TDMS Study 05187-09 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus METHYLEUGENOL DATE: 07/20/98
EXPERIMENT: 05187 TEST: 09 TIME: 09:16:17
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25337 ROUTE: GAVAGE NTP C#: 60991B
PATHOLOGIST: MISSING CAS: 93-15-2
------------------------------------------------------------------------------------------------------------------------------------
STOP STUDY
REASONS FOR REMOVAL: 25022 Accidently Killed
25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 MG/KG
INCLUDE 002 0 MG/KG
INCLUDE 009 300 MG/KG
INCLUDE 010 300 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus METHYLEUGENOL DATE: 07/20/98
EXPERIMENT: 05187 TEST: 09 TIME: 09:16:17
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25337 ROUTE: GAVAGE NTP C#: 60991B
PATHOLOGIST: MISSING CAS: 93-15-2
METHYLEUGENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 344 521 529 553 564 588 603 610 610 614 |
| 617 626 639 642 652 661 662 668 704 704 |
| 707 707 712 714 715 718 721 722 722 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 49 CENSORED DEATHS 1 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 177 219 299 380 437 495 498 502 506 513 |
| 517 521 526 528 528 533 533 537 540 548 |
| 553 556 556 557 570 572 572 582 589 589 |
| 589 591 592 592 597 601 604 604 608 619 |
| 627 631 633 634 638 653 674 680 684 |
| CENSORED DEATHS |
| 18 |
| |
==================================================================================
METHYLEUGENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 98.0 98.0 94.0 86.0 66.0 40.0 |
| | |
| | |
|300 | 100.0 98.0 95.9 93.9 91.8 89.8 61.2 22.4 6.1 0.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 300 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 40.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 642.6 548.7 |
|NATURAL DEATHS (C) | (15.3) (14.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 677.6 538.0 |
|(STANDARD ERROR) | (11.0) (17.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
METHYLEUGENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 241 407 448 459 459 549 555 569 597 598 |
| 598 609 616 619 641 641 641 644 653 679 |
| 683 698 700 703 711 717 719 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 183 281 288 331 459 477 519 528 560 571 |
| 609 609 611 620 620 637 641 641 642 653 |
| 659 660 665 679 679 694 703 703 703 709 |
| 711 724 724 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
METHYLEUGENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 98.0 98.0 96.0 90.0 90.0 78.0 62.0 44.0 |
| | |
| | |
|300 | 100.0 100.0 98.0 92.0 92.0 88.0 84.0 80.0 54.0 32.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 300 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.0% 32.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.343 P=0.343 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 602.8 594.6 |
|NATURAL DEATHS (C) | (21.3) (23.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 658.8 637.9 |
|(STANDARD ERROR) | (14.9) (18.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
METHYLEUGENOL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
300 MG/KG = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 2 1 1
| 2 2 2 11 1
| 2 2 1 1
90 + 2 2 1 1
| 22 1 1
| 11
| 222
80 + 11
| 2 2 11
| 22 1 1
| 1 1
P 70 + 22 1 1
E |
R | 11 1
C | 22
E 60 + 22
N | 22
T | 11
| 11
S 50 + 2 2
U |
R | 2 2 11
V | 2 2 1 1
I 40 + 1
V |
A |
L |
30 + 22
| 22
|
|
20 + 2 2
| 222
|
|
10 + 22
| 2 2
| 2 22
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
METHYLEUGENOL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
300 MG/KG = 2
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 1 2 1
| 22 2 1 1 1
| 2 2
90 + 1 2 1
| 2 2 11
P | 22 1 1 1
E | 2 2
R 80 + 2 2
C | 11
E | 111
N | 1 1
T 70 + 2 2
| 22
S | 1 1
U | 2 1 1
R 60 + 2 2 11
V | 1 1
I | 2 2 11
V | 11
A 50 + 2 2 11
L | 22
| 11 1
| 22
40 +
| 2 2
|
| 2 2
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.