertrophy | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + A + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 2 1 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + M + M + + + + + + + + + + + + + M M + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 2 1 1 2 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 2 1 1 2 2 |
Ectasia | 1 1 2 2 1 1 2 2 1 1 1 1 1 2|
Hyperplasia | 1 2 2|
Inflammation, Chronic Active | 1 1 1 1 1|
Mineralization | 1 1 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Heart | + + + + + + M + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 6| 5| 6| 6| 7| 5| 6| 4| 5| 7| 7| 5| 6| 5| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 5| 5| 3| 4| 9| 5| 3| 2| 1| 8| 8| 3| 3| 9| 9| 9| 9| 1| 4| 3| 3|
| 1| 3| 1| 8| 8| 9| 7| 5| 0| 2| 1| 0| 1| 9| 2| 2| 2| 0| 4| 7| 4| 7| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 3 |
Atrium, Thrombosis | 4 3 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 3 1 1 1 1|
Subcapsular, Hyperplasia | 1 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + A + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + M + + + + + + + M + + + + + + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + M + + + + + + M M + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + M + M + + + + + + + + + + + + + + M + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + A + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | 3 2 2 4 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hydrometra | 3 1 3 2 3 2 2 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3 4 4 3 3 3 3|
Myelofibrosis | 2 1 |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + + + + + + + + M + + + + M M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + M + + + A + + + + + + + M + + +|
Angiectasis | |
Ectasia | |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + A + + + + + + + M + + +|
Fibrosis | 4 |
Lymphoid Follicle, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 6| 5| 6| 6| 7| 5| 6| 4| 5| 7| 7| 5| 6| 5| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 5| 5| 3| 4| 9| 5| 3| 2| 1| 8| 8| 3| 3| 9| 9| 9| 9| 1| 4| 3| 3|
| 1| 3| 1| 8| 8| 9| 7| 5| 0| 2| 1| 0| 1| 9| 2| 2| 2| 0| 4| 7| 4| 7| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoid | |
Lymphoid Follicle, Necrosis | 2 1 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 3 4 3 3 3 2 3 3 3 3 3 3 4 3 3 3 2 3 4 3 3|
__________________________________________________________________________|
Thymus | + + + + M M M + + + + + + + M + + + + + + M + + +|
Cyst | 2 1 |
Thymocyte, Necrosis | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Infiltration | |
Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + M + + + + + + + + + + + + + M M + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + M + + + + + + + + + + + + + + M + + +|
Alveolus, Infiltration Cellular, | |
Histiocyte | 4 |
Bronchiole, Exudate, Organized | 3 |
Mediastinum, Inflammation, Chronic | |
Active | |
Mediastinum, Necrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 1 2 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + M + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 6| 5| 6| 6| 7| 5| 6| 4| 5| 7| 7| 5| 6| 5| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 5| 5| 3| 4| 9| 5| 3| 2| 1| 8| 8| 3| 3| 9| 9| 9| 9| 1| 4| 3| 3|
| 1| 3| 1| 8| 8| 9| 7| 5| 0| 2| 1| 0| 1| 9| 2| 2| 2| 0| 4| 7| 4| 7| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 1 1 2 1 2 2 1 1 1|
Mineralization | 2 |
Necrosis | |
Nephropathy | 1 2 1 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + A + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 2| 6| 2| 3| 1| 6| 3| 9| 5| 2| 3| 3| 8| 3| 7| 3| 2| 3| 1| 3| 3| |
| 4| 2| 2| 2| 0| 1| 7| 2| 9| 5| 2| 8| 9| 8| 2| 2| 4| 2| 1| 2| 2| 1| 4| 1| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | A + + + A A A + + + + + + A + A + + A + M + A M +| 30 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + A + + + + + +| 46 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + A + + + + + + A + + + A + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + A + + + + + +| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Eosinophilic Focus | X | 4 |
Fibrosis | 2 2 | 3 2.3|
Hematopoietic Cell Proliferation | 1 2 3 1 1 2 1 2 3 2| 23 1.7|
Infiltration Cellular, Lymphocyte | 2 1 2 1 2 2 2 2 2 2| 21 1.8|
Inflammation, Chronic Active | 2 1 2 2 2 2 2 | 16 1.9|
Pigmentation, Hemosiderin | 2 2 2 2 2 1 3 2 2 2 2 2 2 2 2 | 24 1.8|
Bile Duct, Cyst | 4 4 3 | 6 2.8|
Bile Duct, Hyperplasia | 2 2 2 1 2 1 | 11 1.5|
Hepatocyte, Necrosis | 3 2 3 1 2 3 1 2 2| 16 2.3|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 | 11 1.2|
Oval Cell, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 1 2| 36 1.9|
Portal, Hypertrophy | 3 3 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + A + + + + A + + + + + +| 46 |
Infiltration Cellular, Lymphocyte | 2 1 2 2| 13 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + M + M + + + + + + + + + + +| 44 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 27 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Diverticulum | X | 1 |
Inflammation, Chronic Active | | 1 2.0|
Epithelium, Hyperplasia, Squamous | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + A + + + + A + + + + + +| 46 |
Atrophy | 2 1 1 2 2 | 10 1.6|
Ectasia | 1 1 1 2 1 1 1 2 1 1 1 2 1 2 1 1 2| 31 1.3|
Hyperplasia | 2 1| 5 1.6|
Inflammation, Chronic Active | 1 1 1 1 1 1 1| 12 1.0|
Mineralization | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 2| 6| 2| 3| 1| 6| 3| 9| 5| 2| 3| 3| 8| 3| 7| 3| 2| 3| 1| 3| 3| |
| 4| 2| 2| 2| 0| 1| 7| 2| 9| 5| 2| 8| 9| 8| 2| 2| 4| 2| 1| 2| 2| 1| 4| 1| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | 1 3 | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | | 1 3.0|
Atrium, Thrombosis | 3 3 | 6 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 1 1 1 1 1 1 2 1| 17 1.4|
Subcapsular, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 1 1 2 2 2 1 3 2 2 2 2 1 2 2| 49 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 1 1| 7 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + A + + + + + +| 46 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + M M + + M + M M + + + + + +| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + + M + + + + + + +| 44 |
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 46 |
Follicle, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 2 2 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + M + + + + M + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Cyst | 2 2 2 | 7 2.4|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydrometra | 3 2 2 1 2 2 2 3| 15 2.2|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Hyperplasia | 4 3 3 3 3 3 3 3 4 3 3 3 2 2 3 3 3 3 3 3 3 3 2 3| 46 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 2| 6| 2| 3| 1| 6| 3| 9| 5| 2| 3| 3| 8| 3| 7| 3| 2| 3| 1| 3| 3| |
| 4| 2| 2| 2| 0| 1| 7| 2| 9| 5| 2| 8| 9| 8| 2| 2| 4| 2| 1| 2| 2| 1| 4| 1| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myelofibrosis | 1 | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + M M M + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + A + + M + + +| 43 |
Angiectasis | 4 | 1 4.0|
Ectasia | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
Fibrosis | | 1 4.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 2 | 2 2.5|
Lymphoid Follicle, Necrosis | 2 | 4 1.8|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 3 3 4 3 3 4 3 3 4 3 3 3 3 4 3 3 4 4 2 2 3 4 4 3| 45 3.2|
__________________________________________________________________________|____________|
Thymus | + + M M + + + + M + + + M + + + + M + + + + + + +| 40 |
Cyst | 1 1 1| 5 1.2|
Thymocyte, Necrosis | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Infiltration | | |
Cellular, Lymphocyte | 2 1| 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + +| 3 |
Infiltration Cellular, Lymphocyte | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + M + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 3.0|
Bronchiole, Exudate, Organized | | 1 3.0|
Mediastinum, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 2| 6| 2| 3| 1| 6| 3| 9| 5| 2| 3| 3| 8| 3| 7| 3| 2| 3| 1| 3| 3| |
| 4| 2| 2| 2| 0| 1| 7| 2| 9| 5| 2| 8| 9| 8| 2| 2| 4| 2| 1| 2| 2| 1| 4| 1| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 1 1 | 13 1.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 3 2 2 | 11 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1 1 1 1 1 1 1| 29 1.2|
Mineralization | 2 | 2 2.0|
Necrosis | 3 | 1 3.0|
Nephropathy | 1 2 1 1 3 2 | 9 1.6|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 27 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 2| 0| 8| 3| 6| 8| 2| 1| 8| 5| 2| 5| 5| 3| 1| 1| 7| 2| 7| 3| 8| 8| 3|
| 6| 8| 4| 5| 6| 7| 2| 0| 3| 7| 8| 2| 6| 9| 4| 4| 5| 7| 7| 6| 9| 1| 7| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M M M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + A + + A A + A + A + + A + + A + A + A + + A M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + M + + A + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + A + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 1 1 2 2 2 2 2 2 2 2 2 2 2 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 1 1 2 |
Inflammation, Chronic Active | 2 2 2 4 1 |
Inflammation, Suppurative | 4 |
Pigmentation, Hemosiderin | 1 1 2 2 1 1 1 2 2 2 2 2 |
Bile Duct, Cyst | 3 2 |
Bile Duct, Hyperplasia | 2 2 2 2 |
Hepatocyte, Hyperplasia, Adenomatous | |
Hepatocyte, Necrosis | 3 1 2 2 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 2 1 1 1|
Hepatocyte, Centrilobular, Atrophy | |
Oval Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2 2 1 3 2 2|
Portal, Hypertrophy | 2 3 3 3 3 3 3 3|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Suppurative | 4 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 |
__________________________________________________________________________|
Salivary Glands | M + M + + M M M + + M + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + M + + A + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 |
Epithelium, Hyperplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + M + + A + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 2 |
Ectasia | 1 2 1 1 1 1 1 2 2 2 1 1 1 2 2 2 1 2 2 1 1|
Hyperplasia, Atypical | 1 |
Hyperplasia | 2 1 |
Inflammation, Chronic Active | 1 1 1 2 1 |
Mineralization | 2 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 2| 0| 8| 3| 6| 8| 2| 1| 8| 5| 2| 5| 5| 3| 1| 1| 7| 2| 7| 3| 8| 8| 3|
| 6| 8| 4| 5| 6| 7| 2| 0| 3| 7| 8| 2| 6| 9| 4| 4| 5| 7| 7| 6| 9| 1| 7| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + M + + M M M + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 4 4 4 4 4 4 |
Valve, Inflammation, Suppurative | 2 |
Valve, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 2 1 1 1 1 1 1 1 2 1 |
Pigmentation, Hemosiderin | |
Subcapsular, Hyperplasia | 1 1 2 2 2 2 2 2 1 2 1 2 2 1 2 2 2 2 2 2 2 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + M + + M M M M + M + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + M + + M M M + + M + + + + + + + + + + + + M +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | M + M + + M M M + + M + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + M + + +|
__________________________________________________________________________|
Ovary | + + M + + + + + + M A + + + + + M + + + M + + M +|
Cyst | 2 2 |
Thrombosis | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 2 2 |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 4 3 3 3 4 3 4 3 3|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + +|
Inguinal, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 2| 0| 8| 3| 6| 8| 2| 1| 8| 5| 2| 5| 5| 3| 1| 1| 7| 2| 7| 3| 8| 8| 3|
| 6| 8| 4| 5| 6| 7| 2| 0| 3| 7| 8| 2| 6| 9| 4| 4| 5| 7| 7| 6| 9| 1| 7| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mast Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + M M M M + M + + + + + M + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + A + + M + + + + + + M + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +|
Atrophy | |
Lymphoid Follicle, Depletion Cellular| 3 |
Lymphoid Follicle, Necrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation | 4 3 4 3 4 4 4 2 3 4 4 4 3 3 3 3 3 3 2 3 4 2 4 2|
__________________________________________________________________________|
Thymus | + M M + M M M M M + A + M M + + + + + M + + + M +|
Cyst | 1 2 1 |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + A + + M M + M + + + + M + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + A + + + + + + + + + + + + + +|
Subcutaneous Tissue, Infiltration | |
Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | M + + + + M M M + + M + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + M M M + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
Metaplasia, Osseous | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + I I + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 3 2 1 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 2 1 |
__________________________________________________________________________|
Trachea | + + M + + M M M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 2| 0| 8| 3| 6| 8| 2| 1| 8| 5| 2| 5| 5| 3| 1| 1| 7| 2| 7| 3| 8| 8| 3|
| 6| 8| 4| 5| 6| 7| 2| 0| 3| 7| 8| 2| 6| 9| 4| 4| 5| 7| 7| 6| 9| 1| 7| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 4 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 2 1 2 1 1 |
Metaplasia, Osseous | 2 |
Mineralization | 3 |
Nephropathy | 2 1 3 2 |
Cortex, Cyst | |
Glomerulus, Amyloid Deposition | |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 4 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 5| 6| 6| 5| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 7| 3| 4| 6| 6| 7| |
DAY ON TEST | 0| 0| 1| 8| 9| 9| 7| 5| 4| 0| 7| 3| 7| 7| 0| 0| 6| 7| 2| 1| 7| 5| 8| 8| 1| |
| 7| 3| 2| 6| 2| 2| 6| 2| 8| 5| 7| 1| 6| 6| 1| 5| 6| 8| 7| 1| 9| 0| 1| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + M + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Gallbladder | A A A A + A + M + + + + + M M M + + + M A A M A +| 24 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A A + + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M A + + + + + A + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A A A + + + + A + + + A + + + + + + A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A A + + + + + A + + + A + + + + + A + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X X X | 9 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 2 2 1 1| 24 1.6|
Infiltration Cellular, Lymphocyte | 1 2 2 1 1 1 2 1 1 2 1| 19 1.5|
Inflammation, Chronic Active | 1 1 1 1 2 | 10 1.7|
Inflammation, Suppurative | | 1 4.0|
Pigmentation, Hemosiderin | 2 1 2 1 2 2 2| 19 1.6|
Bile Duct, Cyst | 2 | 3 2.3|
Bile Duct, Hyperplasia | 2 2 2 1 1 | 9 1.8|
Hepatocyte, Hyperplasia, Adenomatous | 4 | 1 4.0|
Hepatocyte, Necrosis | 2 2 3 3 2 1 2 2 3 1 2| 17 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 1 | 12 1.6|
Hepatocyte, Centrilobular, Atrophy | 3 | 1 3.0|
Oval Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1 1| 38 1.9|
Portal, Hypertrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 23 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Suppurative | | 1 4.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + M + + + + + + A + + + A + + + + + + + + + +| 46 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + M + + + + + + + + + +| 42 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 2 1 | 18 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + A + + + + + + + + + + + + + +| 46 |
Hyperkeratosis | | 3 2.0|
Epithelium, Hyperplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + A + + + + + + + + + + + + + +| 45 |
Atrophy | 2 2 2 2 | 10 2.0|
Ectasia | 1 1 1 1 1 2 1 1 2 2 2 2 1 2 1 1 2| 38 1.4|
Hyperplasia, Atypical | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 5| 6| 6| 5| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 7| 3| 4| 6| 6| 7| |
DAY ON TEST | 0| 0| 1| 8| 9| 9| 7| 5| 4| 0| 7| 3| 7| 7| 0| 0| 6| 7| 2| 1| 7| 5| 8| 8| 1| |
| 7| 3| 2| 6| 2| 2| 6| 2| 8| 5| 7| 1| 6| 6| 1| 5| 6| 8| 7| 1| 9| 0| 1| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 2 1.5|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 | 14 1.1|
Mineralization | 2 | 3 1.7|
Necrosis | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + M + + + + + + + + + + M + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + M + + + + + + + + + + M + + + + + + + + + +| 44 |
Atrium, Thrombosis | 2 3 4 | 9 3.7|
Valve, Inflammation, Suppurative | | 1 2.0|
Valve, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 3 2 | 14 1.4|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 48 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 3 | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + + + + + + + + + + A + + + + + + + + + +| 47 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + + + + M + M + M + + + + + + M + + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + M + + + + + + + + + + M + + + + + + + + + +| 40 |
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 3 | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + M + + + + + + + + + +| 42 |
Follicular Cell, Hyperplasia | 2 2 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M + + M + + M + + + + + M + + + +| 44 |
__________________________________________________________________________|____________|
Ovary | + + M A + + + + + + + + + + M + + + + + + + + + +| 41 |
Cyst | 2 1| 4 1.8|
Thrombosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Uterus | + + + A + + + + + + + + + + M + + + + + + + + + +| 47 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 5| 6| 6| 5| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 7| 3| 4| 6| 6| 7| |
DAY ON TEST | 0| 0| 1| 8| 9| 9| 7| 5| 4| 0| 7| 3| 7| 7| 0| 0| 6| 7| 2| 1| 7| 5| 8| 8| 1| |
| 7| 3| 2| 6| 2| 2| 6| 2| 8| 5| 7| 1| 6| 6| 1| 5| 6| 8| 7| 1| 9| 0| 1| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | 3 3 1 | 5 2.2|
Hyperplasia, Cystic | 3 | 2 2.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 3 3 2 4 4 2 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4| 50 3.1|
Myelofibrosis | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Inguinal, Infiltration Cellular, | | |
Mast Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + M + + M + + + + + + M M + + + + M + + + M M| 32 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + M + + + + + + M + M + M + M M + + M + + M +| 36 |
__________________________________________________________________________|____________|
Spleen | + + + A + + + + + + + + + + A M + + + + + + + + +| 46 |
Atrophy | 4 | 1 4.0|
Lymphoid Follicle, Depletion Cellular| 4 | 2 3.5|
Lymphoid Follicle, Necrosis | 2 | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 2 3 4 4 3 2 2 4 4 3 4 3 3 3 3 3 3 2 3 3| 44 3.2|
__________________________________________________________________________|____________|
Thymus | + + + M + M M + + + + + + + M + + + + + M + + + +| 33 |
Cyst | 1 2 1 1 | 7 1.3|
Ectopic Parathyroid Gland | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + A + M + + + + M M + + + + + + + M + + M + +| 37 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcutaneous Tissue, Infiltration | | |
Cellular, Lymphocyte | | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 3 |
Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | M + + M + + + + + + + + + + M + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + M + + + + + + + + + + M + + + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 5| 6| 6| 5| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 7| 3| 4| 6| 6| 7| |
DAY ON TEST | 0| 0| 1| 8| 9| 9| 7| 5| 4| 0| 7| 3| 7| 7| 0| 0| 6| 7| 2| 1| 7| 5| 8| 8| 1| |
| 7| 3| 2| 6| 2| 2| 6| 2| 8| 5| 7| 1| 6| 6| 1| 5| 6| 8| 7| 1| 9| 0| 1| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
Metaplasia, Osseous | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2| 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
Inflammation, Suppurative | 2 1 1 1| 11 1.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 1 1 1 2 2 | 12 1.5|
__________________________________________________________________________|____________|
Trachea | + + + M + + + + + + + + + + M + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 2 | 2 3.0|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 1 1 1 1 1 1| 23 1.2|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 2 | 2 2.5|
Nephropathy | 2 3 1 1 1 1 | 10 1.7|
Cortex, Cyst | 1 2 | 2 1.5|
Glomerulus, Amyloid Deposition | 4 | 1 4.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 2 3.5|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + + + + M + + M + + + + + + +| 46 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 25 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 4| 1| 2| 2| 7| 2| 1| 0| 1| 4| 2| 0| 1| 1| 2| 3| 1| 0| 0| 1| 2| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X X X X |
Eosinophilic Focus | X X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X X X X X X |
Pigmentation, Hemosiderin | 1 |
Hepatocyte, Necrosis | 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 3 1 |
__________________________________________________________________________|
Mesentery | + |
Thrombosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia, Squamous | 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
Malformation | X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 4| 1| 2| 2| 7| 2| 1| 0| 1| 4| 2| 0| 1| 1| 2| 3| 1| 0| 0| 1| 2| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Subcapsular, Hyperplasia | 2 1 2 1 2 3 2 1 1 3 2 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 2 3 3 2 2 2 3 3 3 2 2 2 3 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Cyst | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 3 3 |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Lymph Node | +|
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Necrosis | |
Renal, Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 4| 1| 2| 2| 7| 2| 1| 0| 1| 4| 2| 0| 1| 1| 2| 3| 1| 0| 0| 1| 2| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | |
Lymphoid Follicle, Necrosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 1 2 |
__________________________________________________________________________|
Thymus | M M M + + M + + M + + + + + + + + + + + I M M + +|
Cyst | 1 1 2 2 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M + M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 2 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 2|
Polyp, Inflammatory | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 4| 1| 2| 2| 7| 2| 1| 0| 1| 4| 2| 0| 1| 1| 2| 3| 1| 0| 0| 1| 2| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 |
Inflammation, Suppurative | |
Metaplasia, Osseous | 2 |
Nephropathy | 1 1 2 2 1 1 1 2 1 1 2 1 1 1 2 1 2 1 2 1 1 1 1 2|
Cortex, Cyst | 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 7| 2| |
| 0| 1| 0| 2| 1| 0| 1| 0| 3| 0| 1| 2| 0| 2| 1| 0| 0| 2| 0| 2| 0| 0| 2| 7| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + A | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
Peyer's Patch, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X | 5 |
Clear Cell Focus | X X X X X X X | 16 |
Eosinophilic Focus | X X X X X X | 10 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 3 1.3|
Infiltration Cellular, Lymphocyte | 1 1 2 1 2 | 6 1.3|
Inflammation, Chronic Active | 1 1 2 1 1 2 3 2 1 2 | 19 1.3|
Mixed Cell Focus | X | 9 |
Pigmentation, Hemosiderin | 2 3 | 3 2.0|
Hepatocyte, Necrosis | 2 4 1 2 4 | 8 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 1 | 7 1.6|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Acinus, Atrophy | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 31 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Squamous | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Epithelium, Hyperplasia, Squamous | 2 3 | 5 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Ectasia | 1 1 1 1 1 1 | 13 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 7| 2| |
| 0| 1| 0| 2| 1| 0| 1| 0| 3| 0| 1| 2| 0| 2| 1| 0| 0| 2| 0| 2| 0| 0| 2| 7| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + | 23 |
Inflammation, Chronic Active | | 1 3.0|
Malformation | X X X X X X X X | 22 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Degeneration, Fatty | 1 | 1 1.0|
Subcapsular, Hyperplasia | 1 2 1 2 1 3 1 2 1 1 1 3 1 2 1 1 1 1 1 | 38 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 3 3 3 2 3 3 3 3 3 3 2 3 3 | 32 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + M + + M + + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + I + + M + + + + + | 45 |
Pars Distalis, Cyst | 2 1 1 | 5 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Follicle, Cyst | 2 | 2 2.0|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 3 2 3 3 | 7 2.7|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 | 17 1.1|
Inflammation, Chronic Active | 2 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic Active | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 7| 2| |
| 0| 1| 0| 2| 1| 0| 1| 0| 3| 0| 1| 2| 0| 2| 1| 0| 0| 2| 0| 2| 0| 0| 2| 7| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 3 3 2 2 2 3 3 | 14 2.8|
Infiltration Cellular, Mast Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Necrosis | 2 | 1 2.0|
Renal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M | 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Inflammation, Chronic Active | | 1 2.0|
Necrosis | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 | 1 3.0|
Lymphoid Follicle, Necrosis | 2 2 2 | 3 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 3 3 3 4 2 3 1 | 10 2.4|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + + + M + + M + M | 37 |
Cyst | 1 2 2 1 2 1 | 10 1.5|
Thymocyte, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 7| 2| |
| 0| 1| 0| 2| 1| 0| 1| 0| 3| 0| 1| 2| 0| 2| 1| 0| 0| 2| 0| 2| 0| 0| 2| 7| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 1 | 2 1.5|
Inflammation, Suppurative | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 1 | 7 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 2 2.0|
Bronchiole, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 1 1 1 1 | 9 1.2|
Polyp, Inflammatory | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 4 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 2 | 29 1.1|
Inflammation, Suppurative | 3 | 1 3.0|
Metaplasia, Osseous | | 1 2.0|
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | 43 1.2|
Cortex, Cyst | 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 1 1 | 6 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3|
| 1| 3| 1| 0| 0| 1| 4| 0| 0| 0| 6| 2| 0| 1| 1| 0| 3| 2| 2| 1| 0| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
37 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X X X X X X X X X X X X|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 1 2 2 1 1 |
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Chronic Active | 2 1 1 1 1 1 3 1 2 1|
Mineralization | 1 |
Mixed Cell Focus | X X X X X X X X|
Pigmentation, Hemosiderin | 2 2 |
Tension Lipidosis | X |
Bile Duct, Cyst | 2 |
Bile Duct, Hyperplasia | |
Hepatocyte, Necrosis | 1 1 4 3 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 |
Oval Cell, Hyperplasia | 1 1 1 1 1 2 1 |
Portal, Hypertrophy | 3 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Epithelium, Hyperplasia, Squamous | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Ectasia | 1 1 1 1 1 1 1 1 1 1 1 |
Hyperplasia | 1 |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3|
| 1| 3| 1| 0| 0| 1| 4| 0| 0| 0| 6| 2| 0| 1| 1| 0| 3| 2| 2| 1| 0| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
37 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
Malformation | X X X X X X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Mineralization | |
Artery, Inflammation, Chronic Active | 2 |
Atrium, Thrombosis | 4 |
Valve, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Angiectasis | 3 |
Degeneration, Fatty | |
Hypertrophy | 1|
Subcapsular, Hyperplasia | 2 1 2 1 1 1 2 1 2 2 1 2 2 1 1 1 2 2 1 2 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 2 3 2 2 3 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + M + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + I M + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3|
| 1| 3| 1| 0| 0| 1| 4| 0| 0| 0| 6| 2| 0| 1| 1| 0| 3| 2| 2| 1| 0| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
37 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 2 3 2 3 3 3 3 3 3 3 3 2|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Necrosis | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + M + + + + +|
Angiectasis | |
Ectasia | 3 |
Necrosis | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | |
Necrosis | |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Necrosis | 2 1 |
Red Pulp, Erythrophagocytosis | |
Red Pulp, Hematopoietic Cell | |
Proliferation | 3 3 3 2 2 2 3 3 2 4 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + M + + + + + + + M M M +|
Cyst | 1 1 1 2 1 1 2 2 1 2|
Ectopic Parathyroid Gland | 2 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3|
| 1| 3| 1| 0| 0| 1| 4| 0| 0| 0| 6| 2| 0| 1| 1| 0| 3| 2| 2| 1| 0| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
37 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 1 1 3|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 1 2 2 2 1 1 |
Polyp, Inflammatory | 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1 1 1 1 1 3 1 1 1|
Inflammation, Suppurative | |
Metaplasia, Osseous | 1|
Mineralization | |
Nephropathy | 2 1 1 1 2 2 2 1 1 1 2 2 3 3 2 2 2 2 2 3 1 1 1 2|
Artery, Inflammation, Chronic Active | 2 |
Cortex, Cyst | 2 2 1 1 3 2 2 2 3 2 2 3|
Papilla, Mineralization | 3 |
Papilla, Necrosis | 4 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3| |
| 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A A + + + + A + M + + + + + + + + + M + + + + M +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Clear Cell Focus | X X X | 8 |
Eosinophilic Focus | X X X X X X X X | 20 |
Fibrosis | 3 2 3 | 4 2.5|
Hematopoietic Cell Proliferation | 2 1 1 | 9 1.3|
Infiltration Cellular, Lymphocyte | 1 2 3 | 5 1.6|
Inflammation, Chronic Active | 1 1 1 1 2 1 2 1 1 1 2 | 21 1.3|
Mineralization | 2 3 | 3 2.0|
Mixed Cell Focus | X X X X X| 13 |
Pigmentation, Hemosiderin | 3 3 1 | 5 2.2|
Tension Lipidosis | | 1 |
Bile Duct, Cyst | | 1 2.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
Hepatocyte, Necrosis | 1 1 1 1 2 4 3 3 4 2 | 14 2.2|
Hepatocyte, Vacuolization Cytoplasmic| 1 3 1 2| 7 1.4|
Oval Cell, Hyperplasia | 1 | 8 1.1|
Portal, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 | 4 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Epithelium, Hyperplasia, Squamous | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + A + + + + + + + +| 48 |
Atrophy | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3| |
| 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ectasia | 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 25 1.0|
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1| 11 1.1|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + | 13 |
Inflammation, Chronic Active | | 1 3.0|
Malformation | X X X X X X | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 2.0|
Mineralization | 1 | 1 1.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Atrium, Thrombosis | | 1 4.0|
Valve, Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.5|
Angiectasis | | 1 3.0|
Degeneration, Fatty | 1 | 1 1.0|
Hypertrophy | 2 2 2 2| 5 1.8|
Subcapsular, Hyperplasia | 1 1 2 2 2 1 2 1 2 1 2 2 1 1 2 2 1 2 2 | 42 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 3 3 3 2 3 3 3 3 3 2 3 3 | 26 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + M + + + + + + M| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | 2 1 2| 7 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Follicle, Cyst | 2 1 | 2 1.5|
Follicular Cell, Hyperplasia | 2 1 2 | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3| |
| 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 | 6 3.0|
Infiltration Cellular, Lymphocyte | 1 1 1 2 2 1 2 1 2 2 1| 15 1.4|
Inflammation, Chronic Active | 2 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 | 2 1.5|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 3 3 3 2 2 2 3 | 26 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + M + + + + + M +| 46 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + A + + + + + + + + + + + + + + + + + +| 46 |
Angiectasis | 2 | 1 2.0|
Ectasia | | 1 3.0|
Necrosis | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Lymphoid Follicle, Necrosis | 1 2 2 2 | 6 1.7|
Red Pulp, Erythrophagocytosis | 4 | 1 4.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 2 2 2 3 2 3 2 3 | 20 2.6|
__________________________________________________________________________|____________|
Thymus | + M I + + M M + + + + + + + + + + + I + + + + + +| 40 |
Cyst | 2 1 1 2 1 1 2 2 1 | 19 1.4|
Ectopic Parathyroid Gland | | 1 2.0|
Thymocyte, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3| |
| 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M M M M M M M M M M M + M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 2.0|
Thrombosis | 2 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2 2 3 | 6 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Inflammation, Suppurative | 1 2 1 1 1 1 | 13 1.4|
Polyp, Inflammatory | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.1|
Inflammation, Suppurative | 2 | 1 2.0|
Metaplasia, Osseous | 1 1| 3 1.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 2 2 2 2 1 1 2 1 2 1 2 1 1 1 2 3 1 2 1 3 2| 45 1.7|
Artery, Inflammation, Chronic Active | | 1 2.0|
Cortex, Cyst | 1 2 3 2 3 1 2 2 2 2 2 3 2 1 2| 27 2.0|
Papilla, Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3| |
| 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
37 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Papilla, Necrosis | | 1 4.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | X | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 2| 8| 3| 3| 3| 3| 3| 2| 3| 3| 3|
| 2| 0| 6| 0| 0| 1| 1| 1| 2| 1| 0| 1| 5| 2| 6| 9| 0| 1| 2| 2| 1| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X X X X X X X X X X X|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 2 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 2 1 1 |
Mineralization | 1 |
Mixed Cell Focus | X X X |
Pigmentation, Hemosiderin | 2 2 |
Bile Duct, Cyst | |
Hepatocyte, Necrosis | 1 1 2 2 1 1|
Hepatocyte, Vacuolization Cytoplasmic| 1 |
Hepatocyte, Centrilobular, Atrophy | |
Oval Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 2 1 |
Portal, Hypertrophy | 3 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia, Squamous | 3 |
Epithelium, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 2 2 2 1 1 4 1 1 1 1 1 1 1 1|
Ectasia | 1 1 1 2 2 2 2 2 2 1 1 1 1 1 1 1 1 1 1 2 1|
Hyperplasia, Atypical | 1 |
Hyperplasia | 1 2 3 2 2 2 2 1 1 |
Inflammation, Chronic Active | 1 1 2 2 1 1 1 1 1 2 1 1 2 |
Mineralization | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 2| 8| 3| 3| 3| 3| 3| 2| 3| 3| 3|
| 2| 0| 6| 0| 0| 1| 1| 1| 2| 1| 0| 1| 5| 2| 6| 9| 0| 1| 2| 2| 1| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + |
Malformation | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hypertrophy | 2 |
Pigmentation, Hemosiderin | |
Subcapsular, Hyperplasia | 2 1 2 1 1 1 1 2 2 2 2 2 2 1 2 2 1 1 1 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 2 3 3 3 3 3 2 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + I I + + + M + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 2 |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
Infiltration Cellular, Lymphocyte | 2 2 1 1 2 1 1|
Inflammation, Chronic Active | 2 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 3 3 3 3 2 3 3 3 3 3 4 3 3 3 2 3 2 2|
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 2| 8| 3| 3| 3| 3| 3| 2| 3| 3| 3|
| 2| 0| 6| 0| 0| 1| 1| 1| 2| 1| 0| 1| 5| 2| 6| 9| 0| 1| 2| 2| 1| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Ectasia | 3 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | |
Lymphoid Follicle, Necrosis | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 1 3 2 1 2 2 3 2 2 2 4 2 2 3 3 2|
__________________________________________________________________________|
Thymus | M M + + + + M + + + + + + + + + M + + M + + + + +|
Cyst | 2 2 3 2 1 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 2| 8| 3| 3| 3| 3| 3| 2| 3| 3| 3|
| 2| 0| 6| 0| 0| 1| 1| 1| 2| 1| 0| 1| 5| 2| 6| 9| 0| 1| 2| 2| 1| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 |
Mineralization | 1 |
Nephropathy | 1 1 2 1 1 2 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
| 1| 2| 2| 0| 2| 0| 2| 0| 1| 2| 1| 0| 4| 0| 0| 1| 7| 1| 0| 0| 0| 2| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + M + + + A + + + A + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X X| 2 |
Eosinophilic Focus | X X X X X X X X| 25 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 1 2 1 1 1 | 7 1.3|
Infiltration Cellular, Lymphocyte | 1 2 1| 12 1.3|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 2 1 2 2 1 2 | 28 1.3|
Mineralization | | 1 1.0|
Mixed Cell Focus | X X X X X X| 9 |
Pigmentation, Hemosiderin | 2 3 2 1 | 6 2.0|
Bile Duct, Cyst | 2 | 1 2.0|
Hepatocyte, Necrosis | 4 2 | 8 1.8|
Hepatocyte, Vacuolization Cytoplasmic| 1| 2 1.0|
Hepatocyte, Centrilobular, Atrophy | 3 | 1 3.0|
Oval Cell, Hyperplasia | 2 1 1 2 1 2 2 1 1 1 1 1 1| 27 1.2|
Portal, Hypertrophy | 2 3 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 1 2 | 4 1.8|
Inflammation, Chronic Active | 2 2 | 3 2.0|
Epithelium, Hyperplasia, Squamous | 3 1 | 3 2.3|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Atrophy | 2 2 2 1 2 1 2 1 2 2 2 2 1 1 1 1 1| 35 1.5|
Ectasia | 1 2 1 1 2 1 1 2 1 2 2 1 1 2 2 1 1 1 1| 40 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
| 1| 2| 2| 0| 2| 0| 2| 0| 1| 2| 1| 0| 4| 0| 0| 1| 7| 1| 0| 0| 0| 2| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Atypical | | 1 1.0|
Hyperplasia | 2 1 2 1 1 3 | 15 1.7|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 1 1 2| 25 1.2|
Mineralization | 1 | 1 1.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 4 |
Malformation | X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hypertrophy | 1 2 | 3 1.7|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 2 2 2 1 1 1 2 1 1 1 1 1 1 1| 44 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 | 18 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + M + M + + + + + + + + M + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + I + +| 44 |
Pars Distalis, Cyst | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | | 2 2.0|
Follicular Cell, Hyperplasia | 1 2 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 2 2 | 10 2.8|
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 1 1| 14 1.5|
Inflammation, Chronic Active | 4 3 2 2 4 | 8 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
| 1| 2| 2| 0| 2| 0| 2| 0| 1| 2| 1| 0| 4| 0| 0| 1| 7| 1| 0| 0| 0| 2| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hyperplasia | 3 3 2 3 3 3 3 3 3 3 3 3 2 2 | 33 2.8|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Congestion | | 1 3.0|
Ectasia | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 3.5|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 | 1 3.0|
Lymphoid Follicle, Necrosis | | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 2 2 4 4 2 2 2 3 3 | 25 2.4|
__________________________________________________________________________|____________|
Thymus | + + M + M M + M + M + + + + + + + M + I + + + + +| 38 |
Cyst | 2 2 2 1 2 2 1 2 1| 16 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
| 1| 2| 2| 0| 2| 0| 2| 0| 1| 2| 1| 0| 4| 0| 0| 1| 7| 1| 0| 0| 0| 2| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 3 1 2 | 5 1.8|
Alveolus, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 2 | 11 1.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 3 2 2 2 1 2 | 8 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 1 1 3 1| 27 1.1|
Mineralization | 2 1 | 3 1.3|
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 1 1| 45 1.2|
Cortex, Cyst | 2 2 3 2 2 2 2 1 2 2 2 2 2 | 20 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 9 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 8| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 6| 3|
| 1| 1| 0| 1| 9| 9| 1| 1| 0| 2| 2| 8| 4| 1| 2| 2| 1| 2| 9| 0| 2| 0| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + A + + + M M + + M + + + + + + M + M + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Peyer's Patch, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X |
Hematopoietic Cell Proliferation | 1 2 1 3 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 |
Inflammation, Chronic Active | 2 2 1 1 2 1 2 1 2 2 1 1 1|
Mixed Cell Focus | X X X X|
Pigmentation, Hemosiderin | 1 1 1|
Bile Duct, Hyperplasia | |
Hepatocyte, Necrosis | 1 1 4 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 2 1 2 2 3 3|
Hepatocyte, Centrilobular, Necrosis | 3 |
Oval Cell, Hyperplasia | 2 2 3 1 2 1 2 1 2 2 3 2 1 1 1 1 1 1 3 1 2 1|
Portal, Hypertrophy | 3 3 3 2 1 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 3 2 3 3 2 2 2 3 2 3 3 3 2 3 2 3 3 3 2 2|
Ectasia | 2 1 2 1 2 1 1 1 2 2 1 2 3 2 2 2 1 1 1 2 2 2 2 2|
Hyperplasia, Atypical | 1 |
Hyperplasia | 1 1 2 1 1 4 1 1 1 2 1 1 |
Inflammation, Chronic Active | 1 1 1 2 1 1 2 1 2 1 1 2 1 1 1 1 1 1|
Inflammation, Suppurative | |
Mineralization | 2 1|
Neuroendocrine Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 8| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 6| 3|
| 1| 1| 0| 1| 9| 9| 1| 1| 0| 2| 2| 8| 4| 1| 2| 2| 1| 2| 9| 0| 2| 0| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + |
Inflammation, Chronic Active | |
Malformation | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Mineralization | 1 |
Artery, Inflammation, Chronic Active | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hypertrophy | 2 |
Subcapsular, Hyperplasia | 3 1 1 1 1 2 2 1 1 1 2 1 2 2 1 1 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 2 3 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 2 2 3 1 2 1 |
Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 8| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 6| 3|
| 1| 1| 0| 1| 9| 9| 1| 1| 0| 2| 2| 8| 4| 1| 2| 2| 1| 2| 9| 0| 2| 0| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 3 3 3 3 3 3 3 3 3 3 3 2 4 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M M + + + + + + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 |
Lymphoid Follicle, Necrosis | 2 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 3 2 4 4 3 4 2 2 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + I + M M + M + + + + + + + M + + + + +|
Cyst | 1 2 1 2 |
Ectopic Parathyroid Gland | 2 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | |
Nerve, Demyelination | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Mediastinum, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 8| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 6| 3|
| 1| 1| 0| 1| 9| 9| 1| 1| 0| 2| 2| 8| 4| 1| 2| 2| 1| 2| 9| 0| 2| 0| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Necrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 2 1 1 1|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | |
Mineralization | 2 1 |
Necrosis | 2 |
Nephropathy | 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 2 1 1 1 2 2|
Cortex, Cyst | 2 1 3 1 2 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4| |
| 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + + + + + + + + M + + + + M +| 39 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Peyer's Patch, Inflammation, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Basophilic Focus | X X | 3 |
Clear Cell Focus | X X X X X | 6 |
Eosinophilic Focus | X X X X X X X X X X X X X | 19 |
Hematopoietic Cell Proliferation | 3 1 1 1| 9 1.6|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 2 1 | 10 1.2|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 | 28 1.3|
Mixed Cell Focus | X X X | 7 |
Pigmentation, Hemosiderin | 2 2 | 5 1.4|
Bile Duct, Hyperplasia | 3 | 1 3.0|
Hepatocyte, Necrosis | 2 2 2 3 1 | 10 1.9|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 | 13 1.5|
Hepatocyte, Centrilobular, Necrosis | 3 | 2 3.0|
Oval Cell, Hyperplasia | 2 1 1 1 2 1 2 1 1 2 1 1 1 1 1 1 1 2 1 2 1 2 2 2| 46 1.5|
Portal, Hypertrophy | 4 3 1 1 3 3 3 3 3 3 3 3 3 3 3 3 1 3 2 3 3 3 2 3 4| 46 2.8|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 | 4 1.3|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Squamous | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 3 2 3 3 2 2 3 2 2 3 2 2 3 3 3 2 3 3 3 2| 45 2.6|
Ectasia | 1 2 2 2 2 2 1 2 2 3 2 1 2 1 2 1 1 1 1 2 2 1 2 2 1| 49 1.7|
Hyperplasia, Atypical | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4| |
| 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 1 1 3 4 1 2 2 4 | 20 1.8|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 2 1 1 2 1 1 2 2 | 33 1.3|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | 2 2 | 4 1.8|
Neuroendocrine Cell, Hyperplasia | 4 3 1 4 | 4 3.0|
__________________________________________________________________________|____________|
Tooth | + + | 5 |
Inflammation, Chronic Active | 3 | 1 3.0|
Malformation | X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 | 2 1.5|
Mineralization | | 1 1.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Atrium, Thrombosis | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Hypertrophy | 2 | 2 2.0|
Subcapsular, Hyperplasia | 2 3 1 1 1 2 1 2 1 3 2 1 1 1 2 2 2 1 1 2 1 1 | 43 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 3 2 | 17 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + M M M + + M + M M + M M + M M M M + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + M + + + + + + + + I + + + +| 45 |
Pars Distalis, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 3 1.3|
Follicle, Cyst | 2 2 | 2 2.0|
Follicular Cell, Hyperplasia | 1 2 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4| |
| 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 | 5 2.8|
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 1 1 | 18 1.4|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 3 3 3 1 3 2 3 3 1 3 3 3 3 3 3 3| 35 2.8|
__________________________________________________________________________|____________|
Lymph Node | + +| 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + M| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 3 | 3 2.7|
Lymphoid Follicle, Necrosis | | 2 2.5|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 3 2 3 2 2 2 3 2 | 19 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Cyst | 2 2 1 1 1 2 1 1 | 12 1.4|
Ectopic Parathyroid Gland | | 1 2.0|
Thymocyte, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M + M M M M M M M M M M M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4| |
| 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Hemorrhage | 3 | 1 3.0|
Nerve, Demyelination | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 5 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 1.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 2.0|
Mediastinum, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 2 1 1 1 | 10 1.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | 40 1.1|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 1 1 | 4 1.3|
Necrosis | | 1 2.0|
Nephropathy | 1 2 2 2 1 2 2 2 1 2 2 1 2 1 2 2 2 2 2 1 2 2 1 3| 48 1.5|
Cortex, Cyst | 2 3 3 2 2 2 2 1 | 14 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 10:23:30
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4| |
| 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 | 14 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
------------------------------------------------------------
---------- END OF REPORT ----------
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