TDMS Study 05187-09 Pathology Tables
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:46:24
52 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 93-15-2
Lock Date: 09/17/96
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 02/02/95 - 02/03/95
Treatment Groups: Include 002 0 MG/KG
Include 010 300 MG/KG
Include 001 0 MG/KG
Include 009 300 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:46:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (5) (5)
Parasite Metazoan 1 (20%)
Liver (5) (5)
Basophilic Focus 5 (100%) 3 (60%)
Clear Cell Focus 1 (20%) 2 (40%)
Eosinophilic Focus 3 (60%)
Hepatodiaphragmatic Nodule 2 (40%)
Mixed Cell Focus 5 (100%)
Bile Duct, Cyst 1 (20%)
Hepatocyte, Hypertrophy 5 (100%)
Oval Cell, Hyperplasia 5 (100%)
Salivary Glands (5) (5)
Submandibular Gland, Cytoplasmic Alteration 5 (100%)
Stomach, Glandular (5) (5)
Atrophy 5 (100%)
Neuroendocrine Cell, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (5) (5)
Myocardium, Degeneration 2 (40%) 1 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (5) (5)
Cyst 1 (20%)
Pars Distalis, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:46:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (5) (5)
Cyst 1 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (5) (5)
Dilatation 3 (60%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:46:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5)
Nephropathy 4 (80%) 2 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:46:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 5 5
Early Deaths
Survivors
Animals Examined Microscopically 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (5) (5)
Parasite Metazoan 1 (20%) 1 (20%)
Liver (5) (5)
Basophilic Focus 1 (20%) 3 (60%)
Clear Cell Focus 1 (20%) 1 (20%)
Degeneration, Cystic, Focal 5 (100%)
Eosinophilic Focus 5 (100%)
Hepatodiaphragmatic Nodule 1 (20%)
Mixed Cell Focus 5 (100%)
Bile Duct, Hyperplasia 1 (20%)
Bile Duct, Hyperplasia, Atypical, Focal 1 (20%)
Hepatocyte, Hypertrophy 5 (100%)
Oval Cell, Hyperplasia 5 (100%)
Salivary Glands (5) (5)
Submandibular Gland, Cytoplasmic Alteration 5 (100%)
Stomach, Glandular (5) (5)
Atrophy 5 (100%)
Neuroendocrine Cell, Hyperplasia 2 (40%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (5) (5)
Myocardium, Degeneration 4 (80%) 3 (60%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Islets, Pancreatic (5) (5)
Hyperplasia 2 (40%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:46:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (5) (5)
Interstitial Cell, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (5) (5)
Hyperplasia 1 (20%) 5 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (5) (5)
Inflammation, Granulomatous 1 (20%)
Alveolar Epithelium, Hypertrophy, Focal 1 (20%)
Nose (5) (5)
Inflammation, Suppurative 1 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05187-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:46:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 300
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5)
Nephropathy 5 (100%) 5 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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