TDMS Study 05187-09 Pathology Tables
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:39:26 27 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 93-15-2 Lock Date: 09/17/96 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 08/09/94 - 08/10/94 Treatment Groups: Include 002 0 MG/KG Include 010 300 MG/KG Include 001 0 MG/KG Include 009 300 MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:39:26 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 300 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 Scheduled Sacrifice 5 5 Early Deaths Survivors Animals Examined Microscopically 5 5 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (5) (5) Basophilic Focus 2 (40%) Clear Cell Focus 2 (40%) Hepatodiaphragmatic Nodule 1 (20%) 2 (40%) Mixed Cell Focus 3 (60%) Hepatocyte, Hypertrophy 5 (100%) Oval Cell, Hyperplasia 5 (100%) Pancreas (5) (5) Acinus, Atrophy 1 (20%) 1 (20%) Salivary Glands (5) (5) Submandibular Gland, Cytoplasmic Alteration 5 (100%) Stomach, Glandular (5) (5) Atrophy 5 (100%) Neuroendocrine Cell, Hyperplasia 1 (20%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Islets, Pancreatic (5) (5) Hyperplasia 1 (20%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:39:26 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 300 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (5) (5) Cyst 1 (20%) Uterus (5) (5) Hyperplasia, Cystic 1 (20%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (5) (5) Hyperplasia 4 (80%) Lymph Node (1) Erythrophagocytosis 1 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (5) (5) Inflammation, Granulomatous 1 (20%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:39:26 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 300 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 Scheduled Sacrifice 5 5 Early Deaths Survivors Animals Examined Microscopically 5 5 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Rectum (5) (5) Parasite Metazoan 1 (20%) Liver (5) (5) Basophilic Focus 3 (60%) Eosinophilic Focus 3 (60%) Hepatodiaphragmatic Nodule 1 (20%) Mixed Cell Focus 5 (100%) Hepatocyte, Hypertrophy 5 (100%) Oval Cell, Hyperplasia 5 (100%) Pancreas (5) (5) Acinus, Atrophy 1 (20%) 2 (40%) Duct, Hyperplasia 1 (20%) Salivary Glands (5) (5) Submandibular Gland, Cytoplasmic Alteration 5 (100%) Stomach, Glandular (5) (5) Atrophy 5 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (5) (5) Myocardium, Degeneration 3 (60%) 2 (40%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Islets, Pancreatic (5) (5) Hyperplasia 1 (20%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:39:26 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 300 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (5) (5) Inflammation, Chronic 1 (20%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (5) (5) Hyperplasia 1 (20%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (5) (5) Nephropathy 4 (80%) 5 (100%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------