TDMS Study 05200-06 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
NITROMETHANE
NTP Experiment-Test: 05200-06 Report: PEIRPT09
Study Type: CHRONIC Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 75-52-5
Lock Date: 06/22/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 3| 7| 7| 6| 3| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 6| 6| 3| 7| 3| 3| 3| 0| 0| 9| 9| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 7| 4| 3| 7| 7| 6| 4| 7| 2| 1| 7| 7| 3| 5| 1| 5| 5| 4| 5| 5| 9| 6| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Gallbladder | A + + + + + + M + + A A + M I + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + A + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | |
Necrosis | |
Centrilobular, Degeneration, Fatty | 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 2 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Basophilic Focus | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Ulcer | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 |
Mineralization | 2 |
Artery, Inflammation | 2 |
Endothelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hypertrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 3| 7| 7| 6| 3| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 6| 6| 3| 7| 3| 3| 3| 0| 0| 9| 9| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 7| 4| 3| 7| 7| 6| 4| 7| 2| 1| 7| 7| 3| 5| 1| 5| 5| 4| 5| 5| 9| 6| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + M M + + + + + + + M I M + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 4 1 2 2 1 4|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + M + + M + + + M + +|
__________________________________________________________________________|
Ovary | + + + I + + + + + + + + + + + + + + + + + + + I +|
Angiectasis | 1 2 |
Atrophy | 1 2 3 2 2 2 2 2 |
Cyst | 1 4 2 2 1 2 2 |
Hyperplasia, Tubular | 1 |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hydrometra | 2 4 |
Hyperplasia, Cystic | 3 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + + + + M + + + + + M + + + + + + + M + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M + + + M M M + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | |
Congestion | 3 |
Hyperplasia | 2 2 2 2 2 |
Infiltration Cellular, Mast Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + + + M + + + M + + M + + + + + + + + + M +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 3| 7| 7| 6| 3| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 6| 6| 3| 7| 3| 3| 3| 0| 0| 9| 9| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 7| 4| 3| 7| 7| 6| 4| 7| 2| 1| 7| 7| 3| 5| 1| 5| 5| 4| 5| 5| 9| 6| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 1 2 |
Infiltration Cellular, Mast Cell | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + M + M + +|
Atrophy | 3 |
Hyperplasia, Lymphoid | 3 2 2 |
Infiltration Cellular, Mast Cell | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arthrosis | 2 |
Fibrous Osteodystrophy | 2 1 1 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 1 |
Alveolar Epithelium, Hyperplasia | 3|
Bronchus, Infiltration Cellular, | |
Mixed Cell | 2 |
Mediastinum, Hemorrhage, Focal | 2 |
Mediastinum, Infiltration Cellular, | |
Mast Cell | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Atrophy, Focal | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 3| 7| 7| 6| 3| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 6| 6| 3| 7| 3| 3| 3| 0| 0| 9| 9| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 7| 4| 3| 7| 7| 6| 4| 7| 2| 1| 7| 7| 3| 5| 1| 5| 5| 4| 5| 5| 9| 6| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + I + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 3| 6| 6| 7| 7| 6| 4| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 5| 3| 7| 8| 1| 6| 3| 1| 1| 3| 3| 3| 3| 9| 0| 3| 3| 3| 8| 3| 9| 3| 3| |
| 6| 6| 7| 5| 6| 5| 7| 7| 7| 6| 8| 6| 6| 4| 5| 3| 7| 6| 4| 4| 1| 5| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + I + + + + M + + M + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Muscularis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Eosinophilic Focus | X X X | 4 |
Hematopoietic Cell Proliferation | 2 2| 2 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis | 3 3 | 2 3.0|
Centrilobular, Degeneration, Fatty | | 1 2.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + +| 7 |
Fat, Necrosis | 2 3| 6 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 2 3.5|
Basophilic Focus | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Ulcer | 2 1| 3 1.7|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 1 1 | 13 1.1|
Mineralization | | 1 2.0|
Artery, Inflammation | | 1 2.0|
Endothelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 3| 6| 6| 7| 7| 6| 4| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 5| 3| 7| 8| 1| 6| 3| 1| 1| 3| 3| 3| 3| 9| 0| 3| 3| 3| 8| 3| 9| 3| 3| |
| 6| 6| 7| 5| 6| 5| 7| 7| 7| 6| 8| 6| 6| 4| 5| 3| 7| 6| 4| 4| 1| 5| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 2.0|
Hypertrophy | 1 | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M M + + I + + M M + + + + + + + M + M +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 1 3 2 4 3 | 11 2.5|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + M + + + + + + M M M + + + + + + + M + M +| 39 |
__________________________________________________________________________|____________|
Ovary | + + I + + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | 2 3 | 4 2.0|
Atrophy | 4 2 3 2 2 1 | 14 2.1|
Cyst | 2 2 4 2 3 2 | 13 2.2|
Hyperplasia, Tubular | 3 2 | 3 2.0|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 1.0|
Hydrometra | 3 | 3 3.0|
Hyperplasia, Cystic | 4 2 | 4 2.8|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + M M + + M + + + + + + + M + M + +| 39 |
Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 3| 6| 6| 7| 7| 6| 4| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 5| 3| 7| 8| 1| 6| 3| 1| 1| 3| 3| 3| 3| 9| 0| 3| 3| 3| 8| 3| 9| 3| 3| |
| 6| 6| 7| 5| 6| 5| 7| 7| 7| 6| 8| 6| 6| 4| 5| 3| 7| 6| 4| 4| 1| 5| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + M + +| 43 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 1 2.0|
Congestion | | 1 3.0|
Hyperplasia | 2 | 6 2.0|
Infiltration Cellular, Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + M M + + + M + + M + M + + + + + + +| 38 |
Hyperplasia | 2 1 4| 6 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 1| 10 2.1|
Hyperplasia, Lymphoid | | 5 1.8|
Infiltration Cellular, Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + I + + + + + M + + + + M + + + +| 43 |
Atrophy | | 1 3.0|
Hyperplasia, Lymphoid | | 3 2.3|
Infiltration Cellular, Mast Cell | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arthrosis | | 1 2.0|
Fibrous Osteodystrophy | 2 1 1 1 2 1 1 1 1 | 17 1.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + I + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 2 | 3 2.3|
Bronchus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 3| 6| 6| 7| 7| 6| 4| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 5| 3| 7| 8| 1| 6| 3| 1| 1| 3| 3| 3| 3| 9| 0| 3| 3| 3| 8| 3| 9| 3| 3| |
| 6| 6| 7| 5| 6| 5| 7| 7| 7| 6| 8| 6| 6| 4| 5| 3| 7| 6| 4| 4| 1| 5| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mixed Cell | | 1 2.0|
Mediastinum, Hemorrhage, Focal | | 1 2.0|
Mediastinum, Infiltration Cellular, | | |
Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Atrophy, Focal | 1 1 | 2 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 1 1 1 2 | 16 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 1 1 1 1 | 12 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| 6| 3| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 6| 6| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3|
| 5| 6| 5| 7| 6| 6| 6| 5| 7| 3| 4| 9| 9| 5| 3| 4| 1| 6| 6| 4| 5| 4| 7| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + A + + A + A + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + M + A + + M + A + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 3 2 |
Inflammation, Chronic | 2 2 |
Mixed Cell Focus | X |
Necrosis | 2 |
Bile Duct, Cyst | |
Centrilobular, Degeneration, Fatty | 3 |
Centrilobular, Necrosis | 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Hemorrhage | |
Fat, Necrosis | 4 3 4 2 3 2 4 2|
Fat, Thrombosis | 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Basophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 1 1 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| 6| 3| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 6| 6| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3|
| 5| 6| 5| 7| 6| 6| 6| 5| 7| 3| 4| 9| 9| 5| 3| 4| 1| 6| 6| 4| 5| 4| 7| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + M M + M + M + M + + + + + + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3|
Pars Distalis, Hyperplasia | 1 2 2 2 4 1 3|
Pars Intermedia, Hypertrophy | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + M + + + M + + M + + M M + M + + + M|
__________________________________________________________________________|
Ovary | + + + A + + + + + I + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Atrophy | 1 2 2 2 2 3 2 3|
Cyst | 2 4 2 1 |
Hyperplasia, Tubular | 2 |
Bilateral, Cyst | 4 |
Granulosa Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + A + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Hydrometra | 4 3 3 |
Hyperplasia, Cystic | 4 4 2 3 4 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia | 1 |
Renal, Hyperplasia | 2 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + A M + + + + + + + + + + M + + M M + M + + M|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M A M M + + + M + + + M + + + + M + + M + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + M + + + + + + M + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| 6| 3| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 6| 6| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3|
| 5| 6| 5| 7| 6| 6| 6| 5| 7| 3| 4| 9| 9| 5| 3| 4| 1| 6| 6| 4| 5| 4| 7| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + A + + + + + + + M + M + + + + + + + + + M I|
Hyperplasia | 2 3 4 2 |
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + A M + M + + + M + + + + + + + M M + I + + +|
Atrophy | 4 |
Hyperplasia, Lymphoid | 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 1 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Necrosis | 2 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy, Focal | 1 1 1 1 |
Olfactory Epithelium, Degeneration | 1 1 2 1 1 2 1 1 1 1 1 1 1 |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 2 1 2 1 2 2 1 2 1 1 2 2 1 1 2 1 1|
__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| 6| 3| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 6| 6| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3|
| 5| 6| 5| 7| 6| 6| 6| 5| 7| 3| 4| 9| 9| 5| 3| 4| 1| 6| 6| 4| 5| 4| 7| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 3| 5| 7| 6| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 7| 5| 6| 3| 9| 3| 5| 3| 3| 1| 3| 3| 4| 3| 3| 3| 4| 3| 3| 3| 5| 3| |
| 6| 5| 7| 9| 7| 9| 5| 3| 5| 6| 7| 4| 6| 7| 5| 1| 6| 5| 6| 6| 5| 4| 7| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 45 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + M + + + + + + + + + + + + + + + + + + +| 43 |
Peyer's Patch, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Eosinophilic Focus | X X X | 7 |
Hematopoietic Cell Proliferation | 1 2 | 4 2.0|
Inflammation, Chronic | 3 | 3 2.3|
Mixed Cell Focus | X | 2 |
Necrosis | 3 | 2 2.5|
Bile Duct, Cyst | 2 | 1 2.0|
Centrilobular, Degeneration, Fatty | | 1 3.0|
Centrilobular, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 14 |
Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 1 2 4 | 11 2.8|
Fat, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 4 | 2 4.0|
Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 | 23 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 3| 5| 7| 6| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 7| 5| 6| 3| 9| 3| 5| 3| 3| 1| 3| 3| 4| 3| 3| 3| 4| 3| 3| 3| 5| 3| |
| 6| 5| 7| 9| 7| 9| 5| 3| 5| 6| 7| 4| 6| 7| 5| 1| 6| 5| 6| 6| 5| 4| 7| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 1| 4 1.0|
Capsule, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + + + M + + + + + M + + M + M + + + + + I| 34 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + A + + + + + + + + M M + + + + + + + + + + +| 46 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hyperplasia | 3 3 2 1 4 1 1 1 1 1 1 1 1| 20 1.8|
Pars Intermedia, Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 2 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + A + + M + + + + + M + M + + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Ovary | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | 2 | 2 3.0|
Atrophy | 2 1 1 2 2 2 2 3| 16 2.0|
Cyst | 4 2 4 2 4 3 1 1 2 2| 14 2.4|
Hyperplasia, Tubular | 1 | 2 1.5|
Bilateral, Cyst | | 1 4.0|
Granulosa Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 2 2.5|
Hydrometra | 2 | 4 3.0|
Hyperplasia, Cystic | 4 | 6 3.5|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 3| 5| 7| 6| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 7| 5| 6| 3| 9| 3| 5| 3| 3| 1| 3| 3| 4| 3| 3| 3| 4| 3| 3| 3| 5| 3| |
| 6| 5| 7| 9| 7| 9| 5| 3| 5| 6| 7| 4| 6| 7| 5| 1| 6| 5| 6| 6| 5| 4| 7| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 6 |
Iliac, Hyperplasia | 4 | 2 2.5|
Renal, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + + + + + + + + + M + + M + + M + + M +| 36 |
Hyperplasia | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + A M + M M + M + + + + + + + M + + + + + + +| 34 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
Congestion | 3 | 1 3.0|
Hyperplasia | 3 2 4 | 9 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + A + + + M + M + + M M + M + + + + + + + + +| 37 |
Hyperplasia | 2 | 5 2.6|
__________________________________________________________________________|____________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 2 3 1 2 2 | 13 2.3|
Hyperplasia, Lymphoid | 2 2 1 1 4 1 | 10 1.9|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + M + + + M + + M + + + + + + +| 39 |
Atrophy | 4 | 2 4.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + A + + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skin | + + + M + + + + + + + + M + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 1 2 1 1 1 1 3 1| 18 1.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 1.0|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 3| 5| 7| 6| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 7| 5| 6| 3| 9| 3| 5| 3| 3| 1| 3| 3| 4| 3| 3| 3| 4| 3| 3| 3| 5| 3| |
| 6| 5| 7| 9| 7| 9| 5| 3| 5| 6| 7| 4| 6| 7| 5| 1| 6| 5| 6| 6| 5| 4| 7| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Mediastinum, Necrosis | | 1 2.0|
Perivascular, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Olfactory Epithelium, Atrophy, Focal | 1 1 | 6 1.0|
Olfactory Epithelium, Degeneration | 1 1 2 1 1 1 1 1 1| 22 1.1|
Olfactory Epithelium, Metaplasia | 1 | 2 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 1 1 1 2 2 2 1 1 2 1 2 1 1 1 1 2 2 1 2| 39 1.5|
__________________________________________________________________________|____________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | | 1 4.0|
Metaplasia, Osseous | 1| 2 1.0|
Nephropathy | 1 1 1 2 | 5 1.2|
Renal Tubule, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + I + + + + + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | 2 2 | 2 2.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 0| 7| 7| 5| 6| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 6| 3| 2| 5| 6| 3| 3| 4| 3| 0| 3| 3| 3| 9| 6| 6| 3| 3| 3| 1| 3| 0| 3|
| 3| 5| 5| 4| 7| 3| 9| 4| 4| 8| 7| 2| 5| 4| 7| 8| 8| 5| 4| 5| 5| 6| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + I + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + I + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X X X X X|
Hematopoietic Cell Proliferation | 2 2 |
Mixed Cell Focus | X |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Suppurative | 4 |
Fat, Hemorrhage | |
Fat, Necrosis | 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | 3 |
Basophilic Focus | X|
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + + + + + + M M + + + + + M + M + M M|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 0| 7| 7| 5| 6| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 6| 3| 2| 5| 6| 3| 3| 4| 3| 0| 3| 3| 3| 9| 6| 6| 3| 3| 3| 1| 3| 0| 3|
| 3| 5| 5| 4| 7| 3| 9| 4| 4| 8| 7| 2| 5| 4| 7| 8| 8| 5| 4| 5| 5| 6| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 4 2 1 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + I + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + M M + M M + + + + + + M + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 2 2 2 2 3 |
Cyst | 4 2 1 1 1 2 2 |
Hyperplasia, Tubular | 1 |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 2 |
Angiectasis | 2 3 |
Hemorrhage | 2 |
Hydrometra | 3 2 3 |
Hyperplasia, Cystic | 3 2 |
Thrombosis | |
Myometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Hyperplasia | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Renal, Hematopoietic Cell | |
Proliferation | |
Renal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + I M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + + + + M M + + + + + M + + + + + +|
Hyperplasia | 4 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M M + M M + + + + M + M + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 0| 7| 7| 5| 6| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 6| 3| 2| 5| 6| 3| 3| 4| 3| 0| 3| 3| 3| 9| 6| 6| 3| 3| 3| 1| 3| 0| 3|
| 3| 5| 5| 4| 7| 3| 9| 4| 4| 8| 7| 2| 5| 4| 7| 8| 8| 5| 4| 5| 5| 6| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 2 2 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + + + + M + + + + + + I +|
Atrophy | 3 |
Hyperplasia, Lymphoid | 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 2 1 1 1 3|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 3 2 1 4 4 1 |
Inflammation, Chronic | 2 |
Pigmentation, Hemosiderin | 1 |
Alveolar Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
Inflammation, Suppurative | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 |
Olfactory Epithelium, Degeneration | 3 3 3 3 3 3 1 2 3 2 3 3 3 3 3 2 3 3 2 3 2 2 3 3 3|
Olfactory Epithelium, Metaplasia | 2 2 2 2 3 2 1 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 0| 7| 7| 5| 6| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 6| 3| 2| 5| 6| 3| 3| 4| 3| 0| 3| 3| 3| 9| 6| 6| 3| 3| 3| 1| 3| 0| 3|
| 3| 5| 5| 4| 7| 3| 9| 4| 4| 8| 7| 2| 5| 4| 7| 8| 8| 5| 4| 5| 5| 6| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + |
Inflammation | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Metaplasia, Osseous | 1 1 1 |
Nephropathy | 1 1 1 1 1 |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + I + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 7| 8| 2| 3| 3| 3| 3| 9| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| |
| 1| 4| 7| 8| 7| 2| 0| 1| 5| 7| 6| 3| 3| 4| 6| 6| 4| 6| 7| 9| 7| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + M A + A + + + + + + + + + + + + + + + + M + +| 45 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + A + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + A + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + A + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Eosinophilic Focus | X X X X X X | 11 |
Hematopoietic Cell Proliferation | | 2 2.0|
Mixed Cell Focus | | 1 |
Necrosis | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Inflammation, Suppurative | | 1 4.0|
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 2 2 | 5 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 3.0|
Basophilic Focus | | 1 |
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 4 4| 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + A + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation | | 1 1.0|
Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1| 19 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hypertrophy | 1 1 1| 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 7| 8| 2| 3| 3| 3| 3| 9| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| |
| 1| 4| 7| 8| 7| 2| 0| 1| 5| 7| 6| 3| 3| 4| 6| 6| 4| 6| 7| 9| 7| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + M + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + A M + M M M + + + + + + + M + + + M + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 2 2 2 1 1 | 11 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 3 4 | 3 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + M + + M + M + + + + + + + + + + M| 39 |
__________________________________________________________________________|____________|
Ovary | + + + + + A + + + + + I + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Atrophy | 2 2 2 1 2 2 2 2 | 14 2.0|
Cyst | 2 2 2 1 2 2 4 2 2| 16 2.0|
Hyperplasia, Tubular | 2 | 2 1.5|
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Adenomyosis | | 1 2.0|
Angiectasis | 4 1| 4 2.5|
Hemorrhage | | 1 2.0|
Hydrometra | 2 3 | 5 2.6|
Hyperplasia, Cystic | 4 | 3 3.0|
Thrombosis | 4 3 | 2 3.5|
Myometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + +| 5 |
Hyperplasia | 2 | 1 2.0|
Iliac, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Renal, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 7| 8| 2| 3| 3| 3| 3| 9| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| |
| 1| 4| 7| 8| 7| 2| 0| 1| 5| 7| 6| 3| 3| 4| 6| 6| 4| 6| 7| 9| 7| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + + A + M + + + M + + M M + + + I + + + + +| 40 |
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + A M + M M + + + + + + M + + + M + + + +| 38 |
Hyperplasia | 2 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + A + + + + + + + + + + M + + + + + + + +| 46 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + A + + + M M + + M M + + + + + + M I + +| 35 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 10 2.1|
Hyperplasia, Lymphoid | 2 | 6 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + A + M + + + M + + + M + + + + M + + + +| 41 |
Atrophy | 2 | 2 2.5|
Hyperplasia, Lymphoid | 1 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 1 1 3 1 1 1 1 2 1 | 18 1.4|
Hyperostosis | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 6 2.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 7| 8| 2| 3| 3| 3| 3| 9| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| |
| 1| 4| 7| 8| 7| 2| 0| 1| 5| 7| 6| 3| 3| 4| 6| 6| 4| 6| 7| 9| 7| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 3 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 3.0|
Inflammation, Suppurative | 1 1 | 4 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 3 1.7|
Olfactory Epithelium, Degeneration | 3 3 3 2 2 2 3 3 2 3 3 3 2 3 2 3 3 3 3 2 3 2 3 2 3| 50 2.7|
Olfactory Epithelium, Metaplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2| 46 1.9|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 2| 5 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 3 | 1 3.0|
Metaplasia, Osseous | | 3 1.0|
Nephropathy | 1 1 | 7 1.0|
Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + A + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3|
| 6| 7| 6| 7| 5| 6| 6| 4| 8| 6| 6| 5| 7| 4| 1| 4| 5| 4| 6| 6| 4| 7| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + I + + + + + M + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 2 3 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Basophilic Focus | |
Necrosis | |
Duct, Cyst | 3 |
Duct, Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Ulcer | 1 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 1 |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3|
| 6| 7| 6| 7| 5| 6| 6| 4| 8| 6| 6| 5| 7| 4| 1| 4| 5| 4| 6| 6| 4| 7| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Cystic | 2 3 |
Hyperplasia | |
Hypertrophy | 2 1 |
Capsule, Hyperplasia | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + I + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + M + M + M + + + + M + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 2 3 3 2 2 2 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + I + + M + + + + + I + + I + M + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 2 2 2 2 1|
Cyst | 2 4 2 1 2 2 |
Thrombosis | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 3 3 3 2 2 |
Hyperplasia, Cystic | 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia | 2 |
Pancreatic, Hyperplasia | 4 |
Renal, Hyperplasia | 4 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + + + + + + + + + + M + M + + + + M M +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + M + + + + + + + + + + + M + +|
Hyperplasia | 2 3 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + M + + + + + + + M + + + M + + M +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3|
| 6| 7| 6| 7| 5| 6| 6| 4| 8| 6| 6| 5| 7| 4| 1| 4| 5| 4| 6| 6| 4| 7| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 2 3 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 2 2 4 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2|
Infiltration Cellular, Histiocyte | 2 2 4 |
Inflammation, Chronic | 1 |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | 3 |
Mediastinum, Inflammation, Chronic | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Glands, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Olfactory Epithelium, Degeneration | 4 3 3 4 3 4 3 3 3 4 3 4 3 4 4 3 3 3 3 4 4 3 4 2 3|
Olfactory Epithelium, Metaplasia | 2 2 2 2 2 2 2 3 2 2 2 3 2 2 3 2 2 2 1 3 2 2 2 1 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 3 2 2 2 3 3 3 2 3 2 3 2 3 2 3 2 3 2 3 2 2 3 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3|
| 6| 7| 6| 7| 5| 6| 6| 4| 8| 6| 6| 5| 7| 4| 1| 4| 5| 4| 6| 6| 4| 7| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | 1 1 1 |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 5| 3| 0| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 6| 6| 9| 7| 6| 3| 6| 1| 4| 9| 7| 7| 2| 6| 5| 7| 4| 5| 3| 4| 5| 6| 7| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
750 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + A + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + A + + + + + + + + + + + + + + + + +| 48 |
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Basophilic Focus | | 1 |
Eosinophilic Focus | X X X X X X X X | 15 |
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Mixed Cell Focus | X | 1 |
Vacuolization Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Fat, Necrosis | 2 4 4 3 2 | 10 2.7|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 2 4.0|
Basophilic Focus | X| 1 |
Necrosis | 1 | 1 1.0|
Duct, Cyst | 3 | 2 3.0|
Duct, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Hyaline | | 1 1.0|
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 5| 3| 0| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 6| 6| 9| 7| 6| 3| 6| 1| 4| 9| 7| 7| 2| 6| 5| 7| 4| 5| 3| 4| 5| 6| 7| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
750 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1| 18 1.0|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 | 3 2.3|
Hyperplasia | 2 4 | 2 3.0|
Hypertrophy | 1 | 3 1.3|
Capsule, Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + M + M + + M I M M M + + + + M + +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 1 3 1 2 4 1 3 | 18 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + M + + M + M + + M + + M M + + + M| 36 |
__________________________________________________________________________|____________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 2 2 1 2 2 2 2| 13 1.8|
Cyst | 4 2 4 2 2 2 2 | 13 2.4|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 4 2 2 | 10 2.6|
Hyperplasia, Cystic | 4| 2 3.5|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Iliac, Hyperplasia | | 1 2.0|
Pancreatic, Hyperplasia | | 1 4.0|
Renal, Hyperplasia | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 5| 3| 0| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 6| 6| 9| 7| 6| 3| 6| 1| 4| 9| 7| 7| 2| 6| 5| 7| 4| 5| 3| 4| 5| 6| 7| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
750 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M M + + + + M + + M + + + + + + + +| 40 |
Hyperplasia | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + M + + + + + + + + M + M +| 43 |
Hyperplasia | 2 | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + I + + + + + + + + + + +| 48 |
Angiectasis | 2 2 | 2 2.0|
Hyperplasia | 2 2| 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + + M + + + + + + M + + + M + +| 41 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 4 2 2 2 2 2 2 | 12 2.3|
Hyperplasia, Lymphoid | 2 | 8 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + M + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 4 | 5 2.8|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 2 2 1 1 1| 12 1.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 2 3.0|
Infiltration Cellular, Histiocyte | 3 | 4 2.8|
Inflammation, Chronic | | 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Mediastinum, Inflammation, Chronic | 1 | 1 1.0|
Perivascular, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 5| 3| 0| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 6| 6| 9| 7| 6| 3| 6| 1| 4| 9| 7| 7| 2| 6| 5| 7| 4| 5| 3| 4| 5| 6| 7| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
750 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Glands, Hyperplasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 3 2.0|
Olfactory Epithelium, Degeneration | 3 3 3 3 3 3 4 2 3 3 3 4 2 3 4 3 2 3 2 3 4 2 4 3 3| 50 3.2|
Olfactory Epithelium, Metaplasia | 2 2 2 2 2 4 2 2 3 3 2 2 3 2 2 3 1 2 2 2 3 2 2| 48 2.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 3 2 2 3 2 3 3 2 3 2 3 4 2 2 3 2 2 3 3 2 3 2 3 3 3| 50 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 2.0|
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1| 7 1.0|
Renal Tubule, Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 4| 3| 3| 0| 1| 3| 3| 3| 3| 0| 3|
| 4| 3| 5| 6| 6| 5| 5| 4| 4| 4| 6| 3| 1| 6| 5| 5| 5| 3| 4| 4| 6| 7| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + A + + + + + +|
Degeneration, Hyaline | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + A + + A + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X |
Mixed Cell Focus | X |
Necrosis | 3 |
Bile Duct, Cyst | |
Bile Duct, Degeneration | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | |
Infiltration Cellular, Mast Cell | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 2 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
Hypertrophy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + + M + M M + M|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 4| 3| 3| 0| 1| 3| 3| 3| 3| 0| 3|
| 4| 3| 5| 6| 6| 5| 5| 4| 4| 4| 6| 3| 1| 6| 5| 5| 5| 3| 4| 4| 6| 7| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 2 1 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | 3 3 2 |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | |
Iliac, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + + M + + + + M M + M M + M + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + M + + M + + + M + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | 2 1 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M + M + + + M M + + M M M + + M + + M + M|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M M + + + I M + + M + + M M + + + M + + M + M +|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 4| 3| 3| 0| 1| 3| 3| 3| 3| 0| 3|
| 4| 3| 5| 6| 6| 5| 5| 4| 4| 4| 6| 3| 1| 6| 5| 5| 5| 3| 4| 4| 6| 7| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 4 |
Prepuce, Inflammation, Suppurative | 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 3 |
Alveolar Epithelium, Hyperplasia | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
Olfactory Epithelium, Atrophy, Focal | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 2 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 3 |
Renal Tubule, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 6| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 5| 3| 0| 4| 3| 3| 6| 2| 8| 5| 3| 3| |
| 5| 4| 7| 4| 4| 0| 5| 6| 6| 4| 9| 5| 4| 3| 7| 1| 9| 6| 4| 5| 3| 1| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | I + + + + A + M + + A + M + + + + + + + + + + + +| 43 |
Degeneration, Hyaline | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + M + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + A + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | X X X X | 11 |
Mixed Cell Focus | | 1 |
Necrosis | 4 4 4 | 4 3.8|
Bile Duct, Cyst | 3 | 1 3.0|
Bile Duct, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 4 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 2 1.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + A + + + + + + + + + + + + + +| 48 |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Developmental Malformation | X X | 2 |
Infiltration Cellular, Mast Cell | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 2 1 2 1 | 20 1.2|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 3 2 1 | 4 2.0|
Hypertrophy | 1 2 2 1 1 1 1 1| 22 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 6| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 5| 3| 0| 4| 3| 3| 6| 2| 8| 5| 3| 3| |
| 5| 4| 7| 4| 4| 0| 5| 6| 6| 4| 9| 5| 4| 3| 7| 1| 9| 6| 4| 5| 3| 1| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 2 | 5 1.4|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + M M + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 1 | 9 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 2 | 5 2.6|
Inflammation, Chronic | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 | 4 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
Iliac, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M M A M M M + + M M + + + + M M + M + + M M| 26 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + M + + M + M M + +| 40 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + M + + + +| 47 |
Angiectasis | | 3 1.7|
Hyperplasia | 2 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 6| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 5| 3| 0| 4| 3| 3| 6| 2| 8| 5| 3| 3| |
| 5| 4| 7| 4| 4| 0| 5| 6| 6| 4| 9| 5| 4| 3| 7| 1| 9| 6| 4| 5| 3| 1| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + A + + + + + + + + + + M + + + + M + + +| 35 |
Hyperplasia | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + I M + + M + M M + + + + + M + + M + + + +| 33 |
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 4 4 | 5 3.6|
Prepuce, Inflammation, Suppurative | 4 4 4 4 | 6 3.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 4 2 1 3 2 | 7 2.4|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Perivascular, Inflammation, Chronic | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.5|
Olfactory Epithelium, Atrophy, Focal | 1 1 | 3 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 6| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 5| 3| 0| 4| 3| 3| 6| 2| 8| 5| 3| 3| |
| 5| 4| 7| 4| 4| 0| 5| 6| 6| 4| 9| 5| 4| 3| 7| 1| 9| 6| 4| 5| 3| 1| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 4 2 2 | 4 2.3|
Inflammation, Suppurative | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 1 1 1 1 2 1 1 1 1 2 2 1 1 2 1 1 | 35 1.3|
Renal Tubule, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + A + + + + + + + + + + + + + +| 48 |
Calculus Gross Observation | | 1 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3|
| 4| 6| 5| 6| 1| 4| 5| 4| 6| 4| 5| 5| 6| 8| 7| 5| 5| 8| 6| 1| 4| 7| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + A +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X|
Hematopoietic Cell Proliferation | 2 |
Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + A +|
Inflammation | |
Ulcer | 3 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
Hypertrophy | 2 1 1 1 1 1 1 3 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + M M + + + + I + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3|
| 4| 6| 5| 6| 1| 4| 5| 4| 6| 4| 5| 5| 6| 8| 7| 5| 5| 8| 6| 1| 4| 7| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
__________________________________________________________________________|
Penis | + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 |
Inflammation, Chronic | 2 2|
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + I M + + + M + M M + + + M M M + M + M + + M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + M + + + + + M + + M + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + M + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + M + + + M + + M + + + + + + + + + + + M|
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis, Focal | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 1 3 |
Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Thymus | + M + + + + + + M M M + M + + + M M + + + + M + M|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Prepuce, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3|
| 4| 6| 5| 6| 1| 4| 5| 4| 6| 4| 5| 5| 6| 8| 7| 5| 5| 8| 6| 1| 4| 7| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 4 2 |
Inflammation, Chronic | 1 |
Pigmentation, Hemosiderin | 4 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Suppurative | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 |
Olfactory Epithelium, Atrophy, Focal | |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 3| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 5| 7| 3| 2| 3| 7| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 7| 5| 6| 7| 5| 5| 9| 7| 4| 6| 9| 9| 5| 0| 7| 8| 4| 7| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X | 8 |
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Necrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation | 2 | 1 2.0|
Ulcer | 2 | 2 2.5|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Developmental Malformation | X | 2 |
Dysplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 2 1 1 | 20 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 2.0|
Hypertrophy | 1 1 1 2 2 2 1 1 1 1 3 1 1 | 22 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M + M M + + + + M + M M + + + M + M| 34 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 3| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 5| 7| 3| 2| 3| 7| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 7| 5| 6| 7| 5| 5| 9| 7| 4| 6| 9| 9| 5| 0| 7| 8| 4| 7| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 4.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
Inflammation, Suppurative | 3 | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 2.3|
Inflammation, Chronic | 2| 3 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M M + M M + + M + + + M M M M + + + M + + M| 26 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + M M M + + + + + M M M| 39 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + M + + + + + + + + + + + + +| 46 |
Angiectasis | 1 | 2 1.5|
Hyperplasia | 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M + + + + + + + + + M M M M + + M + M +| 37 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 3| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 5| 7| 3| 2| 3| 7| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 7| 5| 6| 7| 5| 5| 9| 7| 4| 6| 9| 9| 5| 0| 7| 8| 4| 7| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 4 2 2 | 9 2.2|
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + M M + + + M M + + M + M| 34 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 | 1 4.0|
Prepuce, Inflammation, Suppurative | 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | | 2 3.0|
Inflammation, Chronic | | 1 1.0|
Pigmentation, Hemosiderin | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 1 1 | 5 1.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 3 1.3|
Olfactory Epithelium, Atrophy, Focal | 1 1 2 1 1 1 1 1| 8 1.1|
Olfactory Epithelium, Degeneration | 1 2 1 1 | 10 1.1|
Olfactory Epithelium, Metaplasia | 2 | 1 2.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 1 1 1 | 5 1.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 3| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 5| 7| 3| 2| 3| 7| 3| 3| 3| 4| 3| 3| |
| 5| 5| 5| 7| 5| 6| 7| 5| 5| 9| 7| 4| 6| 9| 9| 5| 0| 7| 8| 4| 7| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 2.0|
Inflammation, Suppurative | 2 4 2 | 4 2.5|
Metaplasia, Osseous | 1 1 | 4 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 34 1.0|
Cortex, Cyst | | 1 2.0|
Renal Tubule, Hyperplasia | 1 | 5 1.2|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 3 3 | 4 3.3|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 0| 3| 9| 3| 3|
| 5| 4| 6| 5| 3| 6| 4| 3| 7| 4| 7| 6| 7| 6| 6| 7| 4| 6| 1| 5| 5| 4| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X X X |
Inflammation, Chronic | 2 |
Necrosis | 4 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 |
Mineralization | 2 |
Artery, Thrombosis | |
Endothelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Degeneration | |
Hemorrhage | 2 |
Hyperplasia | 3 1 2 |
Hypertrophy | 2 2 2 1 1 1 1 1 2 2 2|
Capsule, Hyperplasia | 3 4 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 0| 3| 9| 3| 3|
| 5| 4| 6| 5| 3| 6| 4| 3| 7| 4| 7| 6| 7| 6| 6| 7| 4| 6| 1| 5| 5| 4| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + + + + + + + M + M + M + M + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Penis | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | 3 2 |
Inflammation, Chronic | 2 2 |
Bilateral, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + A + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 |
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M + + M + M M M + M + M + M M M M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M + + + + + + M + + + + + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + M + + + + + + + + + + M + + + + + +|
Congestion | 1 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + M M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 0| 3| 9| 3| 3|
| 5| 4| 6| 5| 3| 6| 4| 3| 7| 4| 7| 6| 7| 6| 6| 7| 4| 6| 1| 5| 5| 4| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M + M M I M I + + + + + + + + + + + M M + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Prepuce, Inflammation, Suppurative | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 3 2 |
Pigmentation, Hemosiderin | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
Olfactory Epithelium, Degeneration | 2 2 2 3 3 3 3 3 3 2 2 3 3 2 3 3 3 3 2 2 2 3 2 3 3|
Olfactory Epithelium, Metaplasia | 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +|
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation | 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 0| 3| 9| 3| 3|
| 5| 4| 6| 5| 3| 6| 4| 3| 7| 4| 7| 6| 7| 6| 6| 7| 4| 6| 1| 5| 5| 4| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Amyloid Deposition | |
Hydronephrosis | |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 2 1 1|
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Mineralization | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 4| 5| 7| 7| 3| 5| 5| 7| 7| 3| 7| 7| 7| 5| 6| 6| 7| 6| |
DAY ON TEST | 3| 3| 0| 8| 3| 9| 3| 3| 6| 3| 3| 3| 7| 8| 3| 3| 7| 3| 3| 2| 2| 4| 5| 3| 7| |
| 6| 6| 7| 1| 7| 2| 5| 6| 3| 4| 4| 1| 6| 1| 7| 7| 7| 6| 7| 6| 0| 5| 5| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + M + + M + + + + + M + + I + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + A + +| 47 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + A + +| 47 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + A + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 3 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X | 9 |
Inflammation, Chronic | 2 | 2 2.0|
Necrosis | 2 4 | 3 3.3|
Bile Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Inflammation, Chronic | 4 | 1 4.0|
Fat, Necrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 1 1 3 | 4 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 2 1 2 2 2 1 2 1 | 20 1.4|
Mineralization | | 1 2.0|
Artery, Thrombosis | 2 | 1 2.0|
Endothelium, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 4| 5| 7| 7| 3| 5| 5| 7| 7| 3| 7| 7| 7| 5| 6| 6| 7| 6| |
DAY ON TEST | 3| 3| 0| 8| 3| 9| 3| 3| 6| 3| 3| 3| 7| 8| 3| 3| 7| 3| 3| 2| 2| 4| 5| 3| 7| |
| 6| 6| 7| 1| 7| 2| 5| 6| 3| 4| 4| 1| 6| 1| 7| 7| 7| 6| 7| 6| 0| 5| 5| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | 1 1 2 | 6 1.7|
Hypertrophy | 3 1 2 1 3 1 1 2| 19 1.6|
Capsule, Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + + + + + + + M M + + + + + + M + + M +| 38 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + M + + + + +| 46 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + + | 3 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 2 2.5|
Inflammation, Chronic | 2 4 3 | 5 2.6|
Bilateral, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 4 1.8|
Inflammation, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 4| 5| 7| 7| 3| 5| 5| 7| 7| 3| 7| 7| 7| 5| 6| 6| 7| 6| |
DAY ON TEST | 3| 3| 0| 8| 3| 9| 3| 3| 6| 3| 3| 3| 7| 8| 3| 3| 7| 3| 3| 2| 2| 4| 5| 3| 7| |
| 6| 6| 7| 1| 7| 2| 5| 6| 3| 4| 4| 1| 6| 1| 7| 7| 7| 6| 7| 6| 0| 5| 5| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M + + + + + M + + + + + + + + M + + M + M +| 24 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + M + M + + + M M + + + + + + + + + M M + +| 37 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Congestion | | 1 1.0|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M + + + M + + + M M M + + + M + + M M M + M| 36 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 | 11 2.0|
__________________________________________________________________________|____________|
Thymus | M + M + + M + + + M M + + + + M + + + + + M + + +| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + I + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 4 | 2 3.0|
Prepuce, Inflammation, Suppurative | 4 4 4 4 4 4 | 8 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 3 | 3 2.7|
Pigmentation, Hemosiderin | 2 1 | 3 1.3|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 3 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 2 3 1 2 2 2| 10 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 4| 5| 7| 7| 3| 5| 5| 7| 7| 3| 7| 7| 7| 5| 6| 6| 7| 6| |
DAY ON TEST | 3| 3| 0| 8| 3| 9| 3| 3| 6| 3| 3| 3| 7| 8| 3| 3| 7| 3| 3| 2| 2| 4| 5| 3| 7| |
| 6| 6| 7| 1| 7| 2| 5| 6| 3| 4| 4| 1| 6| 1| 7| 7| 7| 6| 7| 6| 0| 5| 5| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Degeneration | 3 3 4 2 2 3 3 2 2 3 3 2 2 2 2 3 2 3 3 2 2 2 2 3 2| 50 2.5|
Olfactory Epithelium, Metaplasia | 2 2 2 1 1 2 2 2 2 1 2 2 2 1 1 1 2 1| 41 1.8|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 1 2 1 1 2 1 2 2 2 2 2 2 2 2| 50 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Inflammation | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 6 1.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 4 | 1 4.0|
Hydronephrosis | 1 2 1 | 3 1.3|
Inflammation, Suppurative | 1 | 2 1.5|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 | 33 1.1|
Cortex, Cyst | | 1 2.0|
Renal Tubule, Hyperplasia | 1 | 2 1.0|
Renal Tubule, Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Suppurative | 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 4| 7| 3| 3| 5| 3| 3| 3| 3| 0| 7| 0| 3| 3| 3| 9| 9| 3| 3| 3| 3|
| 5| 9| 4| 5| 9| 9| 2| 4| 9| 5| 7| 6| 7| 6| 1| 9| 7| 5| 4| 9| 9| 5| 7| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + A + + + + + I + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + I + A + + + + + + + + A I + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X|
Eosinophilic Focus | X X X X X |
Inflammation, Chronic | 1 |
Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Angiectasis | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 2 2 2|
Hypertrophy | 1 1 2 1 1 1 1 2 1 1 1 1 |
Capsule, Hyperplasia | 4 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + M + + + + M + + + M M + + + +|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + A + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 4| 7| 3| 3| 5| 3| 3| 3| 3| 0| 7| 0| 3| 3| 3| 9| 9| 3| 3| 3| 3|
| 5| 9| 4| 5| 9| 9| 2| 4| 9| 5| 7| 6| 7| 6| 1| 9| 7| 5| 4| 9| 9| 5| 7| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + A + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cyst | 3 4 2 |
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + A + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | |
Iliac, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + M + + + + M M M + + M M + + + M + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + I + + + + + + A + + + + + + + + + + +|
Hyperplasia | 4 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + + + + M + + M + + + M M + M + + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + M + + + + M + + M + + + + + M +|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + M + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 4| 7| 3| 3| 5| 3| 3| 3| 3| 0| 7| 0| 3| 3| 3| 9| 9| 3| 3| 3| 3|
| 5| 9| 4| 5| 9| 9| 2| 4| 9| 5| 7| 6| 7| 6| 1| 9| 7| 5| 4| 9| 9| 5| 7| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 4 |
Alveolar Epithelium, Hyperplasia | 3 |
Mediastinum, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 2 2 2 2 |
Olfactory Epithelium, Degeneration | 2 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3|
Olfactory Epithelium, Metaplasia | 1 2 2 2 2 1 2 2 2 2 2 3 2 1 2 1 2 2 2 2 3 2 2 3 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Inflammation | 4 2 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 3 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1|
Pelvis, Necrosis | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Ureter | |
Inflammation, Suppurative | |
Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 0| 9| 2| 3| 3| 3| 9| 3| 3| 3| 9| 5| 8| 3| 3| 9| 3| 8| 3| 3| |
| 4| 5| 5| 3| 4| 4| 5| 6| 7| 7| 4| 6| 6| 7| 6| 7| 1| 6| 4| 7| 9| 7| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
750 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + I + + + + + + + + + + + + + I +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + M + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + A + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Clear Cell Focus | X X X X| 8 |
Eosinophilic Focus | X X X X X X | 11 |
Inflammation, Chronic | | 1 1.0|
Necrosis | 1 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 2 1 1 2 1 | 19 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + I + + + + +| 48 |
Hyperplasia | 2 4 | 6 2.3|
Hypertrophy | 1 1 1 1 1 1 3 1 1 1| 22 1.2|
Capsule, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + M + + + + +| 47 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + M + + + + + + + + M M + + + + + M + + +| 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 0| 9| 2| 3| 3| 3| 9| 3| 3| 3| 9| 5| 8| 3| 3| 9| 3| 8| 3| 3| |
| 4| 5| 5| 3| 4| 4| 5| 6| 7| 7| 4| 6| 6| 7| 6| 7| 1| 6| 4| 7| 9| 7| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
750 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 2| 4 2.8|
Inflammation, Chronic | 4 1 | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + A + + + + + I + + + + + + + + + M + + +| 46 |
Inflammation, Suppurative | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Iliac, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + + M M M M + + M + M + + + M + M M M M| 28 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + I + + + + + + + + M + + + + + + + M + + M +| 43 |
Hyperplasia | 2 | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + + M| 40 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + M + + M + M + + + + + + M + +| 40 |
Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 0| 9| 2| 3| 3| 3| 9| 3| 3| 3| 9| 5| 8| 3| 3| 9| 3| 8| 3| 3| |
| 4| 5| 5| 3| 4| 4| 5| 6| 7| 7| 4| 6| 6| 7| 6| 7| 1| 6| 4| 7| 9| 7| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
750 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + M + + + I + + + + + + + + + + + + + + +| 48 |
Prepuce, Inflammation, Suppurative | 4 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 3 2 2 3 | 6 2.7|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Mediastinum, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 2 | 10 1.9|
Olfactory Epithelium, Degeneration | 4 3 3 2 4 3 3 2 3 4 4 3 3 3 3 3 3 2 3 3 3 4 3 3 3| 50 3.1|
Olfactory Epithelium, Metaplasia | 3 2 2 2 2 2 2 2 3 3 1 2 3 2 2 2 1 2 2 2 3 2 2 2| 49 2.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2| 50 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
Inflammation | 4 | 4 3.3|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 4 | 2 3.5|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 2 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1| 41 1.1|
Pelvis, Necrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05200-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 08/10/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:12:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 0| 9| 2| 3| 3| 3| 9| 3| 3| 3| 9| 5| 8| 3| 3| 9| 3| 8| 3| 3| |
| 4| 5| 5| 3| 4| 4| 5| 6| 7| 7| 4| 6| 6| 7| 6| 7| 1| 6| 4| 7| 9| 7| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
750 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 4 4 3 | 3 3.7|
Transitional Epithelium, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
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---------- END OF REPORT ----------
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