TDMS Study 05197-11 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest 2-BUTOXYETHANOL DATE: 02/16/98
EXPERIMENT: 05197 TEST: 11 TIME: 13:20:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-15318 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 62077D
PATHOLOGIST: GRUMBEIN, S. CAS: 111-76-0002
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest 2-BUTOXYETHANOL DATE: 02/16/98
EXPERIMENT: 05197 TEST: 11 TIME: 13:20:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15318 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 62077D
PATHOLOGIST: GRUMBEIN, S. CAS: 111-76-0002
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 354 520 521 529 558 558 563 564 565 568 |
| 597 609 610 617 631 638 641 642 646 648 |
| 648 649 673 683 687 687 697 702 708 708 |
| 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 31.2 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 39 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 465 479 529 533 533 536 544 561 575 576 |
| 579 592 610 617 617 620 627 630 633 638 |
| 646 649 652 652 652 659 664 666 674 677 |
| 688 693 702 704 704 716 722 723 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 62.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 340 370 387 461 472 484 542 549 561 565 |
| 584 612 617 622 627 644 658 666 666 673 |
| 677 687 694 701 703 708 708 716 718 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 125 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 444 481 495 508 517 519 534 575 576 589 |
| 611 617 628 638 647 652 654 659 666 690 |
| 694 695 703 708 718 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 98.0 92.0 78.0 56.0 38.0 |
| | |
| | |
|31.2 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 86.0 76.0 46.0 22.0 |
| | |
| | |
|62.5 PPM | 100.0 100.0 100.0 98.0 94.0 88.0 86.0 78.0 66.0 42.0 |
| | |
| | |
|125 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 86.0 80.0 64.0 48.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 31.2 PPM 62.5 PPM 125 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 38.0% 22.0% 42.0% 48.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.115N P=0.196 P=0.772N P=0.393N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 617.4 627.2 600.4 613.1 |
|NATURAL DEATHS (C) | (13.8) (10.9) (20.4) (16.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 659.8 649.6 654.4 668.7 |
|(STANDARD ERROR) | (11.5) (10.4) (14.8) (11.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 400 508 533 554 558 575 594 617 617 638 |
| 648 652 654 687 688 708 710 718 718 718 |
| 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 31.2 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 495 544 553 561 564 584 606 610 617 638 |
| 652 652 655 666 667 687 691 701 707 708 |
| 722 722 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 62.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 247 390 462 462 496 529 544 544 574 583 |
| 586 589 619 633 648 649 656 666 688 688 |
| 691 694 699 705 708 722 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 125 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 462 472 533 541 571 610 610 612 617 624 |
| 638 646 652 662 663 663 666 667 685 689 |
| 689 689 694 694 695 701 705 705 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 86.0 74.0 58.0 |
| | |
| | |
|31.2 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 88.0 74.0 54.0 |
| | |
| | |
|62.5 PPM | 100.0 100.0 98.0 98.0 96.0 92.0 84.0 76.0 66.0 46.0 |
| | |
| | |
|125 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 92.0 90.0 68.0 42.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 31.2 PPM 62.5 PPM 125 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.0% 54.0% 46.0% 42.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.106 P=0.832 P=0.238 P=0.159 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 629.4 640.5 599.9 640.8 |
|NATURAL DEATHS (C) | (18.6) (13.8) (22.0) (12.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 687.7 688.8 659.7 678.3 |
|(STANDARD ERROR) | (10.5) ( 8.9) (15.0) ( 9.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2-BUTOXYETHANOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
31.2 PPM = 2
62.5 PPM = 3
125 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 4 2
| 3 1 3 4 2 2 1
| 3 3 3 2 4 4 112
| 3 3 44 1 1
90 + 3 3 4 4
| 3 4 22 11
| 423 2 2
| 114 4
P 80 + 31 3 41 4
E | 23 21134
R | 2 1114 4
C | 13144
E 70 + 31144
N | 22 3 3
T | 22113 43
| 22 33 4
S 60 + 22 44
U | 3 3
R | 12 113334
V | 11 44
I 50 + 2 2 3344
V | 11 4 4
A | 222 1113
L | 3 3
40 + 2 2 11
| 1 1
| 2 2
|
30 + 2 2
| 22
|
| 2 2
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 40 obs hidden.
2-BUTOXYETHANOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
31.2 PPM = 2
62.5 PPM = 3
125 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 4 2
| 3 3 1 4 4 2 1 2
| 3 3 4 1 12212
| 3 3 4 4
P 90 + 3 3 12412 4
E | 3 3 12 1 2
R | 3 3 1 221
C | 3 3 14 1
E 80 + 4 112
N | 3 3 411
T | 3 3 3 41 42 1
| 3 3
S 70 + 2 1 1
U | 33 44
R | 3 3 42 211
V | 44 22
I 60 + 211
V | 33 1 1
A | 433 2 2
L | 33
50 + 443 3
|
| 4 3 3
| 4
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 30 obs hidden.