TDMS Study 05188-05 Pathology Tables
NEOPLASMS BY INDIVIDUAL ANIMAL
SODIUM XYLENESULFONATE
NTP Experiment-Test: 05188-05 Report: PEIRPT04
Study Type: CHRONIC Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1300-72-7
Lock Date: 07/13/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|
| 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|
| 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Adenoma | |
Leukemia Mononuclear | X|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Leukemia Mononuclear | X|
Mediastinal, Leukemia Mononuclear | X X X X|
Pancreatic, Leukemia Mononuclear | X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pinna, Squamous Cell Papilloma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|
| 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3| |
| 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 16 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Gingival, Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X| 4 |
Pars Distalis, Adenoma | X X X X X X X X X X| 29 |
Pars Distalis, Adenoma, Multiple | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3| |
| 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Adenoma | X X X X X X X X| 10 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
Leukemia Mononuclear | X| 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroma | | 1 |
Polyp Stromal | X | 2 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 6 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| 45 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | X| 5 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 17 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
Fibroadenoma | X X X X X X X X X | 12 |
Fibroadenoma, Multiple | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3| |
| 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pinna, Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Humerus, Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | X | 1 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
Leukemia Mononuclear | X| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X| 15 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X| 13 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|
| 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Lipoma | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|
| 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Polyp Stromal | |
Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|
| 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lipoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6| |
DAY ON TEST | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9| |
| 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 35 |
Periesophageal Tissue, Lipoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X X| 5 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +| 35 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + +| 35 |
Adenoma | X | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X | 3 |
Pars Distalis, Adenoma | X X X X X X X X| 16 |
Pars Distalis, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +| 35 |
C-Cell, Adenoma | | 1 |
Follicular Cell, Adenoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6| |
DAY ON TEST | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9| |
| 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + +| 35 |
Polyp Stromal | X | 1 |
Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 32 |
Mediastinal, Leukemia Mononuclear | X X| 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X X| 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + +| 35 |
Carcinoma | | 1 |
Fibroadenoma | X| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 35 |
Astrocytoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6| |
DAY ON TEST | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9| |
| 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X X| 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + +| 35 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X X| 4 |
Lipoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X| 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|
DAY ON TEST | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|
| 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
Periesophageal Tissue, Lipoma | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Bilateral, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|
DAY ON TEST | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|
| 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Polyp Stromal | |
Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
Fibroadenoma | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|
DAY ON TEST | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|
| 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9| |
| 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + +| 33 |
Periesophageal Tissue, Lipoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +| 33 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + M + + + + + + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + +| 33 |
Pars Distalis, Adenoma | X X X X X X X | 19 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + +| 33 |
C-Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9| |
| 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 3 |
Carcinoma | X| 1 |
Bilateral, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + +| 33 |
Polyp Stromal | X| 1 |
Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 27 |
Mediastinal, Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 33 |
Fibroadenoma | X X X X | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9| |
| 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|
DAY ON TEST | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|
| 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + M + + + + M + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X|
C-Cell, Adenoma, Multiple | X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|
DAY ON TEST | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|
| 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|
DAY ON TEST | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|
| 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Benign | X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6| |
DAY ON TEST | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5| |
| 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 9 |
__________________________________________________________________________|____________|
Mesentery | + +| 4 |
Leukemia Mononuclear | X| 2 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X| 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 2 |
Pheochromocytoma Benign | X X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 3 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| 27 |
Pars Distalis, Adenoma, Multiple | X | 2 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6| |
DAY ON TEST | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5| |
| 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Adenoma | X X X X | 7 |
C-Cell, Adenoma, Multiple | | 1 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X X | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 1 |
Mesothelioma Benign | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + M + + + + + + M + + + + + + + + + +| 48 |
Leukemia Mononuclear | X| 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Mediastinal, Leukemia Mononuclear | X X| 3 |
Pancreatic, Leukemia Mononuclear | X| 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + M + + + + + + + +| 48 |
Leukemia Mononuclear | X| 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X| 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X| 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | | 1 |
Fibroadenoma | X | 6 |
Fibroadenoma, Multiple | X X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6| |
DAY ON TEST | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5| |
| 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + M + + + + + + M + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X| 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + +| 5 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X| 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X| 10 |
Mesothelioma Benign | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X X |
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Multiple | X |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X X X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X X X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Iliac, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Skin, Site of | |
Application, Carcinoma | X |
Subcutaneous Tissue, Pinna, Melanoma | |
Malignant | X|
Subcutaneous Tissue, Skin, Site of | |
Application, Fibroma, Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Carcinoma, Metastatic, Pituitary | |
Gland | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Skin | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Tubular | X |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X X X |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 12 |
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 3 |
__________________________________________________________________________|____________|
Oral Mucosa | + + | 2 |
Gingival, Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Pheochromocytoma Benign | X X X X X | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + M M + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma, Multiple | | 1 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | 34 |
Pars Distalis, Adenoma, Multiple | X X X X X| 9 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | X X X X X X | 8 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 3 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 5 |
Bilateral, Interstitial Cell, Adenoma| X X X X | 11 |
Interstitial Cell, Adenoma | X X X X X X| 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 41 |
Iliac, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | X X | 4 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 12 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + + M M + + +| 46 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Skin, Site of | | |
Application, Carcinoma | | 1 |
Subcutaneous Tissue, Pinna, Melanoma | | |
Malignant | | 1 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Fibroma, Multiple | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | X| 1 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Carcinoma, Metastatic, Skin | | 1 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma, Tubular | | 1 |
Leukemia Mononuclear | X X X X X| 9 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 1 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 3 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X|
Hepatocellular Carcinoma | X |
Leiomyosarcoma, Metastatic, | |
Intestine Small, Jejunum | X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + +|
Carcinoma, Metastatic, Kidney | X|
Leiomyosarcoma, Metastatic, | |
Intestine Small, Jejunum | X |
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X|
Leiomyosarcoma, Metastatic, | |
Intestine Small, Jejunum | X |
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
Carcinoma | X |
Carcinoma, Metastatic, Kidney | X|
Leiomyosarcoma, Metastatic, | |
Intestine Small, Jejunum | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X |
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X|
Leiomyosarcoma, Metastatic, | |
Intestine Small, Jejunum | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
Bilateral, Interstitial Cell, Adenoma| X X |
Interstitial Cell, Adenoma | X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Carcinoma, Metastatic, | |
Kidney | X|
Mediastinal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X|
Leiomyosarcoma, Metastatic, | |
Intestine Small, Jejunum | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + M + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Skin, Site of Application, Basal | |
Cell Adenoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Skin, Site of | |
Application, Fibrous Histiocytoma| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | M + + + + + + + + + + + + + + +|
Rib, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + +|
Carcinoma, Metastatic, Kidney | X|
Leiomyosarcoma, Metastatic, | |
Intestine Small, Jejunum | X |
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X|
Leiomyosarcoma, Metastatic, | |
Intestine Small, Jejunum | X |
Leukemia Mononuclear | X X X |
Mediastinum, Osteosarcoma, | |
Metastatic, Bone | |
__________________________________________________________________________|
Nose | M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X|
Leukemia Mononuclear | X X X |
Sarcoma | X |
Renal Tubule, Carcinoma | X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +| 33 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +| 33 |
Leiomyosarcoma | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +| 33 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + +| 45 |
Carcinoma, Metastatic, Kidney | | 1 |
Hepatocellular Carcinoma | | 1 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small, Jejunum | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 22 |
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small, Jejunum | | 1 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + +| 33 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small, Jejunum | | 1 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +| 33 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +| 33 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X | 1 |
Pheochromocytoma Benign | X X X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +| 33 |
Carcinoma | | 1 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small, Jejunum | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X| 26 |
Pars Distalis, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + +| 33 |
C-Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + +| 33 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + +| 33 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small, Jejunum | | 1 |
Leukemia Mononuclear | X X | 2 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + +| 33 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
Bilateral, Interstitial Cell, Adenoma| | 2 |
Interstitial Cell, Adenoma | X X X | 6 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + +| 32 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 25 |
Leukemia Mononuclear | X | 1 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Inguinal, Leukemia Mononuclear | X | 1 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Carcinoma, Metastatic, | | |
Kidney | | 1 |
Mediastinal, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| 33 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small, Jejunum | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +| 46 |
Fibroma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + +| 31 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 32 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X | 1 |
Skin, Site of Application, Basal | | |
Cell Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Skin, Site of | | |
Application, Fibrous Histiocytoma| X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + +| 32 |
Rib, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small, Jejunum | | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + +| 33 |
Astrocytoma Malignant | X | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + +| 33 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small, Jejunum | | 1 |
Leukemia Mononuclear | X X X X X X | 9 |
Mediastinum, Osteosarcoma, | | |
Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + +| 33 |
Carcinoma, Metastatic, Kidney | | 1 |
Leukemia Mononuclear | X X X X X X | 9 |
Sarcoma | | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|
| 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Leiomyosarcoma, Metastatic, Stomach, | |
Forestomach | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Stomach, | |
Forestomach | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach, | |
Forestomach | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + |
Carcinoma, Metastatic, Kidney | |
Leiomyosarcoma, Metastatic, Stomach, | |
Forestomach | |
Leukemia Mononuclear | |
Sarcoma | X |
__________________________________________________________________________|
Oral Mucosa | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach, | |
Forestomach | |
Leukemia Mononuclear | |
Mixed Tumor Benign | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Sarcoma, Metastatic, Mesentery | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|
| 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Stomach, | |
Forestomach | |
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Leiomyosarcoma, Metastatic, Stomach, | |
Forestomach | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|
| 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mediastinal, Carcinoma, Metastatic, | |
Kidney | |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Leukemia Mononuclear | X |
Renal, Carcinoma, Metastatic, Kidney | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach, | |
Forestomach | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Squamous Cell Papilloma | |
Skin, Site of Application, Basal | |
Cell Adenoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Leukemia | |
Mononuclear | |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Carcinoma, Metastatic, Kidney | |
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Oligodendroglioma Malignant | X |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|
| 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + + |
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Transitional Epithelium, Carcinoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4| |
DAY ON TEST | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8| |
| 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Carcinoma, Metastatic, Kidney | X | 1 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Histiocytic Sarcoma | | 1 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Leukemia Mononuclear | X X X X X X | 14 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Carcinoma, Metastatic, Kidney | X | 1 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Leukemia Mononuclear | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Carcinoma, Metastatic, Kidney | X | 1 |
Histiocytic Sarcoma | | 1 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Leukemia Mononuclear | X | 1 |
Mixed Tumor Benign | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leiomyosarcoma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leiomyosarcoma | X | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4| |
DAY ON TEST | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8| |
| 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Benign | X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Carcinoma, Metastatic, Kidney | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X | 30 |
Pars Distalis, Adenoma, Multiple | X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| 41 |
C-Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + +| 40 |
Adenoma | X | 1 |
Carcinoma | | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Carcinoma, Metastatic, Kidney | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4| |
DAY ON TEST | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8| |
| 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Leiomyosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Bilateral, Interstitial Cell, Adenoma| X X X | 5 |
Interstitial Cell, Adenoma | X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 31 |
Mediastinal, Carcinoma, Metastatic, | | |
Kidney | X | 1 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Leukemia Mononuclear | X | 2 |
Renal, Carcinoma, Metastatic, Kidney | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M +| 40 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Carcinoma, Metastatic, Kidney | X | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Histiocytic Sarcoma | | 1 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Leukemia Mononuclear | X X X X X X X | 15 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | | 1 |
Squamous Cell Papilloma | X | 1 |
Skin, Site of Application, Basal | | |
Cell Adenoma | X | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Leukemia | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4| |
DAY ON TEST | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8| |
| 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mononuclear | X | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Carcinoma, Metastatic, Kidney | X | 1 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Oligodendroglioma Malignant | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Carcinoma, Metastatic, Kidney | X | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X | 9 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Adenoma | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leukemia Mononuclear | X X X X X | 9 |
Renal Tubule, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Leukemia Mononuclear | X | 1 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4| |
DAY ON TEST | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8| |
| 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 4| 6| 5| 7| 7| 6| 6| 6| 5| 7| 7| 7| 5| 5| 7| 4| 3| 7|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 2| 5| 4| 3| 1| 3| 2| 4| 2| 3| 2| 3| 2| 6| 3| 8| 8| 3|
| 5| 5| 7| 5| 8| 1| 5| 8| 8| 7| 5| 9| 8| 9| 2| 4| 5| 6| 5| 5| 1| 0| 0| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Leukemia Mononuclear| X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + + |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Oral Mucosa | + + +|
Gingival, Squamous Cell Carcinoma | X |
Pharyngeal, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 4| 6| 5| 7| 7| 6| 6| 6| 5| 7| 7| 7| 5| 5| 7| 4| 3| 7|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 2| 5| 4| 3| 1| 3| 2| 4| 2| 3| 2| 3| 2| 6| 3| 8| 8| 3|
| 5| 5| 7| 5| 8| 1| 5| 8| 8| 7| 5| 9| 8| 9| 2| 4| 5| 6| 5| 5| 1| 0| 0| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Craniopharyngioma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
Bilateral, C-Cell, Carcinoma | X |
C-Cell, Adenoma | X X X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 4| 6| 5| 7| 7| 6| 6| 6| 5| 7| 7| 7| 5| 5| 7| 4| 3| 7|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 2| 5| 4| 3| 1| 3| 2| 4| 2| 3| 2| 3| 2| 6| 3| 8| 8| 3|
| 5| 5| 7| 5| 8| 1| 5| 8| 8| 7| 5| 9| 8| 9| 2| 4| 5| 6| 5| 5| 1| 0| 0| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 4| 6| 5| 7| 7| 6| 6| 6| 5| 7| 7| 7| 5| 5| 7| 4| 3| 7|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 2| 5| 4| 3| 1| 3| 2| 4| 2| 3| 2| 3| 2| 6| 3| 8| 8| 3|
| 5| 5| 7| 5| 8| 1| 5| 8| 8| 7| 5| 9| 8| 9| 2| 4| 5| 6| 5| 5| 1| 0| 0| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Uncertain Primary Site | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7| |
DAY ON TEST | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2| |
| 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Tissue, Leukemia Mononuclear| | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 25 |
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 3 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 2 |
__________________________________________________________________________|____________|
Oral Mucosa | + + + | 6 |
Gingival, Squamous Cell Carcinoma | | 1 |
Pharyngeal, Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 2 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7| |
DAY ON TEST | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2| |
| 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 11 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X X X X | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 3 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + M + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 4 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | 31 |
Pars Distalis, Adenoma, Multiple | X X X X| 5 |
Pars Distalis, Craniopharyngioma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, C-Cell, Adenoma | X | 1 |
Bilateral, C-Cell, Carcinoma | | 1 |
C-Cell, Adenoma | X| 5 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 2 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7| |
DAY ON TEST | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2| |
| 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 5 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X | 17 |
Interstitial Cell, Adenoma | X X X X X X | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 15 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 41 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X| 24 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Adenoma | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7| |
DAY ON TEST | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2| |
| 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Fibroma | X X | 3 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | +| 2 |
Carcinoma | X| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 22 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 2 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant, Metastatic, | | |
Uncertain Primary Site | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05188-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 20:55:17
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7| |
DAY ON TEST | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2| |
| 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X X X X X| 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
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---------- END OF REPORT ----------
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