TDMS Study 05200-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest NITROMETHANE DATE: 04/04/96
EXPERIMENT: 05200 TEST: 06 TIME: 06:25:01
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-75189 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61927
PATHOLOGIST: R. MILLER R. RENNE CAS: 75-52-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest NITROMETHANE DATE: 04/04/96
EXPERIMENT: 05200 TEST: 06 TIME: 06:25:01
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75189 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61927
PATHOLOGIST: R. MILLER R. RENNE CAS: 75-52-5
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 441 449 490 503 503 534 545 576 581 609 |
| 623 653 653 653 653 665 701 714 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 188 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 320 448 479 484 578 646 659 665 679 707 |
| 721 721 728 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 375 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 331 377 436 498 520 534 541 563 576 581 |
| 581 592 645 655 679 693 705 707 726 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 750 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 393 406 497 551 586 595 596 609 632 649 |
| 659 665 671 679 679 688 699 699 699 704 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 96.0 86.0 82.0 68.0 62.0 |
| | |
| | |
|188 PPM | 100.0 100.0 100.0 98.0 98.0 92.0 92.0 90.0 84.0 72.0 |
| | |
| | |
|375 PPM | 100.0 100.0 100.0 98.0 96.0 94.0 86.0 76.0 72.0 60.0 |
| | |
| | |
|750 PPM | 100.0 100.0 100.0 100.0 96.0 96.0 94.0 86.0 76.0 58.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 188 PPM 375 PPM 750 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 72.0% 60.0% 58.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.519 P=0.321N P=0.960 P=0.949 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 593.5 611.9 583.7 623.0 |
|NATURAL DEATHS (C) | (20.4) (34.6) (25.5) (20.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 680.6 699.8 673.9 687.4 |
|(STANDARD ERROR) | (12.4) (12.3) (14.5) (11.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 2 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 301 376 385 401 574 576 597 609 617 618 |
| 632 632 657 663 667 667 681 693 693 693 |
| 707 707 716 |
| CENSORED DEATHS |
| 436 436 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 188 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 345 357 416 426 441 534 555 564 569 569 |
| 579 581 637 639 646 653 656 663 665 693 |
| 693 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 375 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 1 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 69 498 548 568 572 602 608 609 631 637 |
| 637 646 653 665 665 679 680 693 693 716 |
| 721 727 733 |
| CENSORED DEATHS |
| 296 |
| |
==================================================================================
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 750 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 51 426 503 553 603 632 638 657 687 699 |
| 706 716 721 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 92.0 92.0 92.0 85.7 71.1 52.3 |
| | |
| | |
|188 PPM | 100.0 100.0 100.0 96.0 94.0 90.0 88.0 76.0 62.0 56.0 |
| | |
| | |
|375 PPM | 98.0 98.0 98.0 98.0 98.0 98.0 96.0 87.8 69.4 53.1 |
| | |
| | |
|750 PPM | 98.0 98.0 98.0 98.0 98.0 96.0 94.0 90.0 84.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 188 PPM 375 PPM 750 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.3% 56.0% 53.1% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.046N P=1.000N P=0.993N P=0.056N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 602.7 573.3 619.6 594.4 |
|NATURAL DEATHS (C) | (24.9) (23.8) (28.0) (48.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 661.7 663.3 672.6 694.9 |
|(STANDARD ERROR) | (16.0) (15.4) (16.9) (15.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NITROMETHANE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
188 PPM = 2
375 PPM = 3
750 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 2 3 4 1
| 2 3 3 44 12 1
P 96 + 3 4 32 1 214
E | 3 2141 4
R | 2 3 3 4 24
C | 1 3 1 24 4 2
E 88 + 11 44 2 2
N | 1 3 1 44
T | 3 3 4 4 2 2
| 1 1 4 4 2 2
S 80 + 1 1 4 4 2 2
U | 3 3 1 1
R | 3 3 44 22
V | 33 44 2 2
I 72 + 3 3 2
V | 1 1 3 3
A | 1 341
L | 11
64 + 31 3 1
| 44 3 1
| 4 4 3
| 4 4
56 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
NITROMETHANE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
188 PPM = 2
375 PPM = 3
750 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 3 1 2
|
| 4 3 1 22 1 4 3
| 2 1 1 24 3 3
95 +
| 1 1 22 4 3 3
| 1 2 2 4 1 4
|
90 + 2 2 11 34 4
|
| 2 2 1 13 44
| 22 11 4 4
P 85 +
E | 22 1 1 3 4 4
R | 44
C |
E 80 + 22 1 1 44
N |
T | 3 3 4 4
| 2 2
S 75 + 1 31
U | 22 1 1 4 4
R | 22 4
V | 11
I 70 + 22 3 3
V |
A | 131
L | 2 2
65 + 11
|
| 2 2
| 3 3
60 +
| 1 1
| 2 33 2
| 2
55 + 3 3
| 1 1
| 1 1
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.