TDMS Study 05197-12 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest 2-BUTOXYETHANOL DATE: 08/23/99
EXPERIMENT: 05197 TEST: 12 TIME: 11:23:21
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-15318 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 62077D
PATHOLOGIST: MILLER, RODNEY CAS: 111-76-0002
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1, REVISION #1
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest 2-BUTOXYETHANOL DATE: 08/23/99
EXPERIMENT: 05197 TEST: 12 TIME: 11:23:21
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15318 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 62077D
PATHOLOGIST: MILLER, RODNEY CAS: 111-76-0002
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 374 459 556 561 565 618 621 642 663 667 |
| 669 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 62.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 549 611 621 649 656 670 681 681 701 705 |
| 707 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 421 430 457 502 511 537 563 567 582 583 |
| 583 585 597 600 618 647 655 663 670 681 |
| 698 704 705 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 73 312 368 374 402 442 454 596 604 613 |
| 614 623 629 638 663 665 670 670 684 684 |
| 694 694 702 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 90.0 82.0 78.0 |
| | |
| | |
|62.5 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 90.0 78.0 |
| | |
| | |
|125 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 88.0 72.0 64.0 54.0 |
| | |
| | |
|250 PPM | 98.0 98.0 98.0 96.0 90.0 86.0 86.0 82.0 68.0 52.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 62.5 PPM 125 PPM 250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 78.0% 54.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.001 P=1.000N P=0.021 P=0.015 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 581.4 657.4 589.5 565.8 |
|NATURAL DEATHS (C) | (28.2) (14.5) (17.6) (32.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 696.5 713.2 664.8 650.7 |
|(STANDARD ERROR) | (10.6) ( 5.2) (12.7) (19.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 1 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 376 521 561 565 572 577 586 590 606 611 |
| 621 645 649 689 700 713 715 715 721 730 |
| CENSORED DEATHS |
| 725 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 62.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 255 369 372 456 472 534 544 592 604 606 |
| 647 670 672 676 694 712 712 715 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 72 196 397 408 456 537 544 570 572 591 |
| 627 666 698 715 723 723 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 437 485 489 529 582 582 618 621 653 656 |
| 656 660 682 708 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2-BUTOXYETHANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 98.0 96.0 84.0 74.0 59.9 |
| | |
| | |
|62.5 PPM | 100.0 100.0 98.0 98.0 94.0 90.0 86.0 82.0 78.0 62.0 |
| | |
| | |
|125 PPM | 98.0 98.0 96.0 96.0 92.0 90.0 86.0 80.0 78.0 66.0 |
| | |
| | |
|250 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 92.0 88.0 76.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 62.5 PPM 125 PPM 250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 59.9% 62.0% 66.0% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.254N P=1.000N P=0.741N P=0.324N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 623.2 580.3 542.2 597.0 |
|NATURAL DEATHS (C) | (19.5) (31.6) (45.6) (22.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 687.7 673.7 666.8 693.5 |
|(STANDARD ERROR) | (10.7) (15.8) (19.9) (10.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2-BUTOXYETHANOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
62.5 PPM = 2
125 PPM = 3
250 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 4 1 3 2
| 4 4 1 33 1 2 2
96 + 4 4 3 1 1 22
| 44 3 3 11 2 2
P | 4 4 33 22
E | 4 4 3 3 1 1 2 2
R 88 + 4 4 3 3 2 2
C | 4 4 1 1
E | 3 3 44 1 1 2 2
N | 44 11
T 80 +
| 44 1 2 1
S | 3 3 44
U | 4 4
R 72 + 3 3 4 4
V | 3 3
I | 33 44
V | 3 3
A 64 + 33 4
L | 3 3
| 3 3
| 33
56 + 44
| 34 3
| 4 4
|
48 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
2-BUTOXYETHANOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
62.5 PPM = 2
125 PPM = 3
250 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1 4
|
| 3 3 2 21 4 4 1
| 3 22 3 1 1
95 +
| 2 3 3 2 4 4
| 3 2 2 4 11 4
|
P 90 + 3 2 2 11
E |
R | 22 11 4
C | 2 3 1 1
E 85 +
N | 1 1 4 4
T | 3 3 11
|
S 80 + 3 2113 2
U |
R | 13 14 42
V | 43 4 3
I 75 +
V | 1 22413 43
A | 2 11 433 4
L |
70 + 1 1
|
| 11
| 223 3
65 +
| 22
| 12 1
|
60 + 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.