TDMS Study 05187-09 Pathology Tables
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
52 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 93-15-2
Lock Date: 09/17/96
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 02/02/95 - 02/03/95
Treatment Groups: Include 002 0 MG/KG
Include 010 300 MG/KG
Include 001 0 MG/KG
Include 009 300 MG/KG
Page 1
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 3| 3| | A |
0 MG/KG | 7| 8| 9| 0| 2| | L |
| 7| 7| 3| 4| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Basophilic Focus | X X X X X | 5 |
Clear Cell Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Myocardium, Degeneration | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 3| 3| | A |
0 MG/KG | 7| 8| 9| 0| 2| | L |
| 7| 7| 3| 4| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
Dilatation | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Nephropathy | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| | A |
300 | 0| 0| 2| 2| 3| | L |
MG/KG | 0| 7| 6| 8| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Basophilic Focus | X X X | 3 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | X X X | 3 |
Mixed Cell Focus | X X X X X | 5 |
Bile Duct, Cyst | 3 | 1 3.0|
Hepatocyte, Hypertrophy | 3 3 3 3 3 | 5 3.0|
Oval Cell, Hyperplasia | 2 2 2 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
Submandibular Gland, Cytoplasmic | | |
Alteration | 2 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
Atrophy | 3 3 3 3 3 | 5 3.0|
Neuroendocrine Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Myocardium, Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| | A |
300 | 0| 0| 2| 2| 3| | L |
MG/KG | 0| 7| 6| 8| 7| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + | 4 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Nephropathy | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 2| 3| 4| 5| 5| | L |
| 3| 0| 5| 2| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Myocardium, Degeneration | 1 2 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 2| 3| 4| 5| 5| | L |
| 3| 0| 5| 2| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Alveolar Epithelium, Hypertrophy, | | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Nephropathy | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
300 | 2| 4| 4| 5| 5| | L |
MG/KG | 7| 0| 7| 1| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Basophilic Focus | X X X | 3 |
Clear Cell Focus | X | 1 |
Degeneration, Cystic, Focal | 1 1 1 1 1 | 5 1.0|
Eosinophilic Focus | X X X X X | 5 |
Hepatodiaphragmatic Nodule | X | 1 |
Mixed Cell Focus | X X X X X | 5 |
Bile Duct, Hyperplasia, Atypical, | | |
Focal | 4 | 1 4.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 3 3 3 3 3 | 5 3.0|
Oval Cell, Hyperplasia | 1 2 1 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
Submandibular Gland, Cytoplasmic | | |
Alteration | 2 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
Atrophy | 1 2 2 2 3 | 5 2.0|
Neuroendocrine Cell, Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Myocardium, Degeneration | 2 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
300 | 2| 4| 4| 5| 5| | L |
MG/KG | 7| 0| 7| 1| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
Hyperplasia | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + M | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98
Route: GAVAGE Time: 08:53:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
300 | 2| 4| 4| 5| 5| | L |
MG/KG | 7| 0| 7| 1| 4| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Nephropathy | 2 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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