TDMS Study 05187-09 Pathology Tables
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:39:26
27 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 93-15-2
Lock Date: 09/17/96
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 08/09/94 - 08/10/94
Treatment Groups: Include 002 0 MG/KG
Include 010 300 MG/KG
Include 001 0 MG/KG
Include 009 300 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:39:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (5) (5)
Basophilic Focus 2 (40%)
Clear Cell Focus 2 (40%)
Hepatodiaphragmatic Nodule 1 (20%) 2 (40%)
Mixed Cell Focus 3 (60%)
Hepatocyte, Hypertrophy 5 (100%)
Oval Cell, Hyperplasia 5 (100%)
Pancreas (5) (5)
Acinus, Atrophy 1 (20%) 1 (20%)
Salivary Glands (5) (5)
Submandibular Gland, Cytoplasmic Alteration 5 (100%)
Stomach, Glandular (5) (5)
Atrophy 5 (100%)
Neuroendocrine Cell, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Islets, Pancreatic (5) (5)
Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:39:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (5) (5)
Cyst 1 (20%)
Uterus (5) (5)
Hyperplasia, Cystic 1 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (5) (5)
Hyperplasia 4 (80%)
Lymph Node (1)
Erythrophagocytosis 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (5) (5)
Inflammation, Granulomatous 1 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:39:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (5) (5)
Parasite Metazoan 1 (20%)
Liver (5) (5)
Basophilic Focus 3 (60%)
Eosinophilic Focus 3 (60%)
Hepatodiaphragmatic Nodule 1 (20%)
Mixed Cell Focus 5 (100%)
Hepatocyte, Hypertrophy 5 (100%)
Oval Cell, Hyperplasia 5 (100%)
Pancreas (5) (5)
Acinus, Atrophy 1 (20%) 2 (40%)
Duct, Hyperplasia 1 (20%)
Salivary Glands (5) (5)
Submandibular Gland, Cytoplasmic Alteration 5 (100%)
Stomach, Glandular (5) (5)
Atrophy 5 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (5) (5)
Myocardium, Degeneration 3 (60%) 2 (40%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Islets, Pancreatic (5) (5)
Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:39:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (5) (5)
Inflammation, Chronic 1 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (5) (5)
Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5)
Nephropathy 4 (80%) 5 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------