TDMS Study 05200-06 Pathology Tables
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
Facility: Battelle Northwest
Chemical CAS #: 75-52-5
Lock Date: 06/22/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 5 3 2
Moribund Sacrifice 16 17 20 12
Accidently Killed 2 1
Survivors
Terminal Sacrifice 25 27 26 36
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (48) (49) (49)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Gallbladder (40) (45) (45) (46)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Intestine Large, Cecum (49) (46) (47) (50)
Diverticulum 1 (2%)
Muscularis, Hyperplasia 1 (2%)
Intestine Small, Duodenum (48) (43) (45) (49)
Cyst 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Jejunum (47) (45) (47) (48)
Epithelium, Hyperplasia 1 (2%)
Liver (50) (49) (49) (50)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Eosinophilic Focus 4 (8%) 7 (14%) 11 (22%) 15 (30%)
Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%) 3 (6%) 1 (2%)
Mixed Cell Focus 2 (4%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 2 (4%) 3 (6%)
Vacuolization Cytoplasmic 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Degeneration, Fatty 1 (2%) 1 (2%)
Centrilobular, Necrosis 1 (2%) 3 (6%)
Mesentery (7) (14) (8) (11)
Hemorrhage 1 (7%)
Inflammation, Suppurative 1 (13%)
Fat, Hemorrhage 1 (13%)
Fat, Necrosis 6 (86%) 11 (79%) 5 (63%) 10 (91%)
Fat, Thrombosis 1 (7%)
Pancreas (50) (48) (48) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Basophilic Focus 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Duct, Cyst 1 (2%) 2 (4%)
Duct, Inflammation, Suppurative 1 (2%)
Salivary Glands (49) (48) (49) (50)
Atrophy 1 (2%)
Stomach, Forestomach (50) (48) (49) (50)
Angiectasis 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer 3 (6%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 4 (8%) 3 (6%) 1 (2%)
Stomach, Glandular (49) (48) (48) (50)
Degeneration, Hyaline 1 (2%)
Inflammation 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2)
Aorta, Mineralization 1 (100%) 1 (50%)
Heart (50) (50) (50) (50)
Cardiomyopathy 13 (26%) 23 (46%) 19 (38%) 18 (36%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%)
Endothelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (48) (49) (50)
Degeneration, Cystic 1 (2%) 3 (6%)
Hyperplasia 1 (2%) 2 (4%)
Hypertrophy 2 (4%) 4 (8%) 5 (10%) 3 (6%)
Capsule, Hyperplasia 2 (4%) 2 (4%)
Adrenal Medulla (50) (48) (49) (49)
Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (48) (47) (50)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (33) (34) (33) (34)
Cyst 1 (3%)
Pituitary Gland (50) (46) (48) (50)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 11 (22%) 20 (43%) 11 (23%) 18 (36%)
Pars Intermedia, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Hypertrophy 1 (2%)
Thyroid Gland (50) (48) (48) (50)
Follicular Cell, Hyperplasia 5 (10%) 4 (8%) 3 (6%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (47) (47) (48) (48)
Angiectasis 4 (9%) 2 (4%) 1 (2%)
Atrophy 14 (30%) 16 (34%) 14 (29%) 13 (27%)
Cyst 13 (28%) 14 (30%) 16 (33%) 13 (27%)
Hyperplasia, Tubular 3 (6%) 2 (4%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Bilateral, Cyst 1 (2%)
Granulosa Cell, Hyperplasia 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (49) (49) (50)
Adenomyosis 1 (2%)
Angiectasis 2 (4%) 2 (4%) 4 (8%)
Hemorrhage 1 (2%)
Hydrometra 3 (6%) 4 (8%) 5 (10%) 10 (20%)
Hyperplasia, Cystic 4 (8%) 6 (12%) 3 (6%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%) 2 (4%)
Myometrium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (48) (49) (50)
Hyperplasia 3 (6%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node (8) (6) (5) (6)
Ectasia 1 (13%)
Hyperplasia 1 (20%)
Iliac, Hematopoietic Cell Proliferation 1 (20%)
Iliac, Hyperplasia 2 (33%) 1 (17%)
Pancreatic, Hyperplasia 1 (17%)
Renal, Hematopoietic Cell Proliferation 1 (20%)
Renal, Hyperplasia 2 (33%) 1 (20%) 2 (33%)
Lymph Node, Bronchial (39) (36) (40) (40)
Hyperplasia 4 (10%) 5 (14%) 3 (8%) 2 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (43) (34) (38) (43)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia 1 (2%) 1 (3%) 5 (13%) 5 (12%)
Lymph Node, Mesenteric (48) (46) (46) (48)
Angiectasis 1 (2%) 1 (2%) 2 (4%)
Congestion 1 (2%) 1 (2%)
Hyperplasia 6 (13%) 9 (20%) 3 (7%) 4 (8%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node, Mediastinal (38) (37) (35) (41)
Hyperplasia 6 (16%) 5 (14%) 3 (9%) 2 (5%)
Spleen (50) (48) (49) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 13 (27%) 10 (20%) 12 (24%)
Hyperplasia, Lymphoid 5 (10%) 10 (21%) 6 (12%) 8 (16%)
Infiltration Cellular, Mast Cell 1 (2%)
Thymus (43) (39) (41) (47)
Atrophy 1 (2%) 2 (5%) 2 (5%)
Hyperplasia, Lymphoid 3 (7%) 2 (5%) 6 (15%) 5 (11%)
Infiltration Cellular, Mast Cell 1 (2%)
Necrosis 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (49) (50)
Hyperplasia 2 (4%)
Skin (49) (47) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Arthrosis 1 (2%)
Fibrous Osteodystrophy 17 (34%) 18 (36%) 18 (36%) 12 (24%)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Meninges, Infiltration Cellular, Mononuclear
Cell 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (48) (49) (50)
Inflammation, Suppurative 1 (2%)
Metaplasia, Squamous 1 (2%)
Lung (50) (50) (49) (50)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Histiocyte 1 (2%) 6 (12%) 4 (8%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 1 (2%) 5 (10%) 1 (2%)
Bronchus, Infiltration Cellular, Mixed Cell 1 (2%)
Mediastinum, Hemorrhage, Focal 1 (2%)
Mediastinum, Infiltration Cellular, Mast Cell 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%)
Mediastinum, Necrosis 1 (2%)
Perivascular, Inflammation, Chronic 1 (2%) 1 (2%)
Nose (50) (49) (50) (50)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Suppurative 2 (4%) 4 (8%) 1 (2%)
Glands, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 3 (6%) 3 (6%)
Olfactory Epithelium, Atrophy, Focal 2 (4%) 6 (12%)
Olfactory Epithelium, Degeneration 22 (45%) 50 (100%) 50 (100%)
Olfactory Epithelium, Metaplasia 2 (4%) 46 (92%) 48 (96%)
Respiratory Epithelium, Degeneration, Hyaline 16 (32%) 39 (80%) 50 (100%) 50 (100%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Inflammation 1 (100%) 1 (100%)
Harderian Gland (49) (49) (50) (50)
Fibrosis, Focal 1 (2%)
Hyperplasia 3 (6%) 2 (4%) 5 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (49) (50)
Amyloid Deposition 1 (2%)
Hydronephrosis 1 (2%)
Metaplasia, Osseous 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Nephropathy 12 (24%) 5 (10%) 7 (14%) 7 (14%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Mineralization 1 (2%) 1 (2%)
Urinary Bladder (49) (47) (47) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Suppurative 1 (2%) 2 (4%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 14 11 16 16
Natural Death 5 3 4 5
Survivors
Terminal Sacrifice 31 36 30 29
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (47) (43) (42)
Degeneration, Hyaline 1 (2%)
Hyperplasia 1 (2%)
Intestine Large, Cecum (46) (48) (47) (46)
Hemorrhage 1 (2%)
Intestine Small, Jejunum (45) (49) (47) (46)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 1 (2%) 3 (6%) 1 (2%)
Clear Cell Focus 2 (4%) 2 (4%) 2 (4%) 8 (16%)
Eosinophilic Focus 11 (22%) 8 (16%) 9 (18%) 11 (22%)
Hematopoietic Cell Proliferation 2 (4%)
Inflammation, Chronic 2 (4%) 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis 4 (8%) 3 (6%) 3 (6%) 2 (4%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Degeneration 1 (2%)
Mesentery (3) (6) (2)
Fat, Inflammation, Chronic 1 (17%)
Fat, Necrosis 3 (100%) 3 (50%) 2 (100%)
Pancreas (49) (50) (49) (49)
Angiectasis 1 (2%)
Atrophy 2 (4%)
Basophilic Focus 1 (2%)
Cytoplasmic Alteration 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Stomach, Forestomach (49) (50) (50) (48)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 4 (8%) 1 (2%)
Stomach, Glandular (48) (48) (48) (48)
Inflammation 1 (2%)
Ulcer 1 (2%) 2 (4%)
Tooth (3) (3) (1)
Developmental Malformation 2 (67%) 2 (67%) 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Dysplasia 1 (33%)
Infiltration Cellular, Mast Cell 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 20 (40%) 20 (40%) 20 (40%) 19 (38%)
Mineralization 1 (2%)
Artery, Thrombosis 1 (2%)
Atrium, Thrombosis 1 (2%)
Endothelium, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (48)
Degeneration 1 (2%)
Degeneration, Cystic 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 4 (8%) 4 (8%) 6 (12%) 6 (13%)
Hypertrophy 22 (45%) 22 (44%) 19 (39%) 22 (46%)
Capsule, Hyperplasia 2 (4%) 2 (4%)
Adrenal Medulla (49) (50) (49) (47)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (49) (50) (49) (49)
Hyperplasia 5 (10%) 4 (8%) 3 (6%) 4 (8%)
Parathyroid Gland (41) (34) (38) (37)
Cyst 1 (3%)
Pituitary Gland (47) (50) (46) (47)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (49) (48)
Follicular Cell, Hyperplasia 9 (18%) 3 (6%) 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Granuloma Sperm 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Penis (1) (2) (3) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Suppurative 1 (100%) 2 (100%) 1 (33%) 1 (100%)
Preputial Gland (49) (50) (49) (48)
Cyst 5 (10%) 3 (6%) 2 (4%) 4 (8%)
Inflammation, Chronic 4 (8%) 3 (6%) 5 (10%) 4 (8%)
Inflammation, Suppurative 1 (2%)
Bilateral, Cyst 1 (2%)
Prostate (49) (50) (47) (46)
Hyperplasia 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%) 2 (4%)
Seminal Vesicle (49) (49) (49) (47)
Hyperplasia 1 (2%)
Inflammation 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 4 (8%) 2 (4%) 4 (8%) 4 (8%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Angiectasis 1 (2%)
Hyperplasia 1 (2%) 2 (4%) 4 (8%) 1 (2%)
Lymph Node (3) (1) (1) (2)
Iliac, Hyperplasia 1 (33%) 2 (100%)
Renal, Hyperplasia 1 (100%)
Lymph Node, Bronchial (26) (26) (24) (28)
Hyperplasia 1 (4%) 1 (4%) 1 (4%)
Lymph Node, Mandibular (40) (39) (37) (43)
Hyperplasia 2 (5%) 1 (3%) 1 (3%) 4 (9%)
Lymph Node, Mesenteric (47) (46) (47) (49)
Angiectasis 3 (6%) 2 (4%)
Congestion 1 (2%)
Hyperplasia 3 (6%) 7 (15%) 2 (4%) 5 (10%)
Lymph Node, Mediastinal (35) (37) (36) (40)
Hyperplasia 2 (6%) 1 (3%) 1 (3%)
Spleen (49) (50) (50) (49)
Angiectasis 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 8 (16%) 9 (18%) 11 (22%) 7 (14%)
Hyperplasia, Lymphoid 2 (4%)
Thymus (33) (34) (33) (40)
Necrosis 1 (3%) 1 (3%) 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (49) (49) (48)
Inflammation, Suppurative 5 (10%) 1 (2%) 2 (4%)
Prepuce, Inflammation, Suppurative 6 (12%) 3 (6%) 8 (16%) 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (49) (48)
Inflammation, Suppurative 1 (2%) 1 (2%)
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 7 (14%) 2 (4%) 3 (6%) 6 (12%)
Inflammation, Chronic 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 3 (6%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%)
Perivascular, Inflammation, Chronic 2 (4%)
Nose (50) (49) (50) (50)
Inflammation, Suppurative 1 (2%) 5 (10%) 3 (6%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 3 (6%) 10 (20%) 10 (20%)
Olfactory Epithelium, Atrophy, Focal 3 (6%) 8 (16%)
Olfactory Epithelium, Degeneration 10 (20%) 50 (100%) 50 (100%)
Olfactory Epithelium, Metaplasia 1 (2%) 41 (82%) 49 (98%)
Respiratory Epithelium, Degeneration, Hyaline 5 (10%) 5 (10%) 50 (100%) 50 (100%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%)
Trachea (49) (49) (49) (49)
Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05200-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:10:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 188 PPM 375 PPM 750 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (5)
Inflammation 3 (100%) 4 (80%)
Harderian Gland (49) (50) (50) (49)
Hyperplasia 2 (4%) 2 (4%) 6 (12%) 2 (4%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (49)
Amyloid Deposition 1 (2%)
Hydronephrosis 4 (8%) 1 (2%) 3 (6%)
Inflammation, Suppurative 1 (2%) 4 (8%) 2 (4%) 2 (4%)
Metaplasia, Osseous 1 (2%) 4 (8%) 1 (2%) 1 (2%)
Nephropathy 35 (70%) 34 (68%) 33 (67%) 41 (84%)
Cortex, Cyst 1 (2%) 1 (2%)
Pelvis, Necrosis 1 (2%)
Renal Tubule, Hyperplasia 2 (4%) 5 (10%) 2 (4%) 3 (6%)
Renal Tubule, Mineralization 2 (4%)
Ureter (1)
Inflammation, Suppurative 1 (100%)
Necrosis 1 (100%)
Urethra (1)
Inflammation, Suppurative 1 (100%)
Urinary Bladder (48) (50) (49) (48)
Calculus Gross Observation 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 4 (8%) 2 (4%) 3 (6%)
Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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