TDMS Study 05200-06 Pathology Tables
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 Facility: Battelle Northwest Chemical CAS #: 75-52-5 Lock Date: 06/22/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Natural Death 7 5 3 2 Moribund Sacrifice 16 17 20 12 Accidently Killed 2 1 Survivors Terminal Sacrifice 25 27 26 36 Moribund Sacrifice 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (48) (48) (49) (49) Epithelium, Hyperplasia 1 (2%) 1 (2%) Gallbladder (40) (45) (45) (46) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) Intestine Large, Cecum (49) (46) (47) (50) Diverticulum 1 (2%) Muscularis, Hyperplasia 1 (2%) Intestine Small, Duodenum (48) (43) (45) (49) Cyst 1 (2%) Peyer's Patch, Hyperplasia 1 (2%) Intestine Small, Jejunum (47) (45) (47) (48) Epithelium, Hyperplasia 1 (2%) Liver (50) (49) (49) (50) Angiectasis 1 (2%) Basophilic Focus 1 (2%) 1 (2%) Eosinophilic Focus 4 (8%) 7 (14%) 11 (22%) 15 (30%) Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 2 (4%) 2 (4%) Inflammation, Chronic 1 (2%) 3 (6%) 1 (2%) Mixed Cell Focus 2 (4%) 1 (2%) 1 (2%) Necrosis 2 (4%) 2 (4%) 3 (6%) Vacuolization Cytoplasmic 1 (2%) Bile Duct, Cyst 1 (2%) Centrilobular, Degeneration, Fatty 1 (2%) 1 (2%) Centrilobular, Necrosis 1 (2%) 3 (6%) Mesentery (7) (14) (8) (11) Hemorrhage 1 (7%) Inflammation, Suppurative 1 (13%) Fat, Hemorrhage 1 (13%) Fat, Necrosis 6 (86%) 11 (79%) 5 (63%) 10 (91%) Fat, Thrombosis 1 (7%) Pancreas (50) (48) (48) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Atrophy 2 (4%) 2 (4%) 1 (2%) 2 (4%) Basophilic Focus 2 (4%) 1 (2%) 1 (2%) 1 (2%) Necrosis 1 (2%) Duct, Cyst 1 (2%) 2 (4%) Duct, Inflammation, Suppurative 1 (2%) Salivary Glands (49) (48) (49) (50) Atrophy 1 (2%) Stomach, Forestomach (50) (48) (49) (50) Angiectasis 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) Ulcer 3 (6%) 1 (2%) Epithelium, Hyperplasia 1 (2%) 4 (8%) 3 (6%) 1 (2%) Stomach, Glandular (49) (48) (48) (50) Degeneration, Hyaline 1 (2%) Inflammation 1 (2%) 1 (2%) Ulcer 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) (2) Aorta, Mineralization 1 (100%) 1 (50%) Heart (50) (50) (50) (50) Cardiomyopathy 13 (26%) 23 (46%) 19 (38%) 18 (36%) Mineralization 1 (2%) Thrombosis 1 (2%) Artery, Inflammation 1 (2%) Endothelium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (48) (49) (50) Degeneration, Cystic 1 (2%) 3 (6%) Hyperplasia 1 (2%) 2 (4%) Hypertrophy 2 (4%) 4 (8%) 5 (10%) 3 (6%) Capsule, Hyperplasia 2 (4%) 2 (4%) Adrenal Medulla (50) (48) (49) (49) Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%) Islets, Pancreatic (50) (48) (47) (50) Hyperplasia 1 (2%) 1 (2%) Parathyroid Gland (33) (34) (33) (34) Cyst 1 (3%) Pituitary Gland (50) (46) (48) (50) Pars Distalis, Angiectasis 1 (2%) Pars Distalis, Hyperplasia 11 (22%) 20 (43%) 11 (23%) 18 (36%) Pars Intermedia, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Intermedia, Hypertrophy 1 (2%) Thyroid Gland (50) (48) (48) (50) Follicular Cell, Hyperplasia 5 (10%) 4 (8%) 3 (6%) 5 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (47) (47) (48) (48) Angiectasis 4 (9%) 2 (4%) 1 (2%) Atrophy 14 (30%) 16 (34%) 14 (29%) 13 (27%) Cyst 13 (28%) 14 (30%) 16 (33%) 13 (27%) Hyperplasia, Tubular 3 (6%) 2 (4%) 2 (4%) Thrombosis 1 (2%) 1 (2%) Bilateral, Cyst 1 (2%) Granulosa Cell, Hyperplasia 1 (2%) Interstitial Cell, Hyperplasia 1 (2%) Uterus (50) (49) (49) (50) Adenomyosis 1 (2%) Angiectasis 2 (4%) 2 (4%) 4 (8%) Hemorrhage 1 (2%) Hydrometra 3 (6%) 4 (8%) 5 (10%) 10 (20%) Hyperplasia, Cystic 4 (8%) 6 (12%) 3 (6%) 2 (4%) Inflammation, Suppurative 1 (2%) Thrombosis 1 (2%) 2 (4%) Myometrium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (48) (49) (50) Hyperplasia 3 (6%) Infiltration Cellular, Mast Cell 1 (2%) Lymph Node (8) (6) (5) (6) Ectasia 1 (13%) Hyperplasia 1 (20%) Iliac, Hematopoietic Cell Proliferation 1 (20%) Iliac, Hyperplasia 2 (33%) 1 (17%) Pancreatic, Hyperplasia 1 (17%) Renal, Hematopoietic Cell Proliferation 1 (20%) Renal, Hyperplasia 2 (33%) 1 (20%) 2 (33%) Lymph Node, Bronchial (39) (36) (40) (40) Hyperplasia 4 (10%) 5 (14%) 3 (8%) 2 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Lymph Node, Mandibular (43) (34) (38) (43) Hematopoietic Cell Proliferation 1 (3%) Hyperplasia 1 (2%) 1 (3%) 5 (13%) 5 (12%) Lymph Node, Mesenteric (48) (46) (46) (48) Angiectasis 1 (2%) 1 (2%) 2 (4%) Congestion 1 (2%) 1 (2%) Hyperplasia 6 (13%) 9 (20%) 3 (7%) 4 (8%) Infiltration Cellular, Mast Cell 1 (2%) Lymph Node, Mediastinal (38) (37) (35) (41) Hyperplasia 6 (16%) 5 (14%) 3 (9%) 2 (5%) Spleen (50) (48) (49) (50) Angiectasis 1 (2%) Hematopoietic Cell Proliferation 10 (20%) 13 (27%) 10 (20%) 12 (24%) Hyperplasia, Lymphoid 5 (10%) 10 (21%) 6 (12%) 8 (16%) Infiltration Cellular, Mast Cell 1 (2%) Thymus (43) (39) (41) (47) Atrophy 1 (2%) 2 (5%) 2 (5%) Hyperplasia, Lymphoid 3 (7%) 2 (5%) 6 (15%) 5 (11%) Infiltration Cellular, Mast Cell 1 (2%) Necrosis 1 (3%) 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (48) (49) (50) Hyperplasia 2 (4%) Skin (49) (47) (50) (50) Cyst Epithelial Inclusion 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Arthrosis 1 (2%) Fibrous Osteodystrophy 17 (34%) 18 (36%) 18 (36%) 12 (24%) Hyperostosis 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (49) (50) Meninges, Infiltration Cellular, Mononuclear Cell 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (49) (48) (49) (50) Inflammation, Suppurative 1 (2%) Metaplasia, Squamous 1 (2%) Lung (50) (50) (49) (50) Hemorrhage 1 (2%) 1 (2%) 1 (2%) 2 (4%) Infiltration Cellular, Histiocyte 1 (2%) 6 (12%) 4 (8%) Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%) Pigmentation, Hemosiderin 2 (4%) 1 (2%) Alveolar Epithelium, Hyperplasia 3 (6%) 1 (2%) 5 (10%) 1 (2%) Bronchus, Infiltration Cellular, Mixed Cell 1 (2%) Mediastinum, Hemorrhage, Focal 1 (2%) Mediastinum, Infiltration Cellular, Mast Cell 1 (2%) Mediastinum, Inflammation, Chronic 1 (2%) Mediastinum, Necrosis 1 (2%) Perivascular, Inflammation, Chronic 1 (2%) 1 (2%) Nose (50) (49) (50) (50) Inflammation, Chronic, Focal 1 (2%) Inflammation, Suppurative 2 (4%) 4 (8%) 1 (2%) Glands, Hyperplasia 1 (2%) Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 3 (6%) 3 (6%) Olfactory Epithelium, Atrophy, Focal 2 (4%) 6 (12%) Olfactory Epithelium, Degeneration 22 (45%) 50 (100%) 50 (100%) Olfactory Epithelium, Metaplasia 2 (4%) 46 (92%) 48 (96%) Respiratory Epithelium, Degeneration, Hyaline 16 (32%) 39 (80%) 50 (100%) 50 (100%) Respiratory Epithelium, Metaplasia, Squamous 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (1) Inflammation 1 (100%) 1 (100%) Harderian Gland (49) (49) (50) (50) Fibrosis, Focal 1 (2%) Hyperplasia 3 (6%) 2 (4%) 5 (10%) 1 (2%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (48) (49) (50) Amyloid Deposition 1 (2%) Hydronephrosis 1 (2%) Metaplasia, Osseous 1 (2%) 2 (4%) 3 (6%) 1 (2%) Nephropathy 12 (24%) 5 (10%) 7 (14%) 7 (14%) Renal Tubule, Degeneration 1 (2%) Renal Tubule, Mineralization 1 (2%) 1 (2%) Urinary Bladder (49) (47) (47) (49) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Inflammation, Suppurative 1 (2%) 2 (4%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 14 11 16 16 Natural Death 5 3 4 5 Survivors Terminal Sacrifice 31 36 30 29 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (43) (47) (43) (42) Degeneration, Hyaline 1 (2%) Hyperplasia 1 (2%) Intestine Large, Cecum (46) (48) (47) (46) Hemorrhage 1 (2%) Intestine Small, Jejunum (45) (49) (47) (46) Peyer's Patch, Hyperplasia 1 (2%) Liver (50) (50) (50) (50) Basophilic Focus 1 (2%) 3 (6%) 1 (2%) Clear Cell Focus 2 (4%) 2 (4%) 2 (4%) 8 (16%) Eosinophilic Focus 11 (22%) 8 (16%) 9 (18%) 11 (22%) Hematopoietic Cell Proliferation 2 (4%) Inflammation, Chronic 2 (4%) 1 (2%) Mixed Cell Focus 1 (2%) Necrosis 4 (8%) 3 (6%) 3 (6%) 2 (4%) Bile Duct, Cyst 1 (2%) 1 (2%) Bile Duct, Degeneration 1 (2%) Mesentery (3) (6) (2) Fat, Inflammation, Chronic 1 (17%) Fat, Necrosis 3 (100%) 3 (50%) 2 (100%) Pancreas (49) (50) (49) (49) Angiectasis 1 (2%) Atrophy 2 (4%) Basophilic Focus 1 (2%) Cytoplasmic Alteration 1 (2%) Duct, Cyst 1 (2%) 1 (2%) Stomach, Forestomach (49) (50) (50) (48) Inflammation, Suppurative 1 (2%) Epithelium, Hyperplasia 4 (8%) 1 (2%) Stomach, Glandular (48) (48) (48) (48) Inflammation 1 (2%) Ulcer 1 (2%) 2 (4%) Tooth (3) (3) (1) Developmental Malformation 2 (67%) 2 (67%) 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Dysplasia 1 (33%) Infiltration Cellular, Mast Cell 1 (33%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cardiomyopathy 20 (40%) 20 (40%) 20 (40%) 19 (38%) Mineralization 1 (2%) Artery, Thrombosis 1 (2%) Atrium, Thrombosis 1 (2%) Endothelium, Hyperplasia 2 (4%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (50) (49) (48) Degeneration 1 (2%) Degeneration, Cystic 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 1 (2%) Hyperplasia 4 (8%) 4 (8%) 6 (12%) 6 (13%) Hypertrophy 22 (45%) 22 (44%) 19 (39%) 22 (46%) Capsule, Hyperplasia 2 (4%) 2 (4%) Adrenal Medulla (49) (50) (49) (47) Hyperplasia 1 (2%) 1 (2%) 1 (2%) Islets, Pancreatic (49) (50) (49) (49) Hyperplasia 5 (10%) 4 (8%) 3 (6%) 4 (8%) Parathyroid Gland (41) (34) (38) (37) Cyst 1 (3%) Pituitary Gland (47) (50) (46) (47) Pars Intermedia, Hyperplasia 1 (2%) Thyroid Gland (50) (50) (49) (48) Follicular Cell, Hyperplasia 9 (18%) 3 (6%) 2 (4%) 4 (8%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (49) Granuloma Sperm 1 (2%) 1 (2%) 1 (2%) Inflammation, Suppurative 1 (2%) Penis (1) (2) (3) (1) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Inflammation, Suppurative 1 (100%) 2 (100%) 1 (33%) 1 (100%) Preputial Gland (49) (50) (49) (48) Cyst 5 (10%) 3 (6%) 2 (4%) 4 (8%) Inflammation, Chronic 4 (8%) 3 (6%) 5 (10%) 4 (8%) Inflammation, Suppurative 1 (2%) Bilateral, Cyst 1 (2%) Prostate (49) (50) (47) (46) Hyperplasia 1 (2%) Inflammation, Suppurative 2 (4%) 1 (2%) 2 (4%) Seminal Vesicle (49) (49) (49) (47) Hyperplasia 1 (2%) Inflammation 1 (2%) Testes (50) (50) (50) (50) Atrophy 4 (8%) 2 (4%) 4 (8%) 4 (8%) Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) (50) Angiectasis 1 (2%) Hyperplasia 1 (2%) 2 (4%) 4 (8%) 1 (2%) Lymph Node (3) (1) (1) (2) Iliac, Hyperplasia 1 (33%) 2 (100%) Renal, Hyperplasia 1 (100%) Lymph Node, Bronchial (26) (26) (24) (28) Hyperplasia 1 (4%) 1 (4%) 1 (4%) Lymph Node, Mandibular (40) (39) (37) (43) Hyperplasia 2 (5%) 1 (3%) 1 (3%) 4 (9%) Lymph Node, Mesenteric (47) (46) (47) (49) Angiectasis 3 (6%) 2 (4%) Congestion 1 (2%) Hyperplasia 3 (6%) 7 (15%) 2 (4%) 5 (10%) Lymph Node, Mediastinal (35) (37) (36) (40) Hyperplasia 2 (6%) 1 (3%) 1 (3%) Spleen (49) (50) (50) (49) Angiectasis 1 (2%) 1 (2%) Fibrosis 1 (2%) Fibrosis, Focal 1 (2%) Hematopoietic Cell Proliferation 8 (16%) 9 (18%) 11 (22%) 7 (14%) Hyperplasia, Lymphoid 2 (4%) Thymus (33) (34) (33) (40) Necrosis 1 (3%) 1 (3%) 1 (3%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (49) (49) (49) (48) Inflammation, Suppurative 5 (10%) 1 (2%) 2 (4%) Prepuce, Inflammation, Suppurative 6 (12%) 3 (6%) 8 (16%) 3 (6%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Hyperostosis 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) (49) (48) Inflammation, Suppurative 1 (2%) 1 (2%) Lung (50) (50) (50) (50) Hemorrhage 1 (2%) 1 (2%) Infiltration Cellular, Histiocyte 7 (14%) 2 (4%) 3 (6%) 6 (12%) Inflammation, Chronic 1 (2%) Pigmentation, Hemosiderin 1 (2%) 3 (6%) Thrombosis 1 (2%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 3 (6%) 1 (2%) Mediastinum, Inflammation, Chronic 1 (2%) Perivascular, Inflammation, Chronic 2 (4%) Nose (50) (49) (50) (50) Inflammation, Suppurative 1 (2%) 5 (10%) 3 (6%) 1 (2%) Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 3 (6%) 10 (20%) 10 (20%) Olfactory Epithelium, Atrophy, Focal 3 (6%) 8 (16%) Olfactory Epithelium, Degeneration 10 (20%) 50 (100%) 50 (100%) Olfactory Epithelium, Metaplasia 1 (2%) 41 (82%) 49 (98%) Respiratory Epithelium, Degeneration, Hyaline 5 (10%) 5 (10%) 50 (100%) 50 (100%) Respiratory Epithelium, Metaplasia, Squamous 2 (4%) Trachea (49) (49) (49) (49) Metaplasia, Squamous 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC NITROMETHANE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (3) (5) Inflammation 3 (100%) 4 (80%) Harderian Gland (49) (50) (50) (49) Hyperplasia 2 (4%) 2 (4%) 6 (12%) 2 (4%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (49) Amyloid Deposition 1 (2%) Hydronephrosis 4 (8%) 1 (2%) 3 (6%) Inflammation, Suppurative 1 (2%) 4 (8%) 2 (4%) 2 (4%) Metaplasia, Osseous 1 (2%) 4 (8%) 1 (2%) 1 (2%) Nephropathy 35 (70%) 34 (68%) 33 (67%) 41 (84%) Cortex, Cyst 1 (2%) 1 (2%) Pelvis, Necrosis 1 (2%) Renal Tubule, Hyperplasia 2 (4%) 5 (10%) 2 (4%) 3 (6%) Renal Tubule, Mineralization 2 (4%) Ureter (1) Inflammation, Suppurative 1 (100%) Necrosis 1 (100%) Urethra (1) Inflammation, Suppurative 1 (100%) Urinary Bladder (48) (50) (49) (48) Calculus Gross Observation 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) 4 (8%) 2 (4%) 3 (6%) Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------