TDMS Study 05188-06 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
SODIUM XYLENESULFONATE
NTP Experiment-Test: 05188-06 Report: PEIRPT09
Study Type: CHRONIC Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1300-72-7
Lock Date: 07/28/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 9| 4| 4| 4| 2| 8| 5| 4| 4| 4| 7| 7| 4| 4| 4| 4| 2| 4| 4| 4| 4|
| 1| 2| 2| 1| 5| 0| 2| 0| 6| 0| 9| 2| 2| 0| 0| 9| 2| 2| 2| 2| 1| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | X X X X X X X X X |
Hematopoietic Cell Proliferation | 2 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X |
Necrosis | 1 |
Pigmentation, Hemosiderin | |
Bile Duct, Cyst | 1 |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 |
Cytoplasmic Alteration | 1 |
Inflammation | |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Capsule, Hyperplasia, Adenomatous | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 9| 4| 4| 4| 2| 8| 5| 4| 4| 4| 7| 7| 4| 4| 4| 4| 2| 4| 4| 4| 4|
| 1| 2| 2| 1| 5| 0| 2| 0| 6| 0| 9| 2| 2| 0| 0| 9| 2| 2| 2| 2| 1| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M M + + + M + + M + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 3 1 1 4 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 3 1 1 2 1 1 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 4 1 2|
Hemorrhage | 4 |
Inflammation, Chronic Active | 4 |
Metaplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 2 2 2 2 2 3 4|
Pigmentation, Hemosiderin | |
Lymphatic, Angiectasis | 3 |
Lymphatic, Cyst | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 3 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 4 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + M M + M M + + + + + + + M + + +|
Atrophy | 3 2 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 9| 4| 4| 4| 2| 8| 5| 4| 4| 4| 7| 7| 4| 4| 4| 4| 2| 4| 4| 4| 4|
| 1| 2| 2| 1| 5| 0| 2| 0| 6| 0| 9| 2| 2| 0| 0| 9| 2| 2| 2| 2| 1| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Exudate | |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 |
Skin, Site of Application, | |
Inflammation, Chronic | 1 |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neuron, Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation | 1 |
__________________________________________________________________________|
Harderian Gland | + + + + |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 9| 4| 4| 4| 2| 8| 5| 4| 4| 4| 7| 7| 4| 4| 4| 4| 2| 4| 4| 4| 4|
| 1| 2| 2| 1| 5| 0| 2| 0| 6| 0| 9| 2| 2| 0| 0| 9| 2| 2| 2| 2| 1| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 2 |
Nephropathy | 1 1 1 2 1 2 1 1 2 |
Pigmentation | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 2| 4| 4| 4| 2| 4| 5| 4| 4| 3| 4| 5| 4| 4| 9| 9| 4| 4| 4| 4| 8| 0| 6| 2| 4| |
| 0| 2| 1| 2| 1| 0| 3| 2| 1| 4| 1| 9| 0| 2| 9| 2| 1| 0| 2| 0| 9| 1| 1| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Eosinophilic Focus | X X X X X| 14 |
Hematopoietic Cell Proliferation | | 2 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 2 1 | 22 1.0|
Mixed Cell Focus | X X X X X X X X | 10 |
Necrosis | 2 1 | 3 1.3|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Bile Duct, Cyst | 2 | 2 1.5|
Bile Duct, Hyperplasia | 1 3 2 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Inflammation | | 1 3.0|
Fat, Necrosis | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 3 3.0|
Cytoplasmic Alteration | | 1 1.0|
Inflammation | 2 | 1 2.0|
Duct, Cyst | 4 | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 2| 4| 4| 4| 2| 4| 5| 4| 4| 3| 4| 5| 4| 4| 9| 9| 4| 4| 4| 4| 8| 0| 6| 2| 4| |
| 0| 2| 1| 2| 1| 0| 3| 2| 1| 4| 1| 9| 0| 2| 9| 2| 1| 0| 2| 0| 9| 1| 1| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Capsule, Hyperplasia, Adenomatous | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3| 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + M + + + M + M + + + + + + + + + + + + +| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 4 1 1 4 2 2 2 2 4 2 2 1| 25 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | | 1 3.0|
Follicular Cell, Hyperplasia | 1 1 4 2 1 1 4 1 1 2| 26 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 2 4 2| 10 2.8|
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | | 1 4.0|
Metaplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 3 4 2 2 2 2 1 2 2 3 3 2| 21 2.5|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Lymphatic, Angiectasis | | 1 3.0|
Lymphatic, Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 3 2 2 2 | 12 2.5|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 7 |
Mediastinal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 2| 4| 4| 4| 2| 4| 5| 4| 4| 3| 4| 5| 4| 4| 9| 9| 4| 4| 4| 4| 8| 0| 6| 2| 4| |
| 0| 2| 1| 2| 1| 0| 3| 2| 1| 4| 1| 9| 0| 2| 9| 2| 1| 0| 2| 0| 9| 1| 1| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 4 2 3 3 3 3 3 4 3 3 3 | 19 2.8|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + M M + M M + + + + + + + + + + M +| 38 |
Atrophy | 2 4 | 5 2.8|
Hyperplasia, Lymphoid | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 5 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Exudate | 2| 1 2.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 1 2| 4 1.3|
Skin, Site of Application, | | |
Inflammation, Chronic | 1 1 1 | 4 1.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Neuron, Necrosis | 1 | 2 1.5|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation | 1 | 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| |
DAY ON TEST | 2| 4| 4| 4| 2| 4| 5| 4| 4| 3| 4| 5| 4| 4| 9| 9| 4| 4| 4| 4| 8| 0| 6| 2| 4| |
| 0| 2| 1| 2| 1| 0| 3| 2| 1| 4| 1| 9| 0| 2| 9| 2| 1| 0| 2| 0| 9| 1| 1| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 2| 2 1.5|
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
Mineralization | | 1 2.0|
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 | 22 1.2|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 0| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 4| 1| 4| 4| 3| 2| 4| 4| 4| 4|
| 0| 4| 0| 1| 6| 1| 6| 1| 0| 1| 0| 0| 0| 0| 5| 1| 8| 1| 0| 8| 4| 1| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
182 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + |
Inflammation | |
__________________________________________________________________________|
Gallbladder | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X|
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X |
Necrosis | 2 1 2 |
Bile Duct, Hyperplasia | 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + |
Degeneration | 1 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 4 1 2 1 1 4 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 0| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 4| 1| 4| 4| 3| 2| 4| 4| 4| 4|
| 0| 4| 0| 1| 6| 1| 6| 1| 0| 1| 0| 0| 0| 0| 5| 1| 8| 1| 0| 8| 4| 1| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
182 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + |
__________________________________________________________________________|
Ovary | + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + |
Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Hemorrhage | 4 |
__________________________________________________________________________|
Spleen | + + + + + + |
Hematopoietic Cell Proliferation | 3 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + |
Atrophy | 2 4 2 4 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Exudate | 1 1 |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 2 |
Epidermis, Skin, Site of Application,| |
Ulcer | 2 |
Skin, Site of Application, | |
Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Neuron, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 0| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 4| 1| 4| 4| 3| 2| 4| 4| 4| 4|
| 0| 4| 0| 1| 6| 1| 6| 1| 0| 1| 0| 0| 0| 0| 5| 1| 8| 1| 0| 8| 4| 1| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
182 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + |
__________________________________________________________________________|
Nose | + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Nephropathy | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 3| 6| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 0| 6| 4| 4| 4| 1| 5| 4| 4| 3| 2| 4| 1| 4| 4| 4| 4| 1| 6| 3| 4| 4| 4| 4| |
| 0| 4| 6| 2| 0| 2| 8| 9| 1| 0| 7| 5| 1| 1| 2| 0| 0| 0| 2| 7| 1| 2| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
182 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 16 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X | 3 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X X | 11 |
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Inflammation, Chronic Active | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 | 28 1.1|
Mixed Cell Focus | X X | 3 |
Necrosis | 1 | 4 1.5|
Bile Duct, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 17 |
Duct, Cyst | 4 | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + | 17 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 17 |
Degeneration | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + | 17 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + + M | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 3| 6| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 0| 6| 4| 4| 4| 1| 5| 4| 4| 3| 2| 4| 1| 4| 4| 4| 4| 1| 6| 3| 4| 4| 4| 4| |
| 0| 4| 6| 2| 0| 2| 8| 9| 1| 0| 7| 5| 1| 1| 2| 0| 0| 0| 2| 7| 1| 2| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
182 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia | 4 1 4 1 | 6 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 2 2 1 3 2 1 1 1 1 1 1| 19 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + | 17 |
Hyperplasia, Cystic | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 17 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + | 17 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 17 |
Hematopoietic Cell Proliferation | 4 3 4 2 3 | 8 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + | 16 |
Atrophy | 2 2 3 | 7 2.7|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + | 17 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epidermis, Skin, Site of Application,| | |
Exudate | 1 1 | 4 1.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | | 1 2.0|
Epidermis, Skin, Site of Application,| | |
Ulcer | | 1 2.0|
Skin, Site of Application, | | |
Inflammation, Chronic | | 1 2.0|
Subcutaneous Tissue, Edema | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 3| 6| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 0| 6| 4| 4| 4| 1| 5| 4| 4| 3| 2| 4| 1| 4| 4| 4| 4| 1| 6| 3| 4| 4| 4| 4| |
| 0| 4| 6| 2| 0| 2| 8| 9| 1| 0| 7| 5| 1| 1| 2| 0| 0| 0| 2| 7| 1| 2| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
182 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 17 |
Neuron, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 17 |
Nephropathy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 5| 3| 4| 4| 7| 7| 4| 4| 3| 7| 8| 2| 8| 4| 6| 4| 4| 4| 4| 4| 4| 4| 0| 7|
| 2| 9| 6| 1| 1| 2| 4| 2| 0| 2| 9| 8| 8| 5| 0| 2| 0| 0| 1| 1| 2| 2| 0| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
364 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 1 1 1|
Mixed Cell Focus | X |
Necrosis | 1 1 1 2 2 2 1 1|
Bile Duct, Hyperplasia | 1 1 |
Serosa, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + +|
Atrophy | 3 |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + +|
Epicardium, Inflammation, Suppurative| 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + +|
Hyperplasia | 1 2|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 1 2 2 2 2 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 5| 3| 4| 4| 7| 7| 4| 4| 3| 7| 8| 2| 8| 4| 6| 4| 4| 4| 4| 4| 4| 4| 0| 7|
| 2| 9| 6| 1| 1| 2| 4| 2| 0| 2| 9| 8| 8| 5| 0| 2| 0| 0| 1| 1| 2| 2| 0| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
364 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 1 1 1 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + +|
Cyst | 2 |
Thrombosis | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Cystic | 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 4 4 4 2 4|
__________________________________________________________________________|
Thymus | + + + + M + + M + + + +|
Atrophy | 4 3 4|
Cyst | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Exudate | 1 2 |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 3 |
Epidermis, Skin, Site of Application,| |
Ulcer | 2 |
Skin, Site of Application, | |
Inflammation, Chronic | |
Skin, Site of Application, | |
Parakeratosis | |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic Active | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 5| 3| 4| 4| 7| 7| 4| 4| 3| 7| 8| 2| 8| 4| 6| 4| 4| 4| 4| 4| 4| 4| 0| 7|
| 2| 9| 6| 1| 1| 2| 4| 2| 0| 2| 9| 8| 8| 5| 0| 2| 0| 0| 1| 1| 2| 2| 0| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
364 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + +|
Inflammation | |
Neuron, Necrosis | 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + +|
Thrombosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 1 1 1 1 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 2| 0| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 4| 4| 4| |
| 2| 2| 1| 1| 2| 1| 1| 1| 1| 1| 2| 1| 2| 0| 2| 1| 0| 4| 0| 2| 2| 1| 0| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
364 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 18 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 18 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Eosinophilic Focus | X X X X | 11 |
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 2 2 1 1 1 1 1 1 1 | 24 1.1|
Mixed Cell Focus | | 1 |
Necrosis | 1 | 9 1.3|
Bile Duct, Hyperplasia | 1 1 | 4 1.0|
Serosa, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 18 |
Atrophy | | 1 3.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 18 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 18 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 18 |
Epicardium, Inflammation, Suppurative| | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 18 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 18 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 18 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 2| 0| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 4| 4| 4| |
| 2| 2| 1| 1| 2| 1| 1| 1| 1| 1| 2| 1| 2| 0| 2| 1| 0| 4| 0| 2| 2| 1| 0| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
364 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 18 |
Pars Distalis, Hyperplasia | 1 2 1 | 11 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 3.0|
Follicular Cell, Hyperplasia | 1 2 1 3 1 3 2 2| 19 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + | 15 |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 18 |
Cyst | 4 | 2 3.0|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 18 |
Hemorrhage | | 1 4.0|
Hyperplasia, Cystic | 2 | 4 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 18 |
Hyperplasia | | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 17 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 18 |
Hematopoietic Cell Proliferation | 4 1 2 3 2 | 12 3.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 16 |
Atrophy | 3 | 4 3.5|
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + | 16 |
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Exudate | 2 1 | 4 1.5|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 1 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 2| 0| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 4| 4| 4| |
| 2| 2| 1| 1| 2| 1| 1| 1| 1| 1| 2| 1| 2| 0| 2| 1| 0| 4| 0| 2| 2| 1| 0| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
364 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Epidermis, Skin, Site of Application,| | |
Ulcer | | 1 2.0|
Skin, Site of Application, | | |
Inflammation, Chronic | 1 | 1 1.0|
Skin, Site of Application, | | |
Parakeratosis | 1 | 1 1.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic Active | | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 18 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 18 |
Inflammation | 2 | 1 2.0|
Neuron, Necrosis | 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 18 |
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 18 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 18 |
Infarct | 3 | 1 3.0|
Nephropathy | 1 | 6 1.0|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 0| 4| 1| 4| 4| 4| 1| 4| 4| 4| 2| 8| 3| 4| 4| 4| 4| 3| 9| 4| 4| 4|
| 0| 0| 1| 3| 2| 7| 0| 2| 1| 2| 1| 2| 1| 9| 6| 4| 1| 0| 1| 2| 0| 4| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
727 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | |
Infarct | |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 |
Mixed Cell Focus | X X X |
Necrosis | |
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Necrosis | 2 2 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 4|
Cytoplasmic Alteration | 1 |
Necrosis | 2 |
Duct, Cyst | 4 4 4|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 0| 4| 1| 4| 4| 4| 1| 4| 4| 4| 2| 8| 3| 4| 4| 4| 4| 3| 9| 4| 4| 4|
| 0| 0| 1| 3| 2| 7| 0| 2| 1| 2| 1| 2| 1| 9| 6| 4| 1| 0| 1| 2| 0| 4| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
727 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + M + + M + M + M M + + M M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3 1 1 2 2 1 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 3 1 1 1 4 1 1 1 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | 2 4 2 3 3|
__________________________________________________________________________|
Oviduct | |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 4 1 3 4 1 1 1 1 2 2 2 1 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 2|
Myelofibrosis | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M + M + + + + + + M + + +|
Atrophy | 4 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Exudate | |
Epidermis, Skin, Site of Application,| |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 0| 4| 1| 4| 4| 4| 1| 4| 4| 4| 2| 8| 3| 4| 4| 4| 4| 3| 9| 4| 4| 4|
| 0| 0| 1| 3| 2| 7| 0| 2| 1| 2| 1| 2| 1| 9| 6| 4| 1| 0| 1| 2| 0| 4| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
727 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia | 1 1 1 |
Epidermis, Skin, Site of Application,| |
Ulcer | 3 |
Skin, Site of Application, | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy | 1 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 3| 4| 4| 4| 7| 0| 4| 4| 4| 4| |
| 0| 2| 0| 2| 7| 5| 0| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 0| 2| 2| 7| 1| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
727 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Eosinophilic Focus | X X X X X| 10 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Infarct | 4 | 1 4.0|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 2 | 21 1.1|
Mixed Cell Focus | X X X X | 7 |
Necrosis | 1 1 4 | 3 2.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Bile Duct, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 12 |
Fat, Necrosis | 2 3 3 2 | 7 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 4 | 6 3.3|
Cytoplasmic Alteration | | 1 1.0|
Necrosis | | 1 2.0|
Duct, Cyst | 4 3 | 5 3.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 3| 4| 4| 4| 7| 0| 4| 4| 4| 4| |
| 0| 2| 0| 2| 7| 5| 0| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 0| 2| 2| 7| 1| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
727 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 4 | 1 4.0|
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + M M M + + + + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 1 2 2 4 2 2 2 1 2 4 1 4 4 2 3 1 | 26 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 2 1 1 2 1 1 1 1 1 2 | 25 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + + + + + + + M + + M + + + + + +| 46 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 2 2 3 2 3 4 3 | 13 2.8|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 2 2 2 1 2 3 4 | 22 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 3 3 | 11 2.8|
Myelofibrosis | 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 6 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 4 3 3 3 3 3 2 3| 11 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 3| 4| 4| 4| 7| 0| 4| 4| 4| 4| |
| 0| 2| 0| 2| 7| 5| 0| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 0| 2| 2| 7| 1| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
727 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + M + + + + + +| 44 |
Atrophy | 2 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Exudate | 4 | 1 4.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 3 | 4 1.5|
Epidermis, Skin, Site of Application,| | |
Ulcer | | 1 3.0|
Skin, Site of Application, | | |
Inflammation, Chronic | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Bronchiole, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 3| 4| 4| 4| 7| 0| 4| 4| 4| 4| |
| 0| 2| 0| 2| 7| 5| 0| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 0| 2| 2| 7| 1| 2| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
727 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 5| 4| 3| 0| 3| 9| 7| 8| 3| 8| 3| 3| 4| 3| 3| 3| 3| 9| 3| 3| 3| 0|
| 4| 1| 5| 1| 7| 5| 6| 4| 0| 5| 7| 5| 0| 3| 4| 6| 5| 5| 5| 3| 7| 3| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + I + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | 2 1 1 |
Hemorrhage | 4|
Inflammation, Chronic Active | 2 2 4 3 3 3 2 2 3 3 3 3 3 3 1 3 3 3 2 4 3 3 1|
Mixed Cell Focus | X |
Necrosis | 3 3 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 3 3 3 2 2 4 2 3 3 4 2 2 2 3 1 2 3 3 4 2 4 2 2 1|
Kupffer Cell, Pigmentation | |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation, Chronic Active | 2 |
Fat, Inflammation | |
Vein, Thrombosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Cytoplasmic Alteration | 1 |
Necrosis | 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 1 |
Ulcer | 2 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 5| 4| 3| 0| 3| 9| 7| 8| 3| 8| 3| 3| 4| 3| 3| 3| 3| 9| 3| 3| 3| 0|
| 4| 1| 5| 1| 7| 5| 6| 4| 0| 5| 7| 5| 0| 3| 4| 6| 5| 5| 5| 3| 7| 3| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 1|
Artery, Inflammation, Chronic Active | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Hyperplasia | 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Duct, Cyst | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 3 3 3 2 2 3 2 2 3|
Infiltration Cellular, Mast Cell | 3|
Infiltration Cellular, Plasma Cell | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hematopoietic Cell | |
Proliferation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 5| 4| 3| 0| 3| 9| 7| 8| 3| 8| 3| 3| 4| 3| 3| 3| 3| 9| 3| 3| 3| 0|
| 4| 1| 5| 1| 7| 5| 6| 4| 0| 5| 7| 5| 0| 3| 4| 6| 5| 5| 5| 3| 7| 3| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 3|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 2 3 1 3 3 2 3 3 3 4|
Lymphoid Follicle, Hyperplasia | |
__________________________________________________________________________|
Thymus | M + + + + + M M + + + + + + + + M + + + M + + + M|
Atrophy | 3 2 3 3 3 3 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + M M M + M M M + M + M M + + + M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Hyperplasia | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinum, Angiectasis | 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 1 |
Glomerulosclerosis | 2 3 |
Infarct | |
Nephropathy | 1 1 1 1 1 1 1 1 2 1 4 1 1 1 1 1 1 1 1 1|
Pigmentation, Hemosiderin | 1 |
Glomerulus, Infarct | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 7| 9| 9| 3| 3| 3| 3| 3| 3| 3| 7| |
| 5| 4| 3| 4| 3| 4| 4| 3| 3| 3| 6| 2| 5| 3| 5| 4| 1| 3| 5| 4| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X | 2 |
Clear Cell Focus | | 4 |
Eosinophilic Focus | X X X X X X | 13 |
Hematopoietic Cell Proliferation | | 3 1.3|
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | 3 1 3 3 1 1 4 3 2 3 2 2 4 3 2 2 2 4 1 2 2 3 1| 46 2.5|
Mixed Cell Focus | X X | 3 |
Necrosis | 2 1 1 1 2 | 8 1.9|
Thrombosis | 3 | 1 3.0|
Bile Duct, Hyperplasia | 4 1 2 3 3 2 2 2 2 3 3 2 2 2 3 3 1 3 1| 43 2.5|
Kupffer Cell, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Artery, Inflammation, Chronic Active | | 1 2.0|
Fat, Inflammation | 2 | 1 2.0|
Vein, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 3 1.7|
Cytoplasmic Alteration | 1 1 1 | 4 1.0|
Necrosis | | 1 2.0|
Artery, Inflammation, Chronic Active | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hyperplasia, Focal | | 1 1.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 7| 9| 9| 3| 3| 3| 3| 3| 3| 3| 7| |
| 5| 4| 3| 4| 3| 4| 4| 3| 3| 3| 6| 2| 5| 3| 5| 4| 1| 3| 5| 4| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 1 1 | 2 1.0|
Mineralization | | 1 1.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
Atrium, Thrombosis | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.0|
Hyperplasia | 1 1 2 1 1 4| 11 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 9 1.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + M + + + + + + + + M +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Cyst | 1 1 | 2 1.0|
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 4 1 1 | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
Duct, Cyst | 3 4 3 3 | 7 3.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 7| 9| 9| 3| 3| 3| 3| 3| 3| 3| 7| |
| 5| 4| 3| 4| 3| 4| 4| 3| 3| 3| 6| 2| 5| 3| 5| 4| 1| 3| 5| 4| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 1 2.0|
Hyperplasia | 2 2 2 3 3 2 3 3| 17 2.5|
Infiltration Cellular, Mast Cell | | 1 3.0|
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M M + + + + + + M + + + + M + + + + M| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 3 1 3 2 2 2 3 3| 27 2.4|
Lymphoid Follicle, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + M + + + M M + + M + + + + M + + M + +| 37 |
Atrophy | 3 3| 9 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M + M M M M + M + M + M + M M M + + M M M M| 18 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 | 1 1.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinum, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 7| 9| 9| 3| 3| 3| 3| 3| 3| 3| 7| |
| 5| 4| 3| 4| 3| 4| 4| 3| 3| 3| 6| 2| 5| 3| 5| 4| 1| 3| 5| 4| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 1 | 5 2.0|
Glomerulosclerosis | | 2 2.5|
Infarct | 2 | 1 2.0|
Nephropathy | 1 2 1 1 1 1 1 2 1 1 1 3 1 1 3 1 1 2 1 1 1 1 2| 43 1.3|
Pigmentation, Hemosiderin | | 1 1.0|
Glomerulus, Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 5| 3| 8| 3| 3|
| 4| 5| 4| 4| 5| 3| 5| 5| 2| 2| 4| 5| 4| 4| 4| 7| 0| 4| 5| 5| 8| 4| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
182 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | M + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X X X|
Inflammation, Chronic Active | 4 4 4 3 3 3 3 4 1 3 3 3 3 3 3 3 4 1 3 3 1|
Mixed Cell Focus | X |
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | 3 4 3 2 3 3 2 3 3 3 3 4 2 2 1 4 1 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + |
Degeneration | 1 |
Atrium, Thrombosis | 4 |
Ventricle, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 5| 3| 8| 3| 3|
| 4| 5| 4| 4| 5| 3| 5| 5| 2| 2| 4| 5| 4| 4| 4| 7| 0| 4| 5| 5| 8| 4| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
182 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Duct, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + |
Hematopoietic Cell Proliferation | 4 2 4 3 |
__________________________________________________________________________|
Thymus | + + + + + M + |
Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Exudate | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Neuron, Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Glomerulosclerosis | 3 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 5| 3| 8| 3| 3|
| 4| 5| 4| 4| 5| 3| 5| 5| 2| 2| 4| 5| 4| 4| 4| 7| 0| 4| 5| 5| 8| 4| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
182 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 4 1 1 1 4 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| 8| |
| 5| 5| 0| 4| 9| 3| 3| 4| 5| 3| 4| 3| 0| 4| 3| 6| 4| 3| 4| 3| 4| 5| 9| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
182 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + +| 13 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + +| 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + +| 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M + +| 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + +| 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 2.5|
Basophilic Focus | X X | 6 |
Clear Cell Focus | | 3 |
Eosinophilic Focus | X X X | 11 |
Inflammation, Chronic Active | 4 3 3 4 2 3 4 3 4 1 4 3 2 2 2 3 2 2 2 3 3 1 1| 44 2.8|
Mixed Cell Focus | X X X | 4 |
Necrosis | 1 4 3 1 | 5 2.2|
Vacuolization Cytoplasmic | 1 | 2 2.0|
Bile Duct, Hyperplasia | 3 3 3 4 2 2 3 3 3 4 3 4 2 2 3 3 1 3 2 3 3 3| 41 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + +| 13 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + +| 13 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + +| 13 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + +| 13 |
__________________________________________________________________________|____________|
Heart | + + + + + +| 13 |
Degeneration | | 1 1.0|
Atrium, Thrombosis | | 1 4.0|
Ventricle, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + M + +| 12 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + M + +| 12 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A| 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + +| 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + +| 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + +| 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| 8| |
| 5| 5| 0| 4| 9| 3| 3| 4| 5| 3| 4| 3| 0| 4| 3| 6| 4| 3| 4| 3| 4| 5| 9| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
182 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + +| 13 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + +| 13 |
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + +| 13 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + +| 13 |
__________________________________________________________________________|____________|
Testes | + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + +| 13 |
Hyperplasia | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + M| 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + M| 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + +| 13 |
Hematopoietic Cell Proliferation | 3 4 3 4 | 8 3.4|
__________________________________________________________________________|____________|
Thymus | + + + + M +| 11 |
Atrophy | 4 3 2 | 5 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M +| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Exudate | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + +| 13 |
Neuron, Necrosis | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + +| 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| 8| |
| 5| 5| 0| 4| 9| 3| 3| 4| 5| 3| 4| 3| 0| 4| 3| 6| 4| 3| 4| 3| 4| 5| 9| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
182 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + +| 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + +| 13 |
Glomerulosclerosis | | 1 3.0|
Nephropathy | 2 1 1 1| 10 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + +| 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 4| 3| 3| 6| 3| 3| 7| 4| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 8| 5| 3| 1| 4| 4| 2| 4| 4| 5| 5| 8| 3| 3| 5| 7| 5| 3| 5| 6| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
364 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Inflammation, Chronic Active | 4 3 1 2 2 1 3 4 2 3 3 1 2 3 1 3 3 2 3 3 1|
Mixed Cell Focus | X |
Necrosis | 4 |
Thrombosis | 4 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 3 3 2 2 2 2 3 4 1 2 3 1 2 3 4 1 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Atrophy | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
Necrosis | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + |
Aorta, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + |
Degeneration | 2 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + |
Accessory Adrenal Cortical Nodule | 1 |
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 4| 3| 3| 6| 3| 3| 7| 4| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 8| 5| 3| 1| 4| 4| 2| 4| 4| 5| 5| 8| 3| 3| 5| 7| 5| 3| 5| 6| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
364 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + M M M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + |
Duct, Cyst | 4 3 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + |
Degeneration | 3 |
Artery, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + |
Degeneration | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + M + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 4 3 2 3 |
__________________________________________________________________________|
Thymus | + M M + M + M + |
Atrophy | 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Exudate | |
Epidermis, Skin, Site of Application,| |
Hyperkeratosis | |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 1 |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 4| 3| 3| 6| 3| 3| 7| 4| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 8| 5| 3| 1| 4| 4| 2| 4| 4| 5| 5| 8| 3| 3| 5| 7| 5| 3| 5| 6| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
364 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Inflammation | 2 |
Artery, Inflammation, Chronic Active | 2 |
Neuron, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Inflammation | 2 |
Pigmentation, Hemosiderin | 2 |
Thrombosis | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Nephropathy | 1 1 1 1 1 |
Pigmentation, Hemosiderin | 4 |
Artery, Inflammation, Chronic Active | 3 |
Glomerulus, Thrombosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 4| 4| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 2| 6| 4| 3| 5| 3| 4| 3| 4| 5| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
364 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 3 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | X X X X X X| 12 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | 4 | 1 4.0|
Inflammation, Chronic Active | 3 3 3 1 3 2 4 4 4 1 3 4 4 1 1 1 2 3 3 3 | 41 2.5|
Mixed Cell Focus | X X X X | 5 |
Necrosis | 1 | 2 2.5|
Thrombosis | | 1 4.0|
Vacuolization Cytoplasmic | | 1 2.0|
Bile Duct, Hyperplasia | 3 3 3 1 3 2 3 4 3 1 3 4 4 2 2 3 3 3 | 36 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + | 11 |
Atrophy | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 11 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 11 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 11 |
Aorta, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + | 11 |
Degeneration | | 1 2.0|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 11 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 4| 4| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 2| 6| 4| 3| 5| 3| 4| 3| 4| 5| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
364 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 11 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 11 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 11 |
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 10 |
Duct, Cyst | | 4 3.8|
__________________________________________________________________________|____________|
Prostate | + + + | 11 |
Degeneration | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 11 |
Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + | 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 11 |
Hyperplasia | 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 10 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 12 |
Hematopoietic Cell Proliferation | 3 2 | 8 2.6|
__________________________________________________________________________|____________|
Thymus | + M + | 6 |
Atrophy | | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 4| 4| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 2| 6| 4| 3| 5| 3| 4| 3| 4| 5| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
364 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Exudate | 1 | 1 1.0|
Epidermis, Skin, Site of Application,| | |
Hyperkeratosis | 2 | 1 2.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 1 | 4 1.3|
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 11 |
Inflammation | | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Neuron, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 15 |
Inflammation | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + | 11 |
__________________________________________________________________________|____________|
Trachea | + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 11 |
Nephropathy | 1 1 1 | 8 1.0|
Pigmentation, Hemosiderin | | 1 4.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
Glomerulus, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 0| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 4| 4| 3| 3| 4| 5| 9| 5| 7| 3| 4| 5| 3| 1| 5| 3| 4| 3| 3| 3| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
727 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X|
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X X X X |
Inflammation, Chronic Active | 2 1 1 3 3 2 3 2 2 3 3 2 4 3 3 3 3 4 2 3|
Mixed Cell Focus | X X X|
Necrosis | 2 1 3 4 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 1 3 3 4 3 3 2 2 2 2 3 2 2 3 4 4 1 3|
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 4 |
Artery, Inflammation, Chronic Active | 4 |
Vein, Thrombosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Mineralization | 1 |
Artery, Inflammation, Chronic Active | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 0| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 4| 4| 3| 3| 4| 5| 9| 5| 7| 3| 4| 5| 3| 1| 5| 3| 4| 3| 3| 3| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
727 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | |
Degeneration, Cystic | 1 |
Hemorrhage | 4 |
Hyperplasia | 1 1 1 1 1 1 1 1 2 |
Inflammation, Chronic Active | |
Capsule, Hyperplasia, Adenomatous | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + M +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Pars Distalis, Hyperplasia | 3 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Duct, Cyst | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 3 3 3 3 3 3 3 4 3 3 |
Thrombosis | 2 |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 0| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 4| 4| 3| 3| 4| 5| 9| 5| 7| 3| 4| 5| 3| 1| 5| 3| 4| 3| 3| 3| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
727 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 4 4 1 2 3 1 1 3 2 1 |
Lymphoid Follicle, Depletion Cellular| |
__________________________________________________________________________|
Thymus | + + + M + + + + M M M + + + + M M + + M + M M + +|
Atrophy | 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M + M M M M + M M + + + M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Exudate | |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 1 1 |
Epidermis, Skin, Site of Application,| |
Ulcer | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpus Callosum, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 2 1 1 |
Glomerulosclerosis | |
Hydronephrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 0| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 4| 4| 3| 3| 4| 5| 9| 5| 7| 3| 4| 5| 3| 1| 5| 3| 4| 3| 3| 3| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
727 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct | 1 |
Mineralization | 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation, Hemosiderin | |
Artery, Inflammation, Chronic Active | 3 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 1| 3| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 5| 3| 5| 3| 3| 1| 3| 8| |
| 5| 4| 2| 5| 7| 5| 3| 3| 4| 4| 1| 3| 5| 4| 1| 4| 5| 7| 3| 8| 4| 5| 2| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
727 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X | 4 |
Clear Cell Focus | X X | 8 |
Eosinophilic Focus | X X X X X | 9 |
Inflammation, Chronic Active | 2 3 3 4 1 3 3 1 1 2 1 1 1 4 1 4 4 1 3 3 3 1 3| 43 2.4|
Mixed Cell Focus | X X X X | 7 |
Necrosis | 4 2 1 2| 8 2.4|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 3 4 3 2 2 1 1 3 3 1 4 2 3 4 3 2 4 1| 37 2.6|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Hemorrhage | | 1 4.0|
Artery, Inflammation, Chronic Active | | 1 4.0|
Vein, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 1 | 1 1.0|
Mineralization | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 1| 3| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 5| 3| 5| 3| 3| 1| 3| 8| |
| 5| 4| 2| 5| 7| 5| 3| 3| 4| 4| 1| 3| 5| 4| 1| 4| 5| 7| 3| 8| 4| 5| 2| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
727 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Degeneration, Cystic | | 1 1.0|
Hemorrhage | | 1 4.0|
Hyperplasia | 3 1 1 1 1 1 2 1 1 1 | 19 1.2|
Inflammation, Chronic Active | 1 | 1 1.0|
Capsule, Hyperplasia, Adenomatous | 3 1 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 1 3 | 9 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + M + + + + + + + M + + M + + M +| 42 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 1.0|
Pars Distalis, Hyperplasia | | 2 2.5|
Pars Intermedia, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 1 1 2 | 10 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 1 | 2 1.5|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Cyst | 3 3 3 3| 6 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 4 | 2 3.0|
Artery, Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 1| 3| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 5| 3| 5| 3| 3| 1| 3| 8| |
| 5| 4| 2| 5| 7| 5| 3| 3| 4| 4| 1| 3| 5| 4| 1| 4| 5| 7| 3| 8| 4| 5| 2| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
727 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 2 2 3 3 2 3| 23 2.9|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
Mediastinal, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + M + + + M + M + M + M| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + M + + + + + + + + + + +| 47 |
Hyperplasia, Histiocytic | 3 | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 1 2 2 3 3 1 3 4| 25 2.3|
Lymphoid Follicle, Depletion Cellular| 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + M + + + M + + M + + + + M + + + M +| 34 |
Atrophy | 4 4 2| 6 3.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M M M M M M M M + + M M M + M + M M M M +| 15 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Exudate | 3 | 1 3.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 3 1 | 5 1.4|
Epidermis, Skin, Site of Application,| | |
Ulcer | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpus Callosum, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05188-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 14:07:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 1| 3| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 5| 3| 5| 3| 3| 1| 3| 8| |
| 5| 4| 2| 5| 7| 5| 3| 3| 4| 4| 1| 3| 5| 4| 1| 4| 5| 7| 3| 8| 4| 5| 2| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
727 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 2 1 | 8 1.3|
Glomerulosclerosis | 1 2 4 2 | 4 2.3|
Hydronephrosis | | 1 4.0|
Infarct | | 1 1.0|
Mineralization | 1 1 1 | 4 1.3|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1| 43 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
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---------- END OF REPORT ----------
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