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TDMS Study 05187-09 Pathology Tables

NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 08:46:24
                                                          52 WEEK SSAC
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  93-15-2
       Lock Date:  09/17/96
       Cage Range:  All
       Reasons For Removal:    25017 Scheduled Sacrifice
       Removal Date Range:     02/02/95 - 02/03/95
       Treatment Groups:       Include 002    0 MG/KG
                               Include 010    300     MG/KG
                               Include 001    0 MG/KG
                               Include 009    300     MG/KG
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60                                                               
  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Colon                             (5)          (5)                                                              
      Parasite Metazoan                                1 (20%)                                                                      
   Liver                                              (5)          (5)                                                              
      Basophilic Focus                                 5 (100%)     3 (60%)                                                         
      Clear Cell Focus                                 1 (20%)      2 (40%)                                                         
      Eosinophilic Focus                                            3 (60%)                                                         
      Hepatodiaphragmatic Nodule                       2 (40%)                                                                      
      Mixed Cell Focus                                              5 (100%)                                                        
      Bile Duct, Cyst                                               1 (20%)                                                         
      Hepatocyte, Hypertrophy                                       5 (100%)                                                        
      Oval Cell, Hyperplasia                                        5 (100%)                                                        
   Salivary Glands                                    (5)          (5)                                                              
      Submandibular Gland, Cytoplasmic Alteration                   5 (100%)                                                        
   Stomach, Glandular                                 (5)          (5)                                                              
      Atrophy                                                       5 (100%)                                                        
      Neuroendocrine Cell, Hyperplasia                              1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (5)          (5)                                                              
      Myocardium, Degeneration                         2 (40%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Pituitary Gland                                    (5)          (5)                                                              
      Cyst                                                          1 (20%)                                                         
      Pars Distalis, Hyperplasia                                    1 (20%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (5)          (5)                                                              
      Cyst                                                          1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (5)          (5)                                                              
      Dilatation                                       3 (60%)                                                                      
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (5)          (5)                                                              
      Nephropathy                                      4 (80%)      2 (40%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60                                                               
  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Rectum                            (5)          (5)                                                              
      Parasite Metazoan                                1 (20%)      1 (20%)                                                         
   Liver                                              (5)          (5)                                                              
      Basophilic Focus                                 1 (20%)      3 (60%)                                                         
      Clear Cell Focus                                 1 (20%)      1 (20%)                                                         
      Degeneration, Cystic, Focal                                   5 (100%)                                                        
      Eosinophilic Focus                                            5 (100%)                                                        
      Hepatodiaphragmatic Nodule                                    1 (20%)                                                         
      Mixed Cell Focus                                              5 (100%)                                                        
      Bile Duct, Hyperplasia                                        1 (20%)                                                         
      Bile Duct, Hyperplasia, Atypical, Focal                       1 (20%)                                                         
      Hepatocyte, Hypertrophy                                       5 (100%)                                                        
      Oval Cell, Hyperplasia                                        5 (100%)                                                        
   Salivary Glands                                    (5)          (5)                                                              
      Submandibular Gland, Cytoplasmic Alteration                   5 (100%)                                                        
   Stomach, Glandular                                 (5)          (5)                                                              
      Atrophy                                                       5 (100%)                                                        
      Neuroendocrine Cell, Hyperplasia                              2 (40%)                                                         
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (5)          (5)                                                              
      Myocardium, Degeneration                         4 (80%)      3 (60%)                                                         
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Islets, Pancreatic                                 (5)          (5)                                                              
      Hyperplasia                                      2 (40%)                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Testes                                             (5)          (5)                                                              
      Interstitial Cell, Hyperplasia                   1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (5)          (5)                                                              
      Hyperplasia                                      1 (20%)      5 (100%)                                                        
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (5)          (5)                                                              
      Inflammation, Granulomatous                                   1 (20%)                                                         
      Alveolar Epithelium, Hypertrophy, Focal          1 (20%)                                                                      
   Nose                                               (5)          (5)                                                              
      Inflammation, Suppurative                                     1 (20%)                                                         
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Eye                                                (1)                                                                           
      Cataract                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (5)          (5)                                                              
      Nephropathy                                      5 (100%)     5 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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