TDMS Study 05188-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus SODIUM XYLENESULFONATE DATE: 04/04/96
EXPERIMENT: 05188 TEST: 06 TIME: 05:13:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05293 ROUTE: SKIN APPLICATION NTP C#: 55403D
PATHOLOGIST: SINGER, A. CAS: 1300-72-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus SODIUM XYLENESULFONATE DATE: 04/04/96
EXPERIMENT: 05188 TEST: 06 TIME: 05:13:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05293 ROUTE: SKIN APPLICATION NTP C#: 55403D
PATHOLOGIST: SINGER, A. CAS: 1300-72-7
SODIUM XYLENESULFONATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 494 564 575 575 646 647 651 674 680 686 |
| 687 690 691 691 697 702 705 706 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 182 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 322 540 588 610 620 639 658 659 674 680 |
| 687 702 706 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 364 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 506 548 561 572 612 636 644 686 687 718 |
| 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SODIUM XYLENESULFONATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 727 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 457 543 569 585 621 631 634 658 664 691 |
| 707 707 712 712 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SODIUM XYLENESULFONATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 86.0 64.0 |
| | |
| | |
|182 | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 94.0 84.0 74.0 |
|MG/KG | |
| | |
|364 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 86.0 78.0 |
|MG/KG | |
| | |
|727 | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 92.0 82.0 70.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 182 364 727 |
| MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.0% 74.0% 78.0% 70.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.681N P=0.440N P=0.218N P=0.635N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 653.4 621.9 626.5 640.8 |
|NATURAL DEATHS (C) | (14.3) (28.3) (22.0) (19.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 704.3 704.1 709.6 705.3 |
|(STANDARD ERROR) | ( 7.5) (10.0) ( 7.8) ( 8.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM XYLENESULFONATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 740 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 292 453 461 495 499 589 620 621 621 659 |
| 659 670 679 680 692 701 722 726 734 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 182 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 1 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 24 337 411 446 467 538 604 625 636 642 |
| 659 666 674 712 718 731 735 |
| CENSORED DEATHS |
| 618 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 364 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 561 562 575 588 601 602 622 636 642 654 |
| 659 661 672 674 679 685 728 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SODIUM XYLENESULFONATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 740 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 727 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 72 403 534 612 627 629 675 686 691 694 |
| 707 717 730 738 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SODIUM XYLENESULFONATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 740 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 740 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 98.0 94.0 90.0 88.0 78.0 62.0 |
| | |
| | |
|182 | 98.0 98.0 98.0 96.0 94.0 90.0 88.0 86.0 77.8 65.5 |
|MG/KG | |
| | |
|364 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 88.0 76.0 64.0 |
|MG/KG | |
| | |
|727 | 98.0 98.0 98.0 98.0 96.0 96.0 94.0 94.0 88.0 72.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 182 364 727 |
| MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 65.5% 64.0% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.305N P=0.896N P=0.967N P=0.335N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 609.1 566.2 640.7 608.2 |
|NATURAL DEATHS (C) | (27.0) (44.6) (12.2) (47.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 690.3 678.5 704.3 703.1 |
|(STANDARD ERROR) | (13.6) (19.0) ( 8.1) (15.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM XYLENESULFONATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
182 MG/KG = 2
364 MG/KG = 3
727 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 4 1 3
|
| 2 4 1 3 23 1
| 23 1412
95 +
| 33 2 2
| 314 22 1
|
P 90 + 32 32
E |
R | 32 2
C | 4312 2 13
E 85 +
N | 4 2 113
T | 4 223 3
|
S 80 + 11 4 33
U |
R | 2 2 3 3
V | 44
I 75 +
V | 2 2
A | 11 44
L |
70 + 11 4 4
|
|
|
65 +
| 1 1
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.
SODIUM XYLENESULFONATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
182 MG/KG = 2
364 MG/KG = 3
727 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 4 1 3
|
| 2 4 1 2 4 1
| 2 42 11 4 3 3
95 +
| 2 2 1 1 4 33 4
| 2 2 11 3 3 4 4
|
P 90 + 2 1 2 1
E |
R | 2 132 14 4
C | 2 323 44
E 85 +
N | 223 44
T | 1 22 3 1 44
|
S 80 + 2 3 2 44
U |
R | 11 4 4
V | 311 4 4
I 75 +
V | 311 2 44
A | 11 4
L | 22
70 + 331 1 2 2
|
| 3 1 1
| 3 3
65 + 22
| 1 13
| 11
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.