Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/6793

TDMS Study 05197-12 Pathology Tables

NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10

                                                      FINAL#1, REVISION #1




       Facility:  Battelle Northwest

       Chemical CAS #:  111-76-0002

       Lock Date:  11/08/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            3            5            4                                     
    Moribund Sacrifice                                14           16           12           10                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           31           33           36                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (49)         (50)         (50)                                   
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (50)         (48)         (50)                                   
      Inflammation                                                               1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Large, Cecum                             (49)         (50)         (47)         (48)                                   
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Intestine Small, Duodenum                          (45)         (49)         (47)         (47)                                   
      Inflammation                                                  2 (4%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Epithelium, Hyperplasia                          1 (2%)       2 (4%)                    2 (4%)                                
   Intestine Small, Jejunum                           (46)         (49)         (47)         (48)                                   
      Inflammation                                                                            1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Intestine Small, Ileum                             (46)         (50)         (47)         (48)                                   
      Peyer's Patch, Hyperplasia                                                              1 (2%)                                
   Liver                                              (50)         (50)         (49)         (50)                                   
      Angiectasis                                                   1 (2%)                    2 (4%)                                
      Basophilic Focus                                 1 (2%)                                 1 (2%)                                
      Clear Cell Focus                                 2 (4%)       1 (2%)                    1 (2%)                                
      Degeneration, Fatty                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Eosinophilic Focus                              10 (20%)      6 (12%)     10 (20%)      5 (10%)                               
      Hematopoietic Cell Proliferation                 5 (10%)      7 (14%)      1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infarct                                                                    1 (2%)                                             
      Inflammation                                     3 (6%)       5 (10%)      4 (8%)       4 (8%)                                
      Necrosis                                         2 (4%)       8 (16%)      7 (14%)      3 (6%)                                
      Thrombosis                                                                 1 (2%)                                             
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Endothelial Cell, Hyperplasia                                              1 (2%)                                             
      Kupffer Cell, Pigmentation, Hemosiderin                       5 (10%)     25 (51%)     44 (88%)                               
   Mesentery                                          (10)         (4)          (5)          (9)                                    
      Fat, Necrosis                                    7 (70%)      3 (75%)      4 (80%)      9 (100%)                              

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (49)         (50)         (49)         (50)                                   
      Atrophy                                          6 (12%)      4 (8%)       2 (4%)       8 (16%)                               
      Cytoplasmic Alteration                           1 (2%)       2 (4%)                    2 (4%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation                                                               3 (6%)                                             
      Duct, Cyst                                                    1 (2%)                    1 (2%)                                
      Duct, Inflammation                                            1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Erosion                                          1 (2%)                                                                       
      Ulcer                                            1 (2%)       7 (14%)     13 (27%)     22 (44%)                               
      Epithelium, Hyperplasia                          6 (12%)     27 (54%)     42 (86%)     44 (88%)                               
   Stomach, Glandular                                 (48)         (50)         (49)         (49)                                   
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Epithelium, Hyperplasia                          1 (2%)                    1 (2%)       1 (2%)                                
   Tongue                                             (1)                                    (1)                                    
      Epithelium, Hyperplasia                                                                 1 (100%)                              
   Tooth                                                           (1)                                                              
      Inflammation                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                       (2)                                    
      Inflammation                                                                            1 (50%)                               
      Mineralization                                                1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  46 (92%)     45 (90%)     44 (88%)     45 (90%)                               
      Mineralization                                                1 (2%)                                                          
      Artery, Inflammation                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Degeneration, Cystic                                                                    2 (4%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Hypertrophy                                      3 (6%)       2 (4%)       6 (12%)      5 (10%)                               
      Capsule, Hyperplasia                                                       1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 (2%)       3 (6%)       3 (6%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (50)         (49)         (48)         (49)                                   
      Pars Distalis, Angiectasis                       1 (2%)       4 (8%)                                                          
      Pars Distalis, Hyperplasia                      15 (30%)     15 (31%)     16 (33%)     20 (41%)                               
      Pars Intermedia, Hyperplasia                     1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Inflammation                                                  1 (2%)                                                          
      Follicle, Cyst                                                                          1 (2%)                                
      Follicular Cell, Hyperplasia                    11 (22%)      8 (16%)     11 (22%)     11 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (49)         (49)                                   
      Angiectasis                                      2 (4%)                    2 (4%)       1 (2%)                                
      Atrophy                                          1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Cyst                                            11 (22%)     12 (24%)     19 (39%)     16 (33%)                               
      Degeneration, Fatty                                                                     1 (2%)                                
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Thrombosis                                       1 (2%)                    2 (4%)                                             
      Corpus Luteum, Hyperplasia                                                              1 (2%)                                
      Germinal Epithelium, Hyperplasia                              1 (2%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Adenomyosis                                                                             1 (2%)                                
      Angiectasis                                      2 (4%)       3 (6%)       1 (2%)                                             
      Hydrometra                                       2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
      Hyperplasia, Cystic                              2 (4%)                    2 (4%)       6 (12%)                               
      Inflammation                                     1 (2%)                                                                       
      Lymphangiectasis                                                           1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Arteriole, Hyperplasia                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia                                      2 (4%)       4 (8%)       2 (4%)       3 (6%)                                
      Hyperplasia, Megakaryocyte                                                              1 (2%)                                
   Lymph Node                                         (4)          (7)          (6)          (1)                                    
      Angiectasis                                      1 (25%)      1 (14%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                      1 (25%)                                                                      
      Iliac, Hyperplasia                               1 (25%)                                                                      
      Pancreatic, Hyperplasia                                       1 (14%)                                                         
   Lymph Node, Bronchial                              (41)         (39)         (41)         (37)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       6 (15%)      4 (10%)                                            
      Hyperplasia, Histiocytic                                                                1 (3%)                                
   Lymph Node, Mandibular                             (37)         (38)         (40)         (38)                                   
      Hyperplasia                                      1 (3%)       2 (5%)       2 (5%)       1 (3%)                                
   Lymph Node, Mesenteric                             (47)         (48)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      1 (2%)       2 (4%)       3 (6%)       3 (6%)                                
   Lymph Node, Mediastinal                            (31)         (40)         (38)         (34)                                   
      Hyperplasia                                      2 (6%)       2 (5%)       5 (13%)                                            
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
   Spleen                                             (50)         (50)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                24 (48%)     29 (58%)     32 (65%)     35 (70%)                               
      Hyperplasia, Lymphoid                            6 (12%)     15 (30%)     12 (24%)     10 (20%)                               
      Pigmentation, Hemosiderin                       39 (78%)     44 (88%)     46 (94%)     48 (96%)                               
   Thymus                                             (46)         (41)         (46)         (48)                                   
      Atrophy                                          1 (2%)       2 (5%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       2 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                                      1 (2%)                                                          
      Pinna, Inflammation, Chronic                     1 (2%)                                                                       
      Subcutaneous Tissue, Edema                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Arthrosis                                                                               1 (2%)                                
      Fibrous Osteodystrophy                          22 (44%)     28 (56%)     25 (50%)     21 (42%)                               
      Maxilla, Fracture                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         2 (4%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                        1 (2%)       3 (6%)                    1 (2%)                                
      Squamous Epithelium, Hyperplasia                 2 (4%)       8 (16%)      3 (6%)       5 (10%)                               
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                      10 (20%)      2 (4%)       6 (12%)      6 (12%)                               
      Infiltration Cellular, Histiocyte                3 (6%)       2 (4%)       3 (6%)       2 (4%)                                
      Inflammation                                                  1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)                    2 (4%)                                
      Mediastinum, Inflammation                                     1 (2%)                                                          
      Perivascular, Inflammation                       2 (4%)                                                                       
   Nose                                               (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)       3 (6%)       1 (2%)                                             
      Olfactory Epithelium, Atrophy                    2 (4%)       4 (8%)       2 (4%)       4 (8%)                                
      Olfactory Epithelium, Degeneration, Hyaline      6 (12%)     14 (28%)     11 (22%)     12 (24%)                               
      Olfactory Epithelium, Metaplasia                 1 (2%)       1 (2%)                                                          
      Respiratory Epithelium, Degeneration, Hyaline   17 (34%)     35 (70%)     26 (53%)     23 (46%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                    (4)                                    
      Degeneration                                                                            1 (25%)                               
      Cornea, Inflammation, Chronic                    1 (100%)                               3 (75%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Glomerulosclerosis                               7 (14%)      2 (4%)       8 (16%)      8 (16%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)       1 (2%)       3 (6%)       4 (8%)                                
      Nephropathy                                     34 (68%)     39 (78%)     38 (78%)     33 (66%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Pigmentation, Hemosiderin                        1 (2%)       1 (2%)                                                          
      Renal Tubule, Degeneration                                                 1 (2%)                                             
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Mineralization                                  1 (2%)                                                          
   Urinary Bladder                                    (47)         (49)         (48)         (50)                                   
      Inflammation                                     1 (2%)       1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            8           13           10                                     
    Natural Death                                      4            3           10           14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           39           27           26                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (45)         (40)         (35)                                   
      Degeneration, Hyaline                                         1 (2%)                                                          
      Inflammation                                                  1 (2%)                                                          
   Intestine Small, Duodenum                          (49)         (48)         (44)         (41)                                   
      Inflammation                                                                            1 (2%)                                
      Epithelium, Hyperplasia                                                                 1 (2%)                                
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Intestine Small, Jejunum                           (48)         (47)         (43)         (38)                                   
      Peyer's Patch, Hyperplasia                       1 (2%)                                 1 (3%)                                
   Intestine Small, Ileum                             (48)         (47)         (43)         (39)                                   
      Inflammation                                     1 (2%)                                                                       
      Peyer's Patch, Hyperplasia                       1 (2%)       1 (2%)                                                          
   Liver                                              (50)         (50)         (49)         (49)                                   
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                                           1 (2%)       3 (6%)                                
      Clear Cell Focus                                 4 (8%)                    5 (10%)      3 (6%)                                
      Degeneration, Fatty                              1 (2%)       2 (4%)       4 (8%)                                             
      Eosinophilic Focus                              14 (28%)     10 (20%)     18 (37%)     12 (24%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation                                     6 (12%)      3 (6%)       6 (12%)      6 (12%)                               
      Karyomegaly                                      2 (4%)                                 1 (2%)                                
      Necrosis                                         6 (12%)      2 (4%)       7 (14%)      9 (18%)                               
      Bile Duct, Cyst                                                            1 (2%)       1 (2%)                                
      Kupffer Cell, Pigmentation, Hemosiderin                                    8 (16%)     30 (61%)                               
      Oval Cell, Hyperplasia                           1 (2%)       1 (2%)       2 (4%)       3 (6%)                                
   Mesentery                                          (5)          (3)          (3)          (1)                                    
      Angiectasis                                                   1 (33%)                                                         
      Fat, Necrosis                                    5 (100%)     2 (67%)      2 (67%)                                            
   Pancreas                                           (50)         (50)         (47)         (47)                                   
      Atrophy                                         10 (20%)      4 (8%)       2 (4%)       4 (9%)                                
      Cytoplasmic Alteration                           1 (2%)                                 1 (2%)                                
      Degeneration, Hyaline                                         1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation                                                  1 (2%)                                                          
      Duct, Cyst                                                    1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (48)         (50)                                   
      Inflammation                                                  1 (2%)       1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (49)         (48)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            1 (2%)       2 (4%)       9 (18%)      3 (6%)                                
      Epithelium, Hyperplasia                          1 (2%)       7 (14%)     16 (33%)     21 (44%)                               
   Stomach, Glandular                                 (50)         (50)         (46)         (47)                                   
      Degeneration, Hyaline                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Ulcer                                                         1 (2%)       2 (4%)                                             
      Epithelium, Hyperplasia                                                    4 (9%)       1 (2%)                                
   Tooth                                                           (4)                                                              
      Malformation                                                  4 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  47 (94%)     48 (96%)     47 (94%)     47 (94%)                               
      Artery, Inflammation                             1 (2%)                                                                       
      Atrium, Thrombosis                               1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Degeneration, Cystic                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hyperplasia                                      5 (10%)      9 (18%)      9 (18%)      9 (18%)                               
      Hypertrophy                                     38 (76%)     28 (56%)     27 (55%)     27 (54%)                               
      Capsule, Hyperplasia                             2 (4%)                                 3 (6%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (49)                                   
      Hyperplasia                                      1 (2%)       2 (4%)                    3 (6%)                                
   Islets, Pancreatic                                 (50)         (50)         (47)         (46)                                   
      Hyperplasia                                      6 (12%)      3 (6%)       2 (4%)                                             
      Inflammation                                     1 (2%)                                                                       
   Parathyroid Gland                                  (26)         (29)         (26)         (31)                                   
      Cyst                                                          1 (3%)                                                          
   Pituitary Gland                                    (49)         (49)         (46)         (48)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       5 (10%)      1 (2%)       2 (4%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (50)         (48)         (49)         (50)                                   
      Follicular Cell, Hyperplasia                     5 (10%)      8 (17%)      6 (12%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
      Granuloma Sperm                                               1 (2%)                                                          
      Hyperplasia                                                                             1 (2%)                                
      Inflammation                                     4 (8%)       4 (8%)       1 (2%)       4 (8%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
   Penis                                                                        (1)                                                 
      Inflammation                                                               1 (100%)                                           
   Preputial Gland                                    (49)         (49)         (49)         (49)                                   
      Ectasia                                          1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation                                     2 (4%)       7 (14%)      6 (12%)      8 (16%)                               
   Prostate                                           (49)         (49)         (48)         (45)                                   
      Inflammation                                                  2 (4%)       3 (6%)       4 (9%)                                
      Epithelium, Hyperplasia                                                    1 (2%)       1 (2%)                                
   Seminal Vesicle                                    (50)         (49)         (46)         (46)                                   
      Inflammation                                     1 (2%)                    2 (4%)       3 (7%)                                
   Testes                                             (50)         (50)         (49)         (50)                                   
      Atrophy                                          5 (10%)      4 (8%)       6 (12%)      4 (8%)                                
      Mineralization                                                             3 (6%)                                             
      Interstitial Cell, Hyperplasia                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                                   1 (2%)       9 (18%)      5 (10%)                               
      Thrombosis                                                                              1 (2%)                                
   Lymph Node                                         (2)          (1)                       (1)                                    
      Renal, Hyperplasia                                                                      1 (100%)                              
   Lymph Node, Bronchial                              (38)         (35)         (33)         (35)                                   
      Hyperplasia                                      2 (5%)                    1 (3%)                                             
   Lymph Node, Mandibular                             (24)         (26)         (32)         (25)                                   
      Hyperplasia                                                   1 (4%)       1 (3%)       1 (4%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (47)         (43)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                      2 (4%)       2 (4%)                    1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                 1 (2%)       3 (6%)       1 (2%)                                             
      Hyperplasia                                      7 (14%)      7 (14%)      4 (9%)       4 (9%)                                
   Spleen                                             (50)         (50)         (48)         (49)                                   
      Hematopoietic Cell Proliferation                12 (24%)     11 (22%)     26 (54%)     42 (86%)                               
      Hyperplasia, Lymphoid                            5 (10%)      8 (16%)      3 (6%)       1 (2%)                                
      Pigmentation, Hemosiderin                                     6 (12%)     45 (94%)     44 (90%)                               
   Thymus                                             (43)         (43)         (36)         (37)                                   
      Atrophy                                          1 (2%)       1 (2%)       1 (3%)       1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)                                   
      Granuloma                                                                  1 (2%)                                             
      Inflammation                                                  1 (2%)                                                          
      Pigmentation, Melanin                                                      1 (2%)                                             
      Prepuce, Hyperplasia                                                       1 (2%)       2 (4%)                                
      Prepuce, Inflammation, Chronic Active            2 (4%)       3 (6%)      13 (27%)      8 (16%)                               
      Prepuce, Ulcer                                                3 (6%)      11 (22%)      8 (16%)                               
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           1 (2%)       4 (8%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                                                  1 (2%)       1 (2%)                                
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (48)         (49)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Squamous Epithelium, Hyperplasia                              3 (6%)                                                          
   Lung                                               (50)         (50)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)                                
      Hemorrhage                                       5 (10%)      5 (10%)      5 (10%)      3 (6%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Infiltration Cellular, Histiocyte                6 (12%)      1 (2%)       4 (8%)       4 (8%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 6 (12%)      1 (2%)       2 (4%)       4 (8%)                                
      Artery, Inflammation                                                                    1 (2%)                                
   Nose                                               (50)         (50)         (48)         (48)                                   
      Inflammation, Suppurative                        2 (4%)       6 (12%)      2 (4%)       2 (4%)                                
      Polyp, Inflammatory                                           1 (2%)       1 (2%)                                             
      Glands, Hyperplasia                                                                     1 (2%)                                
      Olfactory Epithelium, Atrophy                    4 (8%)       4 (8%)       3 (6%)                                             
      Olfactory Epithelium, Degeneration, Hyaline      1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Respiratory Epithelium, Degeneration, Hyaline    4 (8%)      10 (20%)      5 (10%)      5 (10%)                               
      Respiratory Epithelium, Metaplasia, Squamous                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Inflammation, Granulomatous                      1 (100%)                                                                     
   Eye                                                (1)                       (1)                                                 
      Cornea, Inflammation, Chronic                                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (47)         (50)                                   
      Glomerulosclerosis                               4 (8%)       4 (8%)      11 (23%)      9 (18%)                               
      Hydronephrosis                                   1 (2%)                    6 (13%)      5 (10%)                               
      Inflammation                                                                            1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)       4 (8%)                                
      Metaplasia, Osseous                                           2 (4%)                                                          
      Mineralization                                   1 (2%)                                 2 (4%)                                
      Nephropathy                                     48 (96%)     45 (90%)     40 (85%)     37 (74%)                               
      Capsule, Inflammation                                                                   1 (2%)                                
      Cortex, Cyst                                     4 (8%)       1 (2%)                    6 (12%)                               
      Pelvis, Inflammation, Chronic Active                          1 (2%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                        2 (4%)       2 (4%)       1 (2%)                                             
      Renal Tubule, Mineralization                     4 (8%)       2 (4%)       3 (6%)       2 (4%)                                
      Renal Tubule, Necrosis                           1 (2%)                    1 (2%)                                             
      Renal Tubule, Pigmentation                                                              3 (6%)                                
   Urinary Bladder                                    (50)         (50)         (46)         (45)                                   
      Inflammation                                                  2 (4%)       5 (11%)      4 (9%)                                
      Transitional Epithelium, Hyperplasia                          2 (4%)       1 (2%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Ulcer                                1 (2%)       4 (9%)       2 (4%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------