TDMS Study 05200-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest NITROMETHANE DATE: 04/04/96
EXPERIMENT: 05200 TEST: 06 TIME: 06:24:52
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-75189 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61927
PATHOLOGIST: R. MILLER R. RENNE CAS: 75-52-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest NITROMETHANE DATE: 04/04/96
EXPERIMENT: 05200 TEST: 06 TIME: 06:24:52
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75189 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61927
PATHOLOGIST: R. MILLER R. RENNE CAS: 75-52-5
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest NITROMETHANE DATE: 04/04/96
EXPERIMENT: 05200 TEST: 06 TIME: 06:24:52
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75189 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61927
PATHOLOGIST: R. MILLER R. RENNE CAS: 75-52-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF NITROMETHANE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Carcinoma
Carcinoma or Adenoma
Liver Hepatocellular Carcinoma
Lung Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Uterus Hemangioma
All Organs Hemangioma
Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 1/50 (2%) 2/49 (4%) 5/48 (10%) | 1/50 (2%) 0/48 (0%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | 16.1% 2.8% 6.7% 16.4% | 4.0% 0.0% 3.8% 2.8% |
|TERMINAL (d) | 5/31 (16%) 1/36 (3%) 2/30 (7%) 4/28 (14%) | 1/25 (4%) 0/28 (0%) 1/26 (4%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) 734 (T) 649 | 734 (T) --- 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.324 P=0.071N P=0.226N P=0.576 | P=0.626 P=0.477N P=0.754N P=0.678N |
|INCIDENTAL TUMOR | P=0.341 P=0.071N P=0.226N P=0.599 | P=0.626 P=0.477N P=0.754N P=0.678N |
|LOGISTIC REGRESSION | P=0.356 P=0.071N P=0.226N P=0.620 | P=0.626 P=0.477N P=0.754N P=0.678N |
|COCHRAN-ARMITAGE | P=0.389 | P=0.542 |
|FISHER EXACT | P=0.098N P=0.218N P=0.617 | P=0.510N P=0.747 P=0.753N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/49 (0%) 1/47 (2%) | 0/50 (0%) 0/48 (0%) 2/49 (4%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.6% | 0.0% 0.0% 7.7% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 0/30 (0%) 1/28 (4%) | 0/25 (0%) 0/28 (0%) 2/26 (8%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 734 (T) | --- --- 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.176 (e) (e) P=0.480 | P=0.655 (e) P=0.246 (e) |
|INCIDENTAL TUMOR | P=0.176 (e) (e) P=0.480 | P=0.655 (e) P=0.246 (e) |
|LOGISTIC REGRESSION | P=0.176 (e) (e) P=0.480 | P=0.655 (e) P=0.246 (e) |
|COCHRAN-ARMITAGE | P=0.191 | P=0.593 |
|FISHER EXACT | (e) (e) P=0.490 | (e) P=0.242 (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 1/49 (2%) 1/47 (2%) | 0/50 (0%) 0/48 (0%) 2/49 (4%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.2% 3.6% | 0.0% 0.0% 7.7% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 0/30 (0%) 1/28 (4%) | 0/25 (0%) 0/28 (0%) 2/26 (8%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 534 734 (T) | --- --- 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.225 (e) P=0.500 P=0.480 | P=0.655 (e) P=0.246 (e) |
|INCIDENTAL TUMOR | P=0.120 (e) P=0.500 P=0.480 | P=0.655 (e) P=0.246 (e) |
|LOGISTIC REGRESSION | P=0.211 (e) P=0.581 P=0.480 | P=0.655 (e) P=0.246 (e) |
|COCHRAN-ARMITAGE | P=0.226 | P=0.593 |
|FISHER EXACT | (e) P=0.500 P=0.490 | (e) P=0.242 (e) |
|=================================================================================================================================|
| |
|Bone |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 3.6% 5.2% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 0/30 (0%) 0/29 (0%) | 0/25 (0%) 1/28 (4%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 734 (T) 568 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.553N P=0.523 P=0.248 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.656 P=0.523 P=0.263 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.622N P=0.523 P=0.234 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.616N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.247 (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/48 (0%) 2/49 (4%) 0/50 (0%) |
|ADJUSTED (b) | 3.2% 5.6% 0.0% 0.0% | 4.0% 0.0% 5.2% 0.0% |
|TERMINAL (d) | 1/31 (3%) 2/36 (6%) 0/30 (0%) 0/29 (0%) | 1/25 (4%) 0/28 (0%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) --- --- | 734 (T) --- 568 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.205N P=0.552 P=0.507N P=0.513N | P=0.402N P=0.477N P=0.513 P=0.427N |
|INCIDENTAL TUMOR | P=0.205N P=0.552 P=0.507N P=0.513N | P=0.502N P=0.477N P=0.515 P=0.427N |
|LOGISTIC REGRESSION | P=0.205N P=0.552 P=0.507N P=0.513N | P=0.463N P=0.477N P=0.492 P=0.427N |
|COCHRAN-ARMITAGE | P=0.185N | P=0.458N |
|FISHER EXACT | P=0.508 P=0.495N P=0.495N | P=0.510N P=0.492 P=0.500N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 10/50 (20%) 19/50 (38%) 32/50 (64%) | 5/50 (10%) 7/50 (14%) 16/50 (32%) 19/50 (38%) |
|ADJUSTED (b) | 26.6% 22.8% 51.9% 75.5% | 16.0% 21.4% 43.1% 45.9% |
|TERMINAL (d) | 7/31 (23%) 4/36 (11%) 13/30 (43%) 19/29 (66%) | 2/25 (8%) 4/28 (14%) 7/26 (27%) 14/36 (39%) |
|FIRST INCIDENCE (DAYS) | 545 448 520 497 | 609 639 498 503 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.555N P=0.023 * P<0.001 ** | P=0.008 ** P=0.413 P=0.016 * P=0.020 * |
|INCIDENTAL TUMOR | P<0.001 ** P=0.471 P=0.018 * P<0.001 ** | P<0.001 ** P=0.345 P=0.007 ** P=0.002 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.505 P=0.019 * P<0.001 ** | P<0.001 ** P=0.380 P=0.008 ** P=0.003 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.500 P=0.022 * P<0.001 ** | P=0.380 P=0.006 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 6/50 (12%) 5/50 (10%) | 1/50 (2%) 2/50 (4%) 4/50 (8%) 3/50 (6%) |
|ADJUSTED (b) | 2.6% 2.8% 16.5% 14.7% | 2.9% 6.7% 14.1% 8.3% |
|TERMINAL (d) | 0/31 (0%) 1/36 (3%) 3/30 (10%) 3/29 (10%) | 0/25 (0%) 1/28 (4%) 3/26 (12%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 653 734 (T) 436 595 | 663 693 679 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.031 * P=0.730N P=0.060 P=0.108 | P=0.364 P=0.506 P=0.195 P=0.425 |
|INCIDENTAL TUMOR | P=0.052 P=0.730N P=0.061 P=0.147 | P=0.284 P=0.439 P=0.198 P=0.363 |
|LOGISTIC REGRESSION | P=0.036 * P=0.762N P=0.062 P=0.104 | P=0.305 P=0.501 P=0.194 P=0.365 |
|COCHRAN-ARMITAGE | P=0.036 * | P=0.221 |
|FISHER EXACT | P=0.753N P=0.056 P=0.102 | P=0.500 P=0.181 P=0.309 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 11/50 (22%) 25/50 (50%) 37/50 (74%) | 6/50 (12%) 9/50 (18%) 20/50 (40%) 21/50 (42%) |
|ADJUSTED (b) | 28.4% 25.3% 63.2% 83.7% | 18.4% 27.1% 53.5% 50.8% |
|TERMINAL (d) | 7/31 (23%) 5/36 (14%) 16/30 (53%) 22/29 (76%) | 2/25 (8%) 5/28 (18%) 10/26 (38%) 16/36 (44%) |
|FIRST INCIDENCE (DAYS) | 545 448 436 497 | 609 639 498 503 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.540N P=0.003 ** P<0.001 ** | P=0.010 * P=0.324 P=0.005 ** P=0.019 * |
|INCIDENTAL TUMOR | P<0.001 ** P=0.485 P=0.001 ** P<0.001 ** | P<0.001 ** P=0.233 P=0.002 ** P=0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.506 P=0.001 ** P<0.001 ** | P<0.001 ** P=0.175 P=0.002 ** P=0.002 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.500 P=0.002 ** P<0.001 ** | P=0.288 P=0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 3/50 (6%) 0/49 (0%) 1/49 (2%) | 0/50 (0%) 0/48 (0%) 0/47 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.2% 7.8% 0.0% 2.4% | 0.0% 0.0% 0.0% 2.2% |
|TERMINAL (d) | 0/31 (0%) 2/36 (6%) 0/30 (0%) 0/29 (0%) | 0/25 (0%) 0/28 (0%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 534 679 --- 632 | --- --- --- 632 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.421N P=0.356 P=0.500N P=0.747N | P=0.223 (e) (e) P=0.534 |
|INCIDENTAL TUMOR | P=0.400N P=0.283 P=0.536N P=0.704 | P=0.126 (e) (e) P=0.362 |
|LOGISTIC REGRESSION | P=0.416N P=0.300 P=0.425N P=0.734 | P=0.193 (e) (e) P=0.486 |
|COCHRAN-ARMITAGE | P=0.412N | P=0.202 |
|FISHER EXACT | P=0.316 P=0.500N P=0.753N | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 0/50 (0%) | 2/50 (4%) 0/49 (0%) 2/49 (4%) 0/50 (0%) |
|ADJUSTED (b) | 3.2% 5.2% 6.7% 0.0% | 7.4% 0.0% 6.9% 0.0% |
|TERMINAL (d) | 1/31 (3%) 1/36 (3%) 2/30 (7%) 0/29 (0%) | 1/25 (4%) 0/28 (0%) 1/26 (4%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 721 734 (T) --- | 707 --- 693 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.330N P=0.560 P=0.488 P=0.513N | P=0.184N P=0.224N P=0.676N P=0.167N |
|INCIDENTAL TUMOR | P=0.300N P=0.548 P=0.488 P=0.513N | P=0.239N P=0.261N P=0.672N P=0.245N |
|LOGISTIC REGRESSION | P=0.319N P=0.559 P=0.488 P=0.513N | P=0.203N P=0.234N P=0.676N P=0.190N |
|COCHRAN-ARMITAGE | P=0.296N | P=0.247N |
|FISHER EXACT | P=0.500 P=0.500 P=0.500N | P=0.253N P=0.684 P=0.247N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 14/50 (28%) 13/50 (26%) 17/50 (34%) | 14/50 (28%) 25/49 (51%) 17/49 (35%) 35/50 (70%) |
|ADJUSTED (b) | 44.2% 38.9% 36.2% 52.5% | 45.5% 68.6% 49.0% 83.1% |
|TERMINAL (d) | 11/31 (35%) 14/36 (39%) 8/30 (27%) 14/29 (48%) | 9/25 (36%) 17/28 (61%) 10/26 (38%) 29/36 (81%) |
|FIRST INCIDENCE (DAYS) | 449 734 (T) 436 679 | 597 534 498 426 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.352 P=0.196N P=0.300N P=0.522 | P=0.022 * P=0.048 * P=0.395 P=0.009 ** |
|INCIDENTAL TUMOR | P=0.381 P=0.297N P=0.300N P=0.462 | P<0.001 ** P=0.014 * P=0.332 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.484 P=0.292N P=0.261N P=0.562N | P<0.001 ** P=0.013 * P=0.364 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.490 | P<0.001 ** |
|FISHER EXACT | P=0.333N P=0.257N P=0.583N | P=0.016 * P=0.308 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 14/50 (28%) 10/50 (20%) 9/50 (18%) | 10/50 (20%) 14/49 (29%) 8/49 (16%) 12/50 (24%) |
|ADJUSTED (b) | 35.6% 33.3% 21.9% 20.7% | 29.7% 35.7% 26.6% 25.6% |
|TERMINAL (d) | 5/31 (16%) 9/36 (25%) 1/30 (3%) 2/29 (7%) | 3/25 (12%) 6/28 (21%) 6/26 (23%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | 441 448 377 406 | 576 534 548 426 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.085N P=0.297N P=0.177N P=0.104N | P=0.322N P=0.296 P=0.362N P=0.495N |
|INCIDENTAL TUMOR | P=0.022N* P=0.505 P=0.090N P=0.065N | P=0.302 P=0.160 P=0.359N P=0.091 |
|LOGISTIC REGRESSION | P=0.032N* P=0.440 P=0.120N P=0.099N | P=0.329 P=0.195 P=0.383N P=0.200 |
|COCHRAN-ARMITAGE | P=0.051N | P=0.505 |
|FISHER EXACT | P=0.414N P=0.127N P=0.083N | P=0.224 P=0.416N P=0.405 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 24/50 (48%) 22/50 (44%) 26/50 (52%) | 19/50 (38%) 34/49 (69%) 22/49 (45%) 40/50 (80%) |
|ADJUSTED (b) | 60.6% 58.0% 48.4% 64.9% | 54.6% 82.4% 62.6% 86.9% |
|TERMINAL (d) | 13/31 (42%) 19/36 (53%) 8/30 (27%) 16/29 (55%) | 10/25 (40%) 21/28 (75%) 14/26 (54%) 30/36 (83%) |
|FIRST INCIDENCE (DAYS) | 441 448 377 406 | 576 534 498 426 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.502N P=0.119N P=0.210N P=0.405N | P=0.095 P=0.018 * P=0.420 P=0.032 * |
|INCIDENTAL TUMOR | P=0.344N P=0.393N P=0.104N P=0.432N | P<0.001 ** P<0.001 ** P=0.355 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.319N P=0.268N P=0.111N P=0.383N | P=0.001 ** P<0.001 ** P=0.368 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.360N | P<0.001 ** |
|FISHER EXACT | P=0.212N P=0.115N P=0.344N | P=0.002 ** P=0.311 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 24/50 (48%) 22/50 (44%) 26/50 (52%) | 19/50 (38%) 34/49 (69%) 22/49 (45%) 40/50 (80%) |
|ADJUSTED (b) | 60.6% 58.0% 48.4% 64.9% | 54.6% 82.4% 62.6% 86.9% |
|TERMINAL (d) | 13/31 (42%) 19/36 (53%) 8/30 (27%) 16/29 (55%) | 10/25 (40%) 21/28 (75%) 14/26 (54%) 30/36 (83%) |
|FIRST INCIDENCE (DAYS) | 441 448 377 406 | 576 534 498 426 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.502N P=0.119N P=0.210N P=0.405N | P=0.095 P=0.018 * P=0.420 P=0.032 * |
|INCIDENTAL TUMOR | P=0.344N P=0.393N P=0.104N P=0.432N | P<0.001 ** P<0.001 ** P=0.355 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.319N P=0.268N P=0.111N P=0.383N | P=0.001 ** P<0.001 ** P=0.368 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.360N | P<0.001 ** |
|FISHER EXACT | P=0.212N P=0.115N P=0.344N | P=0.002 ** P=0.311 P<0.001 ** |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 10/50 (20%) 9/50 (18%) 12/50 (24%) | 3/50 (6%) 3/50 (6%) 2/49 (4%) 9/50 (18%) |
|ADJUSTED (b) | 30.8% 26.0% 30.0% 35.1% | 11.5% 10.7% 4.3% 22.7% |
|TERMINAL (d) | 8/31 (26%) 8/36 (22%) 9/30 (30%) 8/29 (28%) | 2/25 (8%) 3/28 (11%) 0/26 (0%) 6/36 (17%) |
|FIRST INCIDENCE (DAYS) | 449 646 734 (T) 497 | 716 734 (T) 498 426 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.322 P=0.365N P=0.433N P=0.456 | P=0.065 P=0.610N P=0.466N P=0.186 |
|INCIDENTAL TUMOR | P=0.388 P=0.464N P=0.424N P=0.468 | P=0.020 * P=0.644N P=0.608N P=0.072 |
|LOGISTIC REGRESSION | P=0.422 P=0.456N P=0.412N P=0.511 | P=0.022 * P=0.632N P=0.514N P=0.083 |
|COCHRAN-ARMITAGE | P=0.430 | P=0.018 * |
|FISHER EXACT | P=0.500N P=0.402N P=0.500 | P=0.661N P=0.510N P=0.061 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 3/50 (6%) 11/50 (22%) | 0/50 (0%) 3/50 (6%) 5/49 (10%) 3/50 (6%) |
|ADJUSTED (b) | 6.5% 8.3% 10.0% 30.4% | 0.0% 8.3% 15.0% 7.2% |
|TERMINAL (d) | 2/31 (6%) 3/36 (8%) 3/30 (10%) 6/29 (21%) | 0/25 (0%) 1/28 (4%) 2/26 (8%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) 734 (T) 586 | --- 534 602 503 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.569 P=0.485 P=0.009 ** | P=0.264 P=0.134 P=0.041 * P=0.178 |
|INCIDENTAL TUMOR | P=0.002 ** P=0.569 P=0.485 P=0.015 * | P=0.088 P=0.117 P=0.040 * P=0.068 |
|LOGISTIC REGRESSION | P=0.001 ** P=0.569 P=0.485 P=0.009 ** | P=0.149 P=0.119 P=0.033 * P=0.110 |
|COCHRAN-ARMITAGE | P=0.001 ** | P=0.159 |
|FISHER EXACT | P=0.500 P=0.500 P=0.007 ** | P=0.121 P=0.027 * P=0.121 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 13/50 (26%) 12/50 (24%) 20/50 (40%) | 3/50 (6%) 6/50 (12%) 6/49 (12%) 12/50 (24%) |
|ADJUSTED (b) | 36.8% 33.9% 40.0% 51.2% | 11.5% 18.5% 16.8% 28.7% |
|TERMINAL (d) | 10/31 (32%) 11/36 (31%) 12/30 (40%) 11/29 (38%) | 2/25 (8%) 4/28 (14%) 2/26 (8%) 7/36 (19%) |
|FIRST INCIDENCE (DAYS) | 449 646 734 (T) 497 | 716 534 498 426 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.032 * P=0.427N P=0.540N P=0.099 | P=0.042 * P=0.293 P=0.280 P=0.066 |
|INCIDENTAL TUMOR | P=0.062 P=0.524N P=0.531N P=0.119 | P=0.004 ** P=0.252 P=0.193 P=0.010 ** |
|LOGISTIC REGRESSION | P=0.059 P=0.517N P=0.515N P=0.105 | P=0.007 ** P=0.243 P=0.238 P=0.015 * |
|COCHRAN-ARMITAGE | P=0.063 | P=0.007 ** |
|FISHER EXACT | P=0.590N P=0.500N P=0.101 | P=0.243 P=0.233 P=0.011 * |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 6.8% 5.9% 5.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 0/30 (0%) 0/29 (0%) | 1/25 (4%) 1/28 (4%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 667 569 548 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.124N P=0.685N P=0.677N P=0.179N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.193N P=0.685 P=0.664N P=0.245N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.170N P=0.695N P=0.693 P=0.217N |
|COCHRAN-ARMITAGE | (e) | P=0.163N |
|FISHER EXACT | (e) (e) (e) | P=0.691N P=0.691N P=0.247N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 6.8% 5.9% 7.6% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 0/30 (0%) 0/29 (0%) | 1/25 (4%) 1/28 (4%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 667 569 548 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.151N P=0.685N P=0.517 P=0.179N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.244N P=0.685 P=0.538 P=0.245N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.208N P=0.695N P=0.497 P=0.217N |
|COCHRAN-ARMITAGE | (e) | P=0.199N |
|FISHER EXACT | (e) (e) (e) | P=0.691N P=0.500 P=0.247N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 6.8% 5.9% 7.6% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 0/30 (0%) 0/29 (0%) | 1/25 (4%) 1/28 (4%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 667 569 548 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.151N P=0.685N P=0.517 P=0.179N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.244N P=0.685 P=0.538 P=0.245N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.208N P=0.695N P=0.497 P=0.217N |
|COCHRAN-ARMITAGE | (e) | P=0.199N |
|FISHER EXACT | (e) (e) (e) | P=0.691N P=0.500 P=0.247N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/47 (4%) 1/47 (2%) 0/48 (0%) 3/48 (6%) |
|ADJUSTED (b) | | 4.9% 3.6% 0.0% 8.1% |
|TERMINAL (d) | | 0/24 (0%) 1/28 (4%) 0/26 (0%) 2/34 (6%) |
|FIRST INCIDENCE (DAYS) | | 576 734 (T) --- 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.433 P=0.491N P=0.232N P=0.609 |
|INCIDENTAL TUMOR | | P=0.322 P=0.550N P=0.232N P=0.417 |
|LOGISTIC REGRESSION | | P=0.354 P=0.502N P=0.236N P=0.505 |
|COCHRAN-ARMITAGE | | P=0.345 |
|FISHER EXACT | | P=0.500N P=0.242N P=0.510 |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/47 (0%) 2/47 (4%) 0/48 (0%) 0/48 (0%) |
|ADJUSTED (b) | | 0.0% 6.7% 0.0% 0.0% |
|TERMINAL (d) | | 0/24 (0%) 1/28 (4%) 0/26 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 693 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.348N P=0.257 (e) (e) |
|INCIDENTAL TUMOR | | P=0.386N P=0.228 (e) (e) |
|LOGISTIC REGRESSION | | P=0.369N P=0.244 (e) (e) |
|COCHRAN-ARMITAGE | | P=0.401N |
|FISHER EXACT | | P=0.247 (e) (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 0/50 (0%) 0/46 (0%) 0/47 (0%) | 9/50 (18%) 10/46 (22%) 8/48 (17%) 4/50 (8%) |
|ADJUSTED (b) | 2.4% 0.0% 0.0% 0.0% | 30.3% 33.9% 32.0% 10.8% |
|TERMINAL (d) | 0/29 (0%) 0/36 (0%) 0/29 (0%) 0/29 (0%) | 6/25 (24%) 8/27 (30%) 8/25 (32%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 609 --- --- --- | 597 656 734 (T) 729 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306N P=0.481N P=0.515N P=0.491N | P=0.014N* P=0.544 P=0.494N P=0.036N* |
|INCIDENTAL TUMOR | P=0.227N P=0.773N P=0.455N P=0.419N | P=0.022N* P=0.475 P=0.490N P=0.081N |
|LOGISTIC REGRESSION | P=0.315N P=0.506N P=0.490N P=0.536N | P=0.019N* P=0.456 P=0.470N P=0.063N |
|COCHRAN-ARMITAGE | P=0.308N | P=0.064N |
|FISHER EXACT | P=0.485N P=0.505N P=0.500N | P=0.419 P=0.537N P=0.117N |
|=================================================================================================================================|
| |
|Skin |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.3% 0.0% | 0.0% 0.0% 6.9% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 1/30 (3%) 0/29 (0%) | 0/25 (0%) 0/28 (0%) 1/26 (4%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 734 (T) --- | --- --- 693 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.682 (e) P=0.493 (e) | P=0.655 (e) P=0.248 (e) |
|INCIDENTAL TUMOR | P=0.682 (e) P=0.493 (e) | P=0.601 (e) P=0.254 (e) |
|LOGISTIC REGRESSION | P=0.682 (e) P=0.493 (e) | P=0.631 (e) P=0.250 (e) |
|COCHRAN-ARMITAGE | P=0.695 | P=0.595 |
|FISHER EXACT | (e) P=0.500 (e) | (e) P=0.247 (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.2% 2.6% 3.3% 4.4% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 0/30 (0%) 0/29 (0%) | 0/25 (0%) 0/28 (0%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 693 637 716 553 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.431 P=0.754N P=0.741N P=0.563 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.193 P=0.725 P=0.746N P=0.290 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.334 P=0.762N P=0.753N P=0.474 |
|COCHRAN-ARMITAGE | (e) | P=0.351 |
|FISHER EXACT | (e) (e) (e) | P=0.753N P=0.753N P=0.500 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 5.3% 0.0% 3.4% | 4.0% 3.6% 0.0% 5.6% |
|TERMINAL (d) | 0/31 (0%) 1/36 (3%) 0/30 (0%) 1/29 (3%) | 1/25 (4%) 1/28 (4%) 0/26 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | --- 728 --- 734 (T) | 734 (T) 734 (T) --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.504 P=0.276 (e) P=0.487 | P=0.473 P=0.737N P=0.492N P=0.627 |
|INCIDENTAL TUMOR | P=0.552 P=0.270 (e) P=0.487 | P=0.473 P=0.737N P=0.492N P=0.627 |
|LOGISTIC REGRESSION | P=0.513 P=0.277 (e) P=0.487 | P=0.473 P=0.737N P=0.492N P=0.627 |
|COCHRAN-ARMITAGE | P=0.539 | P=0.366 |
|FISHER EXACT | P=0.247 (e) P=0.500 | P=0.753N P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 2.8% 0.0% 3.4% | 4.0% 3.6% 0.0% 5.6% |
|TERMINAL (d) | 0/31 (0%) 1/36 (3%) 0/30 (0%) 1/29 (3%) | 1/25 (4%) 1/28 (4%) 0/26 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | --- 734 (T) --- 734 (T) | 734 (T) 734 (T) --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.377 P=0.530 (e) P=0.487 | P=0.473 P=0.737N P=0.492N P=0.627 |
|INCIDENTAL TUMOR | P=0.377 P=0.530 (e) P=0.487 | P=0.473 P=0.737N P=0.492N P=0.627 |
|LOGISTIC REGRESSION | P=0.377 P=0.530 (e) P=0.487 | P=0.473 P=0.737N P=0.492N P=0.627 |
|COCHRAN-ARMITAGE | P=0.405 | P=0.366 |
|FISHER EXACT | P=0.500 (e) P=0.500 | P=0.753N P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 1/50 (2%) | |
|ADJUSTED (b) | 6.5% 2.7% 3.3% 3.4% | |
|TERMINAL (d) | 2/31 (6%) 0/36 (0%) 1/30 (3%) 1/29 (3%) | |
|FIRST INCIDENCE (DAYS) | 734 (T) 731 734 (T) 734 (T) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.450N P=0.449N P=0.512N P=0.523N | |
|INCIDENTAL TUMOR | P=0.414N P=0.452N P=0.512N P=0.523N | |
|LOGISTIC REGRESSION | P=0.451N P=0.436N P=0.512N P=0.523N | |
|COCHRAN-ARMITAGE | P=0.409N | |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/49 (0%) 1/48 (2%) | 4/50 (8%) 1/48 (2%) 1/48 (2%) 1/50 (2%) |
|ADJUSTED (b) | 3.2% 0.0% 0.0% 3.4% | 12.2% 2.6% 4.0% 2.8% |
|TERMINAL (d) | 1/31 (3%) 0/36 (0%) 0/30 (0%) 1/29 (3%) | 2/25 (8%) 0/28 (0%) 1/25 (4%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 734 (T) --- --- 734 (T) | 385 581 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.571 P=0.470N P=0.507N P=0.747 | P=0.096N P=0.177N P=0.180N P=0.116N |
|INCIDENTAL TUMOR | P=0.571 P=0.470N P=0.507N P=0.747 | P=0.156N P=0.216N P=0.263N P=0.201N |
|LOGISTIC REGRESSION | P=0.571 P=0.470N P=0.507N P=0.747 | P=0.144N P=0.196N P=0.196N P=0.198N |
|COCHRAN-ARMITAGE | P=0.587 | P=0.134N |
|FISHER EXACT | P=0.500N P=0.505N P=0.742 | P=0.194N P=0.194N P=0.181N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/49 (0%) 1/48 (2%) | 4/50 (8%) 1/48 (2%) 1/48 (2%) 1/50 (2%) |
|ADJUSTED (b) | 3.2% 2.8% 0.0% 3.4% | 12.2% 2.6% 4.0% 2.8% |
|TERMINAL (d) | 1/31 (3%) 1/36 (3%) 0/30 (0%) 1/29 (3%) | 2/25 (8%) 0/28 (0%) 1/25 (4%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) --- 734 (T) | 385 581 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.649N P=0.728N P=0.507N P=0.747 | P=0.096N P=0.177N P=0.180N P=0.116N |
|INCIDENTAL TUMOR | P=0.649N P=0.728N P=0.507N P=0.747 | P=0.156N P=0.216N P=0.263N P=0.201N |
|LOGISTIC REGRESSION | P=0.649N P=0.728N P=0.507N P=0.747 | P=0.144N P=0.196N P=0.196N P=0.198N |
|COCHRAN-ARMITAGE | P=0.627N | P=0.134N |
|FISHER EXACT | P=0.753N P=0.505N P=0.742 | P=0.194N P=0.194N P=0.181N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 5/50 (10%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 6.3% 15.7% 0.0% 0.0% |
|TERMINAL (d) | | 1/25 (4%) 3/28 (11%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | | 597 569 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.034N* P=0.239 P=0.230N P=0.191N |
|INCIDENTAL TUMOR | | P=0.049N* P=0.226 P=0.223N P=0.267N |
|LOGISTIC REGRESSION | | P=0.048N* P=0.217 P=0.238N P=0.242N |
|COCHRAN-ARMITAGE | | P=0.052N |
|FISHER EXACT | | P=0.218 P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 4/50 (8%) 2/50 (4%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | | 14.0% 7.1% 3.8% 8.0% |
|TERMINAL (d) | | 3/25 (12%) 2/28 (7%) 1/26 (4%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | | 576 734 (T) 734 (T) 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.308N P=0.299N P=0.169N P=0.327N |
|INCIDENTAL TUMOR | | P=0.363N P=0.294N P=0.164N P=0.445N |
|LOGISTIC REGRESSION | | P=0.361N P=0.333N P=0.166N P=0.431N |
|COCHRAN-ARMITAGE | | P=0.456N |
|FISHER EXACT | | P=0.339N P=0.181N P=0.500N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 6/50 (12%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 10.2% 19.0% 0.0% 2.4% |
|TERMINAL (d) | 0/31 (0%) 0/36 (0%) 0/30 (0%) 0/29 (0%) | 2/25 (8%) 4/28 (14%) 0/26 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 597 569 --- 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.044N* P=0.275 P=0.115N P=0.215N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.068N P=0.263 P=0.111N P=0.339N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.064N P=0.243 P=0.116N P=0.292N |
|COCHRAN-ARMITAGE | (e) | P=0.077N |
|FISHER EXACT | (e) (e) (e) | P=0.243 P=0.121N P=0.309N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 2/50 (4%) 0/50 (0%) | 4/50 (8%) 1/50 (2%) 5/50 (10%) 0/50 (0%) |
|ADJUSTED (b) | 3.2% 10.6% 6.7% 0.0% | 15.1% 3.6% 16.2% 0.0% |
|TERMINAL (d) | 1/31 (3%) 3/36 (8%) 2/30 (7%) 0/29 (0%) | 3/25 (12%) 1/28 (4%) 3/26 (12%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 721 734 (T) --- | 707 734 (T) 568 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231N P=0.234 P=0.488 P=0.513N | P=0.063N P=0.152N P=0.526 P=0.028N* |
|INCIDENTAL TUMOR | P=0.210N P=0.227 P=0.488 P=0.513N | P=0.087N P=0.171N P=0.536 P=0.043N* |
|LOGISTIC REGRESSION | P=0.222N P=0.235 P=0.488 P=0.513N | P=0.081N P=0.160N P=0.533 P=0.031N* |
|COCHRAN-ARMITAGE | P=0.199N | P=0.114N |
|FISHER EXACT | P=0.181 P=0.500 P=0.500N | P=0.181N P=0.500 P=0.059N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 2/50 (4%) 0/50 (0%) | 7/50 (14%) 7/50 (14%) 5/50 (10%) 1/50 (2%) |
|ADJUSTED (b) | 3.2% 10.6% 6.7% 0.0% | 24.7% 22.4% 16.2% 2.4% |
|TERMINAL (d) | 1/31 (3%) 3/36 (8%) 2/30 (7%) 0/29 (0%) | 5/25 (20%) 5/28 (18%) 3/26 (12%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 721 734 (T) --- | 597 569 568 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231N P=0.234 P=0.488 P=0.513N | P=0.006N** P=0.556N P=0.352N P=0.011N* |
|INCIDENTAL TUMOR | P=0.210N P=0.227 P=0.488 P=0.513N | P=0.013N* P=0.586N P=0.338N P=0.028N* |
|LOGISTIC REGRESSION | P=0.222N P=0.235 P=0.488 P=0.513N | P=0.011N* P=0.612N P=0.347N P=0.020N* |
|COCHRAN-ARMITAGE | P=0.199N | P=0.019N* |
|FISHER EXACT | P=0.181 P=0.500 P=0.500N | P=0.613N P=0.380N P=0.030N* |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 3/50 (6%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 8.7% 0.0% 8.6% 3.4% | 7.1% 0.0% 9.7% 0.0% |
|TERMINAL (d) | 1/31 (3%) 0/36 (0%) 1/30 (3%) 1/29 (3%) | 1/25 (4%) 0/28 (0%) 1/26 (4%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 653 --- 563 734 (T) | 693 --- 631 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.405N P=0.101N P=0.648 P=0.326N | P=0.221N P=0.227N P=0.524 P=0.172N |
|INCIDENTAL TUMOR | P=0.292N P=0.098N P=0.652N P=0.247N | P=0.318N P=0.261N P=0.533 P=0.245N |
|LOGISTIC REGRESSION | P=0.373N P=0.110N P=0.659 P=0.297N | P=0.260N P=0.235N P=0.522 P=0.201N |
|COCHRAN-ARMITAGE | P=0.372N | P=0.296N |
|FISHER EXACT | P=0.121N P=0.661N P=0.309N | P=0.247N P=0.500 P=0.247N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 2/50 (4%) 1/50 (2%) | 9/50 (18%) 7/50 (14%) 7/50 (14%) 7/50 (14%) |
|ADJUSTED (b) | 8.4% 9.6% 6.3% 2.4% | 23.4% 20.7% 21.3% 17.5% |
|TERMINAL (d) | 2/31 (6%) 1/36 (3%) 1/30 (3%) 0/29 (0%) | 2/25 (8%) 4/28 (14%) 3/26 (12%) 4/36 (11%) |
|FIRST INCIDENCE (DAYS) | 490 479 707 649 | 385 416 609 603 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.187N P=0.558 P=0.511N P=0.315N | P=0.196N P=0.382N P=0.368N P=0.223N |
|INCIDENTAL TUMOR | P=0.163N P=0.427 P=0.523N P=0.353N | P=0.492N P=0.442N P=0.476N P=0.612N |
|LOGISTIC REGRESSION | P=0.162N P=0.465 P=0.501N P=0.315N | P=0.389N P=0.397N P=0.404N P=0.440N |
|COCHRAN-ARMITAGE | P=0.162N | P=0.369N |
|FISHER EXACT | P=0.500 P=0.500N P=0.309N | P=0.393N P=0.393N P=0.393N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 31/50 (62%) 31/50 (62%) 33/50 (66%) 43/50 (86%) | 31/50 (62%) 39/50 (78%) 33/50 (66%) 43/50 (86%) |
|ADJUSTED (b) | 74.9% 67.3% 84.3% 95.5% | 78.8% 95.1% 86.2% 91.4% |
|TERMINAL (d) | 21/31 (68%) 21/36 (58%) 24/30 (80%) 27/29 (93%) | 17/25 (68%) 26/28 (93%) 21/26 (81%) 32/36 (89%) |
|FIRST INCIDENCE (DAYS) | 449 448 436 497 | 385 534 498 51 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003 ** P=0.289N P=0.364 P=0.020 * | P=0.422N P=0.208 P=0.522 P=0.533 |
|INCIDENTAL TUMOR | P=0.004 ** P=0.580N P=0.355 P=0.008 ** | P=0.047 * P=0.042 * P=0.464 P=0.018 * |
|LOGISTIC REGRESSION | P=0.002 ** P=0.521N P=0.378 P=0.007 ** | P=0.041 * P=0.043 * P=0.512 P=0.011 * |
|COCHRAN-ARMITAGE | P=0.003 ** | P=0.014 * |
|FISHER EXACT | P=0.582N P=0.418 P=0.006 ** | P=0.063 P=0.418 P=0.006 ** |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 188 PPM 375 PPM 750 PPM | CONTROL 188 PPM 375 PPM 750 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 25/50 (50%) 24/50 (48%) 22/50 (44%) | 26/50 (52%) 24/50 (48%) 28/50 (56%) 21/50 (42%) |
|ADJUSTED (b) | 48.3% 55.3% 51.9% 50.0% | 61.1% 56.6% 67.4% 42.9% |
|TERMINAL (d) | 9/31 (29%) 16/36 (44%) 9/30 (30%) 9/29 (31%) | 9/25 (36%) 11/28 (39%) 13/26 (50%) 8/36 (22%) |
|FIRST INCIDENCE (DAYS) | 441 448 377 406 | 385 416 548 426 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.489 P=0.559 P=0.403 P=0.556 | P=0.048N* P=0.385N P=0.515 P=0.055N |
|INCIDENTAL TUMOR | P=0.360N P=0.162 P=0.389 P=0.552N | P=0.465N P=0.518N P=0.464 P=0.545 |
|LOGISTIC REGRESSION | P=0.407N P=0.145 P=0.343 P=0.534 | P=0.404N P=0.398N P=0.462 P=0.520N |
|COCHRAN-ARMITAGE | P=0.472N | P=0.215N |
|FISHER EXACT | P=0.344 P=0.421 P=0.580N | P=0.421N P=0.421 P=0.212N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 40/50 (80%) 39/50 (78%) 43/50 (86%) 46/50 (92%) | 38/50 (76%) 45/50 (90%) 43/50 (86%) 46/50 (92%) |
|ADJUSTED (b) | 83.0% 81.2% 89.5% 95.8% | 86.2% 100.0% 97.7% 92.0% |
|TERMINAL (d) | 23/31 (74%) 27/36 (75%) 25/30 (83%) 27/29 (93%) | 19/25 (76%) 28/28 (100%) 25/26 (96%) 32/36 (89%) |
|FIRST INCIDENCE (DAYS) | 441 448 377 406 | 385 416 498 51 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.057 P=0.209N P=0.322 P=0.178 | P=0.157N P=0.288 P=0.368 P=0.286N |
|INCIDENTAL TUMOR | P=0.049 * P=0.501 P=0.220 P=0.079 | P=0.059 P=0.024 * P=0.165 P=0.025 * |
|LOGISTIC REGRESSION | P=0.032 * P=0.523N P=0.211 P=0.070 | P=0.070 P=0.040 * P=0.198 P=0.040 * |
|COCHRAN-ARMITAGE | P=0.034 * | P=0.037 * |
|FISHER EXACT | P=0.500N P=0.298 P=0.074 | P=0.054 P=0.154 P=0.027 * |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05200 TEST: 06 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROMETHANE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).