TDMS Study 05200-05 Pathology Tables
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
Facility: Battelle Northwest
Chemical CAS #: 75-52-5
Lock Date: 06/22/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 5 5 2 2
Moribund Sacrifice 17 26 18 25
Survivors
Terminal Sacrifice 28 19 30 23
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 1 (2%) 4 (8%) 5 (10%)
Basophilic Focus 41 (82%) 42 (84%) 41 (82%) 41 (82%)
Clear Cell Focus 6 (12%) 9 (18%) 9 (18%) 7 (14%)
Degeneration, Cystic 1 (2%) 1 (2%)
Degeneration, Fatty 9 (18%) 7 (14%) 8 (16%) 5 (10%)
Eosinophilic Focus 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 7 (14%) 4 (8%) 3 (6%) 5 (10%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mixed Cell Focus 12 (24%) 15 (30%) 11 (22%) 17 (34%)
Necrosis 1 (2%) 1 (2%)
Regeneration 2 (4%)
Bile Duct, Hyperplasia 10 (20%) 7 (14%) 12 (24%) 9 (18%)
Centrilobular, Necrosis 1 (2%)
Mesentery (10) (11) (12) (14)
Fat, Necrosis 7 (70%) 10 (91%) 10 (83%) 11 (79%)
Pancreas (50) (50) (50) (50)
Atrophy 20 (40%) 15 (30%) 20 (40%) 24 (48%)
Basophilic Focus 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Artery, Inflammation 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 2 (4%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute 2 (4%) 1 (2%) 4 (8%) 1 (2%)
Mineralization 1 (2%)
Necrosis 4 (8%) 3 (6%) 5 (10%) 6 (12%)
Stomach, Glandular (50) (50) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Tooth (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 42 (84%) 31 (62%) 34 (68%) 39 (78%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 6 (12%) 15 (30%) 12 (24%) 13 (26%)
Hypertrophy 16 (32%) 12 (24%) 14 (28%) 12 (24%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%)
Adrenal Medulla (49) (50) (49) (50)
Hyperplasia 3 (6%) 4 (8%) 9 (18%) 8 (16%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 2 (4%)
Parathyroid Gland (50) (49) (50) (48)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Hyperplasia 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 13 (26%) 8 (16%) 9 (18%) 9 (18%)
Thyroid Gland (50) (50) (50) (49)
C-Cell, Hyperplasia 41 (82%) 47 (94%) 49 (98%) 42 (86%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (46) (47) (48)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 4 (9%) 6 (13%) 4 (9%) 2 (4%)
Ovary (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 1 (2%) 2 (4%) 5 (10%) 3 (6%)
Inflammation, Granulomatous 1 (2%)
Uterus (50) (50) (50) (50)
Cyst 1 (2%)
Hydrometra 1 (2%)
Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia, Reticulum Cell 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Lymph Node (7) (6) (9) (3)
Iliac, Pigmentation 1 (14%) 1 (33%)
Pancreatic, Hemorrhage 1 (17%) 1 (11%)
Pancreatic, Infiltration Cellular, Eosinophil 1 (33%)
Pancreatic, Inflammation, Granulomatous 1 (33%)
Renal, Hemorrhage 1 (14%) 1 (11%) 1 (33%)
Renal, Pigmentation 1 (11%)
Lymph Node, Bronchial (48) (49) (47) (48)
Infiltration Cellular, Eosinophil 1 (2%)
Inflammation, Granulomatous 1 (2%)
Lymph Node, Mandibular (49) (48) (48) (47)
Hemorrhage 1 (2%)
Infiltration Cellular, Plasma Cell 2 (4%) 1 (2%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Eosinophil 1 (2%)
Inflammation, Granulomatous 1 (2%)
Lymph Node, Mediastinal (48) (49) (50) (46)
Hemorrhage 1 (2%) 3 (6%) 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Spleen (50) (49) (50) (50)
Fibrosis 2 (4%) 1 (2%) 4 (8%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 3 (6%) 1 (2%) 3 (6%) 7 (14%)
Hyperplasia 1 (2%)
Hyperplasia, Atypical 12 (24%) 17 (34%) 14 (28%) 15 (30%)
Hyperplasia, Lobular 2 (4%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Skin (50) (50) (48) (49)
Hyperkeratosis 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Sebaceous Gland, Hypertrophy 1 (2%)
Vulva, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 3 (6%) 1 (2%) 1 (2%)
Cranium, Hyperostosis 1 (2%)
Femur, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Hydrocephalus 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (49)
Metaplasia, Squamous 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Fibrosis, Focal 1 (2%)
Fibrosis, Multifocal 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 11 (22%) 7 (14%) 7 (14%)
Artery, Mediastinum, Inflammation 1 (2%)
Artery, Mediastinum, Mineralization 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Metaplasia 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Chronic Active 3 (6%) 2 (4%)
Inflammation, Suppurative 4 (8%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 5 (10%) 4 (8%) 6 (12%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2) (4)
Cataract 1 (50%) 1 (50%) 3 (75%)
Degeneration 1 (50%) 1 (100%) 1 (25%)
Retina, Atrophy 1 (25%)
Harderian Gland (3)
Hemorrhage 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1 (2%) 1 (2%)
Mineralization 1 (2%)
Nephropathy 49 (98%) 49 (98%) 48 (96%) 49 (98%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (49) (50)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 33 31 34 39
Natural Death 4 3 2 3
Survivors
Terminal Sacrifice 13 16 14 8
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (50) (50) (50)
Diverticulum 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (49)
Necrosis 1 (2%) 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Diverticulum 1 (2%)
Inflammation, Acute 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 3 (6%) 3 (6%)
Basophilic Focus 16 (32%) 19 (38%) 20 (40%) 23 (46%)
Clear Cell Focus 3 (6%) 5 (10%) 10 (20%) 6 (12%)
Cyst 2 (4%) 1 (2%)
Degeneration, Cystic 19 (38%) 15 (30%) 16 (32%) 22 (44%)
Degeneration, Fatty 6 (12%) 6 (12%) 2 (4%) 8 (16%)
Eosinophilic Focus 2 (4%) 4 (8%) 4 (8%) 3 (6%)
Hepatodiaphragmatic Nodule 4 (8%) 4 (8%) 2 (4%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Mixed Cell Focus 7 (14%) 6 (12%) 9 (18%) 7 (14%)
Necrosis 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Regeneration 2 (4%) 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 44 (88%) 43 (86%) 47 (94%) 43 (86%)
Centrilobular, Necrosis 7 (14%) 1 (2%) 1 (2%) 2 (4%)
Mesentery (15) (13) (10) (8)
Infiltration Cellular 1 (8%)
Artery, Inflammation 2 (15%)
Artery, Mineralization 2 (15%) 1 (10%)
Fat, Hemorrhage 1 (8%) 1 (13%)
Fat, Necrosis 12 (80%) 7 (54%) 9 (90%) 6 (75%)
Oral Mucosa (1) (2) (1)
Gingival, Hyperplasia 1 (50%)
Gingival, Inflammation, Chronic Active 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pharyngeal, Hyperplasia, Squamous 1 (100%)
Pancreas (50) (50) (50) (50)
Atrophy 27 (54%) 28 (56%) 34 (68%) 32 (64%)
Basophilic Focus 3 (6%) 7 (14%) 3 (6%)
Hyperplasia 2 (4%) 3 (6%) 5 (10%) 4 (8%)
Hyperplasia, Focal 1 (2%)
Hypertrophy 1 (2%)
Artery, Inflammation 3 (6%)
Salivary Glands (50) (50) (50) (50)
Degeneration, Fatty 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 1 (2%)
Hyperplasia, Squamous 3 (6%) 1 (2%) 1 (2%)
Inflammation, Acute 3 (6%) 2 (4%) 8 (16%)
Mineralization 1 (2%)
Necrosis 6 (12%) 4 (8%) 3 (6%) 9 (18%)
Stomach, Glandular (50) (50) (50) (50)
Inflammation, Acute 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Mineralization 4 (8%) 2 (4%)
Necrosis 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Tooth (1) (2) (3)
Developmental Malformation 1 (33%)
Foreign Body 1 (50%)
Inflammation, Chronic Active 1 (100%) 2 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 45 (90%) 49 (98%) 47 (94%) 47 (94%)
Artery, Mineralization 1 (2%) 1 (2%)
Atrium, Thrombosis 5 (10%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Atrophy 3 (6%) 1 (2%) 2 (4%)
Hyperplasia 24 (48%) 19 (38%) 22 (44%) 22 (44%)
Hypertrophy 6 (12%) 10 (20%) 11 (22%) 8 (16%)
Necrosis 1 (2%) 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%) 4 (8%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 20 (40%) 23 (46%) 27 (54%) 22 (44%)
Necrosis 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Parathyroid Gland (47) (49) (49) (48)
Hyperplasia 8 (17%) 4 (8%) 5 (10%) 7 (15%)
Pituitary Gland (50) (47) (50) (49)
Pars Distalis, Hyperplasia 7 (14%) 7 (15%) 9 (18%) 8 (16%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 34 (68%) 37 (74%) 34 (68%) 41 (82%)
Follicular Cell, Hyperplasia 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 2 (4%)
Preputial Gland (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Inflammation, Chronic Active 5 (10%) 3 (6%) 3 (6%) 9 (18%)
Prostate (50) (50) (50) (50)
Inflammation, Chronic Active 7 (14%) 9 (18%) 2 (4%) 8 (16%)
Inflammation, Suppurative 4 (8%) 2 (4%) 3 (6%) 6 (12%)
Seminal Vesicle (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 4 (8%) 7 (14%) 5 (10%) 6 (12%)
Artery, Inflammation 4 (8%) 3 (6%)
Interstitial Cell, Hyperplasia 17 (34%) 17 (34%) 12 (24%) 16 (32%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Congestion 1 (2%)
Myelofibrosis 2 (4%) 1 (2%) 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Lymph Node (17) (13) (17) (13)
Pancreatic, Inflammation, Granulomatous 1 (6%)
Renal, Hemorrhage 1 (8%) 2 (12%) 2 (15%)
Renal, Infiltration Cellular, Plasma Cell 1 (6%) 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Inflammation, Granulomatous 1 (6%) 1 (8%)
Renal, Pigmentation 2 (12%) 1 (8%) 2 (12%) 1 (8%)
Lymph Node, Mandibular (48) (48) (48) (49)
Hemorrhage 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 3 (6%) 5 (10%)
Inflammation, Granulomatous 1 (2%)
Lymph Node, Mesenteric (50) (50) (48) (50)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Lymph Node, Mediastinal (50) (45) (50) (47)
Hemorrhage 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spleen (50) (50) (50) (50)
Fibrosis 14 (28%) 20 (40%) 26 (52%) 19 (38%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Necrosis 1 (2%) 1 (2%)
Thymus (45) (45) (48) (46)
Artery, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (28) (27) (31) (28)
Galactocele 2 (7%) 2 (6%) 3 (11%)
Hyperplasia 1 (4%)
Hyperplasia, Atypical 1 (4%) 1 (4%)
Duct, Inflammation, Chronic 1 (4%)
Skin (50) (49) (50) (50)
Cyst 2 (4%) 1 (2%)
Hyperkeratosis 3 (6%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Prepuce, Inflammation, Acute 2 (4%) 1 (2%)
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 3 (6%) 4 (8%) 2 (4%)
Hyperostosis 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Degeneration 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hydrocephalus 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Artery, Inflammation 1 (2%)
Peripheral Nerve (1)
Radicular Neuropathy 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Metaplasia, Squamous 1 (2%) 1 (2%)
Lung (50) (50) (50) (50)
Congestion 1 (2%) 1 (2%) 1 (2%)
Congestion, Chronic 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 8 (16%) 10 (20%) 9 (18%)
Artery, Mediastinum, Inflammation 2 (4%)
Nose (50) (50) (50) (50)
Foreign Body 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 4 (8%) 1 (2%) 3 (6%) 2 (4%)
Inflammation, Suppurative 10 (20%) 3 (6%) 3 (6%) 5 (10%)
Thrombosis 6 (12%) 3 (6%) 5 (10%) 2 (4%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 3 (6%)
Olfactory Epithelium, Foreign Body 1 (2%)
Olfactory Epithelium, Inflammation,
Suppurative 1 (2%)
Trachea (50) (50) (50) (50)
Mineralization 1 (2%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (1) (1)
Cataract 1 (100%)
Degeneration 2 (100%) 1 (100%) 1 (100%)
Retina, Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 2 (4%) 1 (2%)
Mineralization 1 (2%) 2 (4%)
Nephropathy 50 (100%) 50 (100%) 50 (100%) 50 (100%)
Artery, Inflammation 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Hyperplasia 3 (6%) 2 (4%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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